MRM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.99639280
2DNA strand elongation involved in DNA replication (GO:0006271)4.61174029
3telomere maintenance via semi-conservative replication (GO:0032201)4.49863013
4establishment of integrated proviral latency (GO:0075713)4.46368131
5DNA strand elongation (GO:0022616)4.45487021
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39479231
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24485421
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.19938528
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.17621436
10ribosome assembly (GO:0042255)4.16321872
11DNA replication checkpoint (GO:0000076)4.15208014
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.08873876
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.07817508
14negative regulation of ligase activity (GO:0051352)4.02512108
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.02512108
16regulation of cellular amino acid metabolic process (GO:0006521)3.84945940
17CENP-A containing nucleosome assembly (GO:0034080)3.78841783
18telomere maintenance via recombination (GO:0000722)3.78714779
19chromatin remodeling at centromere (GO:0031055)3.75003219
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72077653
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70271256
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70271256
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70271256
24pseudouridine synthesis (GO:0001522)3.70037493
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68696052
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68696052
27establishment of viral latency (GO:0019043)3.64535242
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63395881
29mitotic metaphase plate congression (GO:0007080)3.62770333
30chaperone-mediated protein transport (GO:0072321)3.61907167
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61204769
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.61204769
33regulation of mitochondrial translation (GO:0070129)3.60512137
34rRNA modification (GO:0000154)3.59297700
35mitotic recombination (GO:0006312)3.58129253
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.55776372
37IMP biosynthetic process (GO:0006188)3.55059357
38protein localization to kinetochore (GO:0034501)3.55005402
39ATP synthesis coupled proton transport (GO:0015986)3.52632650
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52632650
41spliceosomal snRNP assembly (GO:0000387)3.50292778
42maturation of 5.8S rRNA (GO:0000460)3.49356227
43telomere maintenance via telomere lengthening (GO:0010833)3.46208593
44positive regulation of ligase activity (GO:0051351)3.45684898
45formation of translation preinitiation complex (GO:0001731)3.41904691
46purine nucleobase biosynthetic process (GO:0009113)3.39303414
47protein targeting to mitochondrion (GO:0006626)3.37229371
48DNA catabolic process, exonucleolytic (GO:0000738)3.36851638
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.34814181
50ribosome biogenesis (GO:0042254)3.33031716
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.32876850
52DNA replication initiation (GO:0006270)3.31223720
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29708950
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.29708950
55tRNA aminoacylation for protein translation (GO:0006418)3.29446929
56ribosomal large subunit biogenesis (GO:0042273)3.29130838
57transcription-coupled nucleotide-excision repair (GO:0006283)3.28928039
58amino acid activation (GO:0043038)3.28413338
59tRNA aminoacylation (GO:0043039)3.28413338
60nucleobase biosynthetic process (GO:0046112)3.27488907
61DNA damage response, detection of DNA damage (GO:0042769)3.26894917
62DNA ligation (GO:0006266)3.26644630
63rRNA processing (GO:0006364)3.25481224
64cell cycle G1/S phase transition (GO:0044843)3.23876495
65G1/S transition of mitotic cell cycle (GO:0000082)3.23876495
66DNA replication-dependent nucleosome organization (GO:0034723)3.22597320
67DNA replication-dependent nucleosome assembly (GO:0006335)3.22597320
68mitochondrial RNA metabolic process (GO:0000959)3.21847111
69DNA unwinding involved in DNA replication (GO:0006268)3.21402479
70protein localization to chromosome, centromeric region (GO:0071459)3.19995640
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.19722372
72termination of RNA polymerase III transcription (GO:0006386)3.19722372
73regulation of ligase activity (GO:0051340)3.19240362
74ribonucleoprotein complex biogenesis (GO:0022613)3.18643866
75DNA double-strand break processing (GO:0000729)3.18197122
76transcription from mitochondrial promoter (GO:0006390)3.17340645
77metaphase plate congression (GO:0051310)3.16785080
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16331591
79maturation of SSU-rRNA (GO:0030490)3.13036733
80histone exchange (GO:0043486)3.12898587
81cullin deneddylation (GO:0010388)3.12068862
82peptidyl-histidine modification (GO:0018202)3.11199656
83DNA replication-independent nucleosome assembly (GO:0006336)3.10286838
84DNA replication-independent nucleosome organization (GO:0034724)3.10286838
85rRNA metabolic process (GO:0016072)3.10069179
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09819040
87establishment of protein localization to mitochondrion (GO:0072655)3.08768900
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08273766
89protein deneddylation (GO:0000338)3.07080561
90protein localization to mitochondrion (GO:0070585)3.06776139
91replication fork processing (GO:0031297)3.03631557
92IMP metabolic process (GO:0046040)3.03039623
93mitotic sister chromatid segregation (GO:0000070)3.01014611
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99262748
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99262748
96cellular component biogenesis (GO:0044085)2.97609723
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97474474
98regulation of helicase activity (GO:0051095)2.97074921
99kinetochore organization (GO:0051383)2.96491796
100rRNA methylation (GO:0031167)2.96257914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81852672
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.09992347
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.13430705
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.00263191
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.80064341
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75636058
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59929414
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45016109
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43269805
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.34093152
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.27440812
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08066691
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03762536
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99531155
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94619406
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89872606
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.74918333
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67724794
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59944639
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55284831
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51376122
22DCP1A_22483619_ChIP-Seq_HELA_Human2.51195335
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49993738
24VDR_23849224_ChIP-Seq_CD4+_Human2.46030356
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42089983
26FOXP3_21729870_ChIP-Seq_TREG_Human2.38172030
27XRN2_22483619_ChIP-Seq_HELA_Human2.38112622
28ELK1_19687146_ChIP-ChIP_HELA_Human2.32211949
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26174213
30GABP_19822575_ChIP-Seq_HepG2_Human2.21322880
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19424713
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12675760
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.12416301
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09214234
35TTF2_22483619_ChIP-Seq_HELA_Human2.08260993
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98401463
37AR_21909140_ChIP-Seq_LNCAP_Human1.94327085
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93779412
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.93287302
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91975665
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91029690
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89450299
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87531993
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.83955312
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83793159
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78630193
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74622512
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66252746
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64694817
50KDM5A_27292631_Chip-Seq_BREAST_Human1.63677748
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52409739
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49644416
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48796732
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47805972
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42667856
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.33530805
57MYC_18940864_ChIP-ChIP_HL60_Human1.32632330
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30933178
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30900519
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30521001
61CIITA_25753668_ChIP-Seq_RAJI_Human1.26256658
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25707567
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24961178
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24430534
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20731732
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20355298
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13869362
68TFEB_21752829_ChIP-Seq_HELA_Human1.07668988
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07012197
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06619719
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.05084324
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00824365
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00794857
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99037702
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98790693
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97635590
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96596164
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93938058
79KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93847222
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91940550
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.87849599
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86306878
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86003829
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.83253883
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81010342
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80711840
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80418104
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.79644809
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79019337
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75770380
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75602348
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74683929
93FOXP1_21924763_ChIP-Seq_HESCs_Human0.72335567
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71932245
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71520792
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71154972
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69398500
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69042856
99ELF5_23300383_ChIP-Seq_T47D_Human0.68252137
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66998751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.21149176
2MP0003693_abnormal_embryo_hatching5.10236940
3MP0008058_abnormal_DNA_repair5.00386988
4MP0003111_abnormal_nucleus_morphology4.62071824
5MP0004957_abnormal_blastocyst_morpholog4.34001352
6MP0003806_abnormal_nucleotide_metabolis3.87757054
7MP0003077_abnormal_cell_cycle3.76238907
8MP0008007_abnormal_cellular_replicative3.28313706
9MP0008932_abnormal_embryonic_tissue3.20229750
10MP0003718_maternal_effect2.94472654
11MP0003186_abnormal_redox_activity2.45953843
12MP0006035_abnormal_mitochondrial_morpho2.42096564
13MP0008057_abnormal_DNA_replication2.41706366
14MP0006036_abnormal_mitochondrial_physio2.34163110
15MP0003786_premature_aging2.28432586
16MP0009697_abnormal_copulation2.05906982
17MP0000350_abnormal_cell_proliferation1.84912407
18MP0008877_abnormal_DNA_methylation1.82065611
19MP0001730_embryonic_growth_arrest1.81399582
20MP0003941_abnormal_skin_development1.80969157
21MP0002102_abnormal_ear_morphology1.76654870
22MP0006292_abnormal_olfactory_placode1.71174555
23MP0001529_abnormal_vocalization1.60860271
24MP0000358_abnormal_cell_content/1.60630922
25MP0008789_abnormal_olfactory_epithelium1.55343668
26MP0001697_abnormal_embryo_size1.51253208
27MP0000313_abnormal_cell_death1.49269653
28MP0000372_irregular_coat_pigmentation1.44601481
29MP0005075_abnormal_melanosome_morpholog1.40155927
30MP0002080_prenatal_lethality1.38528607
31MP0001672_abnormal_embryogenesis/_devel1.34107276
32MP0005380_embryogenesis_phenotype1.34107276
33MP0001764_abnormal_homeostasis1.23534147
34MP0005408_hypopigmentation1.19407489
35MP0002019_abnormal_tumor_incidence1.18621546
36MP0005501_abnormal_skin_physiology1.18143643
37MP0002210_abnormal_sex_determination1.16635054
38MP0002160_abnormal_reproductive_system1.15166639
39MP0005499_abnormal_olfactory_system1.15144692
40MP0005394_taste/olfaction_phenotype1.15144692
41MP0001293_anophthalmia1.14858606
42MP0001853_heart_inflammation1.14456004
43MP0001929_abnormal_gametogenesis1.12389420
44MP0001727_abnormal_embryo_implantation1.11424128
45MP0002938_white_spotting1.11153831
46MP0002085_abnormal_embryonic_tissue1.10357397
47MP0003984_embryonic_growth_retardation1.09616830
48MP0003315_abnormal_perineum_morphology1.08592084
49MP0002088_abnormal_embryonic_growth/wei1.06030202
50MP0001145_abnormal_male_reproductive1.01274120
51MP0009672_abnormal_birth_weight1.00432864
52MP0005389_reproductive_system_phenotype0.98890877
53MP0000516_abnormal_urinary_system0.98738333
54MP0005367_renal/urinary_system_phenotyp0.98738333
55MP0002084_abnormal_developmental_patter0.97206116
56MP0001919_abnormal_reproductive_system0.95288772
57MP0010307_abnormal_tumor_latency0.94619565
58MP0000653_abnormal_sex_gland0.92843374
59MP0002163_abnormal_gland_morphology0.92717633
60MP0008875_abnormal_xenobiotic_pharmacok0.89217040
61MP0005084_abnormal_gallbladder_morpholo0.88166569
62MP0010030_abnormal_orbit_morphology0.87596037
63MP0000490_abnormal_crypts_of0.86214088
64MP0003937_abnormal_limbs/digits/tail_de0.83441223
65MP0004147_increased_porphyrin_level0.82425964
66MP0000647_abnormal_sebaceous_gland0.81489210
67MP0002396_abnormal_hematopoietic_system0.80094560
68MP0008995_early_reproductive_senescence0.78026663
69MP0002751_abnormal_autonomic_nervous0.75752014
70MP0002736_abnormal_nociception_after0.75256865
71MP0006072_abnormal_retinal_apoptosis0.74926787
72MP0001119_abnormal_female_reproductive0.73298186
73MP0009333_abnormal_splenocyte_physiolog0.73183898
74MP0001881_abnormal_mammary_gland0.72621495
75MP0003567_abnormal_fetal_cardiomyocyte0.72485527
76MP0009379_abnormal_foot_pigmentation0.72066987
77MP0005395_other_phenotype0.70152628
78MP0005384_cellular_phenotype0.69719431
79MP0003011_delayed_dark_adaptation0.69177817
80MP0003221_abnormal_cardiomyocyte_apopto0.68812687
81MP0002086_abnormal_extraembryonic_tissu0.68739483
82MP0002111_abnormal_tail_morphology0.68700266
83MP0001346_abnormal_lacrimal_gland0.67669180
84MP0004233_abnormal_muscle_weight0.66535004
85MP0003890_abnormal_embryonic-extraembry0.65700515
86MP0002090_abnormal_vision0.63800045
87MP0004197_abnormal_fetal_growth/weight/0.63385236
88MP0005379_endocrine/exocrine_gland_phen0.60901342
89MP0002796_impaired_skin_barrier0.60528409
90MP0005410_abnormal_fertilization0.60430514
91MP0008872_abnormal_physiological_respon0.58565113
92MP0003698_abnormal_male_reproductive0.57454437
93MP0001186_pigmentation_phenotype0.55776632
94MP0001286_abnormal_eye_development0.55597522
95MP0002161_abnormal_fertility/fecundity0.54090760
96MP0002233_abnormal_nose_morphology0.54020983
97MP0001661_extended_life_span0.52993965
98MP0005332_abnormal_amino_acid0.52334494
99MP0008873_increased_physiological_sensi0.51944342
100MP0002095_abnormal_skin_pigmentation0.51776365

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.44003301
2Abnormal mitochondria in muscle tissue (HP:0008316)4.27451961
3Acute encephalopathy (HP:0006846)4.26093500
4Increased CSF lactate (HP:0002490)3.91642722
5Mitochondrial inheritance (HP:0001427)3.84019171
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83564890
7Microvesicular hepatic steatosis (HP:0001414)3.80189632
8Chromsome breakage (HP:0040012)3.61047235
9Increased hepatocellular lipid droplets (HP:0006565)3.46572818
10Progressive macrocephaly (HP:0004481)3.46080205
11Hepatocellular necrosis (HP:0001404)3.40979340
12Cerebral edema (HP:0002181)3.40606948
13Lipid accumulation in hepatocytes (HP:0006561)3.30496841
14Abnormality of the preputium (HP:0100587)3.30098434
15Meckel diverticulum (HP:0002245)3.26721610
16Increased serum lactate (HP:0002151)3.20614503
17Hepatic necrosis (HP:0002605)3.19287304
18Abnormality of glycolysis (HP:0004366)3.12390840
19Abnormality of the ileum (HP:0001549)3.09129607
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07875217
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07875217
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.04450910
23Increased serum pyruvate (HP:0003542)3.04396921
24Aplastic anemia (HP:0001915)2.96893703
25Type I transferrin isoform profile (HP:0003642)2.96104985
26Degeneration of anterior horn cells (HP:0002398)2.93761813
27Abnormality of the anterior horn cell (HP:0006802)2.93761813
28Lactic acidosis (HP:0003128)2.90863846
29Colon cancer (HP:0003003)2.90840218
30Abnormality of chromosome stability (HP:0003220)2.89026507
31Reticulocytopenia (HP:0001896)2.82335415
32Increased intramyocellular lipid droplets (HP:0012240)2.80807872
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80418477
34Abnormal protein N-linked glycosylation (HP:0012347)2.80418477
35Abnormal protein glycosylation (HP:0012346)2.80418477
36Abnormal glycosylation (HP:0012345)2.80418477
37Multiple enchondromatosis (HP:0005701)2.74054668
38Abnormal number of erythroid precursors (HP:0012131)2.71640379
39Birth length less than 3rd percentile (HP:0003561)2.71415504
403-Methylglutaconic aciduria (HP:0003535)2.62478057
41Abnormality of cells of the erythroid lineage (HP:0012130)2.61719023
42Exercise intolerance (HP:0003546)2.61638469
43Pancytopenia (HP:0001876)2.58500286
44Renal Fanconi syndrome (HP:0001994)2.51550491
45Abnormality of the labia minora (HP:0012880)2.51154130
46Duodenal stenosis (HP:0100867)2.45944662
47Small intestinal stenosis (HP:0012848)2.45944662
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45134201
49Lethargy (HP:0001254)2.39917255
50Hyperglycinemia (HP:0002154)2.39004391
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38253519
52Abnormality of methionine metabolism (HP:0010901)2.38036763
53Abnormality of alanine metabolism (HP:0010916)2.37168091
54Hyperalaninemia (HP:0003348)2.37168091
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37168091
56Reduced antithrombin III activity (HP:0001976)2.36274032
57Respiratory failure (HP:0002878)2.35030482
58Myelodysplasia (HP:0002863)2.34287642
59Leukodystrophy (HP:0002415)2.34187386
60Cerebral hypomyelination (HP:0006808)2.34080208
61Abnormality of serum amino acid levels (HP:0003112)2.31896603
62Increased muscle lipid content (HP:0009058)2.31624817
63Horseshoe kidney (HP:0000085)2.22235189
64Macrocytic anemia (HP:0001972)2.21976688
65Methylmalonic acidemia (HP:0002912)2.21215286
66Ependymoma (HP:0002888)2.20463061
67Sparse eyelashes (HP:0000653)2.19465255
68Methylmalonic aciduria (HP:0012120)2.19396116
69Oral leukoplakia (HP:0002745)2.18736652
70Absent thumb (HP:0009777)2.16581064
71Microretrognathia (HP:0000308)2.15882236
72Optic disc pallor (HP:0000543)2.10741819
73Abnormality of the carotid arteries (HP:0005344)2.09267037
74Respiratory difficulties (HP:0002880)2.06076371
75Abnormality of the duodenum (HP:0002246)2.05911608
76Triphalangeal thumb (HP:0001199)2.05073334
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04658504
78Rough bone trabeculation (HP:0100670)2.03056668
79Progressive muscle weakness (HP:0003323)2.03012182
80Abnormal lung lobation (HP:0002101)1.98589820
81CNS demyelination (HP:0007305)1.96493940
82Hyperglycinuria (HP:0003108)1.95533948
83Abnormality of glycine metabolism (HP:0010895)1.94026198
84Abnormality of serine family amino acid metabolism (HP:0010894)1.94026198
85Progressive external ophthalmoplegia (HP:0000590)1.93941609
86Facial cleft (HP:0002006)1.92244277
87Premature ovarian failure (HP:0008209)1.91777938
88Medulloblastoma (HP:0002885)1.88385436
89Postnatal microcephaly (HP:0005484)1.88330869
90Secondary amenorrhea (HP:0000869)1.87391779
91Cleft eyelid (HP:0000625)1.83450342
92Sloping forehead (HP:0000340)1.83135252
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82004281
94CNS hypomyelination (HP:0003429)1.81631603
95Neoplasm of the adrenal gland (HP:0100631)1.80931794
96Exertional dyspnea (HP:0002875)1.80773706
97Death in infancy (HP:0001522)1.78427313
98Bone marrow hypocellularity (HP:0005528)1.76438719
99Cholecystitis (HP:0001082)1.76383802
100Abnormal gallbladder physiology (HP:0012438)1.76383802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.62160652
2VRK23.88990448
3EIF2AK13.68508982
4SRPK13.50958702
5CDC73.49245131
6PBK2.85236294
7TSSK62.84708964
8NEK12.84507603
9TTK2.60911268
10NME22.50982575
11EIF2AK32.45620832
12ZAK2.31238805
13NME12.30374253
14STK162.20639143
15MST42.19347624
16WEE12.09486650
17VRK11.94831771
18PLK41.92219401
19PLK31.91830536
20BCKDK1.83528108
21MAP4K21.72017266
22TRIM281.69262705
23BRSK21.68158607
24PLK11.61901834
25NUAK11.59874686
26MKNK11.58803591
27MKNK21.45012552
28SCYL21.39689811
29PIM21.35462209
30PDK21.33881118
31BRSK11.32513259
32AURKB1.29827556
33ATR1.27665501
34TLK11.25295336
35CHEK21.20515521
36CCNB11.18704298
37AURKA1.12092201
38CSNK1G31.07714003
39TAF11.06363437
40TESK11.05758686
41ARAF1.05666660
42EIF2AK21.03609584
43RPS6KB21.01597606
44RPS6KA40.97680103
45PAK40.95855567
46TESK20.95085462
47SMG10.91612754
48BMPR1B0.90770571
49CSNK1G10.90482714
50CHEK10.90094188
51DYRK20.89128531
52CDK70.88782834
53MAP3K120.87495916
54DAPK10.78196996
55CSNK1A1L0.74896660
56MAP3K80.72808157
57LIMK10.70971981
58CDK80.67757832
59CSNK1G20.67730630
60ATM0.67600773
61PRKCI0.67098193
62BCR0.65375277
63BRAF0.62257102
64CSNK2A10.60940022
65RPS6KA50.60664099
66ALK0.60402293
67CSNK2A20.59553847
68STK40.59340496
69KDR0.56931455
70ABL20.54990701
71NEK20.54916140
72MAP2K70.53402547
73RAF10.51357808
74CDK90.47730265
75IRAK20.46312726
76ERBB40.46136986
77DYRK30.45324287
78CDK20.44314046
79CDK10.43966844
80PAK10.43364413
81PASK0.40965470
82SIK30.40475730
83WNK30.39034616
84AKT20.38444880
85CSNK1E0.37188691
86STK100.33632823
87TAOK20.33089385
88CDK40.32896057
89MAPKAPK50.32261372
90EPHA20.31242255
91CDK190.29846386
92CDK180.29485024
93CLK10.29063978
94CDK140.28265478
95ERBB30.26361688
96PLK20.25929728
97ILK0.25856813
98CDK150.24678038
99CDK11A0.24393355
100PIM10.22966872

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65209391
2DNA replication_Homo sapiens_hsa030304.06637471
3Mismatch repair_Homo sapiens_hsa034303.70359582
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09295349
5Ribosome_Homo sapiens_hsa030102.81721478
6Homologous recombination_Homo sapiens_hsa034402.78000108
7Base excision repair_Homo sapiens_hsa034102.73046603
8RNA polymerase_Homo sapiens_hsa030202.67744371
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66919931
10Oxidative phosphorylation_Homo sapiens_hsa001902.55249246
11Spliceosome_Homo sapiens_hsa030402.51433677
12Non-homologous end-joining_Homo sapiens_hsa034502.44894593
13Nucleotide excision repair_Homo sapiens_hsa034202.40051037
14Protein export_Homo sapiens_hsa030602.39411048
15Parkinsons disease_Homo sapiens_hsa050122.36715461
16RNA transport_Homo sapiens_hsa030132.16310237
17Fanconi anemia pathway_Homo sapiens_hsa034602.14015027
18One carbon pool by folate_Homo sapiens_hsa006702.08882478
19Pyrimidine metabolism_Homo sapiens_hsa002402.04512973
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81692297
21Huntingtons disease_Homo sapiens_hsa050161.73004961
22Basal transcription factors_Homo sapiens_hsa030221.71932397
23Cell cycle_Homo sapiens_hsa041101.67987969
24RNA degradation_Homo sapiens_hsa030181.57304208
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54999976
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51088666
27Fatty acid elongation_Homo sapiens_hsa000621.47770731
28Pyruvate metabolism_Homo sapiens_hsa006201.47557870
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.46249527
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39516137
31Alzheimers disease_Homo sapiens_hsa050101.38771996
32Sulfur relay system_Homo sapiens_hsa041221.37924597
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36753063
34Biosynthesis of amino acids_Homo sapiens_hsa012301.32731110
35Carbon metabolism_Homo sapiens_hsa012001.22189294
36Purine metabolism_Homo sapiens_hsa002301.18060836
37Propanoate metabolism_Homo sapiens_hsa006401.18036659
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15849219
39Folate biosynthesis_Homo sapiens_hsa007901.15703319
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11992007
41Selenocompound metabolism_Homo sapiens_hsa004501.07652042
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07483444
43Steroid biosynthesis_Homo sapiens_hsa001000.93415303
44Glutathione metabolism_Homo sapiens_hsa004800.92434767
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91447790
46mRNA surveillance pathway_Homo sapiens_hsa030150.88954700
47Vitamin B6 metabolism_Homo sapiens_hsa007500.87091234
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86419466
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82785233
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82448844
51p53 signaling pathway_Homo sapiens_hsa041150.82115936
52Sulfur metabolism_Homo sapiens_hsa009200.76211204
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75716189
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71159061
55Metabolic pathways_Homo sapiens_hsa011000.69258927
56N-Glycan biosynthesis_Homo sapiens_hsa005100.67422228
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65712781
58Epstein-Barr virus infection_Homo sapiens_hsa051690.65084061
59Pentose phosphate pathway_Homo sapiens_hsa000300.63048298
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63028702
61Oocyte meiosis_Homo sapiens_hsa041140.59237915
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58626329
63Peroxisome_Homo sapiens_hsa041460.55126992
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.51315200
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49258084
66Cardiac muscle contraction_Homo sapiens_hsa042600.49144735
67Arginine and proline metabolism_Homo sapiens_hsa003300.46682100
68Systemic lupus erythematosus_Homo sapiens_hsa053220.43897765
69beta-Alanine metabolism_Homo sapiens_hsa004100.43543952
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42061527
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38459309
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37861217
73Fatty acid metabolism_Homo sapiens_hsa012120.32806337
74Fructose and mannose metabolism_Homo sapiens_hsa000510.29353309
75Butanoate metabolism_Homo sapiens_hsa006500.27509467
76Galactose metabolism_Homo sapiens_hsa000520.25369073
77Vitamin digestion and absorption_Homo sapiens_hsa049770.24555287
78Herpes simplex infection_Homo sapiens_hsa051680.23551358
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21649421
80Tryptophan metabolism_Homo sapiens_hsa003800.21252711
81Fatty acid degradation_Homo sapiens_hsa000710.20914324
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19995316
83Vibrio cholerae infection_Homo sapiens_hsa051100.18901588
84Tyrosine metabolism_Homo sapiens_hsa003500.17448774
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.16862664
86Regulation of autophagy_Homo sapiens_hsa041400.16517809
87Viral carcinogenesis_Homo sapiens_hsa052030.16140245
88Shigellosis_Homo sapiens_hsa051310.15709916
89Phototransduction_Homo sapiens_hsa047440.13846367
90Antigen processing and presentation_Homo sapiens_hsa046120.12140439
91Thyroid cancer_Homo sapiens_hsa052160.12128720
92Primary immunodeficiency_Homo sapiens_hsa053400.10233538
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09573844
94Collecting duct acid secretion_Homo sapiens_hsa049660.09453419
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08450388
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08027059
97Alcoholism_Homo sapiens_hsa050340.07246200
98Phenylalanine metabolism_Homo sapiens_hsa003600.05327497
99Legionellosis_Homo sapiens_hsa051340.04871516
100Lysine degradation_Homo sapiens_hsa003100.04630093

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