MRPL24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.29033687
2doxorubicin metabolic process (GO:0044598)9.29033687
3daunorubicin metabolic process (GO:0044597)9.29033687
4aminoglycoside antibiotic metabolic process (GO:0030647)6.20047915
5ribosomal small subunit biogenesis (GO:0042274)5.52477663
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.25892386
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10782412
8negative regulation of epidermis development (GO:0045683)5.08865537
9maintenance of protein location in nucleus (GO:0051457)5.01707529
10somite rostral/caudal axis specification (GO:0032525)4.87275847
11rRNA methylation (GO:0031167)4.82052929
12rRNA modification (GO:0000154)4.73542982
13regulation of mitochondrial translation (GO:0070129)4.73457697
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.70845694
15rRNA transcription (GO:0009303)4.70673802
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.66320124
17protein localization to kinetochore (GO:0034501)4.57647618
18protein maturation by protein folding (GO:0022417)4.53815011
19negative regulation of epidermal cell differentiation (GO:0045605)4.47088241
20regulation of telomere maintenance via telomerase (GO:0032210)4.45899216
21regulation of response to osmotic stress (GO:0047484)4.44057481
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39042275
23ATP synthesis coupled proton transport (GO:0015986)4.39042275
24negative regulation of cell cycle G2/M phase transition (GO:1902750)4.35794209
25negative regulation of telomerase activity (GO:0051974)4.33265312
26formation of translation preinitiation complex (GO:0001731)4.14963470
27nucleobase-containing small molecule interconversion (GO:0015949)4.14889045
28quinone metabolic process (GO:1901661)4.13102497
29respiratory electron transport chain (GO:0022904)4.10666326
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08723273
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03706098
32histone H4-K12 acetylation (GO:0043983)4.03505826
33regulation of MHC class I biosynthetic process (GO:0045343)4.03404199
34DNA replication checkpoint (GO:0000076)4.02816120
35oxidative phosphorylation (GO:0006119)4.00834183
36electron transport chain (GO:0022900)4.00454425
37muscle organ morphogenesis (GO:0048644)3.91690675
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.91029438
39regulation of cilium movement (GO:0003352)3.90643656
40regulation of translation in response to stress (GO:0043555)3.85572022
41ribonucleoprotein complex biogenesis (GO:0022613)3.84027090
42DNA replication-dependent nucleosome assembly (GO:0006335)3.82543689
43DNA replication-dependent nucleosome organization (GO:0034723)3.82543689
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.82176289
45mitotic sister chromatid segregation (GO:0000070)3.82087692
46protein targeting to mitochondrion (GO:0006626)3.78430967
47viral transcription (GO:0019083)3.75025131
48negative regulation of telomere maintenance (GO:0032205)3.74105826
49proteasome assembly (GO:0043248)3.73800633
50cullin deneddylation (GO:0010388)3.73105364
51DNA damage response, detection of DNA damage (GO:0042769)3.66346690
52pseudouridine synthesis (GO:0001522)3.65781195
53GDP-mannose metabolic process (GO:0019673)3.65241120
54histone H4-K5 acetylation (GO:0043981)3.64385370
55histone H4-K8 acetylation (GO:0043982)3.64385370
56coenzyme catabolic process (GO:0009109)3.62972234
57ribosomal small subunit assembly (GO:0000028)3.62084877
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61715426
59chaperone-mediated protein transport (GO:0072321)3.58476788
60cytidine deamination (GO:0009972)3.58226882
61cytidine metabolic process (GO:0046087)3.58226882
62cytidine catabolic process (GO:0006216)3.58226882
63interferon-gamma production (GO:0032609)3.57915019
64translational termination (GO:0006415)3.57255302
65nucleoside transmembrane transport (GO:1901642)3.55097395
66heterochromatin organization (GO:0070828)3.53820789
67protein complex biogenesis (GO:0070271)3.51088129
68establishment of protein localization to mitochondrion (GO:0072655)3.48424634
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.47707796
70protein localization to chromosome, centromeric region (GO:0071459)3.47370134
71mitochondrial respiratory chain complex assembly (GO:0033108)3.46111679
72protein deneddylation (GO:0000338)3.43867482
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43534675
74positive regulation of DNA-dependent DNA replication (GO:2000105)3.43469207
75ribosome biogenesis (GO:0042254)3.43438298
76respiratory chain complex IV assembly (GO:0008535)3.42446805
77ribosomal large subunit biogenesis (GO:0042273)3.42141304
78maturation of SSU-rRNA (GO:0030490)3.41711534
79COPI coating of Golgi vesicle (GO:0048205)3.40413337
80Golgi transport vesicle coating (GO:0048200)3.40413337
81negative regulation of ligase activity (GO:0051352)3.40177629
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40177629
83regulation of translational fidelity (GO:0006450)3.39451828
84telomere maintenance via semi-conservative replication (GO:0032201)3.37609913
85NADH metabolic process (GO:0006734)3.37302673
86tricarboxylic acid cycle (GO:0006099)3.34277342
87protein localization to mitochondrion (GO:0070585)3.33691013
88notochord development (GO:0030903)3.32397941
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31050274
90regulation of cellular amino acid metabolic process (GO:0006521)3.30700362
91folic acid metabolic process (GO:0046655)3.30475783
92proline biosynthetic process (GO:0006561)3.30321341
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29404880
94phenol-containing compound catabolic process (GO:0019336)3.29007325
95primary alcohol catabolic process (GO:0034310)3.28897279
96cytochrome complex assembly (GO:0017004)3.28647067
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27009200
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26764251
99L-phenylalanine metabolic process (GO:0006558)3.26764251
100cotranslational protein targeting to membrane (GO:0006613)3.25235772
101cellular component biogenesis (GO:0044085)3.24729339
102DNA strand elongation involved in DNA replication (GO:0006271)3.24412193
103protein targeting to ER (GO:0045047)3.23655934
104guanosine-containing compound biosynthetic process (GO:1901070)3.19740372
105DNA strand elongation (GO:0022616)3.17048704
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16116648
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14529620
108hormone catabolic process (GO:0042447)3.13954751
109response to dietary excess (GO:0002021)3.13098631
110chromatin assembly (GO:0031497)3.12147305
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11932382
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11932382
113nuclear envelope reassembly (GO:0031468)3.11424824
114mitotic nuclear envelope reassembly (GO:0007084)3.11424824
115ribosome assembly (GO:0042255)3.10326162
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09522586
117transcription elongation from RNA polymerase III promoter (GO:0006385)3.09030216
118termination of RNA polymerase III transcription (GO:0006386)3.09030216
119mitochondrial respiratory chain complex I assembly (GO:0032981)3.08903844
120NADH dehydrogenase complex assembly (GO:0010257)3.08903844
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08903844
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07958534
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07958534
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07958534
125signal transduction involved in DNA damage checkpoint (GO:0072422)3.07692405
126signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07692405
127primitive streak formation (GO:0090009)3.07309186
128establishment of integrated proviral latency (GO:0075713)3.06129442
129tRNA aminoacylation for protein translation (GO:0006418)3.06017116
130protein localization to endoplasmic reticulum (GO:0070972)3.05698328
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05129565
132establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04505253
133mitochondrial transport (GO:0006839)3.03695623
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01521527
135tRNA aminoacylation (GO:0043039)3.00583406
136amino acid activation (GO:0043038)3.00583406
137nuclear pore complex assembly (GO:0051292)2.98453994
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.98132837
139translational elongation (GO:0006414)2.97734405
140peptidyl-histidine modification (GO:0018202)2.97362053
141sister chromatid segregation (GO:0000819)2.95893463
142positive regulation of ligase activity (GO:0051351)2.95698371
143aerobic respiration (GO:0009060)2.94989448
144GTP biosynthetic process (GO:0006183)2.93367060
145pteridine-containing compound biosynthetic process (GO:0042559)2.93307400
146UTP biosynthetic process (GO:0006228)2.92251355
147regulation of posttranscriptional gene silencing (GO:0060147)2.90174835
148regulation of gene silencing by miRNA (GO:0060964)2.90174835
149regulation of gene silencing by RNA (GO:0060966)2.90174835
150branching involved in mammary gland duct morphogenesis (GO:0060444)2.88309914
151purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87932538
152pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87190860
153regulation of telomerase activity (GO:0051972)2.85839028
154viral life cycle (GO:0019058)2.85082108
155cardiovascular system development (GO:0072358)2.80063639
156DNA replication initiation (GO:0006270)2.78660440
157intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.78094869
158translational initiation (GO:0006413)2.77472251
159transcription from mitochondrial promoter (GO:0006390)2.75754902
160rRNA processing (GO:0006364)2.74864247
161intestinal epithelial cell development (GO:0060576)2.73232145
162cellular modified amino acid catabolic process (GO:0042219)2.72824229
163cell fate commitment involved in formation of primary germ layer (GO:0060795)2.71395310
164positive regulation of defense response to virus by host (GO:0002230)2.71209089
165* translation (GO:0006412)2.69909811
166negative regulation of interleukin-2 production (GO:0032703)2.66267314
167mitochondrial DNA replication (GO:0006264)2.65639102
168negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.65109459
169nuclear pore organization (GO:0006999)2.65014530
170cellular protein complex disassembly (GO:0043624)2.63445343
171rRNA metabolic process (GO:0016072)2.63272301
172transcription from RNA polymerase I promoter (GO:0006360)2.62513007
173nucleoside transport (GO:0015858)2.62285521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.19278986
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.81065814
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.81065814
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.81065814
5E2F7_22180533_ChIP-Seq_HELA_Human4.81011229
6* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17410728
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.09334546
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91327601
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75288691
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.53220566
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.50591094
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50036648
13* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49576043
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36750253
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33578867
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32905267
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28532478
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27387443
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27112873
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26452704
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26118342
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.22687336
23ZNF263_19887448_ChIP-Seq_K562_Human2.19109918
24* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18985095
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.15301914
26IRF1_19129219_ChIP-ChIP_H3396_Human2.13745662
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.99562115
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99478622
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.98911694
30* ETS1_20019798_ChIP-Seq_JURKAT_Human1.95414846
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89478188
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86325701
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.85176704
34NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.82112539
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80775057
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80736465
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77997993
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77912932
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77855545
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70806606
41* FOXP3_21729870_ChIP-Seq_TREG_Human1.68932597
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67776189
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67009200
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66830973
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66268615
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65207943
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.64158057
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61865030
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61034991
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59232917
51* VDR_23849224_ChIP-Seq_CD4+_Human1.57043120
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53292244
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49972716
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46992344
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45576279
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44482229
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44274550
58* XRN2_22483619_ChIP-Seq_HELA_Human1.44044441
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.41469601
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39672673
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39081048
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37366652
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34065108
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32991863
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32499297
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31574699
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30937648
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30202534
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29542998
70TFEB_21752829_ChIP-Seq_HELA_Human1.28685797
71NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28395188
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26890698
73OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25483447
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.25409414
75* TTF2_22483619_ChIP-Seq_HELA_Human1.23877199
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22951925
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21357215
78* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20536814
79* DCP1A_22483619_ChIP-Seq_HELA_Human1.19164527
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18884912
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18708443
82* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18019729
83NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16692014
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.15959185
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15260077
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13906641
87ELK1_19687146_ChIP-ChIP_HELA_Human1.13691320
88* GABP_19822575_ChIP-Seq_HepG2_Human1.13364923
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13201583
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11463075
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11347981
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.10571860
93* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09918824
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09047628
95* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08862817
96RACK7_27058665_Chip-Seq_MCF-7_Human1.08602936
97VDR_21846776_ChIP-Seq_THP-1_Human1.08186205
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07092660
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07064870
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05853467
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05281586
102* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04264077
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04238313
104KDM5A_27292631_Chip-Seq_BREAST_Human1.04157383
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04003994
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03921355
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00870361
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00531361
109LXR_22292898_ChIP-Seq_THP-1_Human1.00397915
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00010450
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99584197
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98723353
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97776530
114TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97672787
115* ELK1_22589737_ChIP-Seq_MCF10A_Human0.97137923
116SCL_19346495_ChIP-Seq_HPC-7_Human0.96993398
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96358173
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96230781
119E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96222088
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95646913
121ATF3_27146783_Chip-Seq_COLON_Human0.94852194
122CIITA_25753668_ChIP-Seq_RAJI_Human0.94527866
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.94522211
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93672955
125* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93412735
126AR_21909140_ChIP-Seq_LNCAP_Human0.93090748
127* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92514600
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90641218
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89955618
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.86731045
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86536827
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.86301437
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84518947
134* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84387207
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84203182
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83648428
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83300755
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81567323
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.81446530
140* SPI1_23547873_ChIP-Seq_NB4_Human0.81100875
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80348194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.87685538
2MP0002254_reproductive_system_inflammat4.12870496
3MP0004264_abnormal_extraembryonic_tissu4.04026350
4MP0006292_abnormal_olfactory_placode4.02682442
5MP0005075_abnormal_melanosome_morpholog3.71971305
6MP0008057_abnormal_DNA_replication3.45900194
7MP0004957_abnormal_blastocyst_morpholog3.35495020
8MP0002877_abnormal_melanocyte_morpholog2.69514878
9MP0003890_abnormal_embryonic-extraembry2.62398423
10MP0004233_abnormal_muscle_weight2.57131721
11MP0005394_taste/olfaction_phenotype2.47947566
12MP0005499_abnormal_olfactory_system2.47947566
13MP0006035_abnormal_mitochondrial_morpho2.38453226
14MP0005408_hypopigmentation2.37924526
15MP0002332_abnormal_exercise_endurance2.35925400
16MP0001661_extended_life_span2.35601919
17MP0005451_abnormal_body_composition2.33144619
18MP0005171_absent_coat_pigmentation2.20746996
19MP0002277_abnormal_respiratory_mucosa2.14223251
20MP0003806_abnormal_nucleotide_metabolis2.09910087
21MP0004381_abnormal_hair_follicle2.08235727
22MP0005058_abnormal_lysosome_morphology2.06548267
23MP0000749_muscle_degeneration2.01028345
24MP0003077_abnormal_cell_cycle1.98114184
25MP0005330_cardiomyopathy1.96377490
26MP0000751_myopathy1.89868521
27MP0000678_abnormal_parathyroid_gland1.89000688
28MP0003693_abnormal_embryo_hatching1.88368422
29MP0000750_abnormal_muscle_regeneration1.79967458
30MP0006082_CNS_inflammation1.76040052
31MP0009840_abnormal_foam_cell1.73866739
32MP0002132_abnormal_respiratory_system1.72935430
33MP0002396_abnormal_hematopoietic_system1.71679974
34MP0005332_abnormal_amino_acid1.70745829
35MP0010094_abnormal_chromosome_stability1.68626900
36MP0003186_abnormal_redox_activity1.66249078
37MP0003111_abnormal_nucleus_morphology1.63774024
38MP0001853_heart_inflammation1.55518790
39MP0005670_abnormal_white_adipose1.52830655
40MP0005380_embryogenesis_phenotype1.51689075
41MP0001672_abnormal_embryogenesis/_devel1.51689075
42MP0003938_abnormal_ear_development1.48845135
43MP0003121_genomic_imprinting1.48212762
44MP0001764_abnormal_homeostasis1.47120145
45MP0005266_abnormal_metabolism1.46360565
46MP0006036_abnormal_mitochondrial_physio1.45520741
47MP0005083_abnormal_biliary_tract1.45127027
48MP0002653_abnormal_ependyma_morphology1.43400908
49MP0005257_abnormal_intraocular_pressure1.42803882
50MP0009379_abnormal_foot_pigmentation1.42727338
51MP0001881_abnormal_mammary_gland1.42643582
52MP0005501_abnormal_skin_physiology1.41889913
53MP0000350_abnormal_cell_proliferation1.39251441
54MP0000003_abnormal_adipose_tissue1.38146977
55MP0000747_muscle_weakness1.37368438
56MP0003950_abnormal_plasma_membrane1.36910108
57MP0000490_abnormal_crypts_of1.35985101
58MP0002088_abnormal_embryonic_growth/wei1.35555343
59MP0003984_embryonic_growth_retardation1.34907660
60MP0003122_maternal_imprinting1.34806287
61MP0009697_abnormal_copulation1.33923545
62MP0003136_yellow_coat_color1.33091425
63MP0008932_abnormal_embryonic_tissue1.32203225
64MP0008058_abnormal_DNA_repair1.29359159
65MP0005360_urolithiasis1.29233001
66MP0002127_abnormal_cardiovascular_syste1.29158371
67MP0002269_muscular_atrophy1.28206423
68MP0010352_gastrointestinal_tract_polyps1.24645792
69MP0004133_heterotaxia1.23841657
70MP0001293_anophthalmia1.23699039
71MP0003315_abnormal_perineum_morphology1.22200252
72MP0000759_abnormal_skeletal_muscle1.21131022
73MP0010234_abnormal_vibrissa_follicle1.20966590
74MP0002139_abnormal_hepatobiliary_system1.20114997
75MP0000762_abnormal_tongue_morphology1.19251862
76MP0009333_abnormal_splenocyte_physiolog1.17419729
77MP0004185_abnormal_adipocyte_glucose1.17075312
78MP0008438_abnormal_cutaneous_collagen1.15896055
79MP0005379_endocrine/exocrine_gland_phen1.14566994
80MP0005365_abnormal_bile_salt1.14031604
81MP0005165_increased_susceptibility_to1.12597897
82MP0003786_premature_aging1.11686908
83MP0008789_abnormal_olfactory_epithelium1.11609906
84MP0004043_abnormal_pH_regulation1.10758418
85MP0008007_abnormal_cellular_replicative1.09690753
86MP0000313_abnormal_cell_death1.08229202
87MP0005584_abnormal_enzyme/coenzyme_acti1.08002098
88MP0004858_abnormal_nervous_system1.06125692
89MP0000013_abnormal_adipose_tissue1.05621376
90MP0002163_abnormal_gland_morphology1.04021770
91MP0003183_abnormal_peptide_metabolism1.02516444
92MP0002092_abnormal_eye_morphology1.02474339
93MP0002060_abnormal_skin_morphology1.00061234
94MP0001849_ear_inflammation0.97717494
95MP0000015_abnormal_ear_pigmentation0.97676687
96MP0001730_embryonic_growth_arrest0.96095268
97MP0002086_abnormal_extraembryonic_tissu0.94300222
98MP0000049_abnormal_middle_ear0.93695968
99MP0002085_abnormal_embryonic_tissue0.93370742
100MP0001727_abnormal_embryo_implantation0.92957819
101MP0003123_paternal_imprinting0.92915624
102MP0005623_abnormal_meninges_morphology0.92607117
103MP0000371_diluted_coat_color0.91824395
104MP0002098_abnormal_vibrissa_morphology0.91621265
105MP0000343_altered_response_to0.91530720
106MP0005375_adipose_tissue_phenotype0.89539956
107MP0005636_abnormal_mineral_homeostasis0.87107538
108MP0001186_pigmentation_phenotype0.86199291
109MP0000627_abnormal_mammary_gland0.85413895
110MP0009643_abnormal_urine_homeostasis0.85348052
111MP0000609_abnormal_liver_physiology0.84668628
112MP0002019_abnormal_tumor_incidence0.84343329
113MP0004147_increased_porphyrin_level0.84211061
114MP0002722_abnormal_immune_system0.83247784
115MP0008875_abnormal_xenobiotic_pharmacok0.83212868
116MP0000689_abnormal_spleen_morphology0.81249065
117MP0001905_abnormal_dopamine_level0.80877790
118MP0002970_abnormal_white_adipose0.80805351
119MP0004087_abnormal_muscle_fiber0.79491973
120MP0002932_abnormal_joint_morphology0.79359320
121MP0005671_abnormal_response_to0.78734922
122MP0001835_abnormal_antigen_presentation0.78451859
123MP0003718_maternal_effect0.78243925
124MP0005666_abnormal_adipose_tissue0.78171831
125MP0003191_abnormal_cellular_cholesterol0.76628789
126MP0005319_abnormal_enzyme/_coenzyme0.76389154
127MP0004782_abnormal_surfactant_physiolog0.75433413
128MP0002080_prenatal_lethality0.74523559
129MP0001216_abnormal_epidermal_layer0.74226077
130MP0008260_abnormal_autophagy0.74223885
131MP0009765_abnormal_xenobiotic_induced0.73388091
132MP0001243_abnormal_dermal_layer0.73333628
133MP0002095_abnormal_skin_pigmentation0.73169221
134MP0003656_abnormal_erythrocyte_physiolo0.72501989
135MP0002084_abnormal_developmental_patter0.71543191
136MP0000372_irregular_coat_pigmentation0.71440747
137MP0005376_homeostasis/metabolism_phenot0.70597904
138MP0010771_integument_phenotype0.70304788
139MP0003959_abnormal_lean_body0.70177444
140MP0001697_abnormal_embryo_size0.70047469
141MP0002075_abnormal_coat/hair_pigmentati0.69518081
142MP0002160_abnormal_reproductive_system0.69515549
143MP0000858_altered_metastatic_potential0.69486258
144MP0002429_abnormal_blood_cell0.69098967
145MP0000358_abnormal_cell_content/0.69087933
146MP0001800_abnormal_humoral_immune0.68913639
147MP0000383_abnormal_hair_follicle0.68543189
148MP0003763_abnormal_thymus_physiology0.67224683
149MP0002114_abnormal_axial_skeleton0.66926783
150MP0005391_vision/eye_phenotype0.66485507
151MP0010030_abnormal_orbit_morphology0.65385547
152MP0008873_increased_physiological_sensi0.65328300
153MP0002796_impaired_skin_barrier0.64948413
154MP0000377_abnormal_hair_follicle0.63737519
155MP0008961_abnormal_basal_metabolism0.63554033
156MP0000432_abnormal_head_morphology0.63522636
157MP0005025_abnormal_response_to0.63299678
158MP0003705_abnormal_hypodermis_morpholog0.63296556
159MP0002405_respiratory_system_inflammati0.62577773
160MP0002233_abnormal_nose_morphology0.61935351
161MP0005023_abnormal_wound_healing0.60316733
162MP0001145_abnormal_male_reproductive0.59973136
163MP0000716_abnormal_immune_system0.59716327
164MP0002938_white_spotting0.59515574

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.00924537
2Multiple enchondromatosis (HP:0005701)5.74103666
3Hypochromic microcytic anemia (HP:0004840)5.11541511
4Abnormal mitochondria in muscle tissue (HP:0008316)5.04035119
5Acute necrotizing encephalopathy (HP:0006965)4.96959496
6Acute encephalopathy (HP:0006846)4.69474883
7Mitochondrial inheritance (HP:0001427)4.66670638
8Hepatocellular necrosis (HP:0001404)4.44834392
9Hepatic necrosis (HP:0002605)4.34115825
10Increased CSF lactate (HP:0002490)4.28784317
11Increased intramyocellular lipid droplets (HP:0012240)4.11276768
12Progressive macrocephaly (HP:0004481)4.01106529
13Rib fusion (HP:0000902)3.86093448
14Increased muscle lipid content (HP:0009058)3.83556238
15Increased hepatocellular lipid droplets (HP:0006565)3.80208811
16Cerebral edema (HP:0002181)3.72156733
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.70565173
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.70565173
19Lipid accumulation in hepatocytes (HP:0006561)3.66410652
20Hepatoblastoma (HP:0002884)3.61644587
21Ependymoma (HP:0002888)3.60807477
22Reduced antithrombin III activity (HP:0001976)3.56967480
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56625268
24Exercise intolerance (HP:0003546)3.56258385
253-Methylglutaconic aciduria (HP:0003535)3.46646790
26Chromsome breakage (HP:0040012)3.42689238
27Rhabdomyosarcoma (HP:0002859)3.42619996
28Lactic acidosis (HP:0003128)3.36895792
29Nephroblastoma (Wilms tumor) (HP:0002667)3.36845305
30Increased serum lactate (HP:0002151)3.33996696
31Partial duplication of thumb phalanx (HP:0009944)3.33909673
32Hypoplasia of the fovea (HP:0007750)3.32517492
33Aplasia/Hypoplasia of the fovea (HP:0008060)3.32517492
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.31219413
35Testicular atrophy (HP:0000029)3.18245875
36Neoplasm of striated muscle (HP:0009728)3.16636774
37Trismus (HP:0000211)3.12977290
38Embryonal renal neoplasm (HP:0011794)3.07757976
39Abnormal lung lobation (HP:0002101)3.06869047
40Rectovaginal fistula (HP:0000143)3.06814896
41Rectal fistula (HP:0100590)3.06814896
42Respiratory failure (HP:0002878)3.06479746
43Microvesicular hepatic steatosis (HP:0001414)3.03915625
44Abnormality of the salivary glands (HP:0010286)3.03839583
45Type I transferrin isoform profile (HP:0003642)2.97402026
46Aplastic anemia (HP:0001915)2.94714177
47Ragged-red muscle fibers (HP:0003200)2.89010398
48Anomalous pulmonary venous return (HP:0010772)2.88632285
49Fused cervical vertebrae (HP:0002949)2.87956384
50Abnormal hemoglobin (HP:0011902)2.86424959
51Abnormal cartilage morphology (HP:0002763)2.85994781
52Abnormality of cells of the erythroid lineage (HP:0012130)2.85606163
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83605466
54Partial duplication of the phalanx of hand (HP:0009999)2.83086728
55Abnormality of the lower motor neuron (HP:0002366)2.82328051
56Hypochromic anemia (HP:0001931)2.79122091
57Cholecystitis (HP:0001082)2.77126643
58Abnormal gallbladder physiology (HP:0012438)2.77126643
59Abnormality of glycolysis (HP:0004366)2.75423787
60Increased serum pyruvate (HP:0003542)2.75423787
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72875665
62Vertebral compression fractures (HP:0002953)2.71198628
63Rhabdomyolysis (HP:0003201)2.67659862
64Respiratory difficulties (HP:0002880)2.63180549
65Hyperinsulinemic hypoglycemia (HP:0000825)2.63127899
66Hypokinesia (HP:0002375)2.63126747
67Vaginal fistula (HP:0004320)2.62995936
68Nasolacrimal duct obstruction (HP:0000579)2.61928817
69Intestinal fistula (HP:0100819)2.57785134
70Abnormal number of erythroid precursors (HP:0012131)2.54273143
71Bifid tongue (HP:0010297)2.52941791
72Abnormality of the fovea (HP:0000493)2.51064228
73Meckel diverticulum (HP:0002245)2.50201457
74Combined immunodeficiency (HP:0005387)2.49267099
75Supernumerary spleens (HP:0009799)2.49071278
76Microretrognathia (HP:0000308)2.48976676
77Abnormality of the pulmonary veins (HP:0011718)2.47228383
78Abnormality of placental membranes (HP:0011409)2.40891552
79Amniotic constriction ring (HP:0009775)2.40891552
80Abnormality of the ileum (HP:0001549)2.38668966
81Lethargy (HP:0001254)2.36814750
82Myoglobinuria (HP:0002913)2.36270758
83Premature ovarian failure (HP:0008209)2.35977677
84Esophageal neoplasm (HP:0100751)2.35095855
85Neoplasm of head and neck (HP:0012288)2.35095855
86Progressive muscle weakness (HP:0003323)2.34102155
87Impulsivity (HP:0100710)2.32302529
88Sensory axonal neuropathy (HP:0003390)2.31518210
89Rough bone trabeculation (HP:0100670)2.30889180
90Aplasia/hypoplasia of the humerus (HP:0006507)2.28567705
91Renal Fanconi syndrome (HP:0001994)2.25821012
92Cheilitis (HP:0100825)2.25545668
93Spastic paraparesis (HP:0002313)2.25053115
94Reticulocytopenia (HP:0001896)2.24555168
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.24057619
96Leukodystrophy (HP:0002415)2.23609174
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21710273
98Dicarboxylic aciduria (HP:0003215)2.21710273
99Glossoptosis (HP:0000162)2.20254221
100Progressive external ophthalmoplegia (HP:0000590)2.20198768
101CNS demyelination (HP:0007305)2.19763293
102Hyperammonemia (HP:0001987)2.18877591
103Abnormality of small intestinal villus morphology (HP:0011472)2.18143997
104Villous atrophy (HP:0011473)2.18143997
105Generalized aminoaciduria (HP:0002909)2.16300782
106Exertional dyspnea (HP:0002875)2.16209683
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15047984
108Sparse eyelashes (HP:0000653)2.14215247
109Aplasia/Hypoplasia of the macula (HP:0008059)2.11785347
110Cholelithiasis (HP:0001081)2.10024706
111Opisthotonus (HP:0002179)2.08071346
112Emotional lability (HP:0000712)2.07899278
113Pallor (HP:0000980)2.06430837
114Abnormality of the intrinsic pathway (HP:0010989)2.05246304
115Pendular nystagmus (HP:0012043)2.05179057
116Secondary amenorrhea (HP:0000869)2.02693634
117Nasal polyposis (HP:0100582)2.01933929
118Preauricular skin tag (HP:0000384)2.00687220
119Horizontal nystagmus (HP:0000666)2.00193127
120Short humerus (HP:0005792)1.97247077
121Abnormality of the anterior horn cell (HP:0006802)1.96815349
122Degeneration of anterior horn cells (HP:0002398)1.96815349
123Malnutrition (HP:0004395)1.96732607
124Tongue fasciculations (HP:0001308)1.93521682
125Pancytopenia (HP:0001876)1.92875154
126Duplication of thumb phalanx (HP:0009942)1.90571310
127Duodenal stenosis (HP:0100867)1.90536693
128Small intestinal stenosis (HP:0012848)1.90536693
129Periauricular skin pits (HP:0100277)1.89159314
130Preauricular pit (HP:0004467)1.89159314
131Macrocytic anemia (HP:0001972)1.89141611
132Abnormalities of placenta or umbilical cord (HP:0001194)1.88594685
133Cerebral hypomyelination (HP:0006808)1.88430739
134Abnormality of renal resorption (HP:0011038)1.88402959
135Abnormality of the preputium (HP:0100587)1.87851937
136Facial cleft (HP:0002006)1.87814226
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87439465
138Abnormal gallbladder morphology (HP:0012437)1.87410810
139Generalized amyotrophy (HP:0003700)1.84882309
140Myelodysplasia (HP:0002863)1.84442644
141Abnormality of fatty-acid metabolism (HP:0004359)1.83401953
142Large earlobe (HP:0009748)1.82856076
143Abnormal protein glycosylation (HP:0012346)1.82140118
144Abnormal glycosylation (HP:0012345)1.82140118
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82140118
146Abnormal protein N-linked glycosylation (HP:0012347)1.82140118
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.81767124
148Abnormality of the astrocytes (HP:0100707)1.80510343
149Astrocytoma (HP:0009592)1.80510343
150Abnormality of methionine metabolism (HP:0010901)1.79470519
151Abnormality of the lacrimal duct (HP:0011481)1.79436979
152Gout (HP:0001997)1.78563709
153Cleft eyelid (HP:0000625)1.77667078
154Cutaneous melanoma (HP:0012056)1.77547470
155Reduced subcutaneous adipose tissue (HP:0003758)1.76597933
156Abnormal trabecular bone morphology (HP:0100671)1.76064339
157Abnormality of the phalanges of the hallux (HP:0010057)1.74893642
158Hyperglycinuria (HP:0003108)1.74628857
159Upper motor neuron abnormality (HP:0002127)1.73984206
160Optic disc pallor (HP:0000543)1.73563519
161Distal lower limb muscle weakness (HP:0009053)1.71666266
162Myopathic facies (HP:0002058)1.71590892
163Vomiting (HP:0002013)1.71526308
164Exercise-induced myalgia (HP:0003738)1.69378958
165Unilateral renal agenesis (HP:0000122)1.68952667
166Oral leukoplakia (HP:0002745)1.68425418
167Abnormality of alanine metabolism (HP:0010916)1.68238149
168Hyperalaninemia (HP:0003348)1.68238149
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68238149
170Squamous cell carcinoma (HP:0002860)1.67987283
171Entropion (HP:0000621)1.67186458
172Diminished movement (HP:0002374)1.65813191
173Abnormality of the umbilical cord (HP:0010881)1.62469032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.76726838
2VRK24.81945413
3GRK54.42763388
4GRK63.99087146
5ERN13.77986785
6ADRBK23.38724676
7GRK73.02120818
8GRK12.99968644
9NEK12.89382499
10CSF1R2.86194941
11TTK2.83127029
12PDK22.54607518
13TGFBR22.46552140
14TESK12.45300786
15STK102.36584209
16MST1R2.14739013
17MAPK72.03359162
18MATK2.01134299
19SCYL21.89589065
20NME21.88593103
21MOS1.87750561
22LIMK11.87418335
23SMG11.80434114
24TYRO31.78303052
25CCNB11.78080403
26CDK71.69443722
27BUB11.64501611
28SRPK11.59357467
29EPHA21.54647582
30WEE11.52465692
31MST41.49219437
32ARAF1.47202505
33WNK11.45022656
34MAPKAPK31.44830280
35MAP2K61.39695429
36ILK1.39199358
37TRIB31.36310364
38PRKG21.35947025
39EIF2AK21.33693759
40PLK11.33098047
41ABL21.28029774
42CHEK21.26215555
43PHKG21.25075915
44PHKG11.25075915
45RPS6KB21.22655834
46BRSK11.12818796
47MAP3K121.11036238
48PAK41.09996363
49DAPK11.09631633
50EIF2AK11.08679718
51PRKD31.06693439
52ADRBK11.06499072
53BCKDK1.06341002
54STK160.99178452
55CDC70.97082350
56CAMK40.95443220
57AKT30.93309964
58TSSK60.93153362
59LRRK20.92941452
60LMTK20.87625070
61TLK10.87576669
62EIF2AK30.87280310
63PBK0.87171753
64IKBKB0.85402934
65TAOK20.84857018
66MARK20.83661182
67CSNK1G30.81384215
68DAPK30.80877152
69CSK0.79741356
70NEK20.78968625
71KDR0.77842296
72VRK10.77500097
73HIPK20.76992156
74SIK10.73438223
75CHEK10.71473589
76ICK0.71157203
77BLK0.70453935
78AURKA0.69931715
79CAMK2G0.69897432
80AURKB0.69561269
81MYLK0.67896379
82IRAK30.67770864
83FLT30.67513569
84IRAK40.67231539
85MUSK0.62235465
86MAP2K40.60348574
87MET0.59098093
88MAP3K80.58770119
89MAPKAPK50.58490719
90TESK20.58452506
91BRAF0.56668091
92AKT20.55205710
93CSNK1A1L0.54810735
94PLK30.53288398
95ACVR1B0.52729463
96PRKCI0.50610463
97STK40.50235336
98ERBB40.49077246
99DYRK30.48773926
100MAPK120.47586359
101TTN0.47408768
102ITK0.47081647
103MAP3K30.46553575
104RPS6KA50.45704000
105FGFR30.45680981
106ZAP700.44157813
107MAP3K110.44122052
108TAF10.43902084
109PTK20.43780131
110CDK40.43418347
111PIM20.42710056
112PAK10.42121054
113NUAK10.41350602
114CDK80.40325964
115MAP2K30.39593444
116KIT0.39557178
117PRKCD0.39374578
118CDK20.39015278
119RAF10.37630941
120NTRK10.36838527
121MAP4K10.36509783
122MAPK110.36250723
123CSNK1G10.35838594
124NME10.35343052
125NLK0.34342165
126ATM0.33921971
127CAMK2D0.33568864
128PIM10.31710758
129CDK90.31167917
130DYRK20.31019462
131EEF2K0.30782063
132BRSK20.30757318
133PASK0.30267266
134CSNK2A10.29303625
135OBSCN0.28953319
136TBK10.28725604
137IGF1R0.27921481
138MAP3K100.25971446
139CSNK2A20.25297047
140DMPK0.23907937
141MELK0.23864565
142RPS6KA40.23758757
143MAP2K20.23455989
144SIK30.23363572
145TYK20.23361548
146LCK0.23068001
147STK390.22649797
148YES10.22546449
149ATR0.21181393
150MAPK40.20776013
151MKNK10.20562947
152ZAK0.20321534
153PLK40.20105779
154MAP3K70.19117039
155ALK0.19033686
156CSNK1E0.18065791
157PDK30.17435862

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030104.28993406
2Vitamin B6 metabolism_Homo sapiens_hsa007504.04208856
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56443148
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.37235283
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.94389912
6RNA polymerase_Homo sapiens_hsa030202.43298666
7Fructose and mannose metabolism_Homo sapiens_hsa000512.40088278
8DNA replication_Homo sapiens_hsa030302.39437910
9Proteasome_Homo sapiens_hsa030502.36690316
10Arachidonic acid metabolism_Homo sapiens_hsa005902.29153631
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28958679
12Mismatch repair_Homo sapiens_hsa034302.24494842
13Homologous recombination_Homo sapiens_hsa034402.17429515
14Linoleic acid metabolism_Homo sapiens_hsa005911.96250882
15RNA transport_Homo sapiens_hsa030131.83023263
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80679865
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74626593
18Fanconi anemia pathway_Homo sapiens_hsa034601.72747805
19Folate biosynthesis_Homo sapiens_hsa007901.65891369
20Spliceosome_Homo sapiens_hsa030401.61886389
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59849649
22Pyrimidine metabolism_Homo sapiens_hsa002401.57384368
23One carbon pool by folate_Homo sapiens_hsa006701.56543648
24Oxidative phosphorylation_Homo sapiens_hsa001901.51323625
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49488333
26Sulfur metabolism_Homo sapiens_hsa009201.47878770
27Galactose metabolism_Homo sapiens_hsa000521.45075338
28Sulfur relay system_Homo sapiens_hsa041221.42605601
29RNA degradation_Homo sapiens_hsa030181.41240068
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41182365
31Base excision repair_Homo sapiens_hsa034101.40968518
32Chemical carcinogenesis_Homo sapiens_hsa052041.40190744
33Basal transcription factors_Homo sapiens_hsa030221.34316123
34Parkinsons disease_Homo sapiens_hsa050121.31989702
35Non-homologous end-joining_Homo sapiens_hsa034501.31257770
36Nucleotide excision repair_Homo sapiens_hsa034201.30650381
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19933371
38Other glycan degradation_Homo sapiens_hsa005111.17732660
39N-Glycan biosynthesis_Homo sapiens_hsa005101.10031983
40Huntingtons disease_Homo sapiens_hsa050161.06262735
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05001519
42Protein export_Homo sapiens_hsa030601.04751281
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.00265994
44Pentose phosphate pathway_Homo sapiens_hsa000300.98210645
45Ether lipid metabolism_Homo sapiens_hsa005650.97245284
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97155675
47Arginine and proline metabolism_Homo sapiens_hsa003300.93378863
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93348361
49Cell cycle_Homo sapiens_hsa041100.91577436
50Fatty acid metabolism_Homo sapiens_hsa012120.91300957
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90440112
52mRNA surveillance pathway_Homo sapiens_hsa030150.89944414
53Tryptophan metabolism_Homo sapiens_hsa003800.89470491
54Cardiac muscle contraction_Homo sapiens_hsa042600.88831606
55Arginine biosynthesis_Homo sapiens_hsa002200.88380910
56Glutathione metabolism_Homo sapiens_hsa004800.87271913
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86221058
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83297696
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83137593
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82256336
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82216254
62Retinol metabolism_Homo sapiens_hsa008300.78872642
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77829202
64Metabolic pathways_Homo sapiens_hsa011000.75785339
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.74121666
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73516085
67Alzheimers disease_Homo sapiens_hsa050100.72556639
68Carbon metabolism_Homo sapiens_hsa012000.72451046
69Butanoate metabolism_Homo sapiens_hsa006500.69037672
70Primary immunodeficiency_Homo sapiens_hsa053400.68085969
71Thyroid cancer_Homo sapiens_hsa052160.67031175
72Fatty acid elongation_Homo sapiens_hsa000620.64318941
73Herpes simplex infection_Homo sapiens_hsa051680.64157264
74Selenocompound metabolism_Homo sapiens_hsa004500.63836508
75Purine metabolism_Homo sapiens_hsa002300.63317088
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.61340313
77p53 signaling pathway_Homo sapiens_hsa041150.60448020
78Tyrosine metabolism_Homo sapiens_hsa003500.60100303
79Vibrio cholerae infection_Homo sapiens_hsa051100.58893534
80Histidine metabolism_Homo sapiens_hsa003400.58625680
81Peroxisome_Homo sapiens_hsa041460.57740377
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57437577
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55672608
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54187223
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.52225055
86Regulation of autophagy_Homo sapiens_hsa041400.50349449
87Steroid biosynthesis_Homo sapiens_hsa001000.49075745
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.48934020
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48243748
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46700354
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45748474
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.44537016
93Biosynthesis of amino acids_Homo sapiens_hsa012300.43352730
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39589005
95Complement and coagulation cascades_Homo sapiens_hsa046100.39400583
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38855705
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33866074
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.32744653
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.32689230
100Phenylalanine metabolism_Homo sapiens_hsa003600.31809212
101beta-Alanine metabolism_Homo sapiens_hsa004100.30688061
102Hematopoietic cell lineage_Homo sapiens_hsa046400.30529880
103Propanoate metabolism_Homo sapiens_hsa006400.28222596
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27730791
105Fatty acid degradation_Homo sapiens_hsa000710.27109413
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24551543
107Pyruvate metabolism_Homo sapiens_hsa006200.23878916
108Epstein-Barr virus infection_Homo sapiens_hsa051690.23833485
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23239077
110Prion diseases_Homo sapiens_hsa050200.21980338
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.21590779
112Ovarian steroidogenesis_Homo sapiens_hsa049130.20496865
113Apoptosis_Homo sapiens_hsa042100.20420667
114Antigen processing and presentation_Homo sapiens_hsa046120.20377092
115Bladder cancer_Homo sapiens_hsa052190.19464751
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18642740
117Inositol phosphate metabolism_Homo sapiens_hsa005620.17348429
118Lysosome_Homo sapiens_hsa041420.14958703
119Systemic lupus erythematosus_Homo sapiens_hsa053220.14315376
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.14011449
121Collecting duct acid secretion_Homo sapiens_hsa049660.13628341
122Sphingolipid metabolism_Homo sapiens_hsa006000.11623152
123PPAR signaling pathway_Homo sapiens_hsa033200.11157456
124Starch and sucrose metabolism_Homo sapiens_hsa005000.10149098

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »