MRPL12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)7.89907293
2DNA deamination (GO:0045006)7.47276958
3replication fork processing (GO:0031297)6.55183460
4embryonic process involved in female pregnancy (GO:0060136)6.07962678
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.61505471
6positive regulation of protein homooligomerization (GO:0032464)5.51171536
7ribosomal small subunit biogenesis (GO:0042274)5.41055955
8oxidative demethylation (GO:0070989)5.27876757
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.22571240
10mitochondrial DNA metabolic process (GO:0032042)5.21402981
11establishment of apical/basal cell polarity (GO:0035089)5.07810795
12viral mRNA export from host cell nucleus (GO:0046784)5.03681822
13formation of translation preinitiation complex (GO:0001731)4.97225815
14somatic hypermutation of immunoglobulin genes (GO:0016446)4.92173968
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.92173968
16regulation of integrin activation (GO:0033623)4.88467346
17regulation of protein homooligomerization (GO:0032462)4.80366502
18telomere maintenance via semi-conservative replication (GO:0032201)4.66850487
19mitotic G1 DNA damage checkpoint (GO:0031571)4.64562421
20DNA unwinding involved in DNA replication (GO:0006268)4.39536033
21DNA strand renaturation (GO:0000733)4.38691833
22protein maturation by protein folding (GO:0022417)4.37830689
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.34807778
24establishment of monopolar cell polarity (GO:0061162)4.34807778
25glutamine family amino acid biosynthetic process (GO:0009084)4.34647490
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33228603
27regulation of mitochondrial translation (GO:0070129)4.27308779
28negative regulation of fatty acid biosynthetic process (GO:0045717)4.24653450
29* transcription from mitochondrial promoter (GO:0006390)4.17516635
30poly(A)+ mRNA export from nucleus (GO:0016973)4.12995830
31ribosomal small subunit assembly (GO:0000028)4.12371256
32regulation of translational fidelity (GO:0006450)4.12364666
33mitotic G1/S transition checkpoint (GO:0044819)4.08835654
34base-excision repair (GO:0006284)4.06886838
35maturation of SSU-rRNA (GO:0030490)4.06640586
36nucleotide-excision repair, DNA gap filling (GO:0006297)4.06480161
37negative regulation of cell cycle arrest (GO:0071157)4.05043770
38viral transcription (GO:0019083)4.04509934
39G1 DNA damage checkpoint (GO:0044783)4.04363605
40peptidyl-arginine omega-N-methylation (GO:0035247)4.02001060
41ribonucleoprotein complex biogenesis (GO:0022613)4.00972700
42establishment of integrated proviral latency (GO:0075713)3.98576796
43DNA strand elongation involved in DNA replication (GO:0006271)3.98437589
44nucleobase-containing small molecule interconversion (GO:0015949)3.96984679
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.90656536
46negative regulation of JAK-STAT cascade (GO:0046426)3.87849915
47translational termination (GO:0006415)3.81514830
48mRNA cleavage (GO:0006379)3.80110595
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78584572
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.74321408
51telomere maintenance via recombination (GO:0000722)3.72829494
52DNA strand elongation (GO:0022616)3.72445425
53DNA integration (GO:0015074)3.69659297
54translational elongation (GO:0006414)3.65936887
55ribosomal large subunit biogenesis (GO:0042273)3.65701571
56GDP-mannose metabolic process (GO:0019673)3.64142169
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.62299052
58oxidative phosphorylation (GO:0006119)3.59206148
59embryonic placenta development (GO:0001892)3.58158998
60cellular response to zinc ion (GO:0071294)3.57530306
61mitotic chromosome condensation (GO:0007076)3.56326186
62double-strand break repair via nonhomologous end joining (GO:0006303)3.55928430
63non-recombinational repair (GO:0000726)3.55928430
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.54847799
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.53520844
66histone arginine methylation (GO:0034969)3.53219379
67maturation of 5.8S rRNA (GO:0000460)3.51092467
68termination of RNA polymerase II transcription (GO:0006369)3.50502990
69pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.49609841
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49380329
71DNA double-strand break processing (GO:0000729)3.45991565
72base-excision repair, AP site formation (GO:0006285)3.45920089
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45152336
74negative regulation of mRNA processing (GO:0050686)3.42575308
75sulfur amino acid catabolic process (GO:0000098)3.42011284
76DNA replication initiation (GO:0006270)3.41130124
77regulation of translational termination (GO:0006449)3.40483514
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39691606
79establishment of viral latency (GO:0019043)3.35984982
80cullin deneddylation (GO:0010388)3.34180377
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32494780
82protein targeting to ER (GO:0045047)3.30699342
83protein targeting to mitochondrion (GO:0006626)3.29736343
84kinetochore assembly (GO:0051382)3.29728184
85cotranslational protein targeting to membrane (GO:0006613)3.28862732
86ribosome assembly (GO:0042255)3.26601656
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.26378057
88guanosine-containing compound biosynthetic process (GO:1901070)3.25624192
89viral life cycle (GO:0019058)3.24867240
90cellular component biogenesis (GO:0044085)3.23143295
91positive regulation of protein oligomerization (GO:0032461)3.22157369
92peptidyl-arginine N-methylation (GO:0035246)3.21581182
93peptidyl-arginine methylation (GO:0018216)3.21581182
94rRNA transcription (GO:0009303)3.21133937
95positive regulation of developmental pigmentation (GO:0048087)3.18625086
96UTP biosynthetic process (GO:0006228)3.18055763
97DNA ligation (GO:0006266)3.17820909
98protein localization to endoplasmic reticulum (GO:0070972)3.17034445
99telomere maintenance via telomere lengthening (GO:0010833)3.16912620
100positive regulation of DNA repair (GO:0045739)3.15768217
101negative regulation of RNA splicing (GO:0033119)3.15372719
102apoptotic process involved in morphogenesis (GO:0060561)3.14974601
103mitotic recombination (GO:0006312)3.14707804
104establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14679857
105mitochondrial DNA replication (GO:0006264)3.14196970
106rRNA processing (GO:0006364)3.13727195
107negative regulation of Ras GTPase activity (GO:0034261)3.10800853
108pyrimidine nucleotide catabolic process (GO:0006244)3.10771756
109* translation (GO:0006412)3.10276068
110positive regulation by host of viral transcription (GO:0043923)3.07836179
111cellular response to ATP (GO:0071318)3.07049522
112dosage compensation (GO:0007549)3.06405632
113trophectodermal cell differentiation (GO:0001829)3.05488613
114pentose metabolic process (GO:0019321)3.04554455
115chaperone-mediated protein transport (GO:0072321)3.04413266
116cellular protein complex disassembly (GO:0043624)3.03810463
117NADH metabolic process (GO:0006734)3.03698628
118protein deneddylation (GO:0000338)3.03555526
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03536993
120mitotic metaphase plate congression (GO:0007080)3.03533805
121pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03317006
122establishment of protein localization to mitochondrion (GO:0072655)3.03097541
123nuclear envelope reassembly (GO:0031468)3.02854316
124mitotic nuclear envelope reassembly (GO:0007084)3.02854316
125DNA topological change (GO:0006265)3.01207156
126CTP metabolic process (GO:0046036)2.99328334
127CTP biosynthetic process (GO:0006241)2.99328334
128pseudouridine synthesis (GO:0001522)2.99176594
129negative regulation of protein oligomerization (GO:0032460)2.97856152
130pentose-phosphate shunt (GO:0006098)2.97336516
131labyrinthine layer development (GO:0060711)2.95706948
132meiotic chromosome segregation (GO:0045132)2.95398370
133heterochromatin organization (GO:0070828)2.95285941
134mitotic sister chromatid segregation (GO:0000070)2.94069859
135rRNA metabolic process (GO:0016072)2.93939085
136regulation of double-strand break repair (GO:2000779)2.93566789
137embryonic camera-type eye development (GO:0031076)2.93527961
138COPI coating of Golgi vesicle (GO:0048205)2.91824570
139Golgi transport vesicle coating (GO:0048200)2.91824570
140regulation of protein oligomerization (GO:0032459)2.91451880
141ribosome biogenesis (GO:0042254)2.91312300
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90537472
143histone H4-K12 acetylation (GO:0043983)2.88997183
1442-deoxyribonucleotide biosynthetic process (GO:0009265)2.88425360
145deoxyribose phosphate biosynthetic process (GO:0046385)2.88425360
146folic acid-containing compound biosynthetic process (GO:0009396)2.87995945
147negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.87846510
148UTP metabolic process (GO:0046051)2.87353073
149folic acid metabolic process (GO:0046655)2.87183020
150mitochondrial fusion (GO:0008053)2.86752936
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85501601
152L-serine metabolic process (GO:0006563)2.85484589
153positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84261804
154positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84261804
155positive regulation of mitotic sister chromatid separation (GO:1901970)2.84261804
156regulation of gene silencing by RNA (GO:0060966)2.84246288
157regulation of posttranscriptional gene silencing (GO:0060147)2.84246288
158regulation of gene silencing by miRNA (GO:0060964)2.84246288
159IMP biosynthetic process (GO:0006188)2.84060131
160protein complex disassembly (GO:0043241)2.83927264
161protein complex localization (GO:0031503)2.83674478
162translational initiation (GO:0006413)2.83543248
163purine nucleobase biosynthetic process (GO:0009113)2.83294146
164nucleobase biosynthetic process (GO:0046112)2.81613549
165alkaloid metabolic process (GO:0009820)2.81276964
166protein localization to mitochondrion (GO:0070585)2.81254953
167negative regulation of ligase activity (GO:0051352)2.80313819
168spliceosomal snRNP assembly (GO:0000387)2.79373722
169convergent extension (GO:0060026)2.79267851
170heme biosynthetic process (GO:0006783)2.77236932
171regulation of sister chromatid cohesion (GO:0007063)2.77146684
172proteasome assembly (GO:0043248)2.73872089
173nodal signaling pathway (GO:0038092)2.73756156
174proline biosynthetic process (GO:0006561)10.0294826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.68672472
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45118132
3E2F7_22180533_ChIP-Seq_HELA_Human3.24037956
4* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70655763
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.70088498
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69755955
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59397907
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.51032807
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38088592
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33603543
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29811923
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24690480
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.21912241
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.21912241
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.21912241
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20066783
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.06180638
18* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06042502
19* VDR_21846776_ChIP-Seq_THP-1_Human2.02348231
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01610274
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.99757354
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88604191
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.87699291
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.86107668
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83163676
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81722030
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.81614728
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80477655
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79675482
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77671829
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77446962
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.76396310
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72204425
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66414560
35LXR_22292898_ChIP-Seq_THP-1_Human1.66195743
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63705090
37XRN2_22483619_ChIP-Seq_HELA_Human1.61534061
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.60377183
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.60046094
40ZNF263_19887448_ChIP-Seq_K562_Human1.58755974
41* GABP_19822575_ChIP-Seq_HepG2_Human1.58508603
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.55995176
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55639227
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55076540
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54211251
46* DCP1A_22483619_ChIP-Seq_HELA_Human1.53107485
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52081725
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51969625
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51562551
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.51182463
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50760615
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49621511
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49449519
54MYC_22102868_ChIP-Seq_BL_Human1.49181152
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49163542
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.48018190
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47716630
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47384452
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45582097
60* TET1_21451524_ChIP-Seq_MESCs_Mouse1.45522624
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45344032
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44696391
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39903478
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.39871622
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38810815
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38781205
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36974119
68* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36253019
69TTF2_22483619_ChIP-Seq_HELA_Human1.35579208
70AR_21909140_ChIP-Seq_LNCAP_Human1.33019993
71* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30547175
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30204038
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29328531
74FOXP3_21729870_ChIP-Seq_TREG_Human1.28744354
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.28199888
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27594933
77* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26493258
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.26126454
79* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25976276
80KDM5A_27292631_Chip-Seq_BREAST_Human1.25497320
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24617916
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23391041
83RACK7_27058665_Chip-Seq_MCF-7_Human1.23085660
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23031591
85* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22092010
86P68_20966046_ChIP-Seq_HELA_Human1.22073675
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21852747
88CIITA_25753668_ChIP-Seq_RAJI_Human1.20343541
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19248300
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19203573
91* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19192326
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18932112
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18810573
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18093351
95* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18018192
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16671434
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16555710
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16525359
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15893075
100RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14872249
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14345786
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13838854
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.13552025
104* VDR_23849224_ChIP-Seq_CD4+_Human1.13287409
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13265076
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13048763
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11876282
108* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09751693
109* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09380250
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08930795
111* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08806678
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.07704021
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07506468
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.07448390
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07398226
116* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07332416
117SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06969469
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06176579
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06067625
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.05920164
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05644322
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.05431381
123* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05338662
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03947281
125TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03657523
126TFEB_21752829_ChIP-Seq_HELA_Human1.03517666
127FOXP1_21924763_ChIP-Seq_HESCs_Human1.03055480
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.03018687
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02829215
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01635514
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01467250
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01300868
133CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01096836
134* E2F1_21310950_ChIP-Seq_MCF-7_Human1.00689627
135BCOR_27268052_Chip-Seq_Bcells_Human0.98959239
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98948976
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98522984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.00562710
2MP0009278_abnormal_bone_marrow3.84368713
3MP0005451_abnormal_body_composition3.78719186
4MP0005171_absent_coat_pigmentation3.40374035
5MP0010030_abnormal_orbit_morphology3.38892178
6MP0004233_abnormal_muscle_weight3.15154237
7MP0010094_abnormal_chromosome_stability2.78680533
8MP0004957_abnormal_blastocyst_morpholog2.74531833
9MP0002877_abnormal_melanocyte_morpholog2.69874645
10MP0002009_preneoplasia2.44370660
11MP0008995_early_reproductive_senescence2.42527428
12MP0003693_abnormal_embryo_hatching2.32641144
13MP0004185_abnormal_adipocyte_glucose2.25390278
14MP0005085_abnormal_gallbladder_physiolo2.22699372
15MP0003786_premature_aging2.14309270
16MP0003111_abnormal_nucleus_morphology2.13997781
17MP0005397_hematopoietic_system_phenotyp2.09773044
18MP0001545_abnormal_hematopoietic_system2.09773044
19MP0008007_abnormal_cellular_replicative2.06573852
20MP0003806_abnormal_nucleotide_metabolis2.05820613
21MP0003890_abnormal_embryonic-extraembry2.04962769
22MP0004133_heterotaxia1.97950701
23MP0008932_abnormal_embryonic_tissue1.93339465
24MP0009379_abnormal_foot_pigmentation1.90641380
25MP0000678_abnormal_parathyroid_gland1.84651911
26MP0005365_abnormal_bile_salt1.84500991
27MP0008260_abnormal_autophagy1.84345152
28MP0008058_abnormal_DNA_repair1.83491052
29MP0003283_abnormal_digestive_organ1.82423129
30MP0003119_abnormal_digestive_system1.82028153
31MP0003567_abnormal_fetal_cardiomyocyte1.76527223
32MP0003077_abnormal_cell_cycle1.76466417
33MP0006035_abnormal_mitochondrial_morpho1.76123366
34MP0001661_extended_life_span1.72233642
35MP0002653_abnormal_ependyma_morphology1.71624555
36MP0005670_abnormal_white_adipose1.70608323
37MP0002269_muscular_atrophy1.69347011
38MP0003705_abnormal_hypodermis_morpholog1.66666179
39MP0001697_abnormal_embryo_size1.64961180
40MP0002249_abnormal_larynx_morphology1.60631877
41MP0002086_abnormal_extraembryonic_tissu1.55693325
42MP0005330_cardiomyopathy1.53099062
43MP0006072_abnormal_retinal_apoptosis1.50074658
44MP0004858_abnormal_nervous_system1.49909717
45MP0000490_abnormal_crypts_of1.49826345
46MP0005174_abnormal_tail_pigmentation1.49260564
47MP0010352_gastrointestinal_tract_polyps1.48615232
48MP0003315_abnormal_perineum_morphology1.47995217
49MP0002084_abnormal_developmental_patter1.43607233
50MP0001730_embryonic_growth_arrest1.43300364
51MP0000358_abnormal_cell_content/1.42495121
52MP0002282_abnormal_trachea_morphology1.42461804
53MP0001346_abnormal_lacrimal_gland1.40734472
54MP0003718_maternal_effect1.39764441
55MP0002085_abnormal_embryonic_tissue1.39738714
56MP0004197_abnormal_fetal_growth/weight/1.39503283
57MP0003453_abnormal_keratinocyte_physiol1.39193076
58MP0003123_paternal_imprinting1.38126224
59MP0005380_embryogenesis_phenotype1.37284961
60MP0001672_abnormal_embryogenesis/_devel1.37284961
61MP0001293_anophthalmia1.35645154
62MP0000750_abnormal_muscle_regeneration1.34078430
63MP0008877_abnormal_DNA_methylation1.32961990
64MP0005266_abnormal_metabolism1.32578402
65MP0005623_abnormal_meninges_morphology1.32417941
66MP0005666_abnormal_adipose_tissue1.29625791
67MP0009672_abnormal_birth_weight1.28767145
68MP0006036_abnormal_mitochondrial_physio1.27901485
69MP0003137_abnormal_impulse_conducting1.24401172
70MP0000350_abnormal_cell_proliferation1.21589532
71MP0000579_abnormal_nail_morphology1.20234489
72MP0005360_urolithiasis1.19403511
73MP0003656_abnormal_erythrocyte_physiolo1.18795734
74MP0000537_abnormal_urethra_morphology1.18430611
75MP0005076_abnormal_cell_differentiation1.17973722
76MP0003828_pulmonary_edema1.17498374
77MP0005075_abnormal_melanosome_morpholog1.15964878
78MP0002080_prenatal_lethality1.15587926
79MP0001849_ear_inflammation1.13953893
80MP0000759_abnormal_skeletal_muscle1.12932074
81MP0000371_diluted_coat_color1.11868506
82MP0003984_embryonic_growth_retardation1.11097456
83MP0002796_impaired_skin_barrier1.10539066
84MP0000747_muscle_weakness1.09845964
85MP0000003_abnormal_adipose_tissue1.09444543
86MP0002111_abnormal_tail_morphology1.07649758
87MP0002019_abnormal_tumor_incidence1.06681220
88MP0002088_abnormal_embryonic_growth/wei1.06424578
89MP0000733_abnormal_muscle_development1.04417778
90MP0000470_abnormal_stomach_morphology1.03832556
91MP0010234_abnormal_vibrissa_follicle1.03614354
92MP0005058_abnormal_lysosome_morphology1.01804805
93MP0000462_abnormal_digestive_system1.01680036
94MP0002163_abnormal_gland_morphology1.01584546
95MP0004019_abnormal_vitamin_homeostasis1.00580813
96MP0005375_adipose_tissue_phenotype0.99282803
97MP0010630_abnormal_cardiac_muscle0.98211639
98MP0000639_abnormal_adrenal_gland0.97935731
99MP0000751_myopathy0.97437370
100MP0003221_abnormal_cardiomyocyte_apopto0.97194635
101MP0009053_abnormal_anal_canal0.95906481
102MP0005257_abnormal_intraocular_pressure0.91801351
103MP0000858_altered_metastatic_potential0.91303501
104MP0000749_muscle_degeneration0.90581411
105MP0002139_abnormal_hepatobiliary_system0.88853671
106MP0000015_abnormal_ear_pigmentation0.88129393
107MP0005332_abnormal_amino_acid0.88083120
108MP0000681_abnormal_thyroid_gland0.87576408
109MP0005384_cellular_phenotype0.87393935
110MP0000313_abnormal_cell_death0.85673640
111MP0001881_abnormal_mammary_gland0.85617574
112MP0002332_abnormal_exercise_endurance0.85287828
113MP0005501_abnormal_skin_physiology0.84865144
114MP0000762_abnormal_tongue_morphology0.84805586
115MP0009115_abnormal_fat_cell0.84013386
116MP0002089_abnormal_postnatal_growth/wei0.82702569
117MP0001340_abnormal_eyelid_morphology0.81005266
118MP0003172_abnormal_lysosome_physiology0.80426662
119MP0005621_abnormal_cell_physiology0.80266412
120MP0009697_abnormal_copulation0.78772538
121MP0002396_abnormal_hematopoietic_system0.77997013
122MP0003186_abnormal_redox_activity0.76715884
123MP0002932_abnormal_joint_morphology0.76365093
124MP0004808_abnormal_hematopoietic_stem0.75171297
125MP0002160_abnormal_reproductive_system0.73926842
126MP0009333_abnormal_splenocyte_physiolog0.73668079
127MP0004782_abnormal_surfactant_physiolog0.73103518
128MP0001764_abnormal_homeostasis0.71875431
129MP0004087_abnormal_muscle_fiber0.70970561
130MP0001853_heart_inflammation0.70238952
131MP0005376_homeostasis/metabolism_phenot0.69629658
132MP0009840_abnormal_foam_cell0.68777195
133MP0002970_abnormal_white_adipose0.68383286
134MP0003191_abnormal_cellular_cholesterol0.68049981
135MP0004142_abnormal_muscle_tone0.65869341
136MP0001727_abnormal_embryo_implantation0.65658833
137MP0002114_abnormal_axial_skeleton0.65300889
138MP0001145_abnormal_male_reproductive0.65279344
139MP0002075_abnormal_coat/hair_pigmentati0.64823629
140MP0010307_abnormal_tumor_latency0.64629411
141MP0005319_abnormal_enzyme/_coenzyme0.64457517
142MP0002234_abnormal_pharynx_morphology0.62532723
143MP0002106_abnormal_muscle_physiology0.61733310
144MP0003566_abnormal_cell_adhesion0.61307951
145MP0002060_abnormal_skin_morphology0.61185327
146MP0002132_abnormal_respiratory_system0.61067264
147MP0004264_abnormal_extraembryonic_tissu0.59872450

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.11267895
2Rib fusion (HP:0000902)4.83486506
3Rectovaginal fistula (HP:0000143)4.63089914
4Rectal fistula (HP:0100590)4.63089914
5Pustule (HP:0200039)4.56282310
6Annular pancreas (HP:0001734)4.38593356
7Abnormal hemoglobin (HP:0011902)4.27019001
8Facial hemangioma (HP:0000329)4.26806343
9Vaginal fistula (HP:0004320)4.18863638
10Poikiloderma (HP:0001029)4.14261726
11Increased IgM level (HP:0003496)4.13609271
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.13504769
13Ragged-red muscle fibers (HP:0003200)4.00014210
14Intestinal fistula (HP:0100819)3.98979570
15Alopecia of scalp (HP:0002293)3.94016155
16Turricephaly (HP:0000262)3.85144757
17Tongue fasciculations (HP:0001308)3.84990731
18Microvesicular hepatic steatosis (HP:0001414)3.68973276
19Muscle fibrillation (HP:0010546)3.66682140
20Hypochromic microcytic anemia (HP:0004840)3.66496036
21Abnormality of glycolysis (HP:0004366)3.51328368
22Aplasia/hypoplasia of the humerus (HP:0006507)3.46560098
23Ulnar bowing (HP:0003031)3.44726796
24Short humerus (HP:0005792)3.35470202
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22462968
26Male infertility (HP:0003251)3.21955054
27Absent radius (HP:0003974)3.20395162
28Absent thumb (HP:0009777)3.16006324
29Coronal craniosynostosis (HP:0004440)3.15703755
30Increased serum pyruvate (HP:0003542)3.13410199
31Trismus (HP:0000211)3.12044885
32Abnormal mitochondria in muscle tissue (HP:0008316)3.10377682
33Diaphragmatic weakness (HP:0009113)3.07268182
34Multiple enchondromatosis (HP:0005701)3.02320984
35Microretrognathia (HP:0000308)3.01942078
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.99942382
37Vertebral hypoplasia (HP:0008417)2.99942382
38Aplasia involving forearm bones (HP:0009822)2.98712815
39Absent forearm bone (HP:0003953)2.98712815
40Orthostatic hypotension (HP:0001278)2.97558957
41Reticulocytopenia (HP:0001896)2.97455219
42Squamous cell carcinoma (HP:0002860)2.91421075
43Increased intramyocellular lipid droplets (HP:0012240)2.91228747
44Abnormality of the aortic arch (HP:0012303)2.90519892
45Myopathic facies (HP:0002058)2.90009279
46Abnormality of male internal genitalia (HP:0000022)2.88532666
47Achilles tendon contracture (HP:0001771)2.87250990
48Testicular atrophy (HP:0000029)2.85855221
49Abnormal gallbladder physiology (HP:0012438)2.85541315
50Cholecystitis (HP:0001082)2.85541315
51Hepatocellular necrosis (HP:0001404)2.83972272
52Pancreatic islet-cell hyperplasia (HP:0004510)2.82744901
53Large for gestational age (HP:0001520)2.82589329
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82327947
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82327947
56Patellar aplasia (HP:0006443)2.81465803
57Intestinal atresia (HP:0011100)2.79943129
58Exertional dyspnea (HP:0002875)2.79572545
59Increased muscle lipid content (HP:0009058)2.75612122
60Acute necrotizing encephalopathy (HP:0006965)2.74750787
61Polycythemia (HP:0001901)2.73920391
62Congenital hip dislocation (HP:0001374)2.73305580
63Short chin (HP:0000331)2.71354321
64Abnormality of the umbilical cord (HP:0010881)2.68850603
65Hepatic necrosis (HP:0002605)2.67221559
66Rough bone trabeculation (HP:0100670)2.65909558
67Selective tooth agenesis (HP:0001592)2.64863951
68Increased CSF lactate (HP:0002490)2.62113250
69Acute encephalopathy (HP:0006846)2.61886678
70Aplasia/Hypoplasia of the patella (HP:0006498)2.61765139
71Premature skin wrinkling (HP:0100678)2.61158499
72Exercise intolerance (HP:0003546)2.59678188
73Increased serum lactate (HP:0002151)2.59620117
74Reduced antithrombin III activity (HP:0001976)2.58722868
75Mitochondrial inheritance (HP:0001427)2.58629943
76Basal cell carcinoma (HP:0002671)2.58314455
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58010115
78Broad distal phalanx of finger (HP:0009836)2.57600625
79Abnormality of the Achilles tendon (HP:0005109)2.56430016
80Premature graying of hair (HP:0002216)2.50295099
81Hypokinesia (HP:0002375)2.49048615
82Urinary glycosaminoglycan excretion (HP:0003541)2.48295618
83Mucopolysacchariduria (HP:0008155)2.48295618
84Anteriorly placed anus (HP:0001545)2.46874154
85Redundant skin (HP:0001582)2.46069993
86Broad alveolar ridges (HP:0000187)2.45690970
87Lactic acidosis (HP:0003128)2.44976665
88Hypochromic anemia (HP:0001931)2.44142403
89Type I transferrin isoform profile (HP:0003642)2.43919894
90Choanal stenosis (HP:0000452)2.43578868
91Rhabdomyolysis (HP:0003201)2.40712497
92Dysautonomia (HP:0002459)2.39843889
93Albinism (HP:0001022)2.37494472
94Hamartoma (HP:0010566)2.35480453
95Hypotrichosis (HP:0001006)2.33589466
96Abnormality of the fetal cardiovascular system (HP:0010948)2.33185649
97Abnormal umbilical cord blood vessels (HP:0011403)2.33185649
98Single umbilical artery (HP:0001195)2.33185649
99Hypobetalipoproteinemia (HP:0003563)2.33171191
100Asymmetric septal hypertrophy (HP:0001670)2.32461351
101Alacrima (HP:0000522)2.32390616
102Growth hormone excess (HP:0000845)2.32023727
103Birth length less than 3rd percentile (HP:0003561)2.31790711
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.28794985
105Hypoplasia of the radius (HP:0002984)2.27378236
106Vertebral compression fractures (HP:0002953)2.26977823
107Hyperacusis (HP:0010780)2.26920756
108Joint stiffness (HP:0001387)2.25701737
109Aplasia of the musculature (HP:0100854)2.23168971
110Abnormality of placental membranes (HP:0011409)2.22570357
111Amniotic constriction ring (HP:0009775)2.22570357
112Distal lower limb muscle weakness (HP:0009053)2.21553450
113Breast hypoplasia (HP:0003187)2.21469627
114Cerebral edema (HP:0002181)2.20998481
115Macrocytic anemia (HP:0001972)2.19056458
116Abnormality of cells of the erythroid lineage (HP:0012130)2.17486214
117Gout (HP:0001997)2.16616538
118Progressive external ophthalmoplegia (HP:0000590)2.16472591
119Generalized amyotrophy (HP:0003700)2.15703719
120Abnormal number of erythroid precursors (HP:0012131)2.13651366
121Capillary hemangiomas (HP:0005306)2.13330989
122Bifid uvula (HP:0000193)2.13151273
123Ketoacidosis (HP:0001993)2.12341064
124Abnormality of polysaccharide metabolism (HP:0011012)2.12151224
125Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12151224
126Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12151224
127Muscle fiber atrophy (HP:0100295)2.07824322
128Increased hepatocellular lipid droplets (HP:0006565)2.05287286
129Dysostosis multiplex (HP:0000943)2.04902047
130Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04034588
131IgA deficiency (HP:0002720)2.03272550
132Hyperammonemia (HP:0001987)2.00935512
133Exercise-induced myalgia (HP:0003738)1.99731428
134Abnormality of reticulocytes (HP:0004312)1.98718901
135Bulbar palsy (HP:0001283)1.96173206
136Abnormalities of placenta or umbilical cord (HP:0001194)1.95834421
137Opisthotonus (HP:0002179)1.95275372
138Lipid accumulation in hepatocytes (HP:0006561)1.94691331
139Abnormality of the labia minora (HP:0012880)1.94689704
140Vertebral fusion (HP:0002948)1.93221380
141Abnormal trabecular bone morphology (HP:0100671)1.92481484
142Septate vagina (HP:0001153)1.92191844
143Insomnia (HP:0100785)1.91507491
144Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90665782
145Distal lower limb amyotrophy (HP:0008944)1.89710601
146Hyperglycinuria (HP:0003108)1.87124564
147Abnormality of the pancreatic islet cells (HP:0006476)1.86446111
148Abnormality of endocrine pancreas physiology (HP:0012093)1.86446111
149Renal Fanconi syndrome (HP:0001994)1.85688747
150Truncus arteriosus (HP:0001660)1.85668452
151Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85606126
152Fasciculations (HP:0002380)1.84997004
153Popliteal pterygium (HP:0009756)1.84716357
154Proximal placement of thumb (HP:0009623)1.84207155
155Premature ovarian failure (HP:0008209)1.83492517
156Aplastic anemia (HP:0001915)1.82469811
157Progressive muscle weakness (HP:0003323)1.82375845
158Abnormal number of incisors (HP:0011064)1.82094125
159Hypotelorism (HP:0000601)1.82080166
160Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81813940
161Abnormal protein N-linked glycosylation (HP:0012347)1.81813940
162Abnormal protein glycosylation (HP:0012346)1.81813940
163Abnormal glycosylation (HP:0012345)1.81813940
164Type 2 muscle fiber atrophy (HP:0003554)1.81404188
165Progressive macrocephaly (HP:0004481)1.80769340
166Secondary amenorrhea (HP:0000869)1.80459292
167Cerebral hypomyelination (HP:0006808)1.79030546
168Myoglobinuria (HP:0002913)1.78943359
169Bowing of the arm (HP:0006488)1.78276634
170Bowed forearm bones (HP:0003956)1.78276634
171Increased connective tissue (HP:0009025)1.78244873
172Hypertensive crisis (HP:0100735)1.77744258
173Cholelithiasis (HP:0001081)1.77518587
174Spastic paraparesis (HP:0002313)1.77415664
175Pallor (HP:0000980)1.76930476
176Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76858774
177Hypergonadotropic hypogonadism (HP:0000815)1.76639982
178Abnormality of the distal phalanges of the toes (HP:0010182)1.76269222
179Respiratory difficulties (HP:0002880)1.76212575
180Nemaline bodies (HP:0003798)1.75355587
181Reduced subcutaneous adipose tissue (HP:0003758)1.74369188
182Respiratory failure (HP:0002878)1.74356859
183Muscle fiber inclusion bodies (HP:0100299)1.71546101
184Abnormality of the tricuspid valve (HP:0001702)1.71149490
185Deviation of the thumb (HP:0009603)1.71145268
186Sparse eyelashes (HP:0000653)1.69203432
187Neoplasm of head and neck (HP:0012288)1.68653929
188Esophageal neoplasm (HP:0100751)1.68653929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.56612527
2MAPK154.85805645
3DDR24.45961972
4VRK24.20381066
5MAP3K64.16200206
6MAP3K113.95641994
7SMG13.28313201
8PINK13.27790459
9PIM22.71337620
10IRAK32.68372687
11MATK2.63962819
12FGR2.40985143
13TYRO32.38731382
14DAPK12.36181286
15TESK12.27060250
16UHMK12.24745734
17ARAF2.18746630
18BMX2.00687685
19CDK71.94711620
20DYRK1B1.89422967
21YES11.88517887
22CSK1.87358906
23EEF2K1.87192194
24PBK1.86690099
25PRKD21.78742139
26STK161.75016099
27SRPK11.74715682
28SCYL21.72529949
29PDGFRA1.63032779
30LATS21.51387501
31ERN11.46753716
32PIM11.45055277
33LIMK11.44275130
34BRAF1.41456431
35BCKDK1.40601679
36BUB11.39778949
37MAP3K101.38957660
38RPS6KC11.35214472
39RPS6KL11.35214472
40CDK61.33054379
41WEE11.26748886
42AKT31.24417815
43CDK121.23577754
44NME21.22902369
45PHKG21.22464667
46PHKG11.22464667
47MAPK111.21311788
48TTN1.19860328
49NEK11.19724427
50RPS6KA61.18005452
51DYRK31.14743631
52PLK11.12005070
53MST1R1.11243605
54ABL21.11052942
55TRPM71.06818548
56CHEK21.04501063
57CDC42BPA1.03732640
58LRRK20.96839534
59PDK20.96699672
60GSK3A0.96306895
61TLK10.95736389
62BRSK10.95566822
63SIK10.90230133
64TRIB30.85415386
65TAOK20.84220687
66MAP2K30.80866120
67PRKD30.80445719
68CDC70.78249079
69AURKA0.77600991
70NEK20.76406299
71RPS6KB20.73987909
72VRK10.72980635
73STK40.72470743
74RPS6KA10.71228111
75EPHA20.64945571
76ATR0.64011193
77TSSK60.63953182
78MAP2K20.63349466
79PRKAA10.62339262
80CSNK2A10.61691004
81MTOR0.61001828
82PLK40.60005146
83DAPK30.57234404
84RAF10.54783931
85AURKB0.54540173
86TAF10.53050780
87EIF2AK10.52950675
88CCNB10.52680482
89LMTK20.52438263
90STK100.52074126
91PKN20.51930973
92CDK20.51592145
93CDK40.49489501
94CSNK2A20.48250952
95CDK90.46751251
96CSNK1G30.46157835
97RPS6KA40.46148799
98MAPKAPK30.45948659
99STK38L0.45615890
100TESK20.44511342
101CAMK2G0.44464282
102PTK20.44069994
103TTK0.44069735
104CDK190.43034572
105MAPK40.41113041
106MUSK0.40973336
107IRAK20.39588613
108HIPK20.39231849
109CDK150.38827310
110DYRK20.37800737
111ALK0.35469990
112CDK140.35457730
113CDK180.34604618
114CHEK10.34219955
115PAK10.33254913
116PLK30.33248422
117RPS6KB10.32451000
118MAP3K10.32355532
119MAP3K80.32340991
120EGFR0.32120286
121TAOK10.31462187
122LYN0.31385211
123PAK40.31080484
124MAP3K30.29836000
125CAMK2B0.29332035
126BRSK20.28978560
127MOS0.28699349
128PDK30.28539529
129PDK40.28539529
130DMPK0.27981081
131MAPK30.27728371
132ATM0.25956589
133ILK0.25377961
134PRPF4B0.24868254
135AKT20.24787541
136ACVR1B0.24080675
137MAPK10.24016771
138MAPKAPK20.23830040
139KDR0.23599832
140CDK10.22806014
141CDK11A0.22161611
142CAMK2D0.22066145
143FLT30.21604558
144CSNK1G10.21008432
145PRKAA20.20867736
146NME10.18926733
147PRKCI0.17991817
148MAPK140.17678541
149CDK80.17242262

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.61583214
2DNA replication_Homo sapiens_hsa030304.11449910
3Base excision repair_Homo sapiens_hsa034104.10448309
4Fatty acid biosynthesis_Homo sapiens_hsa000613.77375971
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.79422756
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39205132
7* Ribosome_Homo sapiens_hsa030102.36705197
8Nucleotide excision repair_Homo sapiens_hsa034202.35648090
9Sulfur relay system_Homo sapiens_hsa041222.34741111
10Spliceosome_Homo sapiens_hsa030402.23533377
11Biosynthesis of amino acids_Homo sapiens_hsa012302.18444502
12RNA transport_Homo sapiens_hsa030132.01551869
13Arginine and proline metabolism_Homo sapiens_hsa003302.01498594
14Homologous recombination_Homo sapiens_hsa034402.00415269
15Folate biosynthesis_Homo sapiens_hsa007901.81478878
16Proteasome_Homo sapiens_hsa030501.77303530
17Fatty acid metabolism_Homo sapiens_hsa012121.74211551
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67001183
19One carbon pool by folate_Homo sapiens_hsa006701.50073290
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48877301
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48470594
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45019146
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44339238
24mRNA surveillance pathway_Homo sapiens_hsa030151.43569614
25Fanconi anemia pathway_Homo sapiens_hsa034601.41477001
26RNA polymerase_Homo sapiens_hsa030201.37456238
27Arginine biosynthesis_Homo sapiens_hsa002201.36900937
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33755913
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33080773
30Parkinsons disease_Homo sapiens_hsa050121.26888206
31Vitamin B6 metabolism_Homo sapiens_hsa007501.24052338
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23230374
33Fructose and mannose metabolism_Homo sapiens_hsa000511.23051722
34Cell cycle_Homo sapiens_hsa041101.22644779
35Oxidative phosphorylation_Homo sapiens_hsa001901.18948636
36p53 signaling pathway_Homo sapiens_hsa041151.18242091
37Carbon metabolism_Homo sapiens_hsa012001.17370050
38Pyrimidine metabolism_Homo sapiens_hsa002401.16407405
39Purine metabolism_Homo sapiens_hsa002301.12691891
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.12311467
41Glutathione metabolism_Homo sapiens_hsa004801.04710019
42Huntingtons disease_Homo sapiens_hsa050161.03015277
43Hippo signaling pathway_Homo sapiens_hsa043901.02766035
44Non-homologous end-joining_Homo sapiens_hsa034501.02686240
45Hedgehog signaling pathway_Homo sapiens_hsa043401.02304486
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.99585838
47Notch signaling pathway_Homo sapiens_hsa043300.97074297
48Propanoate metabolism_Homo sapiens_hsa006400.95395430
49mTOR signaling pathway_Homo sapiens_hsa041500.95179112
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93473926
51Circadian rhythm_Homo sapiens_hsa047100.93152338
52N-Glycan biosynthesis_Homo sapiens_hsa005100.91606295
53Bladder cancer_Homo sapiens_hsa052190.88171586
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87319585
55Pyruvate metabolism_Homo sapiens_hsa006200.87101422
56Lysine degradation_Homo sapiens_hsa003100.86262673
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.85241493
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81081085
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80173408
60Sulfur metabolism_Homo sapiens_hsa009200.80088775
61Galactose metabolism_Homo sapiens_hsa000520.74865609
62Selenocompound metabolism_Homo sapiens_hsa004500.74712557
63Fatty acid degradation_Homo sapiens_hsa000710.73133536
64Cardiac muscle contraction_Homo sapiens_hsa042600.71713431
65Fatty acid elongation_Homo sapiens_hsa000620.70331741
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.69970140
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68859209
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67921145
69Tyrosine metabolism_Homo sapiens_hsa003500.67767845
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66829906
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64981462
72Adherens junction_Homo sapiens_hsa045200.63291053
73Other glycan degradation_Homo sapiens_hsa005110.59097527
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59056459
75TGF-beta signaling pathway_Homo sapiens_hsa043500.58595760
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58295099
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57923637
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.56793470
79Pentose phosphate pathway_Homo sapiens_hsa000300.55148852
80RNA degradation_Homo sapiens_hsa030180.55140907
81Oocyte meiosis_Homo sapiens_hsa041140.53959070
82Tryptophan metabolism_Homo sapiens_hsa003800.53461254
83Basal cell carcinoma_Homo sapiens_hsa052170.52428726
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51324329
85Alzheimers disease_Homo sapiens_hsa050100.50637956
86Vibrio cholerae infection_Homo sapiens_hsa051100.49794026
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49103855
88Metabolic pathways_Homo sapiens_hsa011000.49052507
89Fat digestion and absorption_Homo sapiens_hsa049750.49051848
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48773987
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48425387
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.48067851
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46780685
94beta-Alanine metabolism_Homo sapiens_hsa004100.46545779
95Shigellosis_Homo sapiens_hsa051310.45784786
96Prion diseases_Homo sapiens_hsa050200.45358731
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43117578
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40523022
99Wnt signaling pathway_Homo sapiens_hsa043100.39099028
100Basal transcription factors_Homo sapiens_hsa030220.38238155
101Butanoate metabolism_Homo sapiens_hsa006500.37464406
102Peroxisome_Homo sapiens_hsa041460.36793844
103Chronic myeloid leukemia_Homo sapiens_hsa052200.35208566
104Apoptosis_Homo sapiens_hsa042100.33862517
105HTLV-I infection_Homo sapiens_hsa051660.33617455
106VEGF signaling pathway_Homo sapiens_hsa043700.32947278
107Thyroid cancer_Homo sapiens_hsa052160.32550680
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32194646
109Starch and sucrose metabolism_Homo sapiens_hsa005000.32086146
110AMPK signaling pathway_Homo sapiens_hsa041520.31089826
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28826847
112Phenylalanine metabolism_Homo sapiens_hsa003600.26589145
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26333694
114Acute myeloid leukemia_Homo sapiens_hsa052210.26020882
115Tight junction_Homo sapiens_hsa045300.25925575
116Viral myocarditis_Homo sapiens_hsa054160.25604702
117Epstein-Barr virus infection_Homo sapiens_hsa051690.25035447
118Viral carcinogenesis_Homo sapiens_hsa052030.24865170
119Legionellosis_Homo sapiens_hsa051340.22997428
120Pancreatic cancer_Homo sapiens_hsa052120.22671396
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22285311
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.21992068
123Insulin signaling pathway_Homo sapiens_hsa049100.21323437
124Primary immunodeficiency_Homo sapiens_hsa053400.20776479
125Non-small cell lung cancer_Homo sapiens_hsa052230.20475117
126Herpes simplex infection_Homo sapiens_hsa051680.20348354
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17346868
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13939160
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13490030
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13117859
131Small cell lung cancer_Homo sapiens_hsa052220.12744626

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