MRPL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.44275889
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.58832972
3ATP synthesis coupled proton transport (GO:0015986)5.58832972
4proteasome assembly (GO:0043248)5.50896372
5purine nucleobase biosynthetic process (GO:0009113)5.20442426
6DNA deamination (GO:0045006)5.18135557
7chaperone-mediated protein transport (GO:0072321)5.17064693
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.13307901
9nucleobase biosynthetic process (GO:0046112)4.85918456
10respiratory electron transport chain (GO:0022904)4.68832094
11protein complex biogenesis (GO:0070271)4.64768288
12ribosomal small subunit assembly (GO:0000028)4.62694041
13electron transport chain (GO:0022900)4.58876160
14ribosome assembly (GO:0042255)4.54456144
15formation of translation preinitiation complex (GO:0001731)4.53952588
16mitochondrial respiratory chain complex assembly (GO:0033108)4.49223489
17maturation of SSU-rRNA (GO:0030490)4.48260267
18ribosome biogenesis (GO:0042254)4.44785375
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.41923547
20ribosomal large subunit biogenesis (GO:0042273)4.35414527
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34182555
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.34182555
23NADH dehydrogenase complex assembly (GO:0010257)4.34182555
24termination of RNA polymerase III transcription (GO:0006386)4.32916174
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.32916174
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.30901839
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.25619417
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24456467
29ribonucleoprotein complex biogenesis (GO:0022613)4.21545778
30protein neddylation (GO:0045116)4.20945692
31rRNA modification (GO:0000154)4.19771450
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.07046711
33negative regulation of ligase activity (GO:0051352)3.98253569
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.98253569
35respiratory chain complex IV assembly (GO:0008535)3.95693812
36mitotic metaphase plate congression (GO:0007080)3.95376358
377-methylguanosine mRNA capping (GO:0006370)3.92376095
38DNA replication checkpoint (GO:0000076)3.88419950
39regulation of cellular amino acid metabolic process (GO:0006521)3.88035699
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.83418846
417-methylguanosine RNA capping (GO:0009452)3.83302860
42RNA capping (GO:0036260)3.83302860
43spliceosomal snRNP assembly (GO:0000387)3.81362853
44DNA strand elongation involved in DNA replication (GO:0006271)3.77984312
45telomere maintenance via semi-conservative replication (GO:0032201)3.77107166
46rRNA processing (GO:0006364)3.76643631
47viral mRNA export from host cell nucleus (GO:0046784)3.75639866
48folic acid metabolic process (GO:0046655)3.75050998
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74488610
50cytochrome complex assembly (GO:0017004)3.73966234
51histone exchange (GO:0043486)3.72673708
52pseudouridine synthesis (GO:0001522)3.72590374
53ribosomal small subunit biogenesis (GO:0042274)3.72564203
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70303803
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70303803
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70303803
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68371899
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68371899
59DNA replication initiation (GO:0006270)3.67792663
60termination of RNA polymerase I transcription (GO:0006363)3.65962499
61positive regulation of ligase activity (GO:0051351)3.65046128
62DNA strand elongation (GO:0022616)3.64823332
63rRNA metabolic process (GO:0016072)3.64284330
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64250982
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.64250982
66transcription from RNA polymerase I promoter (GO:0006360)3.61560850
67regulation of mitochondrial translation (GO:0070129)3.60812614
68transcription elongation from RNA polymerase I promoter (GO:0006362)3.59519736
69CENP-A containing nucleosome assembly (GO:0034080)3.58941473
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.58535704
71viral transcription (GO:0019083)3.57719198
72translational termination (GO:0006415)3.57516660
73translational initiation (GO:0006413)3.55307750
74cellular component biogenesis (GO:0044085)3.53268662
75establishment of integrated proviral latency (GO:0075713)3.49204866
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48670845
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48670845
78telomere maintenance via recombination (GO:0000722)3.46090910
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44012214
80chromatin remodeling at centromere (GO:0031055)3.43543846
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42679544
82L-methionine salvage (GO:0071267)3.41441549
83L-methionine biosynthetic process (GO:0071265)3.41441549
84amino acid salvage (GO:0043102)3.41441549
85* translation (GO:0006412)3.41088918
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.40145428
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38954543
88cullin deneddylation (GO:0010388)3.38682153
89transcription-coupled nucleotide-excision repair (GO:0006283)3.38400140
90translational elongation (GO:0006414)3.36361772
91regulation of ubiquitin-protein transferase activity (GO:0051438)3.36157878
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35334029
93G1/S transition of mitotic cell cycle (GO:0000082)3.31426293
94cell cycle G1/S phase transition (GO:0044843)3.31426293
95maturation of 5.8S rRNA (GO:0000460)3.30996080
96protein deneddylation (GO:0000338)3.30045621
97protein localization to mitochondrion (GO:0070585)3.27242118
98metaphase plate congression (GO:0051310)3.25871588
99oxidative phosphorylation (GO:0006119)3.24785971
100guanosine-containing compound biosynthetic process (GO:1901070)3.24366887
101regulation of ligase activity (GO:0051340)3.22787691
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21127914
103ATP biosynthetic process (GO:0006754)3.18210588
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18149366
105water-soluble vitamin biosynthetic process (GO:0042364)3.16476342
106IMP biosynthetic process (GO:0006188)3.16255040
107transcription initiation from RNA polymerase I promoter (GO:0006361)3.15985405
108DNA double-strand break processing (GO:0000729)3.15595426
109protein targeting to mitochondrion (GO:0006626)3.15539989
110kinetochore assembly (GO:0051382)3.14667075
111purine nucleoside triphosphate biosynthetic process (GO:0009145)3.14057664
112kinetochore organization (GO:0051383)3.13524520
113establishment of protein localization to mitochondrion (GO:0072655)3.12356060
114mitotic recombination (GO:0006312)3.11196645
115rRNA methylation (GO:0031167)3.10873294
116cotranslational protein targeting to membrane (GO:0006613)3.10377264
117histone mRNA metabolic process (GO:0008334)3.10304809
118spliceosomal complex assembly (GO:0000245)3.09357632
119purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.08711867
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08167449
121establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08149472
122positive regulation of cell cycle arrest (GO:0071158)3.08002962
123protein targeting to ER (GO:0045047)3.07539724
124telomere maintenance via telomere lengthening (GO:0010833)3.06413669
125inner mitochondrial membrane organization (GO:0007007)3.06154226
126protein localization to endoplasmic reticulum (GO:0070972)3.04560009
127DNA damage response, detection of DNA damage (GO:0042769)3.04436882
128DNA replication-independent nucleosome assembly (GO:0006336)3.04157101
129DNA replication-independent nucleosome organization (GO:0034724)3.04157101
130transcription elongation from RNA polymerase II promoter (GO:0006368)3.03775633
131protein-cofactor linkage (GO:0018065)3.01479318
132attachment of spindle microtubules to kinetochore (GO:0008608)3.00628379
133peptidyl-histidine modification (GO:0018202)3.00616339
134hydrogen ion transmembrane transport (GO:1902600)2.99471138
135DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99448632
136DNA replication-dependent nucleosome organization (GO:0034723)2.91512864
137DNA replication-dependent nucleosome assembly (GO:0006335)2.91512864
138replication fork processing (GO:0031297)2.90780773
139establishment of viral latency (GO:0019043)2.87748703
140protein K6-linked ubiquitination (GO:0085020)2.87569724
141mitochondrial transport (GO:0006839)2.86213823
142ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84456798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50280974
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38716948
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18269762
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.80853382
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80628814
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79086382
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.67930999
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.56393301
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39972683
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20855897
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14629383
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00491957
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98920482
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94155858
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83726260
16VDR_23849224_ChIP-Seq_CD4+_Human2.62806629
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57842799
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56833760
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51658135
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47235098
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.46656663
22XRN2_22483619_ChIP-Seq_HELA_Human2.34759983
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33041761
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.25930313
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25618311
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25368863
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19152919
28GABP_19822575_ChIP-Seq_HepG2_Human2.18969146
29FOXP3_21729870_ChIP-Seq_TREG_Human2.13437831
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09376372
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07392386
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.06719805
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.00051895
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97066545
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95363081
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85862388
37TTF2_22483619_ChIP-Seq_HELA_Human1.82367695
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81696469
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79586009
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78316594
41AR_21909140_ChIP-Seq_LNCAP_Human1.78314578
42ELK1_19687146_ChIP-ChIP_HELA_Human1.78299693
43VDR_22108803_ChIP-Seq_LS180_Human1.77095328
44ZNF274_21170338_ChIP-Seq_K562_Hela1.75780515
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74470751
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73988809
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70672056
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68824562
49EWS_26573619_Chip-Seq_HEK293_Human1.65125194
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63317101
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56021314
52FUS_26573619_Chip-Seq_HEK293_Human1.47864674
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47068599
54KDM5A_27292631_Chip-Seq_BREAST_Human1.46394977
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43057516
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.42430791
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42178368
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.41217853
59CIITA_25753668_ChIP-Seq_RAJI_Human1.35323032
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35256818
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26312014
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26017183
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.24283236
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24259621
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23190194
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21794787
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20317079
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20291988
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19744121
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19366828
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19077268
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.18669195
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.15139655
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15076721
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14657944
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13453990
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13084284
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12681020
79IRF1_19129219_ChIP-ChIP_H3396_Human1.12064649
80IGF1R_20145208_ChIP-Seq_DFB_Human1.11696751
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.09786453
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07754475
83P300_19829295_ChIP-Seq_ESCs_Human1.05644780
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05554075
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05116604
86TP53_22573176_ChIP-Seq_HFKS_Human1.03786914
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98677171
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97304077
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97020316
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.96937185
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96917754
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95806149
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94991790
94TFEB_21752829_ChIP-Seq_HELA_Human0.94325284
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92259011
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92215958
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91599762
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91279520
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91199001
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90834858
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90418796
102MYC_18940864_ChIP-ChIP_HL60_Human0.90303579
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89854857
104CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89183435
105HTT_18923047_ChIP-ChIP_STHdh_Human0.87383824
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86953187
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86546224
108ZNF263_19887448_ChIP-Seq_K562_Human0.84209083
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84146815
110SPI1_23547873_ChIP-Seq_NB4_Human0.82843682
111SOX2_19829295_ChIP-Seq_ESCs_Human0.82771735
112NANOG_19829295_ChIP-Seq_ESCs_Human0.82771735
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82569834
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.82492603
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81486954
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81448522
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80264868
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80116448
119TAF15_26573619_Chip-Seq_HEK293_Human0.79620118
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.79467124
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.77899264
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77899264
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77141674
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76949447
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76893881
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76560605
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76259917
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75644440
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73544951
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72955355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.89717175
2MP0004957_abnormal_blastocyst_morpholog4.71034809
3MP0003111_abnormal_nucleus_morphology4.44340331
4MP0010094_abnormal_chromosome_stability4.01136839
5MP0003077_abnormal_cell_cycle3.82593193
6MP0008058_abnormal_DNA_repair3.36523282
7MP0008057_abnormal_DNA_replication3.24403120
8MP0003718_maternal_effect3.21605658
9MP0003786_premature_aging2.80063952
10MP0008932_abnormal_embryonic_tissue2.73919745
11MP0003890_abnormal_embryonic-extraembry2.73412484
12MP0008007_abnormal_cellular_replicative2.58351835
13MP0003806_abnormal_nucleotide_metabolis2.56119557
14MP0003123_paternal_imprinting2.34951621
15MP0003186_abnormal_redox_activity2.27924452
16MP0002102_abnormal_ear_morphology2.21009289
17MP0005394_taste/olfaction_phenotype2.15841102
18MP0005499_abnormal_olfactory_system2.15841102
19MP0008260_abnormal_autophagy2.15356769
20MP0002396_abnormal_hematopoietic_system2.13420142
21MP0001730_embryonic_growth_arrest2.11501385
22MP0003195_calcinosis2.09035673
23MP0000372_irregular_coat_pigmentation1.99497068
24MP0006072_abnormal_retinal_apoptosis1.93978368
25MP0008789_abnormal_olfactory_epithelium1.92552298
26MP0006036_abnormal_mitochondrial_physio1.90272450
27MP0001984_abnormal_olfaction1.85312365
28MP0008877_abnormal_DNA_methylation1.85268575
29MP0009333_abnormal_splenocyte_physiolog1.80862487
30MP0000350_abnormal_cell_proliferation1.79116294
31MP0006035_abnormal_mitochondrial_morpho1.73130735
32MP0002736_abnormal_nociception_after1.72700983
33MP0005084_abnormal_gallbladder_morpholo1.72394546
34MP0003315_abnormal_perineum_morphology1.62806316
35MP0002837_dystrophic_cardiac_calcinosis1.59497141
36MP0005397_hematopoietic_system_phenotyp1.48261527
37MP0001545_abnormal_hematopoietic_system1.48261527
38MP0002132_abnormal_respiratory_system1.47948619
39MP0008995_early_reproductive_senescence1.47248090
40MP0005380_embryogenesis_phenotype1.43624593
41MP0001672_abnormal_embryogenesis/_devel1.43624593
42MP0001697_abnormal_embryo_size1.42832383
43MP0002234_abnormal_pharynx_morphology1.41426920
44MP0002080_prenatal_lethality1.39847665
45MP0000313_abnormal_cell_death1.38122329
46MP0001764_abnormal_homeostasis1.37418667
47MP0009697_abnormal_copulation1.37055221
48MP0003880_abnormal_central_pattern1.36185255
49MP0000490_abnormal_crypts_of1.35059419
50MP0003119_abnormal_digestive_system1.31741757
51MP0001485_abnormal_pinna_reflex1.30720846
52MP0002160_abnormal_reproductive_system1.28366066
53MP0000358_abnormal_cell_content/1.28022093
54MP0003984_embryonic_growth_retardation1.27292249
55MP0005389_reproductive_system_phenotype1.24778307
56MP0002210_abnormal_sex_determination1.24143424
57MP0002088_abnormal_embryonic_growth/wei1.23754330
58MP0008872_abnormal_physiological_respon1.22686286
59MP0003567_abnormal_fetal_cardiomyocyte1.21557236
60MP0004142_abnormal_muscle_tone1.20958324
61MP0002019_abnormal_tumor_incidence1.20948486
62MP0003656_abnormal_erythrocyte_physiolo1.20076232
63MP0004133_heterotaxia1.19884235
64MP0003011_delayed_dark_adaptation1.18066293
65MP0002277_abnormal_respiratory_mucosa1.17857489
66MP0003646_muscle_fatigue1.16807549
67MP0005253_abnormal_eye_physiology1.15027400
68MP0001542_abnormal_bone_strength1.14651802
69MP0001145_abnormal_male_reproductive1.11563121
70MP0003221_abnormal_cardiomyocyte_apopto1.11374146
71MP0005551_abnormal_eye_electrophysiolog1.11060855
72MP0003121_genomic_imprinting1.10354110
73MP0004215_abnormal_myocardial_fiber1.08615672
74MP0001929_abnormal_gametogenesis1.05278751
75MP0001968_abnormal_touch/_nociception1.04258808
76MP0003937_abnormal_limbs/digits/tail_de1.03595994
77MP0009840_abnormal_foam_cell1.02546614
78MP0010307_abnormal_tumor_latency1.02256443
79MP0002233_abnormal_nose_morphology1.01789141
80MP0009379_abnormal_foot_pigmentation0.99309899
81MP0006054_spinal_hemorrhage0.99142255
82MP0004808_abnormal_hematopoietic_stem0.98277992
83MP0005395_other_phenotype0.98178447
84MP0004147_increased_porphyrin_level0.97998176
85MP0002638_abnormal_pupillary_reflex0.97349665
86MP0002090_abnormal_vision0.96865804
87MP0002085_abnormal_embryonic_tissue0.96779067
88MP0006292_abnormal_olfactory_placode0.96051770
89MP0001286_abnormal_eye_development0.95398003
90MP0000653_abnormal_sex_gland0.95109499
91MP0001853_heart_inflammation0.95087149
92MP0000631_abnormal_neuroendocrine_gland0.93840002
93MP0002086_abnormal_extraembryonic_tissu0.93312966
94MP0005075_abnormal_melanosome_morpholog0.92054622
95MP0008875_abnormal_xenobiotic_pharmacok0.91665579
96MP0010030_abnormal_orbit_morphology0.91432191
97MP0001119_abnormal_female_reproductive0.88065699
98MP0003137_abnormal_impulse_conducting0.88039557
99MP0000049_abnormal_middle_ear0.87921633
100MP0005266_abnormal_metabolism0.87113332
101MP0001919_abnormal_reproductive_system0.86772224
102MP0005379_endocrine/exocrine_gland_phen0.86368635
103MP0005377_hearing/vestibular/ear_phenot0.84147604
104MP0003878_abnormal_ear_physiology0.84147604
105MP0006276_abnormal_autonomic_nervous0.83016037
106MP0000689_abnormal_spleen_morphology0.82881366
107MP0005646_abnormal_pituitary_gland0.82710227
108MP0002254_reproductive_system_inflammat0.82111374
109MP0002722_abnormal_immune_system0.81943731
110MP0002751_abnormal_autonomic_nervous0.81512888
111MP0004084_abnormal_cardiac_muscle0.80002656
112MP0001905_abnormal_dopamine_level0.79687376
113MP0000516_abnormal_urinary_system0.78775524
114MP0005367_renal/urinary_system_phenotyp0.78775524
115MP0000750_abnormal_muscle_regeneration0.77687075
116MP0009046_muscle_twitch0.77440760
117MP0010352_gastrointestinal_tract_polyps0.77271619
118MP0005332_abnormal_amino_acid0.76436612
119MP0000647_abnormal_sebaceous_gland0.75984735
120MP0005645_abnormal_hypothalamus_physiol0.74774058
121MP0005391_vision/eye_phenotype0.74132374
122MP0004145_abnormal_muscle_electrophysio0.73266798
123MP0005384_cellular_phenotype0.71202980
124MP0005319_abnormal_enzyme/_coenzyme0.70818648
125MP0003787_abnormal_imprinting0.70489676
126MP0002084_abnormal_developmental_patter0.70488261
127MP0001293_anophthalmia0.70482009
128MP0003698_abnormal_male_reproductive0.70157117
129MP0002398_abnormal_bone_marrow0.69570348
130MP0005408_hypopigmentation0.69560223
131MP0005451_abnormal_body_composition0.67623065
132MP0003941_abnormal_skin_development0.66933579
133MP0004197_abnormal_fetal_growth/weight/0.66063170
134MP0004019_abnormal_vitamin_homeostasis0.65537831
135MP0001529_abnormal_vocalization0.65482973
136MP0002429_abnormal_blood_cell0.64971488
137MP0001756_abnormal_urination0.64544883
138MP0001661_extended_life_span0.64250482
139MP0001727_abnormal_embryo_implantation0.63869177
140MP0002938_white_spotting0.62880989
141MP0000703_abnormal_thymus_morphology0.61477907
142MP0009672_abnormal_birth_weight0.60874208
143MP0004782_abnormal_surfactant_physiolog0.60778144
144MP0003763_abnormal_thymus_physiology0.60016301
145MP0000598_abnormal_liver_morphology0.59049718
146MP0002163_abnormal_gland_morphology0.58566016
147MP0000858_altered_metastatic_potential0.58059489
148MP0005636_abnormal_mineral_homeostasis0.58051404
149MP0003136_yellow_coat_color0.56731143
150MP0005376_homeostasis/metabolism_phenot0.54567969
151MP0005621_abnormal_cell_physiology0.53808503
152MP0005671_abnormal_response_to0.50513778

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.15798218
2Breast hypoplasia (HP:0003187)4.48121283
3Abnormality of cells of the erythroid lineage (HP:0012130)4.46149571
4Cerebral hypomyelination (HP:0006808)4.29355967
5Abnormal number of erythroid precursors (HP:0012131)4.19579511
6Carpal bone hypoplasia (HP:0001498)3.83640837
7Rough bone trabeculation (HP:0100670)3.81866858
83-Methylglutaconic aciduria (HP:0003535)3.59655990
9Oral leukoplakia (HP:0002745)3.54746640
10Degeneration of anterior horn cells (HP:0002398)3.41138574
11Abnormality of the anterior horn cell (HP:0006802)3.41138574
12Reticulocytopenia (HP:0001896)3.24791382
13Macrocytic anemia (HP:0001972)3.22884361
14Patellar aplasia (HP:0006443)3.16246371
15Increased serum lactate (HP:0002151)3.15609134
16Hepatocellular necrosis (HP:0001404)3.15477674
17Hepatic necrosis (HP:0002605)3.14851389
18Hyperglycinemia (HP:0002154)3.10828620
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09195756
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09195756
21Multiple enchondromatosis (HP:0005701)3.07651684
22Aplasia/Hypoplasia of the patella (HP:0006498)3.06572707
23Increased CSF lactate (HP:0002490)3.00452557
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99083125
25Microretrognathia (HP:0000308)2.95978959
26Mitochondrial inheritance (HP:0001427)2.95263166
27Methylmalonic acidemia (HP:0002912)2.93698202
28Impulsivity (HP:0100710)2.90000826
29Aplastic anemia (HP:0001915)2.87820182
30Acute necrotizing encephalopathy (HP:0006965)2.84817701
31Increased hepatocellular lipid droplets (HP:0006565)2.82972862
32Abnormal trabecular bone morphology (HP:0100671)2.80674224
33Secondary amenorrhea (HP:0000869)2.75099862
34Microvesicular hepatic steatosis (HP:0001414)2.74785653
35Abnormality of alanine metabolism (HP:0010916)2.71569204
36Hyperalaninemia (HP:0003348)2.71569204
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71569204
38Premature ovarian failure (HP:0008209)2.69900238
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65647028
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62734158
41Methylmalonic aciduria (HP:0012120)2.61022997
42Progressive muscle weakness (HP:0003323)2.59403129
43Pancreatic cysts (HP:0001737)2.58816667
44Lipid accumulation in hepatocytes (HP:0006561)2.58025620
45Premature graying of hair (HP:0002216)2.58011337
46Sparse eyelashes (HP:0000653)2.57786722
47Megaloblastic anemia (HP:0001889)2.56672660
48Abnormal mitochondria in muscle tissue (HP:0008316)2.56479031
49Optic disc pallor (HP:0000543)2.54034521
50CNS demyelination (HP:0007305)2.52894003
51Leukodystrophy (HP:0002415)2.52297884
52Pancreatic fibrosis (HP:0100732)2.51440645
53Hyperglycinuria (HP:0003108)2.50427802
54Pallor (HP:0000980)2.50370480
55Lactic acidosis (HP:0003128)2.50280328
56CNS hypomyelination (HP:0003429)2.49565525
57Nausea (HP:0002018)2.44582803
58Acute encephalopathy (HP:0006846)2.43508926
59Abnormality of serum amino acid levels (HP:0003112)2.38669540
60Abnormality of glycolysis (HP:0004366)2.37998575
61Increased serum pyruvate (HP:0003542)2.37998575
62Abnormal spermatogenesis (HP:0008669)2.36251055
63Abnormality of methionine metabolism (HP:0010901)2.35035997
64Increased muscle lipid content (HP:0009058)2.34671776
65Abnormality of renal resorption (HP:0011038)2.33755790
66Abnormality of urine glucose concentration (HP:0011016)2.33036553
67Glycosuria (HP:0003076)2.33036553
68Abnormality of the umbilical cord (HP:0010881)2.32613791
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31830313
70Type I transferrin isoform profile (HP:0003642)2.29781162
71Septo-optic dysplasia (HP:0100842)2.29673548
72Absent thumb (HP:0009777)2.29241625
73Trismus (HP:0000211)2.28914647
74Abnormality of the labia minora (HP:0012880)2.27206452
75Abnormal protein N-linked glycosylation (HP:0012347)2.26438207
76Abnormal protein glycosylation (HP:0012346)2.26438207
77Abnormal glycosylation (HP:0012345)2.26438207
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26438207
79Abnormality of the preputium (HP:0100587)2.26420271
80Pancytopenia (HP:0001876)2.25964103
81Meckel diverticulum (HP:0002245)2.22955365
82Bone marrow hypocellularity (HP:0005528)2.21673030
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.19614686
84Cellular immunodeficiency (HP:0005374)2.19173209
85Respiratory difficulties (HP:0002880)2.18335519
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17867441
87Absent radius (HP:0003974)2.17280066
88Exertional dyspnea (HP:0002875)2.16020741
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.14978575
90Death in infancy (HP:0001522)2.13713840
91Ureteral duplication (HP:0000073)2.12946352
92Lethargy (HP:0001254)2.12225553
93Abnormality of midbrain morphology (HP:0002418)2.12199823
94Molar tooth sign on MRI (HP:0002419)2.12199823
95Colon cancer (HP:0003003)2.11968184
96True hermaphroditism (HP:0010459)2.11867192
97Progressive macrocephaly (HP:0004481)2.11767759
98Poor head control (HP:0002421)2.11568260
99Abnormality of the ileum (HP:0001549)2.10704368
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09550562
101Horseshoe kidney (HP:0000085)2.08796281
102Renal Fanconi syndrome (HP:0001994)2.08038002
103Medial flaring of the eyebrow (HP:0010747)2.07060288
104Respiratory failure (HP:0002878)2.04148578
105Chromsome breakage (HP:0040012)2.04129403
106Congenital, generalized hypertrichosis (HP:0004540)2.03517602
107Abnormality of glycine metabolism (HP:0010895)2.02103291
108Abnormality of serine family amino acid metabolism (HP:0010894)2.02103291
109Exercise intolerance (HP:0003546)2.02019876
110Abnormality of chromosome stability (HP:0003220)1.99322257
111Cleft eyelid (HP:0000625)1.99196449
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99156028
113Absent forearm bone (HP:0003953)1.99007473
114Aplasia involving forearm bones (HP:0009822)1.99007473
115Prolonged neonatal jaundice (HP:0006579)1.98723089
116Irregular epiphyses (HP:0010582)1.98500235
117Abnormal lung lobation (HP:0002101)1.97866850
118Hypoplastic pelvis (HP:0008839)1.97405731
119X-linked dominant inheritance (HP:0001423)1.96810641
120Cerebral edema (HP:0002181)1.96643419
121Selective tooth agenesis (HP:0001592)1.95287982
122Emotional lability (HP:0000712)1.95094671
123Type 2 muscle fiber atrophy (HP:0003554)1.92743194
124Unsteady gait (HP:0002317)1.91605159
125Neoplasm of the pancreas (HP:0002894)1.90768850
126Reduced antithrombin III activity (HP:0001976)1.90635121
127Increased intramyocellular lipid droplets (HP:0012240)1.90153603
128Patent foramen ovale (HP:0001655)1.88870931
129Generalized aminoaciduria (HP:0002909)1.86632457
130Intestinal atresia (HP:0011100)1.81797105
131Sclerocornea (HP:0000647)1.81342644
132Abnormal biliary tract physiology (HP:0012439)1.77610507
133Bile duct proliferation (HP:0001408)1.77610507
134Triphalangeal thumb (HP:0001199)1.77525999
135Hyperphosphaturia (HP:0003109)1.74911455
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72097958
137Dicarboxylic aciduria (HP:0003215)1.72097958
138Renal cortical cysts (HP:0000803)1.70116984
139Congenital primary aphakia (HP:0007707)1.69989203
140Nephronophthisis (HP:0000090)1.69260870
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.68291149
142Abnormality of vitamin B metabolism (HP:0004340)1.68071887
143Absent septum pellucidum (HP:0001331)1.67259162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.67932736
2WEE14.56223431
3EIF2AK14.10929715
4VRK23.98604620
5STK163.42775947
6NME23.37884025
7PLK43.04194882
8TSSK62.87269948
9BMPR1B2.80905173
10SRPK12.72297688
11TRIM282.69614016
12NUAK12.35309127
13EIF2AK32.33581695
14BRSK22.13854684
15WNK32.01014400
16NEK11.96054441
17VRK11.89544821
18NEK21.88120234
19MAP4K21.81317208
20PIM21.80737150
21EPHA21.79313706
22PLK11.75074072
23ZAK1.72151535
24TTK1.70886405
25CDC71.68715580
26TNIK1.66316005
27TESK21.63277956
28AKT31.59342406
29PLK31.57293800
30NME11.56999411
31BCKDK1.54183334
32ACVR1B1.51685712
33BRSK11.51596447
34DYRK31.51191441
35FRK1.49762770
36TAF11.38523116
37CCNB11.38116973
38PINK11.36536716
39IRAK31.36446259
40MKNK11.35574938
41AURKB1.34902796
42BRAF1.30862883
43ERBB41.30464418
44GRK11.27949065
45MKNK21.25570310
46AURKA1.23502944
47PDK41.13673272
48PDK31.13673272
49CDK71.11487662
50PLK21.11076365
51RPS6KA41.09335928
52INSRR1.03856890
53CHEK21.03206170
54PNCK1.02534240
55ARAF1.01896338
56TLK10.98508013
57RPS6KB20.97794249
58ERBB30.96836243
59ATR0.96552937
60EIF2AK20.96507193
61CSNK1G10.93047357
62STK38L0.92788388
63PDK20.92645148
64ADRBK20.92599366
65KDR0.90819276
66BCR0.88700843
67MAP3K80.84942295
68MAP3K110.83790858
69CSNK1G20.82367508
70CSNK2A10.80277763
71PIM10.79828327
72OXSR10.74511656
73MAP3K40.72452866
74CSNK2A20.71143221
75MAP2K70.69901412
76CDK40.68213457
77ABL20.68087024
78TESK10.67933690
79PAK40.67388564
80CDK80.66524036
81PAK10.65513631
82CHEK10.63791762
83STK390.63670846
84PRKCI0.63453819
85IRAK40.63326894
86STK40.63066994
87WNK40.58978104
88CSNK1A1L0.56961053
89DYRK20.56407755
90PASK0.55315244
91MAP2K30.53768236
92RPS6KA50.49012294
93FLT30.48873518
94CDK20.48079361
95TIE10.47657136
96MST40.44740306
97TAOK20.44542957
98PBK0.44303632
99PRKCG0.43800935
100MAP3K30.43759849
101STK240.41944086
102ADRBK10.41642892
103MYLK0.40576517
104MUSK0.39681891
105MAPKAPK50.38899966
106ATM0.38127524
107MAP2K60.37949865
108STK100.37901916
109MAPK130.37294677
110CSNK1A10.35042669
111PRKCE0.34406125
112IKBKB0.33694356
113TEC0.31928818
114CDK10.31904594
115ILK0.30131964
116CASK0.29946814
117MAP4K10.28686656
118NEK90.28231410
119LRRK20.26873757
120MINK10.26626944
121MAP3K120.26545980
122DAPK10.26459498
123PHKG10.26429704
124PHKG20.26429704
125TGFBR10.25732062
126CSNK1E0.25398360
127MAPKAPK30.24982210
128CDK190.24246483
129LIMK10.23869303
130CSNK1G30.22543881
131TXK0.20188730
132TYK20.19133680
133LATS20.18886139
134MAP3K50.17424690
135ZAP700.17299093
136MELK0.17280873
137STK30.17158215

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.84229628
2RNA polymerase_Homo sapiens_hsa030204.22870918
3* Ribosome_Homo sapiens_hsa030103.90827370
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80489100
5DNA replication_Homo sapiens_hsa030303.74050562
6Mismatch repair_Homo sapiens_hsa034303.04562905
7Pyrimidine metabolism_Homo sapiens_hsa002402.87538756
8RNA transport_Homo sapiens_hsa030132.85977520
9Spliceosome_Homo sapiens_hsa030402.82634865
10Vitamin B6 metabolism_Homo sapiens_hsa007502.60395997
11Base excision repair_Homo sapiens_hsa034102.38411043
12Homologous recombination_Homo sapiens_hsa034402.38392634
13Nucleotide excision repair_Homo sapiens_hsa034202.36092985
14Cell cycle_Homo sapiens_hsa041101.91646156
15Basal transcription factors_Homo sapiens_hsa030221.83330620
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81305309
17One carbon pool by folate_Homo sapiens_hsa006701.79409325
18Oxidative phosphorylation_Homo sapiens_hsa001901.70647228
19Purine metabolism_Homo sapiens_hsa002301.69427064
20Folate biosynthesis_Homo sapiens_hsa007901.67115605
21Parkinsons disease_Homo sapiens_hsa050121.64282216
22RNA degradation_Homo sapiens_hsa030181.63044798
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61652830
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54464371
25Fanconi anemia pathway_Homo sapiens_hsa034601.52011538
26Huntingtons disease_Homo sapiens_hsa050161.41158171
27Protein export_Homo sapiens_hsa030601.40195684
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40000325
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34933958
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33199096
31Sulfur relay system_Homo sapiens_hsa041221.29349989
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28979939
33Pentose phosphate pathway_Homo sapiens_hsa000301.26158267
34Butanoate metabolism_Homo sapiens_hsa006501.24633511
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19398120
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.18976640
37Regulation of autophagy_Homo sapiens_hsa041401.18209194
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17817059
39p53 signaling pathway_Homo sapiens_hsa041151.16383035
40Non-homologous end-joining_Homo sapiens_hsa034501.15081255
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12474676
42Epstein-Barr virus infection_Homo sapiens_hsa051691.10376644
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01413172
44Steroid biosynthesis_Homo sapiens_hsa001000.99310987
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98476398
46mRNA surveillance pathway_Homo sapiens_hsa030150.97265677
47Carbon metabolism_Homo sapiens_hsa012000.91678233
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91533629
49Glutathione metabolism_Homo sapiens_hsa004800.91113453
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87755392
51Fructose and mannose metabolism_Homo sapiens_hsa000510.85158545
52Phototransduction_Homo sapiens_hsa047440.81316276
53Collecting duct acid secretion_Homo sapiens_hsa049660.77760389
54Sulfur metabolism_Homo sapiens_hsa009200.76583405
55Tryptophan metabolism_Homo sapiens_hsa003800.76243083
56Alzheimers disease_Homo sapiens_hsa050100.74533940
57Metabolic pathways_Homo sapiens_hsa011000.68638202
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.68061340
59Selenocompound metabolism_Homo sapiens_hsa004500.66139436
60Caffeine metabolism_Homo sapiens_hsa002320.65467157
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64578904
62Fatty acid degradation_Homo sapiens_hsa000710.62771871
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61872597
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60406123
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.58955305
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58841331
67Oocyte meiosis_Homo sapiens_hsa041140.58018852
68Fatty acid metabolism_Homo sapiens_hsa012120.56365838
69Antigen processing and presentation_Homo sapiens_hsa046120.54929339
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52946029
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.52199238
72Nitrogen metabolism_Homo sapiens_hsa009100.51622846
73Vitamin digestion and absorption_Homo sapiens_hsa049770.50252987
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49813255
75Systemic lupus erythematosus_Homo sapiens_hsa053220.47841523
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47022160
77Legionellosis_Homo sapiens_hsa051340.45796824
78Herpes simplex infection_Homo sapiens_hsa051680.45558324
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43258679
80Arachidonic acid metabolism_Homo sapiens_hsa005900.42890359
81Galactose metabolism_Homo sapiens_hsa000520.41907978
82Arginine and proline metabolism_Homo sapiens_hsa003300.40255192
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39437547
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.34215094
85Peroxisome_Homo sapiens_hsa041460.33366381
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.33352722
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32937225
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31221910
89Pyruvate metabolism_Homo sapiens_hsa006200.30746634
90Olfactory transduction_Homo sapiens_hsa047400.29900869
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28668312
92Viral carcinogenesis_Homo sapiens_hsa052030.27220055
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26298756
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25290850
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24466164
96Phenylalanine metabolism_Homo sapiens_hsa003600.23837689
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22314626
98Linoleic acid metabolism_Homo sapiens_hsa005910.21909126
99Basal cell carcinoma_Homo sapiens_hsa052170.21897852
100Fat digestion and absorption_Homo sapiens_hsa049750.21706493
101beta-Alanine metabolism_Homo sapiens_hsa004100.20597743
102Retinol metabolism_Homo sapiens_hsa008300.19930545
103Cardiac muscle contraction_Homo sapiens_hsa042600.19630721
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.19294859
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18854913
106TGF-beta signaling pathway_Homo sapiens_hsa043500.17038875
107Hedgehog signaling pathway_Homo sapiens_hsa043400.16948028
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14964519
109N-Glycan biosynthesis_Homo sapiens_hsa005100.14918294
110Asthma_Homo sapiens_hsa053100.14780523
111Fatty acid elongation_Homo sapiens_hsa000620.13947707
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13847982
113Tyrosine metabolism_Homo sapiens_hsa003500.13049009
114HTLV-I infection_Homo sapiens_hsa051660.12875739
115Renin-angiotensin system_Homo sapiens_hsa046140.12294617
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12197404
117Propanoate metabolism_Homo sapiens_hsa006400.12148958
118Chemical carcinogenesis_Homo sapiens_hsa052040.09725230
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09344243
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09074223
121Allograft rejection_Homo sapiens_hsa053300.08666407
122Primary immunodeficiency_Homo sapiens_hsa053400.07351002
123Thyroid cancer_Homo sapiens_hsa052160.06271718
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05978603
125Other glycan degradation_Homo sapiens_hsa005110.04604213
126Apoptosis_Homo sapiens_hsa042100.04466809

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