MRGPRE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.60585001
2doxorubicin metabolic process (GO:0044598)8.60585001
3daunorubicin metabolic process (GO:0044597)8.60585001
4aminoglycoside antibiotic metabolic process (GO:0030647)5.22420377
5detection of molecule of bacterial origin (GO:0032490)4.94344198
6G-protein coupled receptor internalization (GO:0002031)3.92566496
7auditory receptor cell stereocilium organization (GO:0060088)3.88580799
8energy homeostasis (GO:0097009)3.81367146
9negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77876387
10opioid receptor signaling pathway (GO:0038003)3.51571235
11inner ear receptor stereocilium organization (GO:0060122)3.49052018
12drinking behavior (GO:0042756)3.47920067
13detection of external biotic stimulus (GO:0098581)3.45816787
14cellular anion homeostasis (GO:0030002)3.45460479
15sulfate transmembrane transport (GO:1902358)3.42654358
16positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31343946
17positive regulation of uterine smooth muscle contraction (GO:0070474)3.31094648
18positive regulation of heat generation (GO:0031652)3.23804054
19prostate gland growth (GO:0060736)3.21772941
20positive regulation of cellular amide metabolic process (GO:0034250)3.14750271
21regulation of fever generation (GO:0031620)3.13767219
22mesenchymal cell differentiation involved in renal system development (GO:2001012)3.10943711
23mesenchymal cell differentiation involved in kidney development (GO:0072161)3.10943711
24detection of biotic stimulus (GO:0009595)3.09103264
25regulation of non-canonical Wnt signaling pathway (GO:2000050)3.07110366
26sulfate transport (GO:0008272)3.03986789
27ganglion development (GO:0061548)2.98914213
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86145126
29extracellular regulation of signal transduction (GO:1900115)2.85359168
30extracellular negative regulation of signal transduction (GO:1900116)2.85359168
31regulation of somitogenesis (GO:0014807)2.79857458
32embryonic camera-type eye morphogenesis (GO:0048596)2.79546606
33superoxide anion generation (GO:0042554)2.75286902
34histone H3-K36 demethylation (GO:0070544)2.75199049
35histone H3-K4 trimethylation (GO:0080182)2.67202399
36negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67098508
37negative regulation of stem cell proliferation (GO:2000647)2.62328140
38serotonin receptor signaling pathway (GO:0007210)2.62258517
39behavioral response to nicotine (GO:0035095)2.61115494
40urinary tract smooth muscle contraction (GO:0014848)2.58240904
41neuron remodeling (GO:0016322)2.57948112
42regulation of uterine smooth muscle contraction (GO:0070472)2.57656269
43positive regulation of interleukin-1 beta secretion (GO:0050718)2.56775466
44kidney morphogenesis (GO:0060993)2.55294146
45cerebral cortex radially oriented cell migration (GO:0021799)2.52054841
46positive regulation of icosanoid secretion (GO:0032305)2.50062368
47positive regulation of vascular permeability (GO:0043117)2.49289024
48negative regulation of mast cell activation (GO:0033004)2.48819715
49mesenchymal cell differentiation (GO:0048762)2.48774306
50neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.48496080
51trivalent inorganic anion homeostasis (GO:0072506)2.48425756
52phosphate ion homeostasis (GO:0055062)2.48425756
53post-embryonic morphogenesis (GO:0009886)2.48119656
54positive regulation of CREB transcription factor activity (GO:0032793)2.47442181
55positive regulation of prostaglandin secretion (GO:0032308)2.45728294
56regulation of heat generation (GO:0031650)2.45215876
57regulation of interleukin-6 biosynthetic process (GO:0045408)2.43036630
58regulation of icosanoid secretion (GO:0032303)2.41108066
59replicative senescence (GO:0090399)2.40660255
60synaptic vesicle docking involved in exocytosis (GO:0016081)2.39950159
61cell differentiation involved in metanephros development (GO:0072202)2.39918786
62axon extension involved in axon guidance (GO:0048846)2.39201485
63neuron projection extension involved in neuron projection guidance (GO:1902284)2.39201485
64venous blood vessel morphogenesis (GO:0048845)2.38545043
65tachykinin receptor signaling pathway (GO:0007217)2.36215982
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34169771
67response to host immune response (GO:0052572)2.34169771
68modulation by virus of host process (GO:0019054)2.33359165
69negative regulation of keratinocyte proliferation (GO:0010839)2.33111956
70bone remodeling (GO:0046849)2.32899737
71lateral ventricle development (GO:0021670)2.32254532
72startle response (GO:0001964)2.31595481
73positive regulation of interleukin-1 secretion (GO:0050716)2.31125646
74regulation of activation of Janus kinase activity (GO:0010533)2.29973433
75presynaptic membrane assembly (GO:0097105)2.29008482
76interferon-gamma production (GO:0032609)2.28721877
77regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.28689610
78developmental pigmentation (GO:0048066)2.28131354
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27331476
80dentate gyrus development (GO:0021542)2.24024246
81regulation of mitotic spindle checkpoint (GO:1903504)2.23101460
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.23101460
83postsynaptic membrane organization (GO:0001941)2.23048826
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.22661933
85synaptic vesicle endocytosis (GO:0048488)2.22640600
86glycosphingolipid biosynthetic process (GO:0006688)2.21650334
87positive regulation of protein sumoylation (GO:0033235)2.21591576
88positive regulation of action potential (GO:0045760)2.20724756
89macrophage activation (GO:0042116)2.20681809
90histamine secretion (GO:0001821)2.20371640
91monocyte chemotaxis (GO:0002548)2.19236536
92head development (GO:0060322)2.18113518
93glycoside metabolic process (GO:0016137)2.14978607
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13752033
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.13752033
96modulation by symbiont of host immune response (GO:0052553)2.13752033
97positive regulation by symbiont of host defense response (GO:0052509)2.13752033
98modulation by symbiont of host defense response (GO:0052031)2.13752033
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13752033
100response to pheromone (GO:0019236)10.6161834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.14435206
2EZH2_22144423_ChIP-Seq_EOC_Human3.66618710
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75491432
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.73966942
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48250529
6IGF1R_20145208_ChIP-Seq_DFB_Human2.46671017
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37952950
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23831958
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14612261
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.12058379
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06625729
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.01900947
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01130095
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.00820157
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00760651
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00550653
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95344310
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94204938
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.93660210
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.92360105
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91902955
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90944709
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.89202435
24P300_19829295_ChIP-Seq_ESCs_Human1.88583568
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86971777
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81527707
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81465919
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81226669
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77688004
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.76953560
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.75063801
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73031184
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70486260
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.70321383
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69155540
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69155540
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.68530255
38TAF15_26573619_Chip-Seq_HEK293_Human1.66457771
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66364861
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.62448655
41SMAD4_21799915_ChIP-Seq_A2780_Human1.62166565
42P53_22387025_ChIP-Seq_ESCs_Mouse1.59963808
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58323449
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58005731
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.57599456
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56176078
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55224290
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53122845
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.51106774
50RNF2_27304074_Chip-Seq_NSC_Mouse1.47404389
51DROSHA_22980978_ChIP-Seq_HELA_Human1.46261264
52NMYC_18555785_Chip-Seq_ESCs_Mouse1.46229219
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45978895
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.44840525
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40602873
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.36513335
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.36374976
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36274015
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.36094629
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35365951
61P300_18555785_Chip-Seq_ESCs_Mouse1.35048721
62ER_23166858_ChIP-Seq_MCF-7_Human1.34751230
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34551247
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34219438
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34116736
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32266925
67STAT3_23295773_ChIP-Seq_U87_Human1.32004715
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.31539378
69PU1_27457419_Chip-Seq_LIVER_Mouse1.30299168
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30177115
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.28461831
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27552980
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27424532
74EWS_26573619_Chip-Seq_HEK293_Human1.26354533
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.25780883
76AR_25329375_ChIP-Seq_VCAP_Human1.25445446
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25371636
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24846925
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.24369900
80TCF4_23295773_ChIP-Seq_U87_Human1.23583506
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22042366
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.21976187
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21262288
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21262288
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20663590
86RUNX2_22187159_ChIP-Seq_PCA_Human1.20583589
87FUS_26573619_Chip-Seq_HEK293_Human1.20253908
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20077062
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20069101
90RXR_22108803_ChIP-Seq_LS180_Human1.19097513
91AR_21572438_ChIP-Seq_LNCaP_Human1.18343388
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18082407
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16933966
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16256779
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13791971
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13768614
97* TP53_18474530_ChIP-ChIP_U2OS_Human1.11560837
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10578985
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10296682
100KDM2B_26808549_Chip-Seq_REH_Human1.09980199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.58872586
2MP0005645_abnormal_hypothalamus_physiol4.11095614
3MP0001986_abnormal_taste_sensitivity3.63105931
4MP0006292_abnormal_olfactory_placode3.44120819
5MP0005257_abnormal_intraocular_pressure3.18605758
6MP0001188_hyperpigmentation3.03977409
7MP0005646_abnormal_pituitary_gland2.57092452
8MP0002277_abnormal_respiratory_mucosa2.54761839
9MP0002163_abnormal_gland_morphology2.47556906
10MP0006276_abnormal_autonomic_nervous2.45525454
11MP0005423_abnormal_somatic_nervous2.36640015
12MP0003122_maternal_imprinting2.35244821
13MP0003787_abnormal_imprinting2.33989703
14MP0009697_abnormal_copulation2.33527068
15MP0005171_absent_coat_pigmentation2.30202100
16MP0005379_endocrine/exocrine_gland_phen2.23600760
17MP0001346_abnormal_lacrimal_gland2.16400860
18MP0008004_abnormal_stomach_pH2.10098656
19MP0002735_abnormal_chemical_nociception2.08362217
20MP0003878_abnormal_ear_physiology2.04839784
21MP0005377_hearing/vestibular/ear_phenot2.04839784
22MP0000569_abnormal_digit_pigmentation2.00339471
23MP0000678_abnormal_parathyroid_gland1.90680995
24MP0010386_abnormal_urinary_bladder1.86787938
25MP0002938_white_spotting1.86074109
26MP0002102_abnormal_ear_morphology1.73313468
27MP0002638_abnormal_pupillary_reflex1.72654306
28MP0001486_abnormal_startle_reflex1.69238525
29MP0000681_abnormal_thyroid_gland1.63933855
30MP0002396_abnormal_hematopoietic_system1.55366149
31MP0003868_abnormal_feces_composition1.46884325
32MP0001968_abnormal_touch/_nociception1.45899876
33MP0005310_abnormal_salivary_gland1.45637704
34MP0004742_abnormal_vestibular_system1.44447966
35MP0003941_abnormal_skin_development1.43612703
36MP0002736_abnormal_nociception_after1.43339230
37MP0003183_abnormal_peptide_metabolism1.36721134
38MP0003121_genomic_imprinting1.32188821
39MP0000015_abnormal_ear_pigmentation1.31963323
40MP0002557_abnormal_social/conspecific_i1.27528517
41MP0002572_abnormal_emotion/affect_behav1.21465154
42MP0003880_abnormal_central_pattern1.18105827
43MP0005503_abnormal_tendon_morphology1.15906899
44MP0004859_abnormal_synaptic_plasticity1.14792109
45MP0002132_abnormal_respiratory_system1.13263583
46MP0003172_abnormal_lysosome_physiology1.11160869
47MP0003879_abnormal_hair_cell1.09478754
48MP0005248_abnormal_Harderian_gland1.08847891
49MP0009745_abnormal_behavioral_response1.06955539
50MP0002734_abnormal_mechanical_nocicepti1.05361729
51MP0001501_abnormal_sleep_pattern1.02530708
52MP0000372_irregular_coat_pigmentation1.01299794
53MP0000631_abnormal_neuroendocrine_gland1.00821018
54MP0002876_abnormal_thyroid_physiology1.00792727
55MP0005409_darkened_coat_color1.00648574
56MP0000049_abnormal_middle_ear0.98103593
57MP0003045_fibrosis0.97788404
58MP0009046_muscle_twitch0.97777873
59MP0001502_abnormal_circadian_rhythm0.96605014
60MP0001970_abnormal_pain_threshold0.96560570
61MP0009250_abnormal_appendicular_skeleto0.96464039
62MP0002095_abnormal_skin_pigmentation0.95740004
63MP0001835_abnormal_antigen_presentation0.91876218
64MP0002998_abnormal_bone_remodeling0.91863565
65MP0000026_abnormal_inner_ear0.90616639
66MP0001984_abnormal_olfaction0.90279593
67MP0002184_abnormal_innervation0.88392181
68MP0002148_abnormal_hypersensitivity_rea0.87729320
69MP0005671_abnormal_response_to0.87438019
70MP0001963_abnormal_hearing_physiology0.87428358
71MP0002693_abnormal_pancreas_physiology0.86065577
72MP0000613_abnormal_salivary_gland0.82156191
73MP0001440_abnormal_grooming_behavior0.81667348
74MP0002063_abnormal_learning/memory/cond0.80428274
75MP0002067_abnormal_sensory_capabilities0.79367513
76MP0001270_distended_abdomen0.79334084
77MP0001186_pigmentation_phenotype0.79316382
78MP0002751_abnormal_autonomic_nervous0.79077573
79MP0001790_abnormal_immune_system0.78024869
80MP0005387_immune_system_phenotype0.78024869
81MP0003635_abnormal_synaptic_transmissio0.77408633
82MP0005174_abnormal_tail_pigmentation0.77222289
83MP0005670_abnormal_white_adipose0.76809971
84MP0001529_abnormal_vocalization0.76380297
85MP0004782_abnormal_surfactant_physiolog0.75370912
86MP0001299_abnormal_eye_distance/0.75313665
87MP0002075_abnormal_coat/hair_pigmentati0.73219066
88MP0003385_abnormal_body_wall0.72935195
89MP0004134_abnormal_chest_morphology0.72746508
90MP0002928_abnormal_bile_duct0.72399235
91MP0002249_abnormal_larynx_morphology0.70130998
92MP0002109_abnormal_limb_morphology0.68084073
93MP0000778_abnormal_nervous_system0.67274561
94MP0000538_abnormal_urinary_bladder0.67218029
95MP0002113_abnormal_skeleton_development0.66848305
96MP0002177_abnormal_outer_ear0.66399675
97MP0002064_seizures0.65894389
98MP0002116_abnormal_craniofacial_bone0.65480947
99MP0002272_abnormal_nervous_system0.64981926
100MP0001664_abnormal_digestion0.62262556

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)4.05304096
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99937655
3Febrile seizures (HP:0002373)3.87164534
4Prostate neoplasm (HP:0100787)3.70016326
5Patchy hypopigmentation of hair (HP:0011365)3.55376986
6Chromsome breakage (HP:0040012)3.55284134
7Absent eyebrow (HP:0002223)3.48322720
8White forelock (HP:0002211)3.47061074
9Abnormality of incisor morphology (HP:0011063)3.34447870
10Cheilitis (HP:0100825)3.23036707
11Osteomalacia (HP:0002749)3.21667973
12Congenital sensorineural hearing impairment (HP:0008527)3.19706846
13Aplasia cutis congenita (HP:0001057)3.08203627
14Parakeratosis (HP:0001036)3.00607343
15Septo-optic dysplasia (HP:0100842)2.98906731
16Chronic hepatic failure (HP:0100626)2.97063777
17Follicular hyperkeratosis (HP:0007502)2.82335352
18Abnormal hair whorl (HP:0010721)2.76505731
19Abnormality of dental color (HP:0011073)2.68585547
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.65900500
21Absent/shortened dynein arms (HP:0200106)2.65900500
22True hermaphroditism (HP:0010459)2.55252117
23Alopecia of scalp (HP:0002293)2.53776923
24Abnormality of the renal collecting system (HP:0004742)2.52698961
25Abnormality of the right ventricle (HP:0001707)2.52149992
26Hyperphosphatemia (HP:0002905)2.51507423
27Ectopic kidney (HP:0000086)2.44901621
28Duplicated collecting system (HP:0000081)2.41303182
29Focal motor seizures (HP:0011153)2.41033141
30Alveolar cell carcinoma (HP:0006519)2.35636975
31Pancreatic fibrosis (HP:0100732)2.33681478
32Hypothermia (HP:0002045)2.33631093
33Recurrent pneumonia (HP:0006532)2.30764732
34Abnormality of calcium-phosphate metabolism (HP:0100530)2.24134212
35Abnormality of the intervertebral disk (HP:0005108)2.24117210
36Renal dysplasia (HP:0000110)2.20049972
37Neoplasm of the tracheobronchial system (HP:0100552)2.18902302
38Decreased central vision (HP:0007663)2.15986477
39Recurrent cutaneous fungal infections (HP:0011370)2.13591685
40Chronic mucocutaneous candidiasis (HP:0002728)2.13591685
41Hip dysplasia (HP:0001385)2.12811523
42Conical tooth (HP:0000698)2.09222952
43Retrobulbar optic neuritis (HP:0100654)2.09119088
44Optic neuritis (HP:0100653)2.09119088
45Bilateral sensorineural hearing impairment (HP:0008619)2.08185535
46Bile duct proliferation (HP:0001408)2.06463314
47Abnormal biliary tract physiology (HP:0012439)2.06463314
48Abnormality of the prostate (HP:0008775)2.06386033
49Abnormality of the nasal septum (HP:0000419)2.06039111
50Recurrent corneal erosions (HP:0000495)2.04005401
51Large eyes (HP:0001090)1.97151527
52Conjugated hyperbilirubinemia (HP:0002908)1.96615666
53Absent eyelashes (HP:0000561)1.96166481
54Increased number of teeth (HP:0011069)1.95582870
55Cystic liver disease (HP:0006706)1.94206255
56Hyperactive renin-angiotensin system (HP:0000841)1.90930222
57Tubulointerstitial nephritis (HP:0001970)1.88162157
58Pancreatic cysts (HP:0001737)1.88087484
59Oligohydramnios (HP:0001562)1.88087292
60Abnormal ciliary motility (HP:0012262)1.86581759
61Chronic diarrhea (HP:0002028)1.86540693
62Clubbing of toes (HP:0100760)1.86280252
63Abnormality of the incisor (HP:0000676)1.85915455
64Tetany (HP:0001281)1.84860265
65Abnormality of DNA repair (HP:0003254)1.84033859
66Anomalous pulmonary venous return (HP:0010772)1.83206170
67Neoplasm of the lung (HP:0100526)1.81747645
68Optic nerve hypoplasia (HP:0000609)1.81509111
69Bone pain (HP:0002653)1.81179827
70Bradycardia (HP:0001662)1.79793503
71Cutaneous finger syndactyly (HP:0010554)1.79418235
72Midline defect of the nose (HP:0004122)1.78582176
73Ectropion (HP:0000656)1.78274597
74Narrow nasal bridge (HP:0000446)1.77712505
75Recurrent abscess formation (HP:0002722)1.77213129
76Keratitis (HP:0000491)1.76553688
77Aplasia/Hypoplasia of the fovea (HP:0008060)1.75802612
78Hypoplasia of the fovea (HP:0007750)1.75802612
79Congenital hepatic fibrosis (HP:0002612)1.75732102
80Abnormality of the parietal bone (HP:0002696)1.75179095
81Tetraparesis (HP:0002273)1.73165848
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.69543676
83Myelomeningocele (HP:0002475)1.67183447
84Congenital stationary night blindness (HP:0007642)1.66560521
85Preaxial hand polydactyly (HP:0001177)1.65799906
86Lip pit (HP:0100267)1.65456764
87Decreased circulating renin level (HP:0003351)1.64346071
88Abnormality of the renal medulla (HP:0100957)1.64277807
89Hyperaldosteronism (HP:0000859)1.62980330
90Cutaneous syndactyly (HP:0012725)1.62425940
91Small hand (HP:0200055)1.62116530
92Protruding tongue (HP:0010808)1.62095779
93Mesomelia (HP:0003027)1.61686755
94Recurrent lower respiratory tract infections (HP:0002783)1.60412489
95Molar tooth sign on MRI (HP:0002419)1.59182500
96Abnormality of midbrain morphology (HP:0002418)1.59182500
97Epileptic encephalopathy (HP:0200134)1.58795305
98Hypergonadotropic hypogonadism (HP:0000815)1.56406469
99Mitral stenosis (HP:0001718)1.56087938
100Hypoplastic iliac wings (HP:0002866)1.55829195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.99311377
2INSRR3.45112036
3SIK23.42975256
4CDK83.20617579
5CASK2.81754563
6TNIK2.66850535
7TXK2.56435289
8ADRBK22.38643241
9ZAK2.30181954
10SIK12.26268883
11NTRK32.15531018
12MAP2K71.82942669
13PRPF4B1.77706225
14MAP3K141.67563989
15MAPK131.66975468
16BMPR1B1.61627727
17IRAK31.60878972
18BRD41.60489998
19MARK31.58490619
20EIF2AK21.53704068
21SGK21.49234577
22TEC1.48668175
23CDK121.44134298
24IRAK41.42499294
25GRK71.34716004
26MAP3K131.30363591
27CDK31.29235563
28YES11.29230044
29BMPR21.21559280
30STK38L1.20928855
31MKNK21.15410776
32MAP3K121.13521722
33LATS11.03590898
34RIPK40.97498293
35ERBB30.93367274
36AKT30.90787560
37EPHA20.89229687
38CAMK1D0.88778282
39TNK20.87564499
40EPHA30.85970527
41MARK10.84697939
42SGK4940.80575566
43SGK2230.80575566
44SGK30.78367322
45TIE10.76708080
46STK160.76285053
47PLK20.74010053
48NUAK10.73800278
49SRPK10.73435438
50MARK20.72909689
51BLK0.71677040
52CAMK1G0.71655023
53CAMK10.69546936
54PRKCE0.69085952
55KIT0.64756619
56IKBKB0.64451938
57JAK10.63286199
58CAMK40.60630393
59CHEK20.60314991
60NEK60.60243912
61NTRK20.58880421
62SYK0.58838199
63MAPK70.58170788
64IRAK10.57720291
65GRK10.57665109
66SGK10.55176672
67LYN0.55124112
68TAOK20.53907326
69CHUK0.53278747
70WNK10.52667750
71TAOK30.52054943
72WNK30.51592018
73ATR0.50441327
74PRKAA20.47203365
75IRAK20.46106886
76STK380.45684885
77PKN10.45646788
78TGFBR20.45303460
79MAPK150.45049388
80IKBKE0.42522370
81MAP3K40.41480105
82ITK0.40274884
83CDC42BPA0.39979826
84PRKG10.39791342
85FRK0.39643727
86CDK70.38751094
87PRKCG0.38611163
88HCK0.38027605
89PRKCH0.37352096
90EPHB20.37005657
91NLK0.36697573
92MKNK10.36251144
93MAPK110.35460118
94VRK10.34486745
95EPHA40.30227590
96BTK0.29066569
97IGF1R0.28969716
98PIK3CA0.28379016
99DYRK1A0.28366070
100JAK30.27644714

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.56942720
2Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11828940
3Taste transduction_Homo sapiens_hsa047421.94613403
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90496928
5Morphine addiction_Homo sapiens_hsa050321.67334919
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67196512
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58527827
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56777779
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.55810571
10Serotonergic synapse_Homo sapiens_hsa047261.50219410
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.47692606
12Rheumatoid arthritis_Homo sapiens_hsa053231.44025689
13Primary immunodeficiency_Homo sapiens_hsa053401.43092980
14Hematopoietic cell lineage_Homo sapiens_hsa046401.40521899
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39943802
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39521461
17Insulin secretion_Homo sapiens_hsa049111.36451714
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35359417
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28553293
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24944094
21Autoimmune thyroid disease_Homo sapiens_hsa053201.24338728
22Synaptic vesicle cycle_Homo sapiens_hsa047211.22685480
23Circadian entrainment_Homo sapiens_hsa047131.20647291
24Type I diabetes mellitus_Homo sapiens_hsa049401.17757268
25Fanconi anemia pathway_Homo sapiens_hsa034601.17178889
26Measles_Homo sapiens_hsa051621.16424374
27Type II diabetes mellitus_Homo sapiens_hsa049301.15946130
28Calcium signaling pathway_Homo sapiens_hsa040201.14943461
29Olfactory transduction_Homo sapiens_hsa047401.12847558
30Graft-versus-host disease_Homo sapiens_hsa053321.12708112
31Melanoma_Homo sapiens_hsa052181.11433267
32Cholinergic synapse_Homo sapiens_hsa047251.11254214
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09480011
34GABAergic synapse_Homo sapiens_hsa047271.05996957
35Cocaine addiction_Homo sapiens_hsa050301.03766196
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.03613081
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.02638644
38Axon guidance_Homo sapiens_hsa043600.99854970
39Allograft rejection_Homo sapiens_hsa053300.98946146
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98049804
41Glutamatergic synapse_Homo sapiens_hsa047240.97735406
42Osteoclast differentiation_Homo sapiens_hsa043800.97481137
43Sphingolipid metabolism_Homo sapiens_hsa006000.96025410
44Basal transcription factors_Homo sapiens_hsa030220.94012934
45TNF signaling pathway_Homo sapiens_hsa046680.91903847
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90241400
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.87555822
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86602344
49Leishmaniasis_Homo sapiens_hsa051400.85825404
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84721728
51Tuberculosis_Homo sapiens_hsa051520.83929887
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83909169
53Prolactin signaling pathway_Homo sapiens_hsa049170.82383920
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82370374
55Circadian rhythm_Homo sapiens_hsa047100.80926740
56Ovarian steroidogenesis_Homo sapiens_hsa049130.80819947
57Phototransduction_Homo sapiens_hsa047440.80716004
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80210981
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80017700
60African trypanosomiasis_Homo sapiens_hsa051430.79856017
61Phagosome_Homo sapiens_hsa041450.79688833
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77917274
63cAMP signaling pathway_Homo sapiens_hsa040240.77740218
64Notch signaling pathway_Homo sapiens_hsa043300.77312319
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76248654
66Mineral absorption_Homo sapiens_hsa049780.75244086
67Homologous recombination_Homo sapiens_hsa034400.73454310
68Influenza A_Homo sapiens_hsa051640.73161742
69Ras signaling pathway_Homo sapiens_hsa040140.72056846
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72009925
71Chemokine signaling pathway_Homo sapiens_hsa040620.71711433
72Herpes simplex infection_Homo sapiens_hsa051680.71526019
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71419933
74Amphetamine addiction_Homo sapiens_hsa050310.69526786
75Renin secretion_Homo sapiens_hsa049240.69213946
76Wnt signaling pathway_Homo sapiens_hsa043100.67917037
77Dopaminergic synapse_Homo sapiens_hsa047280.67435715
78Other glycan degradation_Homo sapiens_hsa005110.67136513
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63849187
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62945812
81Salivary secretion_Homo sapiens_hsa049700.62112226
82Collecting duct acid secretion_Homo sapiens_hsa049660.61596895
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61476789
84Malaria_Homo sapiens_hsa051440.59266585
85Long-term depression_Homo sapiens_hsa047300.59120033
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58976916
87MAPK signaling pathway_Homo sapiens_hsa040100.58613555
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58342433
89Asthma_Homo sapiens_hsa053100.57409517
90B cell receptor signaling pathway_Homo sapiens_hsa046620.56860053
91Hepatitis B_Homo sapiens_hsa051610.55946092
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55834964
93T cell receptor signaling pathway_Homo sapiens_hsa046600.55518087
94Pancreatic cancer_Homo sapiens_hsa052120.55274428
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54351531
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54344097
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53406755
98ErbB signaling pathway_Homo sapiens_hsa040120.53363479
99Regulation of autophagy_Homo sapiens_hsa041400.53140956
100Non-homologous end-joining_Homo sapiens_hsa034500.51569289

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