MRGPRX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)6.12010538
2detection of bacterium (GO:0016045)5.90353583
3regulation of dendritic cell antigen processing and presentation (GO:0002604)5.54078530
4detection of other organism (GO:0098543)5.43878763
5positive regulation of antigen processing and presentation (GO:0002579)5.29753533
6sphingomyelin metabolic process (GO:0006684)5.01167302
7regulation of cellular extravasation (GO:0002691)4.56270026
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.42967441
9regulation of antigen processing and presentation (GO:0002577)4.36975489
10regulation of double-strand break repair via homologous recombination (GO:0010569)4.18444729
11paraxial mesoderm development (GO:0048339)4.15690029
12embryonic camera-type eye morphogenesis (GO:0048596)4.11901345
13superoxide anion generation (GO:0042554)4.09476593
14pyrimidine nucleotide catabolic process (GO:0006244)4.05396956
15spinal cord association neuron differentiation (GO:0021527)4.02952318
16epithelial cell maturation (GO:0002070)3.91696148
17positive regulation of interleukin-1 beta secretion (GO:0050718)3.88657844
18mitotic metaphase plate congression (GO:0007080)3.87179842
19wound healing, spreading of epidermal cells (GO:0035313)3.84076622
20pituitary gland development (GO:0021983)3.75150061
21peptidyl-arginine N-methylation (GO:0035246)3.65741595
22peptidyl-arginine methylation (GO:0018216)3.65741595
23regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.65738028
24positive regulation of interleukin-1 secretion (GO:0050716)3.56747929
25positive regulation of monocyte chemotaxis (GO:0090026)3.55829218
26peptidyl-arginine omega-N-methylation (GO:0035247)3.54902682
27regulation of pseudopodium assembly (GO:0031272)3.48920176
28positive regulation of interleukin-1 beta production (GO:0032731)3.47883479
29regulation of chemokine secretion (GO:0090196)3.44574490
30positive regulation of extracellular matrix organization (GO:1903055)3.36466935
31induction of positive chemotaxis (GO:0050930)3.35508684
32positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.32266940
33regulation of interleukin-1 beta secretion (GO:0050706)3.32229747
34neural crest cell development (GO:0014032)3.29227183
35positive regulation of chemokine secretion (GO:0090197)3.28324022
36detection of external biotic stimulus (GO:0098581)3.25881513
37positive regulation of pseudopodium assembly (GO:0031274)3.23176628
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19740618
39meiotic chromosome segregation (GO:0045132)3.13168830
40motor neuron axon guidance (GO:0008045)3.08293338
41negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05985433
42regulation of extracellular matrix disassembly (GO:0010715)3.05069927
43auditory receptor cell differentiation (GO:0042491)3.04270087
44activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.02491380
45sphingosine metabolic process (GO:0006670)3.01518611
46positive regulation of interleukin-1 production (GO:0032732)2.98019531
47carnitine shuttle (GO:0006853)2.96335078
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93007234
49positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.91409768
50G-protein coupled receptor internalization (GO:0002031)2.89376998
51positive regulation of T cell migration (GO:2000406)2.88017877
52aldehyde catabolic process (GO:0046185)2.85675276
53stem cell development (GO:0048864)2.84423365
54tyrosine phosphorylation of STAT protein (GO:0007260)2.81475260
55cytokine biosynthetic process (GO:0042089)2.80066504
56regulation of interleukin-1 secretion (GO:0050704)2.79223566
57DNA strand renaturation (GO:0000733)2.74267847
58detection of biotic stimulus (GO:0009595)2.73890202
59regulation of double-strand break repair (GO:2000779)2.73067880
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73031232
61mesenchymal cell development (GO:0014031)2.72399267
62cellular response to gamma radiation (GO:0071480)2.71004512
63regulation of megakaryocyte differentiation (GO:0045652)2.69920462
64negative regulation of telomere maintenance (GO:0032205)2.68774473
65embryonic eye morphogenesis (GO:0048048)2.67819441
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66901838
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66879762
68histone H3-K9 methylation (GO:0051567)2.65843760
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65179745
70notochord development (GO:0030903)2.65097549
71chemosensory behavior (GO:0007635)2.64648699
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.62484078
73myelin assembly (GO:0032288)2.58906223
74homocysteine metabolic process (GO:0050667)2.58207899
75superoxide metabolic process (GO:0006801)2.57144462
76peptidyl-arginine modification (GO:0018195)2.56586197
77intra-S DNA damage checkpoint (GO:0031573)2.56462134
78cellular response to ionizing radiation (GO:0071479)2.55662627
79metaphase plate congression (GO:0051310)2.55171405
80exogenous drug catabolic process (GO:0042738)2.54316150
81viral mRNA export from host cell nucleus (GO:0046784)2.51944578
82embryonic process involved in female pregnancy (GO:0060136)2.51343855
83positive regulation of respiratory burst (GO:0060267)2.50867301
84placenta development (GO:0001890)2.49944371
85positive regulation of positive chemotaxis (GO:0050927)2.47688052
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46379452
87regulation of mitotic spindle checkpoint (GO:1903504)2.46379452
88diol metabolic process (GO:0034311)2.45558373
89fatty acid transmembrane transport (GO:1902001)2.44797688
90nucleoside diphosphate catabolic process (GO:0009134)2.43991193
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.43870457
92behavioral response to nicotine (GO:0035095)2.43840525
93regulation of positive chemotaxis (GO:0050926)2.42752932
94regulation of platelet aggregation (GO:0090330)2.40545541
95regulation of extracellular matrix organization (GO:1903053)2.39975884
96L-amino acid import (GO:0043092)2.39613143
97response to folic acid (GO:0051593)2.39593914
98myoblast differentiation (GO:0045445)2.37788722
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.37766257
100nuclear pore complex assembly (GO:0051292)2.37761978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.60632773
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.48129405
3E2F7_22180533_ChIP-Seq_HELA_Human3.40314575
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89279624
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83651231
6GBX2_23144817_ChIP-Seq_PC3_Human2.78398736
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22994279
8FLI1_27457419_Chip-Seq_LIVER_Mouse1.99143332
9EZH2_27294783_Chip-Seq_NPCs_Mouse1.94153869
10SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92719610
11NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80541580
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78871026
13NFE2_27457419_Chip-Seq_LIVER_Mouse1.77179373
14FOXM1_23109430_ChIP-Seq_U2OS_Human1.73215430
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72134811
16TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68221582
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66555965
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66255985
19TP53_16413492_ChIP-PET_HCT116_Human1.62615021
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61903339
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60614438
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.60347223
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60306824
24E2F1_18555785_Chip-Seq_ESCs_Mouse1.56834323
25SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56319790
26FUS_26573619_Chip-Seq_HEK293_Human1.56104696
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54898636
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54401235
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52464212
30AR_21909140_ChIP-Seq_LNCAP_Human1.51909493
31RXR_22108803_ChIP-Seq_LS180_Human1.51792324
32P53_22387025_ChIP-Seq_ESCs_Mouse1.49667514
33ZFX_18555785_Chip-Seq_ESCs_Mouse1.49305818
34TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49193333
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.48162824
36NMYC_18555785_Chip-Seq_ESCs_Mouse1.46678780
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.45874323
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44997018
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44957766
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44595233
41SOX2_18555785_Chip-Seq_ESCs_Mouse1.44498319
42CMYC_18555785_Chip-Seq_ESCs_Mouse1.40763532
43OCT4_18555785_Chip-Seq_ESCs_Mouse1.38046207
44P300_18555785_Chip-Seq_ESCs_Mouse1.36735144
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.36579770
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36328971
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36183775
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35409594
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34449560
50P300_19829295_ChIP-Seq_ESCs_Human1.33449723
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33241491
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.31234235
53EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31065637
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31006887
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30840383
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30840383
57KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30488143
58PU1_27457419_Chip-Seq_LIVER_Mouse1.30482306
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29840353
60GF1_26923725_Chip-Seq_HPCs_Mouse1.29447356
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.28866936
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.28446673
63TP53_18474530_ChIP-ChIP_U2OS_Human1.26753793
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.26704700
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.22091348
66AR_25329375_ChIP-Seq_VCAP_Human1.21403379
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21390990
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21390990
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20204608
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20181309
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20172652
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18571781
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.18391698
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.18230940
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.17912593
76EWS_26573619_Chip-Seq_HEK293_Human1.17053209
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.15915647
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15083408
79CJUN_26792858_Chip-Seq_BT549_Human1.13965021
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13869670
81TAF15_26573619_Chip-Seq_HEK293_Human1.12110805
82VDR_24787735_ChIP-Seq_THP-1_Human1.11740947
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10533550
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.10133693
85RNF2_27304074_Chip-Seq_NSC_Mouse1.09159444
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09066905
87SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08845007
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08676635
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08126212
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07125910
91* GATA2_21666600_ChIP-Seq_HMVEC_Human1.07029009
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06760046
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06696789
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05851742
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04513336
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03129283
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02590281
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02160019
99MYC_18940864_ChIP-ChIP_HL60_Human1.02022770
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01418556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.44944153
2MP0003787_abnormal_imprinting3.57467824
3MP0009278_abnormal_bone_marrow3.55806517
4MP0001542_abnormal_bone_strength3.24698132
5MP0002163_abnormal_gland_morphology3.08088433
6MP0009379_abnormal_foot_pigmentation3.05874496
7MP0001188_hyperpigmentation3.03284845
8MP0003123_paternal_imprinting2.96340554
9MP0003191_abnormal_cellular_cholesterol2.81120111
10MP0001545_abnormal_hematopoietic_system2.80517971
11MP0005397_hematopoietic_system_phenotyp2.80517971
12MP0006292_abnormal_olfactory_placode2.78794681
13MP0005379_endocrine/exocrine_gland_phen2.64695354
14MP0005085_abnormal_gallbladder_physiolo2.62328584
15MP0008007_abnormal_cellular_replicative2.50319761
16MP0000566_synostosis2.48917122
17MP0005451_abnormal_body_composition2.46750528
18MP0004883_abnormal_blood_vessel2.34168903
19MP0002638_abnormal_pupillary_reflex2.26571227
20MP0005248_abnormal_Harderian_gland2.12603081
21MP0003950_abnormal_plasma_membrane1.96602565
22MP0009250_abnormal_appendicular_skeleto1.88727812
23MP0003091_abnormal_cell_migration1.83680575
24MP0005171_absent_coat_pigmentation1.60343225
25MP0002396_abnormal_hematopoietic_system1.56413028
26MP0005023_abnormal_wound_healing1.54611757
27MP0000490_abnormal_crypts_of1.49049029
28MP0001790_abnormal_immune_system1.47364461
29MP0005387_immune_system_phenotype1.47364461
30MP0000613_abnormal_salivary_gland1.46998635
31MP0009384_cardiac_valve_regurgitation1.46757617
32MP0003283_abnormal_digestive_organ1.44995355
33MP0003252_abnormal_bile_duct1.43065069
34MP0002148_abnormal_hypersensitivity_rea1.40664778
35MP0000639_abnormal_adrenal_gland1.39208836
36MP0008961_abnormal_basal_metabolism1.38569228
37MP0009785_altered_susceptibility_to1.38281482
38MP0004134_abnormal_chest_morphology1.35985239
39MP0008058_abnormal_DNA_repair1.34103191
40MP0008995_early_reproductive_senescence1.33193876
41MP0009764_decreased_sensitivity_to1.32268979
42MP0003121_genomic_imprinting1.24142456
43MP0002928_abnormal_bile_duct1.22280976
44MP0003111_abnormal_nucleus_morphology1.19571620
45MP0001286_abnormal_eye_development1.19044156
46MP0003566_abnormal_cell_adhesion1.14909109
47MP0000163_abnormal_cartilage_morphology1.11432327
48MP0002933_joint_inflammation1.08841501
49MP0005645_abnormal_hypothalamus_physiol1.07220427
50MP0002115_abnormal_skeleton_extremities1.05047215
51MP0010094_abnormal_chromosome_stability1.04684430
52MP0000350_abnormal_cell_proliferation1.02552218
53MP0002113_abnormal_skeleton_development0.98585056
54MP0005083_abnormal_biliary_tract0.97616950
55MP0001958_emphysema0.95408048
56MP0002736_abnormal_nociception_after0.94768196
57MP0010352_gastrointestinal_tract_polyps0.94756056
58MP0004147_increased_porphyrin_level0.93137936
59MP0004808_abnormal_hematopoietic_stem0.92933937
60MP0005164_abnormal_response_to0.92169558
61MP0003385_abnormal_body_wall0.89802471
62MP0001915_intracranial_hemorrhage0.87987794
63MP0000432_abnormal_head_morphology0.87611533
64MP0010386_abnormal_urinary_bladder0.86267296
65MP0002109_abnormal_limb_morphology0.86084851
66MP0002998_abnormal_bone_remodeling0.85260311
67MP0000733_abnormal_muscle_development0.84606183
68MP0002277_abnormal_respiratory_mucosa0.83989222
69MP0003890_abnormal_embryonic-extraembry0.83884530
70MP0003436_decreased_susceptibility_to0.81826220
71MP0010155_abnormal_intestine_physiology0.81437006
72MP0005197_abnormal_uvea_morphology0.81029791
73MP0003705_abnormal_hypodermis_morpholog0.79208493
74MP0001919_abnormal_reproductive_system0.77701623
75MP0000462_abnormal_digestive_system0.76001466
76MP0002419_abnormal_innate_immunity0.75340636
77MP0002060_abnormal_skin_morphology0.74531634
78MP0003828_pulmonary_edema0.72877267
79MP0000249_abnormal_blood_vessel0.70271382
80MP0001119_abnormal_female_reproductive0.69606363
81MP0004484_altered_response_of0.69523668
82MP0003077_abnormal_cell_cycle0.69433137
83MP0000631_abnormal_neuroendocrine_gland0.68851095
84MP0002116_abnormal_craniofacial_bone0.66912357
85MP0002254_reproductive_system_inflammat0.65619661
86MP0002136_abnormal_kidney_physiology0.64924861
87MP0004782_abnormal_surfactant_physiolog0.64903087
88MP0001502_abnormal_circadian_rhythm0.64172090
89MP0003937_abnormal_limbs/digits/tail_de0.63779108
90MP0003763_abnormal_thymus_physiology0.63082610
91MP0003303_peritoneal_inflammation0.62275456
92MP0002233_abnormal_nose_morphology0.61455356
93MP0003755_abnormal_palate_morphology0.60437193
94MP0009765_abnormal_xenobiotic_induced0.57769889
95MP0003795_abnormal_bone_structure0.57740271
96MP0005623_abnormal_meninges_morphology0.56532257
97MP0001299_abnormal_eye_distance/0.56400892
98MP0003448_altered_tumor_morphology0.56181775
99MP0002098_abnormal_vibrissa_morphology0.55852498
100MP0004272_abnormal_basement_membrane0.55272440

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)6.18158356
2Abnormality of the nasal septum (HP:0000419)4.45032278
3Abdominal situs inversus (HP:0003363)4.34273597
4Abnormality of abdominal situs (HP:0011620)4.34273597
5Metaphyseal dysplasia (HP:0100255)4.30004288
6Absent septum pellucidum (HP:0001331)3.48622437
7Hepatoblastoma (HP:0002884)3.45355276
8Epiphyseal dysplasia (HP:0002656)3.35415355
9Prostate neoplasm (HP:0100787)3.25215173
10Abnormal number of incisors (HP:0011064)3.23592355
11Cupped ribs (HP:0000887)2.98139956
12Abnormality of the septum pellucidum (HP:0007375)2.92326091
13Growth hormone deficiency (HP:0000824)2.84857206
14Vertebral arch anomaly (HP:0008438)2.78656978
15Submucous cleft hard palate (HP:0000176)2.76051977
16Papillary thyroid carcinoma (HP:0002895)2.73203194
17Irregular epiphyses (HP:0010582)2.69353535
18Optic nerve hypoplasia (HP:0000609)2.60971886
19Anterior segment dysgenesis (HP:0007700)2.60337231
20Enlarged epiphyses (HP:0010580)2.58877997
21Neonatal hypoglycemia (HP:0001998)2.56754186
22Genu varum (HP:0002970)2.55010892
23Pulmonary artery stenosis (HP:0004415)2.47638986
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47515883
25Metaphyseal cupping (HP:0003021)2.46370579
26Adrenal hypoplasia (HP:0000835)2.44865523
27Renal tubular acidosis (HP:0001947)2.41570310
28Urethral obstruction (HP:0000796)2.40283137
29Birth length less than 3rd percentile (HP:0003561)2.38088406
30Abnormality of the parietal bone (HP:0002696)2.36582036
31Abnormality of the anterior chamber (HP:0000593)2.36174879
32Abnormality of the vertebral endplates (HP:0005106)2.35675675
33Abnormality of incisor morphology (HP:0011063)2.35653328
34Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.31877889
35Abnormality of femoral epiphyses (HP:0006499)2.31877889
36Subcapsular cataract (HP:0000523)2.31598216
37Nemaline bodies (HP:0003798)2.31135876
38Coxa vara (HP:0002812)2.30436180
39Pigmentary retinal degeneration (HP:0001146)2.30116636
40Mild short stature (HP:0003502)2.29168111
41Abnormal hemoglobin (HP:0011902)2.27339995
42Vitreoretinal degeneration (HP:0000655)2.27178851
43Abnormality of the incisor (HP:0000676)2.25701968
44Abnormality of the epiphysis of the femoral head (HP:0010574)2.24301902
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23909767
46Chorioretinal atrophy (HP:0000533)2.22002767
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21238471
48Short femoral neck (HP:0100864)2.20967056
49Flattened epiphyses (HP:0003071)2.17104312
50Abnormal tarsal ossification (HP:0008369)2.13709640
51Broad metatarsal (HP:0001783)2.12285565
52Bronchomalacia (HP:0002780)2.11786467
53Abnormal platelet volume (HP:0011876)2.11593993
54Flat capital femoral epiphysis (HP:0003370)2.10604271
55Long clavicles (HP:0000890)2.07991469
56Small epiphyses (HP:0010585)2.06960500
57Renal cortical cysts (HP:0000803)2.06702039
58Chromsome breakage (HP:0040012)2.06523822
59Sensorimotor neuropathy (HP:0007141)2.06271408
60Broad palm (HP:0001169)2.02778696
61High anterior hairline (HP:0009890)2.02327601
62Absent frontal sinuses (HP:0002688)1.97241207
63Abnormality of the femoral head (HP:0003368)1.96897331
64Dislocated radial head (HP:0003083)1.94319581
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92513963
66Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92468870
67Lip pit (HP:0100267)1.88495612
68Bradycardia (HP:0001662)1.86597800
69Flat acetabular roof (HP:0003180)1.86518878
70Abnormality of carpal bone ossification (HP:0006257)1.86299936
71Abnormality of the prostate (HP:0008775)1.86254973
72Arthropathy (HP:0003040)1.85982931
73Colon cancer (HP:0003003)1.84492018
74Abnormal ossification of hand bones (HP:0005921)1.83679960
75Spontaneous hematomas (HP:0007420)1.80989985
76Abnormality of the radial head (HP:0003995)1.80424238
77Nausea (HP:0002018)1.79278955
78Ileus (HP:0002595)1.78109157
79Mediastinal lymphadenopathy (HP:0100721)1.78017221
80Febrile seizures (HP:0002373)1.77424110
81Skull defect (HP:0001362)1.75853816
82Stomach cancer (HP:0012126)1.75222672
83Gastrointestinal infarctions (HP:0005244)1.75085701
84Recurrent abscess formation (HP:0002722)1.73581821
85Abnormality of the labia majora (HP:0012881)1.72857667
86Muscle fiber inclusion bodies (HP:0100299)1.72789665
87Mesomelia (HP:0003027)1.71784712
88Abnormal hand bone ossification (HP:0010660)1.69574509
89Abnormality of the fingertips (HP:0001211)1.69340359
90Neoplasm of the adrenal cortex (HP:0100641)1.68333559
91Midline defect of the nose (HP:0004122)1.66870714
92Abnormality of the preputium (HP:0100587)1.66650871
93Abnormality of the pubic bones (HP:0003172)1.66161287
94Breast aplasia (HP:0100783)1.65934012
95Shallow orbits (HP:0000586)1.65923042
96Tibial bowing (HP:0002982)1.65606301
97Hepatocellular carcinoma (HP:0001402)1.65322590
98Irregular vertebral endplates (HP:0003301)1.64740013
99Gingival bleeding (HP:0000225)1.63688572
100Abnormality of the columella (HP:0009929)1.63474325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L4.46836598
2LATS14.11706637
3LATS23.56157399
4PBK3.32895270
5MAP3K32.97925805
6CDC72.60919145
7CASK2.27409869
8PIM12.16031799
9EIF2AK22.08825668
10MAP2K31.99626984
11INSRR1.87848083
12CAMK1D1.86117395
13NLK1.83955371
14TAOK11.77296475
15PIM21.75767547
16ZAK1.71351338
17ABL21.69973744
18STK381.68540429
19DAPK21.68157949
20IRAK31.64257095
21TSSK61.59869770
22PIK3CG1.47264687
23TGFBR21.33919474
24SGK21.31147294
25NME21.28083282
26GRK11.21310225
27EPHA21.20780102
28AURKB1.18435170
29MAP2K71.17693822
30CDK81.15420023
31GRK71.13546023
32SGK4941.12589696
33SGK2231.12589696
34TNK21.12185383
35TAOK21.10856867
36MAP3K111.10594288
37PKN11.08801038
38PLK11.07164990
39MAPK71.07121934
40CDK60.98700004
41JAK30.96157604
42YES10.95307380
43BMPR1B0.93628079
44MAP3K140.90539483
45MELK0.90234338
46CDK30.85334123
47ERBB40.85069333
48IKBKB0.83174696
49ATR0.77612524
50CHEK20.73819318
51LYN0.73323997
52MAP3K120.73054446
53SGK10.72164657
54MAP2K20.71928004
55TYK20.69783270
56PASK0.68622260
57SGK30.68149288
58DAPK10.67243412
59MAP3K50.67065444
60TRPM70.66574256
61ABL10.64881303
62FRK0.64071870
63CAMK40.63447386
64NEK60.62863215
65CHEK10.61565729
66PDGFRB0.61318271
67STK390.61156603
68AKT10.59134541
69STK40.58373239
70EGFR0.57117246
71STK30.56706526
72NTRK20.56465894
73DDR20.56061362
74CDK190.54798668
75OBSCN0.54639167
76TEC0.54291507
77STK100.52931013
78CLK10.51100220
79PLK20.49981535
80ALK0.49856800
81CDK70.49547705
82CSNK1D0.46576711
83INSR0.46201043
84HCK0.43055660
85TTK0.42658118
86MKNK10.41578237
87ATM0.40973366
88GRK50.40528402
89PLK30.40336032
90IGF1R0.39556852
91JAK10.38904114
92MAPK30.37949232
93OXSR10.37924172
94MAPKAPK20.37502815
95NUAK10.37364471
96CDK20.37236846
97CSNK2A20.35080506
98NEK20.34450293
99TBK10.33894432
100DAPK30.33254726

Predicted pathways (KEGG)

RankGene SetZ-score
1NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54048517
2Adherens junction_Homo sapiens_hsa045202.26301341
3p53 signaling pathway_Homo sapiens_hsa041152.20668851
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.18161506
5Cell cycle_Homo sapiens_hsa041102.17712979
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.14809990
7Protein digestion and absorption_Homo sapiens_hsa049742.14652396
8Small cell lung cancer_Homo sapiens_hsa052222.05311612
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.99836370
10African trypanosomiasis_Homo sapiens_hsa051431.95692308
11Legionellosis_Homo sapiens_hsa051341.89760204
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88227796
13Leishmaniasis_Homo sapiens_hsa051401.82382664
14Allograft rejection_Homo sapiens_hsa053301.81056131
15ECM-receptor interaction_Homo sapiens_hsa045121.79714062
16Viral myocarditis_Homo sapiens_hsa054161.78201547
17Staphylococcus aureus infection_Homo sapiens_hsa051501.76769269
18Malaria_Homo sapiens_hsa051441.74558134
19Sphingolipid metabolism_Homo sapiens_hsa006001.70717431
20TNF signaling pathway_Homo sapiens_hsa046681.66659255
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.59394447
22Inositol phosphate metabolism_Homo sapiens_hsa005621.53299003
23Pertussis_Homo sapiens_hsa051331.50164899
24One carbon pool by folate_Homo sapiens_hsa006701.38323444
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35972918
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35100045
27Lysine degradation_Homo sapiens_hsa003101.28906082
28Apoptosis_Homo sapiens_hsa042101.25119271
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23995240
30Fanconi anemia pathway_Homo sapiens_hsa034601.23129900
31Vitamin B6 metabolism_Homo sapiens_hsa007501.16980225
32Rheumatoid arthritis_Homo sapiens_hsa053231.16910198
33Basal cell carcinoma_Homo sapiens_hsa052171.12440801
34Renin-angiotensin system_Homo sapiens_hsa046141.11916587
35Toxoplasmosis_Homo sapiens_hsa051451.05490829
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04479391
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04393368
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02381664
39Systemic lupus erythematosus_Homo sapiens_hsa053221.02293183
40Influenza A_Homo sapiens_hsa051641.02291421
41Sulfur metabolism_Homo sapiens_hsa009201.01100674
42Type I diabetes mellitus_Homo sapiens_hsa049401.01017394
43Herpes simplex infection_Homo sapiens_hsa051681.00571138
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99137894
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99083546
46Graft-versus-host disease_Homo sapiens_hsa053320.95807098
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95423136
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93171725
49Hematopoietic cell lineage_Homo sapiens_hsa046400.92363830
50Tuberculosis_Homo sapiens_hsa051520.91090383
51Phagosome_Homo sapiens_hsa041450.89329296
52MicroRNAs in cancer_Homo sapiens_hsa052060.89304043
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88982464
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87876193
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86733853
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86319001
57Amoebiasis_Homo sapiens_hsa051460.85440216
58Other glycan degradation_Homo sapiens_hsa005110.82378860
59FoxO signaling pathway_Homo sapiens_hsa040680.81682326
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79654395
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78602277
62Autoimmune thyroid disease_Homo sapiens_hsa053200.76941986
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76138562
64DNA replication_Homo sapiens_hsa030300.75054871
65Asthma_Homo sapiens_hsa053100.74017155
66Hepatitis B_Homo sapiens_hsa051610.73161110
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72702593
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72658493
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72520157
70Bile secretion_Homo sapiens_hsa049760.69541151
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68690807
72RNA degradation_Homo sapiens_hsa030180.68392487
73Homologous recombination_Homo sapiens_hsa034400.68307650
74Tight junction_Homo sapiens_hsa045300.67976041
75Retinol metabolism_Homo sapiens_hsa008300.67751596
76ABC transporters_Homo sapiens_hsa020100.67492497
77Hippo signaling pathway_Homo sapiens_hsa043900.67416041
78Hepatitis C_Homo sapiens_hsa051600.66355524
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66131224
80Arachidonic acid metabolism_Homo sapiens_hsa005900.65967880
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64380998
82Tyrosine metabolism_Homo sapiens_hsa003500.63831322
83Bladder cancer_Homo sapiens_hsa052190.62426640
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.62158479
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60936215
86Pancreatic cancer_Homo sapiens_hsa052120.58327401
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58170736
88Osteoclast differentiation_Homo sapiens_hsa043800.55643958
89Measles_Homo sapiens_hsa051620.55206064
90Notch signaling pathway_Homo sapiens_hsa043300.54206784
91Pathways in cancer_Homo sapiens_hsa052000.52327254
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51984469
93Platelet activation_Homo sapiens_hsa046110.51375841
94Viral carcinogenesis_Homo sapiens_hsa052030.49152563
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46638544
96Colorectal cancer_Homo sapiens_hsa052100.43979976
97Arginine and proline metabolism_Homo sapiens_hsa003300.43709115
98Nicotine addiction_Homo sapiens_hsa050330.43487291
99HTLV-I infection_Homo sapiens_hsa051660.43387973
100Epstein-Barr virus infection_Homo sapiens_hsa051690.43201258

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »