ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	7.48099366
2	sequestering of actin monomers (GO:0042989)	7.39403905
3	sterol catabolic process (GO:0016127)	7.29975427
4	cholesterol catabolic process (GO:0006707)	7.29975427
5	fusion of sperm to egg plasma membrane (GO:0007342)	7.10519366
6	sperm capacitation (GO:0048240)	6.36095301
7	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	6.31630807
8	multicellular organism reproduction (GO:0032504)	6.07379667
9	protein-chromophore linkage (GO:0018298)	5.91802697
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.46364841
11	plasma membrane fusion (GO:0045026)	5.43522769
12	positive regulation of gastrulation (GO:2000543)	5.40970171
13	membrane depolarization during action potential (GO:0086010)	5.25985898
14	regulation of cell communication by electrical coupling (GO:0010649)	5.22916301
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.22388139
16	regulation of acrosome reaction (GO:0060046)	5.20154761
17	serotonin metabolic process (GO:0042428)	5.19685359
18	positive regulation of sodium ion transmembrane transport (GO:1902307)	5.13895954
19	neuronal action potential (GO:0019228)	4.83984821
20	calcium ion import (GO:0070509)	4.79896076
21	ATP synthesis coupled proton transport (GO:0015986)	4.75315293
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.75315293
23	primary amino compound metabolic process (GO:1901160)	4.69665799
24	regulation of action potential (GO:0098900)	4.53825953
25	positive regulation of membrane potential (GO:0045838)	4.30376736
26	sleep (GO:0030431)	4.18003245
27	reproduction (GO:0000003)	3.89657662
28	steroid catabolic process (GO:0006706)	3.82272671
29	negative regulation of telomere maintenance (GO:0032205)	3.70682811
30	histone H4-K12 acetylation (GO:0043983)	3.58848952
31	response to pheromone (GO:0019236)	3.56379201
32	bile acid biosynthetic process (GO:0006699)	3.55107843
33	rhodopsin mediated signaling pathway (GO:0016056)	3.54862629
34	protein targeting to plasma membrane (GO:0072661)	3.53120284
35	sperm-egg recognition (GO:0035036)	3.49580989
36	primitive streak formation (GO:0090009)	3.45516258
37	indole-containing compound metabolic process (GO:0042430)	3.38462781
38	tachykinin receptor signaling pathway (GO:0007217)	3.33803971
39	ovulation cycle (GO:0042698)	3.31488459
40	C21-steroid hormone metabolic process (GO:0008207)	3.27383646
41	skeletal muscle tissue regeneration (GO:0043403)	3.26322653
42	sperm motility (GO:0030317)	3.24516038
43	axonemal dynein complex assembly (GO:0070286)	3.24467150
44	positive regulation of embryonic development (GO:0040019)	3.23280665
45	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.20027864
46	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	3.18955451
47	membrane assembly (GO:0071709)	3.16009099
48	positive regulation of T cell differentiation in thymus (GO:0033089)	3.10241272
49	regulation of gonadotropin secretion (GO:0032276)	3.10039095
50	dorsal/ventral neural tube patterning (GO:0021904)	3.07434411
51	behavioral response to ethanol (GO:0048149)	3.06701037
52	cell-cell recognition (GO:0009988)	3.03981878
53	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.00430112
54	cell proliferation involved in metanephros development (GO:0072203)	3.00002196
55	positive regulation of protein complex disassembly (GO:0043243)	2.98299970
56	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.94746778
57	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.89280975
58	behavioral response to nicotine (GO:0035095)	2.86967963
59	cilium or flagellum-dependent cell motility (GO:0001539)	2.86359059
60	regulation of homotypic cell-cell adhesion (GO:0034110)	2.84816308
61	kynurenine metabolic process (GO:0070189)	2.84080428
62	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83841969
63	C4-dicarboxylate transport (GO:0015740)	2.81913590
64	ATP biosynthetic process (GO:0006754)	2.81638297
65	regulation of protein targeting to membrane (GO:0090313)	2.80989943
66	androgen metabolic process (GO:0008209)	2.80245177
67	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.79291353
68	circadian sleep/wake cycle process (GO:0022410)	2.77879672
69	auditory behavior (GO:0031223)	2.77456939
70	positive regulation of protein targeting to membrane (GO:0090314)	2.74624376
71	neuron cell-cell adhesion (GO:0007158)	2.74265119
72	righting reflex (GO:0060013)	2.74188838
73	response to gravity (GO:0009629)	2.73168962
74	lung lobe morphogenesis (GO:0060463)	2.68993705
75	positive regulation of sodium ion transport (GO:0010765)	2.67276951
76	hydrogen ion transmembrane transport (GO:1902600)	2.66556033
77	spinal cord association neuron differentiation (GO:0021527)	2.64083258
78	positive regulation of protein depolymerization (GO:1901881)	2.63442342
79	positive regulation of vascular permeability (GO:0043117)	2.63009706
80	growth hormone secretion (GO:0030252)	2.59166833
81	exploration behavior (GO:0035640)	2.58097452
82	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.57139823
83	regulation of sodium ion transmembrane transporter activity (GO:2000649)	2.56867159
84	negative regulation of kidney development (GO:0090185)	2.56211436
85	response to dietary excess (GO:0002021)	2.56123062
86	somite rostral/caudal axis specification (GO:0032525)	2.55729779
87	action potential (GO:0001508)	2.55553058
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54338184
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54338184
90	neurofilament cytoskeleton organization (GO:0060052)	2.54276796
91	cAMP catabolic process (GO:0006198)	2.53911231
92	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.51285449
93	thalamus development (GO:0021794)	2.51259772
94	reflex (GO:0060004)	2.50556226
95	protein polyglutamylation (GO:0018095)	2.49089179
96	neuroblast proliferation (GO:0007405)	2.48527325
97	DNA methylation involved in gamete generation (GO:0043046)	2.47664585
98	membrane depolarization (GO:0051899)	2.47111700
99	positive regulation of neurotransmitter secretion (GO:0001956)	2.46409091
100	neurotransmitter biosynthetic process (GO:0042136)	2.45320204

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.78984373
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.99017936
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.26022704
4	VDR_22108803_ChIP-Seq_LS180_Human	3.59924869
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.00153741
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.77737607
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70336911
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.57823827
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53201058
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.28099465
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26520755
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.25611636
13	EGR1_19032775_ChIP-ChIP_M12_Human	2.16095179
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.15461480
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.06905378
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.05459632
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87025808
18	RNF2_27304074_Chip-Seq_NSC_Mouse	1.85533343
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.85172992
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.84573380
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84150852
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.79397131
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.77845793
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.75647196
25	P300_19829295_ChIP-Seq_ESCs_Human	1.70071969
26	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.67787702
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60433653
28	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.59260958
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.56961015
30	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.55252722
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49100845
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47084739
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.46942016
34	FUS_26573619_Chip-Seq_HEK293_Human	1.42770021
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41586417
36	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.40636137
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39229683
38	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.37229373
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37102450
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36969422
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36525903
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35616421
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35105419
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33776114
45	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.29804809
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29184820
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28159851
48	AR_20517297_ChIP-Seq_VCAP_Human	1.27458436
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.25955257
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25840089
51	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.25337315
52	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25014607
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24890030
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22476281
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21851677
56	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.20196528
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18364009
58	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16251774
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.15875589
60	KDM2B_26808549_Chip-Seq_REH_Human	1.14136260
61	ERA_21632823_ChIP-Seq_H3396_Human	1.14105698
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12930221
63	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.12637633
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.08914821
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08588811
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07918379
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.06895288
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06399382
69	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05579229
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05110263
71	CTCF_27219007_Chip-Seq_Bcells_Human	1.03145995
72	TCF4_23295773_ChIP-Seq_U87_Human	1.02804803
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00342830
74	STAT3_23295773_ChIP-Seq_U87_Human	1.00306514
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00157350
76	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99881507
77	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99881507
78	AR_25329375_ChIP-Seq_VCAP_Human	0.98287470
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97329978
80	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.97004313
81	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.95717779
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93152525
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93077073
84	TP53_22573176_ChIP-Seq_HFKS_Human	0.89262189
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.89046580
86	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89036461
87	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.88273033
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88189543
89	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.87095282
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.87046229
91	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.86461890
92	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.85350845
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85097794
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.83961804
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.83848224
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82539613
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.81906122
98	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.81554240
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.81212503
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.81212503

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	6.42222351
2	MP0003283_abnormal_digestive_organ	6.38275129
3	MP0002822_catalepsy	4.11830341
4	MP0009379_abnormal_foot_pigmentation	4.01140572
5	MP0004043_abnormal_pH_regulation	2.99847308
6	MP0004133_heterotaxia	2.63955542
7	MP0000569_abnormal_digit_pigmentation	2.53665162
8	MP0004142_abnormal_muscle_tone	2.29833798
9	MP0008995_early_reproductive_senescence	2.27069490
10	MP0003646_muscle_fatigue	2.26146684
11	MP0001986_abnormal_taste_sensitivity	2.24981349
12	MP0008877_abnormal_DNA_methylation	2.04780098
13	MP0000372_irregular_coat_pigmentation	2.00498684
14	MP0001764_abnormal_homeostasis	1.97678303
15	MP0005379_endocrine/exocrine_gland_phen	1.96987174
16	MP0002102_abnormal_ear_morphology	1.96440935
17	MP0004859_abnormal_synaptic_plasticity	1.93931179
18	MP0001968_abnormal_touch/_nociception	1.93812398
19	MP0002064_seizures	1.88854767
20	MP0001905_abnormal_dopamine_level	1.84201782
21	MP0002736_abnormal_nociception_after	1.79088418
22	MP0009745_abnormal_behavioral_response	1.75325147
23	MP0004885_abnormal_endolymph	1.67894111
24	MP0003315_abnormal_perineum_morphology	1.66713191
25	MP0003195_calcinosis	1.63246549
26	MP0005253_abnormal_eye_physiology	1.59646135
27	MP0002735_abnormal_chemical_nociception	1.57628753
28	MP0008961_abnormal_basal_metabolism	1.50001551
29	MP0002234_abnormal_pharynx_morphology	1.45063465
30	MP0000566_synostosis	1.44175464
31	MP0002653_abnormal_ependyma_morphology	1.43677677
32	MP0001501_abnormal_sleep_pattern	1.43290241
33	MP0001502_abnormal_circadian_rhythm	1.39256456
34	MP0004510_myositis	1.37834518
35	MP0000383_abnormal_hair_follicle	1.36629404
36	MP0004019_abnormal_vitamin_homeostasis	1.33920111
37	MP0003635_abnormal_synaptic_transmissio	1.30346247
38	MP0004145_abnormal_muscle_electrophysio	1.28336566
39	MP0003011_delayed_dark_adaptation	1.26363951
40	MP0003119_abnormal_digestive_system	1.24296498
41	MP0002572_abnormal_emotion/affect_behav	1.22442863
42	MP0004147_increased_porphyrin_level	1.19557676
43	MP0000778_abnormal_nervous_system	1.18801121
44	MP0002837_dystrophic_cardiac_calcinosis	1.18791285
45	MP0002168_other_aberrant_phenotype	1.18748010
46	MP0002909_abnormal_adrenal_gland	1.18484078
47	MP0003136_yellow_coat_color	1.18452322
48	MP0003950_abnormal_plasma_membrane	1.13156265
49	MP0002272_abnormal_nervous_system	1.12468895
50	MP0005551_abnormal_eye_electrophysiolog	1.11231259
51	MP0003191_abnormal_cellular_cholesterol	1.11225078
52	MP0002938_white_spotting	1.10739142
53	MP0008057_abnormal_DNA_replication	1.08681871
54	MP0005187_abnormal_penis_morphology	1.07148349
55	MP0003938_abnormal_ear_development	1.05622483
56	MP0000750_abnormal_muscle_regeneration	1.05257110
57	MP0002277_abnormal_respiratory_mucosa	1.03938279
58	MP0005646_abnormal_pituitary_gland	0.99897882
59	MP0001873_stomach_inflammation	0.99579885
60	MP0002734_abnormal_mechanical_nocicepti	0.99441165
61	MP0000955_abnormal_spinal_cord	0.99275190
62	MP0009053_abnormal_anal_canal	0.97152085
63	MP0002067_abnormal_sensory_capabilities	0.96633215
64	MP0005365_abnormal_bile_salt	0.95513143
65	MP0005423_abnormal_somatic_nervous	0.92098664
66	MP0003787_abnormal_imprinting	0.91691170
67	MP0002733_abnormal_thermal_nociception	0.88047157
68	MP0009046_muscle_twitch	0.87641843
69	MP0002557_abnormal_social/conspecific_i	0.86762721
70	MP0002928_abnormal_bile_duct	0.86113581
71	MP0005395_other_phenotype	0.85853113
72	MP0003137_abnormal_impulse_conducting	0.85771795
73	MP0004130_abnormal_muscle_cell	0.84489289
74	MP0002063_abnormal_learning/memory/cond	0.83442084
75	MP0005360_urolithiasis	0.83286985
76	MP0000026_abnormal_inner_ear	0.82414967
77	MP0001188_hyperpigmentation	0.81729569
78	MP0001348_abnormal_lacrimal_gland	0.81595226
79	MP0005195_abnormal_posterior_eye	0.80182469
80	MP0002184_abnormal_innervation	0.77087342
81	MP0002095_abnormal_skin_pigmentation	0.76031676
82	MP0002882_abnormal_neuron_morphology	0.74998653
83	MP0005377_hearing/vestibular/ear_phenot	0.74345028
84	MP0003878_abnormal_ear_physiology	0.74345028
85	MP0002752_abnormal_somatic_nervous	0.74243446
86	MP0005084_abnormal_gallbladder_morpholo	0.72940320
87	MP0001486_abnormal_startle_reflex	0.72100379
88	MP0001970_abnormal_pain_threshold	0.71062980
89	MP0010678_abnormal_skin_adnexa	0.68874058
90	MP0002066_abnormal_motor_capabilities/c	0.67625391
91	MP0003718_maternal_effect	0.66480432
92	MP0004270_analgesia	0.63936411
93	MP0001293_anophthalmia	0.62801146
94	MP0003806_abnormal_nucleotide_metabolis	0.62115652
95	MP0005391_vision/eye_phenotype	0.61725232
96	MP0009643_abnormal_urine_homeostasis	0.61246553
97	MP0000534_abnormal_ureter_morphology	0.60403921
98	MP0000631_abnormal_neuroendocrine_gland	0.60252586
99	MP0001324_abnormal_eye_pigmentation	0.60056209
100	MP0003890_abnormal_embryonic-extraembry	0.55287970

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased circulating renin level (HP:0003351)	6.59186908
2	Intrahepatic cholestasis (HP:0001406)	6.37087690
3	Hyperactive renin-angiotensin system (HP:0000841)	5.75501706
4	Chronic bronchitis (HP:0004469)	4.96789871
5	Hypokalemic alkalosis (HP:0001949)	4.28510019
6	Enlarged epiphyses (HP:0010580)	4.22220114
7	Neonatal onset (HP:0003623)	4.15911034
8	Bilateral sensorineural hearing impairment (HP:0008619)	4.02688498
9	Pancreatic cysts (HP:0001737)	3.54280500
10	Abnormality of dentin (HP:0010299)	3.35548853
11	Steatorrhea (HP:0002570)	3.30903893
12	Abnormality of renin-angiotensin system (HP:0000847)	3.24395147
13	Concave nail (HP:0001598)	3.20992174
14	Renal salt wasting (HP:0000127)	3.17685234
15	Genetic anticipation (HP:0003743)	3.11750785
16	Molar tooth sign on MRI (HP:0002419)	3.07301489
17	Abnormality of midbrain morphology (HP:0002418)	3.07301489
18	Hyperaldosteronism (HP:0000859)	3.02596663
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.00513988
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.00513988
21	True hermaphroditism (HP:0010459)	3.00400961
22	Shawl scrotum (HP:0000049)	2.97864034
23	Abnormality of the pons (HP:0007361)	2.94261154
24	Hypoplasia of the pons (HP:0012110)	2.93588914
25	Pancreatic fibrosis (HP:0100732)	2.90113466
26	Hyperkalemia (HP:0002153)	2.90110747
27	Bilateral microphthalmos (HP:0007633)	2.89427058
28	Increased hepatocellular lipid droplets (HP:0006565)	2.71205588
29	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.70961273
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.64377923
31	Absent/shortened dynein arms (HP:0200106)	2.64377923
32	Abnormal biliary tract physiology (HP:0012439)	2.63452378
33	Bile duct proliferation (HP:0001408)	2.63452378
34	Abnormal ciliary motility (HP:0012262)	2.62368914
35	Abnormality of the vertebral endplates (HP:0005106)	2.60665078
36	Hypoplastic ischia (HP:0003175)	2.59275783
37	Methylmalonic acidemia (HP:0002912)	2.57910515
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.56572086
39	Alkalosis (HP:0001948)	2.53861857
40	Epileptic encephalopathy (HP:0200134)	2.48185486
41	Sclerocornea (HP:0000647)	2.46855622
42	Epidermoid cyst (HP:0200040)	2.42837627
43	Renal Fanconi syndrome (HP:0001994)	2.41427982
44	Fat malabsorption (HP:0002630)	2.36753549
45	Abnormal pancreas size (HP:0012094)	2.31507816
46	Polydipsia (HP:0001959)	2.30835737
47	Abnormal drinking behavior (HP:0030082)	2.30835737
48	Bronchitis (HP:0012387)	2.30183837
49	Poor suck (HP:0002033)	2.29137164
50	Cystic liver disease (HP:0006706)	2.28258356
51	Hypokalemia (HP:0002900)	2.28073556
52	Bronchiectasis (HP:0002110)	2.26111183
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24408341
54	Abnormality of the ischium (HP:0003174)	2.22225250
55	Febrile seizures (HP:0002373)	2.19640016
56	Exertional dyspnea (HP:0002875)	2.18822187
57	Delayed CNS myelination (HP:0002188)	2.15497804
58	Agnosia (HP:0010524)	2.14893188
59	Pendular nystagmus (HP:0012043)	2.13444921
60	Conical tooth (HP:0000698)	2.11194529
61	Lipid accumulation in hepatocytes (HP:0006561)	2.10270576
62	Hypothermia (HP:0002045)	2.08410824
63	Hyperglycinemia (HP:0002154)	2.07472303
64	Tinnitus (HP:0000360)	2.05937905
65	Abnormality of the dental pulp (HP:0006479)	2.04631583
66	Tented upper lip vermilion (HP:0010804)	2.02721081
67	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.02570327
68	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.02570327
69	Optic nerve coloboma (HP:0000588)	2.02431339
70	Anencephaly (HP:0002323)	2.01380001
71	Chronic hepatic failure (HP:0100626)	12.1106934
72	Abnormal number of incisors (HP:0011064)	1.99987038
73	Nephronophthisis (HP:0000090)	1.97622462
74	Increased corneal curvature (HP:0100692)	1.97608245
75	Keratoconus (HP:0000563)	1.97608245
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.97005411
77	IgM deficiency (HP:0002850)	1.94895090
78	Onycholysis (HP:0001806)	1.94262262
79	Rhinitis (HP:0012384)	1.93832009
80	Abnormality of the femoral head (HP:0003368)	1.91951795
81	Urinary bladder sphincter dysfunction (HP:0002839)	1.86952655
82	Acute necrotizing encephalopathy (HP:0006965)	1.86191498
83	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.85412081
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.85029020
85	Maternal diabetes (HP:0009800)	1.84106909
86	Anophthalmia (HP:0000528)	1.83625354
87	Abnormality of the pubic bones (HP:0003172)	1.83146626
88	Increased intramyocellular lipid droplets (HP:0012240)	1.81717924
89	Abolished electroretinogram (ERG) (HP:0000550)	1.78314847
90	Abnormality of the renal cortex (HP:0011035)	1.78022939
91	Hyponatremia (HP:0002902)	1.77620414
92	Limb dystonia (HP:0002451)	1.75748297
93	Status epilepticus (HP:0002133)	1.75350007
94	Flattened epiphyses (HP:0003071)	1.72638889
95	Chronic sinusitis (HP:0011109)	1.72476874
96	Abnormality of renal resorption (HP:0011038)	1.71394739
97	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70144241
98	Hyperlipoproteinemia (HP:0010980)	1.70098219
99	Aplasia cutis congenita (HP:0001057)	1.69889915
100	Decreased central vision (HP:0007663)	1.69001847

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	7.62239241
2	SIK3	4.99484326
3	PASK	3.43325479
4	CDK19	3.28356815
5	MUSK	2.99704880
6	DDR2	2.86608899
7	SIK1	2.48279041
8	MAP3K11	2.29554013
9	WNK3	2.27856199
10	MARK1	1.98727503
11	MAP2K7	1.98450858
12	PINK1	1.75831900
13	MARK3	1.66713944
14	MAP3K4	1.63943578
15	TAOK3	1.63374590
16	ADRBK2	1.62987803
17	NME1	1.62220522
18	LIMK1	1.59568456
19	CASK	1.58488566
20	TESK2	1.54684200
21	PNCK	1.47159779
22	NUAK1	1.41215194
23	TYRO3	1.34852833
24	MAPK15	1.33107993
25	MAP3K9	1.28352846
26	MAPK13	1.25923550
27	VRK2	1.25110574
28	ZAK	1.20351951
29	MAP4K2	1.19229279
30	TESK1	1.18839592
31	TGFBR1	1.11886761
32	TEC	1.05409184
33	ARAF	1.05255020
34	TXK	1.04233353
35	GRK1	0.98441263
36	CAMK2B	0.96370394
37	NEK1	0.96327808
38	BMPR1B	0.96168330
39	FRK	0.91994055
40	MINK1	0.91674485
41	DYRK3	0.86515191
42	PRKCG	0.78977133
43	VRK1	0.77402495
44	NTRK3	0.73575116
45	MAP2K4	0.73407642
46	ADRBK1	0.69629543
47	DYRK2	0.67356235
48	PHKG2	0.66807217
49	PHKG1	0.66807217
50	BTK	0.65976487
51	TAOK1	0.65118593
52	INSRR	0.64238677
53	BCKDK	0.60356824
54	TNIK	0.59045074
55	IKBKE	0.57381471
56	BCR	0.57219516
57	OBSCN	0.56639502
58	MAP3K12	0.56122151
59	KIT	0.56089521
60	CDK11A	0.54851828
61	CAMK2A	0.53159942
62	ITK	0.52988776
63	SCYL2	0.52901017
64	PRKACA	0.51355366
65	MAPKAPK5	0.49255256
66	MARK2	0.45029778
67	CDK5	0.43793865
68	MAP2K2	0.43030963
69	PRKAA1	0.42857800
70	PRKG2	0.41291580
71	GRK6	0.41100451
72	PIK3CG	0.40660003
73	MOS	0.39466742
74	CHEK2	0.39073658
75	STK11	0.38680931
76	CDK14	0.38366798
77	PRKCE	0.38289657
78	DAPK2	0.37290158
79	DMPK	0.37269956
80	IRAK3	0.35917922
81	TRIM28	0.35544088
82	CDK18	0.35464251
83	PRKCZ	0.34034352
84	IKBKB	0.33410515
85	CDK15	0.33388210
86	CAMK2G	0.33237625
87	PLK4	0.32873179
88	PAK6	0.31687516
89	TGFBR2	0.31221743
90	TLK1	0.31143290
91	PRKCQ	0.29949701
92	CHUK	0.28766018
93	GRK7	0.28601503
94	RPS6KA5	0.28409417
95	DYRK1A	0.28209718
96	LATS1	0.26382535
97	RPS6KA6	0.25813728
98	DYRK1B	0.24678966
99	PRKG1	0.23275196
100	PRKCA	0.20870584

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	5.23621199
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.28043211
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19180299
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.00654861
5	Nicotine addiction_Homo sapiens_hsa05033	2.98163406
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.67926548
7	Taste transduction_Homo sapiens_hsa04742	2.67171188
8	Ribosome_Homo sapiens_hsa03010	2.55963583
9	Parkinsons disease_Homo sapiens_hsa05012	2.55305341
10	Alzheimers disease_Homo sapiens_hsa05010	2.18414888
11	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.16749855
12	Phototransduction_Homo sapiens_hsa04744	2.06507819
13	Morphine addiction_Homo sapiens_hsa05032	2.03089071
14	Circadian entrainment_Homo sapiens_hsa04713	1.94160623
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89458732
16	Huntingtons disease_Homo sapiens_hsa05016	1.88533360
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88465897
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81948052
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.73033852
20	Olfactory transduction_Homo sapiens_hsa04740	1.68862748
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.56280219
22	GABAergic synapse_Homo sapiens_hsa04727	1.55241941
23	Caffeine metabolism_Homo sapiens_hsa00232	1.53289290
24	Cocaine addiction_Homo sapiens_hsa05030	1.48397148
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44342036
26	Histidine metabolism_Homo sapiens_hsa00340	1.38447502
27	Amphetamine addiction_Homo sapiens_hsa05031	1.30702170
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.27948803
29	Proteasome_Homo sapiens_hsa03050	1.25956195
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25871155
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.25201660
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.23989961
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23508625
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21617217
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.14006108
36	Basal cell carcinoma_Homo sapiens_hsa05217	1.09712017
37	Gastric acid secretion_Homo sapiens_hsa04971	1.07871170
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06957152
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.06307113
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.06106863
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.05787816
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.04133819
43	Retinol metabolism_Homo sapiens_hsa00830	0.99831219
44	Regulation of autophagy_Homo sapiens_hsa04140	0.97917021
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97721032
46	ABC transporters_Homo sapiens_hsa02010	0.96921484
47	Peroxisome_Homo sapiens_hsa04146	0.91757839
48	Basal transcription factors_Homo sapiens_hsa03022	0.88169402
49	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.80978806
50	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.79404855
51	Serotonergic synapse_Homo sapiens_hsa04726	0.78575793
52	Insulin secretion_Homo sapiens_hsa04911	0.77796081
53	Cholinergic synapse_Homo sapiens_hsa04725	0.77017822
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.76158747
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75728551
56	Salivary secretion_Homo sapiens_hsa04970	0.70389270
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.68288863
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68230418
59	Axon guidance_Homo sapiens_hsa04360	0.62633198
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62512523
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60314224
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58913623
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56821742
64	Ras signaling pathway_Homo sapiens_hsa04014	0.55650492
65	One carbon pool by folate_Homo sapiens_hsa00670	0.53950612
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.52315052
67	Folate biosynthesis_Homo sapiens_hsa00790	0.51747963
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.50028180
69	Metabolic pathways_Homo sapiens_hsa01100	0.49864320
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49634838
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46378009
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.42995211
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.41903552
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41598962
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40762414
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.40439568
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38209986
78	Renin secretion_Homo sapiens_hsa04924	0.34423221
79	Alcoholism_Homo sapiens_hsa05034	0.34337560
80	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33201010
81	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33142799
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30196585
83	Melanogenesis_Homo sapiens_hsa04916	0.30087747
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29757092
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.29500297
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27764538
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27569999
88	RNA polymerase_Homo sapiens_hsa03020	0.25881897
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.25305360
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24403648
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24032659
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.23880932
93	Protein export_Homo sapiens_hsa03060	0.22590754
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22531238
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.22120709
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.20456439
97	Bile secretion_Homo sapiens_hsa04976	0.19377843
98	Purine metabolism_Homo sapiens_hsa00230	0.18810944
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.17556251
100	African trypanosomiasis_Homo sapiens_hsa05143	0.17138035

MRPL2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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