MRPL27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.33560573
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.00178580
3ATP synthesis coupled proton transport (GO:0015986)8.00178580
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.55101806
5respiratory electron transport chain (GO:0022904)6.71665948
6electron transport chain (GO:0022900)6.54839172
7protein neddylation (GO:0045116)5.87511196
8chaperone-mediated protein transport (GO:0072321)5.53336954
9protein complex biogenesis (GO:0070271)5.21784466
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.07465068
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.07465068
12NADH dehydrogenase complex assembly (GO:0010257)5.07465068
13proteasome assembly (GO:0043248)4.81976055
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.74356952
15mitochondrial respiratory chain complex assembly (GO:0033108)4.63911746
16dopamine transport (GO:0015872)4.39158082
17rRNA modification (GO:0000154)4.17618273
18hydrogen ion transmembrane transport (GO:1902600)4.14811241
19regulation of mitochondrial translation (GO:0070129)4.08353275
20fatty acid elongation (GO:0030497)4.06478321
21ATP biosynthetic process (GO:0006754)4.04980384
22ribosomal small subunit assembly (GO:0000028)4.01446351
23purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.00960346
24maturation of SSU-rRNA (GO:0030490)3.97074456
25purine nucleoside triphosphate biosynthetic process (GO:0009145)3.96768634
26GTP biosynthetic process (GO:0006183)3.86890215
27viral transcription (GO:0019083)3.86637048
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.86029608
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83440242
30translational termination (GO:0006415)3.81233328
31proton transport (GO:0015992)3.78103585
32protein targeting to ER (GO:0045047)3.76592074
33positive regulation of ligase activity (GO:0051351)3.72017651
34hydrogen transport (GO:0006818)3.70812920
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66210741
36ribosomal large subunit biogenesis (GO:0042273)3.63207886
37pseudouridine synthesis (GO:0001522)3.61770055
38oxidative phosphorylation (GO:0006119)3.60973723
39regulation of cellular amino acid metabolic process (GO:0006521)3.60948739
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.59978484
41termination of RNA polymerase III transcription (GO:0006386)3.59978484
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.59619049
43protein localization to endoplasmic reticulum (GO:0070972)3.58385872
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58299381
45aldehyde catabolic process (GO:0046185)3.55715250
46ribonucleoside triphosphate biosynthetic process (GO:0009201)3.50356873
47inner mitochondrial membrane organization (GO:0007007)3.47799758
48respiratory chain complex IV assembly (GO:0008535)3.47565505
49regulation of ubiquitin-protein transferase activity (GO:0051438)3.45005048
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44462766
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44462766
52protein targeting to mitochondrion (GO:0006626)3.43390010
53cellular component biogenesis (GO:0044085)3.41816770
54cullin deneddylation (GO:0010388)3.41762625
55establishment of protein localization to mitochondrion (GO:0072655)3.39473916
56chromatin remodeling at centromere (GO:0031055)3.39278295
57CENP-A containing nucleosome assembly (GO:0034080)3.39263070
58translational elongation (GO:0006414)3.38465403
59spliceosomal snRNP assembly (GO:0000387)3.38110072
60DNA damage response, detection of DNA damage (GO:0042769)3.37601460
61long-chain fatty acid biosynthetic process (GO:0042759)3.36768543
62regulation of ligase activity (GO:0051340)3.35005372
63ribosomal small subunit biogenesis (GO:0042274)3.33023783
64cytochrome complex assembly (GO:0017004)3.32238933
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29929908
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28781990
67rRNA methylation (GO:0031167)3.27504620
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26501086
69protein deneddylation (GO:0000338)3.25442557
70translational initiation (GO:0006413)3.23735988
717-methylguanosine mRNA capping (GO:0006370)3.23722302
72regulation of oxidative phosphorylation (GO:0002082)3.21727528
73RNA capping (GO:0036260)3.19678539
747-methylguanosine RNA capping (GO:0009452)3.19678539
75rRNA processing (GO:0006364)3.17536057
76nucleoside triphosphate biosynthetic process (GO:0009142)3.15775373
77aerobic respiration (GO:0009060)3.15531711
78protein localization to mitochondrion (GO:0070585)3.15290259
79ATP hydrolysis coupled proton transport (GO:0015991)3.15096707
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.15096707
81kinetochore assembly (GO:0051382)3.12883854
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.11818978
83axon ensheathment in central nervous system (GO:0032291)3.11187360
84central nervous system myelination (GO:0022010)3.11187360
85intracellular protein transmembrane import (GO:0044743)3.09594179
86UTP biosynthetic process (GO:0006228)3.08592716
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08345636
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06429762
89mitochondrial transport (GO:0006839)3.06318535
90positive regulation of cell cycle arrest (GO:0071158)3.05320565
91regulation of cellular amine metabolic process (GO:0033238)3.05151842
92ribonucleoprotein complex biogenesis (GO:0022613)3.03105979
93rRNA metabolic process (GO:0016072)3.02447788
94negative regulation of ligase activity (GO:0051352)3.02086581
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02086581
96viral life cycle (GO:0019058)2.99823279
97amino acid salvage (GO:0043102)2.97473635
98L-methionine salvage (GO:0071267)2.97473635
99L-methionine biosynthetic process (GO:0071265)2.97473635
100metallo-sulfur cluster assembly (GO:0031163)2.96514482
101iron-sulfur cluster assembly (GO:0016226)2.96514482
102cholesterol biosynthetic process (GO:0006695)2.95913891
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95794504
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95794504
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95225575
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95225575
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95225575
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94684779
109positive regulation of mitochondrial fission (GO:0090141)2.93003851
110regulation of cellular respiration (GO:0043457)2.91883847
111guanosine-containing compound biosynthetic process (GO:1901070)2.90650501
112dopamine biosynthetic process (GO:0042416)2.89940363
113peptidyl-histidine modification (GO:0018202)2.89314374
114protein-cofactor linkage (GO:0018065)2.86596706
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85866575
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.82560809
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82560809
118signal transduction involved in cell cycle checkpoint (GO:0072395)2.80601740
119substantia nigra development (GO:0021762)2.78498646
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74564881
121CTP metabolic process (GO:0046036)2.72708036
122CTP biosynthetic process (GO:0006241)2.72708036
123mannosylation (GO:0097502)2.69741149
124establishment of viral latency (GO:0019043)2.69302803
125UTP metabolic process (GO:0046051)2.65276229
126nucleoside diphosphate phosphorylation (GO:0006165)2.64174742
127sterol biosynthetic process (GO:0016126)2.64069104
128* translation (GO:0006412)2.60696416
129nucleotide transmembrane transport (GO:1901679)2.59205203
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59064753
131establishment of integrated proviral latency (GO:0075713)2.58991119
132quinone biosynthetic process (GO:1901663)2.58372668
133ubiquinone biosynthetic process (GO:0006744)2.58372668
134GPI anchor biosynthetic process (GO:0006506)2.56523055
135cotranslational protein targeting to membrane (GO:0006613)2.55784090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.99171936
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.50853419
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.80518943
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.67479142
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50743266
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.46727629
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45992346
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08484531
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98239523
10E2F7_22180533_ChIP-Seq_HELA_Human2.97690453
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.81324090
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74129423
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73745461
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.69581065
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50741175
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45222265
17TAF15_26573619_Chip-Seq_HEK293_Human2.43271511
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35440652
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34804804
20* SRF_21415370_ChIP-Seq_HL-1_Mouse2.33465368
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.20202543
22VDR_22108803_ChIP-Seq_LS180_Human2.10196345
23GBX2_23144817_ChIP-Seq_PC3_Human2.07350457
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02662727
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99982111
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82483700
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82071782
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80407442
29IRF1_19129219_ChIP-ChIP_H3396_Human1.76367612
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75996874
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75555924
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.68646813
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67017743
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.66032364
35DCP1A_22483619_ChIP-Seq_HELA_Human1.65514719
36* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65282330
37* VDR_23849224_ChIP-Seq_CD4+_Human1.64875985
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64613447
39ELK1_19687146_ChIP-ChIP_HELA_Human1.64022454
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.61663921
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59278891
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58586338
43EZH2_22144423_ChIP-Seq_EOC_Human1.57899678
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48720258
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48194144
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47915644
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43789002
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43535203
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41742450
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38618789
51FUS_26573619_Chip-Seq_HEK293_Human1.38529777
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.32223435
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31606151
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30132765
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29678976
56* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25505841
57ER_23166858_ChIP-Seq_MCF-7_Human1.24883877
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22856526
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22835218
60FOXP3_21729870_ChIP-Seq_TREG_Human1.22476725
61* HTT_18923047_ChIP-ChIP_STHdh_Human1.22194799
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21409135
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21333653
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20843241
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.20282970
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20135765
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18800835
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17861338
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.16228124
70P300_19829295_ChIP-Seq_ESCs_Human1.15504339
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13726916
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13091845
73* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13005288
74* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12430086
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12138345
76AR_21909140_ChIP-Seq_LNCAP_Human1.11838209
77KDM5A_27292631_Chip-Seq_BREAST_Human1.11736904
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09641721
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09565317
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09453667
81MYC_18940864_ChIP-ChIP_HL60_Human1.08913575
82TTF2_22483619_ChIP-Seq_HELA_Human1.08477153
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06312932
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.04733657
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04258279
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03837338
87JUN_21703547_ChIP-Seq_K562_Human1.03138491
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03029920
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01632822
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00721585
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00441466
92IGF1R_20145208_ChIP-Seq_DFB_Human0.99981728
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99762108
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99436870
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.99338151
96EWS_26573619_Chip-Seq_HEK293_Human0.98770260
97* XRN2_22483619_ChIP-Seq_HELA_Human0.98317238
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.98068995
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97978409
100* GABP_19822575_ChIP-Seq_HepG2_Human0.96633385
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94732951
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94191639
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93750575
104* NANOG_16153702_ChIP-ChIP_HESCs_Human0.93258566
105ZNF274_21170338_ChIP-Seq_K562_Hela0.91410416
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91200943
107ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90880087
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90605942
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90280920
110NANOG_19829295_ChIP-Seq_ESCs_Human0.89950335
111SOX2_19829295_ChIP-Seq_ESCs_Human0.89950335
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.89821546
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89696696
114* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88999845
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88731797
116* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88227606
117JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88009430
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87834139
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.87812676
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87647930
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.86982285
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86741595
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86680726
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85125726
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84092100
126RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83481405
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.83238457
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82412847
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82347505
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.81952753
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80872478
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80839114
133* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80525859
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80279099
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80208390
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79449062
137FOXP1_21924763_ChIP-Seq_HESCs_Human0.77962345
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76993034
139TP53_22573176_ChIP-Seq_HFKS_Human0.75046506
140ELF5_23300383_ChIP-Seq_T47D_Human0.70624314
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67584884
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67575169
143* TFEB_21752829_ChIP-Seq_HELA_Human0.66298025
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65754544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.08464470
2MP0003880_abnormal_central_pattern4.02855673
3MP0008058_abnormal_DNA_repair3.69265056
4MP0001905_abnormal_dopamine_level3.54481376
5MP0003693_abnormal_embryo_hatching3.41695627
6MP0004957_abnormal_blastocyst_morpholog3.14946427
7MP0006276_abnormal_autonomic_nervous3.10770189
8MP0010094_abnormal_chromosome_stability2.85871015
9MP0009379_abnormal_foot_pigmentation2.65393730
10MP0003111_abnormal_nucleus_morphology2.63418815
11MP0003806_abnormal_nucleotide_metabolis2.62339334
12MP0002736_abnormal_nociception_after2.60406597
13MP0003077_abnormal_cell_cycle2.44753724
14MP0004142_abnormal_muscle_tone2.32845847
15MP0005171_absent_coat_pigmentation2.24215527
16MP0001968_abnormal_touch/_nociception2.21758333
17MP0006036_abnormal_mitochondrial_physio2.19190422
18MP0003786_premature_aging2.16684508
19MP0008932_abnormal_embryonic_tissue2.14603819
20MP0003186_abnormal_redox_activity2.10317549
21MP0003195_calcinosis2.06374363
22MP0009745_abnormal_behavioral_response2.02096645
23MP0006035_abnormal_mitochondrial_morpho1.96053586
24MP0002735_abnormal_chemical_nociception1.94322467
25MP0002272_abnormal_nervous_system1.92086528
26MP0002876_abnormal_thyroid_physiology1.91002614
27MP0002064_seizures1.88447313
28MP0003136_yellow_coat_color1.87990072
29MP0001440_abnormal_grooming_behavior1.86066110
30MP0006072_abnormal_retinal_apoptosis1.84462822
31MP0008007_abnormal_cellular_replicative1.82837967
32MP0002837_dystrophic_cardiac_calcinosis1.81939768
33MP0000372_irregular_coat_pigmentation1.79201964
34MP0009697_abnormal_copulation1.77394536
35MP0002638_abnormal_pupillary_reflex1.77326331
36MP0002102_abnormal_ear_morphology1.75900432
37MP0009046_muscle_twitch1.75482125
38MP0000920_abnormal_myelination1.70325486
39MP0002734_abnormal_mechanical_nocicepti1.62036629
40MP0002822_catalepsy1.62015348
41MP0010030_abnormal_orbit_morphology1.59169725
42MP0008875_abnormal_xenobiotic_pharmacok1.58927323
43MP0003718_maternal_effect1.54073577
44MP0002572_abnormal_emotion/affect_behav1.51753750
45MP0001501_abnormal_sleep_pattern1.50958704
46MP0005451_abnormal_body_composition1.50873021
47MP0005386_behavior/neurological_phenoty1.49753843
48MP0004924_abnormal_behavior1.49753843
49MP0001970_abnormal_pain_threshold1.48193146
50MP0008260_abnormal_autophagy1.47318683
51MP0001764_abnormal_homeostasis1.46009824
52MP0002139_abnormal_hepatobiliary_system1.44912681
53MP0002733_abnormal_thermal_nociception1.41660424
54MP0002067_abnormal_sensory_capabilities1.40779951
55MP0001486_abnormal_startle_reflex1.40605288
56MP0004742_abnormal_vestibular_system1.38777013
57MP0001188_hyperpigmentation1.36941499
58MP0010386_abnormal_urinary_bladder1.35660054
59MP0001984_abnormal_olfaction1.32336781
60MP0003941_abnormal_skin_development1.30419093
61MP0003635_abnormal_synaptic_transmissio1.29419234
62MP0001727_abnormal_embryo_implantation1.27420335
63MP0005332_abnormal_amino_acid1.26310948
64MP0005409_darkened_coat_color1.25932829
65MP0005408_hypopigmentation1.25290555
66MP0005379_endocrine/exocrine_gland_phen1.20584650
67MP0002160_abnormal_reproductive_system1.20481232
68MP0004133_heterotaxia1.20276744
69MP0005085_abnormal_gallbladder_physiolo1.20214601
70MP0004270_analgesia1.20204666
71MP0001293_anophthalmia1.19718166
72MP0000358_abnormal_cell_content/1.19510379
73MP0003315_abnormal_perineum_morphology1.17861455
74MP0003011_delayed_dark_adaptation1.17842178
75MP0002063_abnormal_learning/memory/cond1.17165311
76MP0008877_abnormal_DNA_methylation1.16686905
77MP0008872_abnormal_physiological_respon1.13884976
78MP0004381_abnormal_hair_follicle1.11053155
79MP0005253_abnormal_eye_physiology1.10928465
80MP0006292_abnormal_olfactory_placode1.10321354
81MP0003123_paternal_imprinting1.08721172
82MP0003690_abnormal_glial_cell1.08378566
83MP0005075_abnormal_melanosome_morpholog1.08187396
84MP0002090_abnormal_vision1.06715741
85MP0002163_abnormal_gland_morphology1.06296164
86MP0002234_abnormal_pharynx_morphology1.05977836
87MP0004147_increased_porphyrin_level1.02644051
88MP0002210_abnormal_sex_determination1.02265290
89MP0008995_early_reproductive_senescence1.00564635
90MP0000749_muscle_degeneration0.99149954
91MP0005535_abnormal_body_temperature0.98524099
92MP0001986_abnormal_taste_sensitivity0.98354618
93MP0005551_abnormal_eye_electrophysiolog0.98136893
94MP0003567_abnormal_fetal_cardiomyocyte0.98128574
95MP0005423_abnormal_somatic_nervous0.96943973
96MP0005360_urolithiasis0.96705481
97MP0004043_abnormal_pH_regulation0.96605144
98MP0002095_abnormal_skin_pigmentation0.94941506
99MP0001963_abnormal_hearing_physiology0.94428422
100MP0002148_abnormal_hypersensitivity_rea0.93957389
101MP0005389_reproductive_system_phenotype0.93491512
102MP0002938_white_spotting0.93277916
103MP0002229_neurodegeneration0.92662551
104MP0005084_abnormal_gallbladder_morpholo0.92026879
105MP0001929_abnormal_gametogenesis0.91974886
106MP0000647_abnormal_sebaceous_gland0.90949663
107MP0005636_abnormal_mineral_homeostasis0.90898791
108MP0000778_abnormal_nervous_system0.90507393
109MP0002132_abnormal_respiratory_system0.89077969
110MP0008789_abnormal_olfactory_epithelium0.88466481
111MP0003724_increased_susceptibility_to0.87651040
112MP0000026_abnormal_inner_ear0.87442920
113MP0005376_homeostasis/metabolism_phenot0.85062970
114MP0005083_abnormal_biliary_tract0.83092784
115MP0003121_genomic_imprinting0.82525500
116MP0002557_abnormal_social/conspecific_i0.82226336
117MP0002066_abnormal_motor_capabilities/c0.82117913
118MP0000653_abnormal_sex_gland0.81710810
119MP0001485_abnormal_pinna_reflex0.81490106
120MP0003137_abnormal_impulse_conducting0.81195268
121MP0002277_abnormal_respiratory_mucosa0.81193449
122MP0001919_abnormal_reproductive_system0.81123945
123MP0003937_abnormal_limbs/digits/tail_de0.80275148
124MP0001145_abnormal_male_reproductive0.80264254
125MP0000566_synostosis0.80070528
126MP0002751_abnormal_autonomic_nervous0.79455222
127MP0005645_abnormal_hypothalamus_physiol0.78175197
128MP0005410_abnormal_fertilization0.77748934
129MP0005584_abnormal_enzyme/coenzyme_acti0.77449814
130MP0006082_CNS_inflammation0.76808462
131MP0003646_muscle_fatigue0.76251879
132MP0000538_abnormal_urinary_bladder0.76238525
133MP0009785_altered_susceptibility_to0.76178440
134MP0003950_abnormal_plasma_membrane0.75989585
135MP0003329_amyloid_beta_deposits0.75654555
136MP0005646_abnormal_pituitary_gland0.75163666
137MP0002184_abnormal_innervation0.75110268
138MP0000049_abnormal_middle_ear0.75029529
139MP0004215_abnormal_myocardial_fiber0.74941661
140MP0001542_abnormal_bone_strength0.74856025
141MP0001697_abnormal_embryo_size0.71371938
142MP0004019_abnormal_vitamin_homeostasis0.70758219
143MP0000313_abnormal_cell_death0.68922065
144MP0000350_abnormal_cell_proliferation0.67546011
145MP0003283_abnormal_digestive_organ0.65456568
146MP0005266_abnormal_metabolism0.63313606
147MP0001119_abnormal_female_reproductive0.63115660
148MP0001324_abnormal_eye_pigmentation0.62706651
149MP0001661_extended_life_span0.61165433
150MP0000631_abnormal_neuroendocrine_gland0.60946291

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.91280140
2Abnormal mitochondria in muscle tissue (HP:0008316)6.30931873
3Mitochondrial inheritance (HP:0001427)6.10461709
4Acute encephalopathy (HP:0006846)5.79734752
5Progressive macrocephaly (HP:0004481)5.77897942
6Hepatocellular necrosis (HP:0001404)5.22991187
7Increased CSF lactate (HP:0002490)5.22477051
8Increased hepatocellular lipid droplets (HP:0006565)4.79200863
9Hepatic necrosis (HP:0002605)4.69774689
10Renal Fanconi syndrome (HP:0001994)4.60808571
113-Methylglutaconic aciduria (HP:0003535)4.40379297
12Cerebral edema (HP:0002181)4.34438744
13Lipid accumulation in hepatocytes (HP:0006561)4.30036384
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.22646657
15Abnormality of glycolysis (HP:0004366)4.08891738
16Increased serum pyruvate (HP:0003542)4.08891738
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.95043173
18Increased intramyocellular lipid droplets (HP:0012240)3.84450538
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.73233083
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.73233083
21Optic disc pallor (HP:0000543)3.68962209
22Leukodystrophy (HP:0002415)3.63039065
23Lactic acidosis (HP:0003128)3.57551992
24Respiratory failure (HP:0002878)3.57415311
25Exercise intolerance (HP:0003546)3.53932916
26Parakeratosis (HP:0001036)3.41408122
27Increased serum lactate (HP:0002151)3.38920637
28Increased muscle lipid content (HP:0009058)3.25184386
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24135433
30Reticulocytopenia (HP:0001896)3.07188473
31Exertional dyspnea (HP:0002875)3.05393542
32Abnormality of renal resorption (HP:0011038)3.03608236
33Hypothermia (HP:0002045)2.76159969
34Respiratory difficulties (HP:0002880)2.71774955
35Neuroendocrine neoplasm (HP:0100634)2.60155840
36CNS demyelination (HP:0007305)2.59477764
37Lethargy (HP:0001254)2.59322369
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49695767
39Glycosuria (HP:0003076)2.49274998
40Abnormality of urine glucose concentration (HP:0011016)2.49274998
41Aplastic anemia (HP:0001915)2.41965555
42Cerebral hypomyelination (HP:0006808)2.39908923
43Congenital ichthyosiform erythroderma (HP:0007431)2.36813285
44X-linked dominant inheritance (HP:0001423)2.34876548
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33802225
46Pheochromocytoma (HP:0002666)2.33757379
47Congenital, generalized hypertrichosis (HP:0004540)2.32297358
48Colon cancer (HP:0003003)2.32213742
49Generalized aminoaciduria (HP:0002909)2.31003531
50Hyperphosphaturia (HP:0003109)2.27020952
51Medial flaring of the eyebrow (HP:0010747)2.25728728
52Abnormality of cells of the erythroid lineage (HP:0012130)2.24574709
53Abnormality of the anterior horn cell (HP:0006802)2.22142044
54Degeneration of anterior horn cells (HP:0002398)2.22142044
55Amniotic constriction ring (HP:0009775)2.19592442
56Abnormality of placental membranes (HP:0011409)2.19592442
57Emotional lability (HP:0000712)2.16185607
58Reduced antithrombin III activity (HP:0001976)2.15954860
59Limb dystonia (HP:0002451)2.15495878
60Oral leukoplakia (HP:0002745)2.15039665
61Methylmalonic acidemia (HP:0002912)2.14807512
62Abnormal protein glycosylation (HP:0012346)2.14777710
63Abnormal glycosylation (HP:0012345)2.14777710
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14777710
65Abnormal protein N-linked glycosylation (HP:0012347)2.14777710
66Delusions (HP:0000746)2.06273276
67Microvesicular hepatic steatosis (HP:0001414)2.05362502
68Abnormal pupillary function (HP:0007686)2.05253013
69Myokymia (HP:0002411)2.03273735
70Congenital primary aphakia (HP:0007707)2.02636588
71Abnormal number of erythroid precursors (HP:0012131)2.02634515
72Irregular epiphyses (HP:0010582)2.02584348
73Gait imbalance (HP:0002141)2.02513718
74Pancreatic cysts (HP:0001737)2.02080493
75Meckel diverticulum (HP:0002245)1.99743534
76Abnormality of the labia minora (HP:0012880)1.96593911
77Renal tubular dysfunction (HP:0000124)1.96324111
78Sparse eyelashes (HP:0000653)1.95190819
79Pancreatic fibrosis (HP:0100732)1.94330075
80Abnormality of methionine metabolism (HP:0010901)1.94249233
81Methylmalonic aciduria (HP:0012120)1.94155164
82Abnormality of the ileum (HP:0001549)1.94139315
83Nephrogenic diabetes insipidus (HP:0009806)1.93414457
84Focal motor seizures (HP:0011153)1.92626047
85Abnormality of midbrain morphology (HP:0002418)1.91520239
86Molar tooth sign on MRI (HP:0002419)1.91520239
87Hyperglycinemia (HP:0002154)1.89932344
88Abnormality of serum amino acid levels (HP:0003112)1.88520428
89Pancytopenia (HP:0001876)1.87430982
90Macrocytic anemia (HP:0001972)1.86619968
91Hyperventilation (HP:0002883)1.86600589
92Abnormal urine phosphate concentration (HP:0012599)1.85812075
93Retinal dysplasia (HP:0007973)1.83783006
94Cerebral hemorrhage (HP:0001342)1.83235416
95Testicular atrophy (HP:0000029)1.81698084
96Vaginal atresia (HP:0000148)1.80513593
97True hermaphroditism (HP:0010459)1.79781845
98Spastic paraparesis (HP:0002313)1.79345807
99Blindness (HP:0000618)1.79296914
100Progressive external ophthalmoplegia (HP:0000590)1.77241652
101Vomiting (HP:0002013)1.77077784
102Absent thumb (HP:0009777)1.76750552
103Gliosis (HP:0002171)1.76098375
104Genital tract atresia (HP:0001827)1.74651713
105Neoplasm of the adrenal gland (HP:0100631)1.74457354
106Rough bone trabeculation (HP:0100670)1.73940203
107Pallor (HP:0000980)1.73895656
108Poor suck (HP:0002033)1.73189670
109Multiple enchondromatosis (HP:0005701)1.72486113
110Sensory axonal neuropathy (HP:0003390)1.71803273
111Abnormality of the preputium (HP:0100587)1.71665779
112Abnormal hair whorl (HP:0010721)1.71138735
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.70044929
114Microretrognathia (HP:0000308)1.69538143
115Dicarboxylic aciduria (HP:0003215)1.69525294
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69525294
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68658256
118Sclerocornea (HP:0000647)1.67301351
119Prolonged neonatal jaundice (HP:0006579)1.66739823
120Opisthotonus (HP:0002179)1.62891569
121Hypokinesia (HP:0002375)1.62822105
122Hypoplasia of the pons (HP:0012110)1.59918373
123Autoamputation (HP:0001218)1.58583337
124Abnormality of the pons (HP:0007361)1.57100540
125Esotropia (HP:0000565)1.56875326
126Abnormality of alanine metabolism (HP:0010916)1.56164690
127Hyperalaninemia (HP:0003348)1.56164690
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56164690
129Hepatosplenomegaly (HP:0001433)1.51494495
130Abnormality of the axillary hair (HP:0100134)1.51487800
131Abnormality of secondary sexual hair (HP:0009888)1.51487800
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.50904890
133CNS hypomyelination (HP:0003429)1.49617739
134Patchy hypopigmentation of hair (HP:0011365)1.46394001
135Hypoplastic left heart (HP:0004383)1.45102712
136Type I transferrin isoform profile (HP:0003642)1.42968127
137Brushfield spots (HP:0001088)1.42392563
138Poor coordination (HP:0002370)1.40596417
139Aplasia/hypoplasia of the uterus (HP:0008684)1.38608006
140Hypobetalipoproteinemia (HP:0003563)1.37276812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.92822247
2STK163.46918023
3MAP3K123.14971383
4CASK3.02590894
5BUB12.87662107
6PBK2.60243388
7ARAF2.57953585
8NME12.38028982
9STK392.32888907
10CDC72.24847978
11MST42.20005126
12NEK12.18660376
13BMPR1B2.17801601
14NME22.12441887
15BCR2.10423369
16MAP2K72.02254239
17OXSR11.97852039
18GRK71.96161829
19PNCK1.82421228
20ADRBK21.76134774
21TAF11.70645370
22EIF2AK11.69229992
23WNK31.68637407
24NUAK11.66949040
25TNIK1.63723977
26EIF2AK31.62274835
27TTK1.58827426
28TRIM281.55647974
29MAPKAPK51.51024260
30VRK11.49381955
31MYLK1.45872505
32CDK191.41813058
33MAP4K21.41355220
34PIM21.39019105
35GRK51.37166707
36SRPK11.36482037
37BMPR21.36435961
38PLK11.31532172
39BRAF1.27809550
40MUSK1.26789753
41LIMK11.23194968
42IRAK31.14868581
43PLK21.14738425
44BRSK11.13129481
45ABL21.11335901
46TESK11.08613202
47WNK41.05734791
48CAMK2B1.04572801
49CSNK1G31.02550378
50BRSK21.02533702
51AURKB1.01125321
52DYRK20.99751622
53BCKDK0.98617910
54TESK20.98422693
55WEE10.96200818
56IRAK40.93221408
57EPHA40.93139691
58TSSK60.91909064
59ZAK0.91812417
60OBSCN0.89955895
61CAMK2D0.88351134
62PLK40.87947249
63INSRR0.85756830
64CHEK20.84019300
65MAP3K40.83736271
66AKT30.83652726
67SIK30.82910823
68RIPK40.82111723
69CAMK2A0.81612860
70CAMK2G0.81216628
71PINK10.80287183
72DAPK10.79793223
73NEK60.79338002
74MARK10.78776457
75MAPK130.76978139
76IRAK20.76190138
77PKN10.74596106
78UHMK10.72800542
79CSNK1A1L0.72662191
80TLK10.71592379
81ATR0.71454322
82EIF2AK20.70139818
83ACVR1B0.68107191
84PAK40.67859405
85MAP2K40.67407716
86MKNK10.67263730
87YES10.66887557
88ILK0.66187227
89STK40.66042903
90RPS6KA50.65959343
91DAPK30.65797310
92DYRK30.65722969
93ADRBK10.64293385
94PRKCI0.61322005
95IRAK10.60631562
96PRKCE0.58889057
97MINK10.57117069
98PHKG20.56894587
99PHKG10.56894587
100CDK80.56838331
101PRKCG0.56775719
102CSNK1G10.54516272
103AURKA0.52951412
104FGR0.52830762
105PLK30.52174483
106CSNK2A10.51857927
107ERBB30.51779440
108MKNK20.47182788
109TXK0.47105044
110MAP3K110.46923430
111KDR0.46840952
112PRKACA0.45625569
113MAP3K140.43790728
114CDK70.43604403
115CSNK1G20.43141907
116NTRK30.41622336
117PDK20.41129464
118ROCK20.39284633
119PAK10.38515555
120CCNB10.38474698
121CSNK1E0.38034866
122CHEK10.37720002
123CSNK2A20.37517797
124CDK140.36138617
125PRPF4B0.35774263
126SCYL20.35744593
127ATM0.35006089
128RPS6KA40.34642637
129PRKCQ0.34545088
130MAPK40.34066097
131SGK2230.33979875
132SGK4940.33979875
133NEK20.33800569
134CDK180.33733494
135GRK10.33579931
136ERBB40.31881322
137CSNK1A10.31835890
138AKT20.31658983
139FRK0.31139421

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.80861695
2Parkinsons disease_Homo sapiens_hsa050124.81775099
3Proteasome_Homo sapiens_hsa030503.79543364
4Alzheimers disease_Homo sapiens_hsa050103.60390890
5Huntingtons disease_Homo sapiens_hsa050163.33827775
6* Ribosome_Homo sapiens_hsa030103.07026518
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.02802001
8RNA polymerase_Homo sapiens_hsa030202.46182881
9Protein export_Homo sapiens_hsa030602.43811407
10Fatty acid elongation_Homo sapiens_hsa000622.43237813
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16636520
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15108517
13Collecting duct acid secretion_Homo sapiens_hsa049661.98374558
14Cardiac muscle contraction_Homo sapiens_hsa042601.93014548
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92005953
16Base excision repair_Homo sapiens_hsa034101.81089399
17Steroid biosynthesis_Homo sapiens_hsa001001.76737660
18Sulfur metabolism_Homo sapiens_hsa009201.70654379
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45171285
20One carbon pool by folate_Homo sapiens_hsa006701.43141752
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41453409
22Pyrimidine metabolism_Homo sapiens_hsa002401.41005814
23RNA transport_Homo sapiens_hsa030131.28198811
24Folate biosynthesis_Homo sapiens_hsa007901.27732321
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24116385
26Pyruvate metabolism_Homo sapiens_hsa006201.18008485
27Histidine metabolism_Homo sapiens_hsa003401.14504146
28Vibrio cholerae infection_Homo sapiens_hsa051101.11862299
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10828358
30Peroxisome_Homo sapiens_hsa041461.10678039
31Tyrosine metabolism_Homo sapiens_hsa003501.09647655
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07933945
33Rheumatoid arthritis_Homo sapiens_hsa053231.07591266
34Phenylalanine metabolism_Homo sapiens_hsa003601.07068500
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07036857
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05393707
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04151199
38Glutathione metabolism_Homo sapiens_hsa004801.03362088
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03163895
40Butanoate metabolism_Homo sapiens_hsa006501.02723898
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02451355
42Propanoate metabolism_Homo sapiens_hsa006401.01494646
43Metabolic pathways_Homo sapiens_hsa011001.00882149
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98706217
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98057628
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97684544
47Chemical carcinogenesis_Homo sapiens_hsa052040.94529379
48Nicotine addiction_Homo sapiens_hsa050330.90872348
49Biosynthesis of amino acids_Homo sapiens_hsa012300.84303780
50Cell cycle_Homo sapiens_hsa041100.82347341
51Synaptic vesicle cycle_Homo sapiens_hsa047210.79743582
52Arginine and proline metabolism_Homo sapiens_hsa003300.79734870
53Ether lipid metabolism_Homo sapiens_hsa005650.78814720
54Purine metabolism_Homo sapiens_hsa002300.77771437
55Vitamin B6 metabolism_Homo sapiens_hsa007500.77195338
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76212428
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74535676
58Arachidonic acid metabolism_Homo sapiens_hsa005900.74206734
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.69924986
60Homologous recombination_Homo sapiens_hsa034400.69468650
61Regulation of autophagy_Homo sapiens_hsa041400.69041919
62Sulfur relay system_Homo sapiens_hsa041220.68561200
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68149635
64Graft-versus-host disease_Homo sapiens_hsa053320.67428248
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66466787
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.65233517
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.62655025
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62209358
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.61618881
70Nucleotide excision repair_Homo sapiens_hsa034200.59635562
71beta-Alanine metabolism_Homo sapiens_hsa004100.58971027
72Serotonergic synapse_Homo sapiens_hsa047260.58583952
73Basal transcription factors_Homo sapiens_hsa030220.57625010
74Carbon metabolism_Homo sapiens_hsa012000.57043025
75Selenocompound metabolism_Homo sapiens_hsa004500.55387701
76Linoleic acid metabolism_Homo sapiens_hsa005910.55186574
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54813065
78Spliceosome_Homo sapiens_hsa030400.53747031
79Retinol metabolism_Homo sapiens_hsa008300.52449861
80Sphingolipid metabolism_Homo sapiens_hsa006000.50071949
81Phagosome_Homo sapiens_hsa041450.49962142
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49814005
83Phototransduction_Homo sapiens_hsa047440.48728215
84Fatty acid metabolism_Homo sapiens_hsa012120.47768298
85Tryptophan metabolism_Homo sapiens_hsa003800.46619097
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46254155
87N-Glycan biosynthesis_Homo sapiens_hsa005100.46163430
88Nitrogen metabolism_Homo sapiens_hsa009100.44613145
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.44079717
90p53 signaling pathway_Homo sapiens_hsa041150.43301762
91Autoimmune thyroid disease_Homo sapiens_hsa053200.41784711
92Taste transduction_Homo sapiens_hsa047420.40234477
93Allograft rejection_Homo sapiens_hsa053300.38259312
94DNA replication_Homo sapiens_hsa030300.36497138
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36251368
96Fatty acid degradation_Homo sapiens_hsa000710.35917124
97Oocyte meiosis_Homo sapiens_hsa041140.35729506
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35441733
99Fructose and mannose metabolism_Homo sapiens_hsa000510.32757644
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32553819
101GABAergic synapse_Homo sapiens_hsa047270.31991637
102Arginine biosynthesis_Homo sapiens_hsa002200.29949488
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29482263
104Pentose phosphate pathway_Homo sapiens_hsa000300.29302848
105Systemic lupus erythematosus_Homo sapiens_hsa053220.27389903
106Asthma_Homo sapiens_hsa053100.27355892
107Epstein-Barr virus infection_Homo sapiens_hsa051690.27019381
108Mismatch repair_Homo sapiens_hsa034300.27002993
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26740714
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26570345
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26508777
112RNA degradation_Homo sapiens_hsa030180.24859163
113Type I diabetes mellitus_Homo sapiens_hsa049400.24381976
114Vitamin digestion and absorption_Homo sapiens_hsa049770.22535845
115Fat digestion and absorption_Homo sapiens_hsa049750.21947423
116Mineral absorption_Homo sapiens_hsa049780.21285434
117Non-homologous end-joining_Homo sapiens_hsa034500.21248221
118African trypanosomiasis_Homo sapiens_hsa051430.20414801
119mRNA surveillance pathway_Homo sapiens_hsa030150.19932376
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17027113
121Galactose metabolism_Homo sapiens_hsa000520.15774774
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13989864
123Morphine addiction_Homo sapiens_hsa050320.11721824
124Fanconi anemia pathway_Homo sapiens_hsa034600.11513680

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