MROH2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a HEAT-domain-containing protein. The function of the encoded protein has not been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.92597407
2sperm-egg recognition (GO:0035036)9.89533533
3multicellular organism reproduction (GO:0032504)9.67430847
4piRNA metabolic process (GO:0034587)9.59650531
5acrosome assembly (GO:0001675)9.51287924
6acrosome reaction (GO:0007340)9.43596290
7binding of sperm to zona pellucida (GO:0007339)9.05289773
8cell-cell recognition (GO:0009988)8.98013761
9epithelial cilium movement (GO:0003351)8.80320949
10motile cilium assembly (GO:0044458)8.55290779
11plasma membrane fusion (GO:0045026)8.33568736
12spermatid development (GO:0007286)8.28976947
13male meiosis (GO:0007140)8.01156027
14cell wall macromolecule catabolic process (GO:0016998)7.93417808
15cell wall macromolecule metabolic process (GO:0044036)7.93417808
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.85680117
17reproduction (GO:0000003)7.85626288
18cilium movement (GO:0003341)7.71495653
19synaptonemal complex organization (GO:0070193)7.31856480
20regulation of cilium movement (GO:0003352)7.21113400
21synaptonemal complex assembly (GO:0007130)7.10384310
22response to pheromone (GO:0019236)7.01126363
23single fertilization (GO:0007338)6.73735814
24sperm capacitation (GO:0048240)6.48923919
25male meiosis I (GO:0007141)6.06681744
26DNA methylation involved in gamete generation (GO:0043046)5.91559885
27fertilization (GO:0009566)5.82293220
28peptidyl-glutamic acid carboxylation (GO:0017187)5.81904600
29protein carboxylation (GO:0018214)5.81904600
30negative regulation of cell aging (GO:0090344)5.80256771
31cellular response to ATP (GO:0071318)5.62185162
32microtubule depolymerization (GO:0007019)5.54022493
33chromosome organization involved in meiosis (GO:0070192)5.44316496
34flavonoid metabolic process (GO:0009812)5.44186370
35spermatogenesis (GO:0007283)5.40425357
36male gamete generation (GO:0048232)5.38601211
37organic cation transport (GO:0015695)5.15912189
38GDP-mannose metabolic process (GO:0019673)5.10670001
39ventricular system development (GO:0021591)5.08535360
40meiotic nuclear division (GO:0007126)5.03809343
41negative regulation of inclusion body assembly (GO:0090084)5.02279843
42meiotic chromosome segregation (GO:0045132)5.00663184
43rRNA methylation (GO:0031167)4.97371455
44gamete generation (GO:0007276)4.94217471
45meiosis I (GO:0007127)4.92502339
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.88564971
47germ cell development (GO:0007281)4.81822550
48meiotic cell cycle (GO:0051321)4.77444353
49seminiferous tubule development (GO:0072520)4.75363864
50regulation of skeletal muscle contraction (GO:0014819)4.71328155
51cellular ketone body metabolic process (GO:0046950)4.45937116
52monoubiquitinated protein deubiquitination (GO:0035520)4.39418088
53DNA strand renaturation (GO:0000733)4.33179401
54gene silencing by RNA (GO:0031047)4.29844838
55melanin biosynthetic process (GO:0042438)4.19153349
56regulation of inclusion body assembly (GO:0090083)4.18075894
57ketone body metabolic process (GO:1902224)4.17153318
58detection of light stimulus involved in sensory perception (GO:0050962)4.07165714
59detection of light stimulus involved in visual perception (GO:0050908)4.07165714
60genitalia morphogenesis (GO:0035112)4.03410506
61regulation of synapse structural plasticity (GO:0051823)4.00872152
62NAD biosynthetic process (GO:0009435)4.00819986
63positive regulation of protein kinase C signaling (GO:0090037)3.99899827
64drug catabolic process (GO:0042737)3.99030203
65microtubule severing (GO:0051013)3.98100507
66rRNA modification (GO:0000154)3.96512587
67mitotic sister chromatid cohesion (GO:0007064)3.95889018
68cell recognition (GO:0008037)3.94091405
69mitotic cell cycle arrest (GO:0071850)3.91569371
70multicellular organismal reproductive process (GO:0048609)3.87926810
71nuclear pore complex assembly (GO:0051292)3.86870572
72tryptophan catabolic process (GO:0006569)3.86695369
73indole-containing compound catabolic process (GO:0042436)3.86695369
74indolalkylamine catabolic process (GO:0046218)3.86695369
75regulation of microtubule-based movement (GO:0060632)3.85613395
76left/right pattern formation (GO:0060972)3.85299634
77chromosome condensation (GO:0030261)3.83355020
78cellular glucuronidation (GO:0052695)3.81620697
79melanin metabolic process (GO:0006582)3.81588546
80lens fiber cell differentiation (GO:0070306)3.78846636
81pyridine nucleotide biosynthetic process (GO:0019363)3.78296839
82nicotinamide nucleotide biosynthetic process (GO:0019359)3.78296839
83DNA packaging (GO:0006323)3.76682369
84transepithelial transport (GO:0070633)3.74594989
85exogenous drug catabolic process (GO:0042738)3.67545413
86protein localization to cilium (GO:0061512)3.65673339
87sex differentiation (GO:0007548)3.65350161
88synapsis (GO:0007129)3.65291527
89estrogen biosynthetic process (GO:0006703)3.63940062
90nucleoside transmembrane transport (GO:1901642)3.60247526
91phosphatidylethanolamine biosynthetic process (GO:0006646)3.58702946
92meiotic cell cycle process (GO:1903046)3.57255410
93kynurenine metabolic process (GO:0070189)3.56933273
94secondary metabolite biosynthetic process (GO:0044550)3.56214792
95calcium ion-dependent exocytosis (GO:0017156)3.54349854
96regulation of centriole replication (GO:0046599)3.52383215
97bile acid biosynthetic process (GO:0006699)3.48610350
98behavioral response to nicotine (GO:0035095)3.47627514
99purinergic nucleotide receptor signaling pathway (GO:0035590)3.44575614
100response to phenylpropanoid (GO:0080184)3.43642167
101citrulline biosynthetic process (GO:0019240)3.43147013
102protein polyglutamylation (GO:0018095)3.42847343
103peristalsis (GO:0030432)3.40322542
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.38280306
105uronic acid metabolic process (GO:0006063)3.37142027
106glucuronate metabolic process (GO:0019585)3.37142027
107adenosine receptor signaling pathway (GO:0001973)3.33489791
108regulation of triglyceride catabolic process (GO:0010896)3.31720115
109carnitine transmembrane transport (GO:1902603)3.30493648
110purine ribonucleotide transport (GO:0015868)3.30396705
111amino-acid betaine transport (GO:0015838)3.30390106
112carnitine transport (GO:0015879)3.30390106
113regulation of cytokine production involved in inflammatory response (GO:1900015)3.27801240
114aromatic amino acid family catabolic process (GO:0009074)3.27508319
115negative regulation of organelle assembly (GO:1902116)3.26562362
116intestinal cholesterol absorption (GO:0030299)3.26319206
117sensory perception of taste (GO:0050909)3.26243238
118oligosaccharide catabolic process (GO:0009313)3.25894766
1193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.24969257
120purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.24969257
121regulation of spindle checkpoint (GO:0090231)3.21613787
122nuclear pore organization (GO:0006999)3.20860306
123imidazole-containing compound metabolic process (GO:0052803)3.20335235
124epoxygenase P450 pathway (GO:0019373)3.19570238
125drug metabolic process (GO:0017144)3.19511698
126glutathione derivative biosynthetic process (GO:1901687)3.18640667
127glutathione derivative metabolic process (GO:1901685)3.18640667
128regulation of histone H3-K9 methylation (GO:0051570)3.17835781
129phenylpropanoid metabolic process (GO:0009698)3.16445361
130peptidyl-glutamic acid modification (GO:0018200)3.15713806
131phosphatidylethanolamine metabolic process (GO:0046337)3.15451949
132gene silencing (GO:0016458)3.14465921
133alkaloid metabolic process (GO:0009820)3.14279850
134pseudouridine synthesis (GO:0001522)3.11679837
135chaperone-mediated protein complex assembly (GO:0051131)3.11591752
136multicellular organismal development (GO:0007275)3.10618453
137bile acid and bile salt transport (GO:0015721)3.09151032
138pore complex assembly (GO:0046931)3.06243187
139androgen biosynthetic process (GO:0006702)3.06156482
140one-carbon compound transport (GO:0019755)3.04735612
141triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.03632931
142urinary tract smooth muscle contraction (GO:0014848)2.97956597
143protein localization to chromosome, centromeric region (GO:0071459)2.97470246
144RNA localization (GO:0006403)2.93790941
145sex determination (GO:0007530)2.93195056
146sphingoid metabolic process (GO:0046519)2.92611460
147bile acid metabolic process (GO:0008206)2.92272311
148centriole replication (GO:0007099)2.91448509
149glycerol ether metabolic process (GO:0006662)2.91407985
150translesion synthesis (GO:0019985)2.90719499
151negative regulation of DNA repair (GO:0045738)2.89327295
152aromatic amino acid family metabolic process (GO:0009072)2.89094716
153centriole assembly (GO:0098534)2.88209478
154pyridine-containing compound biosynthetic process (GO:0072525)2.88139353
155regulation of meiosis I (GO:0060631)2.87975185
156response to nitrosative stress (GO:0051409)2.87350830
157intraciliary transport (GO:0042073)2.87094156
158tryptophan metabolic process (GO:0006568)2.86863278
159amino-acid betaine metabolic process (GO:0006577)2.84657452
160positive regulation of lipoprotein lipase activity (GO:0051006)2.84417456
161positive regulation of triglyceride lipase activity (GO:0061365)2.84417456
162regulation of phospholipid biosynthetic process (GO:0071071)2.83333699
163negative regulation of Rho protein signal transduction (GO:0035024)2.81340811
164microtubule-based movement (GO:0007018)2.80883742
165nucleotide transmembrane transport (GO:1901679)2.80453568
166L-phenylalanine metabolic process (GO:0006558)2.80143034
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80143034
168indolalkylamine metabolic process (GO:0006586)2.79318308
169glyoxylate metabolic process (GO:0046487)2.79314546
170heme transport (GO:0015886)2.78675126
171regulation of acrosome reaction (GO:0060046)2.78560726
172sister chromatid cohesion (GO:0007062)2.78495044
173regulation of memory T cell differentiation (GO:0043380)2.78159582
174phosphatidylcholine biosynthetic process (GO:0006656)2.78033732
175nucleus organization (GO:0006997)2.77336004
176spermatid nucleus differentiation (GO:0007289)2.75370583
177histone exchange (GO:0043486)2.74672766
178axoneme assembly (GO:0035082)2.74669020
179ether metabolic process (GO:0018904)2.66086096
180DNA methylation (GO:0006306)2.63957036
181DNA alkylation (GO:0006305)2.63957036
182cilium organization (GO:0044782)2.60034839
183microtubule polymerization or depolymerization (GO:0031109)2.58783646
184regulation of RNA export from nucleus (GO:0046831)2.56475307
185regulation of protein polyubiquitination (GO:1902914)2.52272822
186DNA replication-dependent nucleosome organization (GO:0034723)2.52255683
187DNA replication-dependent nucleosome assembly (GO:0006335)2.52255683
188alditol metabolic process (GO:0019400)2.51904206
189positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49720727
190cilium or flagellum-dependent cell motility (GO:0001539)13.8349268
191fusion of sperm to egg plasma membrane (GO:0007342)11.2440899
192sperm motility (GO:0030317)11.0478675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.79768916
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.43343421
3EZH2_22144423_ChIP-Seq_EOC_Human3.33940051
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29477293
5P68_20966046_ChIP-Seq_HELA_Human2.88621966
6E2F1_20622854_ChIP-Seq_HELA_Human2.68690157
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61846348
8VDR_21846776_ChIP-Seq_THP-1_Human2.60847645
9LXR_22292898_ChIP-Seq_THP-1_Human2.58660301
10CTCF_27219007_Chip-Seq_Bcells_Human2.51187342
11BCL6_27268052_Chip-Seq_Bcells_Human2.48482738
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.46238301
13PHF8_20622854_ChIP-Seq_HELA_Human2.44983416
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38125960
15BCOR_27268052_Chip-Seq_Bcells_Human2.37984405
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36210714
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27844171
18E2F7_22180533_ChIP-Seq_HELA_Human2.27026251
19SMC4_20622854_ChIP-Seq_HELA_Human2.26285085
20CTCF_20526341_ChIP-Seq_ESCs_Human2.24782962
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20062461
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16399538
23SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.14375300
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.13401357
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09294557
26YY1_22570637_ChIP-Seq_MALME-3M_Human2.06216300
27ERA_21632823_ChIP-Seq_H3396_Human2.04574609
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9596086
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.98807060
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.97081487
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.96614181
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92297848
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.90334275
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.89125867
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88640414
36RACK7_27058665_Chip-Seq_MCF-7_Human1.88631864
37MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.85976176
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83994278
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.83902092
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83795281
41CTCF_21964334_Chip-Seq_Bcells_Human1.82772577
42NANOG_20526341_ChIP-Seq_ESCs_Human1.82655949
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79942186
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79197312
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79055433
46RARB_24833708_ChIP-Seq_LIVER_Mouse1.74998099
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73479886
48TP63_22573176_ChIP-Seq_HFKS_Human1.73226327
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.71105187
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71072379
51TAF2_19829295_ChIP-Seq_ESCs_Human1.70240776
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70071730
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.67687581
54RAC3_21632823_ChIP-Seq_H3396_Human1.64937425
55P300_27268052_Chip-Seq_Bcells_Human1.64368834
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62951564
57SA1_27219007_Chip-Seq_Bcells_Human1.61942675
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61635683
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.61003823
60MYC_19829295_ChIP-Seq_ESCs_Human1.60129686
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56347129
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.56291308
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55903803
64FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55009340
65MAF_26560356_Chip-Seq_TH2_Human1.54996483
66STAT1_17558387_ChIP-Seq_HELA_Human1.52511075
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51946310
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51620569
69OCT4_20526341_ChIP-Seq_ESCs_Human1.50189638
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.50033464
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48037340
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45377364
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45357504
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43044827
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42301619
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40466305
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39463666
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38789810
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36116254
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.35299243
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34904280
82XRN2_22483619_ChIP-Seq_HELA_Human1.34744570
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32483176
84NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.29734959
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.28209322
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28113081
87FOXP1_21924763_ChIP-Seq_HESCs_Human1.27136342
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25497763
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25455710
90JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24705902
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.24454375
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23828367
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.22302768
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22046629
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20309784
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.20037099
97ZNF274_21170338_ChIP-Seq_K562_Hela1.18769588
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18688405
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18688405
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.16754983
101GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.16236148
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16214544
103CREB1_26743006_Chip-Seq_LNCaP_Human1.16176311
104CBP_20019798_ChIP-Seq_JUKART_Human1.15325994
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15325994
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14895693
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14558013
108GATA3_21867929_ChIP-Seq_CD8_Mouse1.14358659
109SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14043037
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13899687
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13845824
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13428538
113SOX2_21211035_ChIP-Seq_LN229_Human1.13170629
114DROSHA_22980978_ChIP-Seq_HELA_Human1.12175680
115P53_21459846_ChIP-Seq_SAOS-2_Human1.11793780
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10982322
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.10390449
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09907362
119RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07760036
120GATA3_21867929_ChIP-Seq_TH1_Mouse1.06310539
121KDM2B_26808549_Chip-Seq_REH_Human1.06066798
122FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04843331
123SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03956075
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03183610
125GATA3_21878914_ChIP-Seq_MCF-7_Human1.03132271
126SALL1_21062744_ChIP-ChIP_HESCs_Human1.03116340
127NCOR_22424771_ChIP-Seq_293T_Human1.02868305
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02301616
129ATF3_27146783_Chip-Seq_COLON_Human1.01951736
130CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01648723
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01601742
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01530115
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.00924815
134ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99979817
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.99223283
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99175085
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99068458
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98589786
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98234546
140SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98026628
141GF1_26923725_Chip-Seq_HPCs_Mouse0.97857330
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97853452
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97177785
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97173653
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96332232
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.96104226
147GATA6_25053715_ChIP-Seq_YYC3_Human0.95910979
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95566352
149VDR_24763502_ChIP-Seq_THP-1_Human0.95515352
150OCT4_19829295_ChIP-Seq_ESCs_Human0.95426188
151KLF4_19829295_ChIP-Seq_ESCs_Human0.95351492
152VDR_22108803_ChIP-Seq_LS180_Human0.94867642
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93857432
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.93726486
155NFYB_21822215_ChIP-Seq_K562_Human0.93383647
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.92829494
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92047353
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91196443
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90798650
160P53_22387025_ChIP-Seq_ESCs_Mouse0.90790583
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.90424507
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89298722
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88188183
164BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87615611
165P300_18555785_Chip-Seq_ESCs_Mouse0.87498648
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.87492713
167EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86579213
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.86481706
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.86135269
170PU1_27457419_Chip-Seq_LIVER_Mouse0.85784018
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85636949
172TBL1_22424771_ChIP-Seq_293T_Human0.85543138
173RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84991689
174MYB_26560356_Chip-Seq_TH1_Human0.84816633
175CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84577001
176NANOG_18555785_Chip-Seq_ESCs_Mouse0.82966302
177ERG_20517297_ChIP-Seq_VCAP_Human0.82683470
178GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81886607
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81520461
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.80900185
181SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80680933
182FLI1_21867929_ChIP-Seq_TH2_Mouse0.79507709
183RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79199563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.52740535
2MP0005171_absent_coat_pigmentation5.42025283
3MP0003698_abnormal_male_reproductive5.17280834
4MP0001929_abnormal_gametogenesis4.94777544
5MP0008877_abnormal_DNA_methylation4.22283657
6MP0001986_abnormal_taste_sensitivity4.20946730
7MP0002210_abnormal_sex_determination3.48320569
8MP0001145_abnormal_male_reproductive2.98189634
9MP0005423_abnormal_somatic_nervous2.89173980
10MP0002161_abnormal_fertility/fecundity2.86468619
11MP0002139_abnormal_hepatobiliary_system2.86204555
12MP0000566_synostosis2.84702249
13MP0000653_abnormal_sex_gland2.58720365
14MP0001968_abnormal_touch/_nociception2.52424338
15MP0002653_abnormal_ependyma_morphology2.45889383
16MP0010094_abnormal_chromosome_stability2.41379191
17MP0002736_abnormal_nociception_after2.37914793
18MP0003806_abnormal_nucleotide_metabolis2.05552632
19MP0008057_abnormal_DNA_replication2.03829431
20MP0001661_extended_life_span2.03287298
21MP0005410_abnormal_fertilization13.1149311
22MP0005623_abnormal_meninges_morphology1.99201417
23MP0008058_abnormal_DNA_repair1.92395043
24MP0003195_calcinosis1.88615459
25MP0005332_abnormal_amino_acid1.84858146
26MP0002160_abnormal_reproductive_system1.81617616
27MP0005670_abnormal_white_adipose1.79880811
28MP0003111_abnormal_nucleus_morphology1.78948719
29MP0004043_abnormal_pH_regulation1.72495171
30MP0005360_urolithiasis1.70905799
31MP0009278_abnormal_bone_marrow1.64789214
32MP0000569_abnormal_digit_pigmentation1.63780470
33MP0005551_abnormal_eye_electrophysiolog1.57016541
34MP0004381_abnormal_hair_follicle1.54973066
35MP0010307_abnormal_tumor_latency1.53110847
36MP0005365_abnormal_bile_salt1.51607465
37MP0003252_abnormal_bile_duct1.51149458
38MP0001666_abnormal_nutrient_absorption1.49776017
39MP0001664_abnormal_digestion1.47725883
40MP0001756_abnormal_urination1.47628025
41MP0004130_abnormal_muscle_cell1.47282643
42MP0000678_abnormal_parathyroid_gland1.46280669
43MP0002638_abnormal_pupillary_reflex1.46129201
44MP0005085_abnormal_gallbladder_physiolo1.41200253
45MP0004808_abnormal_hematopoietic_stem1.33077293
46MP0001545_abnormal_hematopoietic_system1.32602611
47MP0005397_hematopoietic_system_phenotyp1.32602611
48MP0000538_abnormal_urinary_bladder1.32019226
49MP0005647_abnormal_sex_gland1.27858257
50MP0002249_abnormal_larynx_morphology1.27403515
51MP0003718_maternal_effect1.26463654
52MP0005409_darkened_coat_color1.24571238
53MP0002282_abnormal_trachea_morphology1.20663306
54MP0010386_abnormal_urinary_bladder1.18393979
55MP0008007_abnormal_cellular_replicative1.18368967
56MP0003693_abnormal_embryo_hatching1.16645180
57MP0003077_abnormal_cell_cycle1.14691569
58MP0002928_abnormal_bile_duct1.12438261
59MP0009643_abnormal_urine_homeostasis1.11260505
60MP0001188_hyperpigmentation1.11188698
61MP0002138_abnormal_hepatobiliary_system1.08275463
62MP0009840_abnormal_foam_cell1.04809056
63MP0005584_abnormal_enzyme/coenzyme_acti1.04786047
64MP0008872_abnormal_physiological_respon1.02770483
65MP0009053_abnormal_anal_canal1.01996879
66MP0005389_reproductive_system_phenotype0.99427194
67MP0002735_abnormal_chemical_nociception0.98647294
68MP0000750_abnormal_muscle_regeneration0.97130842
69MP0008995_early_reproductive_senescence0.95578239
70MP0001502_abnormal_circadian_rhythm0.94986619
71MP0000470_abnormal_stomach_morphology0.93144325
72MP0001873_stomach_inflammation0.92547902
73MP0005501_abnormal_skin_physiology0.92125286
74MP0005174_abnormal_tail_pigmentation0.92080872
75MP0000516_abnormal_urinary_system0.91180509
76MP0005367_renal/urinary_system_phenotyp0.91180509
77MP0008875_abnormal_xenobiotic_pharmacok0.89781496
78MP0005330_cardiomyopathy0.89618127
79MP0000371_diluted_coat_color0.87406591
80MP0003315_abnormal_perineum_morphology0.83008156
81MP0003786_premature_aging0.81872080
82MP0001485_abnormal_pinna_reflex0.80382720
83MP0004185_abnormal_adipocyte_glucose0.79783101
84MP0000026_abnormal_inner_ear0.79065684
85MP0003646_muscle_fatigue0.77378058
86MP0005253_abnormal_eye_physiology0.76176430
87MP0000367_abnormal_coat/_hair0.75279478
88MP0000751_myopathy0.74760578
89MP0002396_abnormal_hematopoietic_system0.74128016
90MP0009046_muscle_twitch0.72474007
91MP0003868_abnormal_feces_composition0.71836317
92MP0001293_anophthalmia0.71167870
93MP0010329_abnormal_lipoprotein_level0.69804503
94MP0003879_abnormal_hair_cell0.69612644
95MP0001765_abnormal_ion_homeostasis0.69581245
96MP0005395_other_phenotype0.67957148
97MP0001764_abnormal_homeostasis0.67646563
98MP0010771_integument_phenotype0.66687237
99MP0003453_abnormal_keratinocyte_physiol0.66440279
100MP0003699_abnormal_female_reproductive0.66000155
101MP0005083_abnormal_biliary_tract0.65655702
102MP0000609_abnormal_liver_physiology0.65095412
103MP0001119_abnormal_female_reproductive0.63941404
104MP0004019_abnormal_vitamin_homeostasis0.62695574
105MP0003011_delayed_dark_adaptation0.61890220
106MP0000313_abnormal_cell_death0.61764972
107MP0001963_abnormal_hearing_physiology0.60998262
108MP0005666_abnormal_adipose_tissue0.59960077
109MP0002234_abnormal_pharynx_morphology0.59631842
110MP0003137_abnormal_impulse_conducting0.58777563
111MP0000703_abnormal_thymus_morphology0.58439108
112MP0001730_embryonic_growth_arrest0.57845396
113MP0001324_abnormal_eye_pigmentation0.57684646
114MP0002095_abnormal_skin_pigmentation0.57239936
115MP0003115_abnormal_respiratory_system0.57231424
116MP0002405_respiratory_system_inflammati0.56442974
117MP0002398_abnormal_bone_marrow0.56003106
118MP0004957_abnormal_blastocyst_morpholog0.55193879
119MP0002102_abnormal_ear_morphology0.54790891
120MP0000358_abnormal_cell_content/0.54728529
121MP0005380_embryogenesis_phenotype0.54195378
122MP0001672_abnormal_embryogenesis/_devel0.54195378
123MP0003638_abnormal_response/metabolism_0.54052084
124MP0003878_abnormal_ear_physiology0.53715939
125MP0005377_hearing/vestibular/ear_phenot0.53715939
126MP0009115_abnormal_fat_cell0.52641360
127MP0000427_abnormal_hair_cycle0.52327342
128MP0003763_abnormal_thymus_physiology0.52213091
129MP0002092_abnormal_eye_morphology0.51000301
130MP0002075_abnormal_coat/hair_pigmentati0.50706902
131MP0000467_abnormal_esophagus_morphology0.49324987
132MP0002136_abnormal_kidney_physiology0.49096991
133MP0002019_abnormal_tumor_incidence0.48417642
134MP0005076_abnormal_cell_differentiation0.47812394
135MP0003984_embryonic_growth_retardation0.45544929
136MP0000689_abnormal_spleen_morphology0.45199064
137MP0006082_CNS_inflammation0.44819500
138MP0002088_abnormal_embryonic_growth/wei0.43906374
139MP0000490_abnormal_crypts_of0.43454568
140MP0001984_abnormal_olfaction0.43430879
141MP0009697_abnormal_copulation0.43153019
142MP0005636_abnormal_mineral_homeostasis0.43048026
143MP0009672_abnormal_birth_weight0.40975418
144MP0001800_abnormal_humoral_immune0.40539361
145MP0008961_abnormal_basal_metabolism0.40199685
146MP0000685_abnormal_immune_system0.39992567
147MP0003943_abnormal_hepatobiliary_system0.39916377
148MP0004264_abnormal_extraembryonic_tissu0.38674904
149MP0000598_abnormal_liver_morphology0.38328473
150MP0001727_abnormal_embryo_implantation0.38292261
151MP0005464_abnormal_platelet_physiology0.37984466
152MP0005319_abnormal_enzyme/_coenzyme0.37739721
153MP0000015_abnormal_ear_pigmentation0.37573083
154MP0002971_abnormal_brown_adipose0.37013386
155MP0004197_abnormal_fetal_growth/weight/0.36760559
156MP0000350_abnormal_cell_proliferation0.36559653
157MP0002722_abnormal_immune_system0.36194425
158MP0002132_abnormal_respiratory_system0.35355916
159MP0003300_gastrointestinal_ulcer0.35090427
160MP0002723_abnormal_immune_serum0.34692546
161MP0000716_abnormal_immune_system0.33751527
162MP0002429_abnormal_blood_cell0.33539656
163MP0002118_abnormal_lipid_homeostasis0.33431864

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.59121303
2Abnormal respiratory motile cilium morphology (HP:0005938)8.05041062
3Abnormal respiratory epithelium morphology (HP:0012253)8.05041062
4Rhinitis (HP:0012384)7.40540560
5Abnormal ciliary motility (HP:0012262)6.75516997
6Attenuation of retinal blood vessels (HP:0007843)6.48646107
7Nasal polyposis (HP:0100582)6.48093940
8Chronic bronchitis (HP:0004469)6.33726442
9Infertility (HP:0000789)5.80817516
10Abnormality of the nasal mucosa (HP:0000433)5.29928923
11Congenital stationary night blindness (HP:0007642)4.95349382
12Rib fusion (HP:0000902)4.93099138
13Prolonged partial thromboplastin time (HP:0003645)4.82680182
14Bronchiectasis (HP:0002110)4.75467448
15Testicular atrophy (HP:0000029)4.53435321
16Bronchitis (HP:0012387)4.51305823
17Nephronophthisis (HP:0000090)4.48650888
18Poikiloderma (HP:0001029)4.29296401
19Bony spicule pigmentary retinopathy (HP:0007737)3.84479699
20Abnormality of the intrinsic pathway (HP:0010989)3.82080500
21Popliteal pterygium (HP:0009756)3.80192943
22Recurrent sinusitis (HP:0011108)3.65527328
23Abnormal spermatogenesis (HP:0008669)3.64670771
24Recurrent otitis media (HP:0000403)3.59943356
25Rectal fistula (HP:0100590)3.51558518
26Rectovaginal fistula (HP:0000143)3.51558518
27Abnormality of the renal medulla (HP:0100957)3.48965712
28Coronal craniosynostosis (HP:0004440)3.48725418
29Joint hemorrhage (HP:0005261)3.46871055
30Mesangial abnormality (HP:0001966)3.36904327
31Facial diplegia (HP:0001349)3.36114992
32Vaginal fistula (HP:0004320)3.33865363
33Recurrent bronchitis (HP:0002837)3.29692077
34Genetic anticipation (HP:0003743)3.26600697
35Hypobetalipoproteinemia (HP:0003563)3.22970076
36Male infertility (HP:0003251)3.21988358
37Impulsivity (HP:0100710)3.20584393
38Intestinal fistula (HP:0100819)3.15970987
39Abnormality of pyrimidine metabolism (HP:0004353)3.14820554
40Thin bony cortex (HP:0002753)3.13580148
41Akinesia (HP:0002304)3.11726404
42Decreased electroretinogram (ERG) amplitude (HP:0000654)3.11082811
43Hypophosphatemic rickets (HP:0004912)3.09567142
44Abnormality of the costochondral junction (HP:0000919)3.05709384
45Tubulointerstitial nephritis (HP:0001970)3.05609462
46Facial hemangioma (HP:0000329)3.01791533
47Azoospermia (HP:0000027)3.00058332
48Absent radius (HP:0003974)2.97191339
49Abnormality of the lower motor neuron (HP:0002366)2.96630244
50Absent thumb (HP:0009777)2.92196157
51Annular pancreas (HP:0001734)2.86022893
52Gonadotropin excess (HP:0000837)2.84973294
53Enlarged epiphyses (HP:0010580)2.83320663
54Aplasia involving forearm bones (HP:0009822)2.81441186
55Absent forearm bone (HP:0003953)2.81441186
56Patellar aplasia (HP:0006443)2.80898245
57Aplasia of the musculature (HP:0100854)2.79768052
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72576454
59Birth length less than 3rd percentile (HP:0003561)2.72522238
60Pendular nystagmus (HP:0012043)2.71236634
61Decreased central vision (HP:0007663)2.71082520
62Global brain atrophy (HP:0002283)2.69046724
63Abnormal biliary tract physiology (HP:0012439)2.69019988
64Bile duct proliferation (HP:0001408)2.69019988
65Severe visual impairment (HP:0001141)2.63465499
66Aplasia/Hypoplasia of the patella (HP:0006498)2.63090954
67Heterotopia (HP:0002282)2.61481552
68Tubular atrophy (HP:0000092)2.59769309
69Duplicated collecting system (HP:0000081)2.59153474
70Chorioretinal atrophy (HP:0000533)2.57460815
71Abnormality of the common coagulation pathway (HP:0010990)2.54502268
72Abnormality of the hepatic vasculature (HP:0006707)2.53576260
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.51131799
74Decreased circulating renin level (HP:0003351)2.48037637
75Tubulointerstitial abnormality (HP:0001969)2.47919389
76Ulnar bowing (HP:0003031)2.46156164
77Cholecystitis (HP:0001082)2.45597657
78Abnormal gallbladder physiology (HP:0012438)2.45597657
79Renal Fanconi syndrome (HP:0001994)2.45112029
80Abnormality of DNA repair (HP:0003254)2.39275466
81Breast hypoplasia (HP:0003187)2.38415309
82Abnormality of the renal collecting system (HP:0004742)2.36834923
83Chromsome breakage (HP:0040012)2.36130325
84Tinnitus (HP:0000360)2.35650088
85Delayed epiphyseal ossification (HP:0002663)2.34993978
86Choroideremia (HP:0001139)2.34555368
87Generalized aminoaciduria (HP:0002909)2.33642980
88Esophageal neoplasm (HP:0100751)2.33103316
89Neoplasm of head and neck (HP:0012288)2.33103316
90Molar tooth sign on MRI (HP:0002419)2.30043169
91Abnormality of midbrain morphology (HP:0002418)2.30043169
92Turricephaly (HP:0000262)2.26795557
93Squamous cell carcinoma (HP:0002860)2.26363395
94Atrioventricular block (HP:0001678)2.23126134
95Widely patent fontanelles and sutures (HP:0004492)2.22978876
96Short thumb (HP:0009778)2.19539656
97Absent frontal sinuses (HP:0002688)2.19157776
98Lipid accumulation in hepatocytes (HP:0006561)2.14481470
99Hypolipoproteinemia (HP:0010981)2.14303645
100Impaired proprioception (HP:0010831)2.08979428
101Impaired smooth pursuit (HP:0007772)2.08308987
102Fibular hypoplasia (HP:0003038)2.06892197
103Postaxial foot polydactyly (HP:0001830)2.06560878
104Abnormality of the renal cortex (HP:0011035)2.06533764
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.04611784
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01300017
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01249098
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9106200
109Absent/shortened dynein arms (HP:0200106)11.5648811
110Dynein arm defect of respiratory motile cilia (HP:0012255)11.5648811
111Congenital hepatic fibrosis (HP:0002612)1.99356111
112Respiratory distress (HP:0002098)1.98017288
113Progressive cerebellar ataxia (HP:0002073)1.96755244
114Supernumerary spleens (HP:0009799)1.94645895
115Macular degeneration (HP:0000608)1.94269865
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93059717
117Short ribs (HP:0000773)1.92967844
118Upper motor neuron abnormality (HP:0002127)1.88622998
119Amniotic constriction ring (HP:0009775)1.87083302
120Abnormality of placental membranes (HP:0011409)1.87083302
121Spontaneous abortion (HP:0005268)1.86065882
122Diminished movement (HP:0002374)1.84899529
123Hyperlipoproteinemia (HP:0010980)1.84534567
124Increased hepatocellular lipid droplets (HP:0006565)1.83281148
125Stage 5 chronic kidney disease (HP:0003774)1.83278439
126Tubulointerstitial fibrosis (HP:0005576)1.83156808
127Dysmetric saccades (HP:0000641)1.83060976
128Short chin (HP:0000331)1.83025518
129Amyotrophic lateral sclerosis (HP:0007354)1.83006730
130Urinary glycosaminoglycan excretion (HP:0003541)1.80389560
131Mucopolysacchariduria (HP:0008155)1.80389560
132Hypoplasia of the radius (HP:0002984)1.80222277
133Increased number of teeth (HP:0011069)1.78050617
134Renovascular hypertension (HP:0100817)1.77379071
135Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76922098
136Hypoalbuminemia (HP:0003073)1.76109497
137Abnormal albumin level (HP:0012116)1.76109497
138Flat occiput (HP:0005469)1.74400108
139Abnormality of the labia majora (HP:0012881)1.74217481
140Spastic tetraparesis (HP:0001285)1.73626226
141Premature graying of hair (HP:0002216)1.73484907
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67967105
143Renal dysplasia (HP:0000110)1.67122224
144Deformed sella turcica (HP:0002681)1.66819678
145Chronic sinusitis (HP:0011109)1.63654807
146Ectopic kidney (HP:0000086)1.60178092
147Oculomotor apraxia (HP:0000657)1.58721923
148Medial flaring of the eyebrow (HP:0010747)1.55361896
149Truncal obesity (HP:0001956)1.53991109
150High pitched voice (HP:0001620)1.53824469
151J-shaped sella turcica (HP:0002680)1.53459362
152Sloping forehead (HP:0000340)1.52933609
153Absent epiphyses (HP:0010577)1.51791128
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51791128
155Hemorrhage of the eye (HP:0011885)1.51728402
156Abnormality of chromosome stability (HP:0003220)1.51296276
157Microglossia (HP:0000171)1.50345502
158Short thorax (HP:0010306)1.49124060
159Selective tooth agenesis (HP:0001592)1.47562136
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.46459905
161Dyschromatopsia (HP:0007641)1.45763616
162Bell-shaped thorax (HP:0001591)1.45739010
163Median cleft lip (HP:0000161)1.45297918
164Facial cleft (HP:0002006)1.45211743
165Conjunctival telangiectasia (HP:0000524)1.44762175
166Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.42837659
167Hypercholesterolemia (HP:0003124)1.40444270
168Polydipsia (HP:0001959)1.40095436
169Abnormal drinking behavior (HP:0030082)1.40095436
170Chromosomal breakage induced by crosslinking agents (HP:0003221)1.40034402
171Abnormality of the dental root (HP:0006486)1.39728393
172Taurodontia (HP:0000679)1.39728393
173Abnormality of permanent molar morphology (HP:0011071)1.39728393
174Acanthocytosis (HP:0001927)1.39719835
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.39196093
176Cystic liver disease (HP:0006706)1.38154615
177Degeneration of anterior horn cells (HP:0002398)1.38085059
178Abnormality of the anterior horn cell (HP:0006802)1.38085059
179Abnormality of the carotid arteries (HP:0005344)1.33615422
180Abnormality of molar (HP:0011077)1.33615012
181Abnormality of molar morphology (HP:0011070)1.33615012
182Nephroblastoma (Wilms tumor) (HP:0002667)1.33421084
183Vascular calcification (HP:0004934)1.30394206
184Meckel diverticulum (HP:0002245)1.29923037
185Abnormality of the preputium (HP:0100587)1.28569453
186Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.27014772
187Broad distal phalanx of finger (HP:0009836)1.26234379
18811 pairs of ribs (HP:0000878)1.25335331
189Prominent nose (HP:0000448)1.25153949
190Abnormality of the ileum (HP:0001549)1.24787380
191Postaxial hand polydactyly (HP:0001162)1.24729906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.41773770
2PDK47.41773770
3TESK14.78233853
4PDK24.54656899
5PRKD34.04413759
6ICK3.79752915
7EPHA23.18338727
8NEK23.02985818
9ACVR1B3.02090135
10MST1R2.96737051
11GRK12.76736304
12STK32.70272180
13ADRBK22.62275292
14MUSK2.57523829
15FRK2.56388978
16CAMKK22.54428491
17MET2.26121711
18PTK2B2.19400560
19CDC71.93269680
20PNCK1.90077316
21ADRBK11.88972959
22OXSR11.83459967
23WNK41.74926830
24DDR21.71793734
25BLK1.69752690
26TTK1.69466454
27RPS6KB21.66862738
28TGFBR11.59513848
29MAP4K21.57466849
30STK391.51465244
31MAPKAPK31.51036280
32EEF2K1.45914422
33MAP3K121.43315236
34CDK121.40133709
35STK381.33046543
36MAP3K21.32467472
37NME21.30673604
38DYRK1B1.30180434
39PBK1.29216313
40TLK11.25414876
41NTRK31.16654909
42CAMKK11.13416197
43FGFR31.12684041
44STK161.12541192
45WNK11.10814467
46MELK1.10207667
47DYRK31.07827772
48WEE11.07610609
49ATR1.06907644
50MAP2K11.06537610
51MAP3K101.05059847
52TRIB31.00919533
53MAPK150.97999364
54CAMK1G0.96788400
55SIK10.96078972
56ZAK0.96033944
57CCNB10.95107927
58PASK0.94983304
59SIK20.94478470
60MAP4K10.93787947
61STK100.90771886
62EPHB20.90186238
63CHEK10.85191544
64CDK40.83862918
65CHEK20.81028413
66DAPK20.76476112
67MAP2K20.76238205
68GRK50.75884646
69BRSK20.74900930
70PDK10.73819032
71ABL20.73790448
72MTOR0.71680444
73KSR20.71431098
74CDK60.69500779
75ATM0.69292970
76PLK10.68329352
77SCYL20.66122456
78PRKD20.65854090
79MAP3K10.56658759
80PLK40.54458327
81STK40.53806128
82GRK60.51440645
83TAOK30.51220451
84SRPK10.50864727
85NME10.49865286
86CSF1R0.48121514
87RPS6KA60.48011608
88TYRO30.47904586
89ZAP700.47022155
90TXK0.44513385
91PTK60.44293544
92CDK70.43740851
93BRD40.43681247
94CDK190.43094517
95DYRK20.42768103
96RIPK10.42728650
97KIT0.42112806
98PKN20.41891080
99PRKD10.41227842
100DAPK10.40815571
101IKBKB0.40180971
102AURKB0.39581686
103AURKA0.39287294
104BCKDK0.38378851
105FLT30.38086320
106PIM10.38026497
107LATS10.36862837
108CSK0.35776370
109STK240.34413668
110BMPR1B0.34269552
111PRKAA10.33651606
112IRAK10.33606631
113PAK20.33139690
114MYLK0.32387777
115MAP3K90.31544260
116MAP2K60.31265439
117PAK10.30921989
118TBK10.30842679
119PIK3CG0.29775726
120MARK30.29423443
121CDK20.27777490
122MAPKAPK50.26913826
123NTRK10.25375811
124TAOK10.24629847
125CDK90.24530486
126CAMK40.24217912
127CDK10.23883534
128RPS6KB10.22876756
129MAPK110.21125891
130CLK10.20569087
131STK38L0.20439601
132MAP3K80.18732105
133BMX0.18680400
134MAP3K70.18340576
135INSRR0.18334508
136CAMK10.18219680
137BUB10.17888329
138CDK11A0.17885497
139CSNK1D0.17721598
140MAP3K30.17546520
141MARK20.17465241
142EIF2AK20.17069804
143PDGFRB0.16751491
144CDK150.16645191
145LMTK20.15912091
146PRKCQ0.15731929
147ERN10.15488674
148BTK0.15421350
149TYK20.14493387
150MAPK10.14444632
151GSK3B0.13368659
152YES10.12788971
153PDPK10.12670409
154RPS6KA40.12257974
155CAMK1D0.12043849
156BRSK10.12019186
157PRKAA20.11036302
158PRKDC0.10179975
159HCK0.10159059
160MAPK140.10141971
161EIF2AK10.09423128
162MAP2K30.09312871
163TESK20.09047579

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.30959694
2Sulfur relay system_Homo sapiens_hsa041223.36644937
3Vitamin B6 metabolism_Homo sapiens_hsa007503.32965184
4Fanconi anemia pathway_Homo sapiens_hsa034603.28484701
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.17289135
6Selenocompound metabolism_Homo sapiens_hsa004503.12120904
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.02181102
8Pyruvate metabolism_Homo sapiens_hsa006202.86176934
9Fatty acid biosynthesis_Homo sapiens_hsa000612.79372677
10Propanoate metabolism_Homo sapiens_hsa006402.56007411
11Pentose phosphate pathway_Homo sapiens_hsa000302.34991758
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23377583
13Dorso-ventral axis formation_Homo sapiens_hsa043202.23316457
14Glucagon signaling pathway_Homo sapiens_hsa049222.09365322
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07006550
16Basal transcription factors_Homo sapiens_hsa030222.01865451
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97875604
18ABC transporters_Homo sapiens_hsa020101.87825358
19PPAR signaling pathway_Homo sapiens_hsa033201.86828326
20Linoleic acid metabolism_Homo sapiens_hsa005911.86073256
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.83231280
22Butanoate metabolism_Homo sapiens_hsa006501.80241668
23Glycerolipid metabolism_Homo sapiens_hsa005611.76865526
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74318125
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69109604
26Phenylalanine metabolism_Homo sapiens_hsa003601.68130170
27Homologous recombination_Homo sapiens_hsa034401.64459192
28Sphingolipid metabolism_Homo sapiens_hsa006001.59665163
29Other glycan degradation_Homo sapiens_hsa005111.59409042
30mRNA surveillance pathway_Homo sapiens_hsa030151.58562739
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57837484
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53201063
33Fatty acid degradation_Homo sapiens_hsa000711.52371267
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46575043
35Tyrosine metabolism_Homo sapiens_hsa003501.46061979
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.42734273
37Oocyte meiosis_Homo sapiens_hsa041141.37353192
38RNA transport_Homo sapiens_hsa030131.36365259
39Systemic lupus erythematosus_Homo sapiens_hsa053221.32083282
40Lysine degradation_Homo sapiens_hsa003101.31905211
41Fat digestion and absorption_Homo sapiens_hsa049751.29452763
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26385149
43Taste transduction_Homo sapiens_hsa047421.25824888
44Cell cycle_Homo sapiens_hsa041101.23719835
45Complement and coagulation cascades_Homo sapiens_hsa046101.23623479
46Phototransduction_Homo sapiens_hsa047441.23472614
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.21920669
48DNA replication_Homo sapiens_hsa030301.19827748
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19667222
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19221650
51Fatty acid metabolism_Homo sapiens_hsa012121.16037429
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15924770
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13101720
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12534058
55Antigen processing and presentation_Homo sapiens_hsa046121.10247543
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10194909
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10011411
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08259073
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.05768060
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03938864
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03389102
62Carbon metabolism_Homo sapiens_hsa012001.01495308
63Chemical carcinogenesis_Homo sapiens_hsa052040.99358238
64One carbon pool by folate_Homo sapiens_hsa006700.98583748
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.98428487
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97650723
67Non-homologous end-joining_Homo sapiens_hsa034500.96965635
68Fructose and mannose metabolism_Homo sapiens_hsa000510.95503239
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94796499
70Staphylococcus aureus infection_Homo sapiens_hsa051500.92587120
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89532250
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.87716860
73Biosynthesis of amino acids_Homo sapiens_hsa012300.86414976
74Tryptophan metabolism_Homo sapiens_hsa003800.85998620
75Ovarian steroidogenesis_Homo sapiens_hsa049130.85963406
76Bile secretion_Homo sapiens_hsa049760.84699134
77Retinol metabolism_Homo sapiens_hsa008300.84315421
78Legionellosis_Homo sapiens_hsa051340.83745326
79RNA polymerase_Homo sapiens_hsa030200.82249413
80Circadian rhythm_Homo sapiens_hsa047100.79637824
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78770342
82Base excision repair_Homo sapiens_hsa034100.78664201
83beta-Alanine metabolism_Homo sapiens_hsa004100.75802693
84Viral carcinogenesis_Homo sapiens_hsa052030.73844033
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70555973
86Mismatch repair_Homo sapiens_hsa034300.68265779
87Purine metabolism_Homo sapiens_hsa002300.68103261
88Measles_Homo sapiens_hsa051620.67341313
89B cell receptor signaling pathway_Homo sapiens_hsa046620.65080144
90Caffeine metabolism_Homo sapiens_hsa002320.64818520
91RNA degradation_Homo sapiens_hsa030180.63104428
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62527800
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61649393
94Herpes simplex infection_Homo sapiens_hsa051680.59681210
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59670825
96Glutathione metabolism_Homo sapiens_hsa004800.57787987
97Metabolic pathways_Homo sapiens_hsa011000.57577884
98Hedgehog signaling pathway_Homo sapiens_hsa043400.55268539
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.55125217
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.53376265
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.53186250
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51978523
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51772406
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51605931
105Influenza A_Homo sapiens_hsa051640.51282863
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.49883015
107Peroxisome_Homo sapiens_hsa041460.48692475
108AMPK signaling pathway_Homo sapiens_hsa041520.47421180
109Primary immunodeficiency_Homo sapiens_hsa053400.44927815
110p53 signaling pathway_Homo sapiens_hsa041150.43669859
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43659869
112Bladder cancer_Homo sapiens_hsa052190.42012745
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41443039
114Pyrimidine metabolism_Homo sapiens_hsa002400.41138359
115Inositol phosphate metabolism_Homo sapiens_hsa005620.40653427
116Nitrogen metabolism_Homo sapiens_hsa009100.37821273
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.36250152
118Vitamin digestion and absorption_Homo sapiens_hsa049770.36156863
119Small cell lung cancer_Homo sapiens_hsa052220.35846395
120Ether lipid metabolism_Homo sapiens_hsa005650.35055036
121N-Glycan biosynthesis_Homo sapiens_hsa005100.33807732
122Histidine metabolism_Homo sapiens_hsa003400.33540319
123Toxoplasmosis_Homo sapiens_hsa051450.32602179
124Hematopoietic cell lineage_Homo sapiens_hsa046400.32542368
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32292534
126Olfactory transduction_Homo sapiens_hsa047400.32273431
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31818264
128T cell receptor signaling pathway_Homo sapiens_hsa046600.31221204
129Arginine and proline metabolism_Homo sapiens_hsa003300.30317175
130Starch and sucrose metabolism_Homo sapiens_hsa005000.30087078
131Nicotine addiction_Homo sapiens_hsa050330.30059786
132Arginine biosynthesis_Homo sapiens_hsa002200.29360413
133Renin-angiotensin system_Homo sapiens_hsa046140.29312633
134Arachidonic acid metabolism_Homo sapiens_hsa005900.29035819
135Lysosome_Homo sapiens_hsa041420.28995579
136Insulin resistance_Homo sapiens_hsa049310.28888918
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28499442
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.27682446
139Sulfur metabolism_Homo sapiens_hsa009200.27569741
140Calcium signaling pathway_Homo sapiens_hsa040200.23385614
141Cocaine addiction_Homo sapiens_hsa050300.20392675
142Mineral absorption_Homo sapiens_hsa049780.17880520
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12300623
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.08346097

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