MRGPRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.58462570
2collagen fibril organization (GO:0030199)6.81773527
3epoxygenase P450 pathway (GO:0019373)5.95547735
4omega-hydroxylase P450 pathway (GO:0097267)5.56875495
5glomerular visceral epithelial cell development (GO:0072015)5.50573565
6skin morphogenesis (GO:0043589)5.26699864
7glomerular basement membrane development (GO:0032836)5.25240241
8sequestering of extracellular ligand from receptor (GO:0035581)5.09340337
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.94422214
10collagen metabolic process (GO:0032963)4.88442877
11collagen catabolic process (GO:0030574)4.77981034
12glomerular epithelial cell development (GO:0072310)4.76566538
13multicellular organismal macromolecule metabolic process (GO:0044259)4.64302634
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.60662652
15positive regulation of endothelial cell apoptotic process (GO:2000353)4.59745130
16extracellular fibril organization (GO:0043206)4.52199689
17epithelial cell-cell adhesion (GO:0090136)4.50005602
18endodermal cell differentiation (GO:0035987)4.47406364
19chondrocyte proliferation (GO:0035988)4.47280570
20adhesion of symbiont to host (GO:0044406)4.46387483
21multicellular organismal catabolic process (GO:0044243)4.46196595
22fibril organization (GO:0097435)4.41611184
23multicellular organismal metabolic process (GO:0044236)4.37289234
24negative regulation of smooth muscle cell migration (GO:0014912)4.29184826
25bone trabecula formation (GO:0060346)4.23540010
26endothelial cell chemotaxis (GO:0035767)4.16512730
27extracellular matrix disassembly (GO:0022617)4.11539214
28endocardial cushion development (GO:0003197)4.11278272
29basement membrane organization (GO:0071711)3.99363246
30extracellular matrix assembly (GO:0085029)3.98247968
31keratan sulfate catabolic process (GO:0042340)3.94575822
32negative regulation of chondrocyte differentiation (GO:0032331)3.92565840
33cell adhesion mediated by integrin (GO:0033627)3.87485478
34wound healing, spreading of cells (GO:0044319)3.83386695
35barbed-end actin filament capping (GO:0051016)3.81157337
36wound healing, spreading of epidermal cells (GO:0035313)3.80229543
37dermatan sulfate biosynthetic process (GO:0030208)3.76386125
38peptidyl-proline hydroxylation (GO:0019511)3.73237399
39positive regulation of extracellular matrix organization (GO:1903055)3.70859477
40axon extension involved in axon guidance (GO:0048846)3.69308704
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.69308704
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58051225
43protein targeting to plasma membrane (GO:0072661)3.49792575
44apoptotic cell clearance (GO:0043277)3.45240629
45plasma membrane repair (GO:0001778)3.42993119
46extracellular matrix organization (GO:0030198)3.39606675
47extracellular structure organization (GO:0043062)3.38207469
48dermatan sulfate metabolic process (GO:0030205)3.37567000
49protein hydroxylation (GO:0018126)3.29921518
50negative regulation of catenin import into nucleus (GO:0035414)3.29726076
51hyaluronan catabolic process (GO:0030214)3.28306419
52regulation of integrin-mediated signaling pathway (GO:2001044)3.26129120
53middle ear morphogenesis (GO:0042474)3.19775290
54mesenchymal-epithelial cell signaling (GO:0060638)3.17236760
55G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.17014476
56regulation of extracellular matrix disassembly (GO:0010715)3.15831949
57chondroitin sulfate biosynthetic process (GO:0030206)3.15426143
58paraxial mesoderm development (GO:0048339)3.13329084
59smooth muscle tissue development (GO:0048745)3.10989795
60regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.10907620
61regulation of tight junction assembly (GO:2000810)3.10409046
62cortical actin cytoskeleton organization (GO:0030866)3.10333314
63vascular endothelial growth factor signaling pathway (GO:0038084)3.07731163
64heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.06733939
65negative regulation of cartilage development (GO:0061037)3.05251065
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04408584
67cell-substrate junction assembly (GO:0007044)3.04082645
68protein localization to cell surface (GO:0034394)3.03598223
69regulation of plasminogen activation (GO:0010755)3.02216178
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.01863949
71extracellular negative regulation of signal transduction (GO:1900116)3.00500093
72extracellular regulation of signal transduction (GO:1900115)3.00500093
73tooth mineralization (GO:0034505)2.99209005
74venous blood vessel morphogenesis (GO:0048845)2.97790212
75negative regulation of osteoblast proliferation (GO:0033689)2.97467182
76protein retention in ER lumen (GO:0006621)2.96754904
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95452778
78negative regulation of BMP signaling pathway (GO:0030514)2.93967596
79adherens junction assembly (GO:0034333)2.93745066
80cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.93038759
81cell migration involved in sprouting angiogenesis (GO:0002042)2.92578595
82positive regulation of fibroblast migration (GO:0010763)2.91337340
83type B pancreatic cell proliferation (GO:0044342)2.89795933
84focal adhesion assembly (GO:0048041)2.88109606
85cell-substrate adherens junction assembly (GO:0007045)2.88109606
86cellular response to vitamin D (GO:0071305)2.87952757
87cell proliferation involved in metanephros development (GO:0072203)2.86647629
88stress fiber assembly (GO:0043149)2.86488561
89endothelial cell morphogenesis (GO:0001886)2.85995173
90hypotonic response (GO:0006971)2.85235918
91regulation of smooth muscle cell migration (GO:0014910)2.84910893
92positive regulation of epithelial to mesenchymal transition (GO:0010718)2.84407160
93metanephric mesenchyme development (GO:0072075)2.83991730
94substrate adhesion-dependent cell spreading (GO:0034446)2.82852877
95lymphangiogenesis (GO:0001946)2.82324241
96outer ear morphogenesis (GO:0042473)2.81026267
97kidney mesenchyme development (GO:0072074)2.79756704
98negative regulation of adherens junction organization (GO:1903392)2.79130941
99negative regulation of focal adhesion assembly (GO:0051895)2.79130941
100negative regulation of cell junction assembly (GO:1901889)2.79130941
101trabecula formation (GO:0060343)2.77683735
102muscle cell migration (GO:0014812)2.77571628
103craniofacial suture morphogenesis (GO:0097094)2.77471883
104positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.76948050
105pericardium development (GO:0060039)2.74862206
106blood vessel maturation (GO:0001955)2.74722793
107endocytic recycling (GO:0032456)2.73983754
108substrate-dependent cell migration (GO:0006929)2.72603931
109cellular response to amino acid stimulus (GO:0071230)2.72563028
110toxin metabolic process (GO:0009404)2.72011750
111cortical cytoskeleton organization (GO:0030865)2.71489769
112chondroitin sulfate catabolic process (GO:0030207)2.70876530
113positive regulation of p38MAPK cascade (GO:1900745)2.70010689
114negative regulation of fatty acid transport (GO:2000192)2.69800511
115cell-matrix adhesion (GO:0007160)2.68786022
116artery morphogenesis (GO:0048844)2.68557712
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68257498
118cell-substrate adhesion (GO:0031589)2.67074242
119cochlea morphogenesis (GO:0090103)2.66706152
120myelination in peripheral nervous system (GO:0022011)2.66496630
121peripheral nervous system axon ensheathment (GO:0032292)2.66496630
122positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64949663
123mesenchymal cell differentiation involved in kidney development (GO:0072161)2.64557813
124mesenchymal cell differentiation involved in renal system development (GO:2001012)2.64557813
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63579580
126wound healing (GO:0042060)2.62566221
127cellular response to interferon-alpha (GO:0035457)2.61671296
128hippo signaling (GO:0035329)2.61437448
129protein trimerization (GO:0070206)2.59871123
130cell migration involved in heart development (GO:0060973)2.59560048
131lung vasculature development (GO:0060426)2.59559384
132negative regulation of nitric-oxide synthase activity (GO:0051001)2.59074297
133lymph vessel development (GO:0001945)2.59055139
134negative regulation of leukocyte chemotaxis (GO:0002689)2.56410272
135anatomical structure regression (GO:0060033)2.56269767
136negative chemotaxis (GO:0050919)2.53961707
137planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52277971
138cellular response to vitamin (GO:0071295)2.52033307
139adhesion of symbiont to host cell (GO:0044650)2.51393037
140virion attachment to host cell (GO:0019062)2.51393037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.09687362
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.04729054
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.54063088
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.01975853
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23747741
6CLOCK_20551151_ChIP-Seq_293T_Human3.22562865
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.86207090
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.80533963
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.40918953
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.29327324
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.28997795
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28570882
13* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.27758697
14CJUN_26792858_Chip-Seq_BT549_Human2.23614844
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11861117
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.09366640
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07602960
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.00536848
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91517700
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91517700
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.91094524
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87110554
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.83421192
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.79985964
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79951547
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79951547
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79552967
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77556611
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73226461
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71310562
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70647233
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69657558
33BRD4_25478319_ChIP-Seq_HGPS_Human1.68188978
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67342472
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61508646
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58978732
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57471628
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55383041
39TP53_16413492_ChIP-PET_HCT116_Human1.53767727
40SMC1_22415368_ChIP-Seq_MEFs_Mouse1.52742914
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42652248
42* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40675849
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38130863
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35907768
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34636782
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34517845
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34435095
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33571592
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33499815
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.32113773
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.32113773
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31902646
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31621367
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30772578
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29892573
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28316716
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28246511
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27435727
59TP53_23651856_ChIP-Seq_MEFs_Mouse1.25437208
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25311520
61* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25307500
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24856981
63LXR_22292898_ChIP-Seq_THP-1_Human1.23476916
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.22359015
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22183281
66TP53_18474530_ChIP-ChIP_U2OS_Human1.21546832
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21430779
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20713224
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20187242
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18644358
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18233404
72RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18078343
73RACK7_27058665_Chip-Seq_MCF-7_Human1.17934684
74SOX2_20726797_ChIP-Seq_SW620_Human1.17410152
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.17309660
76KDM2B_26808549_Chip-Seq_K562_Human1.16533060
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16289561
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.15916416
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.14909957
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13859367
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12858637
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12120386
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11779821
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11779821
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11481746
86RXR_22108803_ChIP-Seq_LS180_Human1.08622533
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07151411
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04968087
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.04650045
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.04540221
91ATF3_27146783_Chip-Seq_COLON_Human1.04377648
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03338051
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02770520
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01566818
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.01324586
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01074640
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00845246
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.00689859
99SA1_22415368_ChIP-Seq_MEFs_Mouse0.99168551
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.98883567
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98560807
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98554916
103ISL1_27105846_Chip-Seq_CPCs_Mouse0.97667705
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95551115
105SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94991806
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94193069
107TP53_22127205_ChIP-Seq_IMR90_Human0.94025313
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93973049
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93400144
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92259195
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92224304
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89763501
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89738826
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89493115
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88730419
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88340387
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88154395
118* KDM2B_26808549_Chip-Seq_DND41_Human0.85973461
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.85951745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.55747435
2MP0005275_abnormal_skin_tensile5.65633560
3MP0003705_abnormal_hypodermis_morpholog5.45039455
4MP0005503_abnormal_tendon_morphology5.33634411
5MP0003279_aneurysm4.82524188
6MP0001958_emphysema3.94186724
7MP0009384_cardiac_valve_regurgitation3.64606801
8MP0004272_abnormal_basement_membrane2.93324058
9MP0005623_abnormal_meninges_morphology2.52984232
10MP0006054_spinal_hemorrhage2.27888192
11MP0005508_abnormal_skeleton_morphology2.11484692
12MP0002060_abnormal_skin_morphology2.05556490
13MP0002295_abnormal_pulmonary_circulatio2.05434714
14MP0003385_abnormal_body_wall1.78411660
15MP0005023_abnormal_wound_healing1.75933612
16MP0001542_abnormal_bone_strength1.73819270
17MP0002254_reproductive_system_inflammat1.70061482
18MP0003566_abnormal_cell_adhesion1.66334822
19MP0005257_abnormal_intraocular_pressure1.62619167
20MP0002108_abnormal_muscle_morphology1.61272410
21MP0001879_abnormal_lymphatic_vessel1.55874901
22MP0010030_abnormal_orbit_morphology1.53989497
23MP0000013_abnormal_adipose_tissue1.47893252
24MP0003091_abnormal_cell_migration1.47689350
25MP0003941_abnormal_skin_development1.46423943
26MP0000751_myopathy1.46352607
27MP0001243_abnormal_dermal_layer1.43665369
28MP0002933_joint_inflammation1.41191506
29MP0009250_abnormal_appendicular_skeleto1.39972603
30MP0002896_abnormal_bone_mineralization1.38637151
31MP0002877_abnormal_melanocyte_morpholog1.36481090
32MP0005390_skeleton_phenotype1.27624202
33MP0000767_abnormal_smooth_muscle1.27179644
34MP0010368_abnormal_lymphatic_system1.26755925
35MP0001849_ear_inflammation1.24954648
36MP0010386_abnormal_urinary_bladder1.23282936
37MP0003045_fibrosis1.22646186
38MP0001299_abnormal_eye_distance/1.22127852
39MP0002168_other_aberrant_phenotype1.19816552
40MP0004233_abnormal_muscle_weight1.17561047
41MP0004084_abnormal_cardiac_muscle1.16814961
42MP0008775_abnormal_heart_ventricle1.16012357
43MP0000534_abnormal_ureter_morphology1.15059803
44MP0000003_abnormal_adipose_tissue1.12870766
45MP0000163_abnormal_cartilage_morphology1.11653272
46MP0002837_dystrophic_cardiac_calcinosis1.09751077
47MP0000750_abnormal_muscle_regeneration1.06509154
48MP0000733_abnormal_muscle_development1.04469823
49MP0002932_abnormal_joint_morphology1.03267402
50MP0002115_abnormal_skeleton_extremities1.02418958
51MP0005171_absent_coat_pigmentation1.00140630
52MP0010352_gastrointestinal_tract_polyps0.98930040
53MP0009840_abnormal_foam_cell0.98692629
54MP0001533_abnormal_skeleton_physiology0.97574904
55MP0000749_muscle_degeneration0.95202158
56MP0005595_abnormal_vascular_smooth0.92493922
57MP0000759_abnormal_skeletal_muscle0.92457580
58MP0002282_abnormal_trachea_morphology0.90788620
59MP0002998_abnormal_bone_remodeling0.89324284
60MP0002128_abnormal_blood_circulation0.89255516
61MP0000462_abnormal_digestive_system0.87668940
62MP0004858_abnormal_nervous_system0.86669490
63MP0004134_abnormal_chest_morphology0.86490232
64MP0003950_abnormal_plasma_membrane0.85770945
65MP0005388_respiratory_system_phenotype0.84543027
66MP0002133_abnormal_respiratory_system0.84543027
67MP0005197_abnormal_uvea_morphology0.84443265
68MP0003942_abnormal_urinary_system0.82893173
69MP0002113_abnormal_skeleton_development0.82079016
70MP0003115_abnormal_respiratory_system0.80738737
71MP0002249_abnormal_larynx_morphology0.79258116
72MP0003283_abnormal_digestive_organ0.77961812
73MP0004087_abnormal_muscle_fiber0.76975668
74MP0000343_altered_response_to0.76453349
75MP0000538_abnormal_urinary_bladder0.76219302
76MP0001614_abnormal_blood_vessel0.76150473
77MP0006138_congestive_heart_failure0.75776496
78MP0005058_abnormal_lysosome_morphology0.75613165
79MP0009780_abnormal_chondrocyte_physiolo0.73133225
80MP0005076_abnormal_cell_differentiation0.71715141
81MP0005164_abnormal_response_to0.71329777
82MP0005369_muscle_phenotype0.70003528
83MP0000428_abnormal_craniofacial_morphol0.68915309
84MP0009053_abnormal_anal_canal0.67512280
85MP0003795_abnormal_bone_structure0.66478461
86MP0003448_altered_tumor_morphology0.65099146
87MP0001177_atelectasis0.64848433
88MP0005375_adipose_tissue_phenotype0.64695469
89MP0005670_abnormal_white_adipose0.64304278
90MP0000681_abnormal_thyroid_gland0.63898372
91MP0003755_abnormal_palate_morphology0.63883675
92MP0004883_abnormal_blood_vessel0.62821384
93MP0004036_abnormal_muscle_relaxation0.62478434
94MP0000049_abnormal_middle_ear0.62183748
95MP0000762_abnormal_tongue_morphology0.61514896
96MP0005620_abnormal_muscle_contractility0.61503025
97MP0002116_abnormal_craniofacial_bone0.61032957
98MP0001348_abnormal_lacrimal_gland0.60907915
99MP0001915_intracranial_hemorrhage0.59719828
100MP0002111_abnormal_tail_morphology0.59157265
101MP0000432_abnormal_head_morphology0.58858402
102MP0001175_abnormal_lung_morphology0.57833653
103MP0010771_integument_phenotype0.57689581
104MP0000747_muscle_weakness0.57615422
105MP0005165_increased_susceptibility_to0.57131651
106MP0000579_abnormal_nail_morphology0.56940273
107MP0003828_pulmonary_edema0.56929065
108MP0005330_cardiomyopathy0.56565757
109MP0002938_white_spotting0.56560293
110MP0003300_gastrointestinal_ulcer0.55373619
111MP0002109_abnormal_limb_morphology0.53821320
112MP0002114_abnormal_axial_skeleton0.53574258
113MP0001270_distended_abdomen0.51975262
114MP0008004_abnormal_stomach_pH0.47569461
115MP0000604_amyloidosis0.47026731
116MP0004510_myositis0.46317643
117MP0002089_abnormal_postnatal_growth/wei0.46302728
118MP0002127_abnormal_cardiovascular_syste0.46255236
119MP0003935_abnormal_craniofacial_develop0.46148183
120MP0000467_abnormal_esophagus_morphology0.46070673

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.42772051
2Premature rupture of membranes (HP:0001788)7.69610407
3Soft skin (HP:0000977)5.80909254
4Follicular hyperkeratosis (HP:0007502)5.52558927
5Bladder diverticulum (HP:0000015)5.19184736
6Aortic aneurysm (HP:0004942)5.12572613
7Ankle contracture (HP:0006466)5.11457570
8Aortic dissection (HP:0002647)4.90041941
9Shallow orbits (HP:0000586)4.59301194
10Atrophic scars (HP:0001075)4.57812268
11Peritonitis (HP:0002586)4.56248869
12Broad metatarsal (HP:0001783)4.51238258
13Vascular tortuosity (HP:0004948)4.23925277
14Overgrowth (HP:0001548)4.22820730
15Type 1 muscle fiber predominance (HP:0003803)4.22723454
16Cerebral aneurysm (HP:0004944)4.17220459
17Dilatation of the ascending aorta (HP:0005111)4.13429260
18Fragile skin (HP:0001030)4.08937263
19Wrist flexion contracture (HP:0001239)4.04576910
20Arterial tortuosity (HP:0005116)4.00033359
21Wormian bones (HP:0002645)3.99123704
22Spinal rigidity (HP:0003306)3.75407225
23Increased connective tissue (HP:0009025)3.69510853
24Vertebral compression fractures (HP:0002953)3.56371080
25Cervical subluxation (HP:0003308)3.50731830
26Abnormality of dentin (HP:0010299)3.48405594
27Biconcave vertebral bodies (HP:0004586)3.44295639
28Neonatal short-limb short stature (HP:0008921)3.25814142
29Blue sclerae (HP:0000592)3.25304025
30Bowel diverticulosis (HP:0005222)3.21613037
31Genu recurvatum (HP:0002816)3.18889499
32Hyperextensible skin (HP:0000974)3.18349390
33Slender build (HP:0001533)3.11544914
34Increased variability in muscle fiber diameter (HP:0003557)3.06765742
35Mitral valve prolapse (HP:0001634)3.01777539
36Aortic regurgitation (HP:0001659)2.87857082
37Aneurysm (HP:0002617)2.75228824
38Elbow flexion contracture (HP:0002987)2.74299561
39Abnormality of skeletal muscle fiber size (HP:0012084)2.73356071
40Infantile muscular hypotonia (HP:0008947)2.72839010
41Mildly elevated creatine phosphokinase (HP:0008180)2.69064165
42Buphthalmos (HP:0000557)2.62930397
43Joint stiffness (HP:0001387)2.60321315
44Spondylolisthesis (HP:0003302)2.58399126
45Abnormal delivery (HP:0001787)2.55187843
46Ectopia lentis (HP:0001083)2.50301319
47Coxa vara (HP:0002812)2.40256071
48Mesangial abnormality (HP:0001966)2.38957547
49Aortic valve stenosis (HP:0001650)2.33633325
50Long toe (HP:0010511)2.33128852
51Joint laxity (HP:0001388)2.30892313
52Abnormality of the acetabulum (HP:0003170)2.30580703
53Mild short stature (HP:0003502)2.30070470
54Thin bony cortex (HP:0002753)2.28869798
55Osteolytic defects of the hand bones (HP:0009699)2.23014985
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.23014985
57Congenital glaucoma (HP:0001087)2.22459054
58Hypoplasia of the iris (HP:0007676)2.19921386
59Achilles tendon contracture (HP:0001771)2.17407113
60Hypoventilation (HP:0002791)2.14687174
61Breech presentation (HP:0001623)2.14314734
62Round ear (HP:0100830)2.14197523
63Mesomelia (HP:0003027)2.13129773
64Broad ribs (HP:0000885)2.13057160
65Mitral regurgitation (HP:0001653)2.09770626
66Natal tooth (HP:0000695)2.05084860
67Disproportionate tall stature (HP:0001519)2.04838307
68Venous abnormality (HP:0002624)2.04077010
69Wide anterior fontanel (HP:0000260)2.03973114
70Redundant skin (HP:0001582)2.03675933
71Abnormality of the peritoneum (HP:0002585)2.01735023
72Nonimmune hydrops fetalis (HP:0001790)2.00489969
73Venous insufficiency (HP:0005293)1.99081313
74Generalized amyotrophy (HP:0003700)1.97358398
75Difficulty climbing stairs (HP:0003551)1.96466293
76Turricephaly (HP:0000262)1.95802201
77Distal upper limb amyotrophy (HP:0007149)1.95129470
78Upper limb amyotrophy (HP:0009129)1.95129470
79Alopecia of scalp (HP:0002293)1.94478299
80Thoracolumbar scoliosis (HP:0002944)1.93872636
81Abnormality of the Achilles tendon (HP:0005109)1.93641856
82Premature skin wrinkling (HP:0100678)1.93190779
83Absent frontal sinuses (HP:0002688)1.91571687
84Emphysema (HP:0002097)1.89829421
85Osteoarthritis (HP:0002758)1.88682321
86Bradycardia (HP:0001662)1.88346997
87Knee flexion contracture (HP:0006380)1.87929314
88Ovoid vertebral bodies (HP:0003300)1.86383796
89Limb-girdle muscle weakness (HP:0003325)1.85302892
90Asymmetry of the thorax (HP:0001555)1.83879533
91Deviation of the hallux (HP:0010051)1.83658566
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81411531
93Osteopenia (HP:0000938)1.81038687
94Coronal craniosynostosis (HP:0004440)1.80915569
95Inguinal hernia (HP:0000023)1.80099807
96Muscle fiber splitting (HP:0003555)1.79123094
97Beaking of vertebral bodies (HP:0004568)1.79085720
98Thin skin (HP:0000963)1.77744135
99Striae distensae (HP:0001065)1.75984158
100Hyporeflexia of lower limbs (HP:0002600)1.74741330
101Abnormality of skull ossification (HP:0002703)1.74590178
102Nephritis (HP:0000123)1.74083655
103Camptodactyly of toe (HP:0001836)1.73511141
104Deformed tarsal bones (HP:0008119)1.73302880
105Hand muscle atrophy (HP:0009130)1.71361495
106Decreased skull ossification (HP:0004331)1.71010048
107Hallux valgus (HP:0001822)1.70408666
108Hip contracture (HP:0003273)1.69962564
109Ulnar deviation of the wrist (HP:0003049)1.68977035
110Narrow nasal bridge (HP:0000446)1.67536844
111Joint contractures involving the joints of the feet (HP:0100492)1.67321385
112Flexion contracture of toe (HP:0005830)1.67321385
113Scapular winging (HP:0003691)1.66760797
114Short nail (HP:0001799)1.66750291
115Morphological abnormality of the middle ear (HP:0008609)1.66310902
116Tarsal synostosis (HP:0008368)1.65949248
117Platyspondyly (HP:0000926)1.65637154
118Gingival overgrowth (HP:0000212)1.64755182
119Renal duplication (HP:0000075)1.64565834
120Persistence of primary teeth (HP:0006335)1.64361401
121Broad long bones (HP:0005622)1.64190849
122Protruding ear (HP:0000411)1.64179790
123Femoral bowing (HP:0002980)1.63824555
124Delayed cranial suture closure (HP:0000270)1.62110510
125Ulnar bowing (HP:0003031)1.59416964
126Delayed closure of the anterior fontanelle (HP:0001476)1.58795888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.08776468
2TRIB34.05513550
3DDR23.83801536
4TTN3.76092093
5LATS23.51070300
6PDGFRA2.93998962
7CAMK1G2.58816235
8PKN22.48689859
9EPHB22.31186542
10MAP3K31.99244361
11PAK21.98915240
12PAK31.98025794
13RIPK11.95311702
14EPHB11.89370896
15SIK11.77722277
16MYLK1.77658787
17FER1.74453591
18GRK71.69349467
19GRK51.68725239
20DMPK1.62556887
21TESK11.62262403
22CAMK1D1.62083214
23CAMKK21.58619934
24TRPM71.55862662
25AKT31.55772399
26PTK2B1.53898177
27PTK21.53369397
28STK381.52304941
29PTK61.51690667
30PNCK1.50433546
31EPHA31.46341147
32BMX1.40802510
33LIMK11.40225809
34ROCK11.39313749
35LATS11.33484432
36TGFBR21.29977666
37PIM21.24710026
38PIK3CG1.21352596
39PAK41.20889326
40MOS1.19753131
41GRK11.18995242
42LRRK21.18726165
43MAP2K11.08343258
44RPS6KA41.03701488
45PIK3CA1.03256273
46MAP3K60.99122999
47NTRK10.97611949
48ADRBK20.95227635
49FGFR10.94986224
50MET0.94537956
51MAPKAPK30.92521494
52ROCK20.90228768
53TAOK20.90025613
54CAMKK10.86013106
55ILK0.84803412
56MTOR0.83192173
57PRPF4B0.81501369
58GRK60.80609261
59TAOK10.80166699
60SMG10.80076706
61PRKD10.78784263
62PDK20.77833142
63EEF2K0.76983617
64ICK0.76294245
65MARK20.72082587
66PAK60.71345717
67FLT30.71051715
68ERBB40.70629900
69DAPK30.70091178
70HIPK20.69560365
71RET0.68479480
72PAK10.68040879
73PDGFRB0.67858769
74LMTK20.65950609
75ERBB30.61966878
76ARAF0.61018031
77CDC42BPA0.60613836
78CAMK40.59306562
79SCYL20.59150077
80MELK0.58465003
81JAK10.58425299
82PLK20.56980730
83MAP2K30.56287431
84CAMK2G0.53410551
85CLK10.52064688
86TESK20.50785897
87NEK20.50714343
88RPS6KA20.49544437
89PRKD20.48381763
90NEK90.47518427
91WNK10.46583486
92PRKD30.46125085
93FGFR40.45705338
94CDK150.44770430
95STK30.44538902
96SRC0.44506977
97MAPK120.44440854
98CDK140.44248511
99PRKCH0.43920265
100INSR0.42640977
101DYRK1B0.41637628
102MAPK70.41306975
103MAP3K70.41277615
104KSR20.40953016
105ABL20.40894836
106BCKDK0.38788721
107PRKG20.38532520
108FRK0.38396096
109MAP2K20.38204419
110CDK11A0.38038973
111CAMK10.37919169
112RPS6KC10.37704023
113RPS6KL10.37704023
114CDK180.37366256
115MAPK40.36907792
116PDPK10.35219080
117MAPKAPK50.34414504
118ALK0.33941381
119CDK80.33777734
120TGFBR10.33735032
121RPS6KA60.33731817
122KIT0.32970925
123ADRBK10.32761631
124MAPK10.32547699
125GSK3A0.32193208
126MAPKAPK20.31644838
127TIE10.30768511
128TYK20.27866305
129JAK30.27168906
130TBK10.23713396
131MAP3K80.23122300
132BRAF0.23085915

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.62455551
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.13500445
3Protein digestion and absorption_Homo sapiens_hsa049743.05148619
4Focal adhesion_Homo sapiens_hsa045103.02160524
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.55417527
6Amoebiasis_Homo sapiens_hsa051462.43301401
7Dilated cardiomyopathy_Homo sapiens_hsa054142.25062187
8Proteoglycans in cancer_Homo sapiens_hsa052052.24823189
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.24290257
10Malaria_Homo sapiens_hsa051442.13309064
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99059935
12Adherens junction_Homo sapiens_hsa045201.85895697
13Bladder cancer_Homo sapiens_hsa052191.64284173
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59803551
15Small cell lung cancer_Homo sapiens_hsa052221.54166932
16TGF-beta signaling pathway_Homo sapiens_hsa043501.50326111
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.47970467
18Hedgehog signaling pathway_Homo sapiens_hsa043401.42221406
19Nitrogen metabolism_Homo sapiens_hsa009101.39975184
20Hippo signaling pathway_Homo sapiens_hsa043901.39070096
21Basal cell carcinoma_Homo sapiens_hsa052171.34085858
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27346668
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.20752690
24MicroRNAs in cancer_Homo sapiens_hsa052061.16823859
25Melanoma_Homo sapiens_hsa052181.14283986
26Viral myocarditis_Homo sapiens_hsa054161.11029757
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05700541
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01964165
29Tight junction_Homo sapiens_hsa045301.01416538
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98226633
31Thyroid hormone synthesis_Homo sapiens_hsa049180.96637361
32TNF signaling pathway_Homo sapiens_hsa046680.95933588
33Gap junction_Homo sapiens_hsa045400.95495934
34Leukocyte transendothelial migration_Homo sapiens_hsa046700.93218121
35Vascular smooth muscle contraction_Homo sapiens_hsa042700.91225604
36Glioma_Homo sapiens_hsa052140.90119951
37Chronic myeloid leukemia_Homo sapiens_hsa052200.89963289
38Pathways in cancer_Homo sapiens_hsa052000.89904595
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89694494
40Platelet activation_Homo sapiens_hsa046110.89001941
41Melanogenesis_Homo sapiens_hsa049160.85430791
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.84493577
43Pancreatic cancer_Homo sapiens_hsa052120.84392474
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82478019
45Lysosome_Homo sapiens_hsa041420.81715519
46Rap1 signaling pathway_Homo sapiens_hsa040150.81701332
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81512467
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81486657
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80768397
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77888227
51Pertussis_Homo sapiens_hsa051330.76774235
52Axon guidance_Homo sapiens_hsa043600.76763466
53Wnt signaling pathway_Homo sapiens_hsa043100.76224851
54HIF-1 signaling pathway_Homo sapiens_hsa040660.75655453
55Shigellosis_Homo sapiens_hsa051310.73804160
56Ovarian steroidogenesis_Homo sapiens_hsa049130.73142056
57Phagosome_Homo sapiens_hsa041450.70711963
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70455911
59Other glycan degradation_Homo sapiens_hsa005110.69727298
60GnRH signaling pathway_Homo sapiens_hsa049120.68097738
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67278164
62Renal cell carcinoma_Homo sapiens_hsa052110.67015773
63Prostate cancer_Homo sapiens_hsa052150.66586951
64Estrogen signaling pathway_Homo sapiens_hsa049150.65513588
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65222688
66Cocaine addiction_Homo sapiens_hsa050300.64941307
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64387562
68Sulfur metabolism_Homo sapiens_hsa009200.64201931
69N-Glycan biosynthesis_Homo sapiens_hsa005100.62052431
70Notch signaling pathway_Homo sapiens_hsa043300.61621065
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.61503041
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.60311007
73HTLV-I infection_Homo sapiens_hsa051660.59897888
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59262045
75Oxytocin signaling pathway_Homo sapiens_hsa049210.58642484
76Gastric acid secretion_Homo sapiens_hsa049710.58548291
77MAPK signaling pathway_Homo sapiens_hsa040100.58118085
78Apoptosis_Homo sapiens_hsa042100.57265735
79mTOR signaling pathway_Homo sapiens_hsa041500.56941944
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55727628
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55257333
82Calcium signaling pathway_Homo sapiens_hsa040200.55101222
83Caffeine metabolism_Homo sapiens_hsa002320.54948693
84AMPK signaling pathway_Homo sapiens_hsa041520.54737984
85Vibrio cholerae infection_Homo sapiens_hsa051100.53306633
86Salmonella infection_Homo sapiens_hsa051320.51505916
87Toxoplasmosis_Homo sapiens_hsa051450.50378059
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50302424
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50046697
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49888131
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49351999
92Endocytosis_Homo sapiens_hsa041440.49154077
93Pentose phosphate pathway_Homo sapiens_hsa000300.49049356
94Glutathione metabolism_Homo sapiens_hsa004800.48895746
95Insulin resistance_Homo sapiens_hsa049310.48859947
96Thyroid cancer_Homo sapiens_hsa052160.48607069
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.48166852
98Complement and coagulation cascades_Homo sapiens_hsa046100.47567189
99Ras signaling pathway_Homo sapiens_hsa040140.46709832
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.45171839
101Starch and sucrose metabolism_Homo sapiens_hsa005000.44856275
102Endometrial cancer_Homo sapiens_hsa052130.44750236
103Salivary secretion_Homo sapiens_hsa049700.43638090
104cAMP signaling pathway_Homo sapiens_hsa040240.42662013
105PPAR signaling pathway_Homo sapiens_hsa033200.41430426
106Prion diseases_Homo sapiens_hsa050200.40749424
107VEGF signaling pathway_Homo sapiens_hsa043700.39723654
108Galactose metabolism_Homo sapiens_hsa000520.38424993
109p53 signaling pathway_Homo sapiens_hsa041150.38062041
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37591566
111Acute myeloid leukemia_Homo sapiens_hsa052210.36987131
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35821474
113African trypanosomiasis_Homo sapiens_hsa051430.35283132
114Chemical carcinogenesis_Homo sapiens_hsa052040.35178742
115Bile secretion_Homo sapiens_hsa049760.34033847
116Mineral absorption_Homo sapiens_hsa049780.33882133
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33417453
118Renin-angiotensin system_Homo sapiens_hsa046140.33295544
119Hepatitis B_Homo sapiens_hsa051610.32358314

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