MRGPRX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.56701181
2detection of temperature stimulus involved in sensory perception (GO:0050961)7.56701181
3detection of temperature stimulus (GO:0016048)7.10353305
4positive regulation of cell size (GO:0045793)6.78554346
5positive regulation of meiotic cell cycle (GO:0051446)6.49451819
6syncytium formation (GO:0006949)6.39425809
7basic amino acid transport (GO:0015802)6.22160127
8L-alpha-amino acid transmembrane transport (GO:1902475)5.94378351
9regulation of cellular respiration (GO:0043457)5.89915228
10neuronal action potential (GO:0019228)5.88599745
11peripheral nervous system neuron development (GO:0048935)5.87625480
12positive regulation of oligodendrocyte differentiation (GO:0048714)5.78466672
13negative regulation of meiotic cell cycle (GO:0051447)5.53867112
14regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.49174185
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.44042964
16mitotic G1 DNA damage checkpoint (GO:0031571)5.29376781
17neurofilament cytoskeleton organization (GO:0060052)5.22177951
18cell migration in hindbrain (GO:0021535)5.15856075
19mitotic G1/S transition checkpoint (GO:0044819)5.12313357
20negative regulation of calcium ion transport into cytosol (GO:0010523)5.10942009
21potassium ion export (GO:0071435)5.07778927
22heme transport (GO:0015886)5.03979462
23proline transport (GO:0015824)5.00683888
24G1 DNA damage checkpoint (GO:0044783)4.88691469
25negative regulation of dendrite morphogenesis (GO:0050774)4.82842072
26positive regulation of megakaryocyte differentiation (GO:0045654)4.82697182
27negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.62554384
28estrogen biosynthetic process (GO:0006703)4.56663638
29behavioral response to pain (GO:0048266)4.55566777
30membrane depolarization during action potential (GO:0086010)4.51185210
31negative regulation of macrophage differentiation (GO:0045650)4.50471974
32branching involved in labyrinthine layer morphogenesis (GO:0060670)4.45956614
33regulation of mitochondrial translation (GO:0070129)4.41461071
34ribosomal small subunit assembly (GO:0000028)4.38836071
35nucleoside transmembrane transport (GO:1901642)4.34099908
36neuronal action potential propagation (GO:0019227)4.28995923
37nucleoside transport (GO:0015858)4.24097897
38DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.23964294
39chaperone-mediated protein transport (GO:0072321)4.18310333
40response to water (GO:0009415)4.13372857
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.12704602
42positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.11246869
43placenta development (GO:0001890)4.10589959
44ribosomal small subunit biogenesis (GO:0042274)4.07064065
45negative regulation of JUN kinase activity (GO:0043508)4.06701956
46cellular response to ATP (GO:0071318)4.04397098
47adenosine metabolic process (GO:0046085)4.04006212
48DNA replication initiation (GO:0006270)4.00961900
49pseudouridine synthesis (GO:0001522)3.94765900
50retinal ganglion cell axon guidance (GO:0031290)3.93323759
51keratinocyte development (GO:0003334)3.92857403
52DNA damage response, signal transduction resulting in transcription (GO:0042772)3.91129111
53regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.90760523
54regulation of gene expression by genetic imprinting (GO:0006349)3.89143276
55response to pain (GO:0048265)3.87198497
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.83281534
57negative regulation of complement activation (GO:0045916)3.80224415
58viral transcription (GO:0019083)3.80159781
59negative regulation of homotypic cell-cell adhesion (GO:0034111)3.78267548
60positive regulation of muscle hypertrophy (GO:0014742)3.77205598
61positive regulation of cardiac muscle hypertrophy (GO:0010613)3.77205598
62glycine transport (GO:0015816)3.76472196
63translational termination (GO:0006415)3.74594083
64neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.74316045
65rRNA modification (GO:0000154)3.72985471
66embryonic placenta development (GO:0001892)3.72370418
67phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.71894344
68histamine secretion (GO:0001821)3.71346025
69positive regulation of hair follicle development (GO:0051798)3.70744352
70positive regulation of hair cycle (GO:0042635)3.70744352
71deoxyribose phosphate biosynthetic process (GO:0046385)3.69608163
722-deoxyribonucleotide biosynthetic process (GO:0009265)3.69608163
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68893671
74regulation of platelet aggregation (GO:0090330)3.65604245
75cell communication involved in cardiac conduction (GO:0086065)3.63972048
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.63754494
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.61387810
78ribosome biogenesis (GO:0042254)3.61107519
79formation of translation preinitiation complex (GO:0001731)3.58088562
80iron coordination entity transport (GO:1901678)3.57714393
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.56436886
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.54529835
83ATP hydrolysis coupled proton transport (GO:0015991)3.54529835
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53227775
85urogenital system development (GO:0001655)3.51772456
86peptidyl-tyrosine autophosphorylation (GO:0038083)3.50816056
87polyamine biosynthetic process (GO:0006596)3.49550350
88ribonucleoprotein complex biogenesis (GO:0022613)3.49196149
89positive regulation of Cdc42 GTPase activity (GO:0043089)3.47707767
90synaptic vesicle maturation (GO:0016188)3.47457727
91pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.45009458
92UMP biosynthetic process (GO:0006222)3.45009458
93pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.45009458
94UMP metabolic process (GO:0046049)3.45009458
95urea cycle (GO:0000050)3.43546858
96tolerance induction (GO:0002507)3.43461414
97membrane repolarization (GO:0086009)3.42588866
98urinary tract smooth muscle contraction (GO:0014848)3.38998976
99sphingomyelin metabolic process (GO:0006684)3.38623037
100embryonic process involved in female pregnancy (GO:0060136)3.38016501
101translational initiation (GO:0006413)3.34985760
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.34603378
103termination of RNA polymerase III transcription (GO:0006386)3.34333473
104transcription elongation from RNA polymerase III promoter (GO:0006385)3.34333473
105regulation of oxidative phosphorylation (GO:0002082)3.34100956
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32218258
107hippo signaling (GO:0035329)3.30989830
108positive regulation of amino acid transport (GO:0051957)3.30764556
109establishment of epithelial cell polarity (GO:0090162)3.30577594
110action potential (GO:0001508)3.29288292
111positive regulation of signal transduction by p53 class mediator (GO:1901798)3.28592021
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26566970
113alanine transport (GO:0032328)3.26406088
114enteric nervous system development (GO:0048484)3.25849122
115response to ATP (GO:0033198)3.25277863
116sprouting angiogenesis (GO:0002040)3.24767721
117N-terminal protein amino acid modification (GO:0031365)3.24514007
118translational elongation (GO:0006414)3.23689992
119regulation of phosphatidylinositol 3-kinase activity (GO:0043551)3.21642022
120cranial nerve development (GO:0021545)3.21268795
121viral life cycle (GO:0019058)3.21091596
122negative regulation of protein activation cascade (GO:2000258)3.19822605
123regulation of sensory perception of pain (GO:0051930)3.18170890
124regulation of sensory perception (GO:0051931)3.18170890
125protein localization to synapse (GO:0035418)3.17137501
126negative regulation of dendrite development (GO:2000171)3.16561740
127cofactor transport (GO:0051181)3.15577425
128nucleotide salvage (GO:0043173)3.15560067
129rRNA methylation (GO:0031167)3.14994912
130axon cargo transport (GO:0008088)3.14530827
131digestive tract morphogenesis (GO:0048546)3.13003767
132female genitalia development (GO:0030540)3.12442105
133regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10963745
134translation (GO:0006412)3.10890168
135glutamate secretion (GO:0014047)3.09905652
136detection of mechanical stimulus involved in sensory perception (GO:0050974)3.09758117
137positive regulation of potassium ion transmembrane transport (GO:1901381)3.08001222
138maturation of SSU-rRNA (GO:0030490)3.06379231
139urea metabolic process (GO:0019627)3.06299077
140regulation of histone phosphorylation (GO:0033127)3.05444998
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05335096
142negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.04865747
143negative regulation of macroautophagy (GO:0016242)3.03598107
144SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03237546
145sodium ion transmembrane transport (GO:0035725)3.01562981
146regulation of odontogenesis (GO:0042481)3.00902958
147pyrimidine-containing compound transmembrane transport (GO:0072531)2.99647858
148peptidyl-threonine dephosphorylation (GO:0035970)2.99636052
149genetic imprinting (GO:0071514)2.99048246
150CDP-diacylglycerol metabolic process (GO:0046341)2.98790124
151layer formation in cerebral cortex (GO:0021819)2.98182572
152negative regulation of Notch signaling pathway (GO:0045746)2.95566985
153vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94514128
154protein targeting to mitochondrion (GO:0006626)2.94051922
155ribosomal large subunit biogenesis (GO:0042273)2.93563669
156ncRNA 3-end processing (GO:0043628)2.92412088
157cotranslational protein targeting to membrane (GO:0006613)2.92331549
158pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.91104470
159protein targeting to ER (GO:0045047)2.90668593
160sensory perception of pain (GO:0019233)2.89740051
161membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.89697483
162cellular protein complex disassembly (GO:0043624)2.87993088
163innervation (GO:0060384)2.87566935
164regulation of early endosome to late endosome transport (GO:2000641)2.85684788
165dopamine receptor signaling pathway (GO:0007212)2.85547900
166plasma membrane repair (GO:0001778)2.84777383
167response to xenobiotic stimulus (GO:0009410)2.84309536
168cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80987443
169microtubule polymerization or depolymerization (GO:0031109)2.79513662
170regulation of synaptic vesicle exocytosis (GO:2000300)2.79296475
171regulation of amyloid precursor protein catabolic process (GO:1902991)2.78902685
172regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.75939927
173positive regulation of potassium ion transport (GO:0043268)2.74750934
174deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.73936076
175neuron fate specification (GO:0048665)2.73080669
176organelle transport along microtubule (GO:0072384)2.72413566
177regulation of homotypic cell-cell adhesion (GO:0034110)2.69817238
178glycosphingolipid biosynthetic process (GO:0006688)2.69795124
179regulation of potassium ion transmembrane transporter activity (GO:1901016)2.68960436
180cerebellar Purkinje cell differentiation (GO:0021702)2.67555437
181regulation of collateral sprouting (GO:0048670)2.67270891
182negative regulation of humoral immune response (GO:0002921)2.66841595
183negative regulation of microtubule polymerization (GO:0031115)2.66004204
184regulation of membrane repolarization (GO:0060306)2.62919477
185membrane depolarization (GO:0051899)2.62003437
186nerve growth factor signaling pathway (GO:0038180)2.61425598
187regulation of dopamine secretion (GO:0014059)2.60213732
188establishment of mitochondrion localization (GO:0051654)2.59959038
189regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59059913
190regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56860964
191negative regulation of cation channel activity (GO:2001258)2.56784435
192vesicle transport along microtubule (GO:0047496)2.56171604
193membrane repolarization during action potential (GO:0086011)2.53815714
194synaptic vesicle exocytosis (GO:0016079)2.51876353
195calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51407557
196protein polyglutamylation (GO:0018095)2.49369194
197negative regulation of heart rate (GO:0010459)2.48490915
198neuron cell-cell adhesion (GO:0007158)2.47034865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.60398840
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.50571319
3GATA1_26923725_Chip-Seq_HPCs_Mouse3.48691190
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34925483
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23462313
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21398566
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08902861
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05819864
9EZH2_22144423_ChIP-Seq_EOC_Human2.97700634
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.92052309
11SCL_19346495_ChIP-Seq_HPC-7_Human2.87172298
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79238271
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70926544
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.65914930
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65491101
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63714757
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58855885
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50396597
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37009163
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32546918
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32428454
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30664210
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29053987
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25236651
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.25016729
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.20966970
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19416276
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18981611
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15505399
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11884075
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11884075
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.11219205
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.05304603
34DCP1A_22483619_ChIP-Seq_HELA_Human1.98643985
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97311413
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.96439693
37XRN2_22483619_ChIP-Seq_HELA_Human1.95623403
38BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.94880701
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92419839
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92404499
41REST_21632747_ChIP-Seq_MESCs_Mouse1.89275485
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88240195
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84979860
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84265747
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79369244
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79005313
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78897408
48GBX2_23144817_ChIP-Seq_PC3_Human1.78327077
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78032930
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.73860695
51GABP_19822575_ChIP-Seq_HepG2_Human1.73003218
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72976188
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72010282
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68834980
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66738003
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.66622020
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.65433531
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.63961703
59VDR_22108803_ChIP-Seq_LS180_Human1.61099640
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.59814883
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.59737841
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57607088
63EGR1_19032775_ChIP-ChIP_M12_Human1.57366616
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57315164
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.53599448
66AHR_22903824_ChIP-Seq_MCF-7_Human1.51637739
67TTF2_22483619_ChIP-Seq_HELA_Human1.50353579
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47928483
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.47618104
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47323713
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.46208125
72* CTCF_27219007_Chip-Seq_Bcells_Human1.44673075
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44228928
74AR_21909140_ChIP-Seq_LNCAP_Human1.41959071
75ZNF263_19887448_ChIP-Seq_K562_Human1.41383191
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41234400
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38382556
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38349954
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37267575
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.37248449
81SMAD4_21799915_ChIP-Seq_A2780_Human1.35883194
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34772271
83TAF15_26573619_Chip-Seq_HEK293_Human1.32987090
84KDM2B_26808549_Chip-Seq_K562_Human1.31611901
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30446919
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29727031
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29688375
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29303870
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28665449
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27284035
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27074283
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.26884274
93VDR_21846776_ChIP-Seq_THP-1_Human1.26457506
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26160002
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25789584
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25789584
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25789584
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25237516
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25204414
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24842631
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.24368444
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23006902
103KDM5A_27292631_Chip-Seq_BREAST_Human1.21680350
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21290495
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21067811
106DROSHA_22980978_ChIP-Seq_HELA_Human1.21025564
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20562974
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20263425
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.20054030
110RACK7_27058665_Chip-Seq_MCF-7_Human1.20025559
111P300_19829295_ChIP-Seq_ESCs_Human1.19738878
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18818547
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18042883
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17608550
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.17042442
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16447404
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.15802928
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14847953
119FOXP3_21729870_ChIP-Seq_TREG_Human1.14839656
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14596915
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13858789
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13640328
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13382587
124BCAT_22108803_ChIP-Seq_LS180_Human1.12978280
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12460107
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11699335
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11577216
128* SMAD4_21741376_ChIP-Seq_HESCs_Human1.10637982
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.09679839
130VDR_23849224_ChIP-Seq_CD4+_Human1.09570318
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07832802
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06639389
133KDM2B_26808549_Chip-Seq_REH_Human1.05693090
134TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05218309
135KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03827772
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03404974
137NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03346725
138SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03065886
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.02355199
140HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02206927
141CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01910551
142TFEB_21752829_ChIP-Seq_HELA_Human1.01808619
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01384963
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99035150
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97624313
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97601132
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.97513048
148* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97140262
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97127957
150RING1B_27294783_Chip-Seq_ESCs_Mouse0.96461942
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.96235318
152AR_25329375_ChIP-Seq_VCAP_Human0.95828235
153LXR_22292898_ChIP-Seq_THP-1_Human0.95548523
154HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95383501
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.94721789
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94626457
157CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94584292
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94409690
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94322940
160SOX2_19829295_ChIP-Seq_ESCs_Human0.94314549
161NANOG_19829295_ChIP-Seq_ESCs_Human0.94314549
162FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93959722
163STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92913578
164PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92254148
165ZNF274_21170338_ChIP-Seq_K562_Hela0.92082012
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91856552
167ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91628465
168FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90911794
169* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90762513
170TET1_21490601_ChIP-Seq_MESCs_Mouse0.90705050
171TP53_20018659_ChIP-ChIP_R1E_Mouse0.90640553
172TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90570749
173NOTCH1_21737748_ChIP-Seq_TLL_Human0.90426164
174SOX2_20726797_ChIP-Seq_SW620_Human0.87808870
175STAT3_23295773_ChIP-Seq_U87_Human0.87710682
176NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86718908
177NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86718908
178WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86174542
179SMAD3_21741376_ChIP-Seq_ESCs_Human0.86118323
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86001312
181SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85779556
182ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85145390
183ARNT_22903824_ChIP-Seq_MCF-7_Human0.85053232
184THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84312524
185POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83881801
186LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83844702
187EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83803105
188NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82761092
189AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81386753
190SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81278700
191RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81042563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception7.45445330
2MP0002735_abnormal_chemical_nociception7.01466467
3MP0002736_abnormal_nociception_after6.61327423
4MP0001986_abnormal_taste_sensitivity5.16950282
5MP0004270_analgesia4.67820114
6MP0002796_impaired_skin_barrier4.36770166
7MP0006276_abnormal_autonomic_nervous4.21278297
8MP0002733_abnormal_thermal_nociception4.17195036
9MP0004858_abnormal_nervous_system3.92815680
10MP0002734_abnormal_mechanical_nocicepti3.85713477
11MP0001970_abnormal_pain_threshold3.61646029
12MP0008995_early_reproductive_senescence3.29456177
13MP0000647_abnormal_sebaceous_gland3.21165910
14MP0002098_abnormal_vibrissa_morphology2.71936878
15MP0004185_abnormal_adipocyte_glucose2.66484510
16MP0005501_abnormal_skin_physiology2.57432174
17MP0004782_abnormal_surfactant_physiolog2.50778414
18MP0004859_abnormal_synaptic_plasticity2.45078208
19MP0002272_abnormal_nervous_system2.39745452
20MP0004147_increased_porphyrin_level2.34314405
21MP0003880_abnormal_central_pattern2.05799832
22MP0010307_abnormal_tumor_latency2.04223056
23MP0008004_abnormal_stomach_pH11.2145758
24MP0000003_abnormal_adipose_tissue1.98537395
25MP0000516_abnormal_urinary_system1.94831199
26MP0005367_renal/urinary_system_phenotyp1.94831199
27MP0002751_abnormal_autonomic_nervous1.90546018
28MP0002067_abnormal_sensory_capabilities1.89271785
29MP0009379_abnormal_foot_pigmentation1.86455798
30MP0009672_abnormal_birth_weight1.84454526
31MP0003303_peritoneal_inflammation1.72012667
32MP0002184_abnormal_innervation1.71576693
33MP0003635_abnormal_synaptic_transmissio1.65157967
34MP0009333_abnormal_splenocyte_physiolog1.62861886
35MP0000372_irregular_coat_pigmentation1.61408827
36MP0005670_abnormal_white_adipose1.59193540
37MP0005375_adipose_tissue_phenotype1.58699064
38MP0001348_abnormal_lacrimal_gland1.58692485
39MP0008877_abnormal_DNA_methylation1.51226193
40MP0000920_abnormal_myelination1.49190440
41MP0008260_abnormal_autophagy1.47900625
42MP0004811_abnormal_neuron_physiology1.47634223
43MP0002064_seizures1.41150067
44MP0005636_abnormal_mineral_homeostasis1.40533348
45MP0001764_abnormal_homeostasis1.36078352
46MP0000377_abnormal_hair_follicle1.34823809
47MP0005646_abnormal_pituitary_gland1.34764354
48MP0000955_abnormal_spinal_cord1.34656263
49MP0003693_abnormal_embryo_hatching1.34311582
50MP0002127_abnormal_cardiovascular_syste1.33225936
51MP0005666_abnormal_adipose_tissue1.29422302
52MP0005083_abnormal_biliary_tract1.28428707
53MP0009745_abnormal_behavioral_response1.26172234
54MP0009046_muscle_twitch1.25103072
55MP0005397_hematopoietic_system_phenotyp1.24888553
56MP0001545_abnormal_hematopoietic_system1.24888553
57MP0003786_premature_aging1.24651959
58MP0003329_amyloid_beta_deposits1.23848171
59MP0009115_abnormal_fat_cell1.20547760
60MP0003634_abnormal_glial_cell1.20398541
61MP0003186_abnormal_redox_activity1.19598664
62MP0003656_abnormal_erythrocyte_physiolo1.19065633
63MP0005423_abnormal_somatic_nervous1.18416929
64MP0001485_abnormal_pinna_reflex1.17537373
65MP0002063_abnormal_learning/memory/cond1.16040334
66MP0001216_abnormal_epidermal_layer1.14848424
67MP0000383_abnormal_hair_follicle1.11958594
68MP0009697_abnormal_copulation1.10867204
69MP0002572_abnormal_emotion/affect_behav1.09919533
70MP0008874_decreased_physiological_sensi1.09751224
71MP0001270_distended_abdomen1.09670596
72MP0001486_abnormal_startle_reflex1.08734445
73MP0003633_abnormal_nervous_system1.08719055
74MP0001984_abnormal_olfaction1.08143898
75MP0004957_abnormal_blastocyst_morpholog1.07292788
76MP0001730_embryonic_growth_arrest1.06258850
77MP0002882_abnormal_neuron_morphology1.02605355
78MP0004233_abnormal_muscle_weight1.01452702
79MP0010094_abnormal_chromosome_stability1.00861993
80MP0000778_abnormal_nervous_system1.00087555
81MP0009703_decreased_birth_body0.99870143
82MP0000749_muscle_degeneration0.99862577
83MP0002229_neurodegeneration0.99029055
84MP0005023_abnormal_wound_healing0.98855141
85MP0001346_abnormal_lacrimal_gland0.95998082
86MP0003631_nervous_system_phenotype0.95329451
87MP0000747_muscle_weakness0.94629603
88MP0002160_abnormal_reproductive_system0.92715605
89MP0000367_abnormal_coat/_hair0.92568103
90MP0005171_absent_coat_pigmentation0.90174810
91MP0002066_abnormal_motor_capabilities/c0.89682685
92MP0010771_integument_phenotype0.88081377
93MP0000230_abnormal_systemic_arterial0.87104452
94MP0002086_abnormal_extraembryonic_tissu0.87101145
95MP0004264_abnormal_extraembryonic_tissu0.86840551
96MP0008789_abnormal_olfactory_epithelium0.86687906
97MP0002837_dystrophic_cardiac_calcinosis0.85765751
98MP0008775_abnormal_heart_ventricle0.85442240
99MP0009840_abnormal_foam_cell0.85426950
100MP0010678_abnormal_skin_adnexa0.84243266
101MP0001727_abnormal_embryo_implantation0.82146516
102MP0001663_abnormal_digestive_system0.81630685
103MP0000604_amyloidosis0.79531953
104MP0001243_abnormal_dermal_layer0.77413167
105MP0003045_fibrosis0.76962583
106MP0003448_altered_tumor_morphology0.76006603
107MP0003936_abnormal_reproductive_system0.75204376
108MP0000358_abnormal_cell_content/0.74930595
109MP0000013_abnormal_adipose_tissue0.74152164
110MP0005535_abnormal_body_temperature0.73911921
111MP0003632_abnormal_nervous_system0.73272151
112MP0004742_abnormal_vestibular_system0.73146746
113MP0002638_abnormal_pupillary_reflex0.71026616
114MP0003718_maternal_effect0.70801503
115MP0003942_abnormal_urinary_system0.69306097
116MP0004142_abnormal_muscle_tone0.68717251
117MP0002752_abnormal_somatic_nervous0.68065594
118MP0003878_abnormal_ear_physiology0.68013471
119MP0005377_hearing/vestibular/ear_phenot0.68013471
120MP0002210_abnormal_sex_determination0.67974972
121MP0002396_abnormal_hematopoietic_system0.67631433
122MP0005165_increased_susceptibility_to0.67487882
123MP0000470_abnormal_stomach_morphology0.67038635
124MP0001697_abnormal_embryo_size0.65186313
125MP0000427_abnormal_hair_cycle0.64580618
126MP0002909_abnormal_adrenal_gland0.63718863
127MP0001672_abnormal_embryogenesis/_devel0.63653163
128MP0005380_embryogenesis_phenotype0.63653163
129MP0005381_digestive/alimentary_phenotyp0.62822918
130MP0002876_abnormal_thyroid_physiology0.62622096
131MP0002557_abnormal_social/conspecific_i0.62320442
132MP0005389_reproductive_system_phenotype0.62206498
133MP0001881_abnormal_mammary_gland0.62170529
134MP0001440_abnormal_grooming_behavior0.61580837
135MP0005623_abnormal_meninges_morphology0.60850714
136MP0005499_abnormal_olfactory_system0.60449700
137MP0005394_taste/olfaction_phenotype0.60449700
138MP0008569_lethality_at_weaning0.59886410
139MP0001905_abnormal_dopamine_level0.59612808
140MP0005085_abnormal_gallbladder_physiolo0.59462463
141MP0000751_myopathy0.59461415
142MP0000534_abnormal_ureter_morphology0.59048605
143MP0004085_abnormal_heartbeat0.58965592
144MP0000579_abnormal_nail_morphology0.58759231
145MP0004924_abnormal_behavior0.58497857
146MP0005386_behavior/neurological_phenoty0.58497857
147MP0002080_prenatal_lethality0.58360515
148MP0008770_decreased_survivor_rate0.57539696
149MP0002970_abnormal_white_adipose0.57539180
150MP0000538_abnormal_urinary_bladder0.56049994
151MP0001661_extended_life_span0.55733229
152MP0008932_abnormal_embryonic_tissue0.53956295
153MP0001756_abnormal_urination0.53943839
154MP0001145_abnormal_male_reproductive0.53454280
155MP0002088_abnormal_embryonic_growth/wei0.53217082
156MP0003984_embryonic_growth_retardation0.52776887
157MP0006035_abnormal_mitochondrial_morpho0.52426898
158MP0005448_abnormal_energy_balance0.52348763
159MP0009931_abnormal_skin_appearance0.52243219
160MP0003136_yellow_coat_color0.51563455
161MP0004484_altered_response_of0.51264190
162MP0010234_abnormal_vibrissa_follicle0.50601804
163MP0003690_abnormal_glial_cell0.50313152
164MP0004036_abnormal_muscle_relaxation0.48276438
165MP0005451_abnormal_body_composition0.48165473
166MP0001299_abnormal_eye_distance/0.47428548
167MP0003283_abnormal_digestive_organ0.45867795
168MP0001188_hyperpigmentation0.44799138
169MP0001765_abnormal_ion_homeostasis0.44121832
170MP0004145_abnormal_muscle_electrophysio0.43707280
171MP0004510_myositis0.41232456
172MP0008872_abnormal_physiological_respon0.40621874
173MP0001963_abnormal_hearing_physiology0.40188433
174MP0001664_abnormal_digestion0.40062905
175MP0003806_abnormal_nucleotide_metabolis0.39083784
176MP0004883_abnormal_blood_vessel0.38771396
177MP0002972_abnormal_cardiac_muscle0.37027011
178MP0001501_abnormal_sleep_pattern0.36974388
179MP0004215_abnormal_myocardial_fiber0.33599893
180MP0000639_abnormal_adrenal_gland0.33082293
181MP0005464_abnormal_platelet_physiology0.32914924

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.14856853
2Amelogenesis imperfecta (HP:0000705)7.49289348
3Segmental peripheral demyelination/remyelination (HP:0003481)7.18322357
4Insidious onset (HP:0003587)6.73533124
5Termporal pattern (HP:0011008)6.73533124
6Aplastic anemia (HP:0001915)6.32193663
7Action tremor (HP:0002345)6.28869295
8Abnormality of dental color (HP:0011073)5.96236664
9Myokymia (HP:0002411)5.88868586
10Fragile nails (HP:0001808)5.72725282
11Woolly hair (HP:0002224)5.50675478
12Dysautonomia (HP:0002459)5.49374213
13Abnormality of the frontal sinuses (HP:0002687)5.28478371
14Onion bulb formation (HP:0003383)4.80711169
15Male infertility (HP:0003251)4.80126952
16Impaired pain sensation (HP:0007328)4.78150314
17Abnormality of pain sensation (HP:0010832)4.78150314
18Supranuclear gaze palsy (HP:0000605)4.72047952
19Microvesicular hepatic steatosis (HP:0001414)4.70205815
20Foot dorsiflexor weakness (HP:0009027)4.66481687
21Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.55135803
22Steppage gait (HP:0003376)4.38677153
23Cerebral hypomyelination (HP:0006808)4.37550095
24Peripheral hypomyelination (HP:0007182)4.34967229
25Hammertoe (HP:0001765)4.32903158
26Abnormality of the foot musculature (HP:0001436)4.20358066
27Pheochromocytoma (HP:0002666)4.01194596
28Abnormality of pyrimidine metabolism (HP:0004353)3.95876754
29Paralysis (HP:0003470)3.88958591
30Abnormality of cells of the erythroid lineage (HP:0012130)3.85143699
31Seborrheic dermatitis (HP:0001051)3.83772135
32Abnormal number of erythroid precursors (HP:0012131)3.81223049
33Abnormal autonomic nervous system physiology (HP:0012332)3.71481118
34Right ventricular cardiomyopathy (HP:0011663)3.70317771
35Axonal loss (HP:0003447)3.55166893
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52830718
37Impaired proprioception (HP:0010831)3.52048341
38Retinal atrophy (HP:0001105)3.52005773
39Abnormality of the dental root (HP:0006486)3.49508885
40Taurodontia (HP:0000679)3.49508885
41Abnormality of permanent molar morphology (HP:0011071)3.49508885
42Sensory axonal neuropathy (HP:0003390)3.46363588
43Neuroendocrine neoplasm (HP:0100634)3.43862282
44Hypergonadotropic hypogonadism (HP:0000815)3.42985791
45Focal seizures (HP:0007359)3.41600616
46Distal sensory impairment (HP:0002936)3.34368672
47Bilateral sensorineural hearing impairment (HP:0008619)3.32937362
48Decreased motor nerve conduction velocity (HP:0003431)3.30626281
49Increased neuronal autofluorescent lipopigment (HP:0002074)3.27828432
50Increased CSF protein (HP:0002922)3.27233345
51Peripheral demyelination (HP:0011096)3.25999412
52Distal arthrogryposis (HP:0005684)3.23635182
53Hyporeflexia of lower limbs (HP:0002600)3.22818017
54Abnormality of molar (HP:0011077)3.22646213
55Abnormality of molar morphology (HP:0011070)3.22646213
56Myotonia (HP:0002486)3.22355686
57Cerebellar dysplasia (HP:0007033)3.20357987
58Abnormality of the dental pulp (HP:0006479)3.11588020
59Abnormality of transition element cation homeostasis (HP:0011030)3.07238047
60Abnormality of the corticospinal tract (HP:0002492)3.05107616
61Focal motor seizures (HP:0011153)2.97702286
62Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.94769266
63Abnormality of the vocal cords (HP:0008777)2.92774078
64Birth length less than 3rd percentile (HP:0003561)2.92216775
65Breast hypoplasia (HP:0003187)2.91285405
66Visual hallucinations (HP:0002367)2.90640138
67Postural tremor (HP:0002174)2.89749146
68Abnormality of iron homeostasis (HP:0011031)2.89026901
69Increased circulating renin level (HP:0000848)2.84668532
70Upper limb muscle weakness (HP:0003484)2.84479642
71Autoamputation (HP:0001218)2.82173431
72Ventricular fibrillation (HP:0001663)2.70206919
73Premature ovarian failure (HP:0008209)2.67777523
74Carpal bone hypoplasia (HP:0001498)2.67180864
75Hepatocellular necrosis (HP:0001404)2.66197616
76Increased serum ferritin (HP:0003281)2.66143674
77Renal tubular acidosis (HP:0001947)2.66091808
78CNS hypomyelination (HP:0003429)2.65158856
79Increased cerebral lipofuscin (HP:0011813)2.64956530
80Aplasia of the musculature (HP:0100854)2.64893985
81Urinary urgency (HP:0000012)2.64704809
82Vacuolated lymphocytes (HP:0001922)2.64479851
83Progressive muscle weakness (HP:0003323)2.58721519
84Rapidly progressive (HP:0003678)2.57718356
85Ankle clonus (HP:0011448)2.57351314
86Pallor (HP:0000980)2.56876883
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55890251
88Increased serum lactate (HP:0002151)2.53712707
89Neurofibrillary tangles (HP:0002185)2.53314757
90Malnutrition (HP:0004395)2.52440813
91Hypothermia (HP:0002045)2.50797960
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46672111
93Septate vagina (HP:0001153)2.46445289
94Abnormal pancreas size (HP:0012094)2.45254530
95Tetany (HP:0001281)2.42657646
96Nausea (HP:0002018)2.39192042
97Increased CSF lactate (HP:0002490)2.38544921
98Widely spaced teeth (HP:0000687)2.38499866
99Reticulocytopenia (HP:0001896)2.38074566
100Dialeptic seizures (HP:0011146)2.36464791
101Bradycardia (HP:0001662)2.35908621
102Abnormality of magnesium homeostasis (HP:0004921)2.34531563
103Hypomagnesemia (HP:0002917)2.33988887
104Severe visual impairment (HP:0001141)2.33545863
105Hypoventilation (HP:0002791)2.32099880
106Atonic seizures (HP:0010819)2.31299363
107Degeneration of the lateral corticospinal tracts (HP:0002314)2.30416697
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30416697
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29218079
110Renal tubular dysfunction (HP:0000124)2.28056364
111Aplasia/Hypoplasia involving the musculature (HP:0001460)2.25484928
112Lactic acidosis (HP:0003128)2.19392031
113Hepatic necrosis (HP:0002605)2.18584071
114Hyperglycinuria (HP:0003108)2.17986759
115Progressive inability to walk (HP:0002505)2.16598616
116CNS demyelination (HP:0007305)2.14041856
117Thyroid carcinoma (HP:0002890)2.11120542
118Progressive cerebellar ataxia (HP:0002073)2.08826928
119Failure to thrive in infancy (HP:0001531)2.08803821
120Ureteral duplication (HP:0000073)2.07540755
121Split foot (HP:0001839)2.06628049
122Lower limb muscle weakness (HP:0007340)2.05100439
123Arthropathy (HP:0003040)2.02835776
124Generalized tonic-clonic seizures (HP:0002069)2.02111526
125Abnormality of the aortic arch (HP:0012303)2.00785954
126Spastic gait (HP:0002064)2.00590478
127Hyperglycemia (HP:0003074)2.00503977
128Thoracolumbar scoliosis (HP:0002944)1.99903862
129Insomnia (HP:0100785)1.98821321
130Abnormality of calcium-phosphate metabolism (HP:0100530)1.98317167
131Neoplasm of the peripheral nervous system (HP:0100007)1.97421355
132Craniofacial hyperostosis (HP:0004493)1.96427722
133Hypercortisolism (HP:0001578)1.96231396
134Morphological abnormality of the pyramidal tract (HP:0002062)1.96094161
135Bile duct proliferation (HP:0001408)1.95692963
136Abnormal biliary tract physiology (HP:0012439)1.95692963
137Cerebral hemorrhage (HP:0001342)1.95213815
138Truncal ataxia (HP:0002078)1.93243689
139Mitochondrial inheritance (HP:0001427)1.92629347
140Distal lower limb muscle weakness (HP:0009053)1.91571207
141Cone-rod dystrophy (HP:0000548)1.88742312
142Cerebral inclusion bodies (HP:0100314)1.88730630
143Osteomalacia (HP:0002749)1.88598280
144Aplasia/hypoplasia of the uterus (HP:0008684)1.88419249
145Rough bone trabeculation (HP:0100670)1.88071951
146EMG: neuropathic changes (HP:0003445)1.87695342
147Prolonged QT interval (HP:0001657)1.87435757
148Postural instability (HP:0002172)1.86228074
149Proximal tubulopathy (HP:0000114)1.85140989
150Absent forearm bone (HP:0003953)1.84369810
151Aplasia involving forearm bones (HP:0009822)1.84369810
152Increased hepatocellular lipid droplets (HP:0006565)1.83762787
153Muscle fibrillation (HP:0010546)1.83595994
154Absence seizures (HP:0002121)1.83085462
155Muscle fiber splitting (HP:0003555)1.81790228
156Secondary amenorrhea (HP:0000869)1.80790349
157Glycosuria (HP:0003076)1.80663324
158Abnormality of urine glucose concentration (HP:0011016)1.80663324
159Facial shape deformation (HP:0011334)1.79355271
160Potter facies (HP:0002009)1.79355271
161Congenital ichthyosiform erythroderma (HP:0007431)1.79337875
162Neuronal loss in central nervous system (HP:0002529)1.78327082
163Hypoplasia of the uterus (HP:0000013)1.78254670
164Multiple enchondromatosis (HP:0005701)1.78080113
165Azoospermia (HP:0000027)1.77494082
166Episodic fever (HP:0001954)1.75540335
167Cholecystitis (HP:0001082)1.74972959
168Abnormal gallbladder physiology (HP:0012438)1.74972959
169Pancytopenia (HP:0001876)1.74617847
170Absent radius (HP:0003974)1.73964225
171Abnormal umbilical cord blood vessels (HP:0011403)1.73200094
172Single umbilical artery (HP:0001195)1.73200094
173Abnormality of the fetal cardiovascular system (HP:0010948)1.73200094
174Death in infancy (HP:0001522)1.72660049
175Neonatal onset (HP:0003623)1.72156823
176Febrile seizures (HP:0002373)1.71295947
177Pes cavus (HP:0001761)1.71023742
178Partial agenesis of the corpus callosum (HP:0001338)1.70944582
179Slow progression (HP:0003677)1.70804598
180Orthostatic hypotension (HP:0001278)1.70543886
181Double outlet right ventricle (HP:0001719)1.70229340
182Congenital malformation of the right heart (HP:0011723)1.70229340
183Bicornuate uterus (HP:0000813)1.69317565
184Lower limb asymmetry (HP:0100559)1.66862352
185Muscle stiffness (HP:0003552)1.64447471
186Urinary bladder sphincter dysfunction (HP:0002839)1.64369532
187Abnormal eating behavior (HP:0100738)1.63473427
188Areflexia of lower limbs (HP:0002522)1.63370568
189Amblyopia (HP:0000646)1.60156083
190Broad alveolar ridges (HP:0000187)1.60079385
191Stridor (HP:0010307)1.58980393
192Paraplegia (HP:0010550)1.58895873
193Anosmia (HP:0000458)1.57983304
194Bowel diverticulosis (HP:0005222)1.57543194
195Spastic paraplegia (HP:0001258)1.55739050
196Hypoplasia of the brainstem (HP:0002365)1.54934231
197Aplasia/Hypoplasia of the brainstem (HP:0007362)1.54934231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.34702468
2KSR25.14140790
3EPHA24.65267475
4MAP3K24.34563905
5NTRK13.91834856
6PDK23.82917244
7TYRO33.62977972
8RIPK43.54124754
9NTRK33.47624812
10LIMK13.42440718
11NME13.09497217
12SIK33.05739436
13AKT33.05709637
14OXSR12.93713604
15GRK52.89233742
16LMTK22.79940540
17PBK2.79021070
18MINK12.51544074
19MATK2.32369241
20MAP3K92.25156628
21BUB12.25015279
22RET2.14344833
23CDK192.09188718
24MARK32.02614134
25PAK61.91321814
26MAP2K21.82117997
27PLK41.78199460
28MAP3K11.69420717
29SIK21.60681247
30LATS21.55371851
31TESK21.52577205
32MAP2K11.49004158
33CDK41.47530475
34EPHA31.41544759
35GSK3A1.36138553
36ADRBK21.34560501
37STK391.34170408
38BRAF1.33251637
39AURKA1.32545854
40CDK61.26611129
41ADRBK11.24391047
42PHKG11.24326976
43PHKG21.24326976
44PAK41.21252548
45PIM11.21090388
46PLK11.21012277
47STK161.19437630
48CSK1.17534835
49ARAF1.15935861
50PINK11.14245830
51SGK2231.13234251
52SGK4941.13234251
53EPHB11.09352962
54SRPK11.07764918
55CASK1.06471604
56RPS6KA21.01812535
57IRAK21.01308856
58MARK20.98861808
59PRKCQ0.98205435
60CHEK10.97356068
61EIF2AK10.94866388
62WNK10.93693862
63TTK0.93654565
64MAP3K120.93158768
65MAP3K130.90871964
66PRKAA10.86166025
67UHMK10.85116678
68CSNK1G30.83634182
69CSNK1A1L0.82356736
70CDK50.81527448
71PRKCE0.78038278
72NEK10.75796900
73CSNK1G20.75229113
74BRD40.74808695
75EPHB20.74317061
76PLK20.73765969
77AKT20.73535438
78PAK10.70095255
79AURKB0.69011115
80WNK40.67349434
81CDK140.67323896
82PRKCD0.66816653
83LRRK20.66566530
84SIK10.65602448
85MAP3K40.65369814
86CHEK20.64679364
87PDPK10.64219395
88RPS6KB20.62718760
89FER0.62244065
90STK38L0.60695295
91PDK10.59983312
92TRPM70.58537659
93DYRK20.58198939
94LATS10.58069730
95FGR0.57382018
96CDC42BPA0.57071195
97ROCK20.57039932
98RAF10.56870307
99STK100.56709376
100PRKCG0.56410739
101MAP3K70.55784627
102KSR10.53870710
103FRK0.53801843
104CSNK1G10.53543718
105MARK10.53148911
106TESK10.52786213
107SCYL20.51725070
108MET0.50838751
109PKN10.50710237
110MELK0.50658895
111DAPK20.50504182
112PRKD30.49454603
113FES0.49069194
114STK40.48838365
115MAPK130.48651791
116EGFR0.48130876
117MST1R0.47766876
118PRKG20.47469693
119CAMK2A0.47403267
120PIM20.46703294
121YES10.46455700
122MAP2K40.44459106
123ABL10.43484016
124TNIK0.43172774
125NTRK20.43091957
126PRKAA20.42886018
127BCKDK0.42062317
128SRC0.40763575
129FGFR30.39702132
130TNK20.39530016
131MAPKAPK50.39139568
132FYN0.38659559
133CAMK2G0.38076406
134MST40.37697977
135JAK20.37324531
136SGK20.36907728
137ROCK10.36568384
138CAMK2D0.36427033
139PRKACA0.35754209
140PRKCI0.35271471
141CDK20.35112691
142CDK180.34032116
143PRKCH0.33927031
144HIPK20.33522456
145RPS6KA10.33443049
146PRKCZ0.33354119
147CAMKK10.32991842
148NEK60.32210352
149JAK30.31989125
150SGK30.30300875
151ABL20.30199003
152PRKCB0.30123864
153VRK20.30090906
154PTK20.29673233
155CSNK2A10.28116361
156CDK150.27073660
157PRKCA0.26623324
158MAP3K80.26465227
159FGFR40.26270721
160MAPK100.26179664
161ILK0.25883065
162CSNK2A20.25082000
163BRSK10.24534472
164RPS6KA40.23056543
165RPS6KB10.22857855
166CDK10.22236339
167MAPK10.22002713
168MTOR0.21489950
169ERBB40.20971499
170CDK70.19279074
171MAP3K60.19246794
172STK380.18223435
173DAPK10.16902406
174AKT10.16299960
175GRK60.16090398
176KDR0.15684693

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.12262475
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.26985834
3RNA polymerase_Homo sapiens_hsa030202.99956188
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94438699
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.74153068
6Sulfur relay system_Homo sapiens_hsa041222.72521945
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.72434179
8Synaptic vesicle cycle_Homo sapiens_hsa047212.63405546
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.37461115
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.33824409
11Dorso-ventral axis formation_Homo sapiens_hsa043202.32200243
12Proteasome_Homo sapiens_hsa030502.31981132
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24380880
14RNA transport_Homo sapiens_hsa030132.16188976
15Arginine biosynthesis_Homo sapiens_hsa002202.07721140
16Pyrimidine metabolism_Homo sapiens_hsa002402.02650165
17Thyroid cancer_Homo sapiens_hsa052162.01349099
18p53 signaling pathway_Homo sapiens_hsa041152.01097698
19mRNA surveillance pathway_Homo sapiens_hsa030151.95774691
20DNA replication_Homo sapiens_hsa030301.91754389
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89329841
22Olfactory transduction_Homo sapiens_hsa047401.78846621
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.76133087
24Base excision repair_Homo sapiens_hsa034101.76120919
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.73933069
26Insulin secretion_Homo sapiens_hsa049111.70223495
27Glutamatergic synapse_Homo sapiens_hsa047241.65271922
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64966289
29Oxidative phosphorylation_Homo sapiens_hsa001901.55603511
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.55546281
31Collecting duct acid secretion_Homo sapiens_hsa049661.49847713
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41785793
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39812953
34Glutathione metabolism_Homo sapiens_hsa004801.36188142
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35785571
36Cholinergic synapse_Homo sapiens_hsa047251.35647729
37Nitrogen metabolism_Homo sapiens_hsa009101.34424746
38Folate biosynthesis_Homo sapiens_hsa007901.34084059
39One carbon pool by folate_Homo sapiens_hsa006701.33439404
40Taste transduction_Homo sapiens_hsa047421.33308736
41Dopaminergic synapse_Homo sapiens_hsa047281.32904846
42Long-term potentiation_Homo sapiens_hsa047201.31377306
43Circadian entrainment_Homo sapiens_hsa047131.30655388
44Serotonergic synapse_Homo sapiens_hsa047261.30527877
45Cardiac muscle contraction_Homo sapiens_hsa042601.29103624
46Arginine and proline metabolism_Homo sapiens_hsa003301.26988341
47Glioma_Homo sapiens_hsa052141.26671949
48Parkinsons disease_Homo sapiens_hsa050121.25287659
49Salivary secretion_Homo sapiens_hsa049701.23397013
50Alzheimers disease_Homo sapiens_hsa050101.23067595
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21891339
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.20925373
53Regulation of autophagy_Homo sapiens_hsa041401.20340219
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.19797795
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17687439
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17264553
57Selenocompound metabolism_Homo sapiens_hsa004501.17029630
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16673322
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15551141
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15120443
61RNA degradation_Homo sapiens_hsa030181.13309440
62GABAergic synapse_Homo sapiens_hsa047271.12712473
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.12447337
64Hippo signaling pathway_Homo sapiens_hsa043901.12005443
65Morphine addiction_Homo sapiens_hsa050321.11883641
66Cell cycle_Homo sapiens_hsa041101.11734140
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10096550
68VEGF signaling pathway_Homo sapiens_hsa043701.08109133
69Axon guidance_Homo sapiens_hsa043601.07672377
70Estrogen signaling pathway_Homo sapiens_hsa049151.06338379
71Steroid biosynthesis_Homo sapiens_hsa001001.06119749
72Salmonella infection_Homo sapiens_hsa051321.03468868
73Choline metabolism in cancer_Homo sapiens_hsa052311.01990161
74Spliceosome_Homo sapiens_hsa030401.00037338
75Glycerolipid metabolism_Homo sapiens_hsa005610.99331778
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.98695061
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98114781
78Prion diseases_Homo sapiens_hsa050200.98012145
79Long-term depression_Homo sapiens_hsa047300.96548080
80Melanoma_Homo sapiens_hsa052180.96366777
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.96205134
82Hedgehog signaling pathway_Homo sapiens_hsa043400.95738701
83Vibrio cholerae infection_Homo sapiens_hsa051100.95597479
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.93709810
85GnRH signaling pathway_Homo sapiens_hsa049120.93493532
86Phagosome_Homo sapiens_hsa041450.91916784
87Biosynthesis of amino acids_Homo sapiens_hsa012300.91414404
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.89697106
89Basal transcription factors_Homo sapiens_hsa030220.89642895
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87653185
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87394852
92Gap junction_Homo sapiens_hsa045400.87084087
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87054318
94Small cell lung cancer_Homo sapiens_hsa052220.83393504
95Ether lipid metabolism_Homo sapiens_hsa005650.83206286
96Gastric acid secretion_Homo sapiens_hsa049710.81075110
97Type II diabetes mellitus_Homo sapiens_hsa049300.80794012
98Melanogenesis_Homo sapiens_hsa049160.80511447
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80265436
100ErbB signaling pathway_Homo sapiens_hsa040120.79753483
101Nicotine addiction_Homo sapiens_hsa050330.79551546
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78193368
103Galactose metabolism_Homo sapiens_hsa000520.76934061
104Purine metabolism_Homo sapiens_hsa002300.75888655
105Insulin signaling pathway_Homo sapiens_hsa049100.75343126
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.74706468
107Bile secretion_Homo sapiens_hsa049760.72563832
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72410914
109Renin-angiotensin system_Homo sapiens_hsa046140.72388410
110Pancreatic secretion_Homo sapiens_hsa049720.71938152
111Basal cell carcinoma_Homo sapiens_hsa052170.71809242
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71743013
113beta-Alanine metabolism_Homo sapiens_hsa004100.70374899
114Fatty acid elongation_Homo sapiens_hsa000620.69421210
115Endometrial cancer_Homo sapiens_hsa052130.69302569
116Vitamin digestion and absorption_Homo sapiens_hsa049770.69061311
117Metabolic pathways_Homo sapiens_hsa011000.67616899
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66038094
119Homologous recombination_Homo sapiens_hsa034400.65231794
120Amphetamine addiction_Homo sapiens_hsa050310.64918179
121Acute myeloid leukemia_Homo sapiens_hsa052210.64061936
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64040482
123Endocytosis_Homo sapiens_hsa041440.63021365
124Mismatch repair_Homo sapiens_hsa034300.61929124
125Mineral absorption_Homo sapiens_hsa049780.61228837
126Linoleic acid metabolism_Homo sapiens_hsa005910.59191623
127Renin secretion_Homo sapiens_hsa049240.58948302
128Thyroid hormone synthesis_Homo sapiens_hsa049180.58685170
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58530031
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57761496
131Prolactin signaling pathway_Homo sapiens_hsa049170.57473086
132mTOR signaling pathway_Homo sapiens_hsa041500.56840588
133Ras signaling pathway_Homo sapiens_hsa040140.56770568
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56549194
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54571573
136Oxytocin signaling pathway_Homo sapiens_hsa049210.54491559
137Calcium signaling pathway_Homo sapiens_hsa040200.54359816
138Carbon metabolism_Homo sapiens_hsa012000.53777897
139Protein export_Homo sapiens_hsa030600.53099335
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52225597
141Huntingtons disease_Homo sapiens_hsa050160.51605435
142Lysosome_Homo sapiens_hsa041420.51278327
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49213795
144Rap1 signaling pathway_Homo sapiens_hsa040150.48856957
145Oocyte meiosis_Homo sapiens_hsa041140.48141846
146Amoebiasis_Homo sapiens_hsa051460.47827788
147Protein digestion and absorption_Homo sapiens_hsa049740.47392016
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47347310
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47143838
150Pathways in cancer_Homo sapiens_hsa052000.46449988
151Complement and coagulation cascades_Homo sapiens_hsa046100.45266575
152African trypanosomiasis_Homo sapiens_hsa051430.43534310
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42987697
154Fanconi anemia pathway_Homo sapiens_hsa034600.41745467
155Rheumatoid arthritis_Homo sapiens_hsa053230.41522163
156Phototransduction_Homo sapiens_hsa047440.41484006
157Fructose and mannose metabolism_Homo sapiens_hsa000510.40004549
158Nucleotide excision repair_Homo sapiens_hsa034200.39555188
159Non-homologous end-joining_Homo sapiens_hsa034500.39320348
160TGF-beta signaling pathway_Homo sapiens_hsa043500.38409093
161Cyanoamino acid metabolism_Homo sapiens_hsa004600.36688755
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35729439
163Ovarian steroidogenesis_Homo sapiens_hsa049130.34192228
164Measles_Homo sapiens_hsa051620.33146835
165Prostate cancer_Homo sapiens_hsa052150.32813028
166Pyruvate metabolism_Homo sapiens_hsa006200.32012871
167Sulfur metabolism_Homo sapiens_hsa009200.31992233
168ABC transporters_Homo sapiens_hsa020100.30803445
169PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29461781
170N-Glycan biosynthesis_Homo sapiens_hsa005100.29140686
171Inositol phosphate metabolism_Homo sapiens_hsa005620.28870174
172Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27447347
173Glycosaminoglycan degradation_Homo sapiens_hsa005310.21318783

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