MRPL19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.22811301
2telomere maintenance via semi-conservative replication (GO:0032201)5.28635193
3ribosomal small subunit assembly (GO:0000028)4.85146967
4DNA strand elongation involved in DNA replication (GO:0006271)4.79147850
5telomere maintenance via recombination (GO:0000722)4.61124472
6DNA strand elongation (GO:0022616)4.60903170
7proteasome assembly (GO:0043248)4.51086967
8establishment of integrated proviral latency (GO:0075713)4.38298612
9DNA replication initiation (GO:0006270)4.34881834
10respiratory chain complex IV assembly (GO:0008535)4.30160661
11ribosome assembly (GO:0042255)4.21512243
12mitotic recombination (GO:0006312)4.07992775
13maturation of SSU-rRNA (GO:0030490)4.06084195
14telomere maintenance via telomere lengthening (GO:0010833)4.04383172
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.95403912
16mitotic metaphase plate congression (GO:0007080)3.90248517
17DNA replication checkpoint (GO:0000076)3.87051727
18pseudouridine synthesis (GO:0001522)3.86839811
19nuclear pore complex assembly (GO:0051292)3.84933507
20ribosomal small subunit biogenesis (GO:0042274)3.83372121
21viral transcription (GO:0019083)3.82380650
22nuclear pore organization (GO:0006999)3.75779599
23double-strand break repair via nonhomologous end joining (GO:0006303)3.75233123
24non-recombinational repair (GO:0000726)3.75233123
25translational termination (GO:0006415)3.73025414
26ribosomal large subunit biogenesis (GO:0042273)3.69739222
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68157904
28GDP-mannose metabolic process (GO:0019673)3.63552201
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.61974007
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.61974007
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.61974007
32regulation of sister chromatid cohesion (GO:0007063)3.60478001
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.60250378
34termination of RNA polymerase III transcription (GO:0006386)3.60250378
35cytochrome complex assembly (GO:0017004)3.58923407
36cotranslational protein targeting to membrane (GO:0006613)3.58511278
37protein localization to kinetochore (GO:0034501)3.56626014
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.56483211
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.55381857
40protein targeting to ER (GO:0045047)3.54462257
41chaperone-mediated protein transport (GO:0072321)3.51974976
42DNA unwinding involved in DNA replication (GO:0006268)3.47788363
43ribonucleoprotein complex biogenesis (GO:0022613)3.47542712
44rRNA modification (GO:0000154)3.46719979
45positive regulation of chromosome segregation (GO:0051984)3.43856014
46protein localization to chromosome, centromeric region (GO:0071459)3.42651859
47viral mRNA export from host cell nucleus (GO:0046784)3.41859719
48protein localization to endoplasmic reticulum (GO:0070972)3.38018637
49metaphase plate congression (GO:0051310)3.36198761
50translational elongation (GO:0006414)3.33556831
51transcription-coupled nucleotide-excision repair (GO:0006283)3.33509092
52tRNA methylation (GO:0030488)3.33018742
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32901382
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32741530
55mitotic sister chromatid segregation (GO:0000070)3.31382865
56CENP-A containing nucleosome assembly (GO:0034080)3.29734366
57ribosome biogenesis (GO:0042254)3.28336026
58histone exchange (GO:0043486)3.27988249
59rRNA processing (GO:0006364)3.27639445
60establishment of viral latency (GO:0019043)3.26517910
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24570609
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23741931
637-methylguanosine mRNA capping (GO:0006370)3.23616244
64translational initiation (GO:0006413)3.23154107
65formation of translation preinitiation complex (GO:0001731)3.22988757
66chromatin remodeling at centromere (GO:0031055)3.22186274
67nucleobase biosynthetic process (GO:0046112)3.21697576
68negative regulation of transcription by competitive promoter binding (GO:0010944)3.21523074
69sister chromatid segregation (GO:0000819)3.21494407
70spliceosomal snRNP assembly (GO:0000387)3.21154694
717-methylguanosine RNA capping (GO:0009452)3.20500443
72RNA capping (GO:0036260)3.20500443
73* translation (GO:0006412)3.20260670
74tRNA aminoacylation for protein translation (GO:0006418)3.19452280
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17016590
76regulation of mitochondrial translation (GO:0070129)3.16965717
77amino acid activation (GO:0043038)3.15766106
78tRNA aminoacylation (GO:0043039)3.15766106
79rRNA metabolic process (GO:0016072)3.15330351
80folic acid-containing compound biosynthetic process (GO:0009396)3.14148593
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13335213
82IMP biosynthetic process (GO:0006188)3.12616848
83mitochondrial RNA metabolic process (GO:0000959)3.12092462
84DNA replication-independent nucleosome assembly (GO:0006336)3.09982541
85DNA replication-independent nucleosome organization (GO:0034724)3.09982541
86dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.08231616
87regulation of cellular amino acid metabolic process (GO:0006521)3.06758378
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05971716
89cullin deneddylation (GO:0010388)3.04933152
90L-serine metabolic process (GO:0006563)3.04723771
91oxidative phosphorylation (GO:0006119)3.04580074
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04560701
93purine nucleobase biosynthetic process (GO:0009113)3.04489478
94cellular component biogenesis (GO:0044085)3.02895839
95negative regulation of myotube differentiation (GO:0010832)2.98903961
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98435290
97maturation of 5.8S rRNA (GO:0000460)2.98095000
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97699885
99deoxyribonucleotide biosynthetic process (GO:0009263)2.97462733
100protein deneddylation (GO:0000338)2.97048227
101DNA damage response, detection of DNA damage (GO:0042769)2.95316523
102regulation of centriole replication (GO:0046599)2.94776782
103telomere maintenance (GO:0000723)2.93915782
104telomere organization (GO:0032200)2.93596829
105DNA-dependent DNA replication (GO:0006261)2.93531595
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93063742
107establishment of protein localization to mitochondrial membrane (GO:0090151)2.93006523
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92745006
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92745006
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92745006
111rRNA methylation (GO:0031167)2.92590021
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92229155
113negative regulation of ligase activity (GO:0051352)2.92229155
114DNA ligation (GO:0006266)2.90576248
115kinetochore organization (GO:0051383)2.89918150
116viral life cycle (GO:0019058)2.89834828
117antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89331249
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89081219
119pteridine-containing compound biosynthetic process (GO:0042559)2.88499304
120IMP metabolic process (GO:0046040)2.88448123
121iron-sulfur cluster assembly (GO:0016226)2.88131550
122metallo-sulfur cluster assembly (GO:0031163)2.88131550
123pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87829744
124regulation of chromosome segregation (GO:0051983)2.87752524
125cellular protein complex disassembly (GO:0043624)2.87501912
126mitotic nuclear envelope disassembly (GO:0007077)2.86562348
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86529300
128protein prenylation (GO:0018342)2.86418026
129prenylation (GO:0097354)2.86418026
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86063802
131termination of RNA polymerase I transcription (GO:0006363)2.85686625
132RNA methylation (GO:0001510)2.83526683
133transcription from mitochondrial promoter (GO:0006390)2.83058939
134signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82967689
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82967689
136nucleobase-containing small molecule interconversion (GO:0015949)2.82642441
137deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82594396
138DNA catabolic process, exonucleolytic (GO:0000738)2.81463167
139transcription elongation from RNA polymerase I promoter (GO:0006362)2.81390601
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80491248
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80491248
142intra-S DNA damage checkpoint (GO:0031573)2.80436270
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.79836013
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79836013
145pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79779429
146kinetochore assembly (GO:0051382)2.78193514
147DNA replication-dependent nucleosome assembly (GO:0006335)2.78010709
148DNA replication-dependent nucleosome organization (GO:0034723)2.78010709
149signal transduction involved in cell cycle checkpoint (GO:0072395)2.77954109
150tRNA modification (GO:0006400)2.77713844
151regulation of translational fidelity (GO:0006450)2.77407719
152pore complex assembly (GO:0046931)2.77200117
153ATP synthesis coupled proton transport (GO:0015986)2.73613276
154energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73613276
155protein targeting to mitochondrion (GO:0006626)2.73021536
156mitotic sister chromatid cohesion (GO:0007064)2.71993270
157establishment of chromosome localization (GO:0051303)2.71316500
158tetrahydrofolate metabolic process (GO:0046653)2.71078809
159positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70847654
160regulation of mitotic sister chromatid separation (GO:0010965)2.70528786
161regulation of mitotic sister chromatid segregation (GO:0033047)2.70528786
162regulation of sister chromatid segregation (GO:0033045)2.70528786
163spindle checkpoint (GO:0031577)2.69986276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.55021867
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27574704
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.27236474
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.92333082
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86300045
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.58488220
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54924342
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35341223
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32818932
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27431110
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17401940
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12867224
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08331802
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80571538
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79198048
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73328766
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70658878
18* VDR_23849224_ChIP-Seq_CD4+_Human2.58188937
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57779564
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53829993
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36119961
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36096265
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26455018
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.22954952
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.20188300
26* YY1_21170310_ChIP-Seq_MESCs_Mouse2.16318578
27DCP1A_22483619_ChIP-Seq_HELA_Human2.13429400
28XRN2_22483619_ChIP-Seq_HELA_Human2.09999942
29* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09469354
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08098050
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07883243
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.07697434
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06720000
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98535218
35ELK1_19687146_ChIP-ChIP_HELA_Human1.96122197
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93926261
37GABP_19822575_ChIP-Seq_HepG2_Human1.93186949
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91170473
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89761971
40TTF2_22483619_ChIP-Seq_HELA_Human1.87502306
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86790293
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.84284417
43CIITA_25753668_ChIP-Seq_RAJI_Human1.70599643
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70528019
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68725938
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68224368
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.67514326
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65953375
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65531122
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63476724
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60788003
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59102822
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.52042780
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51086008
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46531001
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46031693
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45439715
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43585089
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43182028
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.42967715
61* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39681367
62SPI1_23547873_ChIP-Seq_NB4_Human1.38097628
63EWS_26573619_Chip-Seq_HEK293_Human1.31385198
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30653205
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27708024
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.24812014
67EZH2_22144423_ChIP-Seq_EOC_Human1.24271768
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23962278
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23563767
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23510072
71MYC_18940864_ChIP-ChIP_HL60_Human1.23202740
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21582450
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21510979
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19852004
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.18770764
76IRF1_19129219_ChIP-ChIP_H3396_Human1.16959263
77ZNF263_19887448_ChIP-Seq_K562_Human1.15100235
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15051722
79* FUS_26573619_Chip-Seq_HEK293_Human1.13154376
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12983396
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12396545
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.10090602
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07777679
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07686429
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02482307
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01953581
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.00874994
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00815297
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00607492
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00070178
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99236506
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.98314256
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96389969
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.95770200
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94886123
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94768604
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94630941
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92743408
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92284803
100KDM5A_27292631_Chip-Seq_BREAST_Human0.90792283
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90325078
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89814098
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89464826
104MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89013171
105IRF8_21731497_ChIP-ChIP_J774_Mouse0.88997650
106SCL_19346495_ChIP-Seq_HPC-7_Human0.86654750
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.85841587
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83293667
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82321350
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82177499
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81937059
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80214377
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80170895
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80074915
115AR_21909140_ChIP-Seq_LNCAP_Human0.79312346
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79170231
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79038355
118IGF1R_20145208_ChIP-Seq_DFB_Human0.78099956
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76932757
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76617247
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.76067281
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75940641
123TAF15_26573619_Chip-Seq_HEK293_Human0.75110540
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75108852
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74835539
126VDR_22108803_ChIP-Seq_LS180_Human0.74201969
127TFEB_21752829_ChIP-Seq_HELA_Human0.74156046
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74155785
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74078226
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.73419279
131VDR_21846776_ChIP-Seq_THP-1_Human0.73283272
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71966923
133CHD1_26751641_Chip-Seq_LNCaP_Human0.70819596
134MYC_22102868_ChIP-Seq_BL_Human0.70109095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58421217
2MP0009379_abnormal_foot_pigmentation4.04686606
3MP0006292_abnormal_olfactory_placode4.00760693
4MP0008058_abnormal_DNA_repair3.60403200
5MP0010094_abnormal_chromosome_stability3.33427658
6MP0003111_abnormal_nucleus_morphology3.09769794
7MP0001188_hyperpigmentation3.07565677
8MP0005174_abnormal_tail_pigmentation2.97041680
9MP0000015_abnormal_ear_pigmentation2.91491144
10MP0003941_abnormal_skin_development2.79954386
11MP0004957_abnormal_blastocyst_morpholog2.73186115
12MP0008057_abnormal_DNA_replication2.56739356
13MP0002396_abnormal_hematopoietic_system2.55004512
14MP0003077_abnormal_cell_cycle2.50540104
15MP0005075_abnormal_melanosome_morpholog2.30408159
16MP0005409_darkened_coat_color2.24856134
17MP0008007_abnormal_cellular_replicative2.13674177
18MP0003786_premature_aging2.12030951
19MP0002095_abnormal_skin_pigmentation1.97981859
20MP0008260_abnormal_autophagy1.96672778
21MP0001986_abnormal_taste_sensitivity1.96480767
22MP0000490_abnormal_crypts_of1.95901043
23MP0003646_muscle_fatigue1.91201608
24MP0003763_abnormal_thymus_physiology1.88365019
25MP0001835_abnormal_antigen_presentation1.84377642
26MP0008932_abnormal_embryonic_tissue1.84201198
27MP0000372_irregular_coat_pigmentation1.80415895
28MP0001730_embryonic_growth_arrest1.78402660
29MP0009333_abnormal_splenocyte_physiolog1.76416833
30MP0003724_increased_susceptibility_to1.71371367
31MP0001293_anophthalmia1.70062310
32MP0003136_yellow_coat_color1.62197746
33MP0003937_abnormal_limbs/digits/tail_de1.61038366
34MP0003890_abnormal_embryonic-extraembry1.60013070
35MP0005671_abnormal_response_to1.54476239
36MP0001672_abnormal_embryogenesis/_devel1.53850013
37MP0005380_embryogenesis_phenotype1.53850013
38MP0009785_altered_susceptibility_to1.52185725
39MP0001697_abnormal_embryo_size1.50712285
40MP0002876_abnormal_thyroid_physiology1.49228792
41MP0000566_synostosis1.46252212
42MP0002148_abnormal_hypersensitivity_rea1.45578750
43MP0001853_heart_inflammation1.45311215
44MP0002132_abnormal_respiratory_system1.42334746
45MP0002638_abnormal_pupillary_reflex1.42271205
46MP0003984_embryonic_growth_retardation1.41167436
47MP0003718_maternal_effect1.40874419
48MP0002697_abnormal_eye_size1.39358391
49MP0002088_abnormal_embryonic_growth/wei1.37964373
50MP0000681_abnormal_thyroid_gland1.37685918
51MP0010352_gastrointestinal_tract_polyps1.36970184
52MP0001529_abnormal_vocalization1.36610646
53MP0002084_abnormal_developmental_patter1.34874963
54MP0000678_abnormal_parathyroid_gland1.34351064
55MP0002751_abnormal_autonomic_nervous1.34140454
56MP0002234_abnormal_pharynx_morphology1.33926826
57MP0005408_hypopigmentation1.33363511
58MP0003567_abnormal_fetal_cardiomyocyte1.31279243
59MP0002085_abnormal_embryonic_tissue1.30696729
60MP0001286_abnormal_eye_development1.29964740
61MP0002398_abnormal_bone_marrow1.28317705
62MP0003806_abnormal_nucleotide_metabolis1.25987958
63MP0002233_abnormal_nose_morphology1.25444923
64MP0005025_abnormal_response_to1.25133412
65MP0009672_abnormal_birth_weight1.24198337
66MP0002080_prenatal_lethality1.23670108
67MP0004147_increased_porphyrin_level1.22336546
68MP0004381_abnormal_hair_follicle1.20163794
69MP0005000_abnormal_immune_tolerance1.18729075
70MP0000689_abnormal_spleen_morphology1.16985285
71MP0002160_abnormal_reproductive_system1.16698466
72MP0002420_abnormal_adaptive_immunity1.16055232
73MP0003186_abnormal_redox_activity1.15858163
74MP0003121_genomic_imprinting1.14027338
75MP0003436_decreased_susceptibility_to1.13906842
76MP0001819_abnormal_immune_cell1.13577605
77MP0002019_abnormal_tumor_incidence1.13346047
78MP0008877_abnormal_DNA_methylation1.13105163
79MP0006072_abnormal_retinal_apoptosis1.12976084
80MP0002722_abnormal_immune_system1.11864954
81MP0006036_abnormal_mitochondrial_physio1.11501154
82MP0001727_abnormal_embryo_implantation1.10763208
83MP0010234_abnormal_vibrissa_follicle1.09393547
84MP0000716_abnormal_immune_system1.07780508
85MP0005501_abnormal_skin_physiology1.07129109
86MP0005187_abnormal_penis_morphology1.06887205
87MP0002419_abnormal_innate_immunity1.06623834
88MP0002723_abnormal_immune_serum1.06265935
89MP0000465_gastrointestinal_hemorrhage1.06138801
90MP0000647_abnormal_sebaceous_gland1.05310641
91MP0004197_abnormal_fetal_growth/weight/1.05168077
92MP0002429_abnormal_blood_cell1.03480727
93MP0000313_abnormal_cell_death1.02020328
94MP0003122_maternal_imprinting1.00498755
95MP0001661_extended_life_span1.00340253
96MP0002075_abnormal_coat/hair_pigmentati0.99432954
97MP0002452_abnormal_antigen_presenting0.99111192
98MP0001800_abnormal_humoral_immune0.98752589
99MP0002210_abnormal_sex_determination0.96790169
100MP0004233_abnormal_muscle_weight0.96426023
101MP0010030_abnormal_orbit_morphology0.96012718
102MP0002877_abnormal_melanocyte_morpholog0.96009005
103MP0001186_pigmentation_phenotype0.95152864
104MP0004133_heterotaxia0.94915293
105MP0000703_abnormal_thymus_morphology0.93534406
106MP0002086_abnormal_extraembryonic_tissu0.93025519
107MP0000858_altered_metastatic_potential0.92853235
108MP0001919_abnormal_reproductive_system0.92316661
109MP0001299_abnormal_eye_distance/0.91616042
110MP0003315_abnormal_perineum_morphology0.91144607
111MP0009697_abnormal_copulation0.90965690
112MP0002102_abnormal_ear_morphology0.90522687
113MP0000762_abnormal_tongue_morphology0.89791668
114MP0004808_abnormal_hematopoietic_stem0.88717278
115MP0000049_abnormal_middle_ear0.88603719
116MP0005389_reproductive_system_phenotype0.88552221
117MP0008995_early_reproductive_senescence0.88203723
118MP0010307_abnormal_tumor_latency0.86949273
119MP0002177_abnormal_outer_ear0.86857579
120MP0005360_urolithiasis0.86686271
121MP0004215_abnormal_myocardial_fiber0.85786588
122MP0003221_abnormal_cardiomyocyte_apopto0.85306513
123MP0000371_diluted_coat_color0.85069919
124MP0002277_abnormal_respiratory_mucosa0.84142782
125MP0003755_abnormal_palate_morphology0.83894034
126MP0006035_abnormal_mitochondrial_morpho0.83055111
127MP0002938_white_spotting0.82930777
128MP0000358_abnormal_cell_content/0.82914402
129MP0001764_abnormal_homeostasis0.82772952
130MP0000428_abnormal_craniofacial_morphol0.82372790
131MP0005332_abnormal_amino_acid0.81510421
132MP0001881_abnormal_mammary_gland0.80742277
133MP0002092_abnormal_eye_morphology0.80253213
134MP0003123_paternal_imprinting0.80214988
135MP0000613_abnormal_salivary_gland0.79914777
136MP0005395_other_phenotype0.79764193
137MP0001545_abnormal_hematopoietic_system0.79146225
138MP0005397_hematopoietic_system_phenotyp0.79146225
139MP0000685_abnormal_immune_system0.78442803
140MP0001145_abnormal_male_reproductive0.77584124
141MP0003119_abnormal_digestive_system0.77339727
142MP0003950_abnormal_plasma_membrane0.76858456
143MP0002111_abnormal_tail_morphology0.76588914
144MP0002837_dystrophic_cardiac_calcinosis0.76175378
145MP0002269_muscular_atrophy0.75749581
146MP0000537_abnormal_urethra_morphology0.75373518
147MP0003385_abnormal_body_wall0.75064239
148MP0009703_decreased_birth_body0.74643777
149MP0003879_abnormal_hair_cell0.74624638
150MP0000350_abnormal_cell_proliferation0.74454627
151MP0003195_calcinosis0.73948520
152MP0003866_abnormal_defecation0.73918717
153MP0005391_vision/eye_phenotype0.73042343
154MP0002163_abnormal_gland_morphology0.72509790
155MP0003935_abnormal_craniofacial_develop0.70871591
156MP0005085_abnormal_gallbladder_physiolo0.70754642
157MP0001929_abnormal_gametogenesis0.70273933
158MP0000627_abnormal_mammary_gland0.69855778
159MP0003880_abnormal_central_pattern0.69380248
160MP0002405_respiratory_system_inflammati0.68793700
161MP0000631_abnormal_neuroendocrine_gland0.68194807
162MP0000653_abnormal_sex_gland0.68129297
163MP0008789_abnormal_olfactory_epithelium0.68036718
164MP0004272_abnormal_basement_membrane0.67837246
165MP0002796_impaired_skin_barrier0.67381151
166MP0001915_intracranial_hemorrhage0.66253115

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)6.36383617
2Reduced antithrombin III activity (HP:0001976)6.12663440
3Abnormal glycosylation (HP:0012345)4.41198047
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.41198047
5Abnormal protein N-linked glycosylation (HP:0012347)4.41198047
6Abnormal protein glycosylation (HP:0012346)4.41198047
7Abnormal number of erythroid precursors (HP:0012131)4.11230078
8Abnormality of cells of the erythroid lineage (HP:0012130)3.98226353
9Reticulocytopenia (HP:0001896)3.93915970
10Aplastic anemia (HP:0001915)3.63188893
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.59968900
12Increased hepatocellular lipid droplets (HP:0006565)3.45195163
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.41484912
14Hepatocellular necrosis (HP:0001404)3.39038522
15Increased serum pyruvate (HP:0003542)3.29893061
16Birth length less than 3rd percentile (HP:0003561)3.17253123
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15225534
18Exertional dyspnea (HP:0002875)3.13061315
19Abnormality of glycolysis (HP:0004366)3.12748824
20Hepatic necrosis (HP:0002605)3.04978852
21Chromsome breakage (HP:0040012)3.04177368
22Severe visual impairment (HP:0001141)3.00121742
23Lipid accumulation in hepatocytes (HP:0006561)2.93122376
24Progressive macrocephaly (HP:0004481)2.92147954
25Renal Fanconi syndrome (HP:0001994)2.92056649
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91682201
27Hypobetalipoproteinemia (HP:0003563)2.88077076
28Mitochondrial inheritance (HP:0001427)2.86600222
29Hypothermia (HP:0002045)2.80797848
30Thyroid-stimulating hormone excess (HP:0002925)2.79699107
31Microvesicular hepatic steatosis (HP:0001414)2.79429859
32Cerebral edema (HP:0002181)2.77710591
33Hypoglycemic coma (HP:0001325)2.76169928
34Abnormality of the preputium (HP:0100587)2.72550823
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66753166
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66753166
37Increased CSF lactate (HP:0002490)2.66205827
38Macrocytic anemia (HP:0001972)2.60921519
39Oral leukoplakia (HP:0002745)2.58560566
40IgM deficiency (HP:0002850)2.58250018
41Abnormality of methionine metabolism (HP:0010901)2.54609529
42Thrombocytosis (HP:0001894)2.54103592
43Increased serum lactate (HP:0002151)2.53999688
44Pallor (HP:0000980)2.53236272
453-Methylglutaconic aciduria (HP:0003535)2.50810110
46Meckel diverticulum (HP:0002245)2.48913113
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48386570
48Increased intramyocellular lipid droplets (HP:0012240)2.47874757
49Multiple enchondromatosis (HP:0005701)2.46263554
50Acute necrotizing encephalopathy (HP:0006965)2.45770416
51Type 2 muscle fiber atrophy (HP:0003554)2.42802717
52Abnormality of chromosome stability (HP:0003220)2.36654959
53Abnormality of the ileum (HP:0001549)2.35653058
54Abnormality of DNA repair (HP:0003254)2.35172926
55Rough bone trabeculation (HP:0100670)2.33201801
56Hypoplastic pelvis (HP:0008839)2.32895686
57Nephroblastoma (Wilms tumor) (HP:0002667)2.32598079
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.32205839
59Pancytopenia (HP:0001876)2.30002622
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29817735
61Abnormality of alanine metabolism (HP:0010916)2.29817735
62Hyperalaninemia (HP:0003348)2.29817735
63Muscle fiber atrophy (HP:0100295)2.28976965
64Abnormal mitochondria in muscle tissue (HP:0008316)2.28116847
65True hermaphroditism (HP:0010459)2.27857108
66Premature graying of hair (HP:0002216)2.26310488
67Abnormal lung lobation (HP:0002101)2.23999400
68Bone marrow hypocellularity (HP:0005528)2.22902024
69Respiratory difficulties (HP:0002880)2.22191995
70Chronic obstructive pulmonary disease (HP:0006510)2.21223974
71Obstructive lung disease (HP:0006536)2.21223974
72Embryonal renal neoplasm (HP:0011794)2.21063346
73Petechiae (HP:0000967)2.20939376
74Elevated erythrocyte sedimentation rate (HP:0003565)2.16599864
75Exercise intolerance (HP:0003546)2.14259774
76Abnormality of the renal collecting system (HP:0004742)2.13528492
77Pancreatic fibrosis (HP:0100732)2.12866584
78Breast hypoplasia (HP:0003187)2.11785415
79Pancreatic cysts (HP:0001737)2.11574422
80Pulmonary fibrosis (HP:0002206)2.09770423
81Abnormality of serum amino acid levels (HP:0003112)2.08801989
82Abnormality of the labia minora (HP:0012880)2.07865929
83Abnormal rod and cone electroretinograms (HP:0008323)2.06936081
84Hyperglycinemia (HP:0002154)2.06622889
85Abnormality of the prostate (HP:0008775)2.04643206
86Leukodystrophy (HP:0002415)2.03519602
87Degeneration of anterior horn cells (HP:0002398)2.01865286
88Abnormality of the anterior horn cell (HP:0006802)2.01865286
89Rhabdomyosarcoma (HP:0002859)2.01167156
90Colon cancer (HP:0003003)2.00937492
91Microretrognathia (HP:0000308)2.00603638
92Duplicated collecting system (HP:0000081)2.00297624
93Attenuation of retinal blood vessels (HP:0007843)1.99331489
94Clubbing of toes (HP:0100760)1.97300087
95Myelodysplasia (HP:0002863)1.96119139
96Facial cleft (HP:0002006)1.95558624
97Increased muscle lipid content (HP:0009058)1.95170496
98Hypoglycemic seizures (HP:0002173)1.91539819
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91384490
100Granulocytopenia (HP:0001913)1.91310393
101Exercise-induced muscle cramps (HP:0003710)1.90490791
102Abnormality of the columella (HP:0009929)1.89920476
103Abnormal sex determination (HP:0012244)1.89583960
104Sex reversal (HP:0012245)1.89583960
105Abnormal spermatogenesis (HP:0008669)1.89391724
106Postnatal microcephaly (HP:0005484)1.89271400
107Absent thumb (HP:0009777)1.88040137
108Respiratory failure (HP:0002878)1.87912804
109Hyperinsulinemic hypoglycemia (HP:0000825)1.87479602
110Abnormality of renal resorption (HP:0011038)1.87478629
111Cortical visual impairment (HP:0100704)1.87332112
112Lymphoma (HP:0002665)1.87106637
113Ependymoma (HP:0002888)1.85691819
11411 pairs of ribs (HP:0000878)1.85305634
115Lactic acidosis (HP:0003128)1.85228800
116Poor head control (HP:0002421)1.84844896
117Agnosia (HP:0010524)1.84434111
118Neoplasm of the adrenal gland (HP:0100631)1.84316443
119Pancreatic islet-cell hyperplasia (HP:0004510)1.84067963
120Abnormality of T cell physiology (HP:0011840)1.83809969
121Split foot (HP:0001839)1.83405763
122Megaloblastic anemia (HP:0001889)1.82022200
123Small intestinal stenosis (HP:0012848)1.81323364
124Duodenal stenosis (HP:0100867)1.81323364
125Poikiloderma (HP:0001029)1.80990334
126Progressive muscle weakness (HP:0003323)1.80222326
127Meningitis (HP:0001287)1.79978418
128Thoracic kyphosis (HP:0002942)1.78588421
129Bifid tongue (HP:0010297)1.78115911
130Cerebral hypomyelination (HP:0006808)1.77989126
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76436997
132Abnormality of the duodenum (HP:0002246)1.75161854
133Overlapping toe (HP:0001845)1.74864982
134Lethargy (HP:0001254)1.74129783
135Methylmalonic acidemia (HP:0002912)1.72734754
136Medulloblastoma (HP:0002885)1.71193694
137Triphalangeal thumb (HP:0001199)1.71136811
138Acute encephalopathy (HP:0006846)1.70396577
139Abnormal trabecular bone morphology (HP:0100671)1.69314832
140Nemaline bodies (HP:0003798)1.69032700
141Abnormality of urine glucose concentration (HP:0011016)1.68776128
142Glycosuria (HP:0003076)1.68776128
143Patellar aplasia (HP:0006443)1.68487962
144Microcytic anemia (HP:0001935)1.67943131
145Neoplasm of the colon (HP:0100273)1.67810249
146CNS demyelination (HP:0007305)1.67787942
147Glioma (HP:0009733)1.67580346
148Proximal tubulopathy (HP:0000114)1.65381524
149Secondary amenorrhea (HP:0000869)1.62959139
150Generalized aminoaciduria (HP:0002909)1.62901984
151Abnormality of glycine metabolism (HP:0010895)1.62809462
152Abnormality of serine family amino acid metabolism (HP:0010894)1.62809462
153Abnormality of the intrinsic pathway (HP:0010989)1.62341085
154Microglossia (HP:0000171)1.62061707
155Absent radius (HP:0003974)1.58864273
156Symptomatic seizures (HP:0011145)1.56547777
157Sparse eyelashes (HP:0000653)1.56405921
158Sloping forehead (HP:0000340)1.53766344
159Increased nuchal translucency (HP:0010880)1.53648502
160Horseshoe kidney (HP:0000085)1.52226361
161Hypoplasia of the pons (HP:0012110)1.50799531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.20250233
2EIF2AK35.25566065
3STK164.75683403
4PBK3.36421090
5WEE12.70778657
6BUB12.69584885
7MST42.49116640
8MKNK22.44585427
9NLK2.39275461
10IRAK42.36120528
11IRAK32.34686693
12NME22.30189627
13ZAK2.23240638
14SRPK12.09888658
15EIF2AK21.95040432
16TLK11.94735663
17VRK21.90815893
18MKNK11.86942014
19VRK11.85627181
20PLK41.83760723
21EIF2AK11.75509821
22CAMKK21.67494079
23TRIM281.60700486
24LATS11.57531152
25CDC71.57300620
26PDK21.56302357
27BCR1.49170416
28PIM21.48072117
29MUSK1.45249598
30TEC1.43969813
31NUAK11.35562817
32TAOK21.33381621
33TAF11.26625205
34FES1.17492050
35ERBB31.13654408
36STK31.10353072
37MAP2K71.08145286
38WNK31.03900106
39DYRK31.03094628
40PLK11.02426122
41ATR1.00660370
42PRPF4B1.00310941
43CDK71.00054041
44BRSK20.99909215
45ACVR1B0.98967160
46BLK0.96677482
47BTK0.94971464
48TTK0.94375867
49STK38L0.93518080
50MAP3K120.93452096
51TXK0.93218475
52ERBB40.92556110
53CCNB10.92454337
54IRAK20.91462110
55MST1R0.90961654
56TSSK60.90830865
57KIT0.90679685
58YES10.86973851
59MAP4K20.85653654
60SCYL20.82203149
61CSNK1G10.81602674
62PAK40.81214810
63OBSCN0.81126262
64FLT30.78085699
65LATS20.78075636
66STK40.77995515
67CDK80.77166063
68STK390.76947113
69BRAF0.75766769
70PASK0.75351924
71IRAK10.75172388
72NEK20.75048797
73TESK20.74805933
74ADRBK20.73166091
75AURKB0.73059060
76CDK190.72381913
77CASK0.72095481
78FGFR10.72021500
79KDR0.71926817
80AURKA0.70444539
81NTRK30.69937275
82CSNK1G30.69027208
83NME10.68145387
84CSNK1E0.65672866
85MAP4K10.65340937
86TNK20.64352992
87CHEK20.63433181
88ZAP700.58850070
89ALK0.58053349
90MAP3K110.57406776
91MAP2K30.56461863
92PLK20.56408414
93LYN0.55543463
94AKT20.55341296
95MET0.54795280
96PLK30.54735896
97RPS6KB20.54676351
98CSNK2A10.51816081
99CAMK10.51269339
100CSNK1A1L0.51136606
101CDK10.50750505
102IKBKB0.49895225
103SYK0.49479283
104NEK10.48560390
105PNCK0.47869337
106CLK10.47512994
107TGFBR10.47080575
108CSNK1G20.46428072
109TESK10.46220449
110CDK60.46151140
111CSNK2A20.45421843
112MAP3K40.45384242
113RPS6KA40.44983806
114WNK40.43608771
115MAP3K140.43023651
116CDK20.42693815
117LIMK10.42655514
118PRKCI0.42336226
119MAP2K60.40645944
120BRSK10.38014263
121IKBKE0.35373739
122RPS6KA50.35279815
123PINK10.34891184
124CDK40.34824528
125EPHA20.34013730
126BCKDK0.33928867
127PRKDC0.33827362
128OXSR10.32587222
129PIM10.32105364
130DYRK20.30397460
131MAPK130.30330152
132DAPK10.29903882
133PHKG10.28230787
134PHKG20.28230787
135BMPR1B0.28082887
136PAK10.28006883
137BRD40.27645582
138MAPKAPK50.27169752
139CHEK10.26949998
140ATM0.26804522
141CAMK2D0.26081172
142LCK0.25113865
143CDK30.24685906
144CSF1R0.24169298
145CSNK1A10.23739897
146MAP3K80.22771271
147MAPK40.22754583
148ABL20.22389522

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94320100
2* Ribosome_Homo sapiens_hsa030104.03338050
3Mismatch repair_Homo sapiens_hsa034303.77502340
4Proteasome_Homo sapiens_hsa030503.54941005
5RNA polymerase_Homo sapiens_hsa030203.37442615
6Homologous recombination_Homo sapiens_hsa034403.18356135
7Base excision repair_Homo sapiens_hsa034102.89235272
8Pyrimidine metabolism_Homo sapiens_hsa002402.77616709
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73846992
10Nucleotide excision repair_Homo sapiens_hsa034202.71372976
11Spliceosome_Homo sapiens_hsa030402.65473187
12Fanconi anemia pathway_Homo sapiens_hsa034602.43259031
13Protein export_Homo sapiens_hsa030602.41406844
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.34458039
15Non-homologous end-joining_Homo sapiens_hsa034502.07091502
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02787904
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97034808
18RNA transport_Homo sapiens_hsa030131.89955314
19Basal transcription factors_Homo sapiens_hsa030221.88499652
20Propanoate metabolism_Homo sapiens_hsa006401.85551114
21One carbon pool by folate_Homo sapiens_hsa006701.84208401
22Pyruvate metabolism_Homo sapiens_hsa006201.69552300
23Purine metabolism_Homo sapiens_hsa002301.67991385
24Oxidative phosphorylation_Homo sapiens_hsa001901.64314443
25N-Glycan biosynthesis_Homo sapiens_hsa005101.64042589
26RNA degradation_Homo sapiens_hsa030181.63050672
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62301584
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60344838
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60184984
30Steroid biosynthesis_Homo sapiens_hsa001001.57643128
31Cell cycle_Homo sapiens_hsa041101.53094262
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50301987
33Vitamin B6 metabolism_Homo sapiens_hsa007501.47384559
34Fatty acid elongation_Homo sapiens_hsa000621.41169437
35Parkinsons disease_Homo sapiens_hsa050121.40545132
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39005459
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36265142
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35929758
39Biosynthesis of amino acids_Homo sapiens_hsa012301.34712727
40Carbon metabolism_Homo sapiens_hsa012001.33781930
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26720307
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22859264
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20290852
44Huntingtons disease_Homo sapiens_hsa050161.19628024
45Other glycan degradation_Homo sapiens_hsa005111.12453411
46p53 signaling pathway_Homo sapiens_hsa041151.11098526
47Primary immunodeficiency_Homo sapiens_hsa053401.07800809
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07798030
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05582978
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00045365
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99625603
52Sulfur metabolism_Homo sapiens_hsa009200.96162347
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96127223
54Butanoate metabolism_Homo sapiens_hsa006500.94213182
55Thyroid cancer_Homo sapiens_hsa052160.91923082
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90486408
57Fatty acid metabolism_Homo sapiens_hsa012120.90354520
58Folate biosynthesis_Homo sapiens_hsa007900.88662287
59Epstein-Barr virus infection_Homo sapiens_hsa051690.88413877
60Herpes simplex infection_Homo sapiens_hsa051680.87795535
61Fatty acid degradation_Homo sapiens_hsa000710.87711877
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87216005
63Alzheimers disease_Homo sapiens_hsa050100.84777647
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83299935
65Pentose phosphate pathway_Homo sapiens_hsa000300.82614826
66Arginine and proline metabolism_Homo sapiens_hsa003300.82163440
67Systemic lupus erythematosus_Homo sapiens_hsa053220.81876250
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78477449
69Oocyte meiosis_Homo sapiens_hsa041140.77886987
70Arginine biosynthesis_Homo sapiens_hsa002200.77374042
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76812486
72Regulation of autophagy_Homo sapiens_hsa041400.75893093
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.73210729
74Peroxisome_Homo sapiens_hsa041460.72070777
75mRNA surveillance pathway_Homo sapiens_hsa030150.70360567
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68046410
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.67025485
78Arachidonic acid metabolism_Homo sapiens_hsa005900.64270521
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64174944
80Lysine degradation_Homo sapiens_hsa003100.61832315
81Measles_Homo sapiens_hsa051620.61409696
82beta-Alanine metabolism_Homo sapiens_hsa004100.60293008
83Asthma_Homo sapiens_hsa053100.59985703
84Tryptophan metabolism_Homo sapiens_hsa003800.56281386
85Antigen processing and presentation_Homo sapiens_hsa046120.55531563
86Sulfur relay system_Homo sapiens_hsa041220.55528509
87Glutathione metabolism_Homo sapiens_hsa004800.53763800
88Metabolic pathways_Homo sapiens_hsa011000.52820954
89Allograft rejection_Homo sapiens_hsa053300.52483359
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51614770
91Hematopoietic cell lineage_Homo sapiens_hsa046400.51614733
92Renin-angiotensin system_Homo sapiens_hsa046140.51575070
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51473153
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.50840280
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.49894579
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.45825390
97Leishmaniasis_Homo sapiens_hsa051400.44652164
98Galactose metabolism_Homo sapiens_hsa000520.44225039
99Sphingolipid metabolism_Homo sapiens_hsa006000.43647875
100Hippo signaling pathway_Homo sapiens_hsa043900.42276842
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41731310
102Phenylalanine metabolism_Homo sapiens_hsa003600.41719618
103Starch and sucrose metabolism_Homo sapiens_hsa005000.41171777
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40390318
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39812335
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39672149
107Tyrosine metabolism_Homo sapiens_hsa003500.38800498
108Legionellosis_Homo sapiens_hsa051340.37663105
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37368805
110Retinol metabolism_Homo sapiens_hsa008300.36884014
111TGF-beta signaling pathway_Homo sapiens_hsa043500.34731569
112Circadian rhythm_Homo sapiens_hsa047100.33795301
113Adherens junction_Homo sapiens_hsa045200.33588686
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33434718
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.32543368
116Acute myeloid leukemia_Homo sapiens_hsa052210.32268717
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29976168
118Phototransduction_Homo sapiens_hsa047440.29890664
119Graft-versus-host disease_Homo sapiens_hsa053320.29521035
120Fat digestion and absorption_Homo sapiens_hsa049750.28839237
121Alcoholism_Homo sapiens_hsa050340.28511675
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.27526827
123Fructose and mannose metabolism_Homo sapiens_hsa000510.27484083
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27299794
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27192544
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27177725
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.27134316
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26677453
129HTLV-I infection_Homo sapiens_hsa051660.26053349
130Viral carcinogenesis_Homo sapiens_hsa052030.26032240
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24819881
132Nitrogen metabolism_Homo sapiens_hsa009100.24651301
133Apoptosis_Homo sapiens_hsa042100.24432608
134Tight junction_Homo sapiens_hsa045300.24222478
135Autoimmune thyroid disease_Homo sapiens_hsa053200.23899180
136Caffeine metabolism_Homo sapiens_hsa002320.22921416
137Type I diabetes mellitus_Homo sapiens_hsa049400.22860181
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20287198
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19856315
140Influenza A_Homo sapiens_hsa051640.19423218
141Basal cell carcinoma_Homo sapiens_hsa052170.17632630
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17113650
143Hepatitis B_Homo sapiens_hsa051610.16793757
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.15660640
145Shigellosis_Homo sapiens_hsa051310.15588418
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15158621
147Cardiac muscle contraction_Homo sapiens_hsa042600.15016302
148Selenocompound metabolism_Homo sapiens_hsa004500.14841605
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.14670793

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