ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	9.66246878
2	negative regulation of cAMP-mediated signaling (GO:0043951)	8.52996958
3	ether lipid metabolic process (GO:0046485)	7.87091686
4	opioid receptor signaling pathway (GO:0038003)	7.72675883
5	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	7.50008042
6	behavioral response to ethanol (GO:0048149)	7.01144994
7	regulation of protein glycosylation (GO:0060049)	6.97465521
8	regulation of acrosome reaction (GO:0060046)	6.91402128
9	regulation of translational termination (GO:0006449)	6.41443858
10	thrombin receptor signaling pathway (GO:0070493)	6.29143283
11	adult feeding behavior (GO:0008343)	6.25464958
12	complement activation, alternative pathway (GO:0006957)	6.15458198
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	5.78943943
14	negative regulation of glycoprotein biosynthetic process (GO:0010561)	5.72872777
15	negative regulation of glycoprotein metabolic process (GO:1903019)	5.52176185
16	regulation of triglyceride catabolic process (GO:0010896)	5.43059481
17	sphingosine metabolic process (GO:0006670)	5.40757068
18	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.19322189
19	positive regulation of cAMP-mediated signaling (GO:0043950)	5.16429072
20	urate metabolic process (GO:0046415)	5.14421873
21	epoxygenase P450 pathway (GO:0019373)	5.09578859
22	diol metabolic process (GO:0034311)	5.09384784
23	sphingoid metabolic process (GO:0046519)	4.99996690
24	phospholipid efflux (GO:0033700)	4.92985859
25	notochord development (GO:0030903)	4.81160903
26	negative regulation of nitric oxide biosynthetic process (GO:0045019)	4.74108620
27	piRNA metabolic process (GO:0034587)	4.64805641
28	glycerol ether metabolic process (GO:0006662)	4.40938854
29	regulation of complement activation (GO:0030449)	4.27469018
30	cell-cell junction maintenance (GO:0045217)	4.20550804
31	regulation of protein activation cascade (GO:2000257)	4.11981930
32	maintenance of gastrointestinal epithelium (GO:0030277)	4.10718336
33	ether metabolic process (GO:0018904)	4.02078594
34	neurotransmitter catabolic process (GO:0042135)	3.95282665
35	cellular response to ammonium ion (GO:0071242)	3.92374396
36	ncRNA catabolic process (GO:0034661)	3.81228584
37	regulation of cholesterol esterification (GO:0010872)	3.77522340
38	cell junction maintenance (GO:0034331)	3.76780988
39	sperm capacitation (GO:0048240)	3.76438002
40	mRNA cleavage (GO:0006379)	3.76149948
41	flavonoid metabolic process (GO:0009812)	3.74703123
42	regulation of guanylate cyclase activity (GO:0031282)	3.74005051
43	negative regulation of keratinocyte proliferation (GO:0010839)	3.71268480
44	intestinal absorption (GO:0050892)	3.71242742
45	glycosphingolipid metabolic process (GO:0006687)	3.70503066
46	high-density lipoprotein particle remodeling (GO:0034375)	3.69200673
47	positive regulation of icosanoid secretion (GO:0032305)	3.68709107
48	cellular glucuronidation (GO:0052695)	3.62580548
49	drug metabolic process (GO:0017144)	3.52461860
50	auditory receptor cell differentiation (GO:0042491)	3.46627111
51	positive regulation of fatty acid transport (GO:2000193)	3.46338423
52	neurotransmitter biosynthetic process (GO:0042136)	3.43365126
53	glucuronate metabolic process (GO:0019585)	3.43252409
54	uronic acid metabolic process (GO:0006063)	3.43252409
55	signal complex assembly (GO:0007172)	3.43236504
56	regulation of lipoprotein metabolic process (GO:0050746)	3.42482023
57	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.41905367
58	fat-soluble vitamin biosynthetic process (GO:0042362)	3.39124123
59	negative regulation of inclusion body assembly (GO:0090084)	3.39047102
60	omega-hydroxylase P450 pathway (GO:0097267)	3.36904966
61	response to phenylpropanoid (GO:0080184)	3.30138654
62	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.28462851
63	regulation of glutamate receptor signaling pathway (GO:1900449)	3.25198253
64	renal system process involved in regulation of blood volume (GO:0001977)	3.23050282
65	positive regulation of megakaryocyte differentiation (GO:0045654)	3.20150154
66	angiotensin maturation (GO:0002003)	3.16528738
67	GDP-mannose metabolic process (GO:0019673)	3.14114168
68	positive regulation of triglyceride metabolic process (GO:0090208)	3.11998015
69	DNA replication-dependent nucleosome organization (GO:0034723)	3.11110012
70	DNA replication-dependent nucleosome assembly (GO:0006335)	3.11110012
71	positive regulation of triglyceride lipase activity (GO:0061365)	3.07846252
72	positive regulation of lipoprotein lipase activity (GO:0051006)	3.07846252
73	reverse cholesterol transport (GO:0043691)	3.07842836
74	regulation of cAMP-mediated signaling (GO:0043949)	3.04700993
75	vitamin catabolic process (GO:0009111)	3.03118356
76	fat-soluble vitamin catabolic process (GO:0042363)	3.03118356
77	negative regulation of protein activation cascade (GO:2000258)	2.99922991
78	glomerular visceral epithelial cell development (GO:0072015)	2.98856935
79	regulation of glycoprotein biosynthetic process (GO:0010559)	2.98408976
80	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.97025708
81	negative regulation of cell-matrix adhesion (GO:0001953)	2.96605898
82	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.95771056
83	regulation of keratinocyte proliferation (GO:0010837)	2.91840596
84	negative regulation of epidermal cell differentiation (GO:0045605)	2.91438301
85	drug catabolic process (GO:0042737)	2.91261093
86	positive regulation of guanylate cyclase activity (GO:0031284)	2.90500839
87	exogenous drug catabolic process (GO:0042738)	2.89293278
88	epithelial cell-cell adhesion (GO:0090136)	2.89287128
89	interleukin-1-mediated signaling pathway (GO:0070498)	2.87376574
90	amyloid precursor protein metabolic process (GO:0042982)	2.87267667
91	regulation of glycoprotein metabolic process (GO:1903018)	2.86278060
92	regulation of respiratory burst (GO:0060263)	2.86078991
93	thyroid hormone generation (GO:0006590)	2.84820744
94	response to methylmercury (GO:0051597)	2.84450210
95	positive regulation of lipid catabolic process (GO:0050996)	2.78442023
96	histone H3 deacetylation (GO:0070932)	2.77962247
97	quinone biosynthetic process (GO:1901663)	2.77834358
98	negative regulation of complement activation (GO:0045916)	2.77591776
99	regulation of icosanoid secretion (GO:0032303)	2.74723939
100	epithelial structure maintenance (GO:0010669)	2.74071941

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	4.28041874
2	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.01883832
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.87212228
4	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.81766197
5	VDR_22108803_ChIP-Seq_LS180_Human	2.46307377
6	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.40267941
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.28320410
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26460519
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.26460519
10	RXR_22108803_ChIP-Seq_LS180_Human	2.20537170
11	GATA4_25053715_ChIP-Seq_YYC3_Human	2.14064931
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.07818788
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.02349537
14	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.98044551
15	EGR1_19032775_ChIP-ChIP_M12_Human	1.96483344
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.94296728
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92625853
18	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.87290228
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84328520
20	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.81218393
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79916307
22	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78221759
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.76397077
24	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.76384219
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74001929
26	GATA6_25053715_ChIP-Seq_YYC3_Human	1.72434662
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71386532
28	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.61759885
29	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.61647916
30	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.58621227
31	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.57710799
32	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.55004262
33	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.54583437
34	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.53959730
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52830020
36	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.52475905
37	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.51894707
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50835077
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50835077
40	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.46616198
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.45349843
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44264087
43	CEBPB_22108803_ChIP-Seq_LS180_Human	1.43232486
44	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.40375574
45	E2F1_20622854_ChIP-Seq_HELA_Human	1.39573083
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36479870
47	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.36347165
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.35920612
49	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35339035
50	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.33982769
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.33769223
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.29066308
53	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28912761
54	GATA1_22025678_ChIP-Seq_K562_Human	1.22866367
55	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22192185
56	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.21835312
57	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.21140847
58	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.20322518
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18902560
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18339293
61	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.15914063
62	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15680554
63	RAC3_21632823_ChIP-Seq_H3396_Human	1.14263163
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12918016
65	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.12492070
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12233862
67	SOX2_20726797_ChIP-Seq_SW620_Human	1.11704020
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.11079995
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11079995
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09366939
71	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.08925649
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08902657
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08601449
74	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.08258886
75	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.06167130
76	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.05983539
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05609127
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04740852
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04728566
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04597477
81	CTCF_20526341_ChIP-Seq_ESCs_Human	1.03780123
82	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03249844
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01945115
84	ERA_21632823_ChIP-Seq_H3396_Human	1.00872746
85	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99188584
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98694861
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.97260656
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96660663
89	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96215308
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95619815
91	TP53_18474530_ChIP-ChIP_U2OS_Human	0.94034016
92	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.93914028
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93458290
94	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.92752333
95	BCOR_27268052_Chip-Seq_Bcells_Human	0.92691031
96	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.92443565
97	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.92292109
98	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.91812513
99	PHF8_20622854_ChIP-Seq_HELA_Human	0.91292731
100	CTCF_27219007_Chip-Seq_Bcells_Human	0.89507529

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.91733794
2	MP0002876_abnormal_thyroid_physiology	5.36669509
3	MP0009278_abnormal_bone_marrow	4.02587531
4	MP0009780_abnormal_chondrocyte_physiolo	3.96437199
5	MP0010234_abnormal_vibrissa_follicle	3.66904568
6	MP0009840_abnormal_foam_cell	3.61499745
7	MP0008872_abnormal_physiological_respon	3.40723709
8	MP0000678_abnormal_parathyroid_gland	3.38898788
9	MP0003183_abnormal_peptide_metabolism	2.90720457
10	MP0001664_abnormal_digestion	2.87027079
11	MP0001968_abnormal_touch/_nociception	2.81840159
12	MP0002796_impaired_skin_barrier	2.48206886
13	MP0004264_abnormal_extraembryonic_tissu	2.45642187
14	MP0005503_abnormal_tendon_morphology	2.44379259
15	MP0001501_abnormal_sleep_pattern	2.34909045
16	MP0003879_abnormal_hair_cell	2.21765786
17	MP0003941_abnormal_skin_development	2.08593260
18	MP0004147_increased_porphyrin_level	2.05065638
19	MP0005085_abnormal_gallbladder_physiolo	1.89524724
20	MP0009333_abnormal_splenocyte_physiolog	1.88001604
21	MP0009764_decreased_sensitivity_to	1.85170455
22	MP0002249_abnormal_larynx_morphology	1.82614235
23	MP0005365_abnormal_bile_salt	1.74902993
24	MP0005646_abnormal_pituitary_gland	1.72093981
25	MP0009384_cardiac_valve_regurgitation	1.72008509
26	MP0003638_abnormal_response/metabolism_	1.69335301
27	MP0002098_abnormal_vibrissa_morphology	1.66400531
28	MP0000681_abnormal_thyroid_gland	1.63897448
29	MP0002139_abnormal_hepatobiliary_system	1.59626650
30	MP0005167_abnormal_blood-brain_barrier	1.52748653
31	MP0004782_abnormal_surfactant_physiolog	1.49788088
32	MP0005501_abnormal_skin_physiology	1.49433737
33	MP0001485_abnormal_pinna_reflex	1.47986005
34	MP0005670_abnormal_white_adipose	1.47684410
35	MP0003567_abnormal_fetal_cardiomyocyte	1.43621323
36	MP0010329_abnormal_lipoprotein_level	1.43329010
37	MP0004019_abnormal_vitamin_homeostasis	1.42599329
38	MP0001666_abnormal_nutrient_absorption	1.41153748
39	MP0009643_abnormal_urine_homeostasis	1.38820379
40	MP0001529_abnormal_vocalization	1.33881400
41	MP0005551_abnormal_eye_electrophysiolog	1.27762325
42	MP0001764_abnormal_homeostasis	1.25889007
43	MP0010155_abnormal_intestine_physiology	1.24235437
44	MP0008875_abnormal_xenobiotic_pharmacok	1.22355886
45	MP0003880_abnormal_central_pattern	1.16350316
46	MP0005332_abnormal_amino_acid	1.14582026
47	MP0000230_abnormal_systemic_arterial	1.13925493
48	MP0001545_abnormal_hematopoietic_system	1.11159066
49	MP0005397_hematopoietic_system_phenotyp	1.11159066
50	MP0000538_abnormal_urinary_bladder	1.08323744
51	MP0008789_abnormal_olfactory_epithelium	1.06813356
52	MP0003191_abnormal_cellular_cholesterol	1.05157191
53	MP0003045_fibrosis	1.03492444
54	MP0004858_abnormal_nervous_system	1.00470094
55	MP0003866_abnormal_defecation	0.99971281
56	MP0006035_abnormal_mitochondrial_morpho	0.99607189
57	MP0004043_abnormal_pH_regulation	0.99277749
58	MP0003718_maternal_effect	0.96538994
59	MP0002733_abnormal_thermal_nociception	0.96201709
60	MP0010771_integument_phenotype	0.91088151
61	MP0009765_abnormal_xenobiotic_induced	0.90923089
62	MP0002971_abnormal_brown_adipose	0.88241839
63	MP0001849_ear_inflammation	0.86060632
64	MP0001881_abnormal_mammary_gland	0.82956220
65	MP0003868_abnormal_feces_composition	0.82481782
66	MP0000490_abnormal_crypts_of	0.80414171
67	MP0003633_abnormal_nervous_system	0.77568240
68	MP0002136_abnormal_kidney_physiology	0.77095169
69	MP0001756_abnormal_urination	0.76348868
70	MP0005367_renal/urinary_system_phenotyp	0.76298641
71	MP0000516_abnormal_urinary_system	0.76298641
72	MP0000049_abnormal_middle_ear	0.74620364
73	MP0001919_abnormal_reproductive_system	0.73386270
74	MP0001765_abnormal_ion_homeostasis	0.73197084
75	MP0002118_abnormal_lipid_homeostasis	0.71652167
76	MP0005395_other_phenotype	0.71174918
77	MP0005636_abnormal_mineral_homeostasis	0.69842358
78	MP0002822_catalepsy	0.69225757
79	MP0000749_muscle_degeneration	0.67434866
80	MP0003195_calcinosis	0.64360195
81	MP0005310_abnormal_salivary_gland	0.63127186
82	MP0002282_abnormal_trachea_morphology	0.62190336
83	MP0001963_abnormal_hearing_physiology	0.61065872
84	MP0004085_abnormal_heartbeat	0.59348083
85	MP0003959_abnormal_lean_body	0.59224377
86	MP0003806_abnormal_nucleotide_metabolis	0.59067986
87	MP0005645_abnormal_hypothalamus_physiol	0.59044926
88	MP0002254_reproductive_system_inflammat	0.58606826
89	MP0001986_abnormal_taste_sensitivity	0.58176652
90	MP0001502_abnormal_circadian_rhythm	0.55124792
91	MP0004742_abnormal_vestibular_system	0.54993101
92	MP0001270_distended_abdomen	0.54972722
93	MP0002069_abnormal_eating/drinking_beha	0.54302905
94	MP0009672_abnormal_birth_weight	0.53898713
95	MP0006276_abnormal_autonomic_nervous	0.52454626
96	MP0000566_synostosis	0.51522265
97	MP0005319_abnormal_enzyme/_coenzyme	0.51086520
98	MP0000467_abnormal_esophagus_morphology	0.50038002
99	MP0005499_abnormal_olfactory_system	0.48648906
100	MP0005394_taste/olfaction_phenotype	0.48648906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.44812100
2	Pancreatic islet-cell hyperplasia (HP:0004510)	5.38493229
3	Intestinal atresia (HP:0011100)	5.34891655
4	Hydroxyprolinuria (HP:0003080)	4.99392791
5	Abnormality of proline metabolism (HP:0010907)	4.99392791
6	Thickened helices (HP:0000391)	4.85316052
7	Abnormality of the aortic arch (HP:0012303)	4.81933155
8	Volvulus (HP:0002580)	4.79775823
9	Oligodontia (HP:0000677)	4.71386274
10	Broad alveolar ridges (HP:0000187)	4.68519554
11	Large for gestational age (HP:0001520)	4.15109994
12	Ileus (HP:0002595)	4.04866771
13	Congenital ichthyosiform erythroderma (HP:0007431)	4.01720733
14	Mesangial abnormality (HP:0001966)	3.70181063
15	Pili torti (HP:0003777)	3.51936911
16	Abnormal hair laboratory examination (HP:0003328)	3.44096338
17	Xanthomatosis (HP:0000991)	3.38832141
18	Abnormality of the pancreatic islet cells (HP:0006476)	3.36966244
19	Abnormality of endocrine pancreas physiology (HP:0012093)	3.36966244
20	Tubular atrophy (HP:0000092)	3.14319511
21	Decreased circulating renin level (HP:0003351)	3.14155181
22	Agitation (HP:0000713)	2.99477290
23	Focal motor seizures (HP:0011153)	2.97305397
24	Hyperactive renin-angiotensin system (HP:0000841)	2.86950718
25	Poor head control (HP:0002421)	2.86133088
26	Gastrointestinal atresia (HP:0002589)	2.83890384
27	Gaze-evoked nystagmus (HP:0000640)	2.79316317
28	Malnutrition (HP:0004395)	2.74817740
29	Neonatal respiratory distress (HP:0002643)	2.68173120
30	Spontaneous abortion (HP:0005268)	2.60105693
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.55553770
32	Abnormality of glycine metabolism (HP:0010895)	2.55553770
33	Abnormality of renin-angiotensin system (HP:0000847)	2.53197461
34	Abdominal distention (HP:0003270)	2.51370221
35	Hypoplastic iliac wings (HP:0002866)	2.44796062
36	Hypoproteinemia (HP:0003075)	2.40429956
37	Poikiloderma (HP:0001029)	2.40083906
38	Abnormality of nail color (HP:0100643)	2.40058468
39	Lissencephaly (HP:0001339)	2.38938300
40	Hyperglycinuria (HP:0003108)	2.38484572
41	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.38097114
42	Abnormality of polysaccharide metabolism (HP:0011012)	2.38097114
43	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.38097114
44	High anterior hairline (HP:0009890)	2.37630811
45	Hyperpituitarism (HP:0010514)	2.36588931
46	Azoospermia (HP:0000027)	2.35087636
47	Amelogenesis imperfecta (HP:0000705)	2.33402553
48	Urinary glycosaminoglycan excretion (HP:0003541)	2.33361154
49	Mucopolysacchariduria (HP:0008155)	2.33361154
50	Abnormality of the ileum (HP:0001549)	2.28609069
51	Abnormality of pyrimidine metabolism (HP:0004353)	2.25593878
52	Large eyes (HP:0001090)	2.24301376
53	Optic nerve hypoplasia (HP:0000609)	2.23226701
54	Conjugated hyperbilirubinemia (HP:0002908)	2.23168672
55	Focal segmental glomerulosclerosis (HP:0000097)	2.20625948
56	Alkalosis (HP:0001948)	2.19685847
57	Hemorrhage of the eye (HP:0011885)	2.19284872
58	Hypercortisolism (HP:0001578)	2.18857384
59	Metabolic alkalosis (HP:0200114)	2.18844933
60	Tented upper lip vermilion (HP:0010804)	2.16767537
61	Impulsivity (HP:0100710)	2.14376785
62	Abnormality of the alveolar ridges (HP:0006477)	2.12262953
63	Dysostosis multiplex (HP:0000943)	2.08977347
64	Abnormality of nucleobase metabolism (HP:0010932)	2.08657439
65	Myositis (HP:0100614)	2.02169202
66	Adrenal overactivity (HP:0002717)	2.01240858
67	Cerebellar dysplasia (HP:0007033)	2.00980363
68	Abnormality of purine metabolism (HP:0004352)	2.00894904
69	Thyroid-stimulating hormone excess (HP:0002925)	10.6381981
70	Choroideremia (HP:0001139)	1.98168646
71	Vascular calcification (HP:0004934)	1.97973653
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96450538
73	Ectropion (HP:0000656)	1.95938465
74	Progressive inability to walk (HP:0002505)	1.94937912
75	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.94563218
76	Widely patent fontanelles and sutures (HP:0004492)	1.93579001
77	Syncope (HP:0001279)	1.89830042
78	J-shaped sella turcica (HP:0002680)	1.89159406
79	Orchitis (HP:0100796)	1.86526637
80	Flared iliac wings (HP:0002869)	1.85969643
81	Goiter (HP:0000853)	1.85713998
82	Congenital sensorineural hearing impairment (HP:0008527)	1.85597639
83	Nonprogressive disorder (HP:0003680)	1.84559998
84	Nephroblastoma (Wilms tumor) (HP:0002667)	1.84104076
85	Hypophosphatemic rickets (HP:0004912)	1.83920677
86	Hyperaldosteronism (HP:0000859)	1.83624332
87	Gastrointestinal dysmotility (HP:0002579)	1.83395598
88	Poor speech (HP:0002465)	1.82887858
89	Pigmentary retinal degeneration (HP:0001146)	1.78736888
90	Abnormality of the vitreous humor (HP:0004327)	1.77335048
91	Glomerulosclerosis (HP:0000096)	1.74037903
92	Hamartoma (HP:0010566)	1.73812637
93	Gout (HP:0001997)	1.73633290
94	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.73324048
95	Embryonal renal neoplasm (HP:0011794)	1.73136913
96	Neoplasm of the lung (HP:0100526)	1.71933958
97	Potter facies (HP:0002009)	1.71433740
98	Facial shape deformation (HP:0011334)	1.71433740
99	Breast hypoplasia (HP:0003187)	1.68143011
100	Short palpebral fissure (HP:0012745)	1.68059247

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	7.88380062
2	MST1R	4.66890980
3	ERN1	4.48042948
4	IRAK1	4.16552316
5	FRK	3.82954576
6	ACVR1B	3.57218021
7	CASK	3.00709198
8	EPHA2	2.67177487
9	TSSK6	2.40938259
10	PNCK	2.32794936
11	ADRBK1	2.25575798
12	RIPK1	2.19963317
13	IRAK3	2.18762309
14	MET	2.00357109
15	STK38L	1.84477270
16	PINK1	1.82863524
17	DYRK3	1.64957374
18	EPHA4	1.55218094
19	GRK1	1.54545625
20	STK39	1.52597514
21	NTRK3	1.48365330
22	PRKCG	1.33708572
23	TGFBR1	1.30333853
24	WEE1	1.24973823
25	TYRO3	1.21860361
26	OXSR1	1.19626144
27	PRKCE	1.19279090
28	MELK	1.18933738
29	CLK1	1.17453711
30	TIE1	1.16625119
31	MST4	1.11454863
32	PRKCI	1.03330793
33	MAPK15	1.02577536
34	SIK1	1.01526894
35	ERBB2	0.95386385
36	MAP2K2	0.90679508
37	DAPK2	0.89296026
38	EPHB2	0.86870497
39	MAP4K2	0.85985170
40	STK24	0.78785641
41	NUAK1	0.71907491
42	PRKG2	0.70069146
43	MAPKAPK5	0.69782838
44	MAP2K6	0.66426573
45	MAPKAPK3	0.65198898
46	LMTK2	0.63884358
47	NME1	0.61642206
48	PIK3CA	0.59225129
49	STK38	0.58780217
50	DYRK1A	0.56577665
51	PTK2B	0.55919152
52	MAPK11	0.53565039
53	BMPR1B	0.51501678
54	TLK1	0.49810109
55	MKNK2	0.49074869
56	ILK	0.46576138
57	PTK6	0.45327804
58	PKN2	0.44107987
59	STK3	0.43747977
60	FLT3	0.42133100
61	CAMK2A	0.39514279
62	PRKCA	0.34283427
63	PRKCB	0.31789300
64	CSNK1E	0.31776878
65	ZAP70	0.31103145
66	PDPK1	0.28238898
67	LATS2	0.27939830
68	MAPK13	0.27679558
69	PRKACG	0.26141449
70	DYRK1B	0.25452771
71	ICK	0.25259743
72	SIK3	0.24831319
73	STK10	0.23726597
74	ROCK1	0.23274622
75	NME2	0.21136732
76	CAMK4	0.20999067
77	PRKCZ	0.20934587
78	FER	0.20370146
79	PDK1	0.18897105
80	CDC42BPA	0.18445067
81	GRK5	0.18336922
82	PRKACA	0.18147951
83	MAPK1	0.17294736
84	MAPK3	0.16895925
85	MAPK8	0.16873837
86	MKNK1	0.15432984
87	MAP2K1	0.15081602
88	MATK	0.13833379
89	MAP3K8	0.13716302
90	PIK3CG	0.13635504
91	BRAF	0.12371235
92	CSF1R	0.12180986
93	YES1	0.11257314
94	PRKCQ	0.11091799
95	BMX	0.11073075
96	NEK2	0.11017964
97	WNK4	0.10891947
98	RPS6KA6	0.10342117
99	CAMK1	0.10040698
100	DAPK1	0.09850118

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.26014182
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.10694800
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.98825911
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.92021229
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.83798583
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.50803467
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36266700
8	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.35228686
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.30965258
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.09329620
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.04938393
12	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.04035447
13	Retinol metabolism_Homo sapiens_hsa00830	2.02819457
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.01175710
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.97363785
16	Histidine metabolism_Homo sapiens_hsa00340	1.96141600
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94328863
18	Sphingolipid metabolism_Homo sapiens_hsa00600	1.92603195
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.91404684
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.86389309
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85792449
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.85304005
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.79369671
24	Glycerolipid metabolism_Homo sapiens_hsa00561	1.77896870
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.73826457
26	Prion diseases_Homo sapiens_hsa05020	1.72477147
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.72032224
28	Mineral absorption_Homo sapiens_hsa04978	1.71660904
29	Fatty acid degradation_Homo sapiens_hsa00071	1.62372409
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.57787141
31	Caffeine metabolism_Homo sapiens_hsa00232	1.57425047
32	Renin-angiotensin system_Homo sapiens_hsa04614	1.56838098
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55740420
34	ABC transporters_Homo sapiens_hsa02010	1.46926252
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.44283892
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.41780321
37	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.28605199
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.18590872
39	Sulfur relay system_Homo sapiens_hsa04122	1.18222228
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.16995403
41	Olfactory transduction_Homo sapiens_hsa04740	1.14308344
42	Bile secretion_Homo sapiens_hsa04976	1.12762985
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11482708
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.09649989
45	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.08732110
46	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.06442429
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.02755963
48	Other glycan degradation_Homo sapiens_hsa00511	1.02688487
49	Butanoate metabolism_Homo sapiens_hsa00650	1.01661044
50	PPAR signaling pathway_Homo sapiens_hsa03320	0.95106358
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94263920
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.91014167
53	Protein digestion and absorption_Homo sapiens_hsa04974	0.89548109
54	Glutathione metabolism_Homo sapiens_hsa00480	0.85804631
55	Sulfur metabolism_Homo sapiens_hsa00920	0.84910859
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.80928094
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80047637
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.78556093
59	Galactose metabolism_Homo sapiens_hsa00052	0.76909694
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69813274
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69500103
62	Pancreatic secretion_Homo sapiens_hsa04972	0.66625003
63	Notch signaling pathway_Homo sapiens_hsa04330	0.63114058
64	Phototransduction_Homo sapiens_hsa04744	0.62112598
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61659751
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61583159
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61246052
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.59404369
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59263542
70	Taste transduction_Homo sapiens_hsa04742	0.56026654
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51091678
72	Peroxisome_Homo sapiens_hsa04146	0.47735755
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.46938596
74	Morphine addiction_Homo sapiens_hsa05032	0.46832795
75	Metabolic pathways_Homo sapiens_hsa01100	0.43243629
76	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.42925986
77	Lysosome_Homo sapiens_hsa04142	0.31199994
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31102889
79	Salivary secretion_Homo sapiens_hsa04970	0.28070211
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.26979095
81	Circadian entrainment_Homo sapiens_hsa04713	0.26805123
82	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.25437250
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.24741823
84	Serotonergic synapse_Homo sapiens_hsa04726	0.23189538
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22541701
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.19395179
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.18313241
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.15808739
89	Tight junction_Homo sapiens_hsa04530	0.13649188
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.11589456
91	Axon guidance_Homo sapiens_hsa04360	0.09599139
92	Legionellosis_Homo sapiens_hsa05134	0.08987285
93	Renin secretion_Homo sapiens_hsa04924	0.08426817
94	Insulin secretion_Homo sapiens_hsa04911	0.07891290
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.07725894
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.06360383
97	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.03977616
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.03093845
99	Amoebiasis_Homo sapiens_hsa05146	0.02044771
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.01862711

MROH3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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