MRPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.14331100
2chaperone-mediated protein transport (GO:0072321)5.05032994
3respiratory electron transport chain (GO:0022904)4.59127255
4electron transport chain (GO:0022900)4.48343883
5protein neddylation (GO:0045116)4.41549339
6establishment of integrated proviral latency (GO:0075713)4.19524726
7proteasome assembly (GO:0043248)4.15150279
8regulation of mitochondrial translation (GO:0070129)4.13040956
9purine nucleobase biosynthetic process (GO:0009113)4.04646152
10cullin deneddylation (GO:0010388)4.02580823
11protein deneddylation (GO:0000338)3.89653795
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.85277938
13respiratory chain complex IV assembly (GO:0008535)3.78952614
14CENP-A containing nucleosome assembly (GO:0034080)3.78201704
15chromatin remodeling at centromere (GO:0031055)3.72262532
16nucleobase biosynthetic process (GO:0046112)3.67456341
17pseudouridine synthesis (GO:0001522)3.63715676
18DNA deamination (GO:0045006)3.57072356
19protein targeting to mitochondrion (GO:0006626)3.51869484
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48952635
21cytochrome complex assembly (GO:0017004)3.42345519
22DNA double-strand break processing (GO:0000729)3.40598680
237-methylguanosine mRNA capping (GO:0006370)3.40050542
24* translation (GO:0006412)3.39933610
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39209338
26regulation of cellular amino acid metabolic process (GO:0006521)3.37939310
27kinetochore organization (GO:0051383)3.35796480
28rRNA modification (GO:0000154)3.34226584
29protein localization to mitochondrion (GO:0070585)3.33824636
30RNA capping (GO:0036260)3.33025540
317-methylguanosine RNA capping (GO:0009452)3.33025540
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32909381
33establishment of viral latency (GO:0019043)3.31022162
34inner mitochondrial membrane organization (GO:0007007)3.30754725
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28946166
36mitotic metaphase plate congression (GO:0007080)3.27526697
37establishment of protein localization to mitochondrion (GO:0072655)3.27397545
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26960080
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26960080
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26960080
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25003963
42L-methionine salvage (GO:0071267)3.24695265
43L-methionine biosynthetic process (GO:0071265)3.24695265
44amino acid salvage (GO:0043102)3.24695265
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24579681
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24579681
47DNA replication checkpoint (GO:0000076)3.24148552
48termination of RNA polymerase III transcription (GO:0006386)3.23961498
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.23961498
50rRNA processing (GO:0006364)3.23305157
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.22012629
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21550582
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.21525097
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21030440
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21014898
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.21014898
57cotranslational protein targeting to membrane (GO:0006613)3.20835687
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.18944814
59histone mRNA metabolic process (GO:0008334)3.18034036
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17812977
61DNA ligation (GO:0006266)3.14553194
62telomere maintenance via semi-conservative replication (GO:0032201)3.14282462
63protein targeting to ER (GO:0045047)3.14032413
64cellular component biogenesis (GO:0044085)3.13681203
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12487133
66maturation of SSU-rRNA (GO:0030490)3.11580487
67rRNA metabolic process (GO:0016072)3.11202150
68termination of RNA polymerase I transcription (GO:0006363)3.11199792
69telomere maintenance via recombination (GO:0000722)3.10623627
70histone exchange (GO:0043486)3.09530754
71methionine biosynthetic process (GO:0009086)3.08279684
72IMP biosynthetic process (GO:0006188)3.07720816
73protein complex biogenesis (GO:0070271)3.06911142
74kinetochore assembly (GO:0051382)3.06532435
75regulation of ligase activity (GO:0051340)3.06345505
76formation of translation preinitiation complex (GO:0001731)3.06274141
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04654498
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04476639
79negative regulation of ligase activity (GO:0051352)3.04476639
80DNA replication-independent nucleosome assembly (GO:0006336)3.04451571
81DNA replication-independent nucleosome organization (GO:0034724)3.04451571
82DNA catabolic process, exonucleolytic (GO:0000738)3.03681544
83organelle disassembly (GO:1903008)3.01645576
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01643216
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.01643216
86NADH dehydrogenase complex assembly (GO:0010257)3.01643216
87regulation of mitotic spindle checkpoint (GO:1903504)3.00515217
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00515217
89protein-cofactor linkage (GO:0018065)3.00414282
90ribosome biogenesis (GO:0042254)3.00066871
91translational termination (GO:0006415)2.99363486
92transcription from RNA polymerase I promoter (GO:0006360)2.98755807
93DNA strand elongation involved in DNA replication (GO:0006271)2.98649776
94methionine metabolic process (GO:0006555)2.98612622
95protein localization to endoplasmic reticulum (GO:0070972)2.98590291
96water-soluble vitamin biosynthetic process (GO:0042364)2.98110629
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97949753
98mitochondrial respiratory chain complex assembly (GO:0033108)2.97621498
99ribosome assembly (GO:0042255)2.97380643
100DNA replication initiation (GO:0006270)2.95986030
101ribonucleoprotein complex biogenesis (GO:0022613)2.95802214
102ATP biosynthetic process (GO:0006754)2.94182016
103meiotic chromosome segregation (GO:0045132)2.93064378
1042-deoxyribonucleotide biosynthetic process (GO:0009265)2.92876157
105deoxyribose phosphate biosynthetic process (GO:0046385)2.92876157
106deoxyribonucleotide biosynthetic process (GO:0009263)2.92465079
107translational initiation (GO:0006413)2.91944668
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91875650
109viral transcription (GO:0019083)2.91117770
110viral mRNA export from host cell nucleus (GO:0046784)2.90580562
111transcription-coupled nucleotide-excision repair (GO:0006283)2.90481873
112negative regulation of protein ubiquitination (GO:0031397)2.89573489
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88871903
114ATP synthesis coupled proton transport (GO:0015986)2.88871903
115maturation of 5.8S rRNA (GO:0000460)2.88321852
116positive regulation of ligase activity (GO:0051351)2.86437186
117transcription initiation from RNA polymerase I promoter (GO:0006361)2.85897631
118guanosine-containing compound biosynthetic process (GO:1901070)2.84672924
119spliceosomal complex assembly (GO:0000245)2.84417911
120DNA strand elongation (GO:0022616)2.83940695
121oxidative phosphorylation (GO:0006119)2.83102268
122metaphase plate congression (GO:0051310)2.82985460
123mitotic recombination (GO:0006312)2.82039571
124rRNA methylation (GO:0031167)2.81647884
125ribosomal small subunit assembly (GO:0000028)2.81350062
126pteridine-containing compound biosynthetic process (GO:0042559)2.80909711
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79080893
128ribosomal large subunit biogenesis (GO:0042273)2.78714191
129folic acid metabolic process (GO:0046655)2.77974315
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76692259
131sulfur amino acid biosynthetic process (GO:0000097)2.74191399
132spliceosomal snRNP assembly (GO:0000387)2.74093644
133folic acid-containing compound biosynthetic process (GO:0009396)2.72565941
134RNA-dependent DNA replication (GO:0006278)2.72339023
135deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70730004
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69643458
137DNA damage response, detection of DNA damage (GO:0042769)2.69071927
138tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68284306
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68284306
140G1/S transition of mitotic cell cycle (GO:0000082)2.67625667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26627563
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59310735
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.79835152
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.64649640
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.62565861
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58835317
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40882762
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08359128
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05941642
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.91431071
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81550429
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66925307
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59304078
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58012056
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57803694
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57181988
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55688464
18VDR_23849224_ChIP-Seq_CD4+_Human2.52652922
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39241986
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.39052563
21* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36403628
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32742843
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32419864
24ELK1_19687146_ChIP-ChIP_HELA_Human2.29652775
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29367021
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26871309
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22422032
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16519263
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.14593910
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14584091
31DCP1A_22483619_ChIP-Seq_HELA_Human2.10522652
32EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05275054
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03549429
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03032144
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99152099
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95568753
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.88085244
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85624938
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80884572
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80093191
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79778369
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78514143
43GABP_19822575_ChIP-Seq_HepG2_Human1.75246211
44* XRN2_22483619_ChIP-Seq_HELA_Human1.74284717
45ZNF274_21170338_ChIP-Seq_K562_Hela1.74010383
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70920756
47* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70279076
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69968029
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66790126
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66188595
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.59371352
52AR_21909140_ChIP-Seq_LNCAP_Human1.55770315
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53935071
54VDR_22108803_ChIP-Seq_LS180_Human1.52547963
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45976362
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45147835
57* TTF2_22483619_ChIP-Seq_HELA_Human1.43875248
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43415134
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.37989119
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32806570
61IGF1R_20145208_ChIP-Seq_DFB_Human1.32268920
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28887216
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28857750
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28347318
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.25816941
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24561335
67MYC_18940864_ChIP-ChIP_HL60_Human1.23579213
68* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20114920
69* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18078472
70* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16901058
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.16847884
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.15680608
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15417304
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.11417338
75TAF15_26573619_Chip-Seq_HEK293_Human1.07759058
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03192710
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03128107
78IRF1_19129219_ChIP-ChIP_H3396_Human1.02796108
79KDM5A_27292631_Chip-Seq_BREAST_Human1.02528755
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.02164236
81* SOX17_20123909_ChIP-Seq_XEN_Mouse1.01790234
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01537130
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01190426
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99459386
85HTT_18923047_ChIP-ChIP_STHdh_Human0.98398756
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97971286
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.94233184
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91139425
89TP53_22573176_ChIP-Seq_HFKS_Human0.90747792
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90545124
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89834213
92P300_19829295_ChIP-Seq_ESCs_Human0.88405798
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88329521
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88241257
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85939181
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82525640
97TFEB_21752829_ChIP-Seq_HELA_Human0.82492218
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81324444
99CIITA_25753668_ChIP-Seq_RAJI_Human0.81224773
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80890824
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.80263806
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79270048
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78385470
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77940004
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77381883
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77284990
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76365758
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76194930
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74745723
110* ELF5_23300383_ChIP-Seq_T47D_Human0.73558588
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72923358
112FUS_26573619_Chip-Seq_HEK293_Human0.72893240
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.71641969
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70116264
115* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70053389
116EWS_26573619_Chip-Seq_HEK293_Human0.66716925
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65438777
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65125808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.94458649
2MP0003693_abnormal_embryo_hatching4.28158953
3MP0002139_abnormal_hepatobiliary_system3.62191618
4MP0009697_abnormal_copulation3.49229796
5MP0008058_abnormal_DNA_repair3.37967357
6MP0010094_abnormal_chromosome_stability3.26876627
7MP0004957_abnormal_blastocyst_morpholog3.10467294
8MP0008057_abnormal_DNA_replication2.96006567
9MP0005085_abnormal_gallbladder_physiolo2.87138221
10MP0001986_abnormal_taste_sensitivity2.75216020
11MP0003111_abnormal_nucleus_morphology2.65699556
12MP0001764_abnormal_homeostasis2.56478972
13MP0003186_abnormal_redox_activity2.51819588
14MP0003077_abnormal_cell_cycle2.50475788
15MP0003195_calcinosis2.44214155
16MP0006072_abnormal_retinal_apoptosis2.41423230
17MP0008877_abnormal_DNA_methylation2.21739960
18MP0005408_hypopigmentation2.21156380
19MP0003718_maternal_effect2.19600797
20MP0005360_urolithiasis2.17982758
21MP0005365_abnormal_bile_salt2.12403078
22MP0006036_abnormal_mitochondrial_physio2.07035308
23MP0006292_abnormal_olfactory_placode2.06571221
24MP0002102_abnormal_ear_morphology2.05914318
25MP0008932_abnormal_embryonic_tissue2.02126470
26MP0003786_premature_aging1.96315037
27MP0008007_abnormal_cellular_replicative1.91753462
28MP0002938_white_spotting1.88545572
29MP0008995_early_reproductive_senescence1.77912468
30MP0000566_synostosis1.73080349
31MP0005332_abnormal_amino_acid1.67046648
32MP0008875_abnormal_xenobiotic_pharmacok1.63935170
33MP0004145_abnormal_muscle_electrophysio1.63642923
34MP0001293_anophthalmia1.56818693
35MP0006035_abnormal_mitochondrial_morpho1.56757889
36MP0002876_abnormal_thyroid_physiology1.56041845
37MP0004215_abnormal_myocardial_fiber1.51016417
38MP0008789_abnormal_olfactory_epithelium1.49818736
39MP0003121_genomic_imprinting1.46454799
40MP0009379_abnormal_foot_pigmentation1.46054439
41MP0003941_abnormal_skin_development1.42882053
42MP0005389_reproductive_system_phenotype1.39382957
43MP0003123_paternal_imprinting1.37606966
44MP0003890_abnormal_embryonic-extraembry1.34968370
45MP0003880_abnormal_central_pattern1.34111043
46MP0002736_abnormal_nociception_after1.33699601
47MP0005379_endocrine/exocrine_gland_phen1.33045672
48MP0003011_delayed_dark_adaptation1.32466346
49MP0005253_abnormal_eye_physiology1.30151629
50MP0005266_abnormal_metabolism1.29256147
51MP0004019_abnormal_vitamin_homeostasis1.28621340
52MP0005075_abnormal_melanosome_morpholog1.28254231
53MP0002160_abnormal_reproductive_system1.24691701
54MP0001919_abnormal_reproductive_system1.20533351
55MP0004782_abnormal_surfactant_physiolog1.20211499
56MP0001730_embryonic_growth_arrest1.19991261
57MP0006276_abnormal_autonomic_nervous1.19170658
58MP0002210_abnormal_sex_determination1.18225540
59MP0002234_abnormal_pharynx_morphology1.17301264
60MP0000749_muscle_degeneration1.15977550
61MP0004142_abnormal_muscle_tone1.13479279
62MP0002163_abnormal_gland_morphology1.12194181
63MP0001929_abnormal_gametogenesis1.11642103
64MP0003787_abnormal_imprinting1.08329278
65MP0002132_abnormal_respiratory_system1.05930049
66MP0005376_homeostasis/metabolism_phenot1.03707686
67MP0001984_abnormal_olfaction1.03322195
68MP0005319_abnormal_enzyme/_coenzyme1.02889602
69MP0001145_abnormal_male_reproductive1.01283972
70MP0001119_abnormal_female_reproductive0.97213174
71MP0001905_abnormal_dopamine_level0.95241397
72MP0005451_abnormal_body_composition0.95172214
73MP0002837_dystrophic_cardiac_calcinosis0.94820693
74MP0008872_abnormal_physiological_respon0.93134649
75MP0003183_abnormal_peptide_metabolism0.92883274
76MP0002638_abnormal_pupillary_reflex0.92855028
77MP0000631_abnormal_neuroendocrine_gland0.92619710
78MP0000653_abnormal_sex_gland0.92401152
79MP0005636_abnormal_mineral_homeostasis0.90168293
80MP0005645_abnormal_hypothalamus_physiol0.90041155
81MP0005084_abnormal_gallbladder_morpholo0.89688030
82MP0001666_abnormal_nutrient_absorption0.88601560
83MP0002693_abnormal_pancreas_physiology0.88062351
84MP0002877_abnormal_melanocyte_morpholog0.87682851
85MP0002138_abnormal_hepatobiliary_system0.86887569
86MP0005394_taste/olfaction_phenotype0.86154853
87MP0005499_abnormal_olfactory_system0.86154853
88MP0002090_abnormal_vision0.83592316
89MP0004264_abnormal_extraembryonic_tissu0.82274141
90MP0010329_abnormal_lipoprotein_level0.81989985
91MP0001529_abnormal_vocalization0.81643988
92MP0001188_hyperpigmentation0.81517679
93MP0000313_abnormal_cell_death0.80884273
94MP0000358_abnormal_cell_content/0.79939120
95MP0000350_abnormal_cell_proliferation0.79665439
96MP0005551_abnormal_eye_electrophysiolog0.78642447
97MP0004133_heterotaxia0.78609791
98MP0001672_abnormal_embryogenesis/_devel0.77493369
99MP0005380_embryogenesis_phenotype0.77493369
100MP0005220_abnormal_exocrine_pancreas0.77015730
101MP0001727_abnormal_embryo_implantation0.76858152
102MP0001968_abnormal_touch/_nociception0.76671933
103MP0005395_other_phenotype0.76561205
104MP0004147_increased_porphyrin_level0.76325746
105MP0002751_abnormal_autonomic_nervous0.75939309
106MP0003937_abnormal_limbs/digits/tail_de0.75922737
107MP0009046_muscle_twitch0.75837195
108MP0001485_abnormal_pinna_reflex0.75313287
109MP0003137_abnormal_impulse_conducting0.75271561
110MP0010386_abnormal_urinary_bladder0.74551223
111MP0001186_pigmentation_phenotype0.74434303
112MP0000609_abnormal_liver_physiology0.73241759
113MP0009643_abnormal_urine_homeostasis0.72771337
114MP0005391_vision/eye_phenotype0.72325024
115MP0001756_abnormal_urination0.71746025
116MP0002085_abnormal_embryonic_tissue0.70946978
117MP0000598_abnormal_liver_morphology0.70281496
118MP0002084_abnormal_developmental_patter0.69945342
119MP0005410_abnormal_fertilization0.69821201
120MP0003698_abnormal_male_reproductive0.69802786
121MP0003868_abnormal_feces_composition0.69579086
122MP0005646_abnormal_pituitary_gland0.68509548
123MP0002019_abnormal_tumor_incidence0.67930314
124MP0001697_abnormal_embryo_size0.66409320
125MP0002078_abnormal_glucose_homeostasis0.66382521
126MP0003646_muscle_fatigue0.66190802
127MP0003984_embryonic_growth_retardation0.65578853
128MP0000372_irregular_coat_pigmentation0.65234311
129MP0005330_cardiomyopathy0.64800545
130MP0003122_maternal_imprinting0.64739470
131MP0000490_abnormal_crypts_of0.64381249
132MP0000015_abnormal_ear_pigmentation0.63520391
133MP0003567_abnormal_fetal_cardiomyocyte0.63352560
134MP0004043_abnormal_pH_regulation0.62694121
135MP0002088_abnormal_embryonic_growth/wei0.61491075
136MP0002095_abnormal_skin_pigmentation0.60112582
137MP0003315_abnormal_perineum_morphology0.59203713
138MP0002396_abnormal_hematopoietic_system0.58796238
139MP0002080_prenatal_lethality0.58535717
140MP0003959_abnormal_lean_body0.58298314
141MP0009672_abnormal_birth_weight0.57905066
142MP0002277_abnormal_respiratory_mucosa0.55311215

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.50935448
2Acute encephalopathy (HP:0006846)4.11685931
3Abnormal mitochondria in muscle tissue (HP:0008316)4.01461094
4Birth length less than 3rd percentile (HP:0003561)3.71210135
5Progressive macrocephaly (HP:0004481)3.67759690
6Increased CSF lactate (HP:0002490)3.60258590
7Mitochondrial inheritance (HP:0001427)3.59608660
8Cerebral edema (HP:0002181)3.57274397
9Hepatic necrosis (HP:0002605)3.45114917
10Increased hepatocellular lipid droplets (HP:0006565)3.32266732
11Lipid accumulation in hepatocytes (HP:0006561)3.29266079
12Hepatocellular necrosis (HP:0001404)3.22437676
13Type I transferrin isoform profile (HP:0003642)3.13213936
14Increased serum lactate (HP:0002151)3.09803703
15Hypobetalipoproteinemia (HP:0003563)2.97587092
16Microvesicular hepatic steatosis (HP:0001414)2.95373155
17Abnormality of methionine metabolism (HP:0010901)2.95344323
183-Methylglutaconic aciduria (HP:0003535)2.94081407
19Congenital, generalized hypertrichosis (HP:0004540)2.92579330
20Abnormality of serum amino acid levels (HP:0003112)2.87530553
21Lactic acidosis (HP:0003128)2.84324649
22Methylmalonic acidemia (HP:0002912)2.81323407
23Increased muscle lipid content (HP:0009058)2.80459420
24Abnormality of alanine metabolism (HP:0010916)2.79481280
25Hyperalaninemia (HP:0003348)2.79481280
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79481280
27Hyperglycinemia (HP:0002154)2.79190541
28Renal cortical cysts (HP:0000803)2.78800650
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73152487
30Macrocytic anemia (HP:0001972)2.72599209
31Lethargy (HP:0001254)2.69101202
32Reduced antithrombin III activity (HP:0001976)2.68603794
33Hypoglycemic coma (HP:0001325)2.68297329
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66678410
35Aplastic anemia (HP:0001915)2.63163835
36Exercise intolerance (HP:0003546)2.56938397
37Chromsome breakage (HP:0040012)2.54255678
38Abnormality of pyrimidine metabolism (HP:0004353)2.53344335
39Abnormality of cells of the erythroid lineage (HP:0012130)2.53112186
40Abnormal spermatogenesis (HP:0008669)2.47145717
41Abnormal number of erythroid precursors (HP:0012131)2.46976998
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43805889
43Degeneration of anterior horn cells (HP:0002398)2.43683064
44Abnormality of the anterior horn cell (HP:0006802)2.43683064
45Oral leukoplakia (HP:0002745)2.42034184
46Prolonged partial thromboplastin time (HP:0003645)2.42023294
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40983142
48Renal Fanconi syndrome (HP:0001994)2.40261638
49Breast hypoplasia (HP:0003187)2.37887071
50Colon cancer (HP:0003003)2.37729020
51Generalized aminoaciduria (HP:0002909)2.37517497
52Proximal tubulopathy (HP:0000114)2.36775532
53Increased serum pyruvate (HP:0003542)2.36105066
54Abnormality of glycolysis (HP:0004366)2.36105066
55Intrahepatic cholestasis (HP:0001406)2.35668981
56Hyperglycinuria (HP:0003108)2.35255871
57Abnormality of urine glucose concentration (HP:0011016)2.29238981
58Glycosuria (HP:0003076)2.29238981
59Abnormality of the labia minora (HP:0012880)2.27943805
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25364289
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25357380
62Respiratory failure (HP:0002878)2.24389398
63Abnormality of chromosome stability (HP:0003220)2.18338220
6411 pairs of ribs (HP:0000878)2.18313400
65Pancreatic fibrosis (HP:0100732)2.17627260
66CNS demyelination (HP:0007305)2.17436430
67Amniotic constriction ring (HP:0009775)2.16113042
68Abnormality of placental membranes (HP:0011409)2.16113042
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15628215
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15628215
71Impulsivity (HP:0100710)2.05817410
72Optic disc pallor (HP:0000543)2.04989359
73Megaloblastic anemia (HP:0001889)2.04925432
74Abnormality of the preputium (HP:0100587)2.04201145
75X-linked dominant inheritance (HP:0001423)2.03183165
76Pancreatic cysts (HP:0001737)2.02370423
77Pancytopenia (HP:0001876)1.99743627
78Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97396199
79Dicarboxylic aciduria (HP:0003215)1.97396199
80Abnormality of serine family amino acid metabolism (HP:0010894)1.96606765
81Abnormality of glycine metabolism (HP:0010895)1.96606765
82Abnormality of renal resorption (HP:0011038)1.96187300
83Azoospermia (HP:0000027)1.96140359
84Respiratory difficulties (HP:0002880)1.95797118
85Multiple enchondromatosis (HP:0005701)1.94096140
86Leukodystrophy (HP:0002415)1.92247168
87Hyperammonemia (HP:0001987)1.91003386
88Abnormal glycosylation (HP:0012345)1.90130875
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90130875
90Abnormal protein N-linked glycosylation (HP:0012347)1.90130875
91Abnormal protein glycosylation (HP:0012346)1.90130875
92Abnormality of midbrain morphology (HP:0002418)1.89144298
93Molar tooth sign on MRI (HP:0002419)1.89144298
94Conjugated hyperbilirubinemia (HP:0002908)1.89016487
95Nausea (HP:0002018)1.88674074
96Bone marrow hypocellularity (HP:0005528)1.88568845
97Hyperinsulinemic hypoglycemia (HP:0000825)1.88248240
98Rough bone trabeculation (HP:0100670)1.87362254
99Abnormality of vitamin B metabolism (HP:0004340)1.87347142
100Palpitations (HP:0001962)1.85210600
101Abnormality of the renal cortex (HP:0011035)1.83700926
102Premature graying of hair (HP:0002216)1.83683374
103Abnormality of the ileum (HP:0001549)1.83567095
104Type 2 muscle fiber atrophy (HP:0003554)1.83429119
105Abnormal lung lobation (HP:0002101)1.83056964
106Abnormality of the renal collecting system (HP:0004742)1.82280181
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.80795674
108Abnormality of fatty-acid metabolism (HP:0004359)1.80670124
109Reticulocytopenia (HP:0001896)1.79705844
110Methylmalonic aciduria (HP:0012120)1.79537103
111Exertional dyspnea (HP:0002875)1.78685069
112Osteomalacia (HP:0002749)1.77981121
113Cerebral hypomyelination (HP:0006808)1.77622198
114Metabolic acidosis (HP:0001942)1.77580987
115Duplicated collecting system (HP:0000081)1.76950814
116Increased intramyocellular lipid droplets (HP:0012240)1.76824201
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.76562503
118Meckel diverticulum (HP:0002245)1.75433406
119Hyperphosphaturia (HP:0003109)1.74611206
120Medial flaring of the eyebrow (HP:0010747)1.73365170
121Pallor (HP:0000980)1.72387471
122Stenosis of the external auditory canal (HP:0000402)1.72278706
123Abnormality of the pons (HP:0007361)1.71650009
124Neoplasm of the adrenal gland (HP:0100631)1.68526528
125Volvulus (HP:0002580)1.67916749
126Emotional lability (HP:0000712)1.66928213
127Aplasia/hypoplasia of the uterus (HP:0008684)1.66199733
128Hypoplasia of the pons (HP:0012110)1.65695191
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.65360982
130IgM deficiency (HP:0002850)1.64064685
131Pancreatic islet-cell hyperplasia (HP:0004510)1.61794653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.97477145
2EIF2AK13.81158224
3VRK23.68719048
4STK163.34494471
5BUB13.13706249
6ZAK2.95933868
7WEE12.75707215
8PLK42.62311902
9EIF2AK32.48944584
10ACVR1B2.27965482
11BRSK22.22083254
12AKT31.99285344
13IRAK31.98998300
14VRK11.87498538
15CDC71.86129265
16CCNB11.81643828
17BCKDK1.78109503
18MAP4K21.76865732
19PBK1.73031399
20TRIM281.72469645
21TAF11.71657864
22ERBB31.69771914
23TSSK61.62981653
24PLK31.59688835
25NEK11.52170023
26EPHA21.52071299
27BRAF1.49310327
28BMPR21.42166658
29NME21.39675941
30PDK31.36707285
31PDK41.36707285
32PLK11.34423740
33TTK1.33699865
34MKNK11.33442371
35BMPR1B1.27146899
36STK38L1.26960611
37TLK11.24069571
38WNK31.22054674
39CSNK1G11.20879466
40NEK91.18422955
41PNCK1.17869686
42BRSK11.17300309
43EIF2AK21.17076509
44NME11.16969357
45CSNK1G31.16869593
46INSRR1.15620752
47TNIK1.15331708
48MST41.14686182
49NEK21.12168902
50CSNK1G21.07009460
51ATR1.06114453
52NUAK11.05475351
53MKNK21.04143310
54AURKB1.02981940
55PASK1.01536043
56IRAK41.00874580
57CHEK21.00233712
58AURKA0.98185824
59PIK3CG0.96390813
60PDK20.95432763
61CDK80.93496504
62GRK10.90368524
63DYRK30.90098154
64SCYL20.88863430
65BCR0.87938763
66MAPK150.86998397
67OBSCN0.83220515
68PINK10.82461459
69STK240.82319171
70CSNK1A1L0.80425085
71PIM20.80383854
72MELK0.79091309
73CDK70.75263085
74SIK30.74191837
75FLT30.72323842
76IRAK10.72226491
77YES10.71986050
78PLK20.71723809
79MAP3K140.71234399
80CSNK2A10.70683502
81OXSR10.68222261
82RPS6KB20.63946216
83TEC0.62383097
84STK390.62285804
85RPS6KA50.61715720
86ATM0.61692527
87MINK10.61583771
88PHKG20.61458121
89PHKG10.61458121
90ARAF0.60964109
91DYRK20.60222998
92RPS6KB10.59955275
93PRKCI0.59924183
94CSNK2A20.59596359
95GRK70.59396149
96ADRBK20.59053976
97DAPK10.58123497
98MYLK0.56147836
99FRK0.55989797
100TXK0.55055986
101MAP3K40.54934322
102TIE10.54385290
103NEK60.53878497
104TGFBR10.53254509
105CSNK1E0.52841550
106CHEK10.52771458
107ALK0.52701165
108PAK30.52318286
109PRKCG0.49246835
110LIMK10.48854907
111TESK10.47007350
112PIM10.45726812
113PRKCE0.43136841
114ABL20.42399806
115STK40.41246733
116WNK40.39175822
117MAPK130.36443644
118MAP2K70.35961155
119NLK0.33759243
120CSNK1A10.33518452
121CASK0.33222217
122SGK20.33099667
123CDK20.32810208
124ERBB40.32454682
125PAK40.30824898
126MAPKAPK50.30561545
127CDK30.30024826
128CDK10.29656587
129PRKDC0.28953937
130MAP3K50.28225798
131RPS6KA40.27369079
132MAP3K120.26234647
133RPS6KC10.22856122

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98578680
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88563913
3RNA polymerase_Homo sapiens_hsa030202.85141569
4Protein export_Homo sapiens_hsa030602.76407494
5DNA replication_Homo sapiens_hsa030302.71293636
6Mismatch repair_Homo sapiens_hsa034302.65541792
7Homologous recombination_Homo sapiens_hsa034402.36524762
8* Ribosome_Homo sapiens_hsa030102.18317800
9Pyrimidine metabolism_Homo sapiens_hsa002402.15420007
10Nucleotide excision repair_Homo sapiens_hsa034202.11315148
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10654022
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10507719
13Oxidative phosphorylation_Homo sapiens_hsa001902.04722322
14One carbon pool by folate_Homo sapiens_hsa006702.04602261
15RNA transport_Homo sapiens_hsa030131.98140322
16Spliceosome_Homo sapiens_hsa030401.92210634
17Basal transcription factors_Homo sapiens_hsa030221.79800313
18Parkinsons disease_Homo sapiens_hsa050121.79408955
19Non-homologous end-joining_Homo sapiens_hsa034501.75719518
20Base excision repair_Homo sapiens_hsa034101.72499868
21Fanconi anemia pathway_Homo sapiens_hsa034601.66693640
22Cardiac muscle contraction_Homo sapiens_hsa042601.60993059
23RNA degradation_Homo sapiens_hsa030181.60698259
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60412540
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.57154344
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55139399
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54328973
28Propanoate metabolism_Homo sapiens_hsa006401.52720293
29Huntingtons disease_Homo sapiens_hsa050161.49505337
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49172841
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.46931672
32Selenocompound metabolism_Homo sapiens_hsa004501.44252940
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.39027787
34Vitamin B6 metabolism_Homo sapiens_hsa007501.33823401
35Purine metabolism_Homo sapiens_hsa002301.31077281
36Cell cycle_Homo sapiens_hsa041101.30555679
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30003064
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.29053122
39Peroxisome_Homo sapiens_hsa041461.28358666
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25297257
41Folate biosynthesis_Homo sapiens_hsa007901.23784030
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18141585
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15712677
44Sulfur metabolism_Homo sapiens_hsa009201.15030250
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10930877
46Alzheimers disease_Homo sapiens_hsa050101.09635289
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08878036
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07024444
49Pyruvate metabolism_Homo sapiens_hsa006201.05824255
50Carbon metabolism_Homo sapiens_hsa012001.05725043
51Glutathione metabolism_Homo sapiens_hsa004801.05677364
52Fatty acid degradation_Homo sapiens_hsa000711.04454790
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98031308
54Tryptophan metabolism_Homo sapiens_hsa003800.96159867
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95525348
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91298117
57mRNA surveillance pathway_Homo sapiens_hsa030150.87625285
58beta-Alanine metabolism_Homo sapiens_hsa004100.85665755
59Pentose phosphate pathway_Homo sapiens_hsa000300.84035682
60Metabolic pathways_Homo sapiens_hsa011000.83946806
61Phenylalanine metabolism_Homo sapiens_hsa003600.82622391
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81882996
63Tyrosine metabolism_Homo sapiens_hsa003500.79869958
64Biosynthesis of amino acids_Homo sapiens_hsa012300.79575021
65Chemical carcinogenesis_Homo sapiens_hsa052040.78641046
66Fatty acid elongation_Homo sapiens_hsa000620.78471719
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77719928
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74692174
69Systemic lupus erythematosus_Homo sapiens_hsa053220.74427240
70Arginine and proline metabolism_Homo sapiens_hsa003300.74096352
71Oocyte meiosis_Homo sapiens_hsa041140.72979720
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.72875468
73Regulation of autophagy_Homo sapiens_hsa041400.72130646
74Arachidonic acid metabolism_Homo sapiens_hsa005900.70181101
75Histidine metabolism_Homo sapiens_hsa003400.69863174
76Retinol metabolism_Homo sapiens_hsa008300.68198643
77Arginine biosynthesis_Homo sapiens_hsa002200.66205952
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65842682
79Caffeine metabolism_Homo sapiens_hsa002320.62499769
80Starch and sucrose metabolism_Homo sapiens_hsa005000.62259509
81Butanoate metabolism_Homo sapiens_hsa006500.58685404
82p53 signaling pathway_Homo sapiens_hsa041150.58582560
83Complement and coagulation cascades_Homo sapiens_hsa046100.57479161
84Collecting duct acid secretion_Homo sapiens_hsa049660.56571749
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56431909
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55417357
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52906105
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52024858
89Fructose and mannose metabolism_Homo sapiens_hsa000510.51654009
90Linoleic acid metabolism_Homo sapiens_hsa005910.51487135
91Epstein-Barr virus infection_Homo sapiens_hsa051690.50834088
92Sulfur relay system_Homo sapiens_hsa041220.50005751
93Galactose metabolism_Homo sapiens_hsa000520.48755721
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48042331
95Steroid biosynthesis_Homo sapiens_hsa001000.47336071
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45659890
97Fatty acid metabolism_Homo sapiens_hsa012120.44622659
98N-Glycan biosynthesis_Homo sapiens_hsa005100.43357959
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.43140254
100Legionellosis_Homo sapiens_hsa051340.42005643
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40687088
102Phototransduction_Homo sapiens_hsa047440.38661380
103Antigen processing and presentation_Homo sapiens_hsa046120.34312173
104Nitrogen metabolism_Homo sapiens_hsa009100.33931036
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33031924
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31854263
107Type I diabetes mellitus_Homo sapiens_hsa049400.30168772
108Vitamin digestion and absorption_Homo sapiens_hsa049770.26833122
109Circadian rhythm_Homo sapiens_hsa047100.20140944
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12574276
111Asthma_Homo sapiens_hsa053100.11218694
112Olfactory transduction_Homo sapiens_hsa047400.10941548
113TGF-beta signaling pathway_Homo sapiens_hsa043500.10127695
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09230740
115Nicotine addiction_Homo sapiens_hsa050330.08894558

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