

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuronal action potential (GO:0019228) | 9.09885683 |
| 2 | urinary tract smooth muscle contraction (GO:0014848) | 8.94641572 |
| 3 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 8.92372780 |
| 4 | negative regulation of complement activation (GO:0045916) | 8.91587410 |
| 5 | behavioral response to pain (GO:0048266) | 8.61303734 |
| 6 | negative regulation of dendrite morphogenesis (GO:0050774) | 8.12600194 |
| 7 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 7.92400617 |
| 8 | adenosine metabolic process (GO:0046085) | 7.53465256 |
| 9 | negative regulation of protein activation cascade (GO:2000258) | 7.46565884 |
| 10 | peristalsis (GO:0030432) | 6.85373785 |
| 11 | response to pain (GO:0048265) | 6.62929184 |
| 12 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 6.57461446 |
| 13 | negative regulation of humoral immune response (GO:0002921) | 6.17504746 |
| 14 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 5.88900433 |
| 15 | positive regulation of muscle hypertrophy (GO:0014742) | 5.88900433 |
| 16 | membrane depolarization during action potential (GO:0086010) | 5.73227724 |
| 17 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 5.62361270 |
| 18 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 5.52742933 |
| 19 | negative regulation of dendrite development (GO:2000171) | 5.25319535 |
| 20 | response to ATP (GO:0033198) | 5.23625943 |
| 21 | positive regulation of amino acid transport (GO:0051957) | 5.10939384 |
| 22 | regulation of platelet aggregation (GO:0090330) | 5.01837070 |
| 23 | enteric nervous system development (GO:0048484) | 5.00924583 |
| 24 | peripheral nervous system neuron development (GO:0048935) | 4.80431335 |
| 25 | neurofilament cytoskeleton organization (GO:0060052) | 4.76583674 |
| 26 | regulation of collateral sprouting (GO:0048670) | 4.64321180 |
| 27 | proline transport (GO:0015824) | 4.52662316 |
| 28 | cellular response to prostaglandin stimulus (GO:0071379) | 4.49185127 |
| 29 | neuromuscular synaptic transmission (GO:0007274) | 4.48301128 |
| 30 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 4.37951124 |
| 31 | cell communication involved in cardiac conduction (GO:0086065) | 4.37576844 |
| 32 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 4.33776710 |
| 33 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 4.33776710 |
| 34 | action potential (GO:0001508) | 4.31173389 |
| 35 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 4.17190407 |
| 36 | membrane repolarization (GO:0086009) | 4.13982504 |
| 37 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.12725323 |
| 38 | detection of temperature stimulus (GO:0016048) | 4.11697695 |
| 39 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 4.11615659 |
| 40 | regulation of sensory perception of pain (GO:0051930) | 4.03337136 |
| 41 | regulation of sensory perception (GO:0051931) | 4.03337136 |
| 42 | potassium ion export (GO:0071435) | 4.03223678 |
| 43 | regulation of homotypic cell-cell adhesion (GO:0034110) | 3.80348084 |
| 44 | acrosome reaction (GO:0007340) | 3.74002119 |
| 45 | regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664) | 3.70152430 |
| 46 | detection of mechanical stimulus involved in sensory perception (GO:0050974) | 3.67992793 |
| 47 | phasic smooth muscle contraction (GO:0014821) | 3.66582352 |
| 48 | cellular potassium ion homeostasis (GO:0030007) | 3.64100902 |
| 49 | alanine transport (GO:0032328) | 3.62559165 |
| 50 | glycosphingolipid biosynthetic process (GO:0006688) | 3.60658085 |
| 51 | negative regulation of sodium ion transport (GO:0010766) | 3.59263194 |
| 52 | cytokine production involved in immune response (GO:0002367) | 3.57606459 |
| 53 | sodium ion transmembrane transport (GO:0035725) | 3.57003006 |
| 54 | multicellular organismal response to stress (GO:0033555) | 3.52823526 |
| 55 | synaptic vesicle maturation (GO:0016188) | 3.50251606 |
| 56 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.47832894 |
| 57 | establishment of mitochondrion localization (GO:0051654) | 3.46160125 |
| 58 | sensory perception of taste (GO:0050909) | 3.44462136 |
| 59 | regulation of cardiac muscle hypertrophy (GO:0010611) | 3.41412914 |
| 60 | cell migration in hindbrain (GO:0021535) | 3.41316530 |
| 61 | glutamate secretion (GO:0014047) | 3.35766730 |
| 62 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.35640861 |
| 63 | sodium ion export (GO:0071436) | 3.35116142 |
| 64 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.30540040 |
| 65 | regulation of membrane depolarization (GO:0003254) | 3.30090542 |
| 66 | regulation of muscle hypertrophy (GO:0014743) | 3.26500671 |
| 67 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 3.19096790 |
| 68 | dopamine receptor signaling pathway (GO:0007212) | 3.18088276 |
| 69 | negative regulation of microtubule polymerization (GO:0031115) | 3.15472701 |
| 70 | axon cargo transport (GO:0008088) | 3.14538080 |
| 71 | calcium ion-dependent exocytosis (GO:0017156) | 3.09882288 |
| 72 | vesicle transport along microtubule (GO:0047496) | 3.07473856 |
| 73 | membrane depolarization (GO:0051899) | 3.05535023 |
| 74 | sleep (GO:0030431) | 3.04474817 |
| 75 | regulation of cell communication by electrical coupling (GO:0010649) | 2.95629225 |
| 76 | glycine transport (GO:0015816) | 2.91471906 |
| 77 | regulation of amino acid transport (GO:0051955) | 2.90763553 |
| 78 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 2.90349827 |
| 79 | cellular sodium ion homeostasis (GO:0006883) | 2.88509759 |
| 80 | positive regulation of potassium ion transport (GO:0043268) | 2.84910962 |
| 81 | regulation of dopamine secretion (GO:0014059) | 2.83980168 |
| 82 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G- | 2.83238366 |
| 83 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.80097759 |
| 84 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.80002176 |
| 85 | organelle transport along microtubule (GO:0072384) | 2.79796540 |
| 86 | retinal ganglion cell axon guidance (GO:0031290) | 2.79395806 |
| 87 | purinergic receptor signaling pathway (GO:0035587) | 2.77918855 |
| 88 | response to cold (GO:0009409) | 2.76644109 |
| 89 | regulation of potassium ion transmembrane transport (GO:1901379) | 2.76584296 |
| 90 | membrane budding (GO:0006900) | 2.76028830 |
| 91 | positive regulation of calcium ion transport into cytosol (GO:0010524) | 2.75454057 |
| 92 | response to water (GO:0009415) | 2.74020720 |
| 93 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.71858594 |
| 94 | positive regulation of amine transport (GO:0051954) | 2.68510234 |
| 95 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.66682799 |
| 96 | regulation of cardiac muscle contraction (GO:0055117) | 2.63337740 |
| 97 | mitochondrion transport along microtubule (GO:0047497) | 2.62777349 |
| 98 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.62777349 |
| 99 | neuronal action potential propagation (GO:0019227) | 2.61862580 |
| 100 | regulation of sodium ion transmembrane transporter activity (GO:2000649) | 2.61560601 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VDR_22108803_ChIP-Seq_LS180_Human | 3.49345110 |
| 2 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.23668630 |
| 3 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 3.03014634 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.81226406 |
| 5 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.68669494 |
| 6 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.48377726 |
| 7 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.45743380 |
| 8 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.43022824 |
| 9 | EGR1_19032775_ChIP-ChIP_M12_Human | 2.33039511 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.30258850 |
| 11 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.30064429 |
| 12 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.29255340 |
| 13 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.28057938 |
| 14 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.27318591 |
| 15 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.27318591 |
| 16 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.26028515 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.23634540 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.22642036 |
| 19 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.16516335 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.08787368 |
| 21 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.96640546 |
| 22 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.96497176 |
| 23 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.90269498 |
| 24 | GATA1_22025678_ChIP-Seq_K562_Human | 1.86093939 |
| 25 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.74443283 |
| 26 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.70709603 |
| 27 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.69821227 |
| 28 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.67958480 |
| 29 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.63963987 |
| 30 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.59323856 |
| 31 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.55950970 |
| 32 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.51768734 |
| 33 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.51726569 |
| 34 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.50303987 |
| 35 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.49389402 |
| 36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.48894792 |
| 37 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.46302531 |
| 38 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.46191005 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.44211040 |
| 40 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.44167445 |
| 41 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.43703396 |
| 42 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.38836952 |
| 43 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.38494791 |
| 44 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.38375361 |
| 45 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.35212726 |
| 46 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.32815479 |
| 47 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.30398471 |
| 48 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.29193627 |
| 49 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.28485966 |
| 50 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.28283823 |
| 51 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.28031520 |
| 52 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.27305347 |
| 53 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.27148172 |
| 54 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.27049567 |
| 55 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.23468275 |
| 56 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.20619248 |
| 57 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.19901305 |
| 58 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.18816365 |
| 59 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.18479143 |
| 60 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15856318 |
| 61 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.14553559 |
| 62 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.14186989 |
| 63 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.14073731 |
| 64 | P300_19829295_ChIP-Seq_ESCs_Human | 1.12887510 |
| 65 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.12407901 |
| 66 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.11728408 |
| 67 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.10606847 |
| 68 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.09918879 |
| 69 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.07469789 |
| 70 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03951279 |
| 71 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.03564710 |
| 72 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.02616981 |
| 73 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.01961792 |
| 74 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.01813250 |
| 75 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.01813250 |
| 76 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.01563855 |
| 77 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01563855 |
| 78 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01558408 |
| 79 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01369359 |
| 80 | STAT3_23295773_ChIP-Seq_U87_Human | 1.01065145 |
| 81 | AR_19668381_ChIP-Seq_PC3_Human | 1.00814028 |
| 82 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.00669549 |
| 83 | KDM2B_26808549_Chip-Seq_K562_Human | 0.99881258 |
| 84 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.96776507 |
| 85 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.96272146 |
| 86 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.94088104 |
| 87 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.93156714 |
| 88 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.92979274 |
| 89 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92796424 |
| 90 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.91863993 |
| 91 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.91507902 |
| 92 | KDM2B_26808549_Chip-Seq_REH_Human | 0.90972877 |
| 93 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.90014395 |
| 94 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.89008874 |
| 95 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88606248 |
| 96 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.87754189 |
| 97 | CJUN_26792858_Chip-Seq_BT549_Human | 0.87578448 |
| 98 | AR_25329375_ChIP-Seq_VCAP_Human | 0.87394561 |
| 99 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.86037517 |
| 100 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.84887412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002735_abnormal_chemical_nociception | 9.36613512 |
| 2 | * MP0001968_abnormal_touch/_nociception | 8.67110233 |
| 3 | * MP0002736_abnormal_nociception_after | 7.97254983 |
| 4 | MP0001986_abnormal_taste_sensitivity | 5.15604037 |
| 5 | * MP0002733_abnormal_thermal_nociception | 4.39589660 |
| 6 | * MP0001970_abnormal_pain_threshold | 3.66745210 |
| 7 | * MP0002734_abnormal_mechanical_nocicepti | 3.56265985 |
| 8 | MP0004270_analgesia | 3.44990918 |
| 9 | MP0006276_abnormal_autonomic_nervous | 3.08044930 |
| 10 | MP0003656_abnormal_erythrocyte_physiolo | 2.93524733 |
| 11 | MP0004858_abnormal_nervous_system | 2.82752380 |
| 12 | * MP0002272_abnormal_nervous_system | 2.23655678 |
| 13 | MP0004859_abnormal_synaptic_plasticity | 1.86944671 |
| 14 | * MP0002067_abnormal_sensory_capabilities | 1.78701191 |
| 15 | MP0002751_abnormal_autonomic_nervous | 1.58640252 |
| 16 | MP0001270_distended_abdomen | 1.56387357 |
| 17 | MP0003329_amyloid_beta_deposits | 1.51205422 |
| 18 | MP0003635_abnormal_synaptic_transmissio | 1.42676628 |
| 19 | MP0002184_abnormal_innervation | 1.40403141 |
| 20 | MP0005083_abnormal_biliary_tract | 1.32971254 |
| 21 | MP0003806_abnormal_nucleotide_metabolis | 1.29563924 |
| 22 | MP0002837_dystrophic_cardiac_calcinosis | 1.25114026 |
| 23 | MP0004811_abnormal_neuron_physiology | 1.24227138 |
| 24 | MP0000955_abnormal_spinal_cord | 1.11596574 |
| 25 | MP0001348_abnormal_lacrimal_gland | 1.10995348 |
| 26 | MP0010234_abnormal_vibrissa_follicle | 1.09301610 |
| 27 | * MP0010771_integument_phenotype | 1.07643752 |
| 28 | MP0000604_amyloidosis | 1.05478122 |
| 29 | MP0003880_abnormal_central_pattern | 1.03457033 |
| 30 | MP0002064_seizures | 1.01252831 |
| 31 | MP0005423_abnormal_somatic_nervous | 0.92604294 |
| 32 | MP0008260_abnormal_autophagy | 0.91850219 |
| 33 | MP0001299_abnormal_eye_distance/ | 0.91632379 |
| 34 | MP0002063_abnormal_learning/memory/cond | 0.87750275 |
| 35 | MP0008874_decreased_physiological_sensi | 0.86736337 |
| 36 | MP0001984_abnormal_olfaction | 0.82629936 |
| 37 | MP0004130_abnormal_muscle_cell | 0.82205602 |
| 38 | MP0009745_abnormal_behavioral_response | 0.81758021 |
| 39 | MP0003633_abnormal_nervous_system | 0.80314233 |
| 40 | MP0009046_muscle_twitch | 0.78995804 |
| 41 | MP0000579_abnormal_nail_morphology | 0.77296221 |
| 42 | MP0003045_fibrosis | 0.76789037 |
| 43 | MP0000427_abnormal_hair_cycle | 0.76136746 |
| 44 | MP0000749_muscle_degeneration | 0.75900273 |
| 45 | MP0000538_abnormal_urinary_bladder | 0.75227668 |
| 46 | MP0000747_muscle_weakness | 0.73084568 |
| 47 | MP0001727_abnormal_embryo_implantation | 0.72499760 |
| 48 | MP0002909_abnormal_adrenal_gland | 0.71558688 |
| 49 | MP0002572_abnormal_emotion/affect_behav | 0.69808852 |
| 50 | MP0004036_abnormal_muscle_relaxation | 0.69059582 |
| 51 | MP0003634_abnormal_glial_cell | 0.68840963 |
| 52 | * MP0002882_abnormal_neuron_morphology | 0.67207795 |
| 53 | MP0000534_abnormal_ureter_morphology | 0.66030871 |
| 54 | MP0000920_abnormal_myelination | 0.65743617 |
| 55 | MP0008961_abnormal_basal_metabolism | 0.65735434 |
| 56 | MP0003868_abnormal_feces_composition | 0.65037130 |
| 57 | MP0000778_abnormal_nervous_system | 0.65019158 |
| 58 | MP0003172_abnormal_lysosome_physiology | 0.64263643 |
| 59 | MP0000569_abnormal_digit_pigmentation | 0.63443006 |
| 60 | MP0003631_nervous_system_phenotype | 0.60366204 |
| 61 | MP0004185_abnormal_adipocyte_glucose | 0.59831205 |
| 62 | MP0000751_myopathy | 0.59384094 |
| 63 | MP0005464_abnormal_platelet_physiology | 0.58008659 |
| 64 | MP0001661_extended_life_span | 0.57638393 |
| 65 | MP0002066_abnormal_motor_capabilities/c | 0.55749410 |
| 66 | MP0001440_abnormal_grooming_behavior | 0.54334788 |
| 67 | MP0002972_abnormal_cardiac_muscle | 0.49996535 |
| 68 | MP0009697_abnormal_copulation | 0.49293067 |
| 69 | MP0002229_neurodegeneration | 0.47142042 |
| 70 | MP0005165_increased_susceptibility_to | 0.46921726 |
| 71 | MP0004084_abnormal_cardiac_muscle | 0.46138520 |
| 72 | MP0001664_abnormal_digestion | 0.45693619 |
| 73 | MP0009379_abnormal_foot_pigmentation | 0.44838484 |
| 74 | MP0000681_abnormal_thyroid_gland | 0.44204180 |
| 75 | MP0004215_abnormal_myocardial_fiber | 0.43470886 |
| 76 | MP0003137_abnormal_impulse_conducting | 0.42877789 |
| 77 | MP0001905_abnormal_dopamine_level | 0.42720084 |
| 78 | MP0004142_abnormal_muscle_tone | 0.42009656 |
| 79 | MP0010386_abnormal_urinary_bladder | 0.41030360 |
| 80 | MP0004085_abnormal_heartbeat | 0.40492817 |
| 81 | MP0005535_abnormal_body_temperature | 0.39001489 |
| 82 | MP0009780_abnormal_chondrocyte_physiolo | 0.37306270 |
| 83 | MP0005386_behavior/neurological_phenoty | 0.37191642 |
| 84 | MP0004924_abnormal_behavior | 0.37191642 |
| 85 | MP0002282_abnormal_trachea_morphology | 0.34730391 |
| 86 | MP0002557_abnormal_social/conspecific_i | 0.34052642 |
| 87 | MP0002269_muscular_atrophy | 0.33668226 |
| 88 | MP0003183_abnormal_peptide_metabolism | 0.33283282 |
| 89 | MP0002752_abnormal_somatic_nervous | 0.33035394 |
| 90 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.31142606 |
| 91 | MP0000230_abnormal_systemic_arterial | 0.31127080 |
| 92 | MP0003300_gastrointestinal_ulcer | 0.30381415 |
| 93 | MP0008569_lethality_at_weaning | 0.30168311 |
| 94 | MP0003632_abnormal_nervous_system | 0.29837911 |
| 95 | MP0001756_abnormal_urination | 0.29788467 |
| 96 | MP0005595_abnormal_vascular_smooth | 0.27697193 |
| 97 | MP0001943_abnormal_respiration | 0.26960704 |
| 98 | MP0003075_altered_response_to | 0.26311253 |
| 99 | MP0000639_abnormal_adrenal_gland | 0.25406174 |
| 100 | MP0005187_abnormal_penis_morphology | 0.24854253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Dysautonomia (HP:0002459) | 7.05745406 |
| 2 | Ulnar claw (HP:0001178) | 6.85981455 |
| 3 | Abnormality of pain sensation (HP:0010832) | 6.34157876 |
| 4 | Impaired pain sensation (HP:0007328) | 6.34157876 |
| 5 | Termporal pattern (HP:0011008) | 5.58176190 |
| 6 | Insidious onset (HP:0003587) | 5.58176190 |
| 7 | Pheochromocytoma (HP:0002666) | 4.94726629 |
| 8 | Segmental peripheral demyelination/remyelination (HP:0003481) | 4.88482724 |
| 9 | Action tremor (HP:0002345) | 4.62258596 |
| 10 | Neuroendocrine neoplasm (HP:0100634) | 4.49279122 |
| 11 | Myokymia (HP:0002411) | 4.21691927 |
| 12 | Hammertoe (HP:0001765) | 4.15870813 |
| 13 | Distal arthrogryposis (HP:0005684) | 4.04548315 |
| 14 | Abnormal autonomic nervous system physiology (HP:0012332) | 4.04452742 |
| 15 | Ankle clonus (HP:0011448) | 3.71108814 |
| 16 | Onion bulb formation (HP:0003383) | 3.64380950 |
| 17 | Steppage gait (HP:0003376) | 3.54560224 |
| 18 | Focal seizures (HP:0007359) | 3.54299264 |
| 19 | Foot dorsiflexor weakness (HP:0009027) | 3.52298255 |
| 20 | Hypomagnesemia (HP:0002917) | 3.46002944 |
| 21 | Failure to thrive in infancy (HP:0001531) | 3.44637361 |
| 22 | Abnormality of magnesium homeostasis (HP:0004921) | 3.27379844 |
| 23 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 3.23265764 |
| 24 | Thoracolumbar scoliosis (HP:0002944) | 3.22569627 |
| 25 | Distal sensory impairment (HP:0002936) | 3.21004708 |
| 26 | Supranuclear gaze palsy (HP:0000605) | 3.19710257 |
| 27 | Myotonia (HP:0002486) | 3.16662226 |
| 28 | Atonic seizures (HP:0010819) | 3.14290593 |
| 29 | Abnormality of the foot musculature (HP:0001436) | 3.12436575 |
| 30 | Irregular epiphyses (HP:0010582) | 3.04016101 |
| 31 | Hypothermia (HP:0002045) | 2.99399499 |
| 32 | Abnormality of the vocal cords (HP:0008777) | 2.96557515 |
| 33 | Facial shape deformation (HP:0011334) | 2.96464308 |
| 34 | Potter facies (HP:0002009) | 2.96464308 |
| 35 | Submucous cleft hard palate (HP:0000176) | 2.95157506 |
| 36 | Abnormality of the corticospinal tract (HP:0002492) | 2.92281812 |
| 37 | Hypoventilation (HP:0002791) | 2.90925698 |
| 38 | Urinary urgency (HP:0000012) | 2.85182504 |
| 39 | Hyporeflexia of lower limbs (HP:0002600) | 2.74443464 |
| 40 | Hypercortisolism (HP:0001578) | 2.71844665 |
| 41 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.71235807 |
| 42 | Cerebral hemorrhage (HP:0001342) | 2.68673871 |
| 43 | Bradycardia (HP:0001662) | 2.68660240 |
| 44 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.68120183 |
| 45 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.58375656 |
| 46 | Visual hallucinations (HP:0002367) | 2.57334865 |
| 47 | Torticollis (HP:0000473) | 2.55988573 |
| 48 | Hypoplasia of the brainstem (HP:0002365) | 2.35763823 |
| 49 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.35763823 |
| 50 | Ventricular fibrillation (HP:0001663) | 2.35758829 |
| 51 | Peripheral hypomyelination (HP:0007182) | 2.35460352 |
| 52 | Spastic gait (HP:0002064) | 2.34775597 |
| 53 | Abnormality of the ischium (HP:0003174) | 2.33381681 |
| 54 | Axonal loss (HP:0003447) | 2.29559924 |
| 55 | Dialeptic seizures (HP:0011146) | 2.27917511 |
| 56 | Decreased motor nerve conduction velocity (HP:0003431) | 2.27801872 |
| 57 | Areflexia of lower limbs (HP:0002522) | 2.26772366 |
| 58 | Clonus (HP:0002169) | 2.26336118 |
| 59 | Impaired proprioception (HP:0010831) | 2.25377316 |
| 60 | Anosmia (HP:0000458) | 2.23275732 |
| 61 | Febrile seizures (HP:0002373) | 2.18162158 |
| 62 | Chin dimple (HP:0010751) | 2.17158417 |
| 63 | Lower limb muscle weakness (HP:0007340) | 2.16953807 |
| 64 | Craniofacial dystonia (HP:0012179) | 2.16685658 |
| 65 | Thyroid carcinoma (HP:0002890) | 2.16597422 |
| 66 | Overlapping toe (HP:0001845) | 2.11880696 |
| 67 | Absence seizures (HP:0002121) | 2.10190256 |
| 68 | Abnormality of the lower motor neuron (HP:0002366) | 2.08870956 |
| 69 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.08098473 |
| 70 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.07803697 |
| 71 | Postural tremor (HP:0002174) | 2.04973914 |
| 72 | Abnormality of the parathyroid morphology (HP:0011766) | 2.04034825 |
| 73 | Absent phalangeal crease (HP:0006109) | 2.00331038 |
| 74 | Adducted thumb (HP:0001181) | 1.99253793 |
| 75 | Bowel diverticulosis (HP:0005222) | 1.99024886 |
| 76 | Focal dystonia (HP:0004373) | 1.98279759 |
| 77 | Hand muscle atrophy (HP:0009130) | 1.97396749 |
| 78 | Paraplegia (HP:0010550) | 1.95529613 |
| 79 | Neonatal onset (HP:0003623) | 1.93760478 |
| 80 | Generalized tonic-clonic seizures (HP:0002069) | 1.93184301 |
| 81 | Knee flexion contracture (HP:0006380) | 1.92004267 |
| 82 | Autoamputation (HP:0001218) | 1.91304773 |
| 83 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 1.90830071 |
| 84 | Abnormality of femoral epiphyses (HP:0006499) | 1.90830071 |
| 85 | Progressive cerebellar ataxia (HP:0002073) | 1.90186139 |
| 86 | Lower limb asymmetry (HP:0100559) | 1.88168256 |
| 87 | Lumbar hyperlordosis (HP:0002938) | 1.87163552 |
| 88 | Increased CSF protein (HP:0002922) | 1.86561284 |
| 89 | Aqueductal stenosis (HP:0002410) | 1.85655544 |
| 90 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.84596641 |
| 91 | Peripheral demyelination (HP:0011096) | 1.84517810 |
| 92 | Rapidly progressive (HP:0003678) | 1.82310988 |
| 93 | Neuroblastoma (HP:0003006) | 1.81585768 |
| 94 | Primitive neuroectodermal tumor (HP:0030065) | 1.81585768 |
| 95 | Neuroblastic tumors (HP:0004376) | 1.81585768 |
| 96 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.81585768 |
| 97 | Spastic paraplegia (HP:0001258) | 1.81096591 |
| 98 | Papilledema (HP:0001085) | 1.79095078 |
| 99 | Mask-like facies (HP:0000298) | 1.78409237 |
| 100 | Glomerulonephritis (HP:0000099) | 1.78008824 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 6.12101261 |
| 2 | MAP3K9 | 4.54482466 |
| 3 | KSR2 | 3.76949992 |
| 4 | MARK3 | 3.22568453 |
| 5 | GRK5 | 3.18201080 |
| 6 | MAP3K2 | 2.92887738 |
| 7 | LIMK1 | 2.67819527 |
| 8 | MINK1 | 2.64920831 |
| 9 | LMTK2 | 2.54272776 |
| 10 | NTRK1 | 2.47931957 |
| 11 | DAPK2 | 2.44722118 |
| 12 | RET | 2.35824218 |
| 13 | NTRK3 | 2.28142051 |
| 14 | MAP3K12 | 2.07475268 |
| 15 | ARAF | 2.02854356 |
| 16 | EPHA3 | 1.99072428 |
| 17 | PAK6 | 1.85083247 |
| 18 | PRKD3 | 1.82286438 |
| 19 | FRK | 1.55659626 |
| 20 | LATS2 | 1.48975712 |
| 21 | MAP2K4 | 1.44018199 |
| 22 | MAP3K1 | 1.42520519 |
| 23 | PRKG2 | 1.39215826 |
| 24 | MAP2K1 | 1.33247541 |
| 25 | RPS6KA2 | 1.29749220 |
| 26 | YES1 | 1.27347934 |
| 27 | CAMKK2 | 1.18813983 |
| 28 | SGK223 | 1.10810855 |
| 29 | SGK494 | 1.10810855 |
| 30 | FER | 1.09340705 |
| 31 | PHKG2 | 1.06052861 |
| 32 | PHKG1 | 1.06052861 |
| 33 | PDK1 | 1.04627106 |
| 34 | EPHB1 | 1.04616813 |
| 35 | CDK14 | 1.02191797 |
| 36 | FLT3 | 1.01259614 |
| 37 | CDK5 | 0.99687139 |
| 38 | NEK1 | 0.99088040 |
| 39 | MAP3K4 | 0.94779695 |
| 40 | PTK2 | 0.92470674 |
| 41 | FGFR3 | 0.91010993 |
| 42 | UHMK1 | 0.85730753 |
| 43 | FGFR2 | 0.83701138 |
| 44 | MAP2K7 | 0.83063930 |
| 45 | MAP2K2 | 0.80568448 |
| 46 | PRKCZ | 0.78425492 |
| 47 | PINK1 | 0.76922234 |
| 48 | MET | 0.76799423 |
| 49 | PDPK1 | 0.72599151 |
| 50 | SGK2 | 0.71679177 |
| 51 | FGFR4 | 0.71225176 |
| 52 | SCYL2 | 0.69946386 |
| 53 | PAK3 | 0.65653547 |
| 54 | CAMKK1 | 0.64834819 |
| 55 | CSNK1G2 | 0.64286613 |
| 56 | STK39 | 0.61065675 |
| 57 | SIK3 | 0.59588256 |
| 58 | KSR1 | 0.59495130 |
| 59 | DAPK1 | 0.58716127 |
| 60 | MAP3K13 | 0.55113977 |
| 61 | MAP3K11 | 0.54369715 |
| 62 | PDGFRB | 0.51768074 |
| 63 | JAK1 | 0.51469031 |
| 64 | PTK2B | 0.49597811 |
| 65 | CSNK1A1L | 0.48743862 |
| 66 | PRKCH | 0.47984881 |
| 67 | CAMK2A | 0.47851423 |
| 68 | CSNK1G3 | 0.47195885 |
| 69 | RAF1 | 0.47149720 |
| 70 | SGK3 | 0.46779282 |
| 71 | PLK2 | 0.45916535 |
| 72 | MATK | 0.45850582 |
| 73 | WNK1 | 0.45224123 |
| 74 | PDGFRA | 0.45113487 |
| 75 | ADRBK1 | 0.44932919 |
| 76 | HIPK2 | 0.44340689 |
| 77 | CAMK2D | 0.41628008 |
| 78 | DYRK2 | 0.41490996 |
| 79 | MARK1 | 0.41321804 |
| 80 | CDC42BPA | 0.40357008 |
| 81 | PRKCG | 0.39680459 |
| 82 | PRKCE | 0.39538422 |
| 83 | JAK2 | 0.37838545 |
| 84 | PRKCD | 0.37365763 |
| 85 | WNK4 | 0.37004859 |
| 86 | CDK18 | 0.36044090 |
| 87 | MAPK10 | 0.35349723 |
| 88 | TRPM7 | 0.33691597 |
| 89 | MAPK4 | 0.33570956 |
| 90 | FYN | 0.33557097 |
| 91 | LRRK2 | 0.33553474 |
| 92 | ROCK1 | 0.33348199 |
| 93 | PRKCA | 0.32994986 |
| 94 | PDK4 | 0.32851158 |
| 95 | PDK3 | 0.32851158 |
| 96 | SRC | 0.32351653 |
| 97 | AURKA | 0.31037221 |
| 98 | BLK | 0.30630727 |
| 99 | MAPKAPK3 | 0.30380573 |
| 100 | CDK15 | 0.30208045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 4.01077262 |
| 2 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 3.99530714 |
| 3 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 3.54554643 |
| 4 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.89275245 |
| 5 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.63238179 |
| 6 | Insulin secretion_Homo sapiens_hsa04911 | 2.09382296 |
| 7 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.94040292 |
| 8 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.88999305 |
| 9 | Taste transduction_Homo sapiens_hsa04742 | 1.84904348 |
| 10 | Salivary secretion_Homo sapiens_hsa04970 | 1.60919083 |
| 11 | Thyroid cancer_Homo sapiens_hsa05216 | 1.58621656 |
| 12 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.57625224 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 1.57515589 |
| 14 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.55132789 |
| 15 | Olfactory transduction_Homo sapiens_hsa04740 | 1.49884358 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.47040681 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.45803554 |
| 18 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42901557 |
| 19 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.39585454 |
| 20 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.38703738 |
| 21 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.35858421 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.33333479 |
| 23 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.31716490 |
| 24 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.29976769 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.27301184 |
| 26 | Circadian entrainment_Homo sapiens_hsa04713 | 1.25496429 |
| 27 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.25267740 |
| 28 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 1.20774937 |
| 29 | Mineral absorption_Homo sapiens_hsa04978 | 1.20083351 |
| 30 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.15982772 |
| 31 | Glioma_Homo sapiens_hsa05214 | 1.15496407 |
| 32 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.15034737 |
| 33 | Long-term depression_Homo sapiens_hsa04730 | 1.13689878 |
| 34 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.13032568 |
| 35 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.12481877 |
| 36 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.11304105 |
| 37 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.09685794 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.07047134 |
| 39 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.06937800 |
| 40 | Bile secretion_Homo sapiens_hsa04976 | 1.06448814 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.04087890 |
| 42 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.02287034 |
| 43 | Gap junction_Homo sapiens_hsa04540 | 1.02107645 |
| 44 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.99342718 |
| 45 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.97745507 |
| 46 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.95695407 |
| 47 | GABAergic synapse_Homo sapiens_hsa04727 | 0.94809951 |
| 48 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.93662568 |
| 49 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.92462449 |
| 50 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.90853974 |
| 51 | Melanogenesis_Homo sapiens_hsa04916 | 0.90598746 |
| 52 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.90355415 |
| 53 | Salmonella infection_Homo sapiens_hsa05132 | 0.89336419 |
| 54 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.88155279 |
| 55 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.85302911 |
| 56 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.83784007 |
| 57 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.83344391 |
| 58 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.83283149 |
| 59 | Phagosome_Homo sapiens_hsa04145 | 0.81604115 |
| 60 | Melanoma_Homo sapiens_hsa05218 | 0.81426146 |
| 61 | Viral myocarditis_Homo sapiens_hsa05416 | 0.81144849 |
| 62 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.80830981 |
| 63 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.77500872 |
| 64 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.75243981 |
| 65 | Morphine addiction_Homo sapiens_hsa05032 | 0.75124754 |
| 66 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.74572181 |
| 67 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.74571084 |
| 68 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73267941 |
| 69 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.73010772 |
| 70 | Endometrial cancer_Homo sapiens_hsa05213 | 0.71369415 |
| 71 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.70829150 |
| 72 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.69365094 |
| 73 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.68746767 |
| 74 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.66126478 |
| 75 | Amoebiasis_Homo sapiens_hsa05146 | 0.64333733 |
| 76 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.63156189 |
| 77 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.63121958 |
| 78 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.62743742 |
| 79 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.60772535 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.59740551 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58207869 |
| 82 | Nicotine addiction_Homo sapiens_hsa05033 | 0.57610552 |
| 83 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57172786 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.57029980 |
| 85 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.55897545 |
| 86 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.51199852 |
| 87 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.50980200 |
| 88 | Axon guidance_Homo sapiens_hsa04360 | 0.50642790 |
| 89 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.48499022 |
| 90 | Renin secretion_Homo sapiens_hsa04924 | 0.44218433 |
| 91 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.43799326 |
| 92 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.43768615 |
| 93 | Prion diseases_Homo sapiens_hsa05020 | 0.41651935 |
| 94 | Shigellosis_Homo sapiens_hsa05131 | 0.39267685 |
| 95 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.39010261 |
| 96 | Bladder cancer_Homo sapiens_hsa05219 | 0.37250071 |
| 97 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.36166042 |
| 98 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.35184403 |
| 99 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.34608409 |
| 100 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.33064291 |

