MROH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.98209953
2plasma membrane fusion (GO:0045026)9.86953342
3motile cilium assembly (GO:0044458)9.59994030
4spermatid development (GO:0007286)9.29173016
5reproduction (GO:0000003)9.10920944
6male meiosis (GO:0007140)8.85901598
7cilium movement (GO:0003341)8.69328747
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.55080807
9regulation of cilium movement (GO:0003352)8.29078393
10synaptonemal complex organization (GO:0070193)8.16729174
11synaptonemal complex assembly (GO:0007130)7.91539050
12single fertilization (GO:0007338)7.37604483
13sperm capacitation (GO:0048240)7.23761137
14DNA methylation involved in gamete generation (GO:0043046)6.44708567
15negative regulation of inclusion body assembly (GO:0090084)6.43381812
16fertilization (GO:0009566)6.32317298
17spermatogenesis (GO:0007283)6.03802313
18male gamete generation (GO:0048232)6.01667773
19male meiosis I (GO:0007141)6.00543600
20chromosome organization involved in meiosis (GO:0070192)5.58423769
21gamete generation (GO:0007276)5.53604669
22ventricular system development (GO:0021591)5.48543362
23microtubule depolymerization (GO:0007019)5.44627168
24germ cell development (GO:0007281)5.34920157
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.32578438
26organic cation transport (GO:0015695)5.27519956
27regulation of inclusion body assembly (GO:0090083)5.22633388
28meiotic nuclear division (GO:0007126)5.19599574
29cell recognition (GO:0008037)4.93814573
30meiosis I (GO:0007127)4.92779944
31regulation of microtubule-based movement (GO:0060632)4.91518962
32calcium ion-dependent exocytosis (GO:0017156)4.87112435
33microtubule severing (GO:0051013)4.79002976
34seminiferous tubule development (GO:0072520)4.77855343
35pyrimidine nucleobase catabolic process (GO:0006208)4.65461783
36spermatid nucleus differentiation (GO:0007289)4.57952640
37meiotic cell cycle (GO:0051321)4.42779661
38multicellular organismal reproductive process (GO:0048609)4.32178260
39left/right pattern formation (GO:0060972)4.27065637
40protein localization to cilium (GO:0061512)4.25098569
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18324527
42mitochondrial respiratory chain complex I assembly (GO:0032981)4.18324527
43NADH dehydrogenase complex assembly (GO:0010257)4.18324527
44behavioral response to nicotine (GO:0035095)4.14629828
45protein complex biogenesis (GO:0070271)4.09140950
46genitalia morphogenesis (GO:0035112)4.05350284
47monoubiquitinated protein deubiquitination (GO:0035520)3.95793069
48gene silencing by RNA (GO:0031047)3.86860446
49protein polyglutamylation (GO:0018095)3.81783522
50intraciliary transport (GO:0042073)3.80652391
51mitochondrial respiratory chain complex assembly (GO:0033108)3.79210542
52chaperone-mediated protein complex assembly (GO:0051131)3.73201929
53nucleobase catabolic process (GO:0046113)3.72593155
54multicellular organismal development (GO:0007275)3.51794660
55protein-cofactor linkage (GO:0018065)3.41610103
56positive regulation of mitochondrial fission (GO:0090141)3.41135829
57chromosome condensation (GO:0030261)3.40966051
58synapsis (GO:0007129)3.39951591
59DNA packaging (GO:0006323)3.35789901
60adult feeding behavior (GO:0008343)3.35274776
61meiotic cell cycle process (GO:1903046)3.35153481
62axoneme assembly (GO:0035082)3.33854955
63regulation of spindle checkpoint (GO:0090231)3.33453058
64microtubule-based movement (GO:0007018)3.31737978
65negative regulation of organelle assembly (GO:1902116)3.31050067
66glycerol ether metabolic process (GO:0006662)3.30131225
67platelet dense granule organization (GO:0060155)3.28389248
68regulation of hexokinase activity (GO:1903299)3.28194265
69regulation of glucokinase activity (GO:0033131)3.28194265
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.28117553
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18438302
72cilium organization (GO:0044782)3.16416325
73carnitine transport (GO:0015879)3.13011747
74amino-acid betaine transport (GO:0015838)3.13011747
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12452815
76respiratory chain complex IV assembly (GO:0008535)3.12424461
77carnitine transmembrane transport (GO:1902603)3.10130956
78nonmotile primary cilium assembly (GO:0035058)3.09597462
79limb bud formation (GO:0060174)3.07553606
80somite development (GO:0061053)3.06990310
81regulation of centriole replication (GO:0046599)3.04800135
82ether metabolic process (GO:0018904)3.04465278
83cilium assembly (GO:0042384)3.02520171
84water-soluble vitamin biosynthetic process (GO:0042364)3.02277824
85regulation of meiosis I (GO:0060631)3.00818094
86ubiquinone biosynthetic process (GO:0006744)2.99839425
87cilium morphogenesis (GO:0060271)2.98792756
88nucleoside diphosphate phosphorylation (GO:0006165)2.98129339
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95929567
90presynaptic membrane organization (GO:0097090)2.94626063
91tachykinin receptor signaling pathway (GO:0007217)2.93517208
92negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93481094
93neural tube formation (GO:0001841)2.93152043
94alditol metabolic process (GO:0019400)2.92003305
95cellular component assembly involved in morphogenesis (GO:0010927)2.91489104
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91416898
97protein refolding (GO:0042026)2.87059468
98centriole replication (GO:0007099)2.86494360
99centriole assembly (GO:0098534)2.86054205
100polyol catabolic process (GO:0046174)2.85113016
101gamma-aminobutyric acid transport (GO:0015812)2.84531091
102microtubule polymerization or depolymerization (GO:0031109)2.83780531
103RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82916676
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82916676
105auditory behavior (GO:0031223)2.80819959
106ubiquinone metabolic process (GO:0006743)2.80659340
107nucleus organization (GO:0006997)2.80480069
108GTP biosynthetic process (GO:0006183)2.80290300
109gene silencing (GO:0016458)2.79704936
110single strand break repair (GO:0000012)2.78258727
111protein K11-linked deubiquitination (GO:0035871)2.75924806
112positive regulation of oligodendrocyte differentiation (GO:0048714)2.75660524
113presynaptic membrane assembly (GO:0097105)2.74767625
114protein neddylation (GO:0045116)2.74421038
115cellular ketone body metabolic process (GO:0046950)2.73797877
116behavioral response to ethanol (GO:0048149)2.73373017
117mitotic sister chromatid cohesion (GO:0007064)2.72309485
118retinal ganglion cell axon guidance (GO:0031290)2.71926176
119cytochrome complex assembly (GO:0017004)2.70082323
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69794095
121response to pheromone (GO:0019236)2.69206205
122electron transport chain (GO:0022900)2.66872511
123inner ear receptor stereocilium organization (GO:0060122)2.65585307
124lactate metabolic process (GO:0006089)2.65511292
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64475823
126ATP synthesis coupled proton transport (GO:0015986)2.64475823
127positive regulation of amino acid transport (GO:0051957)2.64324250
128L-fucose catabolic process (GO:0042355)2.63566583
129fucose catabolic process (GO:0019317)2.63566583
130L-fucose metabolic process (GO:0042354)2.63566583
131respiratory electron transport chain (GO:0022904)2.63383836
132protein localization to synapse (GO:0035418)2.63064022
133glycerophospholipid catabolic process (GO:0046475)2.61196644
134chaperone-mediated protein transport (GO:0072321)2.60907951
135protein deneddylation (GO:0000338)2.60203252
136DNA double-strand break processing (GO:0000729)2.59354249
137mechanosensory behavior (GO:0007638)2.58670435
138positive regulation of meiosis (GO:0045836)2.57320085
139negative regulation of appetite (GO:0032099)2.55760399
140negative regulation of response to food (GO:0032096)2.55760399
141interferon-gamma secretion (GO:0072643)2.54855028
142peptidyl-glutamic acid modification (GO:0018200)2.54219483
143glycerol metabolic process (GO:0006071)2.54212152
144postsynaptic membrane organization (GO:0001941)2.54015182
145RNA localization (GO:0006403)2.52240775
146tryptophan catabolic process (GO:0006569)2.49235870
147indole-containing compound catabolic process (GO:0042436)2.49235870
148indolalkylamine catabolic process (GO:0046218)2.49235870
149replication fork processing (GO:0031297)2.48515886
150neuronal action potential (GO:0019228)2.48135935
151UTP biosynthetic process (GO:0006228)2.47269959
152ketone body metabolic process (GO:1902224)2.46987083
153glycolytic process (GO:0006096)2.46548348
154indolalkylamine metabolic process (GO:0006586)2.46443595
155regulation of feeding behavior (GO:0060259)2.46432174
156transmission of nerve impulse (GO:0019226)2.45743275
157preassembly of GPI anchor in ER membrane (GO:0016254)2.45367378
158photoreceptor cell maintenance (GO:0045494)2.45365480
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45356769
160cullin deneddylation (GO:0010388)2.43707408
161nuclear pore complex assembly (GO:0051292)2.43633303
162quinone biosynthetic process (GO:1901663)2.42946342
163regulation of synapse structural plasticity (GO:0051823)2.42424792
164C4-dicarboxylate transport (GO:0015740)2.42229825
165DNA alkylation (GO:0006305)2.41170418
166L-methionine biosynthetic process (GO:0071265)2.38230549
167amino acid salvage (GO:0043102)2.38230549
168cilium or flagellum-dependent cell motility (GO:0001539)14.3973267
169fusion of sperm to egg plasma membrane (GO:0007342)13.0081417
170sperm motility (GO:0030317)12.3758735
171acrosome assembly (GO:0001675)11.2343444
172sperm-egg recognition (GO:0035036)11.2277908
173multicellular organism reproduction (GO:0032504)11.1343943
174axonemal dynein complex assembly (GO:0070286)10.8988849
175acrosome reaction (GO:0007340)10.6387647
176cell wall macromolecule catabolic process (GO:0016998)10.5659987
177cell wall macromolecule metabolic process (GO:0044036)10.5659987
178piRNA metabolic process (GO:0034587)10.2320682
179binding of sperm to zona pellucida (GO:0007339)10.1827989
180cell-cell recognition (GO:0009988)10.0182283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59496083
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66711107
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53921221
4GBX2_23144817_ChIP-Seq_PC3_Human3.11714458
5IGF1R_20145208_ChIP-Seq_DFB_Human2.80671600
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55336621
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47807553
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45014821
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34687147
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32472412
11FUS_26573619_Chip-Seq_HEK293_Human2.23344434
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.22796441
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15478685
14VDR_22108803_ChIP-Seq_LS180_Human2.13996319
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12912054
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.10254585
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09208235
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05970810
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04432980
20EWS_26573619_Chip-Seq_HEK293_Human2.02515846
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.01619167
22ZNF274_21170338_ChIP-Seq_K562_Hela2.00879883
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8614106
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99847341
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.96034232
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94834899
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92501471
28P300_19829295_ChIP-Seq_ESCs_Human1.89355921
29TAF15_26573619_Chip-Seq_HEK293_Human1.72934958
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67533484
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67114545
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67047298
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.65276854
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63177092
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58961172
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57576683
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55919708
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55596279
39STAT1_17558387_ChIP-Seq_HELA_Human1.55484432
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55301400
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54589584
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.53512178
43BCAT_22108803_ChIP-Seq_LS180_Human1.52651587
44IRF1_19129219_ChIP-ChIP_H3396_Human1.52248552
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.51711029
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49872650
47TP53_22573176_ChIP-Seq_HFKS_Human1.49407224
48ER_23166858_ChIP-Seq_MCF-7_Human1.48934838
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.48645992
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47952978
51SMAD4_21799915_ChIP-Seq_A2780_Human1.45407329
52AR_25329375_ChIP-Seq_VCAP_Human1.45172494
53FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45117385
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43805225
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43261508
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41471605
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.40064026
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39134814
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39037381
60CBP_20019798_ChIP-Seq_JUKART_Human1.37198880
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37198880
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37191439
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35188942
64NANOG_19829295_ChIP-Seq_ESCs_Human1.33771719
65SOX2_19829295_ChIP-Seq_ESCs_Human1.33771719
66REST_21632747_ChIP-Seq_MESCs_Mouse1.33639109
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32851952
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32655943
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32469561
70KDM2B_26808549_Chip-Seq_REH_Human1.31915965
71GATA3_21867929_ChIP-Seq_CD8_Mouse1.31346727
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30594639
73STAT3_23295773_ChIP-Seq_U87_Human1.29803109
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29422958
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.28986960
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.28034112
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27805579
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27123158
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26408109
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25763451
81VDR_23849224_ChIP-Seq_CD4+_Human1.24123115
82MYC_18940864_ChIP-ChIP_HL60_Human1.23618914
83TCF4_23295773_ChIP-Seq_U87_Human1.22779791
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18616137
85TCF4_22108803_ChIP-Seq_LS180_Human1.18297895
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.18215854
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17211965
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.17063519
89SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16919173
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.16591388
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.16315722
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.15985779
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.15590704
94ELK1_19687146_ChIP-ChIP_HELA_Human1.15462846
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14923508
96RUNX2_22187159_ChIP-Seq_PCA_Human1.14649941
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13856724
98LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13693516
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13364531
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13147729
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12128488
102FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11598255
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10679027
104AR_21572438_ChIP-Seq_LNCaP_Human1.09575819
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09380467
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09380467
107P53_22387025_ChIP-Seq_ESCs_Mouse1.09102414
108NCOR_22424771_ChIP-Seq_293T_Human1.08396856
109P300_18555785_Chip-Seq_ESCs_Mouse1.08359326
110RNF2_27304074_Chip-Seq_NSC_Mouse1.08259881
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08126150
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07720305
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.07673982
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.07097506
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07022883
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.06983618
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.06302432
118GF1_26923725_Chip-Seq_HPCs_Mouse1.06013602
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05858256
120P53_21459846_ChIP-Seq_SAOS-2_Human1.05682592
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05617502
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05531047
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04872454
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.04221664
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03948810
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.03168104
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03009214
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02881387
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.02881387
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.02120723
131GATA3_21878914_ChIP-Seq_MCF-7_Human1.02029466
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01690528
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01187355
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00285749
135NOTCH1_21737748_ChIP-Seq_TLL_Human1.00159841
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.00106264
137RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00026053
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.99986186
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98705997
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98460767
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96828670
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96805640
143CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96655385
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95662942
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94751154
146NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94248831
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93496235
148NFYB_21822215_ChIP-Seq_K562_Human0.92888635
149RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92740101
150PU1_27457419_Chip-Seq_LIVER_Mouse0.92058269
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.91536476
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90823687
153SOX2_18555785_Chip-Seq_ESCs_Mouse0.89497038
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.89370697
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.89024219
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88977726
157CTCF_18555785_Chip-Seq_ESCs_Mouse0.88676802
158SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88527259
159TBL1_22424771_ChIP-Seq_293T_Human0.88376030
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.87738025
161E2F1_18555785_Chip-Seq_ESCs_Mouse0.86679948
162PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86584028
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85795782
164EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85469753
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.84645920
166SOX9_26525672_Chip-Seq_HEART_Mouse0.84456106
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84067676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.95218883
2MP0001929_abnormal_gametogenesis5.48612468
3MP0008877_abnormal_DNA_methylation5.30390549
4MP0002210_abnormal_sex_determination3.74422327
5MP0002653_abnormal_ependyma_morphology3.28650450
6MP0002161_abnormal_fertility/fecundity3.21827792
7MP0001145_abnormal_male_reproductive3.16393751
8MP0003880_abnormal_central_pattern2.86823518
9MP0000653_abnormal_sex_gland2.74766526
10MP0002837_dystrophic_cardiac_calcinosis2.12595270
11MP0003136_yellow_coat_color2.10745780
12MP0005623_abnormal_meninges_morphology2.07387021
13MP0005410_abnormal_fertilization15.3117594
14MP0002638_abnormal_pupillary_reflex1.93503906
15MP0004885_abnormal_endolymph1.91942340
16MP0004142_abnormal_muscle_tone1.91262548
17MP0006292_abnormal_olfactory_placode1.86817990
18MP0006276_abnormal_autonomic_nervous1.81041508
19MP0005670_abnormal_white_adipose1.75918856
20MP0008789_abnormal_olfactory_epithelium1.75595666
21MP0003195_calcinosis1.72804054
22MP0002735_abnormal_chemical_nociception1.70250374
23MP0009745_abnormal_behavioral_response1.69733325
24MP0000778_abnormal_nervous_system1.67229441
25MP0004147_increased_porphyrin_level1.65960896
26MP0002160_abnormal_reproductive_system1.61931319
27MP0000631_abnormal_neuroendocrine_gland1.57912574
28MP0008057_abnormal_DNA_replication1.54219441
29MP0001486_abnormal_startle_reflex1.52983448
30MP0002876_abnormal_thyroid_physiology1.49884442
31MP0002938_white_spotting1.47330420
32MP0001485_abnormal_pinna_reflex1.46975007
33MP0002163_abnormal_gland_morphology1.45759552
34MP0000569_abnormal_digit_pigmentation1.45743882
35MP0003646_muscle_fatigue1.43103672
36MP0009046_muscle_twitch1.41821041
37MP0005394_taste/olfaction_phenotype1.40695093
38MP0005499_abnormal_olfactory_system1.40695093
39MP0000372_irregular_coat_pigmentation1.40142027
40MP0008872_abnormal_physiological_respon1.35472058
41MP0002282_abnormal_trachea_morphology1.33530758
42MP0002067_abnormal_sensory_capabilities1.32786921
43MP0008058_abnormal_DNA_repair1.31516973
44MP0002557_abnormal_social/conspecific_i1.28698920
45MP0003635_abnormal_synaptic_transmissio1.24784801
46MP0002734_abnormal_mechanical_nocicepti1.20842378
47MP0001905_abnormal_dopamine_level1.19926072
48MP0002751_abnormal_autonomic_nervous1.19682154
49MP0002064_seizures1.17763668
50MP0004233_abnormal_muscle_weight1.17457986
51MP0008875_abnormal_xenobiotic_pharmacok1.17226811
52MP0005386_behavior/neurological_phenoty1.16063495
53MP0004924_abnormal_behavior1.16063495
54MP0005647_abnormal_sex_gland1.14902181
55MP0010094_abnormal_chromosome_stability1.14866110
56MP0000026_abnormal_inner_ear1.14231370
57MP0001970_abnormal_pain_threshold1.14028877
58MP0003121_genomic_imprinting1.13883705
59MP0005379_endocrine/exocrine_gland_phen1.11394870
60MP0005084_abnormal_gallbladder_morpholo1.11134793
61MP0004215_abnormal_myocardial_fiber1.10138918
62MP0001984_abnormal_olfaction1.09582574
63MP0002063_abnormal_learning/memory/cond1.07126545
64MP0003119_abnormal_digestive_system1.06941197
65MP0002184_abnormal_innervation1.05456257
66MP0003011_delayed_dark_adaptation1.05117775
67MP0002733_abnormal_thermal_nociception1.04972253
68MP0001963_abnormal_hearing_physiology1.04642266
69MP0000049_abnormal_middle_ear1.01635032
70MP0002752_abnormal_somatic_nervous1.01597140
71MP0003122_maternal_imprinting1.01164217
72MP0005187_abnormal_penis_morphology1.00440524
73MP0005174_abnormal_tail_pigmentation1.00069449
74MP0001986_abnormal_taste_sensitivity0.99099482
75MP0008995_early_reproductive_senescence0.95285338
76MP0001765_abnormal_ion_homeostasis0.95084512
77MP0000566_synostosis0.93965096
78MP0005645_abnormal_hypothalamus_physiol0.93262907
79MP0000749_muscle_degeneration0.89495666
80MP0002095_abnormal_skin_pigmentation0.88806423
81MP0005389_reproductive_system_phenotype0.88288805
82MP0003937_abnormal_limbs/digits/tail_de0.88241131
83MP0003718_maternal_effect0.87791521
84MP0002882_abnormal_neuron_morphology0.86343781
85MP0002102_abnormal_ear_morphology0.86142566
86MP0003329_amyloid_beta_deposits0.85884790
87MP0003137_abnormal_impulse_conducting0.85375190
88MP0005377_hearing/vestibular/ear_phenot0.84056288
89MP0003878_abnormal_ear_physiology0.84056288
90MP0003786_premature_aging0.72825779
91MP0002234_abnormal_pharynx_morphology0.70147133
92MP0008007_abnormal_cellular_replicative0.65654612
93MP0003111_abnormal_nucleus_morphology0.63841965
94MP0003950_abnormal_plasma_membrane0.63627716
95MP0005551_abnormal_eye_electrophysiolog0.60526756
96MP0005253_abnormal_eye_physiology0.60402446
97MP0002132_abnormal_respiratory_system0.58073246
98MP0000358_abnormal_cell_content/0.55576142
99MP0002971_abnormal_brown_adipose0.54787498
100MP0004145_abnormal_muscle_electrophysio0.52269900
101MP0005636_abnormal_mineral_homeostasis0.52084151
102MP0006036_abnormal_mitochondrial_physio0.51703741
103MP0004036_abnormal_muscle_relaxation0.51515504
104MP0003699_abnormal_female_reproductive0.50316693
105MP0001661_extended_life_span0.49075143
106MP0001324_abnormal_eye_pigmentation0.46994729
107MP0003115_abnormal_respiratory_system0.43225371
108MP0006035_abnormal_mitochondrial_morpho0.42694069
109MP0005391_vision/eye_phenotype0.42363849
110MP0001119_abnormal_female_reproductive0.41356304
111MP0009278_abnormal_bone_marrow0.41110304
112MP0005397_hematopoietic_system_phenotyp0.41039528
113MP0001545_abnormal_hematopoietic_system0.41039528
114MP0003879_abnormal_hair_cell0.40580851
115MP0001293_anophthalmia0.40453994
116MP0004134_abnormal_chest_morphology0.39265206
117MP0003631_nervous_system_phenotype0.39143631
118MP0002736_abnormal_nociception_after0.38701657
119MP0003787_abnormal_imprinting0.36575020
120MP0000604_amyloidosis0.35543825
121MP0000534_abnormal_ureter_morphology0.35103075
122MP0003633_abnormal_nervous_system0.34996104
123MP0003861_abnormal_nervous_system0.34813815
124MP0002152_abnormal_brain_morphology0.34458590
125MP0001764_abnormal_homeostasis0.33802948
126MP0006072_abnormal_retinal_apoptosis0.33606964
127MP0004808_abnormal_hematopoietic_stem0.33480875
128MP0003693_abnormal_embryo_hatching0.33470963
129MP0003632_abnormal_nervous_system0.32919142
130MP0004742_abnormal_vestibular_system0.32145835
131MP0003077_abnormal_cell_cycle0.30812734
132MP0005423_abnormal_somatic_nervous0.30718854
133MP0009115_abnormal_fat_cell0.30547146
134MP0002928_abnormal_bile_duct0.30493002
135MP0001440_abnormal_grooming_behavior0.30466960
136MP0001727_abnormal_embryo_implantation0.30412947
137MP0005195_abnormal_posterior_eye0.30225074
138MP0004133_heterotaxia0.30165196
139MP0002572_abnormal_emotion/affect_behav0.28411397
140MP0001730_embryonic_growth_arrest0.28397109
141MP0004019_abnormal_vitamin_homeostasis0.27216791
142MP0010307_abnormal_tumor_latency0.26773215
143MP0002822_catalepsy0.26511487
144MP0003045_fibrosis0.25917922
145MP0004043_abnormal_pH_regulation0.25108653
146MP0000647_abnormal_sebaceous_gland0.24951176
147MP0002229_neurodegeneration0.24867926
148MP0002269_muscular_atrophy0.24259905
149MP0001968_abnormal_touch/_nociception0.24193116
150MP0005666_abnormal_adipose_tissue0.23903511
151MP0000313_abnormal_cell_death0.23893491
152MP0004811_abnormal_neuron_physiology0.23806611
153MP0002272_abnormal_nervous_system0.23047743
154MP0003942_abnormal_urinary_system0.20643870
155MP0000955_abnormal_spinal_cord0.20298676
156MP0005646_abnormal_pituitary_gland0.19758727
157MP0001529_abnormal_vocalization0.17972170
158MP0004270_analgesia0.17960322
159MP0002295_abnormal_pulmonary_circulatio0.17761080
160MP0002169_no_abnormal_phenotype0.16975075

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39361748
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80282916
3Abnormal respiratory epithelium morphology (HP:0012253)8.80282916
4Rhinitis (HP:0012384)7.86974102
5Abnormal ciliary motility (HP:0012262)7.58782222
6Chronic bronchitis (HP:0004469)7.07291517
7Infertility (HP:0000789)6.34364118
8Nasal polyposis (HP:0100582)6.26246212
9Abnormality of the nasal mucosa (HP:0000433)5.11330205
10Bronchiectasis (HP:0002110)4.68418434
11Bronchitis (HP:0012387)4.52734450
12Nephronophthisis (HP:0000090)4.35729541
13True hermaphroditism (HP:0010459)4.01348726
14Pancreatic cysts (HP:0001737)3.97547114
15Male infertility (HP:0003251)3.49985213
16Type II lissencephaly (HP:0007260)3.46624926
17Recurrent otitis media (HP:0000403)3.37910458
18Abnormality of the renal medulla (HP:0100957)3.34880842
19Recurrent sinusitis (HP:0011108)3.33964756
20Hyperglycinemia (HP:0002154)3.22587330
21Abnormal spermatogenesis (HP:0008669)3.11466152
22Pendular nystagmus (HP:0012043)3.01973684
23Acute necrotizing encephalopathy (HP:0006965)2.91740812
24Tubulointerstitial nephritis (HP:0001970)2.91160221
25Abnormality of the lower motor neuron (HP:0002366)2.88303187
26Gonadotropin excess (HP:0000837)2.83829012
27Recurrent bronchitis (HP:0002837)2.83029739
28Mitochondrial inheritance (HP:0001427)2.81758331
29Medial flaring of the eyebrow (HP:0010747)2.72645777
30Acute encephalopathy (HP:0006846)2.71555006
31Increased CSF lactate (HP:0002490)2.62860581
32Molar tooth sign on MRI (HP:0002419)2.60113017
33Abnormality of midbrain morphology (HP:0002418)2.60113017
34Abnormal mitochondria in muscle tissue (HP:0008316)2.56570431
35Impulsivity (HP:0100710)2.52633893
36Abnormality of the labia minora (HP:0012880)2.50400217
373-Methylglutaconic aciduria (HP:0003535)2.50354462
38Hyperventilation (HP:0002883)2.50187153
39Hepatic necrosis (HP:0002605)2.50020653
40Lissencephaly (HP:0001339)2.49794068
41Tubulointerstitial abnormality (HP:0001969)2.49290666
42Hepatocellular necrosis (HP:0001404)2.47514282
43Chronic hepatic failure (HP:0100626)2.47513541
44Progressive macrocephaly (HP:0004481)2.46550122
45Tubular atrophy (HP:0000092)2.46539068
46Renal cortical cysts (HP:0000803)2.46109244
47Lipid accumulation in hepatocytes (HP:0006561)2.42487680
48Congenital stationary night blindness (HP:0007642)2.41900901
49Cerebellar dysplasia (HP:0007033)2.39434156
50Sclerocornea (HP:0000647)2.36160057
51Azoospermia (HP:0000027)2.34952860
52Fibular hypoplasia (HP:0003038)2.33602727
53Increased hepatocellular lipid droplets (HP:0006565)2.32294222
54Amyotrophic lateral sclerosis (HP:0007354)2.32268421
55Abolished electroretinogram (ERG) (HP:0000550)2.27899095
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.24193625
57Inability to walk (HP:0002540)2.24046158
58Hyperglycinuria (HP:0003108)2.23306869
59Occipital encephalocele (HP:0002085)2.22711614
60Focal motor seizures (HP:0011153)2.21558419
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20983232
62Colon cancer (HP:0003003)2.18505916
63Short tibia (HP:0005736)2.17374478
64Anencephaly (HP:0002323)2.16641645
65Oligodactyly (hands) (HP:0001180)2.14321286
66Postaxial foot polydactyly (HP:0001830)2.08451741
67Abnormality of serine family amino acid metabolism (HP:0010894)2.07946875
68Abnormality of glycine metabolism (HP:0010895)2.07946875
69Vaginal atresia (HP:0000148)2.07908341
70Methylmalonic aciduria (HP:0012120)2.04146436
71Male pseudohermaphroditism (HP:0000037)2.02295681
72Tubulointerstitial fibrosis (HP:0005576)2.00704902
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5907542
74Absent/shortened dynein arms (HP:0200106)12.4245119
75Dynein arm defect of respiratory motile cilia (HP:0012255)12.4245119
76Optic disc pallor (HP:0000543)1.97598770
77Abnormality of permanent molar morphology (HP:0011071)1.96559086
78Abnormality of the dental root (HP:0006486)1.96559086
79Taurodontia (HP:0000679)1.96559086
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.96270413
81Severe muscular hypotonia (HP:0006829)1.93101911
82Stage 5 chronic kidney disease (HP:0003774)1.92349432
83Absent frontal sinuses (HP:0002688)1.92299614
84Congenital hepatic fibrosis (HP:0002612)1.92201542
85Microglossia (HP:0000171)1.92056723
86Methylmalonic acidemia (HP:0002912)1.91677214
87Spastic tetraparesis (HP:0001285)1.91536325
88Increased serum lactate (HP:0002151)1.91125844
89Broad-based gait (HP:0002136)1.90583574
90Aplasia/hypoplasia of the uterus (HP:0008684)1.90392728
91Abnormality of dentin (HP:0010299)1.89820208
92Keratoconus (HP:0000563)1.89723406
93Increased corneal curvature (HP:0100692)1.89723406
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.89599528
95Lactic acidosis (HP:0003128)1.89288611
96Anophthalmia (HP:0000528)1.85812547
97Optic nerve hypoplasia (HP:0000609)1.84667948
98Impaired proprioception (HP:0010831)1.84381258
99Facial cleft (HP:0002006)1.83694876
100Intestinal atresia (HP:0011100)1.82945350
101Abnormality of molar (HP:0011077)1.82648534
102Abnormality of molar morphology (HP:0011070)1.82648534
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82514522
104Abnormality of alanine metabolism (HP:0010916)1.82514522
105Hyperalaninemia (HP:0003348)1.82514522
106Bilateral microphthalmos (HP:0007633)1.82114445
107J-shaped sella turcica (HP:0002680)1.81249858
108Progressive cerebellar ataxia (HP:0002073)1.80550979
109Renal dysplasia (HP:0000110)1.80082482
110Gaze-evoked nystagmus (HP:0000640)1.80034809
111Polyphagia (HP:0002591)1.79628990
112Abnormal rod and cone electroretinograms (HP:0008323)1.79263500
113Polyuria (HP:0000103)1.78778154
114Cerebral edema (HP:0002181)1.77921773
115Chronic sinusitis (HP:0011109)1.77814671
116Abnormality of the dental pulp (HP:0006479)1.77734836
117Oculomotor apraxia (HP:0000657)1.76211390
118Short ribs (HP:0000773)1.76113927
119Renal Fanconi syndrome (HP:0001994)1.75792840
120Hypothermia (HP:0002045)1.74698742
121Absent epiphyses (HP:0010577)1.73974512
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73974512
123Polydipsia (HP:0001959)1.72425918
124Abnormal drinking behavior (HP:0030082)1.72425918
125Astigmatism (HP:0000483)1.71407082
126Supernumerary spleens (HP:0009799)1.69083518
127Abnormality of the renal cortex (HP:0011035)1.69012840
128Postaxial hand polydactyly (HP:0001162)1.64838191
129Abnormal gallbladder physiology (HP:0012438)1.61718194
130Cholecystitis (HP:0001082)1.61718194
131Dyschromatopsia (HP:0007641)1.60970967
132Upper motor neuron abnormality (HP:0002127)1.59673315
133Median cleft lip (HP:0000161)1.59581549
134Congenital primary aphakia (HP:0007707)1.58330676
135Gait imbalance (HP:0002141)1.56653231
136Abnormality of the anterior horn cell (HP:0006802)1.55275235
137Degeneration of anterior horn cells (HP:0002398)1.55275235
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.49332180
139Progressive inability to walk (HP:0002505)1.48803010
140Abnormality of renal excretion (HP:0011036)1.46531038
141Pancreatic fibrosis (HP:0100732)1.44944641
142Bell-shaped thorax (HP:0001591)1.44471945
14311 pairs of ribs (HP:0000878)1.44115298
144Short thorax (HP:0010306)1.43090457
145Decreased central vision (HP:0007663)1.42456878
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.42221349
147Heterotopia (HP:0002282)1.42141932
148Aplasia/Hypoplasia of the lens (HP:0008063)1.41998132
149Bile duct proliferation (HP:0001408)1.41810867
150Abnormal biliary tract physiology (HP:0012439)1.41810867
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.41440752
152Broad distal phalanx of finger (HP:0009836)1.39985965
153Neurofibrillary tangles (HP:0002185)1.37276179
154Deformed sella turcica (HP:0002681)1.35495364
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34825516
156Abnormality of ocular smooth pursuit (HP:0000617)1.34132202
157Nephropathy (HP:0000112)1.33353728
158Delayed gross motor development (HP:0002194)1.32962048
159Nephrogenic diabetes insipidus (HP:0009806)1.29842236
160Retinal dysplasia (HP:0007973)1.29478447
161Hemiparesis (HP:0001269)1.27775451
162Short femoral neck (HP:0100864)1.27194773
163Cystic liver disease (HP:0006706)1.27140511
164Genital tract atresia (HP:0001827)1.25728665
165Choroideremia (HP:0001139)1.25424135
166Pachygyria (HP:0001302)1.23390244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.46383546
2PDK38.46383546
3PDK25.53828676
4TESK14.99528059
5PRKD34.18363389
6MAP4K24.00806808
7ICK3.55803448
8FRK2.80611729
9STK392.79977673
10CASK2.73482440
11PNCK2.60145963
12MARK12.57013992
13ADRBK22.56602028
14WNK42.53370191
15PTK2B2.50379157
16MAPK132.10996821
17NEK21.96786920
18EPHA41.95132265
19INSRR1.92741256
20DYRK21.89055986
21GRK11.78959180
22NUAK11.70853079
23BCKDK1.59572837
24PAK31.58098224
25OBSCN1.55632331
26VRK11.53968217
27STK381.53712986
28ZAK1.48439556
29TRIM281.45703827
30TAOK31.43898590
31VRK21.40525739
32CSNK1G21.36795076
33DYRK1B1.33413246
34BCR1.27007133
35WNK11.26038236
36MAPK151.23578377
37PHKG21.12938108
38PHKG11.12938108
39TIE11.11453243
40EPHA31.08546587
41CSNK1G11.07076310
42DAPK21.06304678
43CSNK1G31.05871959
44CCNB11.04256753
45MAP3K121.00940821
46PDK11.00185913
47WEE10.99428765
48ERBB30.96306151
49CDK80.92837040
50TYRO30.91413489
51SRPK10.90895221
52DYRK30.90028842
53ADRBK10.89749254
54PLK20.86226656
55PASK0.85796052
56ACVR1B0.85013071
57TTK0.83322722
58CSNK1A1L0.83140008
59PRKCE0.82708440
60NEK10.82480855
61TLK10.80881279
62STK30.80192932
63MAP2K40.79802359
64CDK190.76853494
65MUSK0.75553123
66CAMKK20.74525205
67CDC70.72277799
68TNIK0.71736786
69CHEK20.64984377
70PINK10.64395055
71IRAK10.64303407
72TGFBR10.64295387
73TESK20.64120656
74PLK30.62059781
75BRSK20.60961237
76LIMK10.58217402
77CHEK10.57453022
78PLK40.54715410
79NTRK30.53047724
80GRK50.51642933
81ATR0.51061310
82CSNK1A10.49904327
83RPS6KA50.49580561
84PDPK10.49346325
85BMPR1B0.48593141
86MINK10.44789571
87PAK60.44514124
88UHMK10.43875122
89AKT30.43237911
90NTRK20.43226269
91CAMK10.42671663
92CAMK1G0.40034256
93LMTK20.39423258
94CDK50.37481937
95PRKAA20.36983187
96STK38L0.36812080
97PAK10.36470961
98NEK60.35943883
99PIK3CA0.35583341
100RIPK40.35374499
101FGFR20.34295533
102KIT0.34285798
103RPS6KA40.34257010
104ATM0.33753905
105GRK70.33533877
106SGK2230.33263537
107PLK10.32909637
108MAPKAPK50.30234656
109BRSK10.29569534
110BUB10.26426842
111CDK120.25296614
112PRKCG0.25201082
113MARK20.24594487
114MAP2K60.24594334
115PRKAA10.22519739
116MTOR0.21776193
117PAK20.21038705
118IRAK20.20431255
119CAMKK10.19712553
120PRKCQ0.19499125
121CDK30.16491745
122RPS6KB10.14556455
123OXSR10.12345248
124PKN10.11875307
125CDK10.11405806
126EEF2K0.10708733
127CDK150.10264688
128CSNK2A10.09473635
129BRAF0.09353822
130DYRK1A0.08744439
131CSNK1D0.08523380
132CAMK2A0.08093841
133CDK20.07898909
134GSK3B0.07666125
135PRKG10.07322464
136CDK180.07253093
137CDK11A0.07160507
138MAPK80.06047292
139ZAP700.05968082
140WNK30.04842665
141STK110.04795920
142CDK140.04480253
143CSNK2A20.04241655
144PRKDC0.04018788
145MAPK100.03989369
146PRKACG0.02862972
147PAK40.02771845
148AURKA0.02617654
149CLK10.02370034
150RPS6KA10.02293012
151STK160.02187708
152AURKB0.02114977
153PRKACB0.01981172
154CDK60.01316886
155PRKCA0.01169099
156MAP2K70.01010695
157PRKCB0.00916044
158CSF1R0.00404990
159MARK30.00111061
160MAP3K4-0.0125033
161PRKCZ-0.0095579
162PRKACA-0.0092525
163CDK4-0.0033888

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.20869949
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.71093731
3Pyruvate metabolism_Homo sapiens_hsa006203.64818769
4Basal transcription factors_Homo sapiens_hsa030223.17453050
5Fatty acid biosynthesis_Homo sapiens_hsa000613.14989512
6Parkinsons disease_Homo sapiens_hsa050122.86849115
7Propanoate metabolism_Homo sapiens_hsa006402.83401105
8Fanconi anemia pathway_Homo sapiens_hsa034602.77528451
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76012132
10Linoleic acid metabolism_Homo sapiens_hsa005912.70223014
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69781837
12Selenocompound metabolism_Homo sapiens_hsa004502.67354036
13Protein export_Homo sapiens_hsa030602.56258245
14Glucagon signaling pathway_Homo sapiens_hsa049222.51019724
15Dorso-ventral axis formation_Homo sapiens_hsa043202.50974603
16Pentose phosphate pathway_Homo sapiens_hsa000302.48190529
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46346536
18Butanoate metabolism_Homo sapiens_hsa006502.40482898
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25499561
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16491064
21Huntingtons disease_Homo sapiens_hsa050162.15253872
22Phototransduction_Homo sapiens_hsa047442.02651024
23Glycerolipid metabolism_Homo sapiens_hsa005612.02141955
24Oocyte meiosis_Homo sapiens_hsa041141.98691746
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.90385121
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82186425
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.76939493
28RNA polymerase_Homo sapiens_hsa030201.76684410
29Caffeine metabolism_Homo sapiens_hsa002321.73220141
30Amphetamine addiction_Homo sapiens_hsa050311.71026693
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68383880
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62555848
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54593713
34Tryptophan metabolism_Homo sapiens_hsa003801.51782750
35Ether lipid metabolism_Homo sapiens_hsa005651.50994257
36Cardiac muscle contraction_Homo sapiens_hsa042601.49424402
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47313894
38Nitrogen metabolism_Homo sapiens_hsa009101.47111396
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46454263
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44477397
41RNA transport_Homo sapiens_hsa030131.44016801
42Regulation of autophagy_Homo sapiens_hsa041401.41112280
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.40836234
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34382875
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34190206
46Fructose and mannose metabolism_Homo sapiens_hsa000511.33956154
47mRNA surveillance pathway_Homo sapiens_hsa030151.32591316
48Ribosome_Homo sapiens_hsa030101.32020706
49PPAR signaling pathway_Homo sapiens_hsa033201.30424508
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29797594
51Peroxisome_Homo sapiens_hsa041461.28270657
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27557637
53Purine metabolism_Homo sapiens_hsa002301.26207785
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21829191
55Renin secretion_Homo sapiens_hsa049241.21332848
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.19570284
57Fatty acid elongation_Homo sapiens_hsa000621.15768649
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15018532
59Carbon metabolism_Homo sapiens_hsa012001.13861170
60Steroid biosynthesis_Homo sapiens_hsa001001.13519986
61Mismatch repair_Homo sapiens_hsa034301.12669070
62Mineral absorption_Homo sapiens_hsa049781.08474504
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06623274
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03854201
65Olfactory transduction_Homo sapiens_hsa047401.03635491
66GABAergic synapse_Homo sapiens_hsa047271.02625053
67Morphine addiction_Homo sapiens_hsa050321.02496036
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98436089
69Antigen processing and presentation_Homo sapiens_hsa046120.97458527
70beta-Alanine metabolism_Homo sapiens_hsa004100.96464421
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.96314261
72Fat digestion and absorption_Homo sapiens_hsa049750.95769731
73ABC transporters_Homo sapiens_hsa020100.94994262
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.91017838
75Long-term potentiation_Homo sapiens_hsa047200.90037294
76Base excision repair_Homo sapiens_hsa034100.89758718
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88817782
78Pyrimidine metabolism_Homo sapiens_hsa002400.87004804
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85713983
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85609418
81Fatty acid metabolism_Homo sapiens_hsa012120.83381792
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80442718
83Collecting duct acid secretion_Homo sapiens_hsa049660.80072034
84Arachidonic acid metabolism_Homo sapiens_hsa005900.78887021
85Taste transduction_Homo sapiens_hsa047420.78722133
86Biosynthesis of amino acids_Homo sapiens_hsa012300.77913757
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76576228
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71949644
89Calcium signaling pathway_Homo sapiens_hsa040200.71709274
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71659909
91Homologous recombination_Homo sapiens_hsa034400.70326147
92Sulfur relay system_Homo sapiens_hsa041220.70168343
93Glutathione metabolism_Homo sapiens_hsa004800.69554848
94Systemic lupus erythematosus_Homo sapiens_hsa053220.69253829
95Retinol metabolism_Homo sapiens_hsa008300.68178481
96One carbon pool by folate_Homo sapiens_hsa006700.65378341
97DNA replication_Homo sapiens_hsa030300.64120667
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63513884
99Hedgehog signaling pathway_Homo sapiens_hsa043400.63507004
100Arginine and proline metabolism_Homo sapiens_hsa003300.62230027
101Renin-angiotensin system_Homo sapiens_hsa046140.61830370
102Estrogen signaling pathway_Homo sapiens_hsa049150.60388505
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58610315
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58476603
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57864126
106Basal cell carcinoma_Homo sapiens_hsa052170.54808889
107Circadian rhythm_Homo sapiens_hsa047100.53179725
108RNA degradation_Homo sapiens_hsa030180.53005562
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52421232
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51897935
111Inositol phosphate metabolism_Homo sapiens_hsa005620.51816690
112Dopaminergic synapse_Homo sapiens_hsa047280.50346115
113Fatty acid degradation_Homo sapiens_hsa000710.49831626
114Insulin secretion_Homo sapiens_hsa049110.48537461
115Ovarian steroidogenesis_Homo sapiens_hsa049130.48506178
116Serotonergic synapse_Homo sapiens_hsa047260.48388271
117Metabolic pathways_Homo sapiens_hsa011000.48207271
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44114836
119N-Glycan biosynthesis_Homo sapiens_hsa005100.44090684
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42960939
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42619185
122Legionellosis_Homo sapiens_hsa051340.42534761
123Chemical carcinogenesis_Homo sapiens_hsa052040.42099924
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.40686396
125Circadian entrainment_Homo sapiens_hsa047130.39296068
126Endocytosis_Homo sapiens_hsa041440.38746360
127Cell cycle_Homo sapiens_hsa041100.38634603
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38047915
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.36850269
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.36504322
131VEGF signaling pathway_Homo sapiens_hsa043700.34974717
132Non-homologous end-joining_Homo sapiens_hsa034500.34963834
133Salivary secretion_Homo sapiens_hsa049700.34206515
134Pancreatic secretion_Homo sapiens_hsa049720.34171536
135Spliceosome_Homo sapiens_hsa030400.33645918
136Alzheimers disease_Homo sapiens_hsa050100.33454625
137Folate biosynthesis_Homo sapiens_hsa007900.33206829
138Glutamatergic synapse_Homo sapiens_hsa047240.31681760
139Thyroid hormone synthesis_Homo sapiens_hsa049180.30749562
140Synaptic vesicle cycle_Homo sapiens_hsa047210.30275234
141Alcoholism_Homo sapiens_hsa050340.28530878
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28229459
143Cocaine addiction_Homo sapiens_hsa050300.27545191
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.27534200
145Sphingolipid metabolism_Homo sapiens_hsa006000.27240508
146Proteasome_Homo sapiens_hsa030500.26267552
147Oxidative phosphorylation_Homo sapiens_hsa001900.23845229
148AMPK signaling pathway_Homo sapiens_hsa041520.23163154
149Protein digestion and absorption_Homo sapiens_hsa049740.23085194
150Bile secretion_Homo sapiens_hsa049760.23016917
151Nicotine addiction_Homo sapiens_hsa050330.21710455
152Viral carcinogenesis_Homo sapiens_hsa052030.20305124
153Nucleotide excision repair_Homo sapiens_hsa034200.17766749
154cAMP signaling pathway_Homo sapiens_hsa040240.17656618

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