ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of hexokinase activity (GO:1903299)	4.27444699
2	regulation of glucokinase activity (GO:0033131)	4.27444699
3	behavioral response to nicotine (GO:0035095)	4.21322224
4	cellular ketone body metabolic process (GO:0046950)	3.96862891
5	water-soluble vitamin biosynthetic process (GO:0042364)	3.73241006
6	inositol phosphate catabolic process (GO:0071545)	3.70805995
7	DNA deamination (GO:0045006)	3.69151926
8	ketone body metabolic process (GO:1902224)	3.65034628
9	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.41551191
10	respiratory chain complex IV assembly (GO:0008535)	3.35154607
11	axoneme assembly (GO:0035082)	3.33477950
12	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.29208621
13	inositol phosphate dephosphorylation (GO:0046855)	3.29208621
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.28800951
15	actin-myosin filament sliding (GO:0033275)	3.22995633
16	muscle filament sliding (GO:0030049)	3.22995633
17	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.22264956
18	epithelial cilium movement (GO:0003351)	3.15857256
19	regulation of skeletal muscle contraction (GO:0014819)	3.15622238
20	polyol catabolic process (GO:0046174)	3.11864855
21	adaptation of signaling pathway (GO:0023058)	3.08023149
22	cytochrome complex assembly (GO:0017004)	3.05537804
23	platelet dense granule organization (GO:0060155)	3.03809175
24	endocrine pancreas development (GO:0031018)	3.02399899
25	indolalkylamine metabolic process (GO:0006586)	3.01113373
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.00288855
27	detection of light stimulus involved in visual perception (GO:0050908)	2.99089539
28	detection of light stimulus involved in sensory perception (GO:0050962)	2.99089539
29	protein complex biogenesis (GO:0070271)	2.98734617
30	response to muscle activity (GO:0014850)	2.96243713
31	indole-containing compound catabolic process (GO:0042436)	2.95772786
32	indolalkylamine catabolic process (GO:0046218)	2.95772786
33	tryptophan catabolic process (GO:0006569)	2.95772786
34	positive regulation of glycolytic process (GO:0045821)	2.95491644
35	kidney morphogenesis (GO:0060993)	2.93819132
36	nitric oxide mediated signal transduction (GO:0007263)	2.92724369
37	fucose catabolic process (GO:0019317)	2.90198302
38	L-fucose metabolic process (GO:0042354)	2.90198302
39	L-fucose catabolic process (GO:0042355)	2.90198302
40	cornea development in camera-type eye (GO:0061303)	2.89434681
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88013710
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87674069
43	response to pheromone (GO:0019236)	2.86921172
44	regulation of action potential (GO:0098900)	2.85302535
45	amino acid salvage (GO:0043102)	2.85280210
46	L-methionine salvage (GO:0071267)	2.85280210
47	L-methionine biosynthetic process (GO:0071265)	2.85280210
48	cytidine metabolic process (GO:0046087)	2.84447098
49	cytidine catabolic process (GO:0006216)	2.84447098
50	cytidine deamination (GO:0009972)	2.84447098
51	actin-mediated cell contraction (GO:0070252)	2.80013738
52	protein polyglutamylation (GO:0018095)	2.79513955
53	mannosylation (GO:0097502)	2.75975901
54	kynurenine metabolic process (GO:0070189)	2.74955319
55	synaptic transmission, cholinergic (GO:0007271)	2.73007648
56	insulin secretion (GO:0030073)	2.72561159
57	auditory receptor cell stereocilium organization (GO:0060088)	2.72032279
58	regulation of relaxation of muscle (GO:1901077)	2.71403354
59	piRNA metabolic process (GO:0034587)	2.70948052
60	regulation of cilium movement (GO:0003352)	2.68375735
61	ubiquinone biosynthetic process (GO:0006744)	2.68190383
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66231476
63	coenzyme catabolic process (GO:0009109)	2.64589490
64	signal peptide processing (GO:0006465)	2.61777409
65	glycerophospholipid catabolic process (GO:0046475)	2.59744019
66	tryptophan metabolic process (GO:0006568)	2.59155023
67	neuronal action potential (GO:0019228)	2.58091213
68	myofibril assembly (GO:0030239)	2.57556727
69	proline transport (GO:0015824)	2.57437743
70	dopamine transport (GO:0015872)	2.56721542
71	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.56081271
72	ADP metabolic process (GO:0046031)	2.55977421
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55160587
74	NADH dehydrogenase complex assembly (GO:0010257)	2.55160587
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55160587
76	cilium movement (GO:0003341)	2.54485218
77	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.49600270
78	negative regulation of telomere maintenance (GO:0032205)	2.48709227
79	alanine transport (GO:0032328)	2.48355229
80	skeletal muscle contraction (GO:0003009)	2.48324106
81	reflex (GO:0060004)	2.47919658
82	S-adenosylmethionine metabolic process (GO:0046500)	2.47544983
83	lactate metabolic process (GO:0006089)	2.46184180
84	ubiquinone metabolic process (GO:0006743)	2.45988021
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45963587
86	positive regulation of meiosis (GO:0045836)	2.44918675
87	neuron fate determination (GO:0048664)	2.43754270
88	adult feeding behavior (GO:0008343)	2.42395197
89	cilium morphogenesis (GO:0060271)	2.42167496
90	establishment of protein localization to Golgi (GO:0072600)	2.41362757
91	nucleobase catabolic process (GO:0046113)	2.39757033
92	dentate gyrus development (GO:0021542)	2.39597089
93	nonmotile primary cilium assembly (GO:0035058)	2.35994919
94	indole-containing compound metabolic process (GO:0042430)	2.35969835
95	cilium organization (GO:0044782)	2.34022636
96	peptidyl-histidine modification (GO:0018202)	2.32988762
97	protein localization to Golgi apparatus (GO:0034067)	2.30266678
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.29911525
99	methionine biosynthetic process (GO:0009086)	2.29070565
100	spinal cord motor neuron differentiation (GO:0021522)	2.29051476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41247505
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.29128193
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.22983950
4	VDR_22108803_ChIP-Seq_LS180_Human	3.05615634
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.90062588
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73340643
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58883738
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53923113
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35302813
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33336490
11	FUS_26573619_Chip-Seq_HEK293_Human	2.14921811
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13936518
13	P300_19829295_ChIP-Seq_ESCs_Human	2.00968522
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98065153
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.95863381
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91522027
17	EWS_26573619_Chip-Seq_HEK293_Human	1.75724764
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.73397111
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.73211258
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71589084
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.70756847
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70019845
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.68454433
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59206451
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56727382
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54917595
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54797240
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.54797240
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53102622
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.52674967
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50311717
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.49835760
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.48881041
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48765739
35	AR_25329375_ChIP-Seq_VCAP_Human	1.47693364
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45554612
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44466842
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44446875
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44446875
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44379776
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43124718
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41712264
43	STAT3_23295773_ChIP-Seq_U87_Human	1.41535905
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41329109
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41034725
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41027725
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40874294
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39997254
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38973766
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38171610
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36953026
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35317661
53	TCF4_23295773_ChIP-Seq_U87_Human	1.34392915
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30944841
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30130268
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29860231
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28803703
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26676571
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25235247
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25235247
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25148833
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.25003999
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24131668
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23094787
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21648914
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21563463
67	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.19264479
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18483606
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18370470
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18199087
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18129878
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18096445
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18054827
74	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15687491
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15599846
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14075171
77	NCOR_22424771_ChIP-Seq_293T_Human	1.13946278
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13762404
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13544692
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13544692
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.13127641
82	AR_20517297_ChIP-Seq_VCAP_Human	1.12690541
83	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12600327
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12350694
85	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11655475
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10982244
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09181289
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08613775
89	MYC_18940864_ChIP-ChIP_HL60_Human	1.08252903
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08062963
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07753351
92	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05092772
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04248854
94	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03934917
95	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03504371
96	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03184521
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02907651
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02733069
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02136959
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00942186

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.57230709
2	MP0003195_calcinosis	3.13096545
3	MP0004145_abnormal_muscle_electrophysio	3.04951710
4	MP0008877_abnormal_DNA_methylation	2.98136042
5	MP0003646_muscle_fatigue	2.97875508
6	MP0002102_abnormal_ear_morphology	2.56023633
7	MP0000749_muscle_degeneration	2.37056219
8	MP0006072_abnormal_retinal_apoptosis	2.31766258
9	MP0000372_irregular_coat_pigmentation	2.28646725
10	MP0005551_abnormal_eye_electrophysiolog	2.06242137
11	MP0003787_abnormal_imprinting	1.98687577
12	MP0009780_abnormal_chondrocyte_physiolo	1.90900578
13	MP0002638_abnormal_pupillary_reflex	1.90565646
14	MP0009046_muscle_twitch	1.89168592
15	MP0000569_abnormal_digit_pigmentation	1.87588950
16	MP0002876_abnormal_thyroid_physiology	1.87095330
17	MP0003011_delayed_dark_adaptation	1.87046884
18	MP0005645_abnormal_hypothalamus_physiol	1.83393540
19	MP0001984_abnormal_olfaction	1.79897624
20	MP0005253_abnormal_eye_physiology	1.78259121
21	MP0005379_endocrine/exocrine_gland_phen	1.75594923
22	MP0005646_abnormal_pituitary_gland	1.74212750
23	MP0006036_abnormal_mitochondrial_physio	1.72839460
24	MP0000013_abnormal_adipose_tissue	1.69681452
25	MP0008872_abnormal_physiological_respon	1.68181145
26	MP0001986_abnormal_taste_sensitivity	1.66638069
27	MP0004215_abnormal_myocardial_fiber	1.63039846
28	MP0002163_abnormal_gland_morphology	1.56258107
29	MP0003806_abnormal_nucleotide_metabolis	1.55543268
30	MP0001501_abnormal_sleep_pattern	1.54666619
31	MP0002909_abnormal_adrenal_gland	1.53571806
32	MP0004043_abnormal_pH_regulation	1.50700309
33	MP0004142_abnormal_muscle_tone	1.49200485
34	MP0002272_abnormal_nervous_system	1.49185476
35	MP0009745_abnormal_behavioral_response	1.48390576
36	MP0001968_abnormal_touch/_nociception	1.47692835
37	MP0002693_abnormal_pancreas_physiology	1.47160563
38	MP0003283_abnormal_digestive_organ	1.42359631
39	MP0008875_abnormal_xenobiotic_pharmacok	1.40924629
40	MP0002160_abnormal_reproductive_system	1.40022919
41	MP0004084_abnormal_cardiac_muscle	1.35791626
42	MP0001944_abnormal_pancreas_morphology	1.34942138
43	MP0000427_abnormal_hair_cycle	1.34819826
44	MP0004885_abnormal_endolymph	1.34003652
45	MP0004036_abnormal_muscle_relaxation	1.31988763
46	MP0004147_increased_porphyrin_level	1.30210913
47	MP0000631_abnormal_neuroendocrine_gland	1.29301738
48	MP0004270_analgesia	1.28339672
49	MP0002938_white_spotting	1.26990403
50	MP0001486_abnormal_startle_reflex	1.25706201
51	MP0006276_abnormal_autonomic_nervous	1.23719821
52	MP0006292_abnormal_olfactory_placode	1.21900827
53	MP0010386_abnormal_urinary_bladder	1.20204235
54	MP0005389_reproductive_system_phenotype	1.18013221
55	MP0005620_abnormal_muscle_contractility	1.16722989
56	MP0004133_heterotaxia	1.16695392
57	MP0001529_abnormal_vocalization	1.15607165
58	MP0003880_abnormal_central_pattern	1.12191253
59	MP0002064_seizures	1.12170820
60	MP0003122_maternal_imprinting	1.09953652
61	MP0002269_muscular_atrophy	1.07545371
62	MP0004924_abnormal_behavior	1.07020791
63	MP0005386_behavior/neurological_phenoty	1.07020791
64	MP0001905_abnormal_dopamine_level	1.05936589
65	MP0002106_abnormal_muscle_physiology	1.04771201
66	MP0002572_abnormal_emotion/affect_behav	1.04598034
67	MP0001485_abnormal_pinna_reflex	1.04445323
68	MP0004484_altered_response_of	1.04008225
69	MP0005332_abnormal_amino_acid	1.02241096
70	MP0002277_abnormal_respiratory_mucosa	1.01778388
71	MP0005174_abnormal_tail_pigmentation	1.01667343
72	MP0002736_abnormal_nociception_after	1.00727854
73	MP0005369_muscle_phenotype	0.99391218
74	MP0002557_abnormal_social/conspecific_i	0.98102418
75	MP0005084_abnormal_gallbladder_morpholo	0.98036573
76	MP0008775_abnormal_heart_ventricle	0.96310579
77	MP0002078_abnormal_glucose_homeostasis	0.96010248
78	MP0003137_abnormal_impulse_conducting	0.95580376
79	MP0003136_yellow_coat_color	0.94609164
80	MP0002928_abnormal_bile_duct	0.94285429
81	MP0005220_abnormal_exocrine_pancreas	0.93205824
82	MP0002734_abnormal_mechanical_nocicepti	0.92315062
83	MP0005266_abnormal_metabolism	0.92123908
84	MP0001919_abnormal_reproductive_system	0.90080190
85	MP0002653_abnormal_ependyma_morphology	0.89983272
86	MP0002067_abnormal_sensory_capabilities	0.88980560
87	MP0003121_genomic_imprinting	0.87837656
88	MP0004085_abnormal_heartbeat	0.86444175
89	MP0005330_cardiomyopathy	0.86341212
90	MP0005075_abnormal_melanosome_morpholog	0.85712520
91	MP0001970_abnormal_pain_threshold	0.84398775
92	MP0001756_abnormal_urination	0.81310428
93	MP0000230_abnormal_systemic_arterial	0.81210470
94	MP0002822_catalepsy	0.81196467
95	MP0005636_abnormal_mineral_homeostasis	0.79445717
96	MP0002234_abnormal_pharynx_morphology	0.79350471
97	MP0002229_neurodegeneration	0.78181271
98	MP0001764_abnormal_homeostasis	0.75172632
99	MP0005448_abnormal_energy_balance	0.75047596
100	MP0002108_abnormal_muscle_morphology	0.73327467

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Calf muscle hypertrophy (HP:0008981)	3.92969203
2	Muscle hypertrophy of the lower extremities (HP:0008968)	3.82720329
3	Pancreatic cysts (HP:0001737)	3.76340406
4	Muscle fiber inclusion bodies (HP:0100299)	3.38234974
5	Pancreatic fibrosis (HP:0100732)	3.36904761
6	Ketoacidosis (HP:0001993)	3.33959660
7	Type II lissencephaly (HP:0007260)	3.32621174
8	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.26776656
9	Congenital stationary night blindness (HP:0007642)	3.24975409
10	Molar tooth sign on MRI (HP:0002419)	3.12125280
11	Abnormality of midbrain morphology (HP:0002418)	3.12125280
12	True hermaphroditism (HP:0010459)	3.10078043
13	Hypothermia (HP:0002045)	2.96287816
14	Nephronophthisis (HP:0000090)	2.93063259
15	Hyperinsulinemic hypoglycemia (HP:0000825)	2.92533102
16	Nemaline bodies (HP:0003798)	2.85959732
17	Ketosis (HP:0001946)	2.82979858
18	Abnormality of the renal cortex (HP:0011035)	2.80275602
19	Medial flaring of the eyebrow (HP:0010747)	2.74120092
20	Progressive macrocephaly (HP:0004481)	2.70612432
21	Acute necrotizing encephalopathy (HP:0006965)	2.69462018
22	Exercise-induced muscle cramps (HP:0003710)	2.68363911
23	Methylmalonic acidemia (HP:0002912)	2.68077428
24	Hyperventilation (HP:0002883)	2.66832175
25	Hypoglycemic coma (HP:0001325)	2.60578107
26	Distal arthrogryposis (HP:0005684)	2.57021346
27	Large for gestational age (HP:0001520)	2.56869560
28	Rimmed vacuoles (HP:0003805)	2.50446590
29	Abnormality of the renal medulla (HP:0100957)	2.48640828
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.48108201
31	Abnormality of the calf musculature (HP:0001430)	2.47129644
32	Renal cortical cysts (HP:0000803)	2.46895645
33	Attenuation of retinal blood vessels (HP:0007843)	2.46452953
34	Mitochondrial inheritance (HP:0001427)	2.42923542
35	Polydipsia (HP:0001959)	2.42335710
36	Abnormal drinking behavior (HP:0030082)	2.42335710
37	Hyperglycemia (HP:0003074)	2.36433100
38	Hepatic necrosis (HP:0002605)	2.31165850
39	Hypomagnesemia (HP:0002917)	2.28368245
40	Broad-based gait (HP:0002136)	2.28248847
41	Increased CSF lactate (HP:0002490)	2.28181627
42	Hypoglycemic seizures (HP:0002173)	2.27611996
43	Acute encephalopathy (HP:0006846)	2.27544621
44	Hemiparesis (HP:0001269)	2.23813040
45	Clumsiness (HP:0002312)	2.23435620
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22372807
47	Type 2 muscle fiber atrophy (HP:0003554)	2.22337584
48	Gaze-evoked nystagmus (HP:0000640)	2.18793862
49	Methylmalonic aciduria (HP:0012120)	2.16813736
50	Cystic liver disease (HP:0006706)	2.15183264
51	Abolished electroretinogram (ERG) (HP:0000550)	2.14791433
52	Intestinal atresia (HP:0011100)	2.12454930
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11211310
54	Abnormality of alanine metabolism (HP:0010916)	2.11211310
55	Hyperalaninemia (HP:0003348)	2.11211310
56	Inability to walk (HP:0002540)	2.10990410
57	Tubular atrophy (HP:0000092)	2.08306575
58	Exercise-induced myalgia (HP:0003738)	2.06215702
59	Abnormality of vitamin B metabolism (HP:0004340)	2.04814018
60	Gait imbalance (HP:0002141)	2.04648198
61	Hypoplasia of the fovea (HP:0007750)	2.02313544
62	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.02313544
63	Congenital primary aphakia (HP:0007707)	2.00618766
64	Hepatocellular necrosis (HP:0001404)	2.00550119
65	Lipid accumulation in hepatocytes (HP:0006561)	1.99245238
66	Fetal akinesia sequence (HP:0001989)	1.98179292
67	Pendular nystagmus (HP:0012043)	1.97787618
68	Increased corneal curvature (HP:0100692)	1.97035749
69	Keratoconus (HP:0000563)	1.97035749
70	Chronic hepatic failure (HP:0100626)	1.96863731
71	Furrowed tongue (HP:0000221)	1.96461906
72	EMG: myopathic abnormalities (HP:0003458)	1.95780363
73	Cerebellar dysplasia (HP:0007033)	1.95619409
74	Hyporeflexia of lower limbs (HP:0002600)	1.95243223
75	Abnormality of endocrine pancreas physiology (HP:0012093)	1.92210624
76	Abnormality of the pancreatic islet cells (HP:0006476)	1.92210624
77	Polyuria (HP:0000103)	1.86941133
78	Febrile seizures (HP:0002373)	1.86917731
79	Focal motor seizures (HP:0011153)	1.85490251
80	Decreased central vision (HP:0007663)	1.85082263
81	Sclerocornea (HP:0000647)	1.84081461
82	Optic disc pallor (HP:0000543)	1.83340632
83	Myoglobinuria (HP:0002913)	1.82693102
84	Absent speech (HP:0001344)	1.81974827
85	Progressive inability to walk (HP:0002505)	1.81799697
86	Abnormality of the labia minora (HP:0012880)	1.81673772
87	Absent phalangeal crease (HP:0006109)	1.79084307
88	Nephrogenic diabetes insipidus (HP:0009806)	1.77810641
89	Absent/shortened dynein arms (HP:0200106)	1.77641959
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.77641959
91	Retinal dysplasia (HP:0007973)	1.75390244
92	Popliteal pterygium (HP:0009756)	1.74596795
93	Dialeptic seizures (HP:0011146)	1.73802672
94	Male pseudohermaphroditism (HP:0000037)	1.71486479
95	Thyroiditis (HP:0100646)	1.71337370
96	Congenital hepatic fibrosis (HP:0002612)	1.69899601
97	Optic nerve hypoplasia (HP:0000609)	1.69762792
98	Frequent falls (HP:0002359)	1.69716084
99	Abnormality of the fovea (HP:0000493)	1.68974413
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68854855

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.05537397
2	PINK1	4.62026638
3	OBSCN	4.17647023
4	MAP4K2	2.97903541
5	PHKG2	2.85441787
6	PHKG1	2.85441787
7	GRK1	2.34446060
8	ADRBK2	2.31335856
9	BMPR1B	2.26776617
10	WNK3	2.16449652
11	INSRR	2.02954944
12	FGFR2	1.82513242
13	ZAK	1.73599243
14	NUAK1	1.69345821
15	ACVR1B	1.62007154
16	WNK4	1.59112669
17	MAPK13	1.51691728
18	DAPK2	1.50937340
19	CASK	1.49577321
20	TAOK3	1.47568873
21	MAP3K4	1.46501547
22	MUSK	1.33045464
23	OXSR1	1.21919741
24	TLK1	1.19873444
25	BCKDK	1.15473032
26	TXK	1.14611335
27	STK39	1.10033021
28	MAPKAPK3	1.09646487
29	TIE1	1.08065012
30	PAK3	1.06387494
31	CSNK1G1	1.04193743
32	CAMKK2	0.99277957
33	TRIM28	0.98916474
34	MAP2K6	0.98500779
35	ERBB3	0.97962931
36	MST4	0.97521642
37	MARK1	0.96811578
38	MAP2K7	0.95275419
39	EIF2AK3	0.94937145
40	STK38L	0.91688206
41	BRSK2	0.91394726
42	CSNK1G2	0.91258506
43	PRKCE	0.90943077
44	CSNK1G3	0.90813077
45	PLK2	0.88491148
46	NME1	0.81800532
47	CCNB1	0.80537512
48	PNCK	0.77843672
49	PRKCG	0.77218509
50	ADRBK1	0.77079388
51	DYRK2	0.74182310
52	TRPM7	0.71054504
53	TNIK	0.70653211
54	PIK3CG	0.70467018
55	NLK	0.69419945
56	CSNK1A1L	0.67326366
57	MKNK2	0.64761551
58	NTRK3	0.64423744
59	EPHA3	0.62916022
60	TNK2	0.61232222
61	CAMK2A	0.59070606
62	STK3	0.58910080
63	WEE1	0.57481452
64	LIMK1	0.57131713
65	CAMK2D	0.56589991
66	PRKAA2	0.56027632
67	PRKAA1	0.55742585
68	PTK2B	0.55516161
69	FER	0.54169054
70	PRKG1	0.53947940
71	PRKACA	0.52952350
72	PASK	0.51414011
73	VRK1	0.51222071
74	MARK3	0.51104103
75	CSNK1A1	0.49794980
76	IRAK1	0.47877983
77	CAMK1	0.47620132
78	SGK2	0.46927861
79	PIK3CA	0.46097999
80	PRKCQ	0.45219423
81	STK11	0.44884612
82	MAP2K4	0.44346773
83	IKBKB	0.41066781
84	PLK3	0.39798022
85	MAP3K7	0.39793358
86	CDK3	0.39785982
87	RPS6KA5	0.38437175
88	TGFBR1	0.37907428
89	GRK7	0.35303010
90	CSNK1D	0.34636300
91	ROCK1	0.33027375
92	PKN1	0.31950315
93	RPS6KB1	0.31926180
94	GRK5	0.31887888
95	PRKACB	0.30913084
96	PRKCA	0.30527323
97	PRKCI	0.27910521
98	HIPK2	0.27871421
99	BCR	0.26992147
100	NTRK2	0.25818023

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.42963793
2	Butanoate metabolism_Homo sapiens_hsa00650	2.74317680
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62876084
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50998236
5	Phototransduction_Homo sapiens_hsa04744	2.49090518
6	Protein export_Homo sapiens_hsa03060	2.32037529
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27827048
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.22525812
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.11202635
10	Parkinsons disease_Homo sapiens_hsa05012	2.01169841
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.97904394
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92696359
13	Propanoate metabolism_Homo sapiens_hsa00640	1.89914496
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87041447
15	Regulation of autophagy_Homo sapiens_hsa04140	1.84840535
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83753027
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82094752
18	Insulin secretion_Homo sapiens_hsa04911	1.77107766
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74515536
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.70622692
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62864000
22	Caffeine metabolism_Homo sapiens_hsa00232	1.49372308
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43611738
24	Alzheimers disease_Homo sapiens_hsa05010	1.43018803
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.39880136
26	Peroxisome_Homo sapiens_hsa04146	1.39478797
27	Circadian rhythm_Homo sapiens_hsa04710	1.39281238
28	RNA polymerase_Homo sapiens_hsa03020	1.38008023
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34466832
30	Nicotine addiction_Homo sapiens_hsa05033	1.25256472
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22031606
32	Olfactory transduction_Homo sapiens_hsa04740	1.20762157
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18287719
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.17838199
35	Sulfur metabolism_Homo sapiens_hsa00920	1.15609580
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14443639
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12089898
38	Huntingtons disease_Homo sapiens_hsa05016	1.11144471
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09759903
40	Basal transcription factors_Homo sapiens_hsa03022	1.08516480
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07610248
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05812813
43	RNA degradation_Homo sapiens_hsa03018	1.02366305
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01833913
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98773798
46	Taste transduction_Homo sapiens_hsa04742	0.98578311
47	Homologous recombination_Homo sapiens_hsa03440	0.98438538
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97551111
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97074928
50	Mineral absorption_Homo sapiens_hsa04978	0.94468422
51	Circadian entrainment_Homo sapiens_hsa04713	0.93727169
52	Fatty acid degradation_Homo sapiens_hsa00071	0.90753482
53	Purine metabolism_Homo sapiens_hsa00230	0.87431209
54	Retinol metabolism_Homo sapiens_hsa00830	0.83884609
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83310486
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82899536
57	Fatty acid elongation_Homo sapiens_hsa00062	0.81954357
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81362512
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80657736
60	ABC transporters_Homo sapiens_hsa02010	0.80326191
61	GABAergic synapse_Homo sapiens_hsa04727	0.78663720
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.78444925
63	Salivary secretion_Homo sapiens_hsa04970	0.78394602
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76202609
65	Serotonergic synapse_Homo sapiens_hsa04726	0.73626548
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.73304190
67	Morphine addiction_Homo sapiens_hsa05032	0.72947895
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.72319426
69	Metabolic pathways_Homo sapiens_hsa01100	0.72276469
70	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.72127612
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72077533
72	Renin secretion_Homo sapiens_hsa04924	0.65872756
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.64728855
74	Folate biosynthesis_Homo sapiens_hsa00790	0.60249371
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.60218772
76	One carbon pool by folate_Homo sapiens_hsa00670	0.59609017
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58930189
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57474123
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57250349
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56370673
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56298578
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54392379
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53567396
84	Amphetamine addiction_Homo sapiens_hsa05031	0.52846256
85	Proteasome_Homo sapiens_hsa03050	0.52309346
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49903175
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49134653
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.48818079
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46088918
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44766603
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44613165
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43712875
93	Glutathione metabolism_Homo sapiens_hsa00480	0.42593248
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.41290655
95	Histidine metabolism_Homo sapiens_hsa00340	0.39749835
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38872001
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.38444533
98	Long-term depression_Homo sapiens_hsa04730	0.37871618
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37723898
100	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37471233

MRLN

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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