MRPL2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)7.48099366
2sequestering of actin monomers (GO:0042989)7.39403905
3sterol catabolic process (GO:0016127)7.29975427
4cholesterol catabolic process (GO:0006707)7.29975427
5fusion of sperm to egg plasma membrane (GO:0007342)7.10519366
6sperm capacitation (GO:0048240)6.36095301
7positive regulation of sodium ion transmembrane transporter activity (GO:2000651)6.31630807
8multicellular organism reproduction (GO:0032504)6.07379667
9protein-chromophore linkage (GO:0018298)5.91802697
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.46364841
11plasma membrane fusion (GO:0045026)5.43522769
12positive regulation of gastrulation (GO:2000543)5.40970171
13membrane depolarization during action potential (GO:0086010)5.25985898
14regulation of cell communication by electrical coupling (GO:0010649)5.22916301
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.22388139
16regulation of acrosome reaction (GO:0060046)5.20154761
17serotonin metabolic process (GO:0042428)5.19685359
18positive regulation of sodium ion transmembrane transport (GO:1902307)5.13895954
19neuronal action potential (GO:0019228)4.83984821
20calcium ion import (GO:0070509)4.79896076
21ATP synthesis coupled proton transport (GO:0015986)4.75315293
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75315293
23primary amino compound metabolic process (GO:1901160)4.69665799
24regulation of action potential (GO:0098900)4.53825953
25positive regulation of membrane potential (GO:0045838)4.30376736
26sleep (GO:0030431)4.18003245
27reproduction (GO:0000003)3.89657662
28steroid catabolic process (GO:0006706)3.82272671
29negative regulation of telomere maintenance (GO:0032205)3.70682811
30histone H4-K12 acetylation (GO:0043983)3.58848952
31response to pheromone (GO:0019236)3.56379201
32bile acid biosynthetic process (GO:0006699)3.55107843
33rhodopsin mediated signaling pathway (GO:0016056)3.54862629
34protein targeting to plasma membrane (GO:0072661)3.53120284
35sperm-egg recognition (GO:0035036)3.49580989
36primitive streak formation (GO:0090009)3.45516258
37indole-containing compound metabolic process (GO:0042430)3.38462781
38tachykinin receptor signaling pathway (GO:0007217)3.33803971
39ovulation cycle (GO:0042698)3.31488459
40C21-steroid hormone metabolic process (GO:0008207)3.27383646
41skeletal muscle tissue regeneration (GO:0043403)3.26322653
42sperm motility (GO:0030317)3.24516038
43axonemal dynein complex assembly (GO:0070286)3.24467150
44positive regulation of embryonic development (GO:0040019)3.23280665
45positive regulation of uterine smooth muscle contraction (GO:0070474)3.20027864
46positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.18955451
47membrane assembly (GO:0071709)3.16009099
48positive regulation of T cell differentiation in thymus (GO:0033089)3.10241272
49regulation of gonadotropin secretion (GO:0032276)3.10039095
50dorsal/ventral neural tube patterning (GO:0021904)3.07434411
51behavioral response to ethanol (GO:0048149)3.06701037
52cell-cell recognition (GO:0009988)3.03981878
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.00430112
54cell proliferation involved in metanephros development (GO:0072203)3.00002196
55positive regulation of protein complex disassembly (GO:0043243)2.98299970
56regulation of calcium ion-dependent exocytosis (GO:0017158)2.94746778
57positive regulation of oligodendrocyte differentiation (GO:0048714)2.89280975
58behavioral response to nicotine (GO:0035095)2.86967963
59cilium or flagellum-dependent cell motility (GO:0001539)2.86359059
60regulation of homotypic cell-cell adhesion (GO:0034110)2.84816308
61kynurenine metabolic process (GO:0070189)2.84080428
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.83841969
63C4-dicarboxylate transport (GO:0015740)2.81913590
64ATP biosynthetic process (GO:0006754)2.81638297
65regulation of protein targeting to membrane (GO:0090313)2.80989943
66androgen metabolic process (GO:0008209)2.80245177
67regulation of mesenchymal cell apoptotic process (GO:2001053)2.79291353
68circadian sleep/wake cycle process (GO:0022410)2.77879672
69auditory behavior (GO:0031223)2.77456939
70positive regulation of protein targeting to membrane (GO:0090314)2.74624376
71neuron cell-cell adhesion (GO:0007158)2.74265119
72righting reflex (GO:0060013)2.74188838
73response to gravity (GO:0009629)2.73168962
74lung lobe morphogenesis (GO:0060463)2.68993705
75positive regulation of sodium ion transport (GO:0010765)2.67276951
76hydrogen ion transmembrane transport (GO:1902600)2.66556033
77spinal cord association neuron differentiation (GO:0021527)2.64083258
78positive regulation of protein depolymerization (GO:1901881)2.63442342
79positive regulation of vascular permeability (GO:0043117)2.63009706
80growth hormone secretion (GO:0030252)2.59166833
81exploration behavior (GO:0035640)2.58097452
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57139823
83regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56867159
84negative regulation of kidney development (GO:0090185)2.56211436
85response to dietary excess (GO:0002021)2.56123062
86somite rostral/caudal axis specification (GO:0032525)2.55729779
87action potential (GO:0001508)2.55553058
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54338184
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54338184
90neurofilament cytoskeleton organization (GO:0060052)2.54276796
91cAMP catabolic process (GO:0006198)2.53911231
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51285449
93thalamus development (GO:0021794)2.51259772
94reflex (GO:0060004)2.50556226
95protein polyglutamylation (GO:0018095)2.49089179
96neuroblast proliferation (GO:0007405)2.48527325
97DNA methylation involved in gamete generation (GO:0043046)2.47664585
98membrane depolarization (GO:0051899)2.47111700
99positive regulation of neurotransmitter secretion (GO:0001956)2.46409091
100neurotransmitter biosynthetic process (GO:0042136)2.45320204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78984373
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.99017936
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.26022704
4VDR_22108803_ChIP-Seq_LS180_Human3.59924869
5GBX2_23144817_ChIP-Seq_PC3_Human3.00153741
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77737607
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70336911
8TAF15_26573619_Chip-Seq_HEK293_Human2.57823827
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53201058
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28099465
11ZNF274_21170338_ChIP-Seq_K562_Hela2.26520755
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25611636
13EGR1_19032775_ChIP-ChIP_M12_Human2.16095179
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.15461480
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.06905378
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.05459632
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87025808
18RNF2_27304074_Chip-Seq_NSC_Mouse1.85533343
19REST_21632747_ChIP-Seq_MESCs_Mouse1.85172992
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.84573380
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84150852
22BCAT_22108803_ChIP-Seq_LS180_Human1.79397131
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77845793
24AR_21572438_ChIP-Seq_LNCaP_Human1.75647196
25P300_19829295_ChIP-Seq_ESCs_Human1.70071969
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67787702
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.60433653
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59260958
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.56961015
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55252722
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49100845
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47084739
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46942016
34FUS_26573619_Chip-Seq_HEK293_Human1.42770021
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41586417
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.40636137
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39229683
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37229373
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37102450
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36969422
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36525903
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35616421
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35105419
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33776114
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29804809
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29184820
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28159851
48AR_20517297_ChIP-Seq_VCAP_Human1.27458436
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25955257
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25840089
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.25337315
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25014607
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.24890030
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22476281
55TAF2_19829295_ChIP-Seq_ESCs_Human1.21851677
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.20196528
57SMAD4_21799915_ChIP-Seq_A2780_Human1.18364009
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.16251774
59MYC_18940864_ChIP-ChIP_HL60_Human1.15875589
60KDM2B_26808549_Chip-Seq_REH_Human1.14136260
61ERA_21632823_ChIP-Seq_H3396_Human1.14105698
62NANOG_20526341_ChIP-Seq_ESCs_Human1.12930221
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12637633
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.08914821
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08588811
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07918379
67ER_23166858_ChIP-Seq_MCF-7_Human1.06895288
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06399382
69DROSHA_22980978_ChIP-Seq_HELA_Human1.05579229
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05110263
71CTCF_27219007_Chip-Seq_Bcells_Human1.03145995
72TCF4_23295773_ChIP-Seq_U87_Human1.02804803
73RUNX2_22187159_ChIP-Seq_PCA_Human1.00342830
74STAT3_23295773_ChIP-Seq_U87_Human1.00306514
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00157350
76EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99881507
77RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99881507
78AR_25329375_ChIP-Seq_VCAP_Human0.98287470
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97329978
80NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97004313
81SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95717779
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93152525
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93077073
84TP53_22573176_ChIP-Seq_HFKS_Human0.89262189
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89046580
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89036461
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88273033
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88189543
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87095282
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87046229
91RING1B_27294783_Chip-Seq_ESCs_Mouse0.86461890
92MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85350845
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.85097794
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83961804
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83848224
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82539613
97TP53_18474530_ChIP-ChIP_U2OS_Human0.81906122
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81554240
99SOX2_19829295_ChIP-Seq_ESCs_Human0.81212503
100NANOG_19829295_ChIP-Seq_ESCs_Human0.81212503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex6.42222351
2MP0003283_abnormal_digestive_organ6.38275129
3MP0002822_catalepsy4.11830341
4MP0009379_abnormal_foot_pigmentation4.01140572
5MP0004043_abnormal_pH_regulation2.99847308
6MP0004133_heterotaxia2.63955542
7MP0000569_abnormal_digit_pigmentation2.53665162
8MP0004142_abnormal_muscle_tone2.29833798
9MP0008995_early_reproductive_senescence2.27069490
10MP0003646_muscle_fatigue2.26146684
11MP0001986_abnormal_taste_sensitivity2.24981349
12MP0008877_abnormal_DNA_methylation2.04780098
13MP0000372_irregular_coat_pigmentation2.00498684
14MP0001764_abnormal_homeostasis1.97678303
15MP0005379_endocrine/exocrine_gland_phen1.96987174
16MP0002102_abnormal_ear_morphology1.96440935
17MP0004859_abnormal_synaptic_plasticity1.93931179
18MP0001968_abnormal_touch/_nociception1.93812398
19MP0002064_seizures1.88854767
20MP0001905_abnormal_dopamine_level1.84201782
21MP0002736_abnormal_nociception_after1.79088418
22MP0009745_abnormal_behavioral_response1.75325147
23MP0004885_abnormal_endolymph1.67894111
24MP0003315_abnormal_perineum_morphology1.66713191
25MP0003195_calcinosis1.63246549
26MP0005253_abnormal_eye_physiology1.59646135
27MP0002735_abnormal_chemical_nociception1.57628753
28MP0008961_abnormal_basal_metabolism1.50001551
29MP0002234_abnormal_pharynx_morphology1.45063465
30MP0000566_synostosis1.44175464
31MP0002653_abnormal_ependyma_morphology1.43677677
32MP0001501_abnormal_sleep_pattern1.43290241
33MP0001502_abnormal_circadian_rhythm1.39256456
34MP0004510_myositis1.37834518
35MP0000383_abnormal_hair_follicle1.36629404
36MP0004019_abnormal_vitamin_homeostasis1.33920111
37MP0003635_abnormal_synaptic_transmissio1.30346247
38MP0004145_abnormal_muscle_electrophysio1.28336566
39MP0003011_delayed_dark_adaptation1.26363951
40MP0003119_abnormal_digestive_system1.24296498
41MP0002572_abnormal_emotion/affect_behav1.22442863
42MP0004147_increased_porphyrin_level1.19557676
43MP0000778_abnormal_nervous_system1.18801121
44MP0002837_dystrophic_cardiac_calcinosis1.18791285
45MP0002168_other_aberrant_phenotype1.18748010
46MP0002909_abnormal_adrenal_gland1.18484078
47MP0003136_yellow_coat_color1.18452322
48MP0003950_abnormal_plasma_membrane1.13156265
49MP0002272_abnormal_nervous_system1.12468895
50MP0005551_abnormal_eye_electrophysiolog1.11231259
51MP0003191_abnormal_cellular_cholesterol1.11225078
52MP0002938_white_spotting1.10739142
53MP0008057_abnormal_DNA_replication1.08681871
54MP0005187_abnormal_penis_morphology1.07148349
55MP0003938_abnormal_ear_development1.05622483
56MP0000750_abnormal_muscle_regeneration1.05257110
57MP0002277_abnormal_respiratory_mucosa1.03938279
58MP0005646_abnormal_pituitary_gland0.99897882
59MP0001873_stomach_inflammation0.99579885
60MP0002734_abnormal_mechanical_nocicepti0.99441165
61MP0000955_abnormal_spinal_cord0.99275190
62MP0009053_abnormal_anal_canal0.97152085
63MP0002067_abnormal_sensory_capabilities0.96633215
64MP0005365_abnormal_bile_salt0.95513143
65MP0005423_abnormal_somatic_nervous0.92098664
66MP0003787_abnormal_imprinting0.91691170
67MP0002733_abnormal_thermal_nociception0.88047157
68MP0009046_muscle_twitch0.87641843
69MP0002557_abnormal_social/conspecific_i0.86762721
70MP0002928_abnormal_bile_duct0.86113581
71MP0005395_other_phenotype0.85853113
72MP0003137_abnormal_impulse_conducting0.85771795
73MP0004130_abnormal_muscle_cell0.84489289
74MP0002063_abnormal_learning/memory/cond0.83442084
75MP0005360_urolithiasis0.83286985
76MP0000026_abnormal_inner_ear0.82414967
77MP0001188_hyperpigmentation0.81729569
78MP0001348_abnormal_lacrimal_gland0.81595226
79MP0005195_abnormal_posterior_eye0.80182469
80MP0002184_abnormal_innervation0.77087342
81MP0002095_abnormal_skin_pigmentation0.76031676
82MP0002882_abnormal_neuron_morphology0.74998653
83MP0005377_hearing/vestibular/ear_phenot0.74345028
84MP0003878_abnormal_ear_physiology0.74345028
85MP0002752_abnormal_somatic_nervous0.74243446
86MP0005084_abnormal_gallbladder_morpholo0.72940320
87MP0001486_abnormal_startle_reflex0.72100379
88MP0001970_abnormal_pain_threshold0.71062980
89MP0010678_abnormal_skin_adnexa0.68874058
90MP0002066_abnormal_motor_capabilities/c0.67625391
91MP0003718_maternal_effect0.66480432
92MP0004270_analgesia0.63936411
93MP0001293_anophthalmia0.62801146
94MP0003806_abnormal_nucleotide_metabolis0.62115652
95MP0005391_vision/eye_phenotype0.61725232
96MP0009643_abnormal_urine_homeostasis0.61246553
97MP0000534_abnormal_ureter_morphology0.60403921
98MP0000631_abnormal_neuroendocrine_gland0.60252586
99MP0001324_abnormal_eye_pigmentation0.60056209
100MP0003890_abnormal_embryonic-extraembry0.55287970

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)6.59186908
2Intrahepatic cholestasis (HP:0001406)6.37087690
3Hyperactive renin-angiotensin system (HP:0000841)5.75501706
4Chronic bronchitis (HP:0004469)4.96789871
5Hypokalemic alkalosis (HP:0001949)4.28510019
6Enlarged epiphyses (HP:0010580)4.22220114
7Neonatal onset (HP:0003623)4.15911034
8Bilateral sensorineural hearing impairment (HP:0008619)4.02688498
9Pancreatic cysts (HP:0001737)3.54280500
10Abnormality of dentin (HP:0010299)3.35548853
11Steatorrhea (HP:0002570)3.30903893
12Abnormality of renin-angiotensin system (HP:0000847)3.24395147
13Concave nail (HP:0001598)3.20992174
14Renal salt wasting (HP:0000127)3.17685234
15Genetic anticipation (HP:0003743)3.11750785
16Molar tooth sign on MRI (HP:0002419)3.07301489
17Abnormality of midbrain morphology (HP:0002418)3.07301489
18Hyperaldosteronism (HP:0000859)3.02596663
19Abnormal respiratory motile cilium morphology (HP:0005938)3.00513988
20Abnormal respiratory epithelium morphology (HP:0012253)3.00513988
21True hermaphroditism (HP:0010459)3.00400961
22Shawl scrotum (HP:0000049)2.97864034
23Abnormality of the pons (HP:0007361)2.94261154
24Hypoplasia of the pons (HP:0012110)2.93588914
25Pancreatic fibrosis (HP:0100732)2.90113466
26Hyperkalemia (HP:0002153)2.90110747
27Bilateral microphthalmos (HP:0007633)2.89427058
28Increased hepatocellular lipid droplets (HP:0006565)2.71205588
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70961273
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.64377923
31Absent/shortened dynein arms (HP:0200106)2.64377923
32Abnormal biliary tract physiology (HP:0012439)2.63452378
33Bile duct proliferation (HP:0001408)2.63452378
34Abnormal ciliary motility (HP:0012262)2.62368914
35Abnormality of the vertebral endplates (HP:0005106)2.60665078
36Hypoplastic ischia (HP:0003175)2.59275783
37Methylmalonic acidemia (HP:0002912)2.57910515
38Abnormal respiratory motile cilium physiology (HP:0012261)2.56572086
39Alkalosis (HP:0001948)2.53861857
40Epileptic encephalopathy (HP:0200134)2.48185486
41Sclerocornea (HP:0000647)2.46855622
42Epidermoid cyst (HP:0200040)2.42837627
43Renal Fanconi syndrome (HP:0001994)2.41427982
44Fat malabsorption (HP:0002630)2.36753549
45Abnormal pancreas size (HP:0012094)2.31507816
46Polydipsia (HP:0001959)2.30835737
47Abnormal drinking behavior (HP:0030082)2.30835737
48Bronchitis (HP:0012387)2.30183837
49Poor suck (HP:0002033)2.29137164
50Cystic liver disease (HP:0006706)2.28258356
51Hypokalemia (HP:0002900)2.28073556
52Bronchiectasis (HP:0002110)2.26111183
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24408341
54Abnormality of the ischium (HP:0003174)2.22225250
55Febrile seizures (HP:0002373)2.19640016
56Exertional dyspnea (HP:0002875)2.18822187
57Delayed CNS myelination (HP:0002188)2.15497804
58Agnosia (HP:0010524)2.14893188
59Pendular nystagmus (HP:0012043)2.13444921
60Conical tooth (HP:0000698)2.11194529
61Lipid accumulation in hepatocytes (HP:0006561)2.10270576
62Hypothermia (HP:0002045)2.08410824
63Hyperglycinemia (HP:0002154)2.07472303
64Tinnitus (HP:0000360)2.05937905
65Abnormality of the dental pulp (HP:0006479)2.04631583
66Tented upper lip vermilion (HP:0010804)2.02721081
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.02570327
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02570327
69Optic nerve coloboma (HP:0000588)2.02431339
70Anencephaly (HP:0002323)2.01380001
71Chronic hepatic failure (HP:0100626)12.1106934
72Abnormal number of incisors (HP:0011064)1.99987038
73Nephronophthisis (HP:0000090)1.97622462
74Increased corneal curvature (HP:0100692)1.97608245
75Keratoconus (HP:0000563)1.97608245
76Abnormal rod and cone electroretinograms (HP:0008323)1.97005411
77IgM deficiency (HP:0002850)1.94895090
78Onycholysis (HP:0001806)1.94262262
79Rhinitis (HP:0012384)1.93832009
80Abnormality of the femoral head (HP:0003368)1.91951795
81Urinary bladder sphincter dysfunction (HP:0002839)1.86952655
82Acute necrotizing encephalopathy (HP:0006965)1.86191498
83Abnormality of the epiphysis of the femoral head (HP:0010574)1.85412081
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85029020
85Maternal diabetes (HP:0009800)1.84106909
86Anophthalmia (HP:0000528)1.83625354
87Abnormality of the pubic bones (HP:0003172)1.83146626
88Increased intramyocellular lipid droplets (HP:0012240)1.81717924
89Abolished electroretinogram (ERG) (HP:0000550)1.78314847
90Abnormality of the renal cortex (HP:0011035)1.78022939
91Hyponatremia (HP:0002902)1.77620414
92Limb dystonia (HP:0002451)1.75748297
93Status epilepticus (HP:0002133)1.75350007
94Flattened epiphyses (HP:0003071)1.72638889
95Chronic sinusitis (HP:0011109)1.72476874
96Abnormality of renal resorption (HP:0011038)1.71394739
97Abnormal mitochondria in muscle tissue (HP:0008316)1.70144241
98Hyperlipoproteinemia (HP:0010980)1.70098219
99Aplasia cutis congenita (HP:0001057)1.69889915
100Decreased central vision (HP:0007663)1.69001847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK27.62239241
2SIK34.99484326
3PASK3.43325479
4CDK193.28356815
5MUSK2.99704880
6DDR22.86608899
7SIK12.48279041
8MAP3K112.29554013
9WNK32.27856199
10MARK11.98727503
11MAP2K71.98450858
12PINK11.75831900
13MARK31.66713944
14MAP3K41.63943578
15TAOK31.63374590
16ADRBK21.62987803
17NME11.62220522
18LIMK11.59568456
19CASK1.58488566
20TESK21.54684200
21PNCK1.47159779
22NUAK11.41215194
23TYRO31.34852833
24MAPK151.33107993
25MAP3K91.28352846
26MAPK131.25923550
27VRK21.25110574
28ZAK1.20351951
29MAP4K21.19229279
30TESK11.18839592
31TGFBR11.11886761
32TEC1.05409184
33ARAF1.05255020
34TXK1.04233353
35GRK10.98441263
36CAMK2B0.96370394
37NEK10.96327808
38BMPR1B0.96168330
39FRK0.91994055
40MINK10.91674485
41DYRK30.86515191
42PRKCG0.78977133
43VRK10.77402495
44NTRK30.73575116
45MAP2K40.73407642
46ADRBK10.69629543
47DYRK20.67356235
48PHKG20.66807217
49PHKG10.66807217
50BTK0.65976487
51TAOK10.65118593
52INSRR0.64238677
53BCKDK0.60356824
54TNIK0.59045074
55IKBKE0.57381471
56BCR0.57219516
57OBSCN0.56639502
58MAP3K120.56122151
59KIT0.56089521
60CDK11A0.54851828
61CAMK2A0.53159942
62ITK0.52988776
63SCYL20.52901017
64PRKACA0.51355366
65MAPKAPK50.49255256
66MARK20.45029778
67CDK50.43793865
68MAP2K20.43030963
69PRKAA10.42857800
70PRKG20.41291580
71GRK60.41100451
72PIK3CG0.40660003
73MOS0.39466742
74CHEK20.39073658
75STK110.38680931
76CDK140.38366798
77PRKCE0.38289657
78DAPK20.37290158
79DMPK0.37269956
80IRAK30.35917922
81TRIM280.35544088
82CDK180.35464251
83PRKCZ0.34034352
84IKBKB0.33410515
85CDK150.33388210
86CAMK2G0.33237625
87PLK40.32873179
88PAK60.31687516
89TGFBR20.31221743
90TLK10.31143290
91PRKCQ0.29949701
92CHUK0.28766018
93GRK70.28601503
94RPS6KA50.28409417
95DYRK1A0.28209718
96LATS10.26382535
97RPS6KA60.25813728
98DYRK1B0.24678966
99PRKG10.23275196
100PRKCA0.20870584

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.23621199
2Selenocompound metabolism_Homo sapiens_hsa004503.28043211
3Oxidative phosphorylation_Homo sapiens_hsa001903.19180299
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.00654861
5Nicotine addiction_Homo sapiens_hsa050332.98163406
6Cardiac muscle contraction_Homo sapiens_hsa042602.67926548
7Taste transduction_Homo sapiens_hsa047422.67171188
8Ribosome_Homo sapiens_hsa030102.55963583
9Parkinsons disease_Homo sapiens_hsa050122.55305341
10Alzheimers disease_Homo sapiens_hsa050102.18414888
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.16749855
12Phototransduction_Homo sapiens_hsa047442.06507819
13Morphine addiction_Homo sapiens_hsa050322.03089071
14Circadian entrainment_Homo sapiens_hsa047131.94160623
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89458732
16Huntingtons disease_Homo sapiens_hsa050161.88533360
17Linoleic acid metabolism_Homo sapiens_hsa005911.88465897
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81948052
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73033852
20Olfactory transduction_Homo sapiens_hsa047401.68862748
21Ether lipid metabolism_Homo sapiens_hsa005651.56280219
22GABAergic synapse_Homo sapiens_hsa047271.55241941
23Caffeine metabolism_Homo sapiens_hsa002321.53289290
24Cocaine addiction_Homo sapiens_hsa050301.48397148
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44342036
26Histidine metabolism_Homo sapiens_hsa003401.38447502
27Amphetamine addiction_Homo sapiens_hsa050311.30702170
28Glutamatergic synapse_Homo sapiens_hsa047241.27948803
29Proteasome_Homo sapiens_hsa030501.25956195
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25871155
31Tryptophan metabolism_Homo sapiens_hsa003801.25201660
32Hedgehog signaling pathway_Homo sapiens_hsa043401.23989961
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.23508625
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21617217
35Dopaminergic synapse_Homo sapiens_hsa047281.14006108
36Basal cell carcinoma_Homo sapiens_hsa052171.09712017
37Gastric acid secretion_Homo sapiens_hsa049711.07871170
38Collecting duct acid secretion_Homo sapiens_hsa049661.06957152
39Fatty acid biosynthesis_Homo sapiens_hsa000611.06307113
40Calcium signaling pathway_Homo sapiens_hsa040201.06106863
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05787816
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04133819
43Retinol metabolism_Homo sapiens_hsa008300.99831219
44Regulation of autophagy_Homo sapiens_hsa041400.97917021
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97721032
46ABC transporters_Homo sapiens_hsa020100.96921484
47Peroxisome_Homo sapiens_hsa041460.91757839
48Basal transcription factors_Homo sapiens_hsa030220.88169402
49Synaptic vesicle cycle_Homo sapiens_hsa047210.80978806
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79404855
51Serotonergic synapse_Homo sapiens_hsa047260.78575793
52Insulin secretion_Homo sapiens_hsa049110.77796081
53Cholinergic synapse_Homo sapiens_hsa047250.77017822
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76158747
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75728551
56Salivary secretion_Homo sapiens_hsa049700.70389270
57Primary immunodeficiency_Homo sapiens_hsa053400.68288863
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68230418
59Axon guidance_Homo sapiens_hsa043600.62633198
60Arachidonic acid metabolism_Homo sapiens_hsa005900.62512523
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60314224
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58913623
63Chemical carcinogenesis_Homo sapiens_hsa052040.56821742
64Ras signaling pathway_Homo sapiens_hsa040140.55650492
65One carbon pool by folate_Homo sapiens_hsa006700.53950612
66Fat digestion and absorption_Homo sapiens_hsa049750.52315052
67Folate biosynthesis_Homo sapiens_hsa007900.51747963
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50028180
69Metabolic pathways_Homo sapiens_hsa011000.49864320
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.49634838
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46378009
72Tyrosine metabolism_Homo sapiens_hsa003500.42995211
73Nitrogen metabolism_Homo sapiens_hsa009100.41903552
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41598962
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.40762414
76cAMP signaling pathway_Homo sapiens_hsa040240.40439568
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38209986
78Renin secretion_Homo sapiens_hsa049240.34423221
79Alcoholism_Homo sapiens_hsa050340.34337560
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33201010
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33142799
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.30196585
83Melanogenesis_Homo sapiens_hsa049160.30087747
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.29757092
85Thyroid hormone synthesis_Homo sapiens_hsa049180.29500297
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27764538
87Vitamin digestion and absorption_Homo sapiens_hsa049770.27569999
88RNA polymerase_Homo sapiens_hsa030200.25881897
89Oxytocin signaling pathway_Homo sapiens_hsa049210.25305360
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24403648
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24032659
92Rheumatoid arthritis_Homo sapiens_hsa053230.23880932
93Protein export_Homo sapiens_hsa030600.22590754
94Ovarian steroidogenesis_Homo sapiens_hsa049130.22531238
95Wnt signaling pathway_Homo sapiens_hsa043100.22120709
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20456439
97Bile secretion_Homo sapiens_hsa049760.19377843
98Purine metabolism_Homo sapiens_hsa002300.18810944
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.17556251
100African trypanosomiasis_Homo sapiens_hsa051430.17138035

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