MRPL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.32741043
2ATP synthesis coupled proton transport (GO:0015986)5.93235019
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.93235019
4viral transcription (GO:0019083)5.61813306
5ribosomal small subunit biogenesis (GO:0042274)5.56076418
6translational termination (GO:0006415)5.47366620
7ribosomal small subunit assembly (GO:0000028)5.29507061
8proteasome assembly (GO:0043248)5.28665940
9maturation of SSU-rRNA (GO:0030490)5.28526704
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.01025534
11ribosomal large subunit biogenesis (GO:0042273)4.87414858
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.82679922
13cotranslational protein targeting to membrane (GO:0006613)4.81700566
14translational elongation (GO:0006414)4.75066517
15protein targeting to ER (GO:0045047)4.73810003
16respiratory electron transport chain (GO:0022904)4.59615294
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.52181949
18termination of RNA polymerase III transcription (GO:0006386)4.52181949
19electron transport chain (GO:0022900)4.48489155
20protein localization to endoplasmic reticulum (GO:0070972)4.48430745
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.47998161
22cullin deneddylation (GO:0010388)4.44811292
23cellular protein complex disassembly (GO:0043624)4.43674660
24translational initiation (GO:0006413)4.37285785
25protein neddylation (GO:0045116)4.34337056
26DNA strand elongation (GO:0022616)4.32669660
27viral life cycle (GO:0019058)4.32299104
28regulation of mitochondrial translation (GO:0070129)4.28526426
29GTP biosynthetic process (GO:0006183)4.26751024
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18827883
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.18827883
32NADH dehydrogenase complex assembly (GO:0010257)4.18827883
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.18133326
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.17603392
35protein complex biogenesis (GO:0070271)4.16283801
36* translation (GO:0006412)4.16128955
37establishment of integrated proviral latency (GO:0075713)4.12923736
38protein deneddylation (GO:0000338)4.12880357
39spliceosomal snRNP assembly (GO:0000387)4.11830395
40CENP-A containing nucleosome assembly (GO:0034080)4.10843641
41establishment of protein localization to mitochondrial membrane (GO:0090151)4.09523298
42chromatin remodeling at centromere (GO:0031055)4.08573443
43DNA deamination (GO:0045006)4.00237242
44mitochondrial respiratory chain complex assembly (GO:0033108)3.97722726
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89145940
46ribonucleoprotein complex biogenesis (GO:0022613)3.88812908
47UTP biosynthetic process (GO:0006228)3.88108262
487-methylguanosine mRNA capping (GO:0006370)3.87387477
49chaperone-mediated protein transport (GO:0072321)3.86087228
507-methylguanosine RNA capping (GO:0009452)3.81889145
51RNA capping (GO:0036260)3.81889145
52protein complex disassembly (GO:0043241)3.81616797
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81348182
54negative regulation of ligase activity (GO:0051352)3.81348182
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77870484
56regulation of cellular amino acid metabolic process (GO:0006521)3.76553279
57DNA replication checkpoint (GO:0000076)3.74793026
58cellular component biogenesis (GO:0044085)3.71129190
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70105078
60macromolecular complex disassembly (GO:0032984)3.69470542
61guanosine-containing compound biosynthetic process (GO:1901070)3.69452560
62spliceosomal complex assembly (GO:0000245)3.68765854
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65783718
64purine nucleobase biosynthetic process (GO:0009113)3.62986682
65oxidative phosphorylation (GO:0006119)3.62307932
66DNA damage response, detection of DNA damage (GO:0042769)3.61143984
67rRNA modification (GO:0000154)3.61130314
68telomere maintenance via recombination (GO:0000722)3.61039758
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60626221
70formation of translation preinitiation complex (GO:0001731)3.58692842
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.58448038
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.58448038
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55326453
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55326453
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55326453
76DNA unwinding involved in DNA replication (GO:0006268)3.53124974
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51316329
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.51069002
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.50817723
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50817723
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.49986083
82nucleobase biosynthetic process (GO:0046112)3.49417537
83establishment of protein localization to mitochondrion (GO:0072655)3.47476885
84rRNA processing (GO:0006364)3.45253421
85protein targeting to mitochondrion (GO:0006626)3.45206532
86establishment of viral latency (GO:0019043)3.43307066
87mitotic recombination (GO:0006312)3.43041897
88ribosome assembly (GO:0042255)3.41966522
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40902284
90transcription-coupled nucleotide-excision repair (GO:0006283)3.39397596
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39186587
92DNA replication-independent nucleosome organization (GO:0034724)3.33553751
93DNA replication-independent nucleosome assembly (GO:0006336)3.33553751
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32751773
95UTP metabolic process (GO:0046051)3.32655904
96nucleobase-containing small molecule interconversion (GO:0015949)3.31425820
97mitotic metaphase plate congression (GO:0007080)3.30781127
98rRNA metabolic process (GO:0016072)3.30161288
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28761956
100ribosome biogenesis (GO:0042254)3.27052035
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.26082009
102pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26017922
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24334298
104respiratory chain complex IV assembly (GO:0008535)3.23517861
105purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23489327
106positive regulation of ligase activity (GO:0051351)3.23328501
107viral mRNA export from host cell nucleus (GO:0046784)3.21788363
108IMP biosynthetic process (GO:0006188)3.21046844
109histone exchange (GO:0043486)3.20932382
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.20274315
111CTP biosynthetic process (GO:0006241)3.19766800
112CTP metabolic process (GO:0046036)3.19766800
113pseudouridine synthesis (GO:0001522)3.19432349
114protein localization to mitochondrion (GO:0070585)3.18465367
115termination of RNA polymerase I transcription (GO:0006363)3.17995487
116transcription from RNA polymerase I promoter (GO:0006360)3.16068137
117nuclear-transcribed mRNA catabolic process (GO:0000956)3.15507469
118DNA strand elongation involved in DNA replication (GO:0006271)3.14408378
119telomere maintenance via semi-conservative replication (GO:0032201)3.10957137
120regulation of ubiquitin-protein transferase activity (GO:0051438)3.10216568
121nucleotide-excision repair, DNA gap filling (GO:0006297)3.06419373
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.06243931
123protein localization to kinetochore (GO:0034501)3.04825756
124telomere maintenance via telomere lengthening (GO:0010833)3.04444357
125protein targeting to membrane (GO:0006612)3.04096055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92418101
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.41523554
3* EST1_17652178_ChIP-ChIP_JURKAT_Human4.29300452
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.29039445
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02625618
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88781383
7E2F7_22180533_ChIP-Seq_HELA_Human3.76256002
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.75530903
9* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.66714250
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.55498287
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48709646
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39915038
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39660748
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23250499
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13502466
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11156083
17MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08241382
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89942902
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74857203
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64252658
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.58616676
22XRN2_22483619_ChIP-Seq_HELA_Human2.57350948
23VDR_23849224_ChIP-Seq_CD4+_Human2.43974961
24DCP1A_22483619_ChIP-Seq_HELA_Human2.40469042
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39541450
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34350811
27* YY1_21170310_ChIP-Seq_MESCs_Mouse2.31841019
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.31373051
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.25405980
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20880357
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.15131716
32TTF2_22483619_ChIP-Seq_HELA_Human2.14407122
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13702556
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11150789
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06725399
36ELK1_19687146_ChIP-ChIP_HELA_Human2.02725831
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91408515
38GABP_19822575_ChIP-Seq_HepG2_Human1.91128901
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85887501
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76482316
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73447559
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67779823
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66520741
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63697104
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60674452
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54168404
47MYC_18940864_ChIP-ChIP_HL60_Human1.49601468
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48702897
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43256862
50* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42451091
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41485541
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39277671
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37442714
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.37308567
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35279665
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35079679
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33630998
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27808903
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27470647
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25002558
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22567485
62ZNF263_19887448_ChIP-Seq_K562_Human1.21304334
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20755980
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19743152
65* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18891607
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15978405
67IRF1_19129219_ChIP-ChIP_H3396_Human1.15742539
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15080484
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14660267
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12222593
71* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11783088
72CIITA_25753668_ChIP-Seq_RAJI_Human1.06396208
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.06234054
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03170163
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.01138545
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98888281
77POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98151566
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97849452
79* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95978886
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93477919
81SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93389240
82KDM5A_27292631_Chip-Seq_BREAST_Human0.92698116
83* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92138756
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91485305
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90665948
86E2F1_21310950_ChIP-Seq_MCF-7_Human0.90571608
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90469205
88* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89210504
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88219137
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87823816
91TFEB_21752829_ChIP-Seq_HELA_Human0.87489611
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86386747
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85177058
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84876955
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84073727
96* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84036380
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83661074
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83398895
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83026930
100VDR_22108803_ChIP-Seq_LS180_Human0.81568555
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81123744
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80666300
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77185819
104AR_21909140_ChIP-Seq_LNCAP_Human0.76781352
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76525948
106FUS_26573619_Chip-Seq_HEK293_Human0.75685269
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.75558308
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73726826
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73073481
110* YY1_22570637_ChIP-Seq_MALME-3M_Human0.72197957
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72135731
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.69465953
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67769235
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67172273
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67135973
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63844538
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.63775031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.71385774
2MP0006292_abnormal_olfactory_placode3.23434629
3MP0001529_abnormal_vocalization2.94464168
4MP0004957_abnormal_blastocyst_morpholog2.85852431
5MP0003693_abnormal_embryo_hatching2.78430095
6MP0003880_abnormal_central_pattern2.54633105
7MP0008058_abnormal_DNA_repair2.53559748
8MP0003136_yellow_coat_color2.53301933
9MP0010094_abnormal_chromosome_stability2.51681542
10MP0008932_abnormal_embryonic_tissue2.51338473
11MP0001188_hyperpigmentation2.42469000
12MP0003806_abnormal_nucleotide_metabolis2.42444880
13MP0003111_abnormal_nucleus_morphology2.38761716
14MP0001905_abnormal_dopamine_level2.26906314
15MP0004133_heterotaxia2.19243796
16MP0003077_abnormal_cell_cycle2.15405816
17MP0003718_maternal_effect2.15227201
18MP0006035_abnormal_mitochondrial_morpho2.07787457
19MP0006036_abnormal_mitochondrial_physio2.05408362
20MP0008057_abnormal_DNA_replication2.03393781
21MP0006276_abnormal_autonomic_nervous2.01295248
22MP0003786_premature_aging1.88382601
23MP0003123_paternal_imprinting1.79463011
24MP0004142_abnormal_muscle_tone1.71652253
25MP0003315_abnormal_perineum_morphology1.67201410
26MP0002638_abnormal_pupillary_reflex1.62831050
27MP0002102_abnormal_ear_morphology1.60568930
28MP0002160_abnormal_reproductive_system1.57436011
29MP0009697_abnormal_copulation1.55887026
30MP0008007_abnormal_cellular_replicative1.55014334
31MP0002163_abnormal_gland_morphology1.54902171
32MP0000049_abnormal_middle_ear1.49678341
33MP0003186_abnormal_redox_activity1.48192810
34MP0002080_prenatal_lethality1.46569189
35MP0005423_abnormal_somatic_nervous1.45126033
36MP0010030_abnormal_orbit_morphology1.42320233
37MP0001672_abnormal_embryogenesis/_devel1.40986938
38MP0005380_embryogenesis_phenotype1.40986938
39MP0008789_abnormal_olfactory_epithelium1.40318884
40MP0002736_abnormal_nociception_after1.39886557
41MP0009672_abnormal_birth_weight1.35757067
42MP0002751_abnormal_autonomic_nervous1.31792355
43MP0001986_abnormal_taste_sensitivity1.31163664
44MP0000490_abnormal_crypts_of1.30149093
45MP0005501_abnormal_skin_physiology1.26710679
46MP0002085_abnormal_embryonic_tissue1.26587361
47MP0000566_synostosis1.26555314
48MP0003938_abnormal_ear_development1.22146755
49MP0001968_abnormal_touch/_nociception1.21831472
50MP0003011_delayed_dark_adaptation1.20690840
51MP0002019_abnormal_tumor_incidence1.19839520
52MP0003984_embryonic_growth_retardation1.19156558
53MP0006072_abnormal_retinal_apoptosis1.18542281
54MP0002938_white_spotting1.17848443
55MP0004185_abnormal_adipocyte_glucose1.17421122
56MP0008877_abnormal_DNA_methylation1.14436417
57MP0002088_abnormal_embryonic_growth/wei1.13116131
58MP0004147_increased_porphyrin_level1.12679243
59MP0003890_abnormal_embryonic-extraembry1.10887587
60MP0002396_abnormal_hematopoietic_system1.10256793
61MP0001346_abnormal_lacrimal_gland1.06522564
62MP0003121_genomic_imprinting1.06040782
63MP0001764_abnormal_homeostasis1.05246308
64MP0005389_reproductive_system_phenotype1.03144842
65MP0005394_taste/olfaction_phenotype1.02930871
66MP0005499_abnormal_olfactory_system1.02930871
67MP0002796_impaired_skin_barrier1.02776643
68MP0000372_irregular_coat_pigmentation1.01646314
69MP0009333_abnormal_splenocyte_physiolog1.01301968
70MP0005409_darkened_coat_color1.01282917
71MP0001881_abnormal_mammary_gland1.00751145
72MP0003646_muscle_fatigue1.00255461
73MP0002084_abnormal_developmental_patter0.99482583
74MP0003122_maternal_imprinting0.97835789
75MP0000778_abnormal_nervous_system0.97055800
76MP0001730_embryonic_growth_arrest0.97017240
77MP0002111_abnormal_tail_morphology0.96311553
78MP0002697_abnormal_eye_size0.95995494
79MP0003119_abnormal_digestive_system0.95200440
80MP0000631_abnormal_neuroendocrine_gland0.94992989
81MP0004145_abnormal_muscle_electrophysio0.94754182
82MP0001727_abnormal_embryo_implantation0.94659879
83MP0002210_abnormal_sex_determination0.94381993
84MP0005075_abnormal_melanosome_morpholog0.93339237
85MP0000015_abnormal_ear_pigmentation0.93273448
86MP0001984_abnormal_olfaction0.92986975
87MP0008995_early_reproductive_senescence0.92872942
88MP0005451_abnormal_body_composition0.91434141
89MP0002277_abnormal_respiratory_mucosa0.91175366
90MP0005408_hypopigmentation0.91046000
91MP0002132_abnormal_respiratory_system0.90624544
92MP0001853_heart_inflammation0.89915343
93MP0002653_abnormal_ependyma_morphology0.88300270
94MP0000537_abnormal_urethra_morphology0.87995791
95MP0001485_abnormal_pinna_reflex0.87269196
96MP0004233_abnormal_muscle_weight0.85124130
97MP0002249_abnormal_larynx_morphology0.84630348
98MP0001661_extended_life_span0.83121316
99MP0002272_abnormal_nervous_system0.82274699
100MP0000358_abnormal_cell_content/0.82040499
101MP0010307_abnormal_tumor_latency0.81975609
102MP0005084_abnormal_gallbladder_morpholo0.81699226
103MP0000026_abnormal_inner_ear0.80192451
104MP0001286_abnormal_eye_development0.79299150
105MP0002127_abnormal_cardiovascular_syste0.78695552
106MP0001145_abnormal_male_reproductive0.78274670
107MP0002752_abnormal_somatic_nervous0.78075432
108MP0005266_abnormal_metabolism0.77949826
109MP0002086_abnormal_extraembryonic_tissu0.77798123
110MP0003937_abnormal_limbs/digits/tail_de0.77513764
111MP0001697_abnormal_embryo_size0.76773693
112MP0005253_abnormal_eye_physiology0.76483268
113MP0001929_abnormal_gametogenesis0.76458307
114MP0002735_abnormal_chemical_nociception0.75282598
115MP0008260_abnormal_autophagy0.75072740
116MP0005379_endocrine/exocrine_gland_phen0.74724468
117MP0004197_abnormal_fetal_growth/weight/0.74121439
118MP0000653_abnormal_sex_gland0.74022630
119MP0001919_abnormal_reproductive_system0.73674597
120MP0005410_abnormal_fertilization0.73564617
121MP0001293_anophthalmia0.73043576
122MP0002877_abnormal_melanocyte_morpholog0.72111138
123MP0005174_abnormal_tail_pigmentation0.71290944
124MP0002572_abnormal_emotion/affect_behav0.70882634
125MP0003698_abnormal_male_reproductive0.70861871
126MP0005332_abnormal_amino_acid0.70622446
127MP0000350_abnormal_cell_proliferation0.70574800
128MP0002734_abnormal_mechanical_nocicepti0.70164860
129MP0002184_abnormal_innervation0.69739475
130MP0003567_abnormal_fetal_cardiomyocyte0.69712325
131MP0002837_dystrophic_cardiac_calcinosis0.69220832
132MP0000313_abnormal_cell_death0.69153777
133MP0003941_abnormal_skin_development0.68585931
134MP0009745_abnormal_behavioral_response0.68539500
135MP0005330_cardiomyopathy0.63560108
136MP0005384_cellular_phenotype0.63111860
137MP0001119_abnormal_female_reproductive0.61523353
138MP0009053_abnormal_anal_canal0.61174257
139MP0000678_abnormal_parathyroid_gland0.58230140
140MP0002234_abnormal_pharynx_morphology0.55087828
141MP0000627_abnormal_mammary_gland0.55060839
142MP0000750_abnormal_muscle_regeneration0.54738151
143MP0002233_abnormal_nose_morphology0.53177859
144MP0000762_abnormal_tongue_morphology0.51689809
145MP0002092_abnormal_eye_morphology0.50123324
146MP0008873_increased_physiological_sensi0.50023926
147MP0005319_abnormal_enzyme/_coenzyme0.49590145
148MP0002161_abnormal_fertility/fecundity0.48996820

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.88388795
2Mitochondrial inheritance (HP:0001427)5.57784498
3Abnormal mitochondria in muscle tissue (HP:0008316)5.30297535
4Hepatocellular necrosis (HP:0001404)5.18409435
5Increased CSF lactate (HP:0002490)4.97028899
6Increased hepatocellular lipid droplets (HP:0006565)4.92368031
7Progressive macrocephaly (HP:0004481)4.85276693
8Acute encephalopathy (HP:0006846)4.79319470
9Reticulocytopenia (HP:0001896)4.45786907
10Lipid accumulation in hepatocytes (HP:0006561)4.40449254
11Hepatic necrosis (HP:0002605)4.40424636
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.24878926
13Abnormality of glycolysis (HP:0004366)4.24080320
14Increased serum pyruvate (HP:0003542)4.24080320
15Renal Fanconi syndrome (HP:0001994)4.02313344
16Abnormality of cells of the erythroid lineage (HP:0012130)3.92969543
173-Methylglutaconic aciduria (HP:0003535)3.85166668
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.84226343
19Increased serum lactate (HP:0002151)3.77081429
20Abnormal number of erythroid precursors (HP:0012131)3.68640663
21Macrocytic anemia (HP:0001972)3.54956511
22Exercise intolerance (HP:0003546)3.46684886
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45775199
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45775199
25Increased intramyocellular lipid droplets (HP:0012240)3.44619818
26Cerebral edema (HP:0002181)3.34465298
27Respiratory failure (HP:0002878)3.33822514
28Exertional dyspnea (HP:0002875)3.28962709
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21046859
30Lactic acidosis (HP:0003128)3.20322650
31Multiple enchondromatosis (HP:0005701)3.08139007
32Optic disc pallor (HP:0000543)3.04471422
33Progressive muscle weakness (HP:0003323)3.01509693
34Chromsome breakage (HP:0040012)2.96049459
35Leukodystrophy (HP:0002415)2.94513444
36Microvesicular hepatic steatosis (HP:0001414)2.91513223
37Cerebral hypomyelination (HP:0006808)2.90510959
38Birth length less than 3rd percentile (HP:0003561)2.88562533
39Increased muscle lipid content (HP:0009058)2.86848886
40Pallor (HP:0000980)2.82245955
41Respiratory difficulties (HP:0002880)2.74057811
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70629209
43Progressive external ophthalmoplegia (HP:0000590)2.65589966
44Breast hypoplasia (HP:0003187)2.64288760
45Colon cancer (HP:0003003)2.56640071
46Emotional lability (HP:0000712)2.53533962
47CNS demyelination (HP:0007305)2.50485164
48Oral leukoplakia (HP:0002745)2.49631192
49Reduced antithrombin III activity (HP:0001976)2.47547729
50Abnormality of methionine metabolism (HP:0010901)2.44780711
51Degeneration of anterior horn cells (HP:0002398)2.33121870
52Abnormality of the anterior horn cell (HP:0006802)2.33121870
53Absent thumb (HP:0009777)2.32865583
54Abnormality of renal resorption (HP:0011038)2.32717650
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.27625002
56Rough bone trabeculation (HP:0100670)2.26987278
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26623009
58Abnormal protein N-linked glycosylation (HP:0012347)2.26623009
59Abnormal protein glycosylation (HP:0012346)2.26623009
60Abnormal glycosylation (HP:0012345)2.26623009
61Hyperglycinemia (HP:0002154)2.26046509
62Abnormality of serum amino acid levels (HP:0003112)2.23454828
63Abnormality of placental membranes (HP:0011409)2.18860109
64Amniotic constriction ring (HP:0009775)2.18860109
65Type I transferrin isoform profile (HP:0003642)2.17440618
66Testicular atrophy (HP:0000029)2.14727577
67Trismus (HP:0000211)2.13248648
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13138595
69Megaloblastic anemia (HP:0001889)2.10094309
70Sparse eyelashes (HP:0000653)2.07593258
71Hyperphosphaturia (HP:0003109)2.06963825
72Abnormality of chromosome stability (HP:0003220)2.06538794
73Carpal bone hypoplasia (HP:0001498)2.06384478
74Aplastic anemia (HP:0001915)2.05496778
75Aplasia/hypoplasia of the uterus (HP:0008684)2.04100690
76Selective tooth agenesis (HP:0001592)2.04049845
77Horseshoe kidney (HP:0000085)1.99456481
78Methylmalonic aciduria (HP:0012120)1.98641411
79Duodenal stenosis (HP:0100867)1.95145080
80Small intestinal stenosis (HP:0012848)1.95145080
81Ragged-red muscle fibers (HP:0003200)1.94925815
82Abnormal lung lobation (HP:0002101)1.93727845
83Facial cleft (HP:0002006)1.93230815
84Duplicated collecting system (HP:0000081)1.91873525
85Hyperglycinuria (HP:0003108)1.91644512
86Myelodysplasia (HP:0002863)1.90172907
87Patellar aplasia (HP:0006443)1.89645285
88Medial flaring of the eyebrow (HP:0010747)1.89366078
89Pancreatic cysts (HP:0001737)1.89034342
90Gout (HP:0001997)1.87923479
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86969212
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86602763
93Dicarboxylic aciduria (HP:0003215)1.86602763
94Triphalangeal thumb (HP:0001199)1.86332703
95Delusions (HP:0000746)1.86168173
96Aplasia/Hypoplasia of the patella (HP:0006498)1.85733494
97Lethargy (HP:0001254)1.85352446
98Abnormality of the labia minora (HP:0012880)1.82186541
99Abnormality of reticulocytes (HP:0004312)1.81598770
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79339161
101Cellular immunodeficiency (HP:0005374)1.77905880
102Secondary amenorrhea (HP:0000869)1.76213552
103Absent radius (HP:0003974)1.75956423
104Aplasia/Hypoplasia involving the musculature (HP:0001460)1.74615990
105Parakeratosis (HP:0001036)1.74473038
106Abnormality of serine family amino acid metabolism (HP:0010894)1.73220667
107Abnormality of glycine metabolism (HP:0010895)1.73220667
108Glycosuria (HP:0003076)1.73033762
109Abnormality of urine glucose concentration (HP:0011016)1.73033762
110Methylmalonic acidemia (HP:0002912)1.73028735
111Pancytopenia (HP:0001876)1.72832806
112Gliosis (HP:0002171)1.70131677
113Microretrognathia (HP:0000308)1.69734657
114True hermaphroditism (HP:0010459)1.69702053
115Abnormal hemoglobin (HP:0011902)1.69154395
116Aplasia involving forearm bones (HP:0009822)1.68102030
117Absent forearm bone (HP:0003953)1.68102030
118Abnormality of the renal collecting system (HP:0004742)1.66440535
119Abnormal trabecular bone morphology (HP:0100671)1.64214304
120Abnormal respiratory epithelium morphology (HP:0012253)1.64085862
121Abnormal respiratory motile cilium morphology (HP:0005938)1.64085862
122X-linked dominant inheritance (HP:0001423)1.62830075
123Blindness (HP:0000618)1.62661493
124Supernumerary spleens (HP:0009799)1.62318723
125Irregular epiphyses (HP:0010582)1.60670946
126Stenosis of the external auditory canal (HP:0000402)1.60316914
127Abnormality of the preputium (HP:0100587)1.60312247
128Abnormal urine phosphate concentration (HP:0012599)1.59706098
129Meckel diverticulum (HP:0002245)1.58008767
130Unsteady gait (HP:0002317)1.55964333
131Gait imbalance (HP:0002141)1.55552528
132Congenital primary aphakia (HP:0007707)1.55419991
133Fibular aplasia (HP:0002990)1.55094537
134Abnormal hair whorl (HP:0010721)1.54815821
135Abnormality of alanine metabolism (HP:0010916)1.54814353
136Hyperalaninemia (HP:0003348)1.54814353
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.54814353
138Postnatal microcephaly (HP:0005484)1.54497074
139Abnormality of the ileum (HP:0001549)1.54338580
140Pancreatic fibrosis (HP:0100732)1.54279566
141Cleft eyelid (HP:0000625)1.54230666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.05247604
2BUB14.11379873
3TLK13.86231520
4STK163.56716921
5SRPK13.18086054
6NME23.02634877
7WEE13.02509850
8EIF2AK12.89956549
9NME12.69498810
10VRK12.50739826
11CASK2.28420440
12PBK2.01024799
13BRAF1.92229116
14ARAF1.85061507
15TSSK61.82473160
16PNCK1.78844504
17TESK21.77670518
18MKNK11.64647531
19SMG11.59670475
20TAF11.58068091
21EIF2AK31.45686384
22MKNK21.41591028
23CDC71.41385168
24BCR1.39539650
25DYRK21.38440327
26CDK191.35876187
27SCYL21.34312309
28DYRK31.30898045
29AURKA1.30529465
30BCKDK1.27585647
31PLK31.26373165
32LIMK11.22407233
33BMPR1B1.20233986
34CCNB11.20122203
35PAK41.19579588
36PLK11.18413756
37PIM21.14506584
38BRSK21.11908004
39MAP3K121.11394409
40PLK41.10508804
41PDK21.02872936
42MST41.01517060
43STK40.96435266
44TTK0.94352496
45ZAK0.94184846
46CDK80.93045265
47NEK20.90376439
48MAP2K70.89574269
49ADRBK20.89374185
50PRPF4B0.88132752
51EPHA20.86922715
52NUAK10.85722484
53IRAK30.84799703
54AKT30.84605179
55MYLK0.83098218
56TESK10.81607936
57CHEK10.81574904
58AURKB0.80287565
59RPS6KA40.79925976
60MARK10.78994604
61MAPK130.78816999
62CSNK2A20.76947857
63BRSK10.75790881
64ACVR1B0.75747939
65CSNK2A10.75660118
66STK390.75434489
67EPHA40.75368530
68MAP3K80.75303229
69YES10.75114237
70CDK40.72127308
71DAPK30.72091918
72OBSCN0.71425648
73STK38L0.70547061
74CDK70.70289023
75TRIM280.69889323
76ATR0.69777995
77PRKCI0.68790629
78MAP3K100.67151162
79OXSR10.67146992
80PASK0.64859214
81GRK70.60150448
82TNIK0.60012279
83RPS6KB20.59913998
84ILK0.59554707
85LRRK20.59543698
86UHMK10.59059477
87CHEK20.58254361
88PLK20.57654321
89PAK10.57225866
90MUSK0.56327825
91EIF2AK20.55468458
92CAMK2B0.54429796
93ATM0.53579498
94ABL20.53197074
95IRAK40.48853829
96CSNK1G10.48709120
97NEK10.48320936
98BMPR20.48311850
99CSNK1G30.47559792
100PDK30.47215559
101PDK40.47215559
102MST1R0.46795982
103ALK0.46751606
104DAPK10.44524122
105STK100.44517582
106TAOK20.44122327
107LATS20.43708337
108CDK140.43384282
109CDK20.43274588
110ERBB40.42806870
111MAP3K110.42112520
112ADRBK10.41617494
113KDR0.41608939
114CDK10.41410199
115CDK180.40882617
116WNK30.40588193
117CLK10.40373701
118PKN10.39923691
119PRKCG0.39486909
120TGFBR10.38439460
121CDK11A0.38144522
122RPS6KA50.37700011
123GRK50.37646484
124AKT20.37436785
125CDK90.37342927
126CDK150.35667096
127MAP4K20.34962301
128FLT30.34473185
129PIM10.33241839
130CSNK1A1L0.33179766
131CSNK1E0.29657313
132CSNK1G20.27019385
133PRKDC0.18414043

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.24027672
2Proteasome_Homo sapiens_hsa030504.52828381
3Oxidative phosphorylation_Homo sapiens_hsa001904.42705071
4RNA polymerase_Homo sapiens_hsa030203.91675971
5Parkinsons disease_Homo sapiens_hsa050123.88751352
6Huntingtons disease_Homo sapiens_hsa050162.99870751
7DNA replication_Homo sapiens_hsa030302.90284920
8Mismatch repair_Homo sapiens_hsa034302.74719023
9Spliceosome_Homo sapiens_hsa030402.68517230
10Alzheimers disease_Homo sapiens_hsa050102.68156180
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55697872
12Pyrimidine metabolism_Homo sapiens_hsa002402.43418934
13Homologous recombination_Homo sapiens_hsa034402.38645304
14Protein export_Homo sapiens_hsa030602.33582784
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16292913
16Nucleotide excision repair_Homo sapiens_hsa034202.15954652
17RNA transport_Homo sapiens_hsa030131.90800067
18Base excision repair_Homo sapiens_hsa034101.84396882
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68163040
20Basal transcription factors_Homo sapiens_hsa030221.65334122
21Fanconi anemia pathway_Homo sapiens_hsa034601.63273644
22Cardiac muscle contraction_Homo sapiens_hsa042601.61387612
23Purine metabolism_Homo sapiens_hsa002301.44955713
24One carbon pool by folate_Homo sapiens_hsa006701.42381020
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41154870
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41063211
27RNA degradation_Homo sapiens_hsa030181.36168941
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34281083
29Non-homologous end-joining_Homo sapiens_hsa034501.17295012
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11210401
31Cell cycle_Homo sapiens_hsa041101.04376021
32Sulfur relay system_Homo sapiens_hsa041220.99678867
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99185933
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98355312
35Fatty acid elongation_Homo sapiens_hsa000620.96915223
36Glutathione metabolism_Homo sapiens_hsa004800.89950270
37mRNA surveillance pathway_Homo sapiens_hsa030150.88861091
38Collecting duct acid secretion_Homo sapiens_hsa049660.83855232
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83098195
40Folate biosynthesis_Homo sapiens_hsa007900.79643964
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.78927446
42Selenocompound metabolism_Homo sapiens_hsa004500.77266147
43Metabolic pathways_Homo sapiens_hsa011000.77064885
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76326014
45Epstein-Barr virus infection_Homo sapiens_hsa051690.69338227
46Pyruvate metabolism_Homo sapiens_hsa006200.67703516
47Arachidonic acid metabolism_Homo sapiens_hsa005900.67291195
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67135554
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67045062
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.66575033
51Vitamin B6 metabolism_Homo sapiens_hsa007500.66402446
52Carbon metabolism_Homo sapiens_hsa012000.65112672
53Systemic lupus erythematosus_Homo sapiens_hsa053220.64227171
54Galactose metabolism_Homo sapiens_hsa000520.60517771
55N-Glycan biosynthesis_Homo sapiens_hsa005100.60124599
56Vibrio cholerae infection_Homo sapiens_hsa051100.59385493
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57193109
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56432796
59Biosynthesis of amino acids_Homo sapiens_hsa012300.55484308
60Phototransduction_Homo sapiens_hsa047440.49846859
61Nicotine addiction_Homo sapiens_hsa050330.46788282
62Oocyte meiosis_Homo sapiens_hsa041140.46456811
63Pentose phosphate pathway_Homo sapiens_hsa000300.46106309
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45880604
65Arginine and proline metabolism_Homo sapiens_hsa003300.44365164
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44166371
67Propanoate metabolism_Homo sapiens_hsa006400.43893345
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42536479
69Steroid biosynthesis_Homo sapiens_hsa001000.42293600
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.41052849
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41032687
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40628250
73Vitamin digestion and absorption_Homo sapiens_hsa049770.40434529
74Fructose and mannose metabolism_Homo sapiens_hsa000510.35838472
75Alcoholism_Homo sapiens_hsa050340.33829549
76Tyrosine metabolism_Homo sapiens_hsa003500.32652666
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32587374
78Fatty acid metabolism_Homo sapiens_hsa012120.32467763
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32243242
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32043429
81Phenylalanine metabolism_Homo sapiens_hsa003600.29244937
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28397260
83p53 signaling pathway_Homo sapiens_hsa041150.28337976
84Regulation of autophagy_Homo sapiens_hsa041400.27884499
85Linoleic acid metabolism_Homo sapiens_hsa005910.27486408
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25977325
87Fatty acid degradation_Homo sapiens_hsa000710.25741064
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25355319
89Ether lipid metabolism_Homo sapiens_hsa005650.22359643
90Arginine biosynthesis_Homo sapiens_hsa002200.21442178
91Viral carcinogenesis_Homo sapiens_hsa052030.20852059
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18877302
93Butanoate metabolism_Homo sapiens_hsa006500.18718178
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18254017
95Thyroid cancer_Homo sapiens_hsa052160.17446617
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17116759
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16554391
98beta-Alanine metabolism_Homo sapiens_hsa004100.16547156
99Synaptic vesicle cycle_Homo sapiens_hsa047210.16394703
100Peroxisome_Homo sapiens_hsa041460.14510122
101Allograft rejection_Homo sapiens_hsa053300.14140793
102Basal cell carcinoma_Homo sapiens_hsa052170.13735350
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13334340
104Autoimmune thyroid disease_Homo sapiens_hsa053200.13318634
105HTLV-I infection_Homo sapiens_hsa051660.11593804
106Serotonergic synapse_Homo sapiens_hsa047260.11241873
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10899098
108Rheumatoid arthritis_Homo sapiens_hsa053230.10685221
109Primary immunodeficiency_Homo sapiens_hsa053400.09788957
110Fat digestion and absorption_Homo sapiens_hsa049750.07586806
111Tryptophan metabolism_Homo sapiens_hsa003800.05755231
112Herpes simplex infection_Homo sapiens_hsa051680.05727573
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05493312
114Chemical carcinogenesis_Homo sapiens_hsa052040.05399005
115Shigellosis_Homo sapiens_hsa051310.04205871
116Sulfur metabolism_Homo sapiens_hsa009200.03869710
117Graft-versus-host disease_Homo sapiens_hsa053320.03708584
118Taste transduction_Homo sapiens_hsa047420.03624317
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03418449
120Sphingolipid metabolism_Homo sapiens_hsa006000.03371857
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.02704030
122Hedgehog signaling pathway_Homo sapiens_hsa043400.02231111
123Bladder cancer_Homo sapiens_hsa052190.02208955
124Type I diabetes mellitus_Homo sapiens_hsa049400.02068203

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