MROH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.85775729
2cell-cell recognition (GO:0009988)9.59923122
3binding of sperm to zona pellucida (GO:0007339)9.59745631
4motile cilium assembly (GO:0044458)9.38386024
5regulation of cilium movement (GO:0003352)9.34257538
6spermatid development (GO:0007286)9.23216682
7reproduction (GO:0000003)9.03980582
8cilium movement (GO:0003341)8.44365335
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.07349917
10response to pheromone (GO:0019236)8.05917018
11piRNA metabolic process (GO:0034587)7.54388996
12microtubule depolymerization (GO:0007019)7.47577301
13single fertilization (GO:0007338)7.24981071
14sperm capacitation (GO:0048240)7.15316442
15synaptonemal complex organization (GO:0070193)7.07061839
16male meiosis (GO:0007140)7.02074483
17negative regulation of inclusion body assembly (GO:0090084)6.87599892
18synaptonemal complex assembly (GO:0007130)6.63913056
19spermatogenesis (GO:0007283)6.39716752
20male gamete generation (GO:0048232)6.36988690
21protein targeting to Golgi (GO:0000042)6.31201890
22fertilization (GO:0009566)6.24511490
23establishment of protein localization to Golgi (GO:0072600)6.15390527
24rRNA methylation (GO:0031167)6.09601313
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.05687359
26organic cation transport (GO:0015695)5.94746672
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.89806182
28gamete generation (GO:0007276)5.87703163
29regulation of inclusion body assembly (GO:0090083)5.76525480
30ventricular system development (GO:0021591)5.76188400
31male meiosis I (GO:0007141)5.57512693
32calcium ion-dependent exocytosis (GO:0017156)5.54621257
33phosphatidylethanolamine metabolic process (GO:0046337)5.53378438
34regulation of microtubule-based movement (GO:0060632)5.49742322
35cellular ketone body metabolic process (GO:0046950)5.48759508
36regulation of Rab GTPase activity (GO:0032313)5.34273445
37positive regulation of Rab GTPase activity (GO:0032851)5.34273445
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.23624034
39germ cell development (GO:0007281)5.19219176
40centriole replication (GO:0007099)5.03468623
41rRNA modification (GO:0000154)5.00988740
42left/right pattern formation (GO:0060972)4.85283962
43ketone body metabolic process (GO:1902224)4.81119969
44DNA methylation involved in gamete generation (GO:0043046)4.78357050
45cell recognition (GO:0008037)4.75498619
46microtubule severing (GO:0051013)4.75315133
47multicellular organismal reproductive process (GO:0048609)4.67729565
48regulation of transcription involved in cell fate commitment (GO:0060850)4.64844120
49chromatin silencing (GO:0006342)4.64282808
50protein localization to Golgi apparatus (GO:0034067)4.63918851
51meiosis I (GO:0007127)4.54101397
52chromosome organization involved in meiosis (GO:0070192)4.44276067
53meiotic nuclear division (GO:0007126)4.40097321
54glycerol ether metabolic process (GO:0006662)4.30028781
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28789473
56spermatid nucleus differentiation (GO:0007289)4.27648762
57chromosome condensation (GO:0030261)4.14052687
58seminiferous tubule development (GO:0072520)4.02668409
59protein polyglutamylation (GO:0018095)3.97832468
60ether metabolic process (GO:0018904)3.96600637
61DNA packaging (GO:0006323)3.96444156
62microtubule polymerization or depolymerization (GO:0031109)3.95460435
63negative regulation of Rho protein signal transduction (GO:0035024)3.91233728
64regulation of centriole replication (GO:0046599)3.80538644
65genitalia morphogenesis (GO:0035112)3.73103843
66multicellular organismal development (GO:0007275)3.69769893
67regulation of spindle checkpoint (GO:0090231)3.64439470
68histone H3-K9 demethylation (GO:0033169)3.63805682
69multicellular organismal movement (GO:0050879)3.60401410
70musculoskeletal movement (GO:0050881)3.60401410
71coenzyme catabolic process (GO:0009109)3.56936848
72monoubiquitinated protein deubiquitination (GO:0035520)3.55300462
73single strand break repair (GO:0000012)3.46830387
74peptidyl-threonine dephosphorylation (GO:0035970)3.46178605
75meiotic cell cycle (GO:0051321)3.46049221
76response to acidic pH (GO:0010447)3.28798950
77protein localization to cilium (GO:0061512)3.28459558
78axoneme assembly (GO:0035082)3.27813120
79nucleus organization (GO:0006997)3.26317300
80mitotic sister chromatid cohesion (GO:0007064)3.24553265
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.21745935
82negative regulation of gene expression, epigenetic (GO:0045814)3.21703104
83regulation of meiosis I (GO:0060631)3.18750050
84polyamine biosynthetic process (GO:0006596)3.16145958
85microtubule-based movement (GO:0007018)3.15371836
86nucleosome disassembly (GO:0006337)3.14385078
87protein-DNA complex disassembly (GO:0032986)3.14385078
88protein refolding (GO:0042026)3.14373778
89regulation of T-helper 2 cell differentiation (GO:0045628)3.14152083
90cellular response to pH (GO:0071467)3.13540445
91chaperone-mediated protein complex assembly (GO:0051131)3.11542096
92regulation of somitogenesis (GO:0014807)3.10576186
93amino-acid betaine transport (GO:0015838)3.09682658
94carnitine transport (GO:0015879)3.09682658
95RNA localization (GO:0006403)3.05774647
96meiotic cell cycle process (GO:1903046)3.05254427
97positive regulation of guanylate cyclase activity (GO:0031284)3.04724069
98NAD biosynthetic process (GO:0009435)3.01575583
99glomerular visceral epithelial cell development (GO:0072015)3.00996779
100cerebral cortex neuron differentiation (GO:0021895)3.00308551
101negative regulation of organelle assembly (GO:1902116)3.00094422
102RNA destabilization (GO:0050779)2.98953193
103sexual reproduction (GO:0019953)2.98417675
104regulation of interleukin-13 production (GO:0032656)2.97165038
105carnitine transmembrane transport (GO:1902603)2.95495583
106homeostasis of number of cells within a tissue (GO:0048873)2.95210264
107glycolytic process (GO:0006096)2.94179320
108cilium organization (GO:0044782)2.93189574
109Golgi to endosome transport (GO:0006895)2.91475389
110polyol catabolic process (GO:0046174)2.89539446
111regulation of guanylate cyclase activity (GO:0031282)2.89289958
112interferon-gamma secretion (GO:0072643)2.87886758
113glomerular epithelial cell development (GO:0072310)2.87463239
114microtubule nucleation (GO:0007020)2.84936364
115regulation of phosphoprotein phosphatase activity (GO:0043666)2.82812787
116cilium assembly (GO:0042384)2.80459956
117outflow tract septum morphogenesis (GO:0003148)2.79395088
118nuclear pore complex assembly (GO:0051292)2.78477151
119cilium morphogenesis (GO:0060271)2.78468246
120regulation of ARF GTPase activity (GO:0032312)2.77700266
121membrane protein intracellular domain proteolysis (GO:0031293)2.74843694
122negative regulation of histone methylation (GO:0031061)2.74481108
123regulation of histone H3-K27 methylation (GO:0061085)2.74018750
124DNA conformation change (GO:0071103)2.73748232
125protein K11-linked deubiquitination (GO:0035871)2.72615511
126coronary vasculature morphogenesis (GO:0060977)2.70733696
127cellular component assembly involved in morphogenesis (GO:0010927)2.69695340
128gene silencing by RNA (GO:0031047)2.67981724
129nucleoside diphosphate phosphorylation (GO:0006165)2.66798124
130regulation of protein kinase C signaling (GO:0090036)2.63094147
131intraciliary transport (GO:0042073)2.61391618
132peptidyl-glutamic acid modification (GO:0018200)2.59308889
133calcium ion import (GO:0070509)2.56375766
134alditol metabolic process (GO:0019400)2.55548767
135regulation of cilium assembly (GO:1902017)2.54850739
136regulation of protein kinase A signaling (GO:0010738)2.54216508
137centriole assembly (GO:0098534)2.53991950
138protein depolymerization (GO:0051261)2.53767706
139regulation of response to osmotic stress (GO:0047484)2.52153347
140mitochondrion degradation (GO:0000422)2.50424513
141sperm motility (GO:0030317)13.4927077
142fusion of sperm to egg plasma membrane (GO:0007342)12.9595498
143acrosome reaction (GO:0007340)11.7876116
144multicellular organism reproduction (GO:0032504)10.7699855
145sperm-egg recognition (GO:0035036)10.7422813
146cilium or flagellum-dependent cell motility (GO:0001539)10.5636437
147axonemal dynein complex assembly (GO:0070286)10.2683026
148acrosome assembly (GO:0001675)10.2102214
149cell wall macromolecule catabolic process (GO:0016998)10.1499846
150cell wall macromolecule metabolic process (GO:0044036)10.1499846
151epithelial cilium movement (GO:0003351)10.1270026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.34505565
2EZH2_22144423_ChIP-Seq_EOC_Human5.58297992
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.65652617
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.78013702
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66327293
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.21612130
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98587716
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94509932
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.71000151
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66819604
11VDR_22108803_ChIP-Seq_LS180_Human2.34707825
12DROSHA_22980978_ChIP-Seq_HELA_Human2.29774259
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05974032
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.04067133
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.03573332
16ELF1_20517297_ChIP-Seq_JURKAT_Human2.00111233
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98676351
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95681423
19ZNF274_21170338_ChIP-Seq_K562_Hela1.93831374
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.87673839
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.86715887
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82266325
23SMC4_20622854_ChIP-Seq_HELA_Human1.82095134
24ERA_21632823_ChIP-Seq_H3396_Human1.76518482
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76190133
26RAC3_21632823_ChIP-Seq_H3396_Human1.74840062
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74767099
28BCL6_27268052_Chip-Seq_Bcells_Human1.73209791
29LXR_22292898_ChIP-Seq_THP-1_Human1.70925217
30P68_20966046_ChIP-Seq_HELA_Human1.69504006
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.68185426
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67909578
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67336215
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66628831
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65981883
36NANOG_20526341_ChIP-Seq_ESCs_Human1.65528736
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64180323
38BCOR_27268052_Chip-Seq_Bcells_Human1.59492188
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.58791197
40REST_21632747_ChIP-Seq_MESCs_Mouse1.57266183
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.56779392
42OCT4_20526341_ChIP-Seq_ESCs_Human1.55949069
43E2F1_20622854_ChIP-Seq_HELA_Human1.55923995
44TP63_22573176_ChIP-Seq_HFKS_Human1.54171389
45STAT1_17558387_ChIP-Seq_HELA_Human1.54078913
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53599705
47PHF8_20622854_ChIP-Seq_HELA_Human1.51980879
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50229214
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49968560
50TAF2_19829295_ChIP-Seq_ESCs_Human1.47066425
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.45126510
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45069595
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44957868
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44729692
55CBP_20019798_ChIP-Seq_JUKART_Human1.44729692
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.43298671
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.42793802
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40526651
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40122943
60ER_23166858_ChIP-Seq_MCF-7_Human1.37251361
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36388607
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35992098
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.35947929
64KDM2B_26808549_Chip-Seq_REH_Human1.35614777
65GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35311415
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35202526
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35191207
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34445670
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34216350
70P300_27268052_Chip-Seq_Bcells_Human1.33814837
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.33346919
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32564712
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32198687
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31508505
75SA1_27219007_Chip-Seq_Bcells_Human1.30544322
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30149500
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27140986
78FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26427483
79RBPJ_21746931_ChIP-Seq_IB4_Human1.26157942
80P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26018246
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25347313
82TAF15_26573619_Chip-Seq_HEK293_Human1.24962939
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24482675
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.24463496
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22815399
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.21584328
87GF1_26923725_Chip-Seq_HPCs_Mouse1.21540551
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.21479740
89CEBPB_22108803_ChIP-Seq_LS180_Human1.21149290
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20299423
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20299423
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20286753
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18352200
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.18349268
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17352858
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16544967
97AR_21572438_ChIP-Seq_LNCaP_Human1.15501309
98GATA3_21867929_ChIP-Seq_CD8_Mouse1.14934394
99PHF8_20622853_ChIP-Seq_HELA_Human1.14896402
100P53_21459846_ChIP-Seq_SAOS-2_Human1.14779328
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14029111
102AR_25329375_ChIP-Seq_VCAP_Human1.13470982
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13331996
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12656594
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.10619879
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10426779
107RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09656872
108GATA3_21867929_ChIP-Seq_TH1_Mouse1.09466761
109GATA6_21074721_ChIP-Seq_CACO-2_Human1.09366338
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.09216658
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.09118796
112LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.08395549
113TP53_18474530_ChIP-ChIP_U2OS_Human1.08189030
114RNF2_27304074_Chip-Seq_NSC_Mouse1.08089468
115RUNX_20019798_ChIP-Seq_JUKART_Human1.08069373
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06900208
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.06848769
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05905433
119NFYA_21822215_ChIP-Seq_K562_Human1.05839017
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.05336881
121GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05279048
122GATA1_19941826_ChIP-Seq_K562_Human1.05251388
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04973882
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04757735
125TBL1_22424771_ChIP-Seq_293T_Human1.04420200
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.03657691
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.02930346
128P53_22387025_ChIP-Seq_ESCs_Mouse1.02549690
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.02486089
130STAT3_18555785_ChIP-Seq_MESCs_Mouse1.02403479
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02191267
132SPI1_26923725_Chip-Seq_HPCs_Mouse1.01218771
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01214927
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01052180
135OCT4_19829295_ChIP-Seq_ESCs_Human1.00853984
136SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00075917
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00042253
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99896064
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.99803809
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99752877
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99561294
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99499660
143SPI1_20517297_ChIP-Seq_HL60_Human0.98707011
144KLF4_19829295_ChIP-Seq_ESCs_Human0.97821684
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.97621001
146ERG_20517297_ChIP-Seq_VCAP_Human0.97297685
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96836785
148FUS_26573619_Chip-Seq_HEK293_Human0.96761595
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96704695
150ETV1_20927104_ChIP-Seq_GIST48_Human0.96444287
151GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96032582
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.95553311
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.95388761
154NFYB_21822215_ChIP-Seq_K562_Human0.95261936
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.95197274
156SMRT_27268052_Chip-Seq_Bcells_Human0.95101268
157CTCF_20526341_ChIP-Seq_ESCs_Human0.94133795
158SOX9_26525672_Chip-Seq_HEART_Mouse0.93380539
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93154883
160P300_18555785_Chip-Seq_ESCs_Mouse0.93105276
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.92342238
162CTCF_27219007_Chip-Seq_Bcells_Human0.91399122
163ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91352283
164OCT1_27270436_Chip-Seq_PROSTATE_Human0.90583914
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.88413882
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86544793
167MYC_19829295_ChIP-Seq_ESCs_Human0.86021855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.87495388
2MP0001929_abnormal_gametogenesis5.19612956
3MP0008877_abnormal_DNA_methylation4.06899776
4MP0000569_abnormal_digit_pigmentation3.57439293
5MP0002210_abnormal_sex_determination3.25508036
6MP0002161_abnormal_fertility/fecundity3.22597495
7MP0001348_abnormal_lacrimal_gland2.98791474
8MP0001145_abnormal_male_reproductive2.79825530
9MP0002653_abnormal_ependyma_morphology2.74185710
10MP0005670_abnormal_white_adipose2.49315273
11MP0004510_myositis2.47288395
12MP0000678_abnormal_parathyroid_gland2.45147344
13MP0000653_abnormal_sex_gland2.41106857
14MP0004084_abnormal_cardiac_muscle2.25521345
15MP0004036_abnormal_muscle_relaxation2.23769153
16MP0005451_abnormal_body_composition2.19138773
17MP0005410_abnormal_fertilization15.4180941
18MP0005623_abnormal_meninges_morphology1.84021644
19MP0002234_abnormal_pharynx_morphology1.72250994
20MP0002127_abnormal_cardiovascular_syste1.69963398
21MP0002132_abnormal_respiratory_system1.69503821
22MP0003718_maternal_effect1.67648961
23MP0000749_muscle_degeneration1.57705458
24MP0002822_catalepsy1.52331220
25MP0002160_abnormal_reproductive_system1.51467270
26MP0002249_abnormal_larynx_morphology1.47447538
27MP0004484_altered_response_of1.42280029
28MP0002138_abnormal_hepatobiliary_system1.39865897
29MP0002282_abnormal_trachea_morphology1.38959593
30MP0008995_early_reproductive_senescence1.36306292
31MP0003137_abnormal_impulse_conducting1.34199617
32MP0004233_abnormal_muscle_weight1.34149678
33MP0005167_abnormal_blood-brain_barrier1.33957654
34MP0003646_muscle_fatigue1.29147625
35MP0001485_abnormal_pinna_reflex1.29050232
36MP0009046_muscle_twitch1.25775929
37MP0002735_abnormal_chemical_nociception1.23380308
38MP0004085_abnormal_heartbeat1.22172635
39MP0005375_adipose_tissue_phenotype1.21683420
40MP0005647_abnormal_sex_gland1.17666789
41MP0004145_abnormal_muscle_electrophysio1.16197242
42MP0005620_abnormal_muscle_contractility1.12273212
43MP0000003_abnormal_adipose_tissue1.10166666
44MP0005310_abnormal_salivary_gland1.09883221
45MP0002837_dystrophic_cardiac_calcinosis1.08703601
46MP0001765_abnormal_ion_homeostasis1.02652627
47MP0002972_abnormal_cardiac_muscle0.94634006
48MP0004087_abnormal_muscle_fiber0.94031345
49MP0005083_abnormal_biliary_tract0.92905168
50MP0005379_endocrine/exocrine_gland_phen0.91309815
51MP0002106_abnormal_muscle_physiology0.88258071
52MP0004215_abnormal_myocardial_fiber0.87939729
53MP0001879_abnormal_lymphatic_vessel0.87747266
54MP0001963_abnormal_hearing_physiology0.87209228
55MP0000026_abnormal_inner_ear0.85945771
56MP0005248_abnormal_Harderian_gland0.84497240
57MP0003115_abnormal_respiratory_system0.83553287
58MP0008058_abnormal_DNA_repair0.83020399
59MP0002009_preneoplasia0.83014132
60MP0000759_abnormal_skeletal_muscle0.81528757
61MP0005395_other_phenotype0.81335533
62MP0005369_muscle_phenotype0.80775501
63MP0008057_abnormal_DNA_replication0.79347187
64MP0005330_cardiomyopathy0.78613460
65MP0008775_abnormal_heart_ventricle0.77734751
66MP0010094_abnormal_chromosome_stability0.77690000
67MP0001440_abnormal_grooming_behavior0.73538889
68MP0001984_abnormal_olfaction0.73511751
69MP0001293_anophthalmia0.73469786
70MP0002108_abnormal_muscle_morphology0.73347264
71MP0003950_abnormal_plasma_membrane0.73181809
72MP0010630_abnormal_cardiac_muscle0.72546759
73MP0005423_abnormal_somatic_nervous0.72339874
74MP0009053_abnormal_anal_canal0.70224794
75MP0002796_impaired_skin_barrier0.69828954
76MP0003878_abnormal_ear_physiology0.69629411
77MP0005377_hearing/vestibular/ear_phenot0.69629411
78MP0005535_abnormal_body_temperature0.68877232
79MP0004859_abnormal_synaptic_plasticity0.68545601
80MP0006138_congestive_heart_failure0.68465535
81MP0003111_abnormal_nucleus_morphology0.68018333
82MP0000733_abnormal_muscle_development0.66427450
83MP0004270_analgesia0.63884788
84MP0002229_neurodegeneration0.63621174
85MP0000751_myopathy0.61518528
86MP0002572_abnormal_emotion/affect_behav0.61456475
87MP0005666_abnormal_adipose_tissue0.60909821
88MP0000681_abnormal_thyroid_gland0.60141188
89MP0008569_lethality_at_weaning0.59920151
90MP0002332_abnormal_exercise_endurance0.59028758
91MP0009278_abnormal_bone_marrow0.58339167
92MP0003635_abnormal_synaptic_transmissio0.57452078
93MP0002733_abnormal_thermal_nociception0.56689198
94MP0004811_abnormal_neuron_physiology0.56418094
95MP0005389_reproductive_system_phenotype0.56265425
96MP0003880_abnormal_central_pattern0.55244280
97MP0000955_abnormal_spinal_cord0.55181763
98MP0000358_abnormal_cell_content/0.54110133
99MP0001544_abnormal_cardiovascular_syste0.53937226
100MP0005385_cardiovascular_system_phenoty0.53937226
101MP0000249_abnormal_blood_vessel0.53606985
102MP0003329_amyloid_beta_deposits0.52981705
103MP0005253_abnormal_eye_physiology0.52897916
104MP0005551_abnormal_eye_electrophysiolog0.52623272
105MP0003699_abnormal_female_reproductive0.52300025
106MP0002063_abnormal_learning/memory/cond0.51879506
107MP0000230_abnormal_systemic_arterial0.51398509
108MP0001501_abnormal_sleep_pattern0.50045372
109MP0004130_abnormal_muscle_cell0.49703455
110MP0000747_muscle_weakness0.49467354
111MP0005397_hematopoietic_system_phenotyp0.48756637
112MP0001545_abnormal_hematopoietic_system0.48756637
113MP0008961_abnormal_basal_metabolism0.48532980
114MP0001968_abnormal_touch/_nociception0.47988130
115MP0003786_premature_aging0.47618088
116MP0010368_abnormal_lymphatic_system0.45974793
117MP0002736_abnormal_nociception_after0.45583845
118MP0003011_delayed_dark_adaptation0.45562720
119MP0003861_abnormal_nervous_system0.45010026
120MP0002557_abnormal_social/conspecific_i0.44555158
121MP0008007_abnormal_cellular_replicative0.43450831
122MP0002272_abnormal_nervous_system0.43387758
123MP0000579_abnormal_nail_morphology0.43288504
124MP0005636_abnormal_mineral_homeostasis0.42007789
125MP0001970_abnormal_pain_threshold0.41870336
126MP0005391_vision/eye_phenotype0.41172825
127MP0008770_decreased_survivor_rate0.40877965
128MP0003879_abnormal_hair_cell0.40450966
129MP0001324_abnormal_eye_pigmentation0.40124986
130MP0001851_eye_inflammation0.39748434
131MP0005595_abnormal_vascular_smooth0.39741667
132MP0004742_abnormal_vestibular_system0.39574040
133MP0000049_abnormal_middle_ear0.39461044
134MP0002102_abnormal_ear_morphology0.39365052
135MP0002152_abnormal_brain_morphology0.39354942
136MP0009697_abnormal_copulation0.39238419
137MP0001486_abnormal_startle_reflex0.38884411
138MP0002971_abnormal_brown_adipose0.38479956
139MP0006035_abnormal_mitochondrial_morpho0.37946056
140MP0001502_abnormal_circadian_rhythm0.36129870
141MP0005174_abnormal_tail_pigmentation0.35416867
142MP0009115_abnormal_fat_cell0.34941022
143MP0002269_muscular_atrophy0.34010400
144MP0006276_abnormal_autonomic_nervous0.32726534
145MP0002928_abnormal_bile_duct0.32034290
146MP0003136_yellow_coat_color0.31945571
147MP0003631_nervous_system_phenotype0.31343445
148MP0004019_abnormal_vitamin_homeostasis0.31112087
149MP0002064_seizures0.30931458
150MP0003633_abnormal_nervous_system0.30831450
151MP0002067_abnormal_sensory_capabilities0.30814702
152MP0003045_fibrosis0.28648965
153MP0002169_no_abnormal_phenotype0.26436072
154MP0002873_normal_phenotype0.26274217
155MP0009745_abnormal_behavioral_response0.26028735
156MP0002882_abnormal_neuron_morphology0.25592232
157MP0001119_abnormal_female_reproductive0.25586613
158MP0001730_embryonic_growth_arrest0.24779903
159MP0000462_abnormal_digestive_system0.24779288
160MP0000534_abnormal_ureter_morphology0.24569274
161MP0000566_synostosis0.24324427
162MP0000778_abnormal_nervous_system0.24248717
163MP0001529_abnormal_vocalization0.23969303
164MP0003077_abnormal_cell_cycle0.23792058
165MP0006072_abnormal_retinal_apoptosis0.23661650

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.04863674
2Abnormal respiratory epithelium morphology (HP:0012253)9.04863674
3Abnormal respiratory motile cilium physiology (HP:0012261)8.69200108
4Severe visual impairment (HP:0001141)7.25993706
5Rhinitis (HP:0012384)7.08864618
6Abnormal ciliary motility (HP:0012262)6.89146887
7Infertility (HP:0000789)6.82152077
8Chronic bronchitis (HP:0004469)6.52814018
9Nasal polyposis (HP:0100582)5.76752698
10Male infertility (HP:0003251)5.49386865
11Abnormality of the nasal mucosa (HP:0000433)4.67160369
12Bony spicule pigmentary retinopathy (HP:0007737)4.42911335
13Resting tremor (HP:0002322)4.29174420
14Bronchiectasis (HP:0002110)4.25911774
15Bronchitis (HP:0012387)4.25190010
16Nephronophthisis (HP:0000090)4.19194597
17Ventricular tachycardia (HP:0004756)4.10821111
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02283953
19Chronic hepatic failure (HP:0100626)4.00200794
20Hypoplastic ischia (HP:0003175)3.91070276
21Potter facies (HP:0002009)3.79409147
22Facial shape deformation (HP:0011334)3.79409147
23Abnormal spermatogenesis (HP:0008669)3.70193813
24Abnormality of the ischium (HP:0003174)3.53124064
25Cone-rod dystrophy (HP:0000548)3.30131616
26Impulsivity (HP:0100710)3.24371616
27Recurrent otitis media (HP:0000403)3.23484943
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.20792094
29Abnormality of the renal medulla (HP:0100957)3.19623086
30Enlarged epiphyses (HP:0010580)3.19020355
31Abnormal rod and cone electroretinograms (HP:0008323)3.18211924
32Abnormality of macular pigmentation (HP:0008002)3.16492947
33Recurrent sinusitis (HP:0011108)3.15205757
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.12666312
35Sudden death (HP:0001699)3.07669660
36Postural instability (HP:0002172)2.91987661
37Amelogenesis imperfecta (HP:0000705)2.86248146
38Atrial fibrillation (HP:0005110)2.84576542
39Rhabdomyolysis (HP:0003201)2.78413661
40Tubulointerstitial nephritis (HP:0001970)2.75817291
41Hypoalphalipoproteinemia (HP:0003233)2.74119112
42Recurrent bronchitis (HP:0002837)2.73440672
43Primary atrial arrhythmia (HP:0001692)2.69732059
44Myoglobinuria (HP:0002913)2.69208409
45Type 1 muscle fiber predominance (HP:0003803)2.66471436
46Abnormality of potassium homeostasis (HP:0011042)2.65701296
47Supraventricular tachycardia (HP:0004755)2.57111937
48Heterotopia (HP:0002282)2.54877063
49Abnormality of the left ventricular outflow tract (HP:0011103)2.51337515
50Subaortic stenosis (HP:0001682)2.51337515
51Supraventricular arrhythmia (HP:0005115)2.51004433
52Abnormality of the aortic arch (HP:0012303)2.50205128
53Portal hypertension (HP:0001409)2.49821330
54Muscle hypertrophy of the lower extremities (HP:0008968)2.49455414
55Gonadotropin excess (HP:0000837)2.46149900
56Tubular atrophy (HP:0000092)2.44918465
57Cholecystitis (HP:0001082)2.43679345
58Abnormal gallbladder physiology (HP:0012438)2.43679345
59Hypoplasia of the thymus (HP:0000778)2.40919832
60Distal lower limb muscle weakness (HP:0009053)2.39003657
61Muscle fiber inclusion bodies (HP:0100299)2.38427749
62Abnormality of the parathyroid morphology (HP:0011766)2.38419703
63Azoospermia (HP:0000027)2.31962101
64Tubulointerstitial abnormality (HP:0001969)2.31872261
65Abnormality of the hepatic vasculature (HP:0006707)2.30986706
66Generalized aminoaciduria (HP:0002909)2.30522178
67Exercise-induced myalgia (HP:0003738)2.28870205
68Abnormality of midbrain morphology (HP:0002418)2.27881773
69Molar tooth sign on MRI (HP:0002419)2.27881773
70Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25642573
71Progressive sensorineural hearing impairment (HP:0000408)2.24759294
72Nemaline bodies (HP:0003798)2.24750393
73Abnormality of dental color (HP:0011073)2.23572339
74Choroideremia (HP:0001139)2.21173628
75Spastic tetraparesis (HP:0001285)2.21038233
76Insulin-resistant diabetes mellitus (HP:0000831)2.20181481
77Unilateral renal agenesis (HP:0000122)2.18036999
78Calf muscle hypertrophy (HP:0008981)2.17549630
79Abnormality of the costochondral junction (HP:0000919)2.15102988
80Menstrual irregularities (HP:0000858)2.08676150
81Neoplasm of the heart (HP:0100544)2.08189342
82Dyschromatopsia (HP:0007641)2.07126173
83Muscle fiber splitting (HP:0003555)2.03544891
84Dynein arm defect of respiratory motile cilia (HP:0012255)13.1765680
85Absent/shortened dynein arms (HP:0200106)13.1765680
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4205738
87Decreased central vision (HP:0007663)1.99986857
88Medial flaring of the eyebrow (HP:0010747)1.99881462
89Myokymia (HP:0002411)1.95521281
90Abnormality of the neuromuscular junction (HP:0003398)1.95503813
91Fatigable weakness (HP:0003473)1.95503813
92Abnormality of the calf musculature (HP:0001430)1.93965094
93Polyuria (HP:0000103)1.93658058
94Abnormality of the pubic bones (HP:0003172)1.92303920
95Bradycardia (HP:0001662)1.91530869
96Postaxial foot polydactyly (HP:0001830)1.91294612
97Epiphyseal dysplasia (HP:0002656)1.89152337
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88382547
99Heart block (HP:0012722)1.86763638
100Bowel incontinence (HP:0002607)1.85926698
101Hyponatremia (HP:0002902)1.83966665
102Renovascular hypertension (HP:0100817)1.82528189
103Abnormal EKG (HP:0003115)1.82445779
104Hypoplastic heart (HP:0001961)1.82352708
105Bell-shaped thorax (HP:0001591)1.81621557
106Abnormality of the lower motor neuron (HP:0002366)1.81097150
107Tubulointerstitial fibrosis (HP:0005576)1.80744813
108Stage 5 chronic kidney disease (HP:0003774)1.76719039
109Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74803485
110Neurofibrillary tangles (HP:0002185)1.70231565
111Hemiparesis (HP:0001269)1.67197969
112Abnormality of permanent molar morphology (HP:0011071)1.65824372
113Abnormality of the dental root (HP:0006486)1.65824372
114Taurodontia (HP:0000679)1.65824372
115Abnormal drinking behavior (HP:0030082)1.65702402
116Polydipsia (HP:0001959)1.65702402
117Short ribs (HP:0000773)1.63274299
118Abnormality of molar morphology (HP:0011070)1.58063302
119Abnormality of molar (HP:0011077)1.58063302
120Bile duct proliferation (HP:0001408)1.55483384
121Abnormal biliary tract physiology (HP:0012439)1.55483384
122Absent frontal sinuses (HP:0002688)1.54162710
123Amyotrophic lateral sclerosis (HP:0007354)1.53541520
124Congenital hepatic fibrosis (HP:0002612)1.52587413
125Abnormality of the dental pulp (HP:0006479)1.50307597
126Oculomotor apraxia (HP:0000657)1.47926127
127Renal dysplasia (HP:0000110)1.45805839
128Glucose intolerance (HP:0000833)1.45626433
129Absent epiphyses (HP:0010577)1.45011347
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45011347
131Abnormality of the renal cortex (HP:0011035)1.44887095
132Fibular hypoplasia (HP:0003038)1.44162817
133Truncal obesity (HP:0001956)1.42496635
134Abnormality of renal excretion (HP:0011036)1.41637599
135Cerebral inclusion bodies (HP:0100314)1.40645553
136Hemorrhage of the eye (HP:0011885)1.39819598
137Facial cleft (HP:0002006)1.39250713
138Postaxial hand polydactyly (HP:0001162)1.38527027
139Peripheral hypomyelination (HP:0007182)1.38417552
140Supernumerary spleens (HP:0009799)1.38201335
141Bundle branch block (HP:0011710)1.37148242
142Progressive cerebellar ataxia (HP:0002073)1.32365190
143Attenuation of retinal blood vessels (HP:0007843)1.28267885
144Abnormality of dentin (HP:0010299)1.28228764
145Loss of speech (HP:0002371)1.27000351
146Cystic liver disease (HP:0006706)1.26258580
147Deformed sella turcica (HP:0002681)1.25265555
148J-shaped sella turcica (HP:0002680)1.24618166
149Microglossia (HP:0000171)1.23224054
150Broad distal phalanx of finger (HP:0009836)1.22981947
151Difficulty climbing stairs (HP:0003551)1.21689344
152Optic neuritis (HP:0100653)1.20413517
153Retrobulbar optic neuritis (HP:0100654)1.20413517
154Aplasia/Hypoplasia of the lens (HP:0008063)1.19347041
155EMG: neuropathic changes (HP:0003445)1.18821460
156Double outlet right ventricle (HP:0001719)1.18455524
157Congenital malformation of the right heart (HP:0011723)1.18455524
158Impaired proprioception (HP:0010831)1.18429660
159Abnormality of ocular smooth pursuit (HP:0000617)1.17574725
160Hyporeflexia of lower limbs (HP:0002600)1.17449927
161Short nail (HP:0001799)1.16571394
162Median cleft lip (HP:0000161)1.16413740
163Abnormal urine output (HP:0012590)1.15513867
164Asymmetric septal hypertrophy (HP:0001670)1.15505341
165Hyperkalemia (HP:0002153)1.15039981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.68967555
2PDK37.27819232
3PDK47.27819232
4PRKD36.42194940
5TESK16.23374553
6ICK4.89943266
7PDK24.53085253
8INSRR3.47575142
9BRD42.70359416
10PNCK2.58283846
11MAP4K22.57691910
12PLK22.33905766
13PIK3CG2.28814290
14STK382.18976980
15PTK2B2.17593193
16STK392.13554166
17OBSCN2.11847713
18TTN1.96880932
19WNK41.94140382
20DYRK1B1.62998147
21NEK21.43636057
22KSR21.42906758
23MST1R1.41178015
24TYRO31.40521319
25MAPK151.36015247
26MYLK1.28873656
27AKT31.22816893
28PRKAA21.07061070
29CDK71.03841823
30PDK10.98069957
31WNK10.83711336
32RPS6KA20.81993091
33MAP3K70.81806809
34PINK10.78885443
35TIE10.78250149
36NTRK20.77491820
37PHKG10.77307219
38PHKG20.77307219
39RPS6KL10.75095290
40RPS6KC10.75095290
41ROCK10.74861722
42BRAF0.72365553
43PRKG20.71548853
44CAMK1G0.71523416
45RPS6KA60.71371072
46CAMK10.71246293
47DYRK30.69441155
48DMPK0.69046911
49MAP3K110.68361162
50RIPK40.65067558
51LATS10.64035917
52TRIB30.62411506
53SGK2230.61867585
54SGK4940.61867585
55WEE10.61164410
56MUSK0.59798641
57CAMK1D0.59425600
58NEK60.58956262
59CHEK20.54700593
60MARK20.54115065
61BRSK20.53228007
62PDPK10.51057074
63TTK0.50004746
64CCNB10.48569173
65PAK10.47916723
66MAP2K20.47526686
67CDK40.47480462
68MAP2K60.45722636
69CAMK40.45125302
70CHEK10.43809053
71PASK0.41741359
72STK30.40649961
73MARK10.40617873
74MAP3K80.38705883
75SGK10.38260641
76MAP3K10.37780653
77FGR0.37738716
78PAK20.36441995
79SGK20.36383404
80MAP3K130.35656061
81MAP3K20.35596458
82ATM0.34784718
83LATS20.34163077
84UHMK10.34049936
85PRKAA10.33981185
86TRPM70.33883094
87PRKCG0.32637236
88EEF2K0.32298689
89STK110.30499504
90BRSK10.29585275
91MARK30.29523896
92MTOR0.28454208
93NTRK30.28401834
94CDK150.27561938
95CDK120.26985297
96PLK10.26965382
97AKT10.26047708
98KDR0.25580081
99CDK11A0.25253999
100MAPKAPK50.25061285
101CDC70.24738495
102EPHA40.23770135
103MAPK140.23713440
104CDK180.23549700
105ARAF0.22440598
106PKN20.21690822
107MAP2K10.21647123
108TNK20.21438674
109CAMKK10.21390327
110SIK20.21246408
111TNIK0.20297464
112MAPK110.20212612
113CAMK2A0.19856630
114ATR0.19272704
115FRK0.18770731
116DAPK20.18762339
117GSK3B0.18311385
118PRKCZ0.17483903
119PKN10.17205202
120CDK20.16950900
121MAP3K60.16734528
122CSNK1D0.16190794
123PAK60.15352846
124TESK20.15240874
125CDK10.14876506
126CDK140.14726026
127LMTK20.14458059
128OXSR10.14213007
129CDK30.13765255
130STK100.12556831
131CLK10.12501349
132TAOK10.12376869
133RIPK10.10988324
134RPS6KA10.10762630
135DDR20.10418278
136MAP3K40.09884101
137MAPK80.09743706
138RPS6KB10.09490736
139MAPK100.08882485
140CDK50.08816369
141RPS6KA30.08739737
142CDK60.08564940
143MAPK40.08322460
144MAP3K90.06766929
145PRKCQ0.06558832
146STK38L0.06519209
147GRK50.06004560
148GSK3A0.05982413
149DYRK20.05786584
150PRKCB0.05710641
151CSNK2A10.05161860
152PRKG10.05121456
153MAPK10.04818641

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.52008951
2Fatty acid biosynthesis_Homo sapiens_hsa000614.87181415
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.48968609
4Vitamin B6 metabolism_Homo sapiens_hsa007503.28176479
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75467311
6Linoleic acid metabolism_Homo sapiens_hsa005912.70157867
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.56734529
8Dorso-ventral axis formation_Homo sapiens_hsa043202.45156524
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.44195610
10Glucagon signaling pathway_Homo sapiens_hsa049222.42576256
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42474671
12Butanoate metabolism_Homo sapiens_hsa006502.41892458
13Pyruvate metabolism_Homo sapiens_hsa006202.21071501
14Amphetamine addiction_Homo sapiens_hsa050312.04781711
15Oocyte meiosis_Homo sapiens_hsa041141.99416169
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92910912
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85098529
18Fanconi anemia pathway_Homo sapiens_hsa034601.84718997
19Propanoate metabolism_Homo sapiens_hsa006401.82799177
20Glycerolipid metabolism_Homo sapiens_hsa005611.82151673
21Basal transcription factors_Homo sapiens_hsa030221.77681983
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.76515529
23Phenylalanine metabolism_Homo sapiens_hsa003601.74432497
24Dilated cardiomyopathy_Homo sapiens_hsa054141.73860098
25Mineral absorption_Homo sapiens_hsa049781.66540677
26Cardiac muscle contraction_Homo sapiens_hsa042601.56210450
27Renin secretion_Homo sapiens_hsa049241.54426710
28PPAR signaling pathway_Homo sapiens_hsa033201.53873330
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53669429
30Ether lipid metabolism_Homo sapiens_hsa005651.51177229
31Arginine and proline metabolism_Homo sapiens_hsa003301.47482126
32Huntingtons disease_Homo sapiens_hsa050161.37466687
33Viral myocarditis_Homo sapiens_hsa054161.35526459
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35487283
35mRNA surveillance pathway_Homo sapiens_hsa030151.34931193
36Arginine biosynthesis_Homo sapiens_hsa002201.32099166
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28290275
38Long-term potentiation_Homo sapiens_hsa047201.25385839
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24496158
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21473663
41Nicotine addiction_Homo sapiens_hsa050331.21311259
42Fructose and mannose metabolism_Homo sapiens_hsa000511.21143022
43Salivary secretion_Homo sapiens_hsa049701.15957586
44Estrogen signaling pathway_Homo sapiens_hsa049151.13183512
45Pentose phosphate pathway_Homo sapiens_hsa000301.12701718
46Autoimmune thyroid disease_Homo sapiens_hsa053201.11211013
47RNA transport_Homo sapiens_hsa030131.09461733
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09451253
49Insulin secretion_Homo sapiens_hsa049111.08041327
50Fatty acid metabolism_Homo sapiens_hsa012121.07297755
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07058258
52Allograft rejection_Homo sapiens_hsa053301.05975259
53Synaptic vesicle cycle_Homo sapiens_hsa047211.03952123
54Selenocompound metabolism_Homo sapiens_hsa004501.01576139
55Graft-versus-host disease_Homo sapiens_hsa053321.00109917
56Fat digestion and absorption_Homo sapiens_hsa049750.99799275
57Hedgehog signaling pathway_Homo sapiens_hsa043400.98483467
58Type I diabetes mellitus_Homo sapiens_hsa049400.98364462
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97437058
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96386476
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.96350225
62Taste transduction_Homo sapiens_hsa047420.95718190
63Circadian entrainment_Homo sapiens_hsa047130.90880961
64Cocaine addiction_Homo sapiens_hsa050300.89469790
65Gastric acid secretion_Homo sapiens_hsa049710.89068206
66Calcium signaling pathway_Homo sapiens_hsa040200.88294363
67Thyroid hormone synthesis_Homo sapiens_hsa049180.87879884
68Purine metabolism_Homo sapiens_hsa002300.84849429
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81266955
70cAMP signaling pathway_Homo sapiens_hsa040240.79554381
71Circadian rhythm_Homo sapiens_hsa047100.79454835
72Phototransduction_Homo sapiens_hsa047440.79016805
73Glutamatergic synapse_Homo sapiens_hsa047240.78702701
74Tight junction_Homo sapiens_hsa045300.78411180
75Acute myeloid leukemia_Homo sapiens_hsa052210.78070042
76Collecting duct acid secretion_Homo sapiens_hsa049660.77507077
77Arachidonic acid metabolism_Homo sapiens_hsa005900.76076962
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74901957
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73927407
80Insulin resistance_Homo sapiens_hsa049310.72295616
81Fatty acid degradation_Homo sapiens_hsa000710.70379486
82MAPK signaling pathway_Homo sapiens_hsa040100.68890542
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.67614672
84Renin-angiotensin system_Homo sapiens_hsa046140.67009556
85Endocytosis_Homo sapiens_hsa041440.66655974
86Carbon metabolism_Homo sapiens_hsa012000.66224211
87Cholinergic synapse_Homo sapiens_hsa047250.64832856
88Insulin signaling pathway_Homo sapiens_hsa049100.63744331
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63548446
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62660807
91Inositol phosphate metabolism_Homo sapiens_hsa005620.61918165
92Antigen processing and presentation_Homo sapiens_hsa046120.61371189
93Olfactory transduction_Homo sapiens_hsa047400.60804276
94Pancreatic secretion_Homo sapiens_hsa049720.60670605
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.58920558
96Bile secretion_Homo sapiens_hsa049760.57520790
97Tyrosine metabolism_Homo sapiens_hsa003500.55210147
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53322406
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51364392
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50830771
101Influenza A_Homo sapiens_hsa051640.49810370
102Systemic lupus erythematosus_Homo sapiens_hsa053220.49284917
103Morphine addiction_Homo sapiens_hsa050320.49209010
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49018993
105Sphingolipid metabolism_Homo sapiens_hsa006000.48830338
106VEGF signaling pathway_Homo sapiens_hsa043700.47607945
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47517939
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.47340095
109Vitamin digestion and absorption_Homo sapiens_hsa049770.47270462
110ABC transporters_Homo sapiens_hsa020100.46552178
111AMPK signaling pathway_Homo sapiens_hsa041520.46130370
112Serotonergic synapse_Homo sapiens_hsa047260.44924782
113Biosynthesis of amino acids_Homo sapiens_hsa012300.44419961
114Oxytocin signaling pathway_Homo sapiens_hsa049210.41679375
115Alcoholism_Homo sapiens_hsa050340.41382362
116Wnt signaling pathway_Homo sapiens_hsa043100.41150787
117Adherens junction_Homo sapiens_hsa045200.39001382
118Dopaminergic synapse_Homo sapiens_hsa047280.38682636
119Prolactin signaling pathway_Homo sapiens_hsa049170.38319899
120Glutathione metabolism_Homo sapiens_hsa004800.37859703
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.37051230
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36325025
123Sulfur relay system_Homo sapiens_hsa041220.36310021
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.36196750
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34449334
126Basal cell carcinoma_Homo sapiens_hsa052170.34058291
127Chemical carcinogenesis_Homo sapiens_hsa052040.33214673
128Focal adhesion_Homo sapiens_hsa045100.32683749
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31590266
130Choline metabolism in cancer_Homo sapiens_hsa052310.31414463
131Protein digestion and absorption_Homo sapiens_hsa049740.30524361
132Lysine degradation_Homo sapiens_hsa003100.30267156
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29974712
134HIF-1 signaling pathway_Homo sapiens_hsa040660.29837602
135Type II diabetes mellitus_Homo sapiens_hsa049300.27608820
136Cell cycle_Homo sapiens_hsa041100.26127168
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25687893
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24052369

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