MRO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)9.31814350
2glucocorticoid biosynthetic process (GO:0006704)8.48734852
3glucocorticoid metabolic process (GO:0008211)6.63276956
4amyloid precursor protein catabolic process (GO:0042987)6.28707335
5positive regulation of male gonad development (GO:2000020)6.19835626
6regulation of male gonad development (GO:2000018)5.74420783
7low-density lipoprotein particle clearance (GO:0034383)5.69312069
8adhesion of symbiont to host (GO:0044406)5.63846362
9estrogen biosynthetic process (GO:0006703)5.62009511
10positive regulation of triglyceride biosynthetic process (GO:0010867)5.40271064
11cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.40117993
12sex determination (GO:0007530)5.23073423
13cilium movement (GO:0003341)4.94122222
14positive regulation of nitric-oxide synthase activity (GO:0051000)4.86615290
15cellular response to gonadotropin stimulus (GO:0071371)4.85281836
16cholesterol catabolic process (GO:0006707)4.85032733
17sterol catabolic process (GO:0016127)4.85032733
18ovulation cycle (GO:0042698)4.66706666
19regulation of triglyceride biosynthetic process (GO:0010866)4.48298395
20axonemal dynein complex assembly (GO:0070286)4.40025409
21phagocytosis, recognition (GO:0006910)4.25489038
22response to follicle-stimulating hormone (GO:0032354)4.17528838
23piRNA metabolic process (GO:0034587)4.15069103
24regulation of meiosis I (GO:0060631)4.12844408
25amyloid precursor protein metabolic process (GO:0042982)4.01151894
26sex differentiation (GO:0007548)3.96343918
27epithelial cilium movement (GO:0003351)3.96195682
28androgen metabolic process (GO:0008209)3.96123763
29positive regulation of meiosis (GO:0045836)3.94743989
30axoneme assembly (GO:0035082)3.93201133
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.92541031
32regulation of cholesterol storage (GO:0010885)3.84745046
33positive regulation of triglyceride metabolic process (GO:0090208)3.84156869
34potassium ion import (GO:0010107)3.79752097
35negative regulation of macrophage differentiation (GO:0045650)3.76137689
36synaptic vesicle maturation (GO:0016188)3.71975188
37hormone biosynthetic process (GO:0042446)3.71594261
38cellular response to cadmium ion (GO:0071276)3.69790558
39cellular response to epinephrine stimulus (GO:0071872)3.69308399
40cilium or flagellum-dependent cell motility (GO:0001539)3.68000865
41male sex determination (GO:0030238)3.67397599
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67039079
43positive regulation of meiotic cell cycle (GO:0051446)3.66089396
44ventricular system development (GO:0021591)3.63984801
45L-amino acid import (GO:0043092)3.58042062
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.55133868
47cellular potassium ion homeostasis (GO:0030007)3.54461562
48hemoglobin metabolic process (GO:0020027)3.50709364
49vitamin A metabolic process (GO:0006776)3.47790888
50neuronal ion channel clustering (GO:0045161)3.47678757
51response to gonadotropin (GO:0034698)3.44021652
52neuron cell-cell adhesion (GO:0007158)3.43196209
53amino acid import (GO:0043090)3.42815021
54positive regulation of cellular amide metabolic process (GO:0034250)3.38155357
55glial cell proliferation (GO:0014009)3.38099078
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.35506631
57high-density lipoprotein particle remodeling (GO:0034375)3.34273910
58reverse cholesterol transport (GO:0043691)3.30549211
59regulation of gonadotropin secretion (GO:0032276)3.30076983
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27951027
61positive regulation of monooxygenase activity (GO:0032770)3.25352583
62negative regulation of astrocyte differentiation (GO:0048712)3.22849259
63endothelial cell proliferation (GO:0001935)3.21176771
64locomotory exploration behavior (GO:0035641)3.21070013
65detection of molecule of bacterial origin (GO:0032490)3.20071677
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19902039
67response to epinephrine (GO:0071871)3.18173244
68glutamate receptor signaling pathway (GO:0007215)3.17536009
69male genitalia development (GO:0030539)3.17501581
70cellular response to toxic substance (GO:0097237)3.15051115
71regulation of female gonad development (GO:2000194)3.13349709
72synaptic transmission, glutamatergic (GO:0035249)3.13007505
73neurotransmitter-gated ion channel clustering (GO:0072578)3.12517931
74layer formation in cerebral cortex (GO:0021819)3.11750491
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09410570
76DNA methylation involved in gamete generation (GO:0043046)3.09277978
77response to auditory stimulus (GO:0010996)3.04547394
78regulation of triglyceride metabolic process (GO:0090207)3.03787246
79peripheral nervous system axon ensheathment (GO:0032292)3.03434649
80myelination in peripheral nervous system (GO:0022011)3.03434649
81postsynaptic membrane organization (GO:0001941)3.00860266
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00824349
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00799219
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99354257
85synaptic vesicle exocytosis (GO:0016079)2.98378185
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97086578
87C21-steroid hormone biosynthetic process (GO:0006700)2.96566644
88gamma-aminobutyric acid transport (GO:0015812)2.96217955
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96082958
90neurotransmitter uptake (GO:0001504)2.94017775
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93640771
92Sertoli cell development (GO:0060009)2.93422303
93presynaptic membrane assembly (GO:0097105)2.93008051
94regulation of synaptic vesicle exocytosis (GO:2000300)2.92338888
95benzene-containing compound metabolic process (GO:0042537)2.92235525
96astrocyte development (GO:0014002)2.91970512
97male meiosis (GO:0007140)2.91533919
98motile cilium assembly (GO:0044458)2.90769209
99vocalization behavior (GO:0071625)2.90277212
100cellular sodium ion homeostasis (GO:0006883)2.90276130
101pyrimidine nucleobase catabolic process (GO:0006208)2.89882378
102regulation of beta-amyloid formation (GO:1902003)2.88661775
103response to corticosterone (GO:0051412)2.88236805
104regulation of transforming growth factor beta2 production (GO:0032909)2.87305989
105response to leptin (GO:0044321)2.84201086
106interleukin-6-mediated signaling pathway (GO:0070102)2.84141347
107sodium-independent organic anion transport (GO:0043252)2.82495145
108growth hormone secretion (GO:0030252)2.81375216
109negative regulation of hormone metabolic process (GO:0032351)2.80273608
110negative regulation of hormone biosynthetic process (GO:0032353)2.80273608
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80102412
112kidney morphogenesis (GO:0060993)2.79003885
113response to lead ion (GO:0010288)2.78216860
114central nervous system myelination (GO:0022010)2.76147005
115axon ensheathment in central nervous system (GO:0032291)2.76147005
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.75975506
117sodium ion export (GO:0071436)2.75437424
118cerebellar granule cell differentiation (GO:0021707)2.73391538
119neuron-neuron synaptic transmission (GO:0007270)2.73118344
120auditory behavior (GO:0031223)2.71373237
121regulation of synaptic vesicle transport (GO:1902803)2.69969669
122neurotransmitter secretion (GO:0007269)2.69498000
123positive regulation of astrocyte differentiation (GO:0048711)2.69228936
124neuronal action potential propagation (GO:0019227)2.68691187
125regulation of glutamate receptor signaling pathway (GO:1900449)2.67696343
126plasma lipoprotein particle clearance (GO:0034381)2.66894466
127presynaptic membrane organization (GO:0097090)2.66670931
128transmission of nerve impulse (GO:0019226)2.66395559
129cellular response to antibiotic (GO:0071236)2.65689786
130protein localization to synapse (GO:0035418)2.65127561
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.65059983
132response to mineralocorticoid (GO:0051385)2.64454675
133chondroitin sulfate catabolic process (GO:0030207)2.64210145
134steroid catabolic process (GO:0006706)2.61742174
135fusion of sperm to egg plasma membrane (GO:0007342)2.60552788
136nucleobase catabolic process (GO:0046113)2.60352749
137positive regulation of lipid storage (GO:0010884)2.59494335
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58619754
139neurotransmitter transport (GO:0006836)2.58144327
140estrogen metabolic process (GO:0008210)2.57559496
141circadian sleep/wake cycle process (GO:0022410)2.57419949
142long-term synaptic potentiation (GO:0060291)2.57090289
143cell communication by electrical coupling (GO:0010644)2.55936456
144long-term memory (GO:0007616)2.54999285
145positive regulation of reproductive process (GO:2000243)2.53037655
146C4-dicarboxylate transport (GO:0015740)2.51419817
147androgen biosynthetic process (GO:0006702)2.50609423
148potassium ion homeostasis (GO:0055075)2.49347214
149innervation (GO:0060384)2.48871274
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.48306309
151membrane repolarization (GO:0086009)2.47294746
152regulation of respiratory system process (GO:0044065)2.45310386
153neuron recognition (GO:0008038)2.44565870
154regulation of neuronal synaptic plasticity (GO:0048168)2.44544469
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44121748
156positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.42232970
157oligodendrocyte differentiation (GO:0048709)2.41704561
158glomerulus development (GO:0032835)2.40403638
159startle response (GO:0001964)2.39937889
160protein localization to cilium (GO:0061512)2.39671251
161regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39448376
162glutamate secretion (GO:0014047)2.39369401
163left/right axis specification (GO:0070986)2.39260307
164alanine transport (GO:0032328)2.38996859
165negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37319471
166positive regulation of sodium ion transmembrane transport (GO:1902307)2.35750181
167synaptonemal complex organization (GO:0070193)2.34628377
168negative regulation of protein localization to cell surface (GO:2000009)2.32809182
169myelination (GO:0042552)2.32635195
170membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32187119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.14994165
2GBX2_23144817_ChIP-Seq_PC3_Human3.19981385
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68274567
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63404433
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55770210
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43398166
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36207052
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36207052
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.29149213
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28368869
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24487113
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.24017224
13AR_21572438_ChIP-Seq_LNCaP_Human2.19143312
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17404811
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16819155
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.15422879
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11241035
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.05208264
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02710075
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94519456
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93086975
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.90499234
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88491903
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83716983
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78153245
26RNF2_27304074_Chip-Seq_NSC_Mouse1.76080880
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75439859
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74860427
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74854483
30DROSHA_22980978_ChIP-Seq_HELA_Human1.71872299
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69764155
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64154069
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62830674
34SMAD4_21799915_ChIP-Seq_A2780_Human1.60380700
35REST_21632747_ChIP-Seq_MESCs_Mouse1.59735902
36* PIAS1_25552417_ChIP-Seq_VCAP_Human1.56389087
37P300_19829295_ChIP-Seq_ESCs_Human1.52569492
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51686518
39TAF15_26573619_Chip-Seq_HEK293_Human1.51357835
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51051606
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49781132
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47058537
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45593678
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.43604302
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.38955988
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35337001
47TP53_16413492_ChIP-PET_HCT116_Human1.34507257
48IGF1R_20145208_ChIP-Seq_DFB_Human1.34121517
49EGR1_19032775_ChIP-ChIP_M12_Human1.33328750
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33005842
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.32253492
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32169048
53STAT3_23295773_ChIP-Seq_U87_Human1.31835699
54BCAT_22108803_ChIP-Seq_LS180_Human1.31422100
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30685166
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27889375
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27889375
58FUS_26573619_Chip-Seq_HEK293_Human1.27758986
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26865954
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25591208
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25287006
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24518133
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24151182
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.23921900
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23802080
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23692212
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23584266
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23454746
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23296015
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23256876
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23026628
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21099168
73AR_25329375_ChIP-Seq_VCAP_Human1.19386718
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18815792
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17143056
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.16576460
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15160093
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13801839
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.12242419
80ER_23166858_ChIP-Seq_MCF-7_Human1.11594597
81* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11279069
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.11110330
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10982947
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.10634983
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10424782
86TCF4_23295773_ChIP-Seq_U87_Human1.09963467
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.09715979
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09515764
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08830719
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08171898
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08121752
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07165732
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.07033270
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06896047
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.05487642
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05223261
97AR_19668381_ChIP-Seq_PC3_Human1.04994068
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04227620
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03299922
100RUNX2_22187159_ChIP-Seq_PCA_Human1.03268489
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02680469
102AHR_22903824_ChIP-Seq_MCF-7_Human1.01593219
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01021565
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.00765285
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.00534244
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99200707
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.99152809
108E2F1_18555785_Chip-Seq_ESCs_Mouse0.98560101
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.98133256
110RXR_22108803_ChIP-Seq_LS180_Human0.97516554
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97265873
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97183706
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97085865
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96864814
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.95632700
116* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94396033
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93122231
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.93026045
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.92805543
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.92382128
121LXR_22158963_ChIP-Seq_LIVER_Mouse0.90608415
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.90222560
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89305322
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.87966009
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87841889
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83487259
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.82519386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.22488146
2MP0008995_early_reproductive_senescence3.59587153
3MP0003136_yellow_coat_color3.41641950
4MP0004859_abnormal_synaptic_plasticity3.04891081
5MP0003011_delayed_dark_adaptation2.94194656
6MP0003880_abnormal_central_pattern2.93953651
7MP0003878_abnormal_ear_physiology2.90547519
8MP0005377_hearing/vestibular/ear_phenot2.90547519
9MP0008875_abnormal_xenobiotic_pharmacok2.80194124
10MP0005646_abnormal_pituitary_gland2.74881764
11MP0005171_absent_coat_pigmentation2.71033708
12MP0001440_abnormal_grooming_behavior2.55023560
13MP0008877_abnormal_DNA_methylation2.52240563
14MP0009384_cardiac_valve_regurgitation2.39702700
15MP0003635_abnormal_synaptic_transmissio2.37701656
16MP0001486_abnormal_startle_reflex2.36572430
17MP0002876_abnormal_thyroid_physiology2.32159244
18MP0002909_abnormal_adrenal_gland2.28683769
19MP0002102_abnormal_ear_morphology2.27322192
20MP0003879_abnormal_hair_cell2.25055576
21MP0009046_muscle_twitch2.24303248
22MP0010329_abnormal_lipoprotein_level2.23371110
23MP0000639_abnormal_adrenal_gland2.14556370
24MP0009745_abnormal_behavioral_response2.08302669
25MP0002572_abnormal_emotion/affect_behav2.06645292
26MP0002063_abnormal_learning/memory/cond1.95338946
27MP0003690_abnormal_glial_cell1.92751034
28MP0002653_abnormal_ependyma_morphology1.88562085
29MP0002064_seizures1.88515613
30MP0002272_abnormal_nervous_system1.88003667
31MP0004742_abnormal_vestibular_system1.82049373
32MP0005410_abnormal_fertilization1.81365014
33MP0005623_abnormal_meninges_morphology1.79637705
34MP0009780_abnormal_chondrocyte_physiolo1.79211095
35MP0005423_abnormal_somatic_nervous1.72827634
36MP0004858_abnormal_nervous_system1.71283388
37MP0001188_hyperpigmentation1.68094082
38MP0001968_abnormal_touch/_nociception1.65570966
39MP0000920_abnormal_myelination1.65154357
40MP0000778_abnormal_nervous_system1.62564142
41MP0004270_analgesia1.62195388
42MP0003300_gastrointestinal_ulcer1.61371602
43MP0004885_abnormal_endolymph1.61317529
44MP0002557_abnormal_social/conspecific_i1.61064762
45MP0003633_abnormal_nervous_system1.59483624
46MP0002736_abnormal_nociception_after1.50947401
47MP0001485_abnormal_pinna_reflex1.48608867
48MP0003787_abnormal_imprinting1.45770891
49MP0005647_abnormal_sex_gland1.43363336
50MP0001984_abnormal_olfaction1.42326513
51MP0003329_amyloid_beta_deposits1.41361143
52MP0002067_abnormal_sensory_capabilities1.40621093
53MP0001501_abnormal_sleep_pattern1.38857605
54MP0004215_abnormal_myocardial_fiber1.36020948
55MP0008872_abnormal_physiological_respon1.34407081
56MP0003698_abnormal_male_reproductive1.33545858
57MP0000631_abnormal_neuroendocrine_gland1.33237318
58MP0002332_abnormal_exercise_endurance1.32299282
59MP0005365_abnormal_bile_salt1.31104976
60MP0002734_abnormal_mechanical_nocicepti1.28921083
61MP0003045_fibrosis1.24230579
62MP0003724_increased_susceptibility_to1.22280018
63MP0002733_abnormal_thermal_nociception1.22225139
64MP0005334_abnormal_fat_pad1.20334716
65MP0002210_abnormal_sex_determination1.19579442
66MP0005645_abnormal_hypothalamus_physiol1.19310440
67MP0000604_amyloidosis1.17946061
68MP0001963_abnormal_hearing_physiology1.17702927
69MP0003075_altered_response_to1.17444377
70MP0003634_abnormal_glial_cell1.14739850
71MP0001929_abnormal_gametogenesis1.13156971
72MP0000751_myopathy1.12740371
73MP0005535_abnormal_body_temperature1.12668581
74MP0001970_abnormal_pain_threshold1.10432947
75MP0004019_abnormal_vitamin_homeostasis1.08307945
76MP0003195_calcinosis1.06732101
77MP0002882_abnormal_neuron_morphology1.05038725
78MP0001661_extended_life_span1.04865204
79MP0002118_abnormal_lipid_homeostasis1.04534986
80MP0006276_abnormal_autonomic_nervous1.04468007
81MP0001905_abnormal_dopamine_level1.03928462
82MP0002184_abnormal_innervation1.03825567
83MP0001502_abnormal_circadian_rhythm1.03695776
84MP0002229_neurodegeneration1.02602591
85MP0005551_abnormal_eye_electrophysiolog1.02396988
86MP0003315_abnormal_perineum_morphology1.02183071
87MP0002735_abnormal_chemical_nociception1.01685010
88MP0000026_abnormal_inner_ear1.01222045
89MP0000566_synostosis1.00852053
90MP0008569_lethality_at_weaning0.97759695
91MP0002638_abnormal_pupillary_reflex0.97593506
92MP0003632_abnormal_nervous_system0.97017085
93MP0004043_abnormal_pH_regulation0.96920234
94MP0002249_abnormal_larynx_morphology0.96750972
95MP0004924_abnormal_behavior0.96604936
96MP0005386_behavior/neurological_phenoty0.96604936
97MP0005670_abnormal_white_adipose0.96236268
98MP0002152_abnormal_brain_morphology0.94783970
99MP0000049_abnormal_middle_ear0.93049127
100MP0001145_abnormal_male_reproductive0.92182529
101MP0003953_abnormal_hormone_level0.91686567
102MP0004145_abnormal_muscle_electrophysio0.91537602
103MP0009840_abnormal_foam_cell0.90812938
104MP0000653_abnormal_sex_gland0.90212420
105MP0000955_abnormal_spinal_cord0.89638096
106MP0006292_abnormal_olfactory_placode0.89085766
107MP0003646_muscle_fatigue0.86797213
108MP0002160_abnormal_reproductive_system0.86255553
109MP0001529_abnormal_vocalization0.85342492
110MP0003283_abnormal_digestive_organ0.84725930
111MP0005167_abnormal_blood-brain_barrier0.84506858
112MP0001958_emphysema0.84419427
113MP0005448_abnormal_energy_balance0.84217762
114MP0002822_catalepsy0.84158391
115MP0005332_abnormal_amino_acid0.83510624
116MP0004130_abnormal_muscle_cell0.81840186
117MP0003941_abnormal_skin_development0.81011280
118MP0003631_nervous_system_phenotype0.79589809
119MP0001986_abnormal_taste_sensitivity0.78330810
120MP0002066_abnormal_motor_capabilities/c0.78313473
121MP0004510_myositis0.77574353
122MP0003942_abnormal_urinary_system0.77011262
123MP0002752_abnormal_somatic_nervous0.76357682
124MP0003936_abnormal_reproductive_system0.75643163
125MP0005595_abnormal_vascular_smooth0.75382478
126MP0005389_reproductive_system_phenotype0.75152350
127MP0002254_reproductive_system_inflammat0.75130412
128MP0000230_abnormal_systemic_arterial0.75117171
129MP0002168_other_aberrant_phenotype0.74467700
130MP0009250_abnormal_appendicular_skeleto0.73467130
131MP0005253_abnormal_eye_physiology0.72915957
132MP0004142_abnormal_muscle_tone0.72560605
133MP0001919_abnormal_reproductive_system0.72156438
134MP0005166_decreased_susceptibility_to0.70085089
135MP0002090_abnormal_vision0.70020996
136MP0003137_abnormal_impulse_conducting0.69744750
137MP0004883_abnormal_blood_vessel0.68623605
138MP0010386_abnormal_urinary_bladder0.65132418
139MP0005085_abnormal_gallbladder_physiolo0.64223759
140MP0001177_atelectasis0.64207345
141MP0002069_abnormal_eating/drinking_beha0.63208300
142MP0004147_increased_porphyrin_level0.63095010

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pulmonary veins (HP:0011718)7.71699813
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.99575698
3Abnormal respiratory motile cilium physiology (HP:0012261)6.47382768
4Abnormal ciliary motility (HP:0012262)6.45993509
5Relative macrocephaly (HP:0004482)5.30908389
6Absent/shortened dynein arms (HP:0200106)5.30174881
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.30174881
8Large earlobe (HP:0009748)5.14536447
9Male infertility (HP:0003251)5.13541832
10Gonadal dysgenesis (HP:0000133)4.92802220
11Rhinitis (HP:0012384)4.87178856
12Abnormal respiratory epithelium morphology (HP:0012253)4.85855226
13Abnormal respiratory motile cilium morphology (HP:0005938)4.85855226
14Partial agenesis of the corpus callosum (HP:0001338)4.80559221
15Male pseudohermaphroditism (HP:0000037)4.57275023
16Split foot (HP:0001839)4.55532141
17Oligodactyly (hands) (HP:0001180)4.55225422
18Abnormal sex determination (HP:0012244)4.20845307
19Sex reversal (HP:0012245)4.20845307
20Renal salt wasting (HP:0000127)4.05037301
21Focal motor seizures (HP:0011153)3.95794376
22Cupped ear (HP:0000378)3.85660350
23Aplasia involving bones of the extremities (HP:0009825)3.84366869
24Aplasia involving bones of the upper limbs (HP:0009823)3.84366869
25Aplasia of the phalanges of the hand (HP:0009802)3.84366869
26Stenosis of the external auditory canal (HP:0000402)3.71578669
27Action tremor (HP:0002345)3.68740358
28Hypoplastic left heart (HP:0004383)3.61541274
29Cerebral palsy (HP:0100021)3.56228680
30Congenital malformation of the right heart (HP:0011723)3.45742513
31Double outlet right ventricle (HP:0001719)3.45742513
32Infertility (HP:0000789)3.29548774
33Hyperaldosteronism (HP:0000859)3.26059075
34Gonadotropin excess (HP:0000837)3.24539494
35Diplopia (HP:0000651)3.24244759
36Abnormality of binocular vision (HP:0011514)3.24244759
37Increased circulating renin level (HP:0000848)2.99024280
38Ureteral duplication (HP:0000073)2.97645050
39Megalencephaly (HP:0001355)2.90308064
40Atonic seizures (HP:0010819)2.86646712
41Hypoplastic heart (HP:0001961)2.81530429
42Epileptic encephalopathy (HP:0200134)2.79517001
43True hermaphroditism (HP:0010459)2.78753418
44Abnormal eating behavior (HP:0100738)2.77848900
45Clumsiness (HP:0002312)2.76758095
46Abnormality of the alveolar ridges (HP:0006477)2.76511876
47Choroideremia (HP:0001139)2.76130817
48Diastasis recti (HP:0001540)2.67145400
49Hypoplasia of the uterus (HP:0000013)2.66677190
50Chronic bronchitis (HP:0004469)2.66144484
51Occipital encephalocele (HP:0002085)2.60974002
52Testicular neoplasm (HP:0010788)2.60932181
53Mixed hearing impairment (HP:0000410)2.58924485
54Rhizomelia (HP:0008905)2.55955763
55Abnormality of the aortic arch (HP:0012303)2.54196859
56Abnormal drinking behavior (HP:0030082)2.53804523
57Polydipsia (HP:0001959)2.53804523
58Nephronophthisis (HP:0000090)2.49416214
59Mutism (HP:0002300)2.48725012
60Absent speech (HP:0001344)2.47969010
61Aplasia/hypoplasia of the uterus (HP:0008684)2.45202734
62Focal seizures (HP:0007359)2.40608662
63Generalized tonic-clonic seizures (HP:0002069)2.39817182
64Gait imbalance (HP:0002141)2.35817429
65Bronchiectasis (HP:0002110)2.34925935
66Ankle clonus (HP:0011448)2.34732323
67Medial flaring of the eyebrow (HP:0010747)2.34356135
68Abnormality of male internal genitalia (HP:0000022)2.34318548
69Dialeptic seizures (HP:0011146)2.34247755
70Growth hormone excess (HP:0000845)2.33213344
71Acanthosis nigricans (HP:0000956)2.32852183
72Abnormality of molar (HP:0011077)2.30575691
73Abnormality of molar morphology (HP:0011070)2.30575691
74Humeroradial synostosis (HP:0003041)2.30373296
75Synostosis involving the elbow (HP:0003938)2.30373296
76Abnormality of dentin (HP:0010299)2.29814823
77Tubulointerstitial nephritis (HP:0001970)2.29658482
78Absence seizures (HP:0002121)2.29635850
79Hyperventilation (HP:0002883)2.27635660
80Hypoplastic nipples (HP:0002557)2.24676179
81Stage 5 chronic kidney disease (HP:0003774)2.24266403
82Myokymia (HP:0002411)2.24113287
83Abnormality of the dental root (HP:0006486)2.23454417
84Taurodontia (HP:0000679)2.23454417
85Abnormality of permanent molar morphology (HP:0011071)2.23454417
86Congenital primary aphakia (HP:0007707)2.22992237
87Median cleft lip (HP:0000161)2.22815620
88Hemiparesis (HP:0001269)2.22330665
89Hyperpituitarism (HP:0010514)2.21833077
90Abnormality of the dental pulp (HP:0006479)2.21135482
91Azoospermia (HP:0000027)2.21006026
92Intention tremor (HP:0002080)2.20918070
93Abnormal pancreas size (HP:0012094)2.18876194
94Metabolic alkalosis (HP:0200114)2.15973057
95Pancreatic fibrosis (HP:0100732)2.13387059
96Polyphagia (HP:0002591)2.11520887
97Hypomagnesemia (HP:0002917)2.10413392
98Hyperglycemia (HP:0003074)2.10210348
99Nephrogenic diabetes insipidus (HP:0009806)2.06312774
100Accelerated skeletal maturation (HP:0005616)2.03049483
101Abnormality of the renal medulla (HP:0100957)2.00330848
102Genital tract atresia (HP:0001827)1.97585572
103Follicular hyperkeratosis (HP:0007502)1.95091099
104Mitral stenosis (HP:0001718)1.93856058
105Fibular hypoplasia (HP:0003038)1.92991880
106Limb dystonia (HP:0002451)1.92775382
107Supernumerary nipples (HP:0002558)1.91554203
108Syncope (HP:0001279)1.91407929
109Abnormality of secondary sexual hair (HP:0009888)1.89715535
110Abnormality of the axillary hair (HP:0100134)1.89715535
111Hypokalemic alkalosis (HP:0001949)1.89080813
112Germ cell neoplasia (HP:0100728)1.88354608
113Truncal ataxia (HP:0002078)1.87761704
114Short middle phalanx of the 5th finger (HP:0004220)1.87702079
115Retinal atrophy (HP:0001105)1.87676994
116Narrow nasal bridge (HP:0000446)1.86127117
117Vaginal atresia (HP:0000148)1.85910221
118Abnormality of the nasal septum (HP:0000419)1.85046296
119Progressive cerebellar ataxia (HP:0002073)1.84824272
120Arthropathy (HP:0003040)1.83635434
121Molar tooth sign on MRI (HP:0002419)1.83603471
122Abnormality of midbrain morphology (HP:0002418)1.83603471
123Urinary bladder sphincter dysfunction (HP:0002839)1.80398393
124Poor coordination (HP:0002370)1.80172616
125Mesangial abnormality (HP:0001966)1.79688088
126Polyuria (HP:0000103)1.79569661
127Dysdiadochokinesis (HP:0002075)1.79387864
128Primary amenorrhea (HP:0000786)1.79228230
129Neurofibrillary tangles (HP:0002185)1.78776679
130Metaphyseal dysplasia (HP:0100255)1.78751214
131Insulin resistance (HP:0000855)1.78193536
132Cutaneous syndactyly (HP:0012725)1.75361655
133Peripheral hypomyelination (HP:0007182)1.75171590
134Adrenal overactivity (HP:0002717)1.74699271
135Abnormality of magnesium homeostasis (HP:0004921)1.74157605
136Aplasia/Hypoplasia of the fibula (HP:0006492)1.73692057
137Hemiplegia (HP:0002301)1.73603115
138Postaxial foot polydactyly (HP:0001830)1.72210933
139Truncus arteriosus (HP:0001660)1.69227278
140Febrile seizures (HP:0002373)1.69162246
141Patent foramen ovale (HP:0001655)1.68482547
142Gaze-evoked nystagmus (HP:0000640)1.68139853
143Papilledema (HP:0001085)1.67602104
144Polycystic ovaries (HP:0000147)1.67566159
145Lower limb asymmetry (HP:0100559)1.67155118
146Tubular atrophy (HP:0000092)1.66394640
147Anomalous pulmonary venous return (HP:0010772)1.64935449
148Neonatal short-limb short stature (HP:0008921)1.64775841
149Bronchomalacia (HP:0002780)1.64697310
150Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64633257
151Bifid tongue (HP:0010297)1.64372447
152Aplasia/Hypoplasia of the lens (HP:0008063)1.64112893
153Congenital stationary night blindness (HP:0007642)1.63931557
154Cutaneous finger syndactyly (HP:0010554)1.62559928
155Preaxial hand polydactyly (HP:0001177)1.62082506
156Hypoplastic iliac wings (HP:0002866)1.61267824
157Supernumerary spleens (HP:0009799)1.61111929
158Tongue fasciculations (HP:0001308)1.60994663
159Hypoplasia of the iris (HP:0007676)1.60552911
160Broad-based gait (HP:0002136)1.59429076
161Vertebral clefting (HP:0008428)1.59175355
162Postaxial hand polydactyly (HP:0001162)1.58161796
163Oligodactyly (HP:0012165)1.58016082
164Short femoral neck (HP:0100864)1.57878255
165Epileptiform EEG discharges (HP:0011182)1.57357534
166Supranuclear gaze palsy (HP:0000605)1.57351512
167Abnormal urine output (HP:0012590)1.56593209
168Status epilepticus (HP:0002133)1.56485232
169Decreased electroretinogram (ERG) amplitude (HP:0000654)1.55227659
170Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.55066545
171Spastic gait (HP:0002064)1.54570672
172Long nose (HP:0003189)1.54125250
173Morphological abnormality of the middle ear (HP:0008609)1.53632256
174Pulmonary artery stenosis (HP:0004415)1.52043851
175Pancreatic cysts (HP:0001737)1.51266812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.96144392
2CASK3.56398363
3TNIK3.43105043
4TYRO33.11756809
5NTRK33.07311205
6NTRK22.98405561
7MAP3K42.96934766
8MAP2K72.79637695
9PRKD32.70810553
10FRK2.65473023
11LMTK22.17117509
12ICK2.10875987
13TAOK31.86881302
14MAPK131.86388511
15MUSK1.80666391
16PHKG21.77231416
17PHKG11.77231416
18WNK31.74212939
19PNCK1.67199983
20CAMKK11.65469653
21UHMK11.64312175
22LATS11.64109576
23MAPK151.52251937
24DAPK21.51983525
25PRPF4B1.50957778
26MKNK21.50530100
27JAK11.37884890
28TNK21.36685659
29PTK2B1.34946933
30CAMK41.34838700
31MARK11.31923983
32AKT31.28247532
33SGK21.27497749
34DMPK1.23853917
35DYRK21.22726427
36NEK61.22139869
37SGK2231.21457512
38SGK4941.21457512
39CAMKK21.21384139
40ARAF1.20160775
41PLK21.19656393
42ADRBK21.17067264
43MAP2K41.17005436
44STK111.13311590
45MINK11.12753688
46FES1.12060083
47CDK31.11818724
48FGR1.11206373
49LATS21.01963759
50CDK90.94466508
51CAMK10.94166302
52CAMK2G0.92025436
53PINK10.91980110
54PAK60.89549345
55ACVR1B0.89081472
56PRKCG0.88018227
57WNK10.87705750
58BMPR20.84437347
59PDK10.83606148
60CAMK2D0.81516869
61CDK50.80256822
62MAPK70.79399865
63MAP3K90.79223792
64CAMK2A0.79126352
65GRK10.78513807
66CDC42BPA0.77912621
67DYRK1A0.75353420
68INSRR0.75198417
69GRK50.73951329
70MAPK120.71397770
71SGK30.70882678
72MAPKAPK50.70183173
73CAMK1G0.70106181
74RPS6KA50.70064560
75PRKCE0.69988991
76FER0.69443395
77PRKCH0.69247405
78MAP3K60.67812435
79JAK20.66550626
80STK38L0.66110951
81STK380.65817783
82SIK20.65270233
83ABL20.63005069
84MAP3K130.62951059
85DDR20.61202813
86ROCK10.59033945
87GRK70.58234415
88CSNK1A10.57859534
89PRKCZ0.57253312
90CDK120.56017393
91CDK150.55269096
92DAPK10.54966650
93SGK10.54821761
94MAP3K110.54690589
95CDK180.53627684
96MAP2K10.52063030
97PDGFRA0.51941446
98CDK80.51463564
99CDK140.51415774
100NLK0.51346817
101CSNK1G20.48894928
102MAP2K20.48653500
103OXSR10.48585395
104MAPK100.48329452
105PRKCA0.46624799
106CDK11A0.45503962
107PRKACG0.45124261
108STK390.43685061
109MAP2K60.43322712
110MAPK40.43100468
111PRKD20.43048074
112CSNK1D0.42798026
113TAOK20.42507102
114SIK10.42378908
115PDPK10.41879561
116RIPK40.41788505
117LIMK10.40603622
118BRD40.39613155
119NTRK10.38993680
120RPS6KA30.37758818
121BRAF0.37097859
122PKN10.36802207
123KSR20.36568561
124PTK60.36104395
125ROCK20.35354692
126MOS0.35165344
127PRKACA0.35034289
128PDGFRB0.34932026
129BMPR1B0.34875992
130WNK40.34797943
131PDK20.34774672
132RET0.33361405
133PRKG10.33103636
134ERBB40.32897491
135MARK20.31860852
136PAK30.31420795
137CAMK1D0.31348525
138KSR10.30839116
139CAMK2B0.30558500
140CDK70.30068413
141GSK3B0.29899267
142CSNK1A1L0.29856537
143PRKACB0.29779902

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.42216022
2Nicotine addiction_Homo sapiens_hsa050333.36984854
3Fatty acid biosynthesis_Homo sapiens_hsa000612.62299518
4Glutamatergic synapse_Homo sapiens_hsa047242.31772094
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09556332
6GABAergic synapse_Homo sapiens_hsa047272.05600798
7Circadian entrainment_Homo sapiens_hsa047131.98345082
8Salivary secretion_Homo sapiens_hsa049701.94324384
9Renin secretion_Homo sapiens_hsa049241.85973984
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85806727
11Morphine addiction_Homo sapiens_hsa050321.85252335
12Ovarian steroidogenesis_Homo sapiens_hsa049131.83049681
13Dorso-ventral axis formation_Homo sapiens_hsa043201.83047850
14Amphetamine addiction_Homo sapiens_hsa050311.81911908
15Long-term potentiation_Homo sapiens_hsa047201.81770239
16Gastric acid secretion_Homo sapiens_hsa049711.78948855
17Olfactory transduction_Homo sapiens_hsa047401.75125240
18cAMP signaling pathway_Homo sapiens_hsa040241.68680019
19Calcium signaling pathway_Homo sapiens_hsa040201.68585139
20Axon guidance_Homo sapiens_hsa043601.67844705
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67789288
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66167358
23Cocaine addiction_Homo sapiens_hsa050301.54605377
24Hedgehog signaling pathway_Homo sapiens_hsa043401.53510958
25Insulin secretion_Homo sapiens_hsa049111.52095798
26Nitrogen metabolism_Homo sapiens_hsa009101.47799175
27Taste transduction_Homo sapiens_hsa047421.42745445
28Synaptic vesicle cycle_Homo sapiens_hsa047211.40369534
29Long-term depression_Homo sapiens_hsa047301.38885684
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38218868
31Dopaminergic synapse_Homo sapiens_hsa047281.36215193
32Serotonergic synapse_Homo sapiens_hsa047261.33206824
33Mineral absorption_Homo sapiens_hsa049781.33064624
34Histidine metabolism_Homo sapiens_hsa003401.29181146
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26112965
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22911126
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22067502
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21976015
39Oxytocin signaling pathway_Homo sapiens_hsa049211.20895236
40beta-Alanine metabolism_Homo sapiens_hsa004101.17667869
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.13836504
42Fat digestion and absorption_Homo sapiens_hsa049751.12869927
43Melanogenesis_Homo sapiens_hsa049161.12328895
44GnRH signaling pathway_Homo sapiens_hsa049121.11142108
45Caffeine metabolism_Homo sapiens_hsa002321.10837350
46Basal cell carcinoma_Homo sapiens_hsa052171.10148443
47Circadian rhythm_Homo sapiens_hsa047101.07830145
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07741008
49Cholinergic synapse_Homo sapiens_hsa047251.06234349
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.04430614
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04111094
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03002908
53Ether lipid metabolism_Homo sapiens_hsa005651.02092139
54Pancreatic secretion_Homo sapiens_hsa049721.01255668
55Chemical carcinogenesis_Homo sapiens_hsa052040.99387777
56Vitamin digestion and absorption_Homo sapiens_hsa049770.95708065
57Tryptophan metabolism_Homo sapiens_hsa003800.95127992
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93989993
59Fatty acid metabolism_Homo sapiens_hsa012120.93424371
60Butanoate metabolism_Homo sapiens_hsa006500.93391267
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92979513
62Wnt signaling pathway_Homo sapiens_hsa043100.92757024
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91384749
64TGF-beta signaling pathway_Homo sapiens_hsa043500.89868990
65Sphingolipid metabolism_Homo sapiens_hsa006000.89804937
66Gap junction_Homo sapiens_hsa045400.87674152
67Estrogen signaling pathway_Homo sapiens_hsa049150.87365360
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.87230842
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87137645
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85602542
71Phototransduction_Homo sapiens_hsa047440.84293821
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83728214
73Choline metabolism in cancer_Homo sapiens_hsa052310.82538472
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79088912
75Fatty acid elongation_Homo sapiens_hsa000620.78681323
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78441263
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77927124
78ErbB signaling pathway_Homo sapiens_hsa040120.75232968
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75218909
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75133502
81ECM-receptor interaction_Homo sapiens_hsa045120.74706380
82Linoleic acid metabolism_Homo sapiens_hsa005910.74055650
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71220952
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70361213
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67753417
86Ras signaling pathway_Homo sapiens_hsa040140.66676192
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65951654
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64676125
89Thyroid hormone synthesis_Homo sapiens_hsa049180.63406861
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.62969959
91Protein digestion and absorption_Homo sapiens_hsa049740.62917649
92Hippo signaling pathway_Homo sapiens_hsa043900.62672583
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61067252
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.59518569
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58826645
96MAPK signaling pathway_Homo sapiens_hsa040100.56916437
97Collecting duct acid secretion_Homo sapiens_hsa049660.56527194
98Rap1 signaling pathway_Homo sapiens_hsa040150.56086827
99Bile secretion_Homo sapiens_hsa049760.54838841
100Propanoate metabolism_Homo sapiens_hsa006400.54827117
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53411597
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.53389463
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53093797
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52976565
105ABC transporters_Homo sapiens_hsa020100.52189456
106Fatty acid degradation_Homo sapiens_hsa000710.52020789
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50749783
108Vitamin B6 metabolism_Homo sapiens_hsa007500.50355254
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50248172
110Dilated cardiomyopathy_Homo sapiens_hsa054140.50015469
111Arachidonic acid metabolism_Homo sapiens_hsa005900.48850076
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47178571
113PPAR signaling pathway_Homo sapiens_hsa033200.47142208
114Arginine and proline metabolism_Homo sapiens_hsa003300.46690414
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44771509
116Glioma_Homo sapiens_hsa052140.43639594
117Glucagon signaling pathway_Homo sapiens_hsa049220.43052065
118Type II diabetes mellitus_Homo sapiens_hsa049300.40611831
119Cardiac muscle contraction_Homo sapiens_hsa042600.38448089
120Oocyte meiosis_Homo sapiens_hsa041140.37671679
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.35979783
122Prion diseases_Homo sapiens_hsa050200.34448531
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.33843589
124Inositol phosphate metabolism_Homo sapiens_hsa005620.33546681
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31120924
126Glycerolipid metabolism_Homo sapiens_hsa005610.29248810

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