ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.26083435
2	nucleobase catabolic process (GO:0046113)	4.89538372
3	neuron cell-cell adhesion (GO:0007158)	4.70497405
4	presynaptic membrane assembly (GO:0097105)	4.04434730
5	establishment of mitochondrion localization (GO:0051654)	3.82652915
6	positive regulation of mitochondrial fission (GO:0090141)	3.80937495
7	sequestering of actin monomers (GO:0042989)	3.78632893
8	presynaptic membrane organization (GO:0097090)	3.76051561
9	vocalization behavior (GO:0071625)	3.75357257
10	gamma-aminobutyric acid transport (GO:0015812)	3.75164144
11	DNA double-strand break processing (GO:0000729)	3.68678811
12	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.61195493
13	nonmotile primary cilium assembly (GO:0035058)	3.56715186
14	postsynaptic membrane organization (GO:0001941)	3.53612650
15	neural tube formation (GO:0001841)	3.47396386
16	protein localization to cilium (GO:0061512)	3.43378793
17	regulation of synaptic vesicle exocytosis (GO:2000300)	3.33882893
18	ubiquinone metabolic process (GO:0006743)	3.33265496
19	DNA damage response, detection of DNA damage (GO:0042769)	3.29716008
20	axonal fasciculation (GO:0007413)	3.27910256
21	hippocampus development (GO:0021766)	3.25999528
22	intraciliary transport (GO:0042073)	3.25845641
23	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.25555870
24	protein localization to synapse (GO:0035418)	3.25403046
25	synapse assembly (GO:0007416)	3.22377811
26	neuron recognition (GO:0008038)	3.19110395
27	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.18628507
28	synaptic vesicle maturation (GO:0016188)	3.16528221
29	behavioral response to nicotine (GO:0035095)	3.10048151
30	cerebral cortex radially oriented cell migration (GO:0021799)	3.07656778
31	glycosphingolipid biosynthetic process (GO:0006688)	3.04813374
32	cullin deneddylation (GO:0010388)	3.03469968
33	limb bud formation (GO:0060174)	3.03247602
34	forebrain neuron differentiation (GO:0021879)	3.01940905
35	ribonucleoprotein complex disassembly (GO:0032988)	2.96647995
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.95782080
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.95782080
38	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.94315728
39	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.94106847
40	ubiquinone biosynthetic process (GO:0006744)	2.93388739
41	auditory behavior (GO:0031223)	2.92279880
42	protein deneddylation (GO:0000338)	2.91248275
43	regulation of synaptic vesicle transport (GO:1902803)	2.90946484
44	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.89902501
45	protein-cofactor linkage (GO:0018065)	2.87924226
46	neurotransmitter-gated ion channel clustering (GO:0072578)	2.86078842
47	regulation of development, heterochronic (GO:0040034)	2.84043672
48	proteasome assembly (GO:0043248)	2.83823524
49	glutamate receptor signaling pathway (GO:0007215)	2.83629790
50	transmission of nerve impulse (GO:0019226)	2.81519310
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.81064391
52	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.77137186
53	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.76818442
54	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.76220544
55	histone H2A acetylation (GO:0043968)	2.73826718
56	retinal ganglion cell axon guidance (GO:0031290)	2.73022317
57	organelle disassembly (GO:1903008)	2.71750625
58	cell migration in hindbrain (GO:0021535)	2.71591114
59	neurofilament cytoskeleton organization (GO:0060052)	2.70805814
60	regulation of cilium movement (GO:0003352)	2.69538615
61	synaptic transmission, glutamatergic (GO:0035249)	2.69215551
62	neurotransmitter secretion (GO:0007269)	2.68643082
63	olfactory bulb development (GO:0021772)	2.68570919
64	synaptic vesicle exocytosis (GO:0016079)	2.68548035
65	negative regulation of DNA recombination (GO:0045910)	2.68459487
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.65389130
67	response to pheromone (GO:0019236)	2.64638506
68	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.63395089
69	chaperone-mediated protein transport (GO:0072321)	2.62041824
70	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.59654877
71	anterograde axon cargo transport (GO:0008089)	2.58567731
72	cytoskeleton-dependent intracellular transport (GO:0030705)	2.57700208
73	peptidyl-cysteine modification (GO:0018198)	2.56268610
74	positive regulation of synapse assembly (GO:0051965)	2.55028193
75	protein complex biogenesis (GO:0070271)	2.54835958
76	startle response (GO:0001964)	2.54629010
77	regulation of synapse structural plasticity (GO:0051823)	2.54185802
78	neuronal action potential propagation (GO:0019227)	2.53281375
79	establishment of melanosome localization (GO:0032401)	2.50246398
80	microtubule-based transport (GO:0010970)	2.49943343
81	mitochondrion transport along microtubule (GO:0047497)	2.48500403
82	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.48500403
83	neuron-neuron synaptic transmission (GO:0007270)	2.48291866
84	central nervous system projection neuron axonogenesis (GO:0021952)	2.47544479
85	short-term memory (GO:0007614)	2.47375301
86	protein neddylation (GO:0045116)	2.47044565
87	regulation of oligodendrocyte differentiation (GO:0048713)	2.46998249
88	glial cell proliferation (GO:0014009)	2.46269234
89	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.46192231
90	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.46192231
91	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.45269394
92	mechanosensory behavior (GO:0007638)	2.45138236
93	de novo posttranslational protein folding (GO:0051084)	2.44481144
94	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.42654551
95	L-methionine salvage (GO:0071267)	2.41996218
96	L-methionine biosynthetic process (GO:0071265)	2.41996218
97	amino acid salvage (GO:0043102)	2.41996218
98	somite development (GO:0061053)	2.41617272
99	mRNA splice site selection (GO:0006376)	2.40227600
100	dendrite morphogenesis (GO:0048813)	2.40056303

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.29785598
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.12536236
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98951545
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.91958214
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.82177083
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.76692237
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76150370
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.71877095
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.56007525
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.55842905
11	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50143589
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48646750
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.41047427
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40725306
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.38539525
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35485193
17	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32924224
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13255698
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10901053
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04371151
21	FUS_26573619_Chip-Seq_HEK293_Human	2.02487263
22	EWS_26573619_Chip-Seq_HEK293_Human	2.01911663
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.00763843
24	VDR_22108803_ChIP-Seq_LS180_Human	1.94587778
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.88821180
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84277440
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79831527
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77350505
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74423041
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69185041
31	P300_19829295_ChIP-Seq_ESCs_Human	1.66929044
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66660864
33	* VDR_23849224_ChIP-Seq_CD4+_Human	1.62369363
34	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59739847
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54476644
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53155443
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50018194
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49613930
39	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.48654123
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47181547
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.46799429
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46778331
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44516275
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44253241
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42630577
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41731374
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40504062
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36828117
49	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.36354122
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32577100
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.30869354
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30854381
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29063074
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.29063074
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.28733909
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27735523
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.25835917
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24661707
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22391023
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21399901
61	* GABP_19822575_ChIP-Seq_HepG2_Human	1.21187304
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21130460
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19884258
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13903199
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13506233
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13354532
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13147196
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11010891
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10802735
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09787848
71	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09384320
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09374072
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.08900534
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.08855742
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08436255
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08332196
77	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06782080
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06702880
79	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06602852
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06081507
81	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05453734
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.04937619
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03314587
84	AR_25329375_ChIP-Seq_VCAP_Human	1.03156604
85	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00847431
86	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96331735
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95755801
88	SOX9_26525672_Chip-Seq_HEART_Mouse	0.94223584
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94099305
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94087455
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94036682
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93646173
93	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.91194473
94	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.90519134
95	JUN_21703547_ChIP-Seq_K562_Human	0.89277335
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89271151
97	STAT3_23295773_ChIP-Seq_U87_Human	0.88404610
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88251497
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88249753
100	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88023313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.68158384
2	MP0001529_abnormal_vocalization	3.20493377
3	MP0003122_maternal_imprinting	3.17564841
4	MP0004859_abnormal_synaptic_plasticity	2.89284596
5	MP0001984_abnormal_olfaction	2.48544769
6	MP0001188_hyperpigmentation	2.46938147
7	MP0004270_analgesia	2.46454008
8	MP0003121_genomic_imprinting	2.42918287
9	MP0002736_abnormal_nociception_after	2.41263235
10	MP0005499_abnormal_olfactory_system	2.34449736
11	MP0005394_taste/olfaction_phenotype	2.34449736
12	MP0000778_abnormal_nervous_system	2.32172694
13	MP0008789_abnormal_olfactory_epithelium	2.29354998
14	MP0002102_abnormal_ear_morphology	2.29117355
15	MP0003787_abnormal_imprinting	2.18873443
16	MP0001968_abnormal_touch/_nociception	2.17551895
17	MP0008877_abnormal_DNA_methylation	2.16198094
18	MP0003635_abnormal_synaptic_transmissio	2.13271444
19	MP0005645_abnormal_hypothalamus_physiol	2.09725816
20	MP0005423_abnormal_somatic_nervous	2.07318900
21	MP0002822_catalepsy	2.07180772
22	MP0006276_abnormal_autonomic_nervous	2.04409794
23	MP0002272_abnormal_nervous_system	1.91658550
24	MP0002063_abnormal_learning/memory/cond	1.90320788
25	MP0009745_abnormal_behavioral_response	1.89060078
26	MP0009046_muscle_twitch	1.87945431
27	MP0008995_early_reproductive_senescence	1.84270189
28	MP0002638_abnormal_pupillary_reflex	1.73403607
29	MP0005646_abnormal_pituitary_gland	1.71905752
30	MP0002734_abnormal_mechanical_nocicepti	1.67904790
31	MP0002572_abnormal_emotion/affect_behav	1.63683545
32	MP0002735_abnormal_chemical_nociception	1.63221274
33	MP0001486_abnormal_startle_reflex	1.59133659
34	MP0002064_seizures	1.55857781
35	MP0004142_abnormal_muscle_tone	1.55442720
36	MP0004885_abnormal_endolymph	1.55415603
37	MP0004133_heterotaxia	1.52911171
38	MP0000955_abnormal_spinal_cord	1.51052749
39	MP0003011_delayed_dark_adaptation	1.50325491
40	MP0006072_abnormal_retinal_apoptosis	1.49232553
41	MP0002184_abnormal_innervation	1.49121557
42	MP0000631_abnormal_neuroendocrine_gland	1.48438281
43	MP0000049_abnormal_middle_ear	1.43722971
44	MP0004811_abnormal_neuron_physiology	1.43336984
45	MP0002234_abnormal_pharynx_morphology	1.43034380
46	MP0006292_abnormal_olfactory_placode	1.42093217
47	MP0002557_abnormal_social/conspecific_i	1.42026566
48	MP0005253_abnormal_eye_physiology	1.40587649
49	MP0002653_abnormal_ependyma_morphology	1.36446725
50	MP0002067_abnormal_sensory_capabilities	1.31592931
51	MP0002751_abnormal_autonomic_nervous	1.31148445
52	MP0002882_abnormal_neuron_morphology	1.29280950
53	MP0005386_behavior/neurological_phenoty	1.29179982
54	MP0004924_abnormal_behavior	1.29179982
55	MP0003221_abnormal_cardiomyocyte_apopto	1.27255411
56	MP0001905_abnormal_dopamine_level	1.21939684
57	MP0003938_abnormal_ear_development	1.21767318
58	MP0008058_abnormal_DNA_repair	1.19723902
59	MP0003567_abnormal_fetal_cardiomyocyte	1.19595311
60	MP0005551_abnormal_eye_electrophysiolog	1.18190887
61	MP0004147_increased_porphyrin_level	1.15859289
62	MP0001970_abnormal_pain_threshold	1.12165959
63	MP0002752_abnormal_somatic_nervous	1.11724845
64	MP0003119_abnormal_digestive_system	1.09008594
65	MP0001502_abnormal_circadian_rhythm	1.08559676
66	MP0002152_abnormal_brain_morphology	1.08274862
67	MP0000566_synostosis	1.08052189
68	MP0001177_atelectasis	1.07643096
69	MP0002733_abnormal_thermal_nociception	1.02762168
70	MP0004742_abnormal_vestibular_system	1.02481479
71	MP0002233_abnormal_nose_morphology	1.01885410
72	MP0005187_abnormal_penis_morphology	1.01270633
73	MP0002066_abnormal_motor_capabilities/c	0.99351638
74	MP0003861_abnormal_nervous_system	0.96307973
75	MP0006035_abnormal_mitochondrial_morpho	0.96133262
76	MP0001986_abnormal_taste_sensitivity	0.95798912
77	MP0002909_abnormal_adrenal_gland	0.95447054
78	MP0003937_abnormal_limbs/digits/tail_de	0.92565568
79	MP0001293_anophthalmia	0.90218577
80	MP0000026_abnormal_inner_ear	0.89888293
81	MP0003890_abnormal_embryonic-extraembry	0.88803845
82	MP0002069_abnormal_eating/drinking_beha	0.87957521
83	MP0005084_abnormal_gallbladder_morpholo	0.86628093
84	MP0005391_vision/eye_phenotype	0.84509855
85	MP0000647_abnormal_sebaceous_gland	0.83289092
86	MP0001299_abnormal_eye_distance/	0.82431918
87	MP0002229_neurodegeneration	0.79039145
88	MP0001963_abnormal_hearing_physiology	0.76719681
89	MP0003755_abnormal_palate_morphology	0.76005310
90	MP0005248_abnormal_Harderian_gland	0.73616626
91	MP0003137_abnormal_impulse_conducting	0.69584506
92	MP0005195_abnormal_posterior_eye	0.69403109
93	MP0008569_lethality_at_weaning	0.68187039
94	MP0001270_distended_abdomen	0.66876623
95	MP0003698_abnormal_male_reproductive	0.65593816
96	MP0002210_abnormal_sex_determination	0.63368708
97	MP0010386_abnormal_urinary_bladder	0.62599030
98	MP0003786_premature_aging	0.62422813
99	MP0001764_abnormal_homeostasis	0.61053605
100	MP0002081_perinatal_lethality	0.60648511

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gait imbalance (HP:0002141)	3.92561889
2	Medial flaring of the eyebrow (HP:0010747)	3.64039046
3	Congenital primary aphakia (HP:0007707)	3.60598148
4	Nephrogenic diabetes insipidus (HP:0009806)	3.55504397
5	Abnormality of the labia minora (HP:0012880)	3.23506697
6	Amyotrophic lateral sclerosis (HP:0007354)	3.21948220
7	Cortical dysplasia (HP:0002539)	3.18052684
8	True hermaphroditism (HP:0010459)	3.08805109
9	Polyphagia (HP:0002591)	3.04519746
10	Myokymia (HP:0002411)	3.04406007
11	Genital tract atresia (HP:0001827)	2.93828331
12	Vaginal atresia (HP:0000148)	2.92379568
13	Drooling (HP:0002307)	2.90623264
14	Limb dystonia (HP:0002451)	2.90437902
15	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.82208039
16	Hyperglycinemia (HP:0002154)	2.72127465
17	Excessive salivation (HP:0003781)	2.67911084
18	Focal motor seizures (HP:0011153)	2.65836081
19	Pancreatic cysts (HP:0001737)	2.65135347
20	Lissencephaly (HP:0001339)	2.64651534
21	Pancreatic fibrosis (HP:0100732)	2.57728975
22	Specific learning disability (HP:0001328)	2.57282041
23	Poor suck (HP:0002033)	2.55987024
24	Thyroid-stimulating hormone excess (HP:0002925)	2.46223986
25	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.44013473
26	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.44013473
27	Methylmalonic acidemia (HP:0002912)	2.42939688
28	Acute necrotizing encephalopathy (HP:0006965)	2.42712866
29	Abnormality of the corticospinal tract (HP:0002492)	2.42507043
30	Abnormality of the lower motor neuron (HP:0002366)	2.40396618
31	Poor coordination (HP:0002370)	2.39000583
32	Urinary urgency (HP:0000012)	2.35753532
33	Split foot (HP:0001839)	2.31496757
34	Shoulder girdle muscle weakness (HP:0003547)	2.30293246
35	Broad-based gait (HP:0002136)	2.29238485
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.23664761
37	Intestinal atresia (HP:0011100)	2.22970621
38	Focal seizures (HP:0007359)	2.22559812
39	Pachygyria (HP:0001302)	2.21214610
40	Decreased testicular size (HP:0008734)	2.17304374
41	Atonic seizures (HP:0010819)	2.16860106
42	Epileptic encephalopathy (HP:0200134)	2.15823754
43	Increased hepatocellular lipid droplets (HP:0006565)	2.14850271
44	Hyperventilation (HP:0002883)	2.14569955
45	Dyskinesia (HP:0100660)	2.13773330
46	Tubulointerstitial nephritis (HP:0001970)	2.13753097
47	Nephronophthisis (HP:0000090)	2.12660095
48	Retinal dysplasia (HP:0007973)	2.12495699
49	Progressive macrocephaly (HP:0004481)	2.11015214
50	Acute encephalopathy (HP:0006846)	2.09777456
51	Mitochondrial inheritance (HP:0001427)	2.08415573
52	Abnormality of midbrain morphology (HP:0002418)	2.08067735
53	Molar tooth sign on MRI (HP:0002419)	2.08067735
54	Abnormality of the hip-girdle musculature (HP:0001445)	2.07619685
55	Abnormality of the musculature of the pelvis (HP:0001469)	2.07619685
56	Postaxial hand polydactyly (HP:0001162)	2.05504191
57	Failure to thrive in infancy (HP:0001531)	2.05438135
58	Broad foot (HP:0001769)	2.04216775
59	3-Methylglutaconic aciduria (HP:0003535)	2.02404468
60	Cerebral hypomyelination (HP:0006808)	2.01487373
61	Increased CSF lactate (HP:0002490)	2.01322834
62	Hypoplasia of the brainstem (HP:0002365)	2.00113323
63	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.00113323
64	Impaired vibration sensation in the lower limbs (HP:0002166)	1.99645223
65	Progressive inability to walk (HP:0002505)	1.99382247
66	Absent speech (HP:0001344)	1.99349115
67	Febrile seizures (HP:0002373)	1.99120931
68	Abnormality of the anterior horn cell (HP:0006802)	1.97369998
69	Degeneration of anterior horn cells (HP:0002398)	1.97369998
70	Muscular hypotonia of the trunk (HP:0008936)	1.96659497
71	Volvulus (HP:0002580)	1.93324763
72	CNS hypomyelination (HP:0003429)	1.92479406
73	Hypsarrhythmia (HP:0002521)	1.90696534
74	Spastic tetraplegia (HP:0002510)	1.89557952
75	Spastic gait (HP:0002064)	1.89540774
76	Esotropia (HP:0000565)	1.89338014
77	Neonatal respiratory distress (HP:0002643)	1.86632307
78	Morphological abnormality of the pyramidal tract (HP:0002062)	1.86412104
79	Lipid accumulation in hepatocytes (HP:0006561)	1.85895250
80	Occipital encephalocele (HP:0002085)	1.85118264
81	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82370277
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82370277
83	EEG with generalized epileptiform discharges (HP:0011198)	1.81178257
84	Hepatocellular necrosis (HP:0001404)	1.79938533
85	Abnormal eating behavior (HP:0100738)	1.79919667
86	Ankle clonus (HP:0011448)	1.79241613
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79192549
88	Epileptiform EEG discharges (HP:0011182)	1.78727223
89	Short tibia (HP:0005736)	1.78661607
90	Postnatal microcephaly (HP:0005484)	1.78415650
91	Sclerocornea (HP:0000647)	1.77372486
92	Postaxial foot polydactyly (HP:0001830)	1.76976774
93	Abnormality of alanine metabolism (HP:0010916)	1.75771891
94	Hyperalaninemia (HP:0003348)	1.75771891
95	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75771891
96	Inability to walk (HP:0002540)	1.74725525
97	Renal cortical cysts (HP:0000803)	1.74317531
98	Anencephaly (HP:0002323)	1.74232766
99	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73747358
100	Methylmalonic aciduria (HP:0012120)	1.71510759

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	4.14577905
2	MARK1	4.08910129
3	CASK	3.38633042
4	MAP3K4	3.16017423
5	TRIM28	3.13815134
6	MAP2K7	2.84667905
7	MAP4K2	2.70598876
8	SRPK1	2.68773309
9	WNK3	2.66193688
10	ERBB3	2.52099914
11	MAPK13	2.30643366
12	EPHA4	2.22347496
13	DYRK2	2.18277549
14	CSNK1G2	1.82634423
15	MINK1	1.74684875
16	CSNK1G3	1.67852258
17	PINK1	1.67786707
18	TSSK6	1.57912790
19	SIK3	1.55446388
20	PLK2	1.52727910
21	TNIK	1.51010034
22	NTRK2	1.50080713
23	UHMK1	1.45780463
24	CSNK1A1L	1.43755640
25	CSNK1G1	1.42319011
26	BCKDK	1.40805998
27	EPHA3	1.38574447
28	STK16	1.38419762
29	SIK2	1.38185842
30	DYRK3	1.35282979
31	RPS6KA4	1.24295653
32	PRKCG	1.21011086
33	CDK19	1.10592799
34	LIMK1	1.06275777
35	MAP2K4	1.04810387
36	BMPR1B	1.04180768
37	PAK3	1.01839611
38	MKNK1	0.99085120
39	EIF2AK1	0.97450282
40	KSR1	0.96516910
41	NTRK3	0.95484402
42	NEK1	0.90752894
43	PAK6	0.89555287
44	MKNK2	0.88337902
45	DYRK1B	0.85701783
46	DYRK1A	0.84213405
47	VRK1	0.83637778
48	PLK4	0.82140563
49	CDK5	0.81841661
50	PLK3	0.80995423
51	PRKCE	0.80217917
52	CDK14	0.74515834
53	EIF2AK3	0.72319846
54	CCNB1	0.71910012
55	TESK1	0.68328376
56	CAMK2A	0.67577038
57	CAMK2B	0.64391136
58	CDK18	0.63033943
59	SGK494	0.62856016
60	SGK223	0.62856016
61	ADRBK2	0.61924351
62	CAMKK2	0.61830988
63	PKN1	0.59006562
64	GRK1	0.57327198
65	CSNK1A1	0.55199346
66	MAP3K12	0.55195862
67	MAP3K5	0.55038595
68	CSNK1E	0.52745121
69	TESK2	0.51062679
70	CDK15	0.50610766
71	RPS6KA5	0.50132675
72	STK38L	0.50073553
73	PHKG2	0.48480375
74	PHKG1	0.48480375
75	WNK4	0.47850552
76	PLK1	0.47191399
77	CDK11A	0.47118924
78	PRKCZ	0.46798329
79	NUAK1	0.46269188
80	STK39	0.46033143
81	CSNK1D	0.44629857
82	DAPK2	0.41837834
83	INSRR	0.40526894
84	ZAK	0.39179376
85	SGK2	0.37847442
86	PRKD3	0.37712034
87	PRKACB	0.37570330
88	OXSR1	0.36921536
89	PRKACA	0.36111322
90	NME1	0.35865758
91	BRD4	0.34157958
92	TAOK3	0.32958980
93	GRK7	0.32059979
94	CSNK2A1	0.30563069
95	ATM	0.30390217
96	CAMK2G	0.29447975
97	PNCK	0.29271642
98	EPHB2	0.28978635
99	CAMKK1	0.28437842
100	AURKA	0.28282617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.56823041
2	Protein export_Homo sapiens_hsa03060	3.44487883
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.73193681
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.72164341
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.66771652
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.45314503
7	Parkinsons disease_Homo sapiens_hsa05012	2.30482457
8	GABAergic synapse_Homo sapiens_hsa04727	2.22691734
9	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.09906651
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01058561
11	Collecting duct acid secretion_Homo sapiens_hsa04966	1.93111090
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.92209477
13	Butanoate metabolism_Homo sapiens_hsa00650	1.90621326
14	Proteasome_Homo sapiens_hsa03050	1.90092782
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84162850
16	Spliceosome_Homo sapiens_hsa03040	1.82904121
17	Phototransduction_Homo sapiens_hsa04744	1.77770238
18	RNA polymerase_Homo sapiens_hsa03020	1.77260346
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.73149045
20	Basal transcription factors_Homo sapiens_hsa03022	1.61070732
21	Morphine addiction_Homo sapiens_hsa05032	1.57711306
22	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.55052744
23	Huntingtons disease_Homo sapiens_hsa05016	1.54834644
24	Propanoate metabolism_Homo sapiens_hsa00640	1.52896400
25	Dopaminergic synapse_Homo sapiens_hsa04728	1.52378573
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.46433607
27	Alzheimers disease_Homo sapiens_hsa05010	1.44491956
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39391021
29	Circadian entrainment_Homo sapiens_hsa04713	1.36723669
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.33667988
31	Cocaine addiction_Homo sapiens_hsa05030	1.30850460
32	Amphetamine addiction_Homo sapiens_hsa05031	1.29603188
33	RNA degradation_Homo sapiens_hsa03018	1.26974254
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.26647585
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.23860764
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.21253547
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.18788341
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.18019676
39	Taste transduction_Homo sapiens_hsa04742	1.15129726
40	RNA transport_Homo sapiens_hsa03013	1.14561397
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12510971
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12112936
43	Oocyte meiosis_Homo sapiens_hsa04114	1.12082766
44	Vibrio cholerae infection_Homo sapiens_hsa05110	1.11188516
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11043742
46	Fatty acid elongation_Homo sapiens_hsa00062	1.06860608
47	Regulation of autophagy_Homo sapiens_hsa04140	1.03366398
48	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02222038
49	Axon guidance_Homo sapiens_hsa04360	1.01913371
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.01886355
51	Peroxisome_Homo sapiens_hsa04146	1.00081945
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98829436
53	Base excision repair_Homo sapiens_hsa03410	0.98109094
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97756283
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.97442146
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87732515
57	Mismatch repair_Homo sapiens_hsa03430	0.87069307
58	Circadian rhythm_Homo sapiens_hsa04710	0.83683572
59	Serotonergic synapse_Homo sapiens_hsa04726	0.81172566
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76949030
61	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.76632928
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76278083
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75564099
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.71920880
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68333798
66	Cholinergic synapse_Homo sapiens_hsa04725	0.67976184
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.63467536
68	Olfactory transduction_Homo sapiens_hsa04740	0.61776233
69	Alcoholism_Homo sapiens_hsa05034	0.61176089
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.61043574
71	Purine metabolism_Homo sapiens_hsa00230	0.59122740
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58940681
73	Long-term depression_Homo sapiens_hsa04730	0.58844170
74	Folate biosynthesis_Homo sapiens_hsa00790	0.58827228
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.58579028
76	Metabolic pathways_Homo sapiens_hsa01100	0.55617390
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55454805
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.51843326
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50752096
80	Insulin secretion_Homo sapiens_hsa04911	0.47766977
81	Gap junction_Homo sapiens_hsa04540	0.44502981
82	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.44373430
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.42924749
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39026425
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.38702661
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38539234
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32311479
88	Carbon metabolism_Homo sapiens_hsa01200	0.31435562
89	Cell cycle_Homo sapiens_hsa04110	0.30656113
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27321539
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27018938
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.26634284
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.26206146
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.25565904
95	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25075764
96	Long-term potentiation_Homo sapiens_hsa04720	0.24946644
97	Ras signaling pathway_Homo sapiens_hsa04014	0.23316144
98	Phenylalanine metabolism_Homo sapiens_hsa00360	0.20666620
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.20356394
100	Homologous recombination_Homo sapiens_hsa03440	0.17362420

MRFAP1L1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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