MROH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)6.84852089
2regulation of water loss via skin (GO:0033561)6.01446385
3activation of Rac GTPase activity (GO:0032863)6.01042893
4phospholipid efflux (GO:0033700)5.92231787
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58358032
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.57978497
7L-phenylalanine catabolic process (GO:0006559)5.57978497
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32884676
9L-phenylalanine metabolic process (GO:0006558)5.32884676
10aromatic amino acid family catabolic process (GO:0009074)5.06731274
11response to peptidoglycan (GO:0032494)4.99028850
12positive regulation of Cdc42 GTPase activity (GO:0043089)4.94101262
13urea metabolic process (GO:0019627)4.80522674
14urea cycle (GO:0000050)4.80522674
15high-density lipoprotein particle remodeling (GO:0034375)4.79396759
16alpha-linolenic acid metabolic process (GO:0036109)4.77913497
17cysteine metabolic process (GO:0006534)4.77033020
18kynurenine metabolic process (GO:0070189)4.75883959
19sulfur amino acid catabolic process (GO:0000098)4.68600288
20reverse cholesterol transport (GO:0043691)4.63121080
21indole-containing compound catabolic process (GO:0042436)4.62643821
22indolalkylamine catabolic process (GO:0046218)4.62643821
23tryptophan catabolic process (GO:0006569)4.62643821
24peptidyl-glutamic acid carboxylation (GO:0017187)4.54240641
25protein carboxylation (GO:0018214)4.54240641
26positive regulation of histone deacetylation (GO:0031065)4.53781348
27keratinization (GO:0031424)4.47739420
28bile acid biosynthetic process (GO:0006699)4.40792825
29tryptophan metabolic process (GO:0006568)4.36463778
30mannose metabolic process (GO:0006013)4.36347326
31hemidesmosome assembly (GO:0031581)4.35806422
32negative regulation of erythrocyte differentiation (GO:0045647)4.33611142
33nitrogen cycle metabolic process (GO:0071941)4.30083168
34negative regulation of sterol transport (GO:0032372)4.29875744
35negative regulation of cholesterol transport (GO:0032375)4.29875744
36serine family amino acid catabolic process (GO:0009071)4.29642718
37amino-acid betaine metabolic process (GO:0006577)4.28625440
38negative regulation of fibrinolysis (GO:0051918)4.24298794
39plasma lipoprotein particle assembly (GO:0034377)4.24168518
40regulation of triglyceride catabolic process (GO:0010896)4.21910920
41imidazole-containing compound metabolic process (GO:0052803)4.19979085
42linoleic acid metabolic process (GO:0043651)4.18479407
43plasma lipoprotein particle remodeling (GO:0034369)4.15199338
44protein-lipid complex remodeling (GO:0034368)4.15199338
45macromolecular complex remodeling (GO:0034367)4.15199338
46regulation of protein activation cascade (GO:2000257)4.09489372
47regulation of cholesterol homeostasis (GO:2000188)4.07719529
48glyoxylate metabolic process (GO:0046487)4.07211533
49homocysteine metabolic process (GO:0050667)4.01144110
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99747040
51glycine metabolic process (GO:0006544)3.99406483
52apoptotic process involved in morphogenesis (GO:0060561)3.95161341
53regulation of fibrinolysis (GO:0051917)3.93828045
54complement activation, alternative pathway (GO:0006957)3.93405145
55atrioventricular valve morphogenesis (GO:0003181)3.91799750
56regulation of cholesterol esterification (GO:0010872)3.91503438
57bile acid metabolic process (GO:0008206)3.88895463
58phospholipid homeostasis (GO:0055091)3.88012411
59cholesterol efflux (GO:0033344)3.86039297
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.83492381
61lysine metabolic process (GO:0006553)3.83158495
62lysine catabolic process (GO:0006554)3.83158495
63multicellular organismal water homeostasis (GO:0050891)3.81805729
64regulation of complement activation (GO:0030449)3.77705057
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.77183325
66semaphorin-plexin signaling pathway (GO:0071526)3.75987123
67protein-lipid complex assembly (GO:0065005)3.75749693
68serine family amino acid metabolic process (GO:0009069)3.69736296
69glutamate metabolic process (GO:0006536)3.68871125
70alpha-amino acid catabolic process (GO:1901606)3.68098776
71bile acid and bile salt transport (GO:0015721)3.67865303
72fibrinolysis (GO:0042730)3.67623476
73acylglycerol homeostasis (GO:0055090)3.66146415
74triglyceride homeostasis (GO:0070328)3.66146415
75cell-cell junction maintenance (GO:0045217)3.64752613
76intestinal cholesterol absorption (GO:0030299)3.64645631
77dicarboxylic acid biosynthetic process (GO:0043650)3.63480589
78plasma lipoprotein particle organization (GO:0071827)3.62416518
79serine family amino acid biosynthetic process (GO:0009070)3.61394608
80aromatic amino acid family metabolic process (GO:0009072)3.59869319
81positive regulation of protein deacetylation (GO:0090312)3.59703527
82negative regulation of cell size (GO:0045792)3.57440650
83tyrosine metabolic process (GO:0006570)3.56491010
84plasma lipoprotein particle clearance (GO:0034381)3.56057094
85cellular modified amino acid catabolic process (GO:0042219)3.55736561
86carnitine metabolic process (GO:0009437)3.54988282
87positive regulation of lipid catabolic process (GO:0050996)3.53740183
88cholesterol homeostasis (GO:0042632)3.49540736
89water homeostasis (GO:0030104)3.48000858
90low-density lipoprotein particle remodeling (GO:0034374)3.46554238
91sterol homeostasis (GO:0055092)3.42186493
92lipoprotein metabolic process (GO:0042157)3.41077972
93response to muramyl dipeptide (GO:0032495)3.39652809
94regulation of cholesterol biosynthetic process (GO:0045540)3.39358092
95epithelial cell-cell adhesion (GO:0090136)3.39112930
96protein-lipid complex subunit organization (GO:0071825)3.38286361
97positive regulation of lipoprotein lipase activity (GO:0051006)3.36083750
98positive regulation of triglyceride lipase activity (GO:0061365)3.36083750
99cellular amino acid catabolic process (GO:0009063)3.34738845
100positive regulation of sterol transport (GO:0032373)3.34543102
101positive regulation of cholesterol transport (GO:0032376)3.34543102
102negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.30668204
103negative regulation of viral release from host cell (GO:1902187)3.29616849
104hormone catabolic process (GO:0042447)3.28717436
105GDP-mannose metabolic process (GO:0019673)3.28449600
106regulation of fatty acid beta-oxidation (GO:0031998)3.27255764
107interleukin-1-mediated signaling pathway (GO:0070498)3.25580537
108ethanol oxidation (GO:0006069)3.25020498
109very long-chain fatty acid metabolic process (GO:0000038)3.22722035
110very-low-density lipoprotein particle assembly (GO:0034379)3.22545886
111negative regulation of lipase activity (GO:0060192)3.20430752
112intestinal absorption (GO:0050892)3.19468095
113glucose catabolic process (GO:0006007)3.19440119
114desmosome organization (GO:0002934)3.16850471
115drug catabolic process (GO:0042737)3.16523955
116receptor catabolic process (GO:0032801)3.16071457
117one-carbon metabolic process (GO:0006730)3.16026305
118folic acid-containing compound biosynthetic process (GO:0009396)3.15655400
119regulation of bile acid biosynthetic process (GO:0070857)3.15472236
120citrulline biosynthetic process (GO:0019240)3.13869084
121regulation of ARF GTPase activity (GO:0032312)3.13556957
122regulation of sterol transport (GO:0032371)3.13382569
123regulation of cholesterol transport (GO:0032374)3.13382569
124glucose 6-phosphate metabolic process (GO:0051156)3.13225693
125positive regulation of cholesterol efflux (GO:0010875)3.12913635
126disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.12683600
127bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11629736
128peptidyl-tyrosine autophosphorylation (GO:0038083)3.06862180
129hepatocyte apoptotic process (GO:0097284)3.02041438
130regulation of ruffle assembly (GO:1900027)2.97581266
131positive regulation of Rac GTPase activity (GO:0032855)2.97470488
132regulation of viral release from host cell (GO:1902186)2.97468013
133cell junction maintenance (GO:0034331)2.96936802
134cellular response to virus (GO:0098586)2.94602201
135cell-substrate junction assembly (GO:0007044)2.91680036
136response to food (GO:0032094)2.91520261
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.88553343
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85679615
139regulation of hydrogen peroxide metabolic process (GO:0010310)2.84695966
140regulation of integrin activation (GO:0033623)2.83576054
141germinal center formation (GO:0002467)2.82762116
142branching involved in mammary gland duct morphogenesis (GO:0060444)2.81063073
143regulation of leukocyte degranulation (GO:0043300)2.80362662
144pentose-phosphate shunt (GO:0006098)2.80285986
145neutrophil activation involved in immune response (GO:0002283)2.80130812
146cell-substrate adherens junction assembly (GO:0007045)2.76142302
147focal adhesion assembly (GO:0048041)2.76142302
148regulation of Cdc42 GTPase activity (GO:0043088)2.72503485
149positive regulation of triglyceride metabolic process (GO:0090208)2.72423031
150regulation of chromatin binding (GO:0035561)2.72073383
151detection of bacterium (GO:0016045)2.71854196
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71334144
153amyloid precursor protein metabolic process (GO:0042982)2.67853272
154phospholipid scrambling (GO:0017121)2.67283141
155proline biosynthetic process (GO:0006561)2.64508918
156regulation of glucose import in response to insulin stimulus (GO:2001273)2.63647298
157protein retention in ER lumen (GO:0006621)2.63315498
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61896352
159detection of other organism (GO:0098543)2.61431518
160regulation of interferon-beta biosynthetic process (GO:0045357)2.60270132
161negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.59933697
162positive regulation of receptor recycling (GO:0001921)2.59216699
163regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59197351
164histone H4 deacetylation (GO:0070933)2.58933641
165negative regulation of interleukin-8 production (GO:0032717)2.57212069
166snRNA metabolic process (GO:0016073)2.57177431
167myelin maintenance (GO:0043217)2.56577809
168protein kinase C signaling (GO:0070528)2.53175145
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52871866
170chaperone mediated protein folding requiring cofactor (GO:0051085)2.52827817
171maternal placenta development (GO:0001893)2.52589432
172striated muscle atrophy (GO:0014891)2.52303945
173citrulline metabolic process (GO:0000052)2.52118275
174cell differentiation involved in embryonic placenta development (GO:0060706)2.51755184
175osteoblast development (GO:0002076)2.51693239
176Rho protein signal transduction (GO:0007266)2.50088421
177epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49796690
178NIK/NF-kappaB signaling (GO:0038061)2.49204278
179macrophage activation involved in immune response (GO:0002281)2.48522486
180regulation of endothelial cell chemotaxis (GO:2001026)2.46558665
181apoptotic process involved in development (GO:1902742)2.45912052
182regulation of histone deacetylation (GO:0031063)2.44716648
183positive regulation of CREB transcription factor activity (GO:0032793)2.44240634
184pinocytosis (GO:0006907)2.44169119
185adherens junction assembly (GO:0034333)2.43679582
186regulation of mast cell degranulation (GO:0043304)2.43119393
187establishment of apical/basal cell polarity (GO:0035089)2.42865576
188activation of JUN kinase activity (GO:0007257)2.42791539
189response to progesterone (GO:0032570)2.42619368
190protein localization to endosome (GO:0036010)2.42008036
191negative regulation of granulocyte differentiation (GO:0030853)2.40431648
192positive regulation of epidermal cell differentiation (GO:0045606)2.40389230
193negative regulation of fatty acid transport (GO:2000192)2.40148467
194regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38303962
195regulation of cholesterol metabolic process (GO:0090181)2.36860478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.17707312
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.87307765
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.64481409
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.23828851
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.43229827
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.41843498
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.86511006
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50259583
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34619517
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18630941
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02717118
12ZNF263_19887448_ChIP-Seq_K562_Human2.81335952
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.80086487
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.40547198
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35857843
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.12846057
17VDR_24763502_ChIP-Seq_THP-1_Human1.94272674
18E2F7_22180533_ChIP-Seq_HELA_Human1.87063327
19CLOCK_20551151_ChIP-Seq_293T_Human1.82022902
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75914738
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71535606
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67586455
23KDM2B_26808549_Chip-Seq_K562_Human1.65105178
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63813984
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60057579
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57535338
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55858486
28SA1_27219007_Chip-Seq_ERYTHROID_Human1.54802718
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54762352
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54300843
31SMC4_20622854_ChIP-Seq_HELA_Human1.53975630
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53673328
33MAF_26560356_Chip-Seq_TH1_Human1.52833307
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.51952458
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49263564
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.48271095
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47957430
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.47723780
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47260274
40CREB1_26743006_Chip-Seq_LNCaP_Human1.46959027
41MAF_26560356_Chip-Seq_TH2_Human1.46578645
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46390333
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45448666
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43059974
45LXR_22292898_ChIP-Seq_THP-1_Human1.40065695
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38983653
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38884816
48BCL6_27268052_Chip-Seq_Bcells_Human1.38603001
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.38191651
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35595951
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.34890605
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.33938971
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.33838636
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33700781
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33004450
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31840969
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31545313
58VDR_21846776_ChIP-Seq_THP-1_Human1.30990007
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.30876602
60UTX_26944678_Chip-Seq_JUKART_Human1.30400049
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29458344
62GATA6_25053715_ChIP-Seq_YYC3_Human1.26985000
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26326597
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.26251237
65GATA4_25053715_ChIP-Seq_YYC3_Human1.24317551
66MYC_22102868_ChIP-Seq_BL_Human1.22824996
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21715685
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20587012
69GATA1_19941826_ChIP-Seq_K562_Human1.20455278
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19257345
71RARB_24833708_ChIP-Seq_LIVER_Mouse1.18482392
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18384260
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17840366
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17277941
75ATF3_27146783_Chip-Seq_COLON_Human1.17260081
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17035497
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15605766
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15280068
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15058083
80TP53_22127205_ChIP-Seq_IMR90_Human1.14508959
81TCF7_22412390_ChIP-Seq_EML_Mouse1.13357823
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12698643
83RACK7_27058665_Chip-Seq_MCF-7_Human1.12364313
84GATA1_22025678_ChIP-Seq_K562_Human1.12118099
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11241432
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10635233
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10511870
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09467879
89PHF8_20622854_ChIP-Seq_HELA_Human1.08881058
90SCL_19346495_ChIP-Seq_HPC-7_Human1.08469258
91CTCF_27219007_Chip-Seq_Bcells_Human1.08390212
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07338632
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07175722
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07175722
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06938062
96RARA_24833708_ChIP-Seq_LIVER_Mouse1.04388877
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03574817
98CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02525631
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02413164
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02286546
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01919298
102CTCF_21964334_Chip-Seq_Bcells_Human1.01039075
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00939152
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00785620
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00490562
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00022109
107KLF5_25053715_ChIP-Seq_YYC3_Human0.99525438
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99420868
109FOXA2_19822575_ChIP-Seq_HepG2_Human0.99319305
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99148360
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.98230253
112GATA2_19941826_ChIP-Seq_K562_Human0.97671396
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97511540
114SA1_27219007_Chip-Seq_Bcells_Human0.97249793
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.96013826
116BCOR_27268052_Chip-Seq_Bcells_Human0.89861266
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89485197
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89254120
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.88471632
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88142940
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88087962
122NCOR1_26117541_ChIP-Seq_K562_Human0.87980136
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85100863
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83933940
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83898438
126CEBPB_22108803_ChIP-Seq_LS180_Human0.82751219
127EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82615552
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82268552
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80520549
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.78670070
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77631393
132KDM2B_26808549_Chip-Seq_DND41_Human0.76948946
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76722985
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75132488
135AR_21909140_ChIP-Seq_LNCAP_Human0.74547939
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72445754
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72313451
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71360062
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71343709
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71151942
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71057571
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.70193633
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69868971
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69428680
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69253010
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68971411
147E2F1_20622854_ChIP-Seq_HELA_Human0.68692967
148P68_20966046_ChIP-Seq_HELA_Human0.68560932
149TP63_22573176_ChIP-Seq_HFKS_Human0.68496426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.22423395
2MP0002139_abnormal_hepatobiliary_system5.08503786
3MP0005085_abnormal_gallbladder_physiolo4.53537797
4MP0002796_impaired_skin_barrier4.25151192
5MP0005365_abnormal_bile_salt3.95524043
6MP0003705_abnormal_hypodermis_morpholog3.81027658
7MP0003191_abnormal_cellular_cholesterol3.64777723
8MP0002254_reproductive_system_inflammat3.63888730
9MP0003806_abnormal_nucleotide_metabolis3.41710605
10MP0008875_abnormal_xenobiotic_pharmacok3.36936550
11MP0005083_abnormal_biliary_tract2.92267828
12MP0003941_abnormal_skin_development2.82754724
13MP0009840_abnormal_foam_cell2.81278882
14MP0005501_abnormal_skin_physiology2.78387509
15MP0005275_abnormal_skin_tensile2.73932624
16MP0003252_abnormal_bile_duct2.73725606
17MP0010329_abnormal_lipoprotein_level2.73291050
18MP0005451_abnormal_body_composition2.66867630
19MP0000566_synostosis2.66426258
20MP0000579_abnormal_nail_morphology2.46015684
21MP0005058_abnormal_lysosome_morphology2.35197546
22MP0010234_abnormal_vibrissa_follicle2.31267564
23MP0003172_abnormal_lysosome_physiology2.13060221
24MP0001666_abnormal_nutrient_absorption2.05560404
25MP0008260_abnormal_autophagy2.01359183
26MP0002060_abnormal_skin_morphology2.00116622
27MP0004947_skin_inflammation1.90008658
28MP0001216_abnormal_epidermal_layer1.79893547
29MP0000609_abnormal_liver_physiology1.79523807
30MP0005409_darkened_coat_color1.76099992
31MP0003656_abnormal_erythrocyte_physiolo1.67966108
32MP0002877_abnormal_melanocyte_morpholog1.66299153
33MP0002396_abnormal_hematopoietic_system1.64651639
34MP0004019_abnormal_vitamin_homeostasis1.61743357
35MP0009379_abnormal_foot_pigmentation1.60248191
36MP0009278_abnormal_bone_marrow1.57792903
37MP0000678_abnormal_parathyroid_gland1.52358541
38MP0003303_peritoneal_inflammation1.50119838
39MP0004185_abnormal_adipocyte_glucose1.49827011
40MP0005332_abnormal_amino_acid1.48823733
41MP0003453_abnormal_keratinocyte_physiol1.47913204
42MP0002118_abnormal_lipid_homeostasis1.47345605
43MP0002419_abnormal_innate_immunity1.37065809
44MP0000467_abnormal_esophagus_morphology1.37040329
45MP0010771_integument_phenotype1.33237835
46MP0002249_abnormal_larynx_morphology1.31934650
47MP0005025_abnormal_response_to1.28477312
48MP0003195_calcinosis1.22029057
49MP0000490_abnormal_crypts_of1.21256610
50MP0009333_abnormal_splenocyte_physiolog1.21082308
51MP0009931_abnormal_skin_appearance1.20738704
52MP0005076_abnormal_cell_differentiation1.17145967
53MP0001664_abnormal_digestion1.10458237
54MP0005319_abnormal_enzyme/_coenzyme1.09710668
55MP0004264_abnormal_extraembryonic_tissu1.09123985
56MP0003566_abnormal_cell_adhesion1.07885017
57MP0001243_abnormal_dermal_layer1.07419095
58MP0004858_abnormal_nervous_system1.06570972
59MP0000377_abnormal_hair_follicle1.02111886
60MP0005310_abnormal_salivary_gland1.01648542
61MP0003763_abnormal_thymus_physiology1.01270950
62MP0010352_gastrointestinal_tract_polyps0.99618496
63MP0002098_abnormal_vibrissa_morphology0.99517646
64MP0003123_paternal_imprinting0.98096416
65MP0001348_abnormal_lacrimal_gland0.96336224
66MP0009764_decreased_sensitivity_to0.94659909
67MP0001764_abnormal_homeostasis0.91786230
68MP0001819_abnormal_immune_cell0.91224368
69MP0000598_abnormal_liver_morphology0.91101310
70MP0002420_abnormal_adaptive_immunity0.89055060
71MP0000685_abnormal_immune_system0.88888029
72MP0000604_amyloidosis0.88210378
73MP0005647_abnormal_sex_gland0.88170538
74MP0000470_abnormal_stomach_morphology0.88104821
75MP0000647_abnormal_sebaceous_gland0.86647627
76MP0001191_abnormal_skin_condition0.86465915
77MP0002452_abnormal_antigen_presenting0.85287315
78MP0009643_abnormal_urine_homeostasis0.85147162
79MP0001533_abnormal_skeleton_physiology0.84838270
80MP0000537_abnormal_urethra_morphology0.82944161
81MP0002723_abnormal_immune_serum0.82840723
82MP0010678_abnormal_skin_adnexa0.82560385
83MP0009053_abnormal_anal_canal0.82545077
84MP0005621_abnormal_cell_physiology0.81687753
85MP0004808_abnormal_hematopoietic_stem0.81261775
86MP0002089_abnormal_postnatal_growth/wei0.80405052
87MP0000465_gastrointestinal_hemorrhage0.80122631
88MP0003866_abnormal_defecation0.78591362
89MP0005666_abnormal_adipose_tissue0.78055263
90MP0001873_stomach_inflammation0.77817346
91MP0003878_abnormal_ear_physiology0.76466337
92MP0005377_hearing/vestibular/ear_phenot0.76466337
93MP0003183_abnormal_peptide_metabolism0.76186792
94MP0000427_abnormal_hair_cycle0.75841048
95MP0005464_abnormal_platelet_physiology0.75553714
96MP0002398_abnormal_bone_marrow0.75494809
97MP0001849_ear_inflammation0.74984039
98MP0004381_abnormal_hair_follicle0.73249471
99MP0002138_abnormal_hepatobiliary_system0.72973607
100MP0003045_fibrosis0.72591040
101MP0009763_increased_sensitivity_to0.72539746
102MP0009672_abnormal_birth_weight0.72451381
103MP0005397_hematopoietic_system_phenotyp0.71973336
104MP0001545_abnormal_hematopoietic_system0.71973336
105MP0002148_abnormal_hypersensitivity_rea0.71859045
106MP0000477_abnormal_intestine_morphology0.71751783
107MP0005000_abnormal_immune_tolerance0.71648426
108MP0005584_abnormal_enzyme/coenzyme_acti0.71068918
109MP0002405_respiratory_system_inflammati0.71004775
110MP0002429_abnormal_blood_cell0.70806077
111MP0001835_abnormal_antigen_presentation0.70441709
112MP0001765_abnormal_ion_homeostasis0.70402046
113MP0005670_abnormal_white_adipose0.70122228
114MP0000716_abnormal_immune_system0.70057599
115MP0001800_abnormal_humoral_immune0.69628332
116MP0001845_abnormal_inflammatory_respons0.69542716
117MP0003091_abnormal_cell_migration0.69344690
118MP0002998_abnormal_bone_remodeling0.69215230
119MP0005023_abnormal_wound_healing0.68038712
120MP0003436_decreased_susceptibility_to0.67902306
121MP0002086_abnormal_extraembryonic_tissu0.66733181
122MP0000367_abnormal_coat/_hair0.66410900
123MP0008961_abnormal_basal_metabolism0.65831387
124MP0002971_abnormal_brown_adipose0.65094466
125MP0003828_pulmonary_edema0.64804212
126MP0005375_adipose_tissue_phenotype0.64217510
127MP0004782_abnormal_surfactant_physiolog0.64159343
128MP0003300_gastrointestinal_ulcer0.63214472
129MP0002132_abnormal_respiratory_system0.61835359
130MP0001853_heart_inflammation0.61717822
131MP0003868_abnormal_feces_composition0.61006886
132MP0010307_abnormal_tumor_latency0.56274112
133MP0000383_abnormal_hair_follicle0.55814995
134MP0005334_abnormal_fat_pad0.54337369
135MP0004130_abnormal_muscle_cell0.52316317
136MP0008438_abnormal_cutaneous_collagen0.52096129
137MP0008469_abnormal_protein_level0.51543873
138MP0003186_abnormal_redox_activity0.51484133
139MP0001346_abnormal_lacrimal_gland0.50213147
140MP0000762_abnormal_tongue_morphology0.50111549
141MP0003950_abnormal_plasma_membrane0.48710078
142MP0009642_abnormal_blood_homeostasis0.47147715
143MP0009765_abnormal_xenobiotic_induced0.47096136
144MP0001915_intracranial_hemorrhage0.46111175
145MP0002136_abnormal_kidney_physiology0.45733174
146MP0000858_altered_metastatic_potential0.45521380
147MP0009384_cardiac_valve_regurgitation0.44776079
148MP0005636_abnormal_mineral_homeostasis0.43327079
149MP0005266_abnormal_metabolism0.43010405
150MP0010155_abnormal_intestine_physiology0.42763282
151MP0009115_abnormal_fat_cell0.42217529
152MP0002697_abnormal_eye_size0.41933584
153MP0000003_abnormal_adipose_tissue0.41421893
154MP0005376_homeostasis/metabolism_phenot0.40294056
155MP0002970_abnormal_white_adipose0.39236957
156MP0005174_abnormal_tail_pigmentation0.38754916

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.97009722
2Xanthomatosis (HP:0000991)5.44204279
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.41788158
4Deep venous thrombosis (HP:0002625)5.38439453
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.83782170
6Hypobetalipoproteinemia (HP:0003563)4.48331362
7Hypoalphalipoproteinemia (HP:0003233)4.37655811
8Prolonged partial thromboplastin time (HP:0003645)4.29091291
9Hyperlipoproteinemia (HP:0010980)4.25740633
10Hypolipoproteinemia (HP:0010981)4.18626606
11Abnormality of nail color (HP:0100643)4.12749555
12Myocardial infarction (HP:0001658)4.04114501
13Distal lower limb amyotrophy (HP:0008944)3.91760064
14Gangrene (HP:0100758)3.83661375
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74320150
16Increased IgE level (HP:0003212)3.73208465
17Broad face (HP:0000283)3.69533808
18Epidermoid cyst (HP:0200040)3.68398934
19Complement deficiency (HP:0004431)3.62864113
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.58038468
21Eczematoid dermatitis (HP:0000976)3.47355609
22Thin bony cortex (HP:0002753)3.45782726
23Hyperammonemia (HP:0001987)3.43018787
24Abnormality of pyrimidine metabolism (HP:0004353)3.41686313
25Congenital ichthyosiform erythroderma (HP:0007431)3.41157053
26Upper limb amyotrophy (HP:0009129)3.36076869
27Distal upper limb amyotrophy (HP:0007149)3.36076869
28Joint hemorrhage (HP:0005261)3.32889035
29Hyperglycinuria (HP:0003108)3.28891406
30Easy fatigability (HP:0003388)3.28433835
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18956877
32Plantar hyperkeratosis (HP:0007556)3.17249559
33Right ventricular cardiomyopathy (HP:0011663)3.11655923
34Abnormality of the common coagulation pathway (HP:0010990)3.07809390
35J-shaped sella turcica (HP:0002680)3.07288505
36Reticulocytosis (HP:0001923)3.03975722
37Abnormality of methionine metabolism (HP:0010901)3.03527236
38Fat malabsorption (HP:0002630)3.00251182
39Abnormality of glycine metabolism (HP:0010895)2.99998115
40Abnormality of serine family amino acid metabolism (HP:0010894)2.99998115
41Hypotrichosis (HP:0001006)2.99755198
42Abnormality of complement system (HP:0005339)2.99649661
43Hyperglycinemia (HP:0002154)2.97638129
44Palmoplantar hyperkeratosis (HP:0000972)2.95380060
45Spastic diplegia (HP:0001264)2.94202680
46Hypoglycemic coma (HP:0001325)2.93282214
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.93033493
48Hypercholesterolemia (HP:0003124)2.87339020
49Ketosis (HP:0001946)2.86874166
50Hyperbilirubinemia (HP:0002904)2.86473328
51Conjugated hyperbilirubinemia (HP:0002908)2.83643752
52Palmar hyperkeratosis (HP:0010765)2.83229339
53Pseudobulbar signs (HP:0002200)2.81616301
54Hyperacusis (HP:0010780)2.74680135
55Ulnar bowing (HP:0003031)2.70817433
56Ectropion (HP:0000656)2.63960886
57Abnormality of the intrinsic pathway (HP:0010989)2.62809872
58Woolly hair (HP:0002224)2.60240291
59Onycholysis (HP:0001806)2.60101799
60Acanthocytosis (HP:0001927)2.57522949
61Vascular calcification (HP:0004934)2.56890602
62Abnormality of nucleobase metabolism (HP:0010932)2.55752047
63Cervical subluxation (HP:0003308)2.55470481
64Axonal loss (HP:0003447)2.52947865
65Obstructive sleep apnea (HP:0002870)2.51721140
66Poikilocytosis (HP:0004447)2.49154809
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.48251418
68Ridged nail (HP:0001807)2.48117487
69Increased cerebral lipofuscin (HP:0011813)2.47110663
70Cellulitis (HP:0100658)2.46983266
71Recurrent bacterial skin infections (HP:0005406)2.46470065
72Thick nail (HP:0001805)2.45476303
73Cheilitis (HP:0100825)2.44103184
74Increased connective tissue (HP:0009025)2.43592327
75Delayed CNS myelination (HP:0002188)2.43454712
76Pruritus (HP:0000989)2.41447194
77Focal segmental glomerulosclerosis (HP:0000097)2.37628731
78Malnutrition (HP:0004395)2.36703156
79Fragile skin (HP:0001030)2.36533922
80Flat acetabular roof (HP:0003180)2.35085177
81Hypochromic microcytic anemia (HP:0004840)2.34460092
82Alopecia of scalp (HP:0002293)2.34323846
83Cardiovascular calcification (HP:0011915)2.34226327
84Stridor (HP:0010307)2.33937315
85Lower limb amyotrophy (HP:0007210)2.31155314
86Fragile nails (HP:0001808)2.25232071
87Pustule (HP:0200039)2.25022924
88Recurrent abscess formation (HP:0002722)2.23042421
89Abnormality of the thoracic spine (HP:0100711)2.21683993
90Erythroderma (HP:0001019)2.21445688
91Hypertriglyceridemia (HP:0002155)2.21389016
92Abnormality of reticulocytes (HP:0004312)2.20767812
93Milia (HP:0001056)2.17045163
94Abnormality of macrophages (HP:0004311)2.16778232
95Hepatocellular carcinoma (HP:0001402)2.16643150
96Esophageal varix (HP:0002040)2.15993768
97Metaphyseal cupping (HP:0003021)2.15671300
98Skin nodule (HP:0200036)2.15477630
99Thoracic kyphosis (HP:0002942)2.15310198
100Lack of skin elasticity (HP:0100679)2.14760705
101Ketoacidosis (HP:0001993)2.13164312
102Abnormality of purine metabolism (HP:0004352)2.12784914
103Nail dystrophy (HP:0008404)2.12631145
104Achilles tendon contracture (HP:0001771)2.11192233
105Micronodular cirrhosis (HP:0001413)2.09444714
106Glomerulosclerosis (HP:0000096)2.09218173
107Neonatal onset (HP:0003623)2.06239410
108Obstructive lung disease (HP:0006536)2.05509989
109Chronic obstructive pulmonary disease (HP:0006510)2.05509989
110Abnormal blistering of the skin (HP:0008066)2.04711973
111Abnormality of iron homeostasis (HP:0011031)2.03327271
112Abnormal hair laboratory examination (HP:0003328)2.03213049
113Seborrheic dermatitis (HP:0001051)2.02708323
114Breast hypoplasia (HP:0003187)2.01794350
115Increased serum ferritin (HP:0003281)2.00022844
116Cholelithiasis (HP:0001081)1.98752662
117Advanced eruption of teeth (HP:0006288)1.98521559
118Erythema (HP:0010783)1.98253133
119Abnormality of transition element cation homeostasis (HP:0011030)1.97769588
120Cerebral aneurysm (HP:0004944)1.97583561
121Slow saccadic eye movements (HP:0000514)1.96868362
122Polygenic inheritance (HP:0010982)1.96704743
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96408916
124Abdominal distention (HP:0003270)1.96238649
125Pili torti (HP:0003777)1.94907513
126Trismus (HP:0000211)1.94788205
127Abnormal gallbladder morphology (HP:0012437)1.94098216
128Mildly elevated creatine phosphokinase (HP:0008180)1.93865899
129Gingivitis (HP:0000230)1.93681342
130Diaphragmatic weakness (HP:0009113)1.93519591
131Steatorrhea (HP:0002570)1.91966997
132Late onset (HP:0003584)1.91361291
133Amelogenesis imperfecta (HP:0000705)1.90785131
134Parakeratosis (HP:0001036)1.90628228
135Difficulty climbing stairs (HP:0003551)1.90549942
136Curly hair (HP:0002212)1.89291613
137Long palpebral fissure (HP:0000637)1.89014097
138Acanthosis nigricans (HP:0000956)1.88880577
139Pathologic fracture (HP:0002756)1.88530173
140Selective tooth agenesis (HP:0001592)1.87808524
141Distal lower limb muscle weakness (HP:0009053)1.87567846
142Cholecystitis (HP:0001082)1.85987352
143Abnormal gallbladder physiology (HP:0012438)1.85987352
144Myopathic facies (HP:0002058)1.85616406
145Corneal erosion (HP:0200020)1.85474327
146Dysostosis multiplex (HP:0000943)1.85440011
147Joint stiffness (HP:0001387)1.84502679
148Increased mean platelet volume (HP:0011877)1.83316474
149Conjunctival hamartoma (HP:0100780)1.83205277
150Ureteral stenosis (HP:0000071)1.82687682
151Gingival bleeding (HP:0000225)1.82536965
152Squamous cell carcinoma (HP:0002860)1.81287972
153Recurrent skin infections (HP:0001581)1.81261917
154Hemorrhage of the eye (HP:0011885)1.81124895
155Mucopolysacchariduria (HP:0008155)1.81015114
156Urinary glycosaminoglycan excretion (HP:0003541)1.81015114
157Septate vagina (HP:0001153)1.80752476
158Abnormality of the Achilles tendon (HP:0005109)1.80185710
159Poikiloderma (HP:0001029)1.80101488
160Abnormality of the fingertips (HP:0001211)1.79391223
161Abnormality of polysaccharide metabolism (HP:0011012)1.79311379
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79311379
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79311379
164Upper motor neuron abnormality (HP:0002127)1.78675937
165Thrombophlebitis (HP:0004418)1.78601143
166Bulbar palsy (HP:0001283)1.78471068
167Dehydration (HP:0001944)1.78339725
168Rickets (HP:0002748)1.78193087
169Onion bulb formation (HP:0003383)1.77530250
170Hypertensive crisis (HP:0100735)1.76888860
171Premature loss of primary teeth (HP:0006323)1.75702142
172Annular pancreas (HP:0001734)1.73830468
173Progressive sensorineural hearing impairment (HP:0000408)1.73415546
174Short nail (HP:0001799)1.73413150
175Gastrointestinal inflammation (HP:0004386)1.72849484
176Abnormality of the distal phalanges of the toes (HP:0010182)1.72112957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.97359663
2MST1R3.95563756
3PKN23.25905348
4TRIB33.16746389
5ERN13.04098669
6CDK123.03884243
7EPHA23.01976993
8BCKDK2.50101116
9LMTK22.39137771
10FLT32.36613312
11MAPKAPK32.34870427
12MAP3K102.22892154
13SMG12.11444883
14SIK12.11414569
15TAOK31.99810928
16ERBB41.99504912
17MET1.96183268
18PRPF4B1.92596481
19INSRR1.88111538
20BLK1.88038864
21IRAK21.74366317
22MAP3K111.74025454
23RPS6KB21.68051159
24IRAK31.67061119
25FGFR41.64450280
26PIM21.63225489
27MAP2K31.59854013
28MAPK111.56703511
29TNK21.48341153
30STK101.47458813
31LATS11.43550049
32MAP3K31.38003953
33PTK61.37812992
34FGFR11.35762549
35NME21.28754084
36TAOK11.27926691
37BRD41.27669677
38TTN1.27215836
39ICK1.25849695
40MAP2K21.24695300
41CDK61.22835267
42SIK21.21159192
43TGFBR21.16219267
44PIM11.12794145
45EPHB11.10335101
46RIPK41.10311549
47MARK21.09704101
48PRKD21.08447129
49GRK61.05954719
50MTOR1.03394928
51PTK20.94111439
52IRAK10.93947877
53SIK30.93302845
54PIK3CG0.93065617
55TYK20.92465837
56MAP4K10.88372300
57TAOK20.86213693
58ERBB20.85329563
59PRKCI0.84714444
60NEK20.83939961
61MAPK150.83548107
62MAP3K90.81735256
63MAP3K130.79415942
64PRKG20.78877089
65TRPM70.78181959
66PAK20.76033058
67STK40.75805784
68MAP3K80.75598904
69RIPK10.74619070
70ZAP700.73304511
71PDPK10.71565226
72CAMK1D0.71501413
73BMX0.70615622
74BTK0.70240367
75MAPK40.69695455
76JAK20.64936836
77CDC42BPA0.64515448
78ITK0.64401502
79MATK0.63986273
80CSK0.63663366
81CSF1R0.62529719
82STK30.62141968
83PRKAA20.59370648
84MAP3K60.58104120
85GSK3A0.57789836
86PRKD30.57587656
87RPS6KA40.57493913
88LRRK20.57409195
89MAP3K20.55690250
90PDGFRA0.54485644
91MAP3K70.53707807
92TESK10.53103570
93EPHB20.51654745
94HIPK20.50152723
95CDK70.50004178
96CDK40.49454420
97ARAF0.48411138
98TEC0.47853256
99NME10.47124999
100NEK10.47002691
101IKBKB0.46969525
102MAP2K60.46672896
103CDK80.46543366
104JAK30.46481903
105DYRK1B0.46377341
106TLK10.45616625
107FER0.45356209
108IKBKE0.44713410
109NTRK10.43825968
110PAK40.43414428
111DAPK20.43153115
112TESK20.42862483
113MAPK120.41328054
114ALK0.40076861
115MUSK0.40043071
116MAPK30.39949429
117DDR20.38185987
118IRAK40.38050201
119MST40.37706832
120RPS6KC10.37641387
121RPS6KL10.37641387
122MAP3K140.36324074
123FGR0.34346778
124CHUK0.34077345
125RPS6KA20.33805645
126MAP3K50.33600523
127MAPKAPK20.33295951
128MAP2K40.33240218
129TBK10.32445761
130AKT20.32145953
131MAP3K10.31315162
132RPS6KA60.30927351
133MAPK10.29444214
134KSR20.29374399
135PDK10.26421366
136STK380.26027154
137PTK2B0.24818559
138CDK90.23472709
139RPS6KA10.23463161
140WNK40.22920056
141MAP2K10.22545302

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94247363
2Nitrogen metabolism_Homo sapiens_hsa009103.50478975
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18536312
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10674177
5Arginine biosynthesis_Homo sapiens_hsa002202.79565897
6Notch signaling pathway_Homo sapiens_hsa043302.45863020
7Complement and coagulation cascades_Homo sapiens_hsa046102.42754321
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40279501
9Tryptophan metabolism_Homo sapiens_hsa003802.39772381
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37316127
11Histidine metabolism_Homo sapiens_hsa003402.36873302
12Fatty acid degradation_Homo sapiens_hsa000712.31660817
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20680668
14ABC transporters_Homo sapiens_hsa020102.03339176
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00520010
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99383810
17Caffeine metabolism_Homo sapiens_hsa002321.98214591
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93687885
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91542045
20VEGF signaling pathway_Homo sapiens_hsa043701.91309351
21Staphylococcus aureus infection_Homo sapiens_hsa051501.89891692
22beta-Alanine metabolism_Homo sapiens_hsa004101.83777683
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82297320
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.80605986
25Chemical carcinogenesis_Homo sapiens_hsa052041.77833463
26Selenocompound metabolism_Homo sapiens_hsa004501.74319597
27Phenylalanine metabolism_Homo sapiens_hsa003601.73616006
28PPAR signaling pathway_Homo sapiens_hsa033201.73061313
29Fat digestion and absorption_Homo sapiens_hsa049751.69874161
30Peroxisome_Homo sapiens_hsa041461.66772014
31One carbon pool by folate_Homo sapiens_hsa006701.64365402
32Sulfur relay system_Homo sapiens_hsa041221.62059871
33Fatty acid metabolism_Homo sapiens_hsa012121.59216186
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53763661
35Non-small cell lung cancer_Homo sapiens_hsa052231.51551780
36Folate biosynthesis_Homo sapiens_hsa007901.48864873
37Butanoate metabolism_Homo sapiens_hsa006501.48619676
38Starch and sucrose metabolism_Homo sapiens_hsa005001.46694633
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44890436
40Pancreatic cancer_Homo sapiens_hsa052121.44874608
41Retinol metabolism_Homo sapiens_hsa008301.44621616
42B cell receptor signaling pathway_Homo sapiens_hsa046621.41556600
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40238078
44Osteoclast differentiation_Homo sapiens_hsa043801.40213684
45Bile secretion_Homo sapiens_hsa049761.39977228
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.39676799
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37532550
48Leishmaniasis_Homo sapiens_hsa051401.35004789
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34432914
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31861513
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.31790425
52Tyrosine metabolism_Homo sapiens_hsa003501.31415944
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.30347410
54Propanoate metabolism_Homo sapiens_hsa006401.29804512
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29702991
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26943085
57Biosynthesis of amino acids_Homo sapiens_hsa012301.24539980
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21025407
59Fatty acid elongation_Homo sapiens_hsa000621.20324190
60TNF signaling pathway_Homo sapiens_hsa046681.17544302
61Sulfur metabolism_Homo sapiens_hsa009201.16699176
62Lysine degradation_Homo sapiens_hsa003101.11727751
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11156096
64Steroid biosynthesis_Homo sapiens_hsa001001.10515224
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.09807846
66Arginine and proline metabolism_Homo sapiens_hsa003301.07948138
67mTOR signaling pathway_Homo sapiens_hsa041501.07542468
68Renal cell carcinoma_Homo sapiens_hsa052111.05493030
69ErbB signaling pathway_Homo sapiens_hsa040121.04794473
70Fatty acid biosynthesis_Homo sapiens_hsa000611.03123236
71Lysosome_Homo sapiens_hsa041421.02293018
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01394128
73Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00729715
74Influenza A_Homo sapiens_hsa051641.00601631
75Tuberculosis_Homo sapiens_hsa051521.00424229
76Vitamin digestion and absorption_Homo sapiens_hsa049770.97809086
77Endocytosis_Homo sapiens_hsa041440.97167983
78GnRH signaling pathway_Homo sapiens_hsa049120.96349983
79Carbon metabolism_Homo sapiens_hsa012000.95811582
80Pyruvate metabolism_Homo sapiens_hsa006200.95443967
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95420293
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.94307357
83Shigellosis_Homo sapiens_hsa051310.94172971
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.93885664
85Endometrial cancer_Homo sapiens_hsa052130.92882146
86Inositol phosphate metabolism_Homo sapiens_hsa005620.92333097
87Salmonella infection_Homo sapiens_hsa051320.90062578
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89506052
89Hepatitis B_Homo sapiens_hsa051610.88195111
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88133280
91Choline metabolism in cancer_Homo sapiens_hsa052310.87612208
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87267026
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87226210
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84409909
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.83282650
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83054833
97Glutathione metabolism_Homo sapiens_hsa004800.80999275
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75744596
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74264038
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74045743
101T cell receptor signaling pathway_Homo sapiens_hsa046600.72645097
102Glycerolipid metabolism_Homo sapiens_hsa005610.71381001
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68631833
104Platelet activation_Homo sapiens_hsa046110.68539715
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67126203
106Pentose phosphate pathway_Homo sapiens_hsa000300.67008834
107Prolactin signaling pathway_Homo sapiens_hsa049170.66922207
108Renin-angiotensin system_Homo sapiens_hsa046140.66858309
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.66611970
110Estrogen signaling pathway_Homo sapiens_hsa049150.66555485
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65656882
112Viral carcinogenesis_Homo sapiens_hsa052030.65537820
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62749997
114Focal adhesion_Homo sapiens_hsa045100.62628764
115Bladder cancer_Homo sapiens_hsa052190.62521657
116Axon guidance_Homo sapiens_hsa043600.61769707
117N-Glycan biosynthesis_Homo sapiens_hsa005100.60892782
118Measles_Homo sapiens_hsa051620.59785984
119Herpes simplex infection_Homo sapiens_hsa051680.59321823
120Proteoglycans in cancer_Homo sapiens_hsa052050.57462378
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56923851
122Malaria_Homo sapiens_hsa051440.55936175
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.55038767
124HTLV-I infection_Homo sapiens_hsa051660.54242316
125Glioma_Homo sapiens_hsa052140.52099267
126Chemokine signaling pathway_Homo sapiens_hsa040620.52085822
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51732513
128Base excision repair_Homo sapiens_hsa034100.51239361
129Galactose metabolism_Homo sapiens_hsa000520.50958816
130Insulin resistance_Homo sapiens_hsa049310.50519359
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48722994
132Pertussis_Homo sapiens_hsa051330.47961693
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.47768699
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46976750
135MicroRNAs in cancer_Homo sapiens_hsa052060.45765858
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45206157
137African trypanosomiasis_Homo sapiens_hsa051430.45095519
138Systemic lupus erythematosus_Homo sapiens_hsa053220.42993487
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40689022
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37709259
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35565049
142Vitamin B6 metabolism_Homo sapiens_hsa007500.34464120
143Fructose and mannose metabolism_Homo sapiens_hsa000510.33646904
144Metabolic pathways_Homo sapiens_hsa011000.29953478
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.29876536
146Linoleic acid metabolism_Homo sapiens_hsa005910.26878774
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22986201
148Prion diseases_Homo sapiens_hsa050200.20764494
149Sphingolipid metabolism_Homo sapiens_hsa006000.17540979
150Amoebiasis_Homo sapiens_hsa051460.16224663
151AMPK signaling pathway_Homo sapiens_hsa041520.15666215
152Thyroid cancer_Homo sapiens_hsa052160.14142282
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.12019483
154Glucagon signaling pathway_Homo sapiens_hsa049220.10261150
155Apoptosis_Homo sapiens_hsa042100.09907727
156Hepatitis C_Homo sapiens_hsa051600.09852589
157Arachidonic acid metabolism_Homo sapiens_hsa005900.07594988
158Other glycan degradation_Homo sapiens_hsa005110.07097576
159Insulin signaling pathway_Homo sapiens_hsa049100.06871511
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05087883
161Legionellosis_Homo sapiens_hsa051340.04737761
162Chronic myeloid leukemia_Homo sapiens_hsa052200.01327068
163Small cell lung cancer_Homo sapiens_hsa052220.00820500
164Mineral absorption_Homo sapiens_hsa04978-0.0178159
165p53 signaling pathway_Homo sapiens_hsa04115-0.0173841
166Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0156149
167Toxoplasmosis_Homo sapiens_hsa05145-0.0132898
168Acute myeloid leukemia_Homo sapiens_hsa05221-0.0050677

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