MRPL23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.60370567
2ribosomal small subunit biogenesis (GO:0042274)6.54995503
3ribosomal small subunit assembly (GO:0000028)6.34637159
4translational termination (GO:0006415)6.29079272
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.07284963
6ATP synthesis coupled proton transport (GO:0015986)5.95218451
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.95218451
8lens fiber cell development (GO:0070307)5.91078637
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.77549770
10cotranslational protein targeting to membrane (GO:0006613)5.74846810
11protein targeting to ER (GO:0045047)5.67327232
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42169007
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.39941665
14protein localization to endoplasmic reticulum (GO:0070972)5.39383461
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.37582047
16translational elongation (GO:0006414)5.27001563
17maturation of SSU-rRNA (GO:0030490)5.10755802
18pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.04704004
19pyrimidine nucleoside monophosphate metabolic process (GO:0009129)5.01317699
20cellular protein complex disassembly (GO:0043624)4.93809257
21viral life cycle (GO:0019058)4.92621254
22base-excision repair, AP site formation (GO:0006285)4.89350957
23respiratory electron transport chain (GO:0022904)4.70628528
24ribosomal large subunit biogenesis (GO:0042273)4.64879850
25pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.64504699
26UMP biosynthetic process (GO:0006222)4.64504699
27pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.64504699
28UMP metabolic process (GO:0046049)4.64504699
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.63873358
30electron transport chain (GO:0022900)4.59859424
31proteasome assembly (GO:0043248)4.55154106
32translational initiation (GO:0006413)4.49879465
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.47413192
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.47413192
35NADH dehydrogenase complex assembly (GO:0010257)4.47413192
36deoxyribonucleotide catabolic process (GO:0009264)4.45184681
37pyrimidine nucleotide catabolic process (GO:0006244)4.42187935
38protein complex biogenesis (GO:0070271)4.35594458
39purine deoxyribonucleotide catabolic process (GO:0009155)4.25590973
40deoxyribose phosphate catabolic process (GO:0046386)4.25297845
41* translation (GO:0006412)4.25180837
42DNA deamination (GO:0045006)4.24419592
43chaperone-mediated protein transport (GO:0072321)4.24126834
44nucleobase biosynthetic process (GO:0046112)4.20451002
45pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.18583194
46regulation of isotype switching to IgG isotypes (GO:0048302)4.17251819
47protein complex disassembly (GO:0043241)4.14070332
48purine nucleotide salvage (GO:0032261)4.08103009
49termination of RNA polymerase III transcription (GO:0006386)4.02377483
50transcription elongation from RNA polymerase III promoter (GO:0006385)4.02377483
51protein neddylation (GO:0045116)3.98003379
52establishment of integrated proviral latency (GO:0075713)3.95100639
53mitochondrial respiratory chain complex assembly (GO:0033108)3.95031268
54macromolecular complex disassembly (GO:0032984)3.93861819
55nucleotide salvage (GO:0043173)3.93616016
56GTP biosynthetic process (GO:0006183)3.91112842
57respiratory chain complex IV assembly (GO:0008535)3.89815578
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84254246
59pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.75216517
60dopamine transport (GO:0015872)3.74069043
61ncRNA 3-end processing (GO:0043628)3.68841302
627-methylguanosine mRNA capping (GO:0006370)3.68445690
63RNA capping (GO:0036260)3.64752587
647-methylguanosine RNA capping (GO:0009452)3.64752587
65positive regulation of isotype switching (GO:0045830)3.63901422
66pyrimidine nucleotide biosynthetic process (GO:0006221)3.62238832
67protein targeting to membrane (GO:0006612)3.61079820
68pyrimidine nucleoside biosynthetic process (GO:0046134)3.60728452
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.57951773
70negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57887794
71regulation of mitochondrial translation (GO:0070129)3.57091823
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56150750
73ribonucleoprotein complex biogenesis (GO:0022613)3.54327730
74pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.50879916
75cellular component biogenesis (GO:0044085)3.49495011
76establishment of viral latency (GO:0019043)3.45458867
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.44626290
78pyrimidine nucleotide metabolic process (GO:0006220)3.44460390
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44039998
80rRNA modification (GO:0000154)3.44002840
81nuclear-transcribed mRNA catabolic process (GO:0000956)3.43915814
82cytochrome complex assembly (GO:0017004)3.39955022
83regulation of cellular amino acid metabolic process (GO:0006521)3.38593172
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37386043
85UTP biosynthetic process (GO:0006228)3.34665880
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34428243
872-deoxyribonucleotide metabolic process (GO:0009394)3.32323147
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32004792
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32004792
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32004792
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30949089
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30949089
93pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.30824523
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28921078
95negative regulation of ligase activity (GO:0051352)3.28921078
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28630276
97mRNA catabolic process (GO:0006402)3.26673388
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25498282
99nucleoside salvage (GO:0043174)3.25035682
100nucleobase-containing small molecule interconversion (GO:0015949)3.24924293
101telomere maintenance via semi-conservative replication (GO:0032201)3.23785022
102protein targeting to mitochondrion (GO:0006626)3.23482726
103platelet dense granule organization (GO:0060155)3.22293283
104CTP biosynthetic process (GO:0006241)3.21284287
105rRNA processing (GO:0006364)3.20926580
106pyrimidine-containing compound biosynthetic process (GO:0072528)3.20362530
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.18891921
108positive regulation of protein homodimerization activity (GO:0090073)3.18889943
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18272001
110signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18205716
111signal transduction involved in DNA damage checkpoint (GO:0072422)3.18205716
112UTP metabolic process (GO:0046051)3.17555193
113signal transduction involved in cell cycle checkpoint (GO:0072395)3.16001000
114cellular response to interferon-beta (GO:0035458)3.15742775
115establishment of protein localization to mitochondrion (GO:0072655)3.13100637
116leukotriene biosynthetic process (GO:0019370)3.12992497
117pyrimidine ribonucleotide metabolic process (GO:0009218)3.09402906
118deoxyribose phosphate metabolic process (GO:0019692)3.09259844
119guanosine-containing compound biosynthetic process (GO:1901070)3.07112770
120transcription elongation from RNA polymerase I promoter (GO:0006362)3.07087477
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07011113
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06468982
123formation of translation preinitiation complex (GO:0001731)3.06039300
124rRNA metabolic process (GO:0016072)3.05867755
125transcription-coupled nucleotide-excision repair (GO:0006283)3.02408115
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01757374
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01757374
128ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00924912
129GDP-mannose metabolic process (GO:0019673)2.99364459
130termination of RNA polymerase I transcription (GO:0006363)2.98801333
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98530299
132RNA catabolic process (GO:0006401)2.96950936
133GPI anchor biosynthetic process (GO:0006506)2.95943934
134pyrimidine nucleoside metabolic process (GO:0006213)2.95857686
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.95841193
136pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94811741
137positive regulation of DNA recombination (GO:0045911)2.94288252
138peptidyl-histidine modification (GO:0018202)2.94107665
139oxidative phosphorylation (GO:0006119)2.93628965
140pseudouridine synthesis (GO:0001522)2.92658540
141ATP biosynthetic process (GO:0006754)2.92414224
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91744364
143mannosylation (GO:0097502)2.91055683
144metallo-sulfur cluster assembly (GO:0031163)2.91033020
145iron-sulfur cluster assembly (GO:0016226)2.91033020
146purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90843681
147DNA strand elongation involved in DNA replication (GO:0006271)2.90356146
148spliceosomal snRNP assembly (GO:0000387)2.89711248
149rRNA methylation (GO:0031167)2.89711133
150negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.89586000
151CTP metabolic process (GO:0046036)2.89236433
152protein maturation by protein folding (GO:0022417)2.85671369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.48735551
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.74013224
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.31376969
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.20539343
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.02636455
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77871573
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70877108
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.59836921
9* MYC_18555785_ChIP-Seq_MESCs_Mouse3.56647330
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52559190
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.45945981
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42858253
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20459281
14VDR_21846776_ChIP-Seq_THP-1_Human3.11614265
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99740944
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88723303
17E2F7_22180533_ChIP-Seq_HELA_Human2.85991194
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83606239
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76706889
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72823777
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68867838
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66215780
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.52942839
24VDR_23849224_ChIP-Seq_CD4+_Human2.50080381
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.44892678
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35608464
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31120419
28* LXR_22292898_ChIP-Seq_THP-1_Human2.28616318
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22792735
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18395199
31FOXP3_21729870_ChIP-Seq_TREG_Human2.16959674
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.15683960
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11576516
34ELK1_19687146_ChIP-ChIP_HELA_Human2.09275236
35TET1_21451524_ChIP-Seq_MESCs_Mouse2.01452184
36TTF2_22483619_ChIP-Seq_HELA_Human2.01135847
37XRN2_22483619_ChIP-Seq_HELA_Human1.97115168
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91797924
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87155714
40DCP1A_22483619_ChIP-Seq_HELA_Human1.86260912
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86193287
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85654380
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84618888
44IRF1_19129219_ChIP-ChIP_H3396_Human1.82310451
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.80650883
46MYC_22102868_ChIP-Seq_BL_Human1.78367637
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76911535
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.73985652
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73496313
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.72732479
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70325183
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70095633
53ZNF263_19887448_ChIP-Seq_K562_Human1.69571371
54P68_20966046_ChIP-Seq_HELA_Human1.67806686
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.67486797
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65160191
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64349659
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60939930
59BCL6_27268052_Chip-Seq_Bcells_Human1.57737788
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52362653
61VDR_24763502_ChIP-Seq_THP-1_Human1.51156979
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50607365
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50166197
64MYC_18940864_ChIP-ChIP_HL60_Human1.50092991
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48951449
66* GABP_19822575_ChIP-Seq_HepG2_Human1.48510176
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.42595835
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.42591378
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41304316
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40694272
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40691388
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39761379
73CTCF_26484167_Chip-Seq_Bcells_Mouse1.37512072
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37221247
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34826754
76RACK7_27058665_Chip-Seq_MCF-7_Human1.31714970
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29178783
78BCOR_27268052_Chip-Seq_Bcells_Human1.29070806
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28149048
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26707700
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26429289
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24676816
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24231138
84IGF1R_20145208_ChIP-Seq_DFB_Human1.22793900
85* FOXP1_21924763_ChIP-Seq_HESCs_Human1.22408218
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21812831
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21149399
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20939696
89* MAF_26560356_Chip-Seq_TH2_Human1.20582538
90PHF8_20622854_ChIP-Seq_HELA_Human1.20185785
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20138546
92MAF_26560356_Chip-Seq_TH1_Human1.19580600
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18695426
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18665585
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.18276341
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.18229540
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17999917
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17042379
99* CTCF_21964334_Chip-Seq_Bcells_Human1.16336158
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15776888
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14459742
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14287690
103TP63_17297297_ChIP-ChIP_HaCaT_Human1.14157832
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12422734
105E2F1_20622854_ChIP-Seq_HELA_Human1.11248101
106CTCF_20526341_ChIP-Seq_ESCs_Human1.09774079
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09329457
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08894410
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08709439
110* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08635756
111UTX_26944678_Chip-Seq_JUKART_Human1.08113622
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07961786
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07355108
114* SA1_27219007_Chip-Seq_Bcells_Human1.06202974
115* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05656343
116KDM2B_26808549_Chip-Seq_DND41_Human1.03010875
117SPI1_23547873_ChIP-Seq_NB4_Human1.02218466
118CIITA_25753668_ChIP-Seq_RAJI_Human1.01116825
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01051758
120* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00857630
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00686221
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00383538
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99627966
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99565156
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98916794
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96090108
127FUS_26573619_Chip-Seq_HEK293_Human0.95031375
128IRF8_21731497_ChIP-ChIP_J774_Mouse0.93259814
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93202942
130* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92872881
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90714054
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90408195
133IRF8_22096565_ChIP-ChIP_GC-B_Human0.88844170
134VDR_22108803_ChIP-Seq_LS180_Human0.88259222
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86609350
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85316388
137MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82167945
138STAT1_20625510_ChIP-Seq_HELA_Human0.81719763
139TAF15_26573619_Chip-Seq_HEK293_Human0.78952454
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.78093165
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77760183
142* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77615657
143EWS_26573619_Chip-Seq_HEK293_Human0.76306064
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76276641
145* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74008988
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73861834
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.71255322
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70655540
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69855508
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69776982
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68509496
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.65874561
153SCL_19346495_ChIP-Seq_HPC-7_Human0.64484987
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.63758015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.98593457
2MP0006082_CNS_inflammation4.60452832
3MP0001529_abnormal_vocalization3.28748548
4MP0001188_hyperpigmentation2.95393643
5MP0000858_altered_metastatic_potential2.94265119
6MP0001905_abnormal_dopamine_level2.79853429
7MP0006292_abnormal_olfactory_placode2.73845076
8MP0001873_stomach_inflammation2.51448143
9MP0004381_abnormal_hair_follicle2.35594445
10MP0002638_abnormal_pupillary_reflex2.31410996
11MP0008058_abnormal_DNA_repair2.29995781
12MP0005409_darkened_coat_color2.27787229
13MP0003880_abnormal_central_pattern2.23210921
14MP0003136_yellow_coat_color2.21773830
15MP0002132_abnormal_respiratory_system2.17375502
16MP0001986_abnormal_taste_sensitivity2.11537594
17MP0006276_abnormal_autonomic_nervous2.06610891
18MP0005058_abnormal_lysosome_morphology2.03259895
19MP0005408_hypopigmentation2.03217532
20MP0005075_abnormal_melanosome_morpholog2.02475212
21MP0003693_abnormal_embryo_hatching2.01534895
22MP0005174_abnormal_tail_pigmentation2.00016895
23MP0000678_abnormal_parathyroid_gland1.94968037
24MP0008057_abnormal_DNA_replication1.94746973
25MP0002148_abnormal_hypersensitivity_rea1.94595950
26MP0005671_abnormal_response_to1.88379993
27MP0002163_abnormal_gland_morphology1.81941988
28MP0001835_abnormal_antigen_presentation1.78858259
29MP0002938_white_spotting1.78128388
30MP0004185_abnormal_adipocyte_glucose1.75177999
31MP0002102_abnormal_ear_morphology1.75044739
32MP0000566_synostosis1.74320680
33MP0000015_abnormal_ear_pigmentation1.73614224
34MP0000372_irregular_coat_pigmentation1.72456918
35MP0009278_abnormal_bone_marrow1.71143918
36MP0005379_endocrine/exocrine_gland_phen1.68458152
37MP0009785_altered_susceptibility_to1.65598980
38MP0002095_abnormal_skin_pigmentation1.64119675
39MP0005423_abnormal_somatic_nervous1.62719848
40MP0006036_abnormal_mitochondrial_physio1.54893113
41MP0010155_abnormal_intestine_physiology1.53753205
42MP0004957_abnormal_blastocyst_morpholog1.52984225
43MP0003186_abnormal_redox_activity1.52380862
44MP0004858_abnormal_nervous_system1.50735427
45MP0003786_premature_aging1.50690536
46MP0003763_abnormal_thymus_physiology1.49751193
47MP0009697_abnormal_copulation1.49118604
48MP0004142_abnormal_muscle_tone1.48269624
49MP0006035_abnormal_mitochondrial_morpho1.44091505
50MP0004782_abnormal_surfactant_physiolog1.44075342
51MP0008469_abnormal_protein_level1.41597491
52MP0003724_increased_susceptibility_to1.35362705
53MP0009333_abnormal_splenocyte_physiolog1.34359647
54MP0002277_abnormal_respiratory_mucosa1.33767512
55MP0005171_absent_coat_pigmentation1.32627344
56MP0005084_abnormal_gallbladder_morpholo1.31713524
57MP0008932_abnormal_embryonic_tissue1.31689475
58MP0001663_abnormal_digestive_system1.31438418
59MP0000685_abnormal_immune_system1.30559356
60MP0010094_abnormal_chromosome_stability1.29720970
61MP0001845_abnormal_inflammatory_respons1.27761309
62MP0003718_maternal_effect1.27602181
63MP0004510_myositis1.26119814
64MP0003191_abnormal_cellular_cholesterol1.24136834
65MP0005000_abnormal_immune_tolerance1.23885626
66MP0008995_early_reproductive_senescence1.20048223
67MP0005025_abnormal_response_to1.19239478
68MP0002751_abnormal_autonomic_nervous1.18563016
69MP0003077_abnormal_cell_cycle1.18513016
70MP0008260_abnormal_autophagy1.17743635
71MP0001853_heart_inflammation1.17619911
72MP0005464_abnormal_platelet_physiology1.16040968
73MP0005397_hematopoietic_system_phenotyp1.13824788
74MP0001545_abnormal_hematopoietic_system1.13824788
75MP0002723_abnormal_immune_serum1.09661359
76MP0002837_dystrophic_cardiac_calcinosis1.09549160
77MP0003303_peritoneal_inflammation1.08258281
78MP0008877_abnormal_DNA_methylation1.05863821
79MP0005330_cardiomyopathy1.05709284
80MP0008789_abnormal_olfactory_epithelium1.03615677
81MP0002139_abnormal_hepatobiliary_system1.03330468
82MP0003315_abnormal_perineum_morphology1.03304327
83MP0000343_altered_response_to1.01592460
84MP0002249_abnormal_larynx_morphology1.00562909
85MP0001800_abnormal_humoral_immune1.00326382
86MP0001727_abnormal_embryo_implantation1.00088358
87MP0005451_abnormal_body_composition0.99532132
88MP0009840_abnormal_foam_cell0.98477779
89MP0002420_abnormal_adaptive_immunity0.97923355
90MP0005381_digestive/alimentary_phenotyp0.97245322
91MP0001819_abnormal_immune_cell0.96856611
92MP0000681_abnormal_thyroid_gland0.96215079
93MP0000049_abnormal_middle_ear0.95203812
94MP0005319_abnormal_enzyme/_coenzyme0.94961751
95MP0002876_abnormal_thyroid_physiology0.92927957
96MP0009643_abnormal_urine_homeostasis0.91703884
97MP0002019_abnormal_tumor_incidence0.90796020
98MP0002452_abnormal_antigen_presenting0.90647726
99MP0000750_abnormal_muscle_regeneration0.89127938
100MP0005645_abnormal_hypothalamus_physiol0.88797142
101MP0005666_abnormal_adipose_tissue0.88703479
102MP0000313_abnormal_cell_death0.87268030
103MP0002398_abnormal_bone_marrow0.87200239
104MP0000749_muscle_degeneration0.86975371
105MP0002396_abnormal_hematopoietic_system0.86786187
106MP0008007_abnormal_cellular_replicative0.82952869
107MP0005375_adipose_tissue_phenotype0.82871171
108MP0003075_altered_response_to0.81095413
109MP0000716_abnormal_immune_system0.80991235
110MP0010386_abnormal_urinary_bladder0.78567808
111MP0000689_abnormal_spleen_morphology0.78479955
112MP0002735_abnormal_chemical_nociception0.77869798
113MP0002419_abnormal_innate_immunity0.77681763
114MP0005501_abnormal_skin_physiology0.77385103
115MP0003111_abnormal_nucleus_morphology0.76776360
116MP0000759_abnormal_skeletal_muscle0.76303120
117MP0002736_abnormal_nociception_after0.76199602
118MP0008872_abnormal_physiological_respon0.75987315
119MP0001790_abnormal_immune_system0.75972616
120MP0005387_immune_system_phenotype0.75972616
121MP0001186_pigmentation_phenotype0.75041696
122MP0002722_abnormal_immune_system0.74771436
123MP0009764_decreased_sensitivity_to0.74584338
124MP0009053_abnormal_anal_canal0.74323759
125MP0002429_abnormal_blood_cell0.74303402
126MP0005166_decreased_susceptibility_to0.73507947
127MP0004133_heterotaxia0.73167961
128MP0002405_respiratory_system_inflammati0.71936770
129MP0003436_decreased_susceptibility_to0.71749060
130MP0004147_increased_porphyrin_level0.70834012
131MP0003646_muscle_fatigue0.70739655
132MP0001661_extended_life_span0.70698645
133MP0004742_abnormal_vestibular_system0.70298391
134MP0000003_abnormal_adipose_tissue0.70171924
135MP0003011_delayed_dark_adaptation0.69877140
136MP0000703_abnormal_thymus_morphology0.68866105
137MP0003122_maternal_imprinting0.68755675
138MP0004947_skin_inflammation0.68180043
139MP0000026_abnormal_inner_ear0.67814571
140MP0003806_abnormal_nucleotide_metabolis0.67487831
141MP0003941_abnormal_skin_development0.67331763
142MP0001764_abnormal_homeostasis0.65376760
143MP0005636_abnormal_mineral_homeostasis0.65350281
144MP0006072_abnormal_retinal_apoptosis0.65226444
145MP0000490_abnormal_crypts_of0.65163799
146MP0001968_abnormal_touch/_nociception0.65010908

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.42968756
2Acute necrotizing encephalopathy (HP:0006965)5.98899116
3Abnormality of the nasal mucosa (HP:0000433)5.65565887
4Mitochondrial inheritance (HP:0001427)5.38221658
5Abnormal mitochondria in muscle tissue (HP:0008316)5.26734872
6Abnormality of cells of the erythroid lineage (HP:0012130)5.17447179
7Reticulocytopenia (HP:0001896)4.89775726
8Abnormal number of erythroid precursors (HP:0012131)4.86045945
9Progressive macrocephaly (HP:0004481)4.75073167
10Hepatocellular necrosis (HP:0001404)4.70213455
11Acute encephalopathy (HP:0006846)4.62036762
12Thrombocytosis (HP:0001894)4.55458915
13Increased CSF lactate (HP:0002490)4.50330502
14Increased hepatocellular lipid droplets (HP:0006565)4.47271916
153-Methylglutaconic aciduria (HP:0003535)4.46513987
16Renal Fanconi syndrome (HP:0001994)4.17802132
17Abnormality of pyrimidine metabolism (HP:0004353)4.14981375
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.10117752
19Hepatic necrosis (HP:0002605)4.07774263
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.99789980
21Lipid accumulation in hepatocytes (HP:0006561)3.77136042
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.66891813
23Zonular cataract (HP:0010920)3.66194820
24Pallor (HP:0000980)3.62436122
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61310795
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61310795
27Macrocytic anemia (HP:0001972)3.55122632
28Ragged-red muscle fibers (HP:0003200)3.54444764
29Exertional dyspnea (HP:0002875)3.45039572
30Elevated erythrocyte sedimentation rate (HP:0003565)3.41673029
31Exercise intolerance (HP:0003546)3.38025512
32Abnormality of the anterior horn cell (HP:0006802)3.30209612
33Degeneration of anterior horn cells (HP:0002398)3.30209612
34Increased serum lactate (HP:0002151)3.20839314
35Optic disc pallor (HP:0000543)3.10465304
36Diaphragmatic weakness (HP:0009113)3.10127165
37Stridor (HP:0010307)3.05778853
38Megaloblastic anemia (HP:0001889)3.04717204
39Increased intramyocellular lipid droplets (HP:0012240)3.02624042
40Cerebral edema (HP:0002181)3.01565612
41Lactic acidosis (HP:0003128)3.00318261
42Respiratory failure (HP:0002878)2.98734040
43Respiratory difficulties (HP:0002880)2.86825039
44Microvesicular hepatic steatosis (HP:0001414)2.86816307
45Abnormality of T cell physiology (HP:0011840)2.84255569
46Type I transferrin isoform profile (HP:0003642)2.84137815
47Testicular atrophy (HP:0000029)2.81818971
48Leukodystrophy (HP:0002415)2.76096116
49Increased serum ferritin (HP:0003281)2.65613952
50Duplicated collecting system (HP:0000081)2.57515948
51Abnormality of renal resorption (HP:0011038)2.56839974
52Abnormality of glycolysis (HP:0004366)2.56422774
53Increased serum pyruvate (HP:0003542)2.56422774
54Chronic obstructive pulmonary disease (HP:0006510)2.54430732
55Obstructive lung disease (HP:0006536)2.54430732
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51892765
57Aplastic anemia (HP:0001915)2.51023650
58Abnormality of the renal collecting system (HP:0004742)2.48996637
59Hypothermia (HP:0002045)2.48693996
60Vacuolated lymphocytes (HP:0001922)2.36916474
61Hypertensive crisis (HP:0100735)2.36784128
62Increased muscle lipid content (HP:0009058)2.33592438
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31478256
64Delayed CNS myelination (HP:0002188)2.29866895
65Interstitial pulmonary disease (HP:0006530)2.26098185
66Rhabdomyolysis (HP:0003201)2.19626691
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.16406006
68Agammaglobulinemia (HP:0004432)2.16191046
69Parakeratosis (HP:0001036)2.15301787
70Broad distal phalanx of finger (HP:0009836)2.12910849
71Abnormal pupillary function (HP:0007686)2.12111309
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11442112
7311 pairs of ribs (HP:0000878)2.09884067
74Abnormality of liposaccharide metabolism (HP:0010968)2.09778765
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.09778765
76Abnormality of glycolipid metabolism (HP:0010969)2.09778765
77Multiple enchondromatosis (HP:0005701)2.08704851
78Unilateral renal agenesis (HP:0000122)2.07793880
79Erythema (HP:0010783)2.06764930
80Progressive muscle weakness (HP:0003323)2.03172620
81Myositis (HP:0100614)2.03105532
82Gout (HP:0001997)2.02304159
83Birth length less than 3rd percentile (HP:0003561)2.02003775
84Abnormality of secondary sexual hair (HP:0009888)2.01794609
85Abnormality of the axillary hair (HP:0100134)2.01794609
86Neoplasm of head and neck (HP:0012288)2.01380720
87Esophageal neoplasm (HP:0100751)2.01380720
88Chromsome breakage (HP:0040012)2.01122333
89Microretrognathia (HP:0000308)1.99537037
90Abnormality of nucleobase metabolism (HP:0010932)1.98571891
91Purpura (HP:0000979)1.98068754
92Mediastinal lymphadenopathy (HP:0100721)1.97556899
93Recurrent bacterial skin infections (HP:0005406)1.97488801
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96109994
95Dicarboxylic aciduria (HP:0003215)1.96109994
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94982977
97IgM deficiency (HP:0002850)1.94542115
98Cerebral hypomyelination (HP:0006808)1.94257934
99J-shaped sella turcica (HP:0002680)1.93523308
100Pancreatic fibrosis (HP:0100732)1.91786314
101Patchy hypopigmentation of hair (HP:0011365)1.90345356
102Abnormality of urine glucose concentration (HP:0011016)1.89316672
103Glycosuria (HP:0003076)1.89316672
104Athetosis (HP:0002305)1.89085543
105Emotional lability (HP:0000712)1.87792046
106Pancytopenia (HP:0001876)1.87650363
107Abnormality of iron homeostasis (HP:0011031)1.86050520
108Bulbar palsy (HP:0001283)1.84737398
109Premature graying of hair (HP:0002216)1.84364039
110X-linked dominant inheritance (HP:0001423)1.84184598
111Joint stiffness (HP:0001387)1.83453048
112Abnormal respiratory motile cilium morphology (HP:0005938)1.82625150
113Abnormal respiratory epithelium morphology (HP:0012253)1.82625150
114True hermaphroditism (HP:0010459)1.82407867
115Type 2 muscle fiber atrophy (HP:0003554)1.79616865
116CNS demyelination (HP:0007305)1.78491170
117Rough bone trabeculation (HP:0100670)1.77673644
118Petechiae (HP:0000967)1.77479125
119Gastrointestinal stroma tumor (HP:0100723)1.77207879
120Asplenia (HP:0001746)1.76784231
121Blindness (HP:0000618)1.76781695
122Aplasia/hypoplasia of the uterus (HP:0008684)1.75432299
123Dysphonia (HP:0001618)1.75036158
124Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74995433
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74813881
126Abnormal protein N-linked glycosylation (HP:0012347)1.74813881
127Abnormal protein glycosylation (HP:0012346)1.74813881
128Abnormal glycosylation (HP:0012345)1.74813881
129Conical tooth (HP:0000698)1.74428936
130Medial flaring of the eyebrow (HP:0010747)1.74344368
131Abnormality of the preputium (HP:0100587)1.74049496
132Myopathic facies (HP:0002058)1.72671810
133Hyperthyroidism (HP:0000836)1.71812877
134Abnormal ciliary motility (HP:0012262)1.70376845
135Pancreatic cysts (HP:0001737)1.69808943
136Premature skin wrinkling (HP:0100678)1.69356396
137Prostate neoplasm (HP:0100787)1.69337455
138Abnormality of macrophages (HP:0004311)1.69238983
139Achilles tendon contracture (HP:0001771)1.69167694
140Absent thumb (HP:0009777)1.68783941
141Triphalangeal thumb (HP:0001199)1.68342291
142Renal tubular dysfunction (HP:0000124)1.68254048
143Vertebral compression fractures (HP:0002953)1.67599456
144Hyperphosphaturia (HP:0003109)1.66474417
145White forelock (HP:0002211)1.64689480
146Congenital ichthyosiform erythroderma (HP:0007431)1.64222250
147Congenital, generalized hypertrichosis (HP:0004540)1.64145703
148Duplication of thumb phalanx (HP:0009942)1.63766137
149Abnormality of T cells (HP:0002843)1.63222961
150Abnormal trabecular bone morphology (HP:0100671)1.61588076
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60697593
152Concave nail (HP:0001598)1.60229389
153Systemic lupus erythematosus (HP:0002725)1.59217445
154Reduced antithrombin III activity (HP:0001976)1.58861750
155Abnormality of the prostate (HP:0008775)1.58231242
156Carpal bone hypoplasia (HP:0001498)1.57697306
157Limb dystonia (HP:0002451)1.57137280
158Muscle fiber atrophy (HP:0100295)1.56765897
159Prolonged neonatal jaundice (HP:0006579)1.54819179
160Abnormal hair whorl (HP:0010721)1.53869240
161Depressed nasal ridge (HP:0000457)1.53728141
162IgG deficiency (HP:0004315)1.53069969
163Recurrent abscess formation (HP:0002722)1.50920955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.24576684
2NME23.84483918
3BUB13.44280930
4VRK22.86488948
5ARAF2.65043135
6NME12.37995359
7MAP3K122.35276911
8SMG12.35145015
9ITK2.29799374
10BMPR1B2.28586460
11SRPK12.28411575
12MST42.24767343
13VRK12.21475185
14CASK2.08073673
15TBK12.04428660
16EIF2AK31.96590406
17ADRBK21.88486325
18TNIK1.87839850
19PBK1.83644934
20IRAK31.80649877
21ERN11.79144125
22MAPKAPK51.73656689
23TRIB31.70480610
24TESK11.70107224
25ZAP701.68739377
26MUSK1.60406468
27ACVR1B1.52868528
28BLK1.51487049
29WEE11.50846444
30MYLK1.49443107
31IRAK41.49316463
32PRKG21.48935924
33MKNK11.48149522
34PLK41.47361719
35TXK1.40486474
36CDK191.39116800
37PIM21.35991520
38ZAK1.33817440
39TEC1.32853338
40LRRK21.32427362
41SCYL21.28590012
42GRK71.28306936
43CDK41.26554082
44ICK1.26149708
45CHEK21.22226824
46TSSK61.18568566
47MAP2K71.18546626
48KDR1.17055501
49EIF2AK21.16677580
50MAP2K31.15905456
51TESK21.15261369
52EIF2AK11.12398019
53PTK2B1.06691288
54RPS6KA51.06494549
55TLK11.04829993
56PIM11.02171780
57DAPK11.00749844
58BMPR21.00376932
59DYRK21.00358583
60PAK40.99403134
61YES10.95430301
62PRPF4B0.95131015
63GSK3A0.93609268
64BTK0.93253935
65IKBKB0.87230689
66MKNK20.87002318
67CDK80.84197154
68STK40.83742817
69SYK0.83653178
70NLK0.80843326
71OBSCN0.79408684
72CSNK1G30.77732335
73LYN0.76786260
74RPS6KB20.76524982
75MAPK130.76457534
76GRK10.73990470
77TTN0.73979249
78TAOK10.73971606
79KIT0.70796480
80CSNK2A10.70197654
81SIK30.69966018
82IKBKE0.69108296
83PNCK0.66870409
84TGFBR10.66840891
85CCNB10.66783757
86MAP3K140.65618995
87SIK10.65411210
88TYK20.64944427
89IRAK10.64129565
90BCKDK0.64118916
91MAP3K80.64053805
92MAP4K10.63492803
93ABL20.62255627
94BRAF0.61413094
95CSNK2A20.60558898
96MAP3K30.59864790
97MAPK70.59260534
98ATR0.59199381
99BCR0.58891691
100CAMK2B0.57043927
101CDC70.56429251
102UHMK10.56100728
103ILK0.55988920
104RIPK40.55967017
105DYRK30.55871082
106AKT20.52947277
107MAP3K130.52668402
108AURKA0.52602305
109TAOK20.52529022
110MAPK110.51238463
111PASK0.51183478
112RPS6KL10.50436792
113RPS6KC10.50436792
114LIMK10.49432294
115MOS0.49073600
116MAP3K110.48483622
117ADRBK10.48384135
118PLK10.48308491
119MAP2K20.46922900
120PAK10.46467774
121PDPK10.46363344
122MAP3K70.45862593
123CLK10.45702174
124EPHA20.45688748
125RPS6KA60.45330751
126CDK70.44978961
127AURKB0.44754789
128LCK0.44739298
129WNK30.42337552
130FES0.42100207
131GRK60.40833544
132MAPK40.40685620
133PDK20.40209504
134CSNK1A1L0.39872106
135BRSK20.39755605
136DAPK30.38632009
137MAPK150.38613152
138CSNK1G10.38499304
139PRKCD0.38458219
140CAMK2G0.38286282
141PRKCI0.37591458
142PLK30.36397748
143OXSR10.35722773
144PRKD20.35655960
145PIK3CG0.35214932
146NEK60.35157369
147CSNK1A10.35133184
148IRAK20.34239225
149EEF2K0.34132605
150PKN10.34041957
151MATK0.33664651
152RPS6KA40.32293951
153RPS6KA10.29470081

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.63965424
2Oxidative phosphorylation_Homo sapiens_hsa001904.45680277
3Proteasome_Homo sapiens_hsa030504.00501641
4Parkinsons disease_Homo sapiens_hsa050123.89284792
5RNA polymerase_Homo sapiens_hsa030203.51787388
6Protein export_Homo sapiens_hsa030603.05398205
7Huntingtons disease_Homo sapiens_hsa050162.81225017
8Alzheimers disease_Homo sapiens_hsa050102.73914230
9DNA replication_Homo sapiens_hsa030302.73752532
10Mismatch repair_Homo sapiens_hsa034302.38462607
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34576318
12Pyrimidine metabolism_Homo sapiens_hsa002402.27210395
13Homologous recombination_Homo sapiens_hsa034402.18749511
14Spliceosome_Homo sapiens_hsa030402.15549274
15Nucleotide excision repair_Homo sapiens_hsa034201.86991656
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84479651
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77242325
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74725618
19Base excision repair_Homo sapiens_hsa034101.70869443
20Non-homologous end-joining_Homo sapiens_hsa034501.57819859
21Basal transcription factors_Homo sapiens_hsa030221.40543906
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40354909
23Fanconi anemia pathway_Homo sapiens_hsa034601.39494055
24Cardiac muscle contraction_Homo sapiens_hsa042601.38496334
25Purine metabolism_Homo sapiens_hsa002301.38456970
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29741834
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29546324
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26399117
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19255634
30Galactose metabolism_Homo sapiens_hsa000521.17332151
31Fructose and mannose metabolism_Homo sapiens_hsa000511.15553666
32Staphylococcus aureus infection_Homo sapiens_hsa051501.15394755
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15283168
34RNA degradation_Homo sapiens_hsa030181.13362580
35Fatty acid elongation_Homo sapiens_hsa000621.12993959
36Biosynthesis of amino acids_Homo sapiens_hsa012301.12392693
37Vitamin B6 metabolism_Homo sapiens_hsa007501.08126724
38Viral myocarditis_Homo sapiens_hsa054161.07305177
39Primary immunodeficiency_Homo sapiens_hsa053401.06797407
40Allograft rejection_Homo sapiens_hsa053301.03865129
41RNA transport_Homo sapiens_hsa030131.00950048
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98677850
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95735579
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92055894
45Collecting duct acid secretion_Homo sapiens_hsa049660.91397586
46Arachidonic acid metabolism_Homo sapiens_hsa005900.85431065
47Arginine biosynthesis_Homo sapiens_hsa002200.85311394
48Carbon metabolism_Homo sapiens_hsa012000.85031858
49Graft-versus-host disease_Homo sapiens_hsa053320.82831986
50Leishmaniasis_Homo sapiens_hsa051400.81096382
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.80588840
52Autoimmune thyroid disease_Homo sapiens_hsa053200.77190318
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77149704
54Phototransduction_Homo sapiens_hsa047440.74175051
55Lysosome_Homo sapiens_hsa041420.73070605
56Metabolic pathways_Homo sapiens_hsa011000.71953170
57Rheumatoid arthritis_Homo sapiens_hsa053230.71271144
58Asthma_Homo sapiens_hsa053100.70594184
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69282447
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68413997
61Ether lipid metabolism_Homo sapiens_hsa005650.68293351
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67965092
63Malaria_Homo sapiens_hsa051440.66419127
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65062521
65Bladder cancer_Homo sapiens_hsa052190.64953729
66Vibrio cholerae infection_Homo sapiens_hsa051100.63635389
67Epstein-Barr virus infection_Homo sapiens_hsa051690.63285900
68Sphingolipid metabolism_Homo sapiens_hsa006000.63143212
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.62036182
70Glutathione metabolism_Homo sapiens_hsa004800.60933459
71Linoleic acid metabolism_Homo sapiens_hsa005910.60339524
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59591266
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58253659
74Tyrosine metabolism_Homo sapiens_hsa003500.56046026
75Cell cycle_Homo sapiens_hsa041100.54882679
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53438187
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53391151
78Regulation of autophagy_Homo sapiens_hsa041400.52905934
79Folate biosynthesis_Homo sapiens_hsa007900.52313413
80Pyruvate metabolism_Homo sapiens_hsa006200.49350931
81Hematopoietic cell lineage_Homo sapiens_hsa046400.48882343
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47596828
83One carbon pool by folate_Homo sapiens_hsa006700.44815799
84Systemic lupus erythematosus_Homo sapiens_hsa053220.43134081
85Phagosome_Homo sapiens_hsa041450.41478121
86Phenylalanine metabolism_Homo sapiens_hsa003600.41107844
87Apoptosis_Homo sapiens_hsa042100.39946298
88Nicotine addiction_Homo sapiens_hsa050330.38971784
89Serotonergic synapse_Homo sapiens_hsa047260.37189017
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35937644
91Other glycan degradation_Homo sapiens_hsa005110.35712323
92Type I diabetes mellitus_Homo sapiens_hsa049400.35256917
93Herpes simplex infection_Homo sapiens_hsa051680.34939099
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34211715
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.34170955
96Histidine metabolism_Homo sapiens_hsa003400.34043802
97HTLV-I infection_Homo sapiens_hsa051660.33143179
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32754102
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32467855
100p53 signaling pathway_Homo sapiens_hsa041150.31418550
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31195347
102Caffeine metabolism_Homo sapiens_hsa002320.30746913
103Prion diseases_Homo sapiens_hsa050200.29571976
104Measles_Homo sapiens_hsa051620.29402942
105Viral carcinogenesis_Homo sapiens_hsa052030.28689407
106Peroxisome_Homo sapiens_hsa041460.27956884
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27717116
108Alcoholism_Homo sapiens_hsa050340.27574147
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27020820
110Osteoclast differentiation_Homo sapiens_hsa043800.26516293
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.26157054
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25151977
113mRNA surveillance pathway_Homo sapiens_hsa030150.24650792
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.24284334
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23426183
116Sulfur metabolism_Homo sapiens_hsa009200.22812773
117N-Glycan biosynthesis_Homo sapiens_hsa005100.22811778
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22479524
119Sulfur relay system_Homo sapiens_hsa041220.22304952
120Steroid biosynthesis_Homo sapiens_hsa001000.21131087
121Antigen processing and presentation_Homo sapiens_hsa046120.20845605
122Tuberculosis_Homo sapiens_hsa051520.20754349
123Salmonella infection_Homo sapiens_hsa051320.19562348
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18690788
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17973211
126B cell receptor signaling pathway_Homo sapiens_hsa046620.17836047
127Legionellosis_Homo sapiens_hsa051340.17306314
128Toxoplasmosis_Homo sapiens_hsa051450.15965458
129Arginine and proline metabolism_Homo sapiens_hsa003300.15906020
130Pentose phosphate pathway_Homo sapiens_hsa000300.15845978
131Taste transduction_Homo sapiens_hsa047420.15707530
132Chemical carcinogenesis_Homo sapiens_hsa052040.14364571
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12545126
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.11761039
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11335795

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