MRGPRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to histamine (GO:0034776)7.28240030
2opsonization (GO:0008228)6.84650570
3gamma-aminobutyric acid transport (GO:0015812)6.77543931
4cellular hyperosmotic response (GO:0071474)6.76260898
5detection of molecule of bacterial origin (GO:0032490)6.41248647
6regulation of complement activation (GO:0030449)6.27060294
7regulation of protein activation cascade (GO:2000257)5.77944317
8leukocyte migration involved in inflammatory response (GO:0002523)5.65832977
9regulation of macrophage chemotaxis (GO:0010758)5.34867400
10angiogenesis involved in wound healing (GO:0060055)5.31368097
11response to hydroperoxide (GO:0033194)5.28921810
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.28542448
13blood coagulation, intrinsic pathway (GO:0007597)5.22788638
14regulation of mononuclear cell migration (GO:0071675)5.06301626
15positive regulation of macrophage activation (GO:0043032)4.73161505
16hydrogen peroxide catabolic process (GO:0042744)4.48276177
17regulation of glucose import in response to insulin stimulus (GO:2001273)4.40017303
18cellular response to ammonium ion (GO:0071242)4.37381616
19macrophage activation involved in immune response (GO:0002281)4.30106695
20detection of external biotic stimulus (GO:0098581)4.28439038
21regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.26886287
22regulation of respiratory burst (GO:0060263)4.22880167
23response to copper ion (GO:0046688)4.20504639
24diol metabolic process (GO:0034311)4.12982082
25peripheral nervous system neuron development (GO:0048935)4.00054098
26sphingoid metabolic process (GO:0046519)3.94326065
27negative regulation of leukocyte chemotaxis (GO:0002689)3.92806259
28cell volume homeostasis (GO:0006884)3.92222163
29regulation of granulocyte chemotaxis (GO:0071622)3.86313323
30negative regulation of innate immune response (GO:0045824)3.78252059
31keratan sulfate catabolic process (GO:0042340)3.76550491
32regulation of humoral immune response (GO:0002920)3.66122439
33regulation of apoptotic cell clearance (GO:2000425)3.63709357
34cellular response to cadmium ion (GO:0071276)3.63024682
35positive regulation of cellular response to insulin stimulus (GO:1900078)3.59376858
36positive regulation of p38MAPK cascade (GO:1900745)3.51813657
37embryonic digestive tract development (GO:0048566)3.50711611
38negative regulation of blood vessel endothelial cell migration (GO:0043537)3.50692934
39detection of biotic stimulus (GO:0009595)3.48250175
40inner ear receptor cell development (GO:0060119)3.47820653
41positive regulation of nitric-oxide synthase activity (GO:0051000)3.37229315
42progesterone metabolic process (GO:0042448)3.36618931
43negative regulation of catenin import into nucleus (GO:0035414)3.30828729
44branching involved in salivary gland morphogenesis (GO:0060445)3.27777815
45cellular response to osmotic stress (GO:0071470)3.25280434
46cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.21405551
47regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.20557558
48macrophage activation (GO:0042116)3.13865429
49fibrinolysis (GO:0042730)3.10528264
50positive regulation of neutrophil migration (GO:1902624)3.08872478
51positive regulation of neutrophil chemotaxis (GO:0090023)3.08872478
52bone resorption (GO:0045453)3.04264940
53positive regulation of osteoblast proliferation (GO:0033690)3.04024952
54basement membrane organization (GO:0071711)3.03289933
55regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00210798
56negative regulation of BMP signaling pathway (GO:0030514)2.98144852
57estrogen biosynthetic process (GO:0006703)2.98124690
58positive regulation of toll-like receptor signaling pathway (GO:0034123)2.96119224
59positive regulation of granulocyte chemotaxis (GO:0071624)2.90476959
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90237519
61purine nucleotide salvage (GO:0032261)2.88552596
62protein kinase C signaling (GO:0070528)2.86869788
63C21-steroid hormone biosynthetic process (GO:0006700)2.85329016
64vitamin D metabolic process (GO:0042359)2.83120752
65regulation of neutrophil migration (GO:1902622)2.77035353
66regulation of neutrophil chemotaxis (GO:0090022)2.77035353
67protein activation cascade (GO:0072376)2.73607520
68positive regulation of hair follicle development (GO:0051798)2.72656905
69positive regulation of hair cycle (GO:0042635)2.72656905
70phosphatidylserine metabolic process (GO:0006658)2.68370973
71mitotic G1/S transition checkpoint (GO:0044819)2.67159061
72regulation of phospholipid biosynthetic process (GO:0071071)2.63400265
73platelet degranulation (GO:0002576)2.62425658
74regulation of chemokine-mediated signaling pathway (GO:0070099)2.61884883
75negative regulation of bone resorption (GO:0045779)2.60662253
76cGMP biosynthetic process (GO:0006182)2.60513587
77G-protein coupled receptor internalization (GO:0002031)2.59639493
78negative regulation of wound healing (GO:0061045)2.59328635
79regulation of positive chemotaxis (GO:0050926)2.59262841
80negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58465933
81response to antibiotic (GO:0046677)2.57527464
82sequestering of extracellular ligand from receptor (GO:0035581)2.57163009
83negative regulation of blood coagulation (GO:0030195)2.57147564
84negative regulation of hemostasis (GO:1900047)2.57147564
85negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57045433
86response to follicle-stimulating hormone (GO:0032354)2.56925241
87negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.55003497
88modulation of growth of symbiont involved in interaction with host (GO:0044144)2.55003497
89regulation of growth of symbiont in host (GO:0044126)2.55003497
90negative regulation of growth of symbiont in host (GO:0044130)2.55003497
91androgen biosynthetic process (GO:0006702)2.54736772
92mating behavior (GO:0007617)2.53452124
93phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52816343
94regulation of leukocyte chemotaxis (GO:0002688)2.50604993
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49323747
96ERK1 and ERK2 cascade (GO:0070371)2.48998966
97negative regulation of complement activation (GO:0045916)17.8248910
98negative regulation of protein activation cascade (GO:2000258)14.9638088
99negative regulation of humoral immune response (GO:0002921)12.3545855
100positive regulation of respiratory burst (GO:0060267)10.7178931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.25986924
2CDX2_19796622_ChIP-Seq_MESCs_Mouse3.52713069
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.38527241
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.27233129
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.20765635
6GATA1_22025678_ChIP-Seq_K562_Human2.40401188
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.32914590
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.27386904
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19229698
10CLOCK_20551151_ChIP-Seq_293T_Human2.16264121
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01821621
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99092756
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.95826108
14GATA2_21666600_ChIP-Seq_HMVEC_Human1.85538164
15HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.82089069
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80328904
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77165127
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73436574
19AR_21572438_ChIP-Seq_LNCaP_Human1.72618163
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71885096
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.69353542
22SOX2_20726797_ChIP-Seq_SW620_Human1.65759529
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61665932
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.60513527
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57490038
26* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55013316
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51136242
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48860053
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48510623
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45480637
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44849788
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44172169
33DROSHA_22980978_ChIP-Seq_HELA_Human1.42943049
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41002701
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41002701
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.38241317
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.37784039
38* RXR_22158963_ChIP-Seq_LIVER_Mouse1.37628862
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37619746
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36936760
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36198521
42BCAT_22108803_ChIP-Seq_LS180_Human1.35051904
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33542252
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33542252
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32819800
46ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31189210
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30881256
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30688171
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29362945
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26547030
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.26311866
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25051016
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.24909895
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24583219
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23920711
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23745333
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.23635333
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21286870
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20976483
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20564701
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20099021
62CJUN_26792858_Chip-Seq_BT549_Human1.18738769
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17740025
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16350205
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14579506
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14000578
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13437771
68RACK7_27058665_Chip-Seq_MCF-7_Human1.12434710
69GATA1_19941826_ChIP-Seq_K562_Human1.11763353
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.11510713
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11482788
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11482788
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10490254
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.09591987
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09280748
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09165494
77KDM2B_26808549_Chip-Seq_K562_Human1.06854544
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03074917
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02628892
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01818437
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00716111
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00152807
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98655949
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98406802
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98371551
86CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98090896
87EGR1_19032775_ChIP-ChIP_M12_Human0.96069695
88TBX20_22080862_ChIP-Seq_HEART_Mouse0.94949291
89TBX20_22328084_ChIP-Seq_HEART_Mouse0.94949291
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94287740
91AHR_22903824_ChIP-Seq_MCF-7_Human0.93131516
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91976088
93LXR_22292898_ChIP-Seq_THP-1_Human0.89242606
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89236166
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88773099
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.88122226
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88092659
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86174720
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85514558
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85242201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.72915443
2MP0002837_dystrophic_cardiac_calcinosis5.68503656
3MP0001542_abnormal_bone_strength4.74696867
4MP0000604_amyloidosis3.38185427
5MP0006054_spinal_hemorrhage3.34875243
6MP0002254_reproductive_system_inflammat3.29794671
7MP0010234_abnormal_vibrissa_follicle3.01928322
8MP0004084_abnormal_cardiac_muscle2.81960289
9MP0001879_abnormal_lymphatic_vessel2.76958959
10MP0002998_abnormal_bone_remodeling2.60475885
11MP0003567_abnormal_fetal_cardiomyocyte2.53372140
12MP0003279_aneurysm2.45244274
13MP0001958_emphysema2.20119327
14MP0002877_abnormal_melanocyte_morpholog2.09001514
15MP0005164_abnormal_response_to2.06908371
16MP0003705_abnormal_hypodermis_morpholog2.05733218
17MP0005623_abnormal_meninges_morphology2.04493783
18MP0004885_abnormal_endolymph2.02890101
19MP0000681_abnormal_thyroid_gland2.01765484
20MP0003172_abnormal_lysosome_physiology2.01291091
21MP0004036_abnormal_muscle_relaxation1.97495995
22MP0004510_myositis1.78822579
23MP0000767_abnormal_smooth_muscle1.77727466
24MP0005503_abnormal_tendon_morphology1.77074128
25MP0005275_abnormal_skin_tensile1.74235667
26MP0004272_abnormal_basement_membrane1.73737478
27MP0003950_abnormal_plasma_membrane1.72813911
28MP0004858_abnormal_nervous_system1.69201064
29MP0000749_muscle_degeneration1.68408801
30MP0010368_abnormal_lymphatic_system1.66289139
31MP0002909_abnormal_adrenal_gland1.60641824
32MP0004883_abnormal_blood_vessel1.56093114
33MP0005058_abnormal_lysosome_morphology1.53529657
34MP0008775_abnormal_heart_ventricle1.51130985
35MP0005171_absent_coat_pigmentation1.47469396
36MP0006138_congestive_heart_failure1.46652593
37MP0003566_abnormal_cell_adhesion1.33670533
38MP0002269_muscular_atrophy1.33472349
39MP0003136_yellow_coat_color1.28733842
40MP0005377_hearing/vestibular/ear_phenot1.25991932
41MP0003878_abnormal_ear_physiology1.25991932
42MP0005508_abnormal_skeleton_morphology1.23209106
43MP0000685_abnormal_immune_system1.22312263
44MP0000163_abnormal_cartilage_morphology1.19729481
45MP0002796_impaired_skin_barrier1.19682302
46MP0000249_abnormal_blood_vessel1.19417291
47MP0003191_abnormal_cellular_cholesterol1.19019219
48MP0003091_abnormal_cell_migration1.18273221
49MP0009840_abnormal_foam_cell1.16538623
50MP0000858_altered_metastatic_potential1.14768321
51MP0001849_ear_inflammation1.07488968
52MP0005023_abnormal_wound_healing1.07216824
53MP0000049_abnormal_middle_ear1.06536781
54MP0002896_abnormal_bone_mineralization1.06319538
55MP0010329_abnormal_lipoprotein_level1.04565128
56MP0002115_abnormal_skeleton_extremities1.01534181
57MP0000343_altered_response_to1.01351824
58MP0002060_abnormal_skin_morphology1.00847375
59MP0010678_abnormal_skin_adnexa1.00328494
60MP0009053_abnormal_anal_canal0.98074524
61MP0004484_altered_response_of0.97840817
62MP0001533_abnormal_skeleton_physiology0.95175544
63MP0005085_abnormal_gallbladder_physiolo0.92507523
64MP0005166_decreased_susceptibility_to0.89643916
65MP0000639_abnormal_adrenal_gland0.88873007
66MP0004147_increased_porphyrin_level0.88013879
67MP0003385_abnormal_body_wall0.87704443
68MP0001915_intracranial_hemorrhage0.85015857
69MP0002419_abnormal_innate_immunity0.84425483
70MP0003303_peritoneal_inflammation0.81381191
71MP0001188_hyperpigmentation0.80877281
72MP0003690_abnormal_glial_cell0.77223773
73MP0003252_abnormal_bile_duct0.76760778
74MP0005084_abnormal_gallbladder_morpholo0.76464122
75MP0005670_abnormal_white_adipose0.76180890
76MP0003453_abnormal_keratinocyte_physiol0.74956200
77MP0001299_abnormal_eye_distance/0.74018278
78MP0003795_abnormal_bone_structure0.73929068
79MP0001614_abnormal_blood_vessel0.73843916
80MP0005174_abnormal_tail_pigmentation0.73391889
81MP0010630_abnormal_cardiac_muscle0.71419337
82MP0002090_abnormal_vision0.69835855
83MP0002113_abnormal_skeleton_development0.67879258
84MP0003941_abnormal_skin_development0.67570905
85MP0005636_abnormal_mineral_homeostasis0.66640965
86MP0000538_abnormal_urinary_bladder0.64232802
87MP0005390_skeleton_phenotype0.61171732
88MP0009785_altered_susceptibility_to0.60922700
89MP0001544_abnormal_cardiovascular_syste0.60311445
90MP0005385_cardiovascular_system_phenoty0.60311445
91MP0005165_increased_susceptibility_to0.59368741
92MP0003448_altered_tumor_morphology0.59344438
93MP0002128_abnormal_blood_circulation0.59238205
94MP0002177_abnormal_outer_ear0.55565532
95MP0004215_abnormal_myocardial_fiber0.54059372
96MP0002925_abnormal_cardiovascular_devel0.53167422
97MP0005248_abnormal_Harderian_gland0.51012235
98MP0001243_abnormal_dermal_layer0.50657700
99MP0000920_abnormal_myelination0.50275214
100MP0002133_abnormal_respiratory_system0.47030739

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)7.74698878
2Systemic lupus erythematosus (HP:0002725)7.66953481
3Spondylolisthesis (HP:0003302)7.58911123
4Osteolytic defects of the hand bones (HP:0009699)6.13086199
5Osteolytic defects of the phalanges of the hand (HP:0009771)6.13086199
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)6.04467986
7Persistence of primary teeth (HP:0006335)5.80930805
8Delayed closure of the anterior fontanelle (HP:0001476)5.45420755
9Right ventricular cardiomyopathy (HP:0011663)5.01056421
10Hyporeflexia of lower limbs (HP:0002600)4.91209495
11Premature rupture of membranes (HP:0001788)4.89352477
12Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.78622837
13Abnormality of the frontal sinuses (HP:0002687)4.74949584
14Limb-girdle muscle atrophy (HP:0003797)4.64171749
15Abnormality of proline metabolism (HP:0010907)4.55812700
16Hydroxyprolinuria (HP:0003080)4.55812700
17Broad metatarsal (HP:0001783)4.30818435
18Purpura (HP:0000979)4.04169278
19Abnormal hemoglobin (HP:0011902)4.01261725
20Cervical subluxation (HP:0003308)3.96616724
21Ridged nail (HP:0001807)3.47033839
22Distal lower limb muscle weakness (HP:0009053)3.31748000
23Wormian bones (HP:0002645)3.26121957
24Delayed cranial suture closure (HP:0000270)3.17810283
25Mucopolysacchariduria (HP:0008155)2.92583774
26Urinary glycosaminoglycan excretion (HP:0003541)2.92583774
27Ulnar deviation of the wrist (HP:0003049)2.87958670
28Sex reversal (HP:0012245)2.86993377
29Abnormal sex determination (HP:0012244)2.86993377
30Blue sclerae (HP:0000592)2.83569679
31Shallow orbits (HP:0000586)2.78895368
32Bulbar palsy (HP:0001283)2.78733865
33Redundant skin (HP:0001582)2.77381451
34Turricephaly (HP:0000262)2.76433139
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75961264
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75961264
37Abnormality of polysaccharide metabolism (HP:0011012)2.75961264
38EMG: myopathic abnormalities (HP:0003458)2.73879926
39Synostosis involving the elbow (HP:0003938)2.63896823
40Humeroradial synostosis (HP:0003041)2.63896823
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61337630
42Gingival bleeding (HP:0000225)2.53394118
43Ovoid vertebral bodies (HP:0003300)2.52328957
44Coronal craniosynostosis (HP:0004440)2.51806210
45Enlarged penis (HP:0000040)2.48627996
46Short hallux (HP:0010109)2.40287146
47Neck muscle weakness (HP:0000467)2.37178986
48Abnormality of the calf musculature (HP:0001430)2.33400594
49Vacuolated lymphocytes (HP:0001922)2.27162233
50Distal lower limb amyotrophy (HP:0008944)2.26556978
51Axonal loss (HP:0003447)2.21280212
52Aplasia/Hypoplasia of the hallux (HP:0008362)2.18310860
53Osteomyelitis (HP:0002754)2.15799508
54Dysostosis multiplex (HP:0000943)2.11387920
55Narrow palate (HP:0000189)2.09347746
56Foot dorsiflexor weakness (HP:0009027)2.08362470
57Abnormality of molar (HP:0011077)2.07852151
58Abnormality of molar morphology (HP:0011070)2.07852151
59Deep venous thrombosis (HP:0002625)2.07804255
60Lower limb amyotrophy (HP:0007210)2.07605900
61Abnormality of primary teeth (HP:0006481)2.06760889
62Elbow flexion contracture (HP:0002987)2.04456042
63Aplastic anemia (HP:0001915)2.01673458
64Hyperaldosteronism (HP:0000859)1.97556318
65Renal salt wasting (HP:0000127)1.96942811
66Abnormality of macrophages (HP:0004311)1.96725469
67Palpebral edema (HP:0100540)1.94737000
68Ulnar bowing (HP:0003031)1.93200030
69Hyperextensible skin (HP:0000974)1.92799327
70Abnormality of liposaccharide metabolism (HP:0010968)1.92305483
71Abnormality of glycosphingolipid metabolism (HP:0004343)1.92305483
72Abnormality of glycolipid metabolism (HP:0010969)1.92305483
73Conjugated hyperbilirubinemia (HP:0002908)1.91369417
74Thickened calvaria (HP:0002684)1.89859773
75Aqueductal stenosis (HP:0002410)1.89855985
76Scapular winging (HP:0003691)1.88921569
77Abnormality of the foot musculature (HP:0001436)1.87596205
78Erythema (HP:0010783)1.87422253
79Eczematoid dermatitis (HP:0000976)1.79828315
80Fragile skin (HP:0001030)1.78798273
81Bone pain (HP:0002653)1.78272990
82Abnormal delivery (HP:0001787)1.78091864
83Hyperphosphatemia (HP:0002905)1.74056810
84Petechiae (HP:0000967)1.73597950
85Bronchomalacia (HP:0002780)1.72031965
86Asymmetric septal hypertrophy (HP:0001670)1.70626236
87Increased purine levels (HP:0004368)1.69925977
88Hyperuricemia (HP:0002149)1.69925977
89Wide anterior fontanel (HP:0000260)1.65990304
90Septo-optic dysplasia (HP:0100842)1.65205970
91Scanning speech (HP:0002168)1.65185875
92Cerebral aneurysm (HP:0004944)1.64479477
93Distal upper limb amyotrophy (HP:0007149)1.64106662
94Upper limb amyotrophy (HP:0009129)1.64106662
95Bowed forearm bones (HP:0003956)1.63964628
96Bowing of the arm (HP:0006488)1.63964628
97Ankle contracture (HP:0006466)1.63697617
98Autoamputation (HP:0001218)1.61386198
99Radial bowing (HP:0002986)1.60987211
100Soft skin (HP:0000977)1.57618440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.44873089
2EPHB23.92540320
3TRPM73.28863116
4BRAF3.22534395
5BMX2.86257157
6PDK22.72630526
7MAP3K142.67602304
8PAK42.46065489
9LIMK12.44169727
10ERBB32.20943518
11MAP2K22.03747009
12MAPK121.99617601
13LATS21.96514280
14ROCK21.95982939
15TSSK61.94995442
16MARK31.94713636
17TGFBR21.94419485
18PDGFRA1.70637906
19EPHA31.63260734
20EPHB11.62715973
21FGFR11.62440372
22MAPKAPK51.60110530
23FGFR21.54983236
24PDPK11.49460706
25TESK11.49069718
26ARAF1.47365704
27NME21.46814412
28AKT31.45682438
29ROCK11.34921096
30FGFR41.31644640
31MAPK71.31551845
32MAP3K71.20736091
33MYLK1.18089277
34MAP3K31.15521296
35MAP2K31.14109596
36SCYL21.11189957
37KIT1.05354822
38TYRO31.04809583
39PTK61.03152778
40CLK10.98671757
41TYK20.98406965
42TRIB30.95760242
43CSNK1A1L0.95399012
44ABL20.91600793
45TTN0.87518031
46MAP2K10.86706781
47MST1R0.86257198
48EPHA20.80277283
49PKN20.80113743
50PDK10.79523829
51NME10.78746017
52DDR20.74007791
53MAP3K130.72834083
54PTK2B0.71980220
55FGFR30.71529753
56JAK10.71524636
57TIE10.70722029
58TBK10.69903479
59NEK60.69429629
60FER0.69014215
61RPS6KA40.64963074
62WNK10.63439034
63IGF1R0.62910196
64PIM20.58446571
65NTRK30.58396439
66CSNK1G30.57737488
67PTK20.57567929
68PRKCE0.57105542
69CSNK1G20.56799385
70MAP3K80.54454379
71NEK90.54099973
72MATK0.53349172
73STK380.51186691
74CSNK1G10.50926001
75DMPK0.50683009
76PHKG20.48903009
77PHKG10.48903009
78MAP3K90.48663513
79IKBKE0.46114675
80PRKD10.42315997
81RPS6KA50.41016464
82INSR0.39818864
83ZAP700.39554164
84HCK0.39435521
85MTOR0.39183251
86LRRK20.35645843
87AKT20.33459360
88MAP3K10.33424252
89PRKACB0.32959628
90PIK3CG0.31872517
91BMPR20.31594506
92KSR20.30045228
93ITK0.29977540
94NTRK10.29711302
95STK240.29663487
96MAPK40.28259098
97PDGFRB0.28158906
98KDR0.28152960
99SIK20.28090832
100SRC0.27694760

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005315.02006213
2Histidine metabolism_Homo sapiens_hsa003404.57992256
3Complement and coagulation cascades_Homo sapiens_hsa046103.17515864
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.06628704
5Tryptophan metabolism_Homo sapiens_hsa003802.66987844
6Lysosome_Homo sapiens_hsa041422.62030836
7Sphingolipid metabolism_Homo sapiens_hsa006002.50738800
8Arachidonic acid metabolism_Homo sapiens_hsa005902.39146361
9Arginine and proline metabolism_Homo sapiens_hsa003302.33720600
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24526974
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97212590
12Linoleic acid metabolism_Homo sapiens_hsa005911.94153750
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.82922014
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80272596
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74878735
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70587364
17Dilated cardiomyopathy_Homo sapiens_hsa054141.68752044
18Prion diseases_Homo sapiens_hsa050201.68029867
19Glutathione metabolism_Homo sapiens_hsa004801.64227265
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52185089
21ECM-receptor interaction_Homo sapiens_hsa045121.42351506
22Staphylococcus aureus infection_Homo sapiens_hsa051501.38808806
23Osteoclast differentiation_Homo sapiens_hsa043801.38178854
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30903404
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.29549200
26Rheumatoid arthritis_Homo sapiens_hsa053231.27614734
27Ras signaling pathway_Homo sapiens_hsa040141.14806955
28Pertussis_Homo sapiens_hsa051331.11829802
29Apoptosis_Homo sapiens_hsa042101.06539526
30Fat digestion and absorption_Homo sapiens_hsa049751.02969130
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02300551
32Thyroid hormone synthesis_Homo sapiens_hsa049181.01036407
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00884568
34Phagosome_Homo sapiens_hsa041451.00658090
35Proteoglycans in cancer_Homo sapiens_hsa052051.00375635
36Amoebiasis_Homo sapiens_hsa051461.00352720
37Other glycan degradation_Homo sapiens_hsa005110.99379185
38Caffeine metabolism_Homo sapiens_hsa002320.95005953
39Hematopoietic cell lineage_Homo sapiens_hsa046400.93088464
40Nitrogen metabolism_Homo sapiens_hsa009100.87963137
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87750898
42Ovarian steroidogenesis_Homo sapiens_hsa049130.84035989
43Ether lipid metabolism_Homo sapiens_hsa005650.82994511
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82195847
45Pentose phosphate pathway_Homo sapiens_hsa000300.82003767
46Focal adhesion_Homo sapiens_hsa045100.81881360
47Vibrio cholerae infection_Homo sapiens_hsa051100.81066384
48Tuberculosis_Homo sapiens_hsa051520.79354038
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76339885
50Galactose metabolism_Homo sapiens_hsa000520.75542818
51Gap junction_Homo sapiens_hsa045400.72409561
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72083220
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.71892743
54Starch and sucrose metabolism_Homo sapiens_hsa005000.68628478
55HIF-1 signaling pathway_Homo sapiens_hsa040660.65417049
56Thyroid cancer_Homo sapiens_hsa052160.65031639
57Rap1 signaling pathway_Homo sapiens_hsa040150.65018081
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.59840732
59Prostate cancer_Homo sapiens_hsa052150.58306422
60Melanogenesis_Homo sapiens_hsa049160.54915503
61Acute myeloid leukemia_Homo sapiens_hsa052210.54579408
62Salmonella infection_Homo sapiens_hsa051320.54292524
63Fatty acid elongation_Homo sapiens_hsa000620.53123862
64MAPK signaling pathway_Homo sapiens_hsa040100.51415421
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50920795
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50639849
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50590738
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50372679
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49492148
70PPAR signaling pathway_Homo sapiens_hsa033200.48398955
71Chronic myeloid leukemia_Homo sapiens_hsa052200.47220978
72Antigen processing and presentation_Homo sapiens_hsa046120.47120916
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45422402
74Renal cell carcinoma_Homo sapiens_hsa052110.43205525
75Adherens junction_Homo sapiens_hsa045200.39951132
76TGF-beta signaling pathway_Homo sapiens_hsa043500.39790816
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39716753
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.37792033
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.36837560
80FoxO signaling pathway_Homo sapiens_hsa040680.36540038
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36364559
82Melanoma_Homo sapiens_hsa052180.35849854
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.33497954
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31919686
85Synaptic vesicle cycle_Homo sapiens_hsa047210.31418055
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29748045
87VEGF signaling pathway_Homo sapiens_hsa043700.29418688
88Cocaine addiction_Homo sapiens_hsa050300.27454222
89Serotonergic synapse_Homo sapiens_hsa047260.27029192
90Chemical carcinogenesis_Homo sapiens_hsa052040.24522978
91Dorso-ventral axis formation_Homo sapiens_hsa043200.22249334
92TNF signaling pathway_Homo sapiens_hsa046680.20484297
93Shigellosis_Homo sapiens_hsa051310.19284982
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19179608
95Hepatitis B_Homo sapiens_hsa051610.18762700
96Toxoplasmosis_Homo sapiens_hsa051450.18127514
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17543596
98Collecting duct acid secretion_Homo sapiens_hsa049660.17417912
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17416579
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17265472

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