MROH7-TTC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring MROH7 (maestro heat-like repeat family member 7) and TTC4 (tetratricopeptide repeat domain 4) genes. Alternative splicing results in multiple transcript variants, which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce protein products. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.44329590
2acrosome reaction (GO:0007340)5.39806408
3cellular ketone body metabolic process (GO:0046950)4.94876632
4axonemal dynein complex assembly (GO:0070286)4.87403311
5response to pheromone (GO:0019236)4.70832201
6regulation of cilium movement (GO:0003352)4.68818885
7protein polyglutamylation (GO:0018095)4.61745550
8cilium or flagellum-dependent cell motility (GO:0001539)4.49359986
9ketone body metabolic process (GO:1902224)4.33316321
10epithelial cilium movement (GO:0003351)4.30145658
11axoneme assembly (GO:0035082)4.27894880
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26553211
13fusion of sperm to egg plasma membrane (GO:0007342)4.11808784
14single strand break repair (GO:0000012)4.10210650
15cilium movement (GO:0003341)4.03541720
16multicellular organism reproduction (GO:0032504)3.85831904
17motile cilium assembly (GO:0044458)3.79052712
18calcium ion-dependent exocytosis (GO:0017156)3.70306782
19behavioral response to nicotine (GO:0035095)3.68572802
20regulation of microtubule-based movement (GO:0060632)3.53677155
21spermatid development (GO:0007286)3.43534467
22positive regulation of glycolytic process (GO:0045821)3.36055784
23rRNA methylation (GO:0031167)3.34632077
24regulation of relaxation of muscle (GO:1901077)3.34219864
25plasma membrane fusion (GO:0045026)3.34113703
26organic cation transport (GO:0015695)3.31764241
27actin-myosin filament sliding (GO:0033275)3.29927016
28muscle filament sliding (GO:0030049)3.29927016
29piRNA metabolic process (GO:0034587)3.26236014
30establishment of protein localization to Golgi (GO:0072600)3.23930069
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22630308
32protein targeting to Golgi (GO:0000042)3.20684641
33sperm capacitation (GO:0048240)3.18700145
34fucose catabolic process (GO:0019317)3.18346094
35L-fucose metabolic process (GO:0042354)3.18346094
36L-fucose catabolic process (GO:0042355)3.18346094
37sperm-egg recognition (GO:0035036)3.18075211
38rRNA modification (GO:0000154)3.05665777
39nephron tubule morphogenesis (GO:0072078)3.05009906
40nephron epithelium morphogenesis (GO:0072088)3.05009906
41indole-containing compound catabolic process (GO:0042436)3.04048156
42indolalkylamine catabolic process (GO:0046218)3.04048156
43tryptophan catabolic process (GO:0006569)3.04048156
44neuronal action potential (GO:0019228)2.98929562
45DNA methylation involved in gamete generation (GO:0043046)2.95725251
46reproduction (GO:0000003)2.93413334
47gamma-aminobutyric acid transport (GO:0015812)2.93388144
48kynurenine metabolic process (GO:0070189)2.93326943
49microtubule severing (GO:0051013)2.90373914
50water-soluble vitamin biosynthetic process (GO:0042364)2.89583906
51retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87602590
52NAD biosynthetic process (GO:0009435)2.86760333
53negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86007209
54cilium organization (GO:0044782)2.81897957
55regulation of skeletal muscle contraction (GO:0014819)2.81844109
56RNA destabilization (GO:0050779)2.80994581
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78358004
58membrane depolarization during action potential (GO:0086010)2.77293861
59regulation of cell communication by electrical coupling (GO:0010649)2.73446746
60cell-cell recognition (GO:0009988)2.72890179
61protein localization to Golgi apparatus (GO:0034067)2.71993090
62cilium assembly (GO:0042384)2.70940010
63male meiosis (GO:0007140)2.68682853
64protein-cofactor linkage (GO:0018065)2.67937392
65cAMP catabolic process (GO:0006198)2.67530792
66C4-dicarboxylate transport (GO:0015740)2.65617167
67alanine transport (GO:0032328)2.63619525
68positive regulation of mitochondrial fission (GO:0090141)2.61068958
69regulation of action potential (GO:0098900)2.59525881
70actin-mediated cell contraction (GO:0070252)2.58250357
71spinal cord motor neuron differentiation (GO:0021522)2.57765961
72negative regulation of Rho protein signal transduction (GO:0035024)2.57683761
73primary amino compound metabolic process (GO:1901160)2.57174235
74DNA deamination (GO:0045006)2.51722184
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.51476614
76coenzyme catabolic process (GO:0009109)2.51084880
77neuronal action potential propagation (GO:0019227)2.49251375
78regulation of glucokinase activity (GO:0033131)2.49196428
79regulation of hexokinase activity (GO:1903299)2.49196428
80phosphatidylethanolamine biosynthetic process (GO:0006646)2.48979024
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.47722037
82NADH dehydrogenase complex assembly (GO:0010257)2.47722037
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47722037
84proline transport (GO:0015824)2.46950927
85cellular component assembly involved in morphogenesis (GO:0010927)2.46536746
86regulation of membrane repolarization (GO:0060306)2.46517805
87spermatogenesis (GO:0007283)2.46361843
88action potential (GO:0001508)2.46001949
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45710105
90male gamete generation (GO:0048232)2.45574946
91myofibril assembly (GO:0030239)2.45444522
92striated muscle contraction (GO:0006941)2.45085838
93dopamine transport (GO:0015872)2.42292996
94single fertilization (GO:0007338)2.41707286
95protein complex biogenesis (GO:0070271)2.40687656
96indolalkylamine metabolic process (GO:0006586)2.40458755
97detection of light stimulus involved in visual perception (GO:0050908)2.38288107
98detection of light stimulus involved in sensory perception (GO:0050962)2.38288107
99negative regulation of heart rate (GO:0010459)2.36841010
100S-adenosylmethionine metabolic process (GO:0046500)2.35217520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06135210
2VDR_22108803_ChIP-Seq_LS180_Human2.99291207
3ZNF274_21170338_ChIP-Seq_K562_Hela2.99276794
4EZH2_22144423_ChIP-Seq_EOC_Human2.97297802
5GBX2_23144817_ChIP-Seq_PC3_Human2.33321758
6IGF1R_20145208_ChIP-Seq_DFB_Human2.19331524
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.12167324
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10454588
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08887041
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03624350
11CBP_20019798_ChIP-Seq_JUKART_Human1.87876989
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87876989
13FUS_26573619_Chip-Seq_HEK293_Human1.87391671
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80410333
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79917915
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79748300
17ER_23166858_ChIP-Seq_MCF-7_Human1.74176920
18P300_19829295_ChIP-Seq_ESCs_Human1.71074142
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66618578
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65347106
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58489099
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56845865
23SOX2_19829295_ChIP-Seq_ESCs_Human1.55521831
24NANOG_19829295_ChIP-Seq_ESCs_Human1.55521831
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49986317
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48997892
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48098538
28DROSHA_22980978_ChIP-Seq_HELA_Human1.44921981
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44156043
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39910276
31OCT4_20526341_ChIP-Seq_ESCs_Human1.38019311
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37286703
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37286703
34REST_21632747_ChIP-Seq_MESCs_Mouse1.36045618
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.34197662
36SMAD4_21799915_ChIP-Seq_A2780_Human1.33339492
37TCF4_23295773_ChIP-Seq_U87_Human1.32984608
38MYC_19829295_ChIP-Seq_ESCs_Human1.31400397
39BCAT_22108803_ChIP-Seq_LS180_Human1.31022836
40STAT3_23295773_ChIP-Seq_U87_Human1.30865077
41TAF15_26573619_Chip-Seq_HEK293_Human1.30540049
42AR_25329375_ChIP-Seq_VCAP_Human1.30391407
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.30219621
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.30013086
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29504992
46NANOG_20526341_ChIP-Seq_ESCs_Human1.28894410
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27934878
48TP53_22573176_ChIP-Seq_HFKS_Human1.26314204
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23967769
50TAF2_19829295_ChIP-Seq_ESCs_Human1.23660855
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23208412
52ERA_21632823_ChIP-Seq_H3396_Human1.22389944
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21801302
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21274562
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20592938
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19966503
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.19056950
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19056950
59NCOR_22424771_ChIP-Seq_293T_Human1.18051043
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.17753694
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16865453
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14726918
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12932398
64CDX2_22108803_ChIP-Seq_LS180_Human1.12869412
65RUNX2_22187159_ChIP-Seq_PCA_Human1.12438548
66TCF4_22108803_ChIP-Seq_LS180_Human1.11978177
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.11685331
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.11678341
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10126429
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09474876
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.09332335
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.09070155
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.08773975
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07797917
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07495230
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07484916
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07482216
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07480632
79EWS_26573619_Chip-Seq_HEK293_Human1.07114361
80RAC3_21632823_ChIP-Seq_H3396_Human1.07030175
81HOXB7_26014856_ChIP-Seq_BT474_Human1.04506544
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04482549
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.04265158
84AR_20517297_ChIP-Seq_VCAP_Human1.04103810
85TBL1_22424771_ChIP-Seq_293T_Human1.03675186
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03044383
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.02991542
88ETV1_20927104_ChIP-Seq_GIST48_Human1.01420976
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01400794
90PHF8_20622853_ChIP-Seq_HELA_Human1.01164545
91RBPJ_21746931_ChIP-Seq_IB4_Human1.00528107
92FOXH1_21741376_ChIP-Seq_ESCs_Human1.00148512
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.97632331
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97414536
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.97371583
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96284207
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95863911
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95699646
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95243405
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.95230087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.47641204
2MP0003646_muscle_fatigue4.00360222
3MP0005410_abnormal_fertilization3.98602552
4MP0008877_abnormal_DNA_methylation2.89390735
5MP0004084_abnormal_cardiac_muscle2.29333561
6MP0004215_abnormal_myocardial_fiber2.26573413
7MP0003195_calcinosis2.24472664
8MP0005670_abnormal_white_adipose2.21058409
9MP0004145_abnormal_muscle_electrophysio2.19276231
10MP0004036_abnormal_muscle_relaxation2.12348642
11MP0002138_abnormal_hepatobiliary_system2.01963597
12MP0003137_abnormal_impulse_conducting1.97728433
13MP0005646_abnormal_pituitary_gland1.97302385
14MP0005377_hearing/vestibular/ear_phenot1.96725577
15MP0003878_abnormal_ear_physiology1.96725577
16MP0005551_abnormal_eye_electrophysiolog1.89164836
17MP0003787_abnormal_imprinting1.81432022
18MP0008775_abnormal_heart_ventricle1.78558846
19MP0004885_abnormal_endolymph1.76764775
20MP0001968_abnormal_touch/_nociception1.72949271
21MP0002272_abnormal_nervous_system1.71903515
22MP0001486_abnormal_startle_reflex1.70751698
23MP0002102_abnormal_ear_morphology1.68999306
24MP0003880_abnormal_central_pattern1.68797808
25MP0000749_muscle_degeneration1.67420742
26MP0006276_abnormal_autonomic_nervous1.64183927
27MP0002876_abnormal_thyroid_physiology1.64120935
28MP0009745_abnormal_behavioral_response1.63252750
29MP0009046_muscle_twitch1.62537911
30MP0003698_abnormal_male_reproductive1.61457214
31MP0004147_increased_porphyrin_level1.49992613
32MP0004142_abnormal_muscle_tone1.47361152
33MP0001501_abnormal_sleep_pattern1.45259105
34MP0001984_abnormal_olfaction1.44011184
35MP0004484_altered_response_of1.43575500
36MP0005253_abnormal_eye_physiology1.42798522
37MP0005620_abnormal_muscle_contractility1.40722266
38MP0004043_abnormal_pH_regulation1.38914882
39MP0008875_abnormal_xenobiotic_pharmacok1.38678246
40MP0001485_abnormal_pinna_reflex1.37707361
41MP0006036_abnormal_mitochondrial_physio1.37204392
42MP0004085_abnormal_heartbeat1.35838369
43MP0000569_abnormal_digit_pigmentation1.34482773
44MP0005084_abnormal_gallbladder_morpholo1.31333581
45MP0005167_abnormal_blood-brain_barrier1.30779795
46MP0001929_abnormal_gametogenesis1.28679423
47MP0000751_myopathy1.27652735
48MP0008872_abnormal_physiological_respon1.27468462
49MP0001986_abnormal_taste_sensitivity1.25510093
50MP0000013_abnormal_adipose_tissue1.22317137
51MP0006072_abnormal_retinal_apoptosis1.20008103
52MP0001905_abnormal_dopamine_level1.19911057
53MP0004130_abnormal_muscle_cell1.18540689
54MP0002064_seizures1.18191389
55MP0002733_abnormal_thermal_nociception1.18141773
56MP0002972_abnormal_cardiac_muscle1.18071605
57MP0002735_abnormal_chemical_nociception1.17328029
58MP0002572_abnormal_emotion/affect_behav1.16920902
59MP0001970_abnormal_pain_threshold1.11756258
60MP0002638_abnormal_pupillary_reflex1.11293125
61MP0003879_abnormal_hair_cell1.09720864
62MP0000230_abnormal_systemic_arterial1.06728135
63MP0001502_abnormal_circadian_rhythm1.05874706
64MP0008995_early_reproductive_senescence1.05004055
65MP0002127_abnormal_cardiovascular_syste1.02893953
66MP0005332_abnormal_amino_acid1.02273136
67MP0003635_abnormal_synaptic_transmissio1.02263691
68MP0002229_neurodegeneration1.02158913
69MP0005330_cardiomyopathy1.01916949
70MP0002557_abnormal_social/conspecific_i0.97961126
71MP0002063_abnormal_learning/memory/cond0.97873508
72MP0002106_abnormal_muscle_physiology0.97686735
73MP0002736_abnormal_nociception_after0.97207511
74MP0001963_abnormal_hearing_physiology0.97122026
75MP0001764_abnormal_homeostasis0.95490625
76MP0000372_irregular_coat_pigmentation0.94362973
77MP0005386_behavior/neurological_phenoty0.93769427
78MP0004924_abnormal_behavior0.93769427
79MP0002067_abnormal_sensory_capabilities0.92934899
80MP0002734_abnormal_mechanical_nocicepti0.92919703
81MP0000026_abnormal_inner_ear0.91893211
82MP0004133_heterotaxia0.91818633
83MP0005645_abnormal_hypothalamus_physiol0.90752217
84MP0003136_yellow_coat_color0.89275155
85MP0001440_abnormal_grooming_behavior0.86298644
86MP0003011_delayed_dark_adaptation0.84549515
87MP0001765_abnormal_ion_homeostasis0.84467455
88MP0005369_muscle_phenotype0.83674932
89MP0005174_abnormal_tail_pigmentation0.82848065
90MP0002693_abnormal_pancreas_physiology0.79339594
91MP0005535_abnormal_body_temperature0.79237577
92MP0002653_abnormal_ependyma_morphology0.78749921
93MP0005379_endocrine/exocrine_gland_phen0.77979145
94MP0002234_abnormal_pharynx_morphology0.77078720
95MP0004270_analgesia0.76543183
96MP0006292_abnormal_olfactory_placode0.75525632
97MP0001544_abnormal_cardiovascular_syste0.74030963
98MP0005385_cardiovascular_system_phenoty0.74030963
99MP0002332_abnormal_exercise_endurance0.73828329
100MP0005636_abnormal_mineral_homeostasis0.71566092

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)4.08936759
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.08936759
3Abnormal respiratory motile cilium morphology (HP:0005938)3.75170917
4Abnormal respiratory epithelium morphology (HP:0012253)3.75170917
5Nephronophthisis (HP:0000090)3.58687915
6Chronic hepatic failure (HP:0100626)3.44102180
7Abnormal rod and cone electroretinograms (HP:0008323)3.33746024
8Abnormal ciliary motility (HP:0012262)3.30048659
9Pancreatic cysts (HP:0001737)3.29342761
10Attenuation of retinal blood vessels (HP:0007843)3.27640334
11Muscle hypertrophy of the lower extremities (HP:0008968)3.27479281
12Pancreatic fibrosis (HP:0100732)3.20168622
13Abnormal respiratory motile cilium physiology (HP:0012261)3.08613405
14Polydipsia (HP:0001959)3.06441170
15Abnormal drinking behavior (HP:0030082)3.06441170
16Molar tooth sign on MRI (HP:0002419)3.01688889
17Abnormality of midbrain morphology (HP:0002418)3.01688889
18Calf muscle hypertrophy (HP:0008981)3.01549783
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.00682598
20True hermaphroditism (HP:0010459)2.95855932
21Abnormality of the renal medulla (HP:0100957)2.95651361
22Severe visual impairment (HP:0001141)2.93703525
23Abnormality of the renal cortex (HP:0011035)2.90680951
24Tubulointerstitial nephritis (HP:0001970)2.82847904
25Tubular atrophy (HP:0000092)2.79300108
26Type II lissencephaly (HP:0007260)2.69333615
27Muscle fiber inclusion bodies (HP:0100299)2.68583178
28Hyperkalemia (HP:0002153)2.61662669
29Congenital stationary night blindness (HP:0007642)2.61201594
30Nemaline bodies (HP:0003798)2.55083360
31Decreased circulating renin level (HP:0003351)2.52823874
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.52703567
33Sudden death (HP:0001699)2.51817859
34Abnormality of alanine metabolism (HP:0010916)2.49580168
35Hyperalaninemia (HP:0003348)2.49580168
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49580168
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48068084
38Pendular nystagmus (HP:0012043)2.40788872
39Polyuria (HP:0000103)2.39049858
40Atrial fibrillation (HP:0005110)2.38071078
41Bony spicule pigmentary retinopathy (HP:0007737)2.35449348
42Congenital sensorineural hearing impairment (HP:0008527)2.33791656
43Progressive cerebellar ataxia (HP:0002073)2.33566721
44Asymmetric septal hypertrophy (HP:0001670)2.33388727
45Decreased central vision (HP:0007663)2.32808308
46Medial flaring of the eyebrow (HP:0010747)2.30798399
47Abnormal urine output (HP:0012590)2.29161769
48Abolished electroretinogram (ERG) (HP:0000550)2.28928552
49Syncope (HP:0001279)2.25549702
50Bundle branch block (HP:0011710)2.24851812
51Primary atrial arrhythmia (HP:0001692)2.23078405
52Congenital hepatic fibrosis (HP:0002612)2.23054149
53Cerebellar dysplasia (HP:0007033)2.19154400
54Mitochondrial inheritance (HP:0001427)2.16807156
55Supraventricular tachycardia (HP:0004755)2.14402447
56Abnormality of urine glucose concentration (HP:0011016)2.13103819
57Glycosuria (HP:0003076)2.13103819
58Constricted visual fields (HP:0001133)2.12377105
59Rhinitis (HP:0012384)2.10225204
60Abnormality of renal excretion (HP:0011036)2.08128253
61Generalized aminoaciduria (HP:0002909)2.05528658
62Supraventricular arrhythmia (HP:0005115)2.03989854
63Exercise-induced muscle cramps (HP:0003710)2.03616244
64Cystic liver disease (HP:0006706)2.03597647
65Insulin-resistant diabetes mellitus (HP:0000831)1.99305843
66Increased CSF lactate (HP:0002490)1.96849472
67Abnormality of potassium homeostasis (HP:0011042)1.96045870
68Renal cortical cysts (HP:0000803)1.95888061
69Acute necrotizing encephalopathy (HP:0006965)1.95611319
70Ventricular tachycardia (HP:0004756)1.93416837
71Prolonged QT interval (HP:0001657)1.92366773
72Hepatic necrosis (HP:0002605)1.91988261
73Occipital encephalocele (HP:0002085)1.91482886
74Ketosis (HP:0001946)1.91354880
75Optic disc pallor (HP:0000543)1.91000577
76Type 2 muscle fiber atrophy (HP:0003554)1.90319694
77Abnormality of the calf musculature (HP:0001430)1.90144217
78Keratoconus (HP:0000563)1.89241809
79Increased corneal curvature (HP:0100692)1.89241809
80Left ventricular hypertrophy (HP:0001712)1.88549393
81Muscle fiber splitting (HP:0003555)1.86608363
82Facial shape deformation (HP:0011334)1.86503350
83Potter facies (HP:0002009)1.86503350
84Abnormal EKG (HP:0003115)1.86044915
85Tubulointerstitial abnormality (HP:0001969)1.85985496
86Heart block (HP:0012722)1.85026897
87Ketoacidosis (HP:0001993)1.84832882
88Large for gestational age (HP:0001520)1.83617046
89Acute encephalopathy (HP:0006846)1.82806201
90Progressive macrocephaly (HP:0004481)1.80340174
91Renal Fanconi syndrome (HP:0001994)1.80132706
92Abnormality of renin-angiotensin system (HP:0000847)1.79914918
93Double outlet right ventricle (HP:0001719)1.78112561
94Congenital malformation of the right heart (HP:0011723)1.78112561
95Hepatocellular necrosis (HP:0001404)1.77936813
96Type 1 muscle fiber predominance (HP:0003803)1.77927485
97Hypokalemia (HP:0002900)1.76516503
98Inability to walk (HP:0002540)1.75707116
99Aplasia/hypoplasia of the uterus (HP:0008684)1.74150544
100Chronic bronchitis (HP:0004469)1.74079745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.19039426
2OBSCN3.63462697
3PINK13.32442657
4MAP4K23.06238595
5PHKG13.05549518
6PHKG23.05549518
7ADRBK22.61049511
8INSRR2.28219494
9WNK32.23181802
10GRK12.22585197
11DAPK22.11424786
12MARK12.04474527
13MAPK152.00409334
14WNK41.86867513
15TIE11.82419563
16MAP3K91.69385181
17TLK11.66757471
18PLK41.58465522
19PLK21.45234566
20MUSK1.44734619
21ACVR1B1.40150596
22NUAK11.39503038
23PIK3CG1.34035295
24NTRK31.32216756
25MAP3K41.24893268
26STK391.23900218
27BMPR1B1.22273010
28BCKDK1.21203451
29MAPK131.18116200
30NTRK21.18103287
31TXK1.17403541
32PIK3CA1.13507435
33OXSR11.11037746
34NME11.09897047
35ZAK1.07018317
36MAP2K61.02316904
37MAPKAPK30.97954678
38GRK70.97193762
39PTK2B0.94283898
40TNIK0.94032905
41STK38L0.92515642
42CASK0.90197947
43PRKCE0.86092826
44CAMK10.85484279
45PKN10.84701961
46PAK30.84088102
47PRKCQ0.83900832
48EPHA40.77047500
49MAP2K70.76221031
50CAMK2A0.74696050
51IKBKB0.72192042
52MAP3K110.71178451
53CAMK2D0.69988782
54SGK4940.69517611
55SGK2230.69517611
56PRKCG0.68898618
57KIT0.67213101
58DDR20.66094453
59FGFR20.65070618
60TAOK30.64198258
61PNCK0.63218122
62PRKACA0.63161318
63PRKAA20.63039584
64ADRBK10.61811203
65RPS6KA50.60946149
66MARK30.60102372
67PRKG10.58980061
68MYLK0.57553987
69PDK20.57377434
70SGK20.56846657
71FLT30.54992281
72DYRK20.53407499
73PDK10.53335809
74TNK20.50804583
75WNK10.49449521
76TTN0.48847961
77MAP2K40.47979195
78ROCK10.47306515
79FER0.47300590
80PRKAA10.45850322
81TESK10.41916801
82MAP3K70.41368492
83IKBKE0.40331784
84RPS6KA10.39909717
85PDPK10.39703595
86MKNK20.39671611
87PRKCA0.39273996
88CAMK2G0.38971222
89SGK10.38630097
90RPS6KA60.38568625
91CSNK1A10.36626976
92TEC0.35737148
93EIF2AK30.35430999
94STK380.34686581
95ITK0.33130321
96SYK0.32618067
97MAP2K10.31398543
98PRKACB0.30867594
99CSNK1G20.30449449
100MATK0.30097938

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49399755
2Butanoate metabolism_Homo sapiens_hsa006502.73919614
3Cardiac muscle contraction_Homo sapiens_hsa042602.51504455
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.39055999
5Nitrogen metabolism_Homo sapiens_hsa009102.35921801
6Oxidative phosphorylation_Homo sapiens_hsa001902.34655336
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21228190
8Linoleic acid metabolism_Homo sapiens_hsa005912.09953922
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95735397
10Phototransduction_Homo sapiens_hsa047441.86897998
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83912837
12Nicotine addiction_Homo sapiens_hsa050331.82143801
13Parkinsons disease_Homo sapiens_hsa050121.74449036
14Propanoate metabolism_Homo sapiens_hsa006401.70002076
15Tryptophan metabolism_Homo sapiens_hsa003801.69794418
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60425131
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59628112
18Morphine addiction_Homo sapiens_hsa050321.48874745
19Asthma_Homo sapiens_hsa053101.47481044
20Type I diabetes mellitus_Homo sapiens_hsa049401.46827445
21Taste transduction_Homo sapiens_hsa047421.45747411
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41632364
23Collecting duct acid secretion_Homo sapiens_hsa049661.40478577
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39981818
25Fatty acid biosynthesis_Homo sapiens_hsa000611.39465529
26Insulin secretion_Homo sapiens_hsa049111.38908866
27Olfactory transduction_Homo sapiens_hsa047401.37613415
28Selenocompound metabolism_Homo sapiens_hsa004501.36821710
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33472455
30Ether lipid metabolism_Homo sapiens_hsa005651.32281242
31Fatty acid degradation_Homo sapiens_hsa000711.30546139
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.29190204
33Calcium signaling pathway_Homo sapiens_hsa040201.27296296
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26760598
35Sulfur relay system_Homo sapiens_hsa041221.20431363
36Circadian rhythm_Homo sapiens_hsa047101.20378758
37Huntingtons disease_Homo sapiens_hsa050161.20222248
38Alzheimers disease_Homo sapiens_hsa050101.19090724
39GABAergic synapse_Homo sapiens_hsa047271.15192170
40Peroxisome_Homo sapiens_hsa041461.14136643
41Circadian entrainment_Homo sapiens_hsa047131.13231085
42Arginine biosynthesis_Homo sapiens_hsa002201.12730213
43Allograft rejection_Homo sapiens_hsa053301.11241586
44ABC transporters_Homo sapiens_hsa020101.04309924
45Salivary secretion_Homo sapiens_hsa049701.01199734
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00800972
47Caffeine metabolism_Homo sapiens_hsa002321.00790531
48Basal transcription factors_Homo sapiens_hsa030220.99521740
49beta-Alanine metabolism_Homo sapiens_hsa004100.98210627
50Dilated cardiomyopathy_Homo sapiens_hsa054140.98064450
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95461865
52Regulation of autophagy_Homo sapiens_hsa041400.95105150
53Renin secretion_Homo sapiens_hsa049240.94558888
54Fatty acid metabolism_Homo sapiens_hsa012120.94350041
55Autoimmune thyroid disease_Homo sapiens_hsa053200.93656224
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92501538
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91369474
58Arginine and proline metabolism_Homo sapiens_hsa003300.91077419
59Chemical carcinogenesis_Homo sapiens_hsa052040.89775805
60Serotonergic synapse_Homo sapiens_hsa047260.89751449
61Synaptic vesicle cycle_Homo sapiens_hsa047210.87933657
62Graft-versus-host disease_Homo sapiens_hsa053320.87174276
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85336255
64Glutamatergic synapse_Homo sapiens_hsa047240.83202088
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82970351
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78229382
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77187883
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75882703
69Arachidonic acid metabolism_Homo sapiens_hsa005900.73072321
70Rheumatoid arthritis_Homo sapiens_hsa053230.72333595
71Dorso-ventral axis formation_Homo sapiens_hsa043200.69882619
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69539407
73Purine metabolism_Homo sapiens_hsa002300.68782657
74RNA polymerase_Homo sapiens_hsa030200.68233813
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.64608405
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64185236
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.62422130
78Histidine metabolism_Homo sapiens_hsa003400.61002016
79One carbon pool by folate_Homo sapiens_hsa006700.60528748
80Sulfur metabolism_Homo sapiens_hsa009200.60406680
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60067439
82Oxytocin signaling pathway_Homo sapiens_hsa049210.59670083
83RNA degradation_Homo sapiens_hsa030180.58406816
84cAMP signaling pathway_Homo sapiens_hsa040240.57281566
85Metabolic pathways_Homo sapiens_hsa011000.56952338
86Retinol metabolism_Homo sapiens_hsa008300.56914836
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56619451
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.55839591
89PPAR signaling pathway_Homo sapiens_hsa033200.55239545
90Fat digestion and absorption_Homo sapiens_hsa049750.53614320
91Ovarian steroidogenesis_Homo sapiens_hsa049130.53276575
92Glycerolipid metabolism_Homo sapiens_hsa005610.50467454
93Type II diabetes mellitus_Homo sapiens_hsa049300.48473953
94Mineral absorption_Homo sapiens_hsa049780.45434396
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.44796537
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43629883
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42906368
98Dopaminergic synapse_Homo sapiens_hsa047280.42670273
99Amphetamine addiction_Homo sapiens_hsa050310.42414910
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40535598

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