MRPL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.11563643
2protein localization to kinetochore (GO:0034501)5.81557968
3regulation of mammary gland epithelial cell proliferation (GO:0033599)5.41738269
4maintenance of protein location in nucleus (GO:0051457)5.20113663
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.14998200
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.06938877
7rRNA methylation (GO:0031167)5.00938705
8rRNA transcription (GO:0009303)4.97676663
9negative regulation of telomerase activity (GO:0051974)4.96083276
10somite rostral/caudal axis specification (GO:0032525)4.92852269
11rRNA modification (GO:0000154)4.91106472
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.73977932
13negative regulation of epidermis development (GO:0045683)4.69119796
14negative regulation of cell cycle G2/M phase transition (GO:1902750)4.67005168
15regulation of telomere maintenance via telomerase (GO:0032210)4.66924009
16coenzyme catabolic process (GO:0009109)4.63919849
17muscle organ morphogenesis (GO:0048644)4.61133089
18quinone metabolic process (GO:1901661)4.60588883
19mitotic sister chromatid segregation (GO:0000070)4.59963907
20ribosomal small subunit assembly (GO:0000028)4.54856386
21proteasome assembly (GO:0043248)4.43211337
22cytidine metabolic process (GO:0046087)4.42189930
23cytidine catabolic process (GO:0006216)4.42189930
24cytidine deamination (GO:0009972)4.42189930
25regulation of response to osmotic stress (GO:0047484)4.39631849
26DNA replication-dependent nucleosome assembly (GO:0006335)4.37530152
27DNA replication-dependent nucleosome organization (GO:0034723)4.37530152
28cullin deneddylation (GO:0010388)4.35845590
29protein localization to chromosome, centromeric region (GO:0071459)4.20012292
30regulation of translation in response to stress (GO:0043555)4.19734611
31nucleoside transmembrane transport (GO:1901642)4.14568061
32histone H4-K12 acetylation (GO:0043983)4.13904036
33regulation of MHC class I biosynthetic process (GO:0045343)4.09759818
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07754607
35cellular modified amino acid catabolic process (GO:0042219)4.04493202
36histone H4-K5 acetylation (GO:0043981)4.01453452
37histone H4-K8 acetylation (GO:0043982)4.01453452
38protein deneddylation (GO:0000338)4.00351721
39DNA replication checkpoint (GO:0000076)3.97237089
40hormone catabolic process (GO:0042447)3.97013206
41regulation of mitochondrial translation (GO:0070129)3.91916156
42GDP-mannose metabolic process (GO:0019673)3.91119922
43formation of translation preinitiation complex (GO:0001731)3.87384937
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.84550975
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83190096
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78519805
47maturation of SSU-rRNA (GO:0030490)3.76923194
48transcription from mitochondrial promoter (GO:0006390)3.76868656
49viral transcription (GO:0019083)3.76342498
50sulfur amino acid catabolic process (GO:0000098)3.74942917
51negative regulation of ligase activity (GO:0051352)3.74851452
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.74851452
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73650395
54regulation of cilium movement (GO:0003352)3.72923042
55interferon-gamma production (GO:0032609)3.72796944
56pteridine-containing compound biosynthetic process (GO:0042559)3.72729229
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72558978
58negative regulation of telomere maintenance (GO:0032205)3.71975950
59L-serine metabolic process (GO:0006563)3.71797489
60ribosomal large subunit biogenesis (GO:0042273)3.70602088
61DNA strand elongation involved in DNA replication (GO:0006271)3.70295379
62ribosome assembly (GO:0042255)3.69044737
63translational termination (GO:0006415)3.67271636
64establishment of integrated proviral latency (GO:0075713)3.65580402
65positive regulation of DNA-dependent DNA replication (GO:2000105)3.64361420
66chaperone-mediated protein transport (GO:0072321)3.63251413
67notochord development (GO:0030903)3.60072755
68negative regulation of epidermal cell differentiation (GO:0045605)3.58428154
69heterochromatin organization (GO:0070828)3.58275622
70response to dietary excess (GO:0002021)3.55973255
71DNA strand elongation (GO:0022616)3.55528631
72translational elongation (GO:0006414)3.54896776
73sister chromatid segregation (GO:0000819)3.54194596
74telomere maintenance via semi-conservative replication (GO:0032201)3.53083239
75pseudouridine synthesis (GO:0001522)3.50726814
76phenol-containing compound catabolic process (GO:0019336)3.50185178
77ATP synthesis coupled proton transport (GO:0015986)3.47595567
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47595567
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.46873693
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.43723076
81oxidative phosphorylation (GO:0006119)3.43711132
82IMP biosynthetic process (GO:0006188)3.43504434
83epoxygenase P450 pathway (GO:0019373)3.42844336
84purine nucleobase biosynthetic process (GO:0009113)3.42427049
85translational initiation (GO:0006413)3.41766708
86* ribonucleoprotein complex biogenesis (GO:0022613)3.40813986
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40376045
88maternal placenta development (GO:0001893)3.40190489
89regulation of cellular amino acid metabolic process (GO:0006521)3.39837026
90cotranslational protein targeting to membrane (GO:0006613)3.39589115
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39235164
92biotin metabolic process (GO:0006768)3.38540049
93tRNA aminoacylation for protein translation (GO:0006418)3.38101609
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37033250
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37033250
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37033250
97pyrimidine ribonucleoside catabolic process (GO:0046133)3.36514226
98protein targeting to ER (GO:0045047)3.36081399
99protein targeting to mitochondrion (GO:0006626)3.35765730
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35102190
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35102190
102* translation (GO:0006412)3.29750726
103signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28982719
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.28982719
105amino acid activation (GO:0043038)3.26747714
106tRNA aminoacylation (GO:0043039)3.26747714
107mitochondrial DNA replication (GO:0006264)3.26096139
108maintenance of protein localization in organelle (GO:0072595)3.26083513
109positive regulation of ligase activity (GO:0051351)3.25855399
110signal transduction involved in cell cycle checkpoint (GO:0072395)3.25238928
111peptidyl-arginine omega-N-methylation (GO:0035247)3.24983441
112establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22967290
113protein localization to endoplasmic reticulum (GO:0070972)3.22077429
114nucleobase biosynthetic process (GO:0046112)3.21264158
115primary alcohol catabolic process (GO:0034310)3.20816427
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20615225
117primitive streak formation (GO:0090009)3.18706510
118cofactor transport (GO:0051181)3.17364337
119regulation of ubiquitin-protein transferase activity (GO:0051438)3.16228465
120* cellular component biogenesis (GO:0044085)3.14900236
121histone arginine methylation (GO:0034969)3.14705614
122mitochondrial RNA metabolic process (GO:0000959)3.11287578
123chromatin assembly (GO:0031497)3.10657373
124regulation of telomerase activity (GO:0051972)3.10456042
125transcription elongation from RNA polymerase III promoter (GO:0006385)3.10394308
126termination of RNA polymerase III transcription (GO:0006386)3.10394308
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08366616
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08366616
129establishment of protein localization to mitochondrion (GO:0072655)3.07600295
130intestinal epithelial cell development (GO:0060576)3.06901505
131regulation of ligase activity (GO:0051340)3.05924492
132* ribosome biogenesis (GO:0042254)3.05871785
133rRNA processing (GO:0006364)3.03574661
134viral life cycle (GO:0019058)3.03454181
135spliceosomal snRNP assembly (GO:0000387)3.02983532
136branching involved in mammary gland duct morphogenesis (GO:0060444)3.02090768
137mitotic metaphase plate congression (GO:0007080)2.99993157
138nucleoside transport (GO:0015858)2.99519116
139ribosomal small subunit biogenesis (GO:0042274)2.96556978
140intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.95649061
141folic acid-containing compound biosynthetic process (GO:0009396)2.95140437
142branched-chain amino acid catabolic process (GO:0009083)2.94998514
143regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.94956432
144establishment of viral latency (GO:0019043)2.94573436
145chromatin remodeling at centromere (GO:0031055)2.94558821
146peptidyl-histidine modification (GO:0018202)2.94392175
147DNA damage response, detection of DNA damage (GO:0042769)2.94391683
148GMP metabolic process (GO:0046037)2.93625282
149protein localization to mitochondrion (GO:0070585)2.93178259
150valine metabolic process (GO:0006573)2.91371690
151guanosine-containing compound biosynthetic process (GO:1901070)2.90848444
152IMP metabolic process (GO:0046040)2.90625174
153base-excision repair (GO:0006284)2.89783710
154cofactor catabolic process (GO:0051187)2.89716309
155regulation of posttranscriptional gene silencing (GO:0060147)2.89666159
156regulation of gene silencing by miRNA (GO:0060964)2.89666159
157regulation of gene silencing by RNA (GO:0060966)2.89666159
158regulation of translational fidelity (GO:0006450)2.86627384
159rRNA metabolic process (GO:0016072)2.86306904
160CENP-A containing nucleosome assembly (GO:0034080)2.86191476
161L-ascorbic acid metabolic process (GO:0019852)2.85965415
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85939290
163DNA replication initiation (GO:0006270)2.85902777
164transcription-coupled nucleotide-excision repair (GO:0006283)2.85882314
165peptidyl-arginine methylation (GO:0018216)2.84771889
166peptidyl-arginine N-methylation (GO:0035246)2.84771889
167serine family amino acid biosynthetic process (GO:0009070)2.84631819
168mitochondrial DNA metabolic process (GO:0032042)2.83854584
169cellular protein complex disassembly (GO:0043624)2.79692442
170respiratory electron transport chain (GO:0022904)2.79355108
171telomere maintenance via recombination (GO:0000722)2.78174367
172retinoic acid receptor signaling pathway (GO:0048384)2.77953864
173heme transport (GO:0015886)2.76766310
174intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.72892631
175positive regulation of protein deacetylation (GO:0090312)2.72629464
176cardiovascular system development (GO:0072358)2.68613006
177regulation of G0 to G1 transition (GO:0070316)2.67288650
178apoptotic DNA fragmentation (GO:0006309)2.67262596
179cell fate commitment involved in formation of primary germ layer (GO:0060795)2.67210551
180nuclear pore complex assembly (GO:0051292)2.66438599
181phagocytosis, recognition (GO:0006910)2.64842570
182cellular ketone metabolic process (GO:0042180)2.64672253
183negative regulation of gene silencing (GO:0060969)2.64426281
184signal transduction involved in regulation of gene expression (GO:0023019)2.64418703
185histone H4-K16 acetylation (GO:0043984)2.62043808
186daunorubicin metabolic process (GO:0044597)10.3664435
187polyketide metabolic process (GO:0030638)10.3664435
188doxorubicin metabolic process (GO:0044598)10.3664435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.61624732
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.54106582
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.54106582
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.54106582
5E2F7_22180533_ChIP-Seq_HELA_Human4.30368926
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.30139482
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36433942
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.79070727
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73725496
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73482978
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57709042
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.51741691
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28121939
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.23585815
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19384031
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16815340
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16780309
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10357129
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06268679
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.04210682
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02938906
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02344149
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01212171
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00644613
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98918091
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98782818
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95568059
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95498117
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.95309904
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.90331133
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.84434491
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84292643
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83975784
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80625542
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.80458309
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77942625
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.74983787
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71554605
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70053384
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68582414
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66417071
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65807777
43* ETS1_20019798_ChIP-Seq_JURKAT_Human1.63794926
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63043562
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62115107
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59554339
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55033046
48ELK1_19687146_ChIP-ChIP_HELA_Human1.53923255
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50341098
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49665352
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.47898101
52IRF1_19129219_ChIP-ChIP_H3396_Human1.40661719
53OCT4_18692474_ChIP-Seq_MEFs_Mouse1.38756887
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38221151
55FOXP3_21729870_ChIP-Seq_TREG_Human1.37846338
56* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36162927
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35009862
58* XRN2_22483619_ChIP-Seq_HELA_Human1.32319634
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31903645
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30577955
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29823933
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28205055
63SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27822436
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27605805
65MYC_22102868_ChIP-Seq_BL_Human1.26800812
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26316314
67* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26098338
68NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26083692
69* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24118790
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23236081
71GABP_19822575_ChIP-Seq_HepG2_Human1.22085959
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21696409
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19435301
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18459211
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17375507
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17193848
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17040030
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16965947
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15106218
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12622118
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12605259
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10202681
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.10165703
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10032884
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09942809
86* VDR_23849224_ChIP-Seq_CD4+_Human1.09488983
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08994782
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07964703
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06835536
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06734005
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06124475
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05486669
93KDM5A_27292631_Chip-Seq_BREAST_Human1.05009772
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.04821655
95NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04526335
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04196806
97ZNF263_19887448_ChIP-Seq_K562_Human1.03764707
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03519726
99DCP1A_22483619_ChIP-Seq_HELA_Human1.03414693
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01800198
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00021921
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99978347
103SRF_21415370_ChIP-Seq_HL-1_Mouse0.99109442
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97270131
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97072565
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96412234
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96310228
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95334356
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95306881
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94635088
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93806532
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93248492
113TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92807368
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92783776
115MYC_18940864_ChIP-ChIP_HL60_Human0.91841167
116TTF2_22483619_ChIP-Seq_HELA_Human0.90003180
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.89927765
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89711213
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.89692443
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89520523
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.89277902
122* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88908433
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85405655
124CIITA_25753668_ChIP-Seq_RAJI_Human0.85387641
125AR_21909140_ChIP-Seq_LNCAP_Human0.85015412
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.84975292
127NANOG_16518401_ChIP-PET_MESCs_Mouse0.83540038
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83290933
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82375805
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82008226
131* SOX17_20123909_ChIP-Seq_XEN_Mouse0.81688172
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81439029
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81363241
134* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81350951
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80050267
136TFEB_21752829_ChIP-Seq_HELA_Human0.79609551
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79037335
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.78829038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.25398840
2MP0003011_delayed_dark_adaptation4.15590838
3MP0006292_abnormal_olfactory_placode3.64613117
4MP0004957_abnormal_blastocyst_morpholog3.43319878
5MP0002254_reproductive_system_inflammat3.18188364
6MP0006035_abnormal_mitochondrial_morpho3.07768701
7MP0005075_abnormal_melanosome_morpholog2.96481696
8MP0003890_abnormal_embryonic-extraembry2.93648288
9MP0003806_abnormal_nucleotide_metabolis2.82877481
10MP0008057_abnormal_DNA_replication2.82363023
11MP0002332_abnormal_exercise_endurance2.80372506
12MP0005394_taste/olfaction_phenotype2.53204496
13MP0005499_abnormal_olfactory_system2.53204496
14MP0004858_abnormal_nervous_system2.34903568
15MP0003122_maternal_imprinting2.31579658
16MP0003718_maternal_effect2.20988041
17MP0003705_abnormal_hypodermis_morpholog2.20145659
18MP0010352_gastrointestinal_tract_polyps2.11422482
19MP0000678_abnormal_parathyroid_gland2.03132937
20MP0003186_abnormal_redox_activity1.97227063
21MP0003567_abnormal_fetal_cardiomyocyte1.94950032
22MP0005266_abnormal_metabolism1.94741998
23MP0003136_yellow_coat_color1.90279868
24MP0001661_extended_life_span1.84187889
25MP0004233_abnormal_muscle_weight1.82685399
26MP0005257_abnormal_intraocular_pressure1.82432473
27MP0003077_abnormal_cell_cycle1.82347822
28MP0002653_abnormal_ependyma_morphology1.81239093
29MP0006036_abnormal_mitochondrial_physio1.81029101
30MP0008877_abnormal_DNA_methylation1.80907842
31MP0001672_abnormal_embryogenesis/_devel1.78443251
32MP0005380_embryogenesis_phenotype1.78443251
33MP0003123_paternal_imprinting1.77399012
34MP0003693_abnormal_embryo_hatching1.75306652
35MP0001529_abnormal_vocalization1.74350700
36MP0008995_early_reproductive_senescence1.68469133
37MP0003111_abnormal_nucleus_morphology1.68131728
38MP0009697_abnormal_copulation1.67067974
39MP0003183_abnormal_peptide_metabolism1.66233855
40MP0002088_abnormal_embryonic_growth/wei1.64580095
41MP0003984_embryonic_growth_retardation1.64000260
42MP0009672_abnormal_birth_weight1.61895297
43MP0002938_white_spotting1.61767313
44MP0003121_genomic_imprinting1.59261586
45MP0004043_abnormal_pH_regulation1.57254338
46MP0002127_abnormal_cardiovascular_syste1.55470814
47MP0002139_abnormal_hepatobiliary_system1.53191660
48MP0005319_abnormal_enzyme/_coenzyme1.43466606
49MP0000350_abnormal_cell_proliferation1.43100480
50MP0000372_irregular_coat_pigmentation1.42705937
51MP0002210_abnormal_sex_determination1.42704776
52MP0006082_CNS_inflammation1.41114346
53MP0010030_abnormal_orbit_morphology1.39570601
54MP0002163_abnormal_gland_morphology1.37581675
55MP0005365_abnormal_bile_salt1.32750273
56MP0002132_abnormal_respiratory_system1.30258477
57MP0000358_abnormal_cell_content/1.28353165
58MP0010094_abnormal_chromosome_stability1.28005759
59MP0003646_muscle_fatigue1.26142280
60MP0002970_abnormal_white_adipose1.25876769
61MP0001293_anophthalmia1.23184241
62MP0002269_muscular_atrophy1.21598419
63MP0001145_abnormal_male_reproductive1.20227139
64MP0002086_abnormal_extraembryonic_tissu1.19949311
65MP0000749_muscle_degeneration1.19700428
66MP0008875_abnormal_xenobiotic_pharmacok1.19435660
67MP0002396_abnormal_hematopoietic_system1.18815386
68MP0005360_urolithiasis1.17860745
69MP0001929_abnormal_gametogenesis1.17603887
70MP0000490_abnormal_crypts_of1.17090570
71MP0001764_abnormal_homeostasis1.15950804
72MP0003942_abnormal_urinary_system1.15610421
73MP0003941_abnormal_skin_development1.13854141
74MP0001849_ear_inflammation1.13158859
75MP0008932_abnormal_embryonic_tissue1.11025781
76MP0001730_embryonic_growth_arrest1.10246140
77MP0005085_abnormal_gallbladder_physiolo1.08808381
78MP0000653_abnormal_sex_gland1.08282293
79MP0000313_abnormal_cell_death1.08149130
80MP0008961_abnormal_basal_metabolism1.08096430
81MP0003878_abnormal_ear_physiology1.07709343
82MP0005377_hearing/vestibular/ear_phenot1.07709343
83MP0002085_abnormal_embryonic_tissue1.07340998
84MP0000750_abnormal_muscle_regeneration1.06686192
85MP0008007_abnormal_cellular_replicative1.04382373
86MP0002932_abnormal_joint_morphology1.03241448
87MP0002277_abnormal_respiratory_mucosa1.01963916
88MP0003937_abnormal_limbs/digits/tail_de1.00197229
89MP0004133_heterotaxia1.00126663
90MP0005376_homeostasis/metabolism_phenot0.97670745
91MP0002092_abnormal_eye_morphology0.97533366
92MP0005367_renal/urinary_system_phenotyp0.96999396
93MP0000516_abnormal_urinary_system0.96999396
94MP0000609_abnormal_liver_physiology0.96647089
95MP0002080_prenatal_lethality0.96251441
96MP0002160_abnormal_reproductive_system0.95979280
97MP0001697_abnormal_embryo_size0.95322691
98MP0002697_abnormal_eye_size0.94381755
99MP0004147_increased_porphyrin_level0.94286672
100MP0003698_abnormal_male_reproductive0.92114547
101MP0001286_abnormal_eye_development0.90914656
102MP0008260_abnormal_autophagy0.89428161
103MP0001727_abnormal_embryo_implantation0.89312586
104MP0005670_abnormal_white_adipose0.89169902
105MP0003938_abnormal_ear_development0.87987715
106MP0002102_abnormal_ear_morphology0.87855297
107MP0005379_endocrine/exocrine_gland_phen0.86704096
108MP0002084_abnormal_developmental_patter0.85133077
109MP0001346_abnormal_lacrimal_gland0.84433622
110MP0008789_abnormal_olfactory_epithelium0.83961824
111MP0004197_abnormal_fetal_growth/weight/0.81710083
112MP0005332_abnormal_amino_acid0.81447383
113MP0003119_abnormal_digestive_system0.80841741
114MP0000858_altered_metastatic_potential0.80459254
115MP0005023_abnormal_wound_healing0.79992367
116MP0001119_abnormal_female_reproductive0.79278389
117MP0002161_abnormal_fertility/fecundity0.79040620
118MP0000598_abnormal_liver_morphology0.78783728
119MP0005501_abnormal_skin_physiology0.78213075
120MP0009379_abnormal_foot_pigmentation0.77699647
121MP0000343_altered_response_to0.77289313
122MP0000049_abnormal_middle_ear0.77213310
123MP0003315_abnormal_perineum_morphology0.76674508
124MP0000762_abnormal_tongue_morphology0.76189186
125MP0000537_abnormal_urethra_morphology0.74632798
126MP0005410_abnormal_fertilization0.74482250
127MP0002019_abnormal_tumor_incidence0.73962109
128MP0003137_abnormal_impulse_conducting0.72933913
129MP0001348_abnormal_lacrimal_gland0.72130593
130MP0002111_abnormal_tail_morphology0.71502527
131MP0008770_decreased_survivor_rate0.70821264
132MP0003786_premature_aging0.70492636
133MP0009703_decreased_birth_body0.69196204
134MP0004381_abnormal_hair_follicle0.68983108
135MP0003283_abnormal_digestive_organ0.68443583
136MP0005330_cardiomyopathy0.68086885
137MP0002233_abnormal_nose_morphology0.68052580
138MP0009643_abnormal_urine_homeostasis0.65366656
139MP0009840_abnormal_foam_cell0.64718254
140MP0002114_abnormal_axial_skeleton0.64709679
141MP0002736_abnormal_nociception_after0.64651124
142MP0005384_cellular_phenotype0.64022360
143MP0002877_abnormal_melanocyte_morpholog0.63987861
144MP0008058_abnormal_DNA_repair0.63423218
145MP0009333_abnormal_splenocyte_physiolog0.61872689
146MP0002638_abnormal_pupillary_reflex0.61273149
147MP0003221_abnormal_cardiomyocyte_apopto0.61012827
148MP0003699_abnormal_female_reproductive0.60221043

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.21941007
2Multiple enchondromatosis (HP:0005701)6.11823728
3Hypochromic microcytic anemia (HP:0004840)5.72396856
4Hepatoblastoma (HP:0002884)4.56179036
5Abnormality of the lower motor neuron (HP:0002366)4.50379225
6Reticulocytopenia (HP:0001896)4.38775417
7Ragged-red muscle fibers (HP:0003200)4.08304892
8Ependymoma (HP:0002888)4.04363921
9Rib fusion (HP:0000902)3.93792870
10Hyperinsulinemic hypoglycemia (HP:0000825)3.90403822
11Abnormal mitochondria in muscle tissue (HP:0008316)3.84309417
12Testicular atrophy (HP:0000029)3.77612042
13Acute necrotizing encephalopathy (HP:0006965)3.76298928
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63284100
15Abnormal cartilage morphology (HP:0002763)3.58889068
16Acute encephalopathy (HP:0006846)3.55107218
17Increased CSF lactate (HP:0002490)3.39035992
18Rhabdomyosarcoma (HP:0002859)3.38488005
19Reduced antithrombin III activity (HP:0001976)3.37618783
20Mitochondrial inheritance (HP:0001427)3.36849508
21Increased hepatocellular lipid droplets (HP:0006565)3.35705857
22Neoplasm of striated muscle (HP:0009728)3.22108936
23Trismus (HP:0000211)3.21868323
24Aplasia/Hypoplasia of the fovea (HP:0008060)3.20896629
25Hypoplasia of the fovea (HP:0007750)3.20896629
26Hepatocellular necrosis (HP:0001404)3.20367191
27Microvesicular hepatic steatosis (HP:0001414)3.17794411
28Progressive muscle weakness (HP:0003323)3.15249214
29Increased intramyocellular lipid droplets (HP:0012240)3.14736681
30Chromsome breakage (HP:0040012)3.10305381
31Hyperglycinemia (HP:0002154)3.09187417
32Cerebral hypomyelination (HP:0006808)3.07572820
33Lipid accumulation in hepatocytes (HP:0006561)3.05553444
34Increased serum lactate (HP:0002151)3.02950991
35Abnormality of cells of the erythroid lineage (HP:0012130)3.00895309
36Macrocytic anemia (HP:0001972)3.00826281
37Hepatic necrosis (HP:0002605)2.99247376
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98578771
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98578771
403-Methylglutaconic aciduria (HP:0003535)2.96488503
41Hyperglycinuria (HP:0003108)2.94947526
42Nephroblastoma (Wilms tumor) (HP:0002667)2.91141441
43Abnormal gallbladder physiology (HP:0012438)2.89042177
44Cholecystitis (HP:0001082)2.89042177
45Rectal fistula (HP:0100590)2.88972154
46Rectovaginal fistula (HP:0000143)2.88972154
47Abnormality of glycolysis (HP:0004366)2.83454768
48Increased serum pyruvate (HP:0003542)2.83454768
49Amyotrophic lateral sclerosis (HP:0007354)2.83389127
50Lactic acidosis (HP:0003128)2.82942944
51Abnormal number of erythroid precursors (HP:0012131)2.82664449
52Abnormality of methionine metabolism (HP:0010901)2.80152635
53Abnormality of the intrinsic pathway (HP:0010989)2.80027623
54Progressive macrocephaly (HP:0004481)2.75935690
55Fused cervical vertebrae (HP:0002949)2.75191688
56Abnormality of serum amino acid levels (HP:0003112)2.74856844
57Vaginal fistula (HP:0004320)2.71469437
58Increased muscle lipid content (HP:0009058)2.71312318
59Abnormality of the salivary glands (HP:0010286)2.67565802
60Aplasia/hypoplasia of the humerus (HP:0006507)2.66681312
61Renal Fanconi syndrome (HP:0001994)2.66084432
62Embryonal renal neoplasm (HP:0011794)2.65616936
63Exercise intolerance (HP:0003546)2.62246209
64Cerebral edema (HP:0002181)2.61844964
65Progressive external ophthalmoplegia (HP:0000590)2.57745317
66Abnormal lung lobation (HP:0002101)2.57634509
67Hypochromic anemia (HP:0001931)2.55361536
68Respiratory difficulties (HP:0002880)2.49213703
69Anomalous pulmonary venous return (HP:0010772)2.48865555
70Abnormality of the astrocytes (HP:0100707)2.48574413
71Astrocytoma (HP:0009592)2.48574413
72Short humerus (HP:0005792)2.48360625
73Methylmalonic aciduria (HP:0012120)2.48200609
74Abnormality of homocysteine metabolism (HP:0010919)2.46283372
75Homocystinuria (HP:0002156)2.46283372
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46183391
77Partial duplication of thumb phalanx (HP:0009944)2.43334439
78Abnormality of the labia minora (HP:0012880)2.42792986
79Tongue fasciculations (HP:0001308)2.42542892
80Abnormality of the fovea (HP:0000493)2.41135052
81Type I transferrin isoform profile (HP:0003642)2.40794130
82CNS hypomyelination (HP:0003429)2.40466603
83Intestinal fistula (HP:0100819)2.39023186
84Hyperventilation (HP:0002883)2.38034519
85Meckel diverticulum (HP:0002245)2.36417162
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34862080
87Abnormal protein N-linked glycosylation (HP:0012347)2.34862080
88Abnormal protein glycosylation (HP:0012346)2.34862080
89Abnormal glycosylation (HP:0012345)2.34862080
90Upper motor neuron abnormality (HP:0002127)2.33155248
91Microretrognathia (HP:0000308)2.32719102
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.29813804
93Birth length less than 3rd percentile (HP:0003561)2.29272938
94Horseshoe kidney (HP:0000085)2.27609394
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26275497
96Abnormality of alanine metabolism (HP:0010916)2.26275497
97Hyperalaninemia (HP:0003348)2.26275497
98Muscle fibrillation (HP:0010546)2.25852115
99Combined immunodeficiency (HP:0005387)2.25382231
100Malnutrition (HP:0004395)2.25364350
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.25125643
102Gout (HP:0001997)2.24693648
103Abnormality of liposaccharide metabolism (HP:0010968)2.24502350
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.24502350
105Abnormality of glycolipid metabolism (HP:0010969)2.24502350
106Abnormality of glycine metabolism (HP:0010895)2.24001935
107Abnormality of serine family amino acid metabolism (HP:0010894)2.24001935
108Horizontal nystagmus (HP:0000666)2.23793601
109Bifid tongue (HP:0010297)2.22807600
110Premature ovarian failure (HP:0008209)2.22490436
111Spastic paraparesis (HP:0002313)2.20621472
112Abnormality of the ileum (HP:0001549)2.19720389
113Colon cancer (HP:0003003)2.16682628
114Angiofibromas (HP:0010615)2.15466315
115Adenoma sebaceum (HP:0009720)2.15466315
116Lethargy (HP:0001254)2.15433548
117Aplasia/Hypoplasia of the uvula (HP:0010293)2.14654970
118Cheilitis (HP:0100825)2.13621129
119Short 5th finger (HP:0009237)2.12460178
120Skin nodule (HP:0200036)2.11167346
121Absent thumb (HP:0009777)2.10460418
122Abnormality of the preputium (HP:0100587)2.09487613
123Increased connective tissue (HP:0009025)2.07358810
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07279765
125Partial duplication of the phalanx of hand (HP:0009999)2.06981455
126Impulsivity (HP:0100710)2.06558512
127Postnatal microcephaly (HP:0005484)2.05929372
128Dicarboxylic aciduria (HP:0003215)2.04469520
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04469520
130Abnormality of reticulocytes (HP:0004312)2.04011005
131Fasciculations (HP:0002380)2.02912405
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02192016
133Abnormality of the pulmonary veins (HP:0011718)2.01642607
134Abnormality of the anterior horn cell (HP:0006802)2.01171090
135Degeneration of anterior horn cells (HP:0002398)2.01171090
136Pallor (HP:0000980)2.00881515
137Hypoplastic pelvis (HP:0008839)2.00072241
138Abnormality of DNA repair (HP:0003254)1.99308864
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98486210
140Respiratory failure (HP:0002878)1.98414976
141Aplasia/Hypoplasia of the macula (HP:0008059)1.98129755
142Tetraplegia (HP:0002445)1.98081736
143Poor suck (HP:0002033)1.97594541
144Triphalangeal thumb (HP:0001199)1.96815053
145Preauricular skin tag (HP:0000384)1.95425851
146Pendular nystagmus (HP:0012043)1.95266075
147Shawl scrotum (HP:0000049)1.94936363
148Aplastic anemia (HP:0001915)1.94313259
149Abnormal neuron morphology (HP:0012757)1.93596140
150Abnormality of the motor neurons (HP:0002450)1.93596140
151Poor head control (HP:0002421)1.93509992
152Pancreatic islet-cell hyperplasia (HP:0004510)1.93358065
153Poikiloderma (HP:0001029)1.90554043
154Leukodystrophy (HP:0002415)1.90363932
155Methylmalonic acidemia (HP:0002912)1.89262842
156Villous atrophy (HP:0011473)1.88460130
157Abnormality of small intestinal villus morphology (HP:0011472)1.88460130
158Secondary amenorrhea (HP:0000869)1.87553527
159Emotional lability (HP:0000712)1.86299141
160Megaloblastic anemia (HP:0001889)1.86220306
161Sparse eyelashes (HP:0000653)1.85505188
162Entropion (HP:0000621)1.85145775
163Hand muscle atrophy (HP:0009130)1.84936174
164Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84911287
165Pancytopenia (HP:0001876)1.84871059
166Limb hypertonia (HP:0002509)1.83152534
167Periauricular skin pits (HP:0100277)1.82961293
168Preauricular pit (HP:0004467)1.82961293
169Abnormal hemoglobin (HP:0011902)1.82634385
170Hyperammonemia (HP:0001987)1.80964013
171Opisthotonus (HP:0002179)1.76764811
172Optic disc pallor (HP:0000543)1.75878062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.03392920
2ERN15.33869855
3GRK54.53202671
4VRK24.26749778
5GRK64.15630564
6TTK2.98338510
7ADRBK22.97420166
8GRK12.73358767
9CSF1R2.57943250
10TSSK62.43911897
11PBK2.42999413
12STK102.28888439
13GRK72.27649837
14ZAK2.20477201
15MAPK72.14240645
16NME12.13322782
17TGFBR22.11786780
18BUB12.03614413
19BCKDK1.99256841
20EPHA21.97314237
21MATK1.96735930
22MOS1.89974741
23PLK31.86382784
24TYRO31.72509307
25TRIM281.69288628
26CDK71.65822891
27PLK41.54852050
28NUAK11.48319665
29PAK41.45691314
30NEK11.40578691
31PRKG21.40125350
32CDK191.37985955
33PLK11.37103034
34WEE11.31763049
35CHEK21.22119733
36WNK11.21571101
37TAF11.21191065
38MST41.21160291
39TESK21.20540093
40NME21.20056020
41AKT31.18564728
42SMG11.15630928
43CAMK41.14930404
44NTRK11.03726923
45MAP2K60.98634216
46ADRBK10.94296716
47MAP4K20.93216032
48DAPK10.89816723
49LATS20.87513230
50TAOK20.86813194
51MKNK10.84313724
52PIM20.83861289
53NEK20.82891442
54CSNK1G30.82283751
55LIMK10.81959012
56TLK10.80161183
57RPS6KB20.79776450
58HIPK20.77177807
59PRKCI0.76125246
60CDC70.74968452
61MAP3K100.72787380
62AURKA0.72690556
63MAP2K40.72535958
64AKT20.69860611
65MARK20.69579414
66MAPKAPK30.69380204
67RPS6KA40.68239018
68CSNK2A20.68173816
69CHEK10.67801772
70CSNK2A10.66851398
71FLT30.63684039
72AURKB0.62366746
73EIF2AK20.62010529
74ALK0.61853432
75WNK30.61669134
76CSNK1G10.61384873
77EIF2AK10.60743439
78CDK80.60074223
79LRRK20.59067773
80CSK0.58856938
81PRKD30.57520066
82KDR0.56051375
83EEF2K0.53667934
84WNK40.52984704
85MAP3K80.52625515
86SIK10.52044287
87MAPK120.51725750
88BRSK20.51677420
89BRAF0.51385642
90ARAF0.49873914
91STK160.48480438
92CDK10.47682447
93PAK10.46716319
94ILK0.45359120
95CSNK1A1L0.44941690
96PDK20.44054412
97CSNK1G20.43239943
98PRKCD0.42694325
99PDK40.42637787
100PDK30.42637787
101RPS6KA50.42466435
102MAPKAPK50.41855515
103SRPK10.41468653
104MAP3K70.41223870
105BCR0.40793004
106FGFR30.40784771
107CDK40.40128202
108CCNB10.39398063
109CDK20.39199783
110CLK10.38662290
111ACVR1B0.37819556
112DYRK30.37052630
113BMX0.35781749
114SIK30.33616699
115MTOR0.33519121
116SCYL20.33484054
117DAPK30.33031912
118LMTK20.31960907
119DYRK20.31905463
120BRSK10.31878214
121CDK140.31394363
122ABL20.30816118
123ITK0.30209453
124DYRK1B0.29739466
125CDK90.29439344
126IRAK30.29198999
127CDK11A0.28143666
128MAP3K50.28001123
129MAPK40.27769933
130PTK20.27176575
131IGF1R0.26783805
132BLK0.26778464
133PRKDC0.25788623
134PKN20.25384310
135STK38L0.24936040
136IKBKB0.24902281
137TESK10.24741638
138ATM0.24581942
139CSNK1E0.22899838
140EIF2AK30.22685968
141ATR0.22030621
142PRKACG0.20692874
143PINK10.20473861
144PASK0.20323006
145PIM10.18544603
146STK40.18257908
147TRIB30.17219535
148VRK10.17088238
149MAP2K30.16590800

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.90452089
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.61131287
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35705962
4Fructose and mannose metabolism_Homo sapiens_hsa000513.25163510
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39122906
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.33582951
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31425924
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29903717
9Galactose metabolism_Homo sapiens_hsa000522.29642576
10DNA replication_Homo sapiens_hsa030302.08333672
11One carbon pool by folate_Homo sapiens_hsa006701.96675263
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93932289
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93637359
14* Ribosome_Homo sapiens_hsa030101.85933421
15Arachidonic acid metabolism_Homo sapiens_hsa005901.81506100
16Carbon metabolism_Homo sapiens_hsa012001.81187852
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78002699
18Non-homologous end-joining_Homo sapiens_hsa034501.74675200
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73649295
20Protein export_Homo sapiens_hsa030601.68670814
21Folate biosynthesis_Homo sapiens_hsa007901.62037062
22RNA transport_Homo sapiens_hsa030131.61880558
23Mismatch repair_Homo sapiens_hsa034301.59640278
24Tryptophan metabolism_Homo sapiens_hsa003801.58637840
25Proteasome_Homo sapiens_hsa030501.54600438
26Biosynthesis of amino acids_Homo sapiens_hsa012301.54293343
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53829791
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53039057
29RNA polymerase_Homo sapiens_hsa030201.51541093
30Linoleic acid metabolism_Homo sapiens_hsa005911.50853170
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45258090
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40484242
33Chemical carcinogenesis_Homo sapiens_hsa052041.40417928
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36180812
35Homologous recombination_Homo sapiens_hsa034401.35613449
36Pentose phosphate pathway_Homo sapiens_hsa000301.35383645
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26414770
38Selenocompound metabolism_Homo sapiens_hsa004501.26058818
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.23356844
40Pyrimidine metabolism_Homo sapiens_hsa002401.22876151
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19994519
42Steroid biosynthesis_Homo sapiens_hsa001001.18857908
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.18492847
44Alzheimers disease_Homo sapiens_hsa050101.16931416
45Base excision repair_Homo sapiens_hsa034101.16498110
46Sulfur relay system_Homo sapiens_hsa041221.14266354
47Fatty acid degradation_Homo sapiens_hsa000711.06390431
48Fanconi anemia pathway_Homo sapiens_hsa034601.03949967
49Propanoate metabolism_Homo sapiens_hsa006401.02159752
50Spliceosome_Homo sapiens_hsa030401.00649564
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94108170
52Other glycan degradation_Homo sapiens_hsa005110.94012666
53RNA degradation_Homo sapiens_hsa030180.92684920
54Thyroid cancer_Homo sapiens_hsa052160.92369028
55Cell cycle_Homo sapiens_hsa041100.90380389
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90360790
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.90277915
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.89358657
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84653051
60Peroxisome_Homo sapiens_hsa041460.84150653
61Nucleotide excision repair_Homo sapiens_hsa034200.82818674
62N-Glycan biosynthesis_Homo sapiens_hsa005100.82497952
63Arginine biosynthesis_Homo sapiens_hsa002200.79077837
64Pyruvate metabolism_Homo sapiens_hsa006200.78766144
65Glutathione metabolism_Homo sapiens_hsa004800.77967375
66Parkinsons disease_Homo sapiens_hsa050120.75766170
67Oxidative phosphorylation_Homo sapiens_hsa001900.74664848
68Metabolic pathways_Homo sapiens_hsa011000.74368787
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72520630
70mRNA surveillance pathway_Homo sapiens_hsa030150.71125471
71Phenylalanine metabolism_Homo sapiens_hsa003600.69334086
72beta-Alanine metabolism_Homo sapiens_hsa004100.67918502
73Cardiac muscle contraction_Homo sapiens_hsa042600.66998139
74Butanoate metabolism_Homo sapiens_hsa006500.65831544
75PPAR signaling pathway_Homo sapiens_hsa033200.65500808
76p53 signaling pathway_Homo sapiens_hsa041150.65107413
77Vitamin digestion and absorption_Homo sapiens_hsa049770.64436257
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64145990
79Complement and coagulation cascades_Homo sapiens_hsa046100.63274861
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61896295
81Tyrosine metabolism_Homo sapiens_hsa003500.59964311
82Starch and sucrose metabolism_Homo sapiens_hsa005000.57114769
83Sulfur metabolism_Homo sapiens_hsa009200.57023443
84Retinol metabolism_Homo sapiens_hsa008300.55918802
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55230349
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54380298
87Fatty acid metabolism_Homo sapiens_hsa012120.54108007
88Huntingtons disease_Homo sapiens_hsa050160.53016225
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.51457065
90Regulation of autophagy_Homo sapiens_hsa041400.50239617
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49377405
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.47326601
93Oocyte meiosis_Homo sapiens_hsa041140.46444024
94Histidine metabolism_Homo sapiens_hsa003400.45280152
95Basal transcription factors_Homo sapiens_hsa030220.44866214
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44698997
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43818765
98Fat digestion and absorption_Homo sapiens_hsa049750.42968404
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41435260
100mTOR signaling pathway_Homo sapiens_hsa041500.40709598
101Arginine and proline metabolism_Homo sapiens_hsa003300.39864926
102Glycerolipid metabolism_Homo sapiens_hsa005610.38658255
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.38602372
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37003637
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36510405
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.35618152
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35384107
108Epstein-Barr virus infection_Homo sapiens_hsa051690.33588622
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.33204554
110Vibrio cholerae infection_Homo sapiens_hsa051100.32938023
111Purine metabolism_Homo sapiens_hsa002300.32456016
112Fatty acid elongation_Homo sapiens_hsa000620.31013142
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30666109
114Ovarian steroidogenesis_Homo sapiens_hsa049130.29460937
115Basal cell carcinoma_Homo sapiens_hsa052170.28785371
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27927770
117Lysine degradation_Homo sapiens_hsa003100.27148310
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24970358
119Bladder cancer_Homo sapiens_hsa052190.24179777
120Hedgehog signaling pathway_Homo sapiens_hsa043400.18359692
121Hippo signaling pathway_Homo sapiens_hsa043900.16887323
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11336598
123Collecting duct acid secretion_Homo sapiens_hsa049660.10628817
124Wnt signaling pathway_Homo sapiens_hsa043100.09422308
125Tight junction_Homo sapiens_hsa04530-0.0353210

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