MRPL30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.01848022
2ATP synthesis coupled proton transport (GO:0015986)7.50806041
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.50806041
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.05003574
5ribosomal small subunit assembly (GO:0000028)7.03147184
6viral transcription (GO:0019083)6.85904454
7translational termination (GO:0006415)6.65388516
8respiratory electron transport chain (GO:0022904)6.64183284
9electron transport chain (GO:0022900)6.46647435
10ribosomal small subunit biogenesis (GO:0042274)6.21933204
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.10267516
12cotranslational protein targeting to membrane (GO:0006613)6.03326272
13protein targeting to ER (GO:0045047)5.98669190
14translational elongation (GO:0006414)5.82745946
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.71735075
16protein localization to endoplasmic reticulum (GO:0070972)5.68961701
17ribosomal large subunit biogenesis (GO:0042273)5.55088619
18maturation of SSU-rRNA (GO:0030490)5.51008786
19cellular protein complex disassembly (GO:0043624)5.22477060
20viral life cycle (GO:0019058)5.16801596
21translational initiation (GO:0006413)5.09013025
22protein complex biogenesis (GO:0070271)5.05598921
23oxidative phosphorylation (GO:0006119)5.01816234
24regulation of mitochondrial translation (GO:0070129)4.97887450
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.96021201
26NADH dehydrogenase complex assembly (GO:0010257)4.96021201
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.96021201
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89958313
29translation (GO:0006412)4.89761466
30mitochondrial respiratory chain complex assembly (GO:0033108)4.72708896
31proteasome assembly (GO:0043248)4.53436644
32DNA deamination (GO:0045006)4.45786090
33protein complex disassembly (GO:0043241)4.37103953
34maturation of 5.8S rRNA (GO:0000460)4.28246117
35macromolecular complex disassembly (GO:0032984)4.23759284
36termination of RNA polymerase III transcription (GO:0006386)4.22009845
37transcription elongation from RNA polymerase III promoter (GO:0006385)4.22009845
38CENP-A containing nucleosome assembly (GO:0034080)4.09127686
39chromatin remodeling at centromere (GO:0031055)4.08992884
40cellular component biogenesis (GO:0044085)3.98404020
41ribonucleoprotein complex biogenesis (GO:0022613)3.96936097
42chaperone-mediated protein transport (GO:0072321)3.95752534
43cullin deneddylation (GO:0010388)3.95160765
44protein targeting to membrane (GO:0006612)3.94103146
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.93645083
46respiratory chain complex IV assembly (GO:0008535)3.93550697
47ATP biosynthetic process (GO:0006754)3.92720206
48aerobic respiration (GO:0009060)3.90437572
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.88772508
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.85270665
51establishment of integrated proviral latency (GO:0075713)3.84817878
52ubiquinone biosynthetic process (GO:0006744)3.83737228
53quinone biosynthetic process (GO:1901663)3.83737228
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83613936
55DNA replication checkpoint (GO:0000076)3.83382236
56cytochrome complex assembly (GO:0017004)3.79771109
57protein targeting to mitochondrion (GO:0006626)3.79567756
58protein neddylation (GO:0045116)3.76570995
59GTP biosynthetic process (GO:0006183)3.74955565
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68862712
61IMP biosynthetic process (GO:0006188)3.66437531
62protein deneddylation (GO:0000338)3.66077173
63formation of translation preinitiation complex (GO:0001731)3.64631216
64regulation of cellular amino acid metabolic process (GO:0006521)3.64617371
65establishment of protein localization to mitochondrion (GO:0072655)3.63784709
66nuclear pore complex assembly (GO:0051292)3.62485107
67protein localization to kinetochore (GO:0034501)3.58024384
68inner mitochondrial membrane organization (GO:0007007)3.56601742
69mitotic metaphase plate congression (GO:0007080)3.55100275
70nuclear pore organization (GO:0006999)3.53829381
71ribonucleoside triphosphate biosynthetic process (GO:0009201)3.52513149
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.52427890
73DNA strand elongation involved in DNA replication (GO:0006271)3.50637009
74protein localization to mitochondrion (GO:0070585)3.48818715
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48396972
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48177840
77negative regulation of ligase activity (GO:0051352)3.47992852
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47992852
79histone exchange (GO:0043486)3.46871831
80purine nucleobase biosynthetic process (GO:0009113)3.44776288
81hydrogen ion transmembrane transport (GO:1902600)3.43279141
82IMP metabolic process (GO:0046040)3.41555966
83ubiquinone metabolic process (GO:0006743)3.41504119
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41347452
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36736376
86DNA strand elongation (GO:0022616)3.36014676
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33277794
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33277794
89nucleobase biosynthetic process (GO:0046112)3.32868021
90mRNA catabolic process (GO:0006402)3.32136505
91guanosine-containing compound biosynthetic process (GO:1901070)3.31235014
92regulation of centriole replication (GO:0046599)3.30328287
93rRNA processing (GO:0006364)3.29712470
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29421647
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29421647
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29421647
97pseudouridine synthesis (GO:0001522)3.29228558
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28729915
99UTP biosynthetic process (GO:0006228)3.27365731
100mitochondrial transport (GO:0006839)3.26442019
101DNA replication-independent nucleosome assembly (GO:0006336)3.25901775
102DNA replication-independent nucleosome organization (GO:0034724)3.25901775
103ribosome assembly (GO:0042255)3.25377038
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.22911287
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22911287
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20864771
107spliceosomal snRNP assembly (GO:0000387)3.20492715
108protein localization to chromosome, centromeric region (GO:0071459)3.19859933
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.19355161
110tricarboxylic acid cycle (GO:0006099)3.17755388
1117-methylguanosine mRNA capping (GO:0006370)3.15702533
112rRNA metabolic process (GO:0016072)3.14564762
113telomere maintenance via semi-conservative replication (GO:0032201)3.13233778
114nucleoside triphosphate biosynthetic process (GO:0009142)3.12889582
115RNA capping (GO:0036260)3.11685275
1167-methylguanosine RNA capping (GO:0009452)3.11685275
117cellular respiration (GO:0045333)3.11515208
118metallo-sulfur cluster assembly (GO:0031163)3.10745282
119iron-sulfur cluster assembly (GO:0016226)3.10745282
120ribosome biogenesis (GO:0042254)3.09416504
121regulation of translational fidelity (GO:0006450)3.08435055
122tRNA aminoacylation (GO:0043039)3.05704415
123amino acid activation (GO:0043038)3.05704415
124RNA catabolic process (GO:0006401)3.05343441
125UTP metabolic process (GO:0046051)3.03741606
126spliceosomal complex assembly (GO:0000245)3.02930166
127rRNA modification (GO:0000154)3.01477421
128tRNA aminoacylation for protein translation (GO:0006418)3.01044911
129metaphase plate congression (GO:0051310)3.00833975
130folic acid-containing compound biosynthetic process (GO:0009396)3.00104234
131transcription elongation from RNA polymerase I promoter (GO:0006362)2.94983196
132non-recombinational repair (GO:0000726)2.94340014
133double-strand break repair via nonhomologous end joining (GO:0006303)2.94340014
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89877477
135termination of RNA polymerase I transcription (GO:0006363)2.88435908
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87988511
137regulation of mitotic spindle checkpoint (GO:1903504)2.87988511
138DNA damage response, detection of DNA damage (GO:0042769)2.84997292
139mitotic sister chromatid segregation (GO:0000070)2.83845836
140establishment of viral latency (GO:0019043)2.82736608
141replication fork processing (GO:0031297)2.80721588
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.79791277
143DNA unwinding involved in DNA replication (GO:0006268)2.79490999
144protein K6-linked ubiquitination (GO:0085020)2.77092660
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76999343
146mitochondrial RNA metabolic process (GO:0000959)2.76370807
147telomere maintenance via recombination (GO:0000722)2.75951144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.16611366
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.61015135
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.53158342
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.27815812
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.20031701
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.18187191
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86916282
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.84765463
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.75553025
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38617366
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36640033
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.19499924
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09751622
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99838901
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.89308535
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76253520
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75495923
18DCP1A_22483619_ChIP-Seq_HELA_Human2.72875528
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72875373
20* VDR_23849224_ChIP-Seq_CD4+_Human2.72536978
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63343444
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.61522274
23E2F7_22180533_ChIP-Seq_HELA_Human2.53089540
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50434192
25XRN2_22483619_ChIP-Seq_HELA_Human2.45819146
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.44729317
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34296120
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31879493
29FOXP3_21729870_ChIP-Seq_TREG_Human2.30740679
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.22778828
31ELK1_19687146_ChIP-ChIP_HELA_Human2.21538541
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19998085
33TTF2_22483619_ChIP-Seq_HELA_Human2.18392783
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06096116
35* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02664863
36GABP_19822575_ChIP-Seq_HepG2_Human2.01645853
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00646993
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92488738
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91241781
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89775349
41* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88424305
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.84129498
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83728886
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81810743
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80373979
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78933758
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76751415
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69158074
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.68243091
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67599317
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57940681
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53487647
53EWS_26573619_Chip-Seq_HEK293_Human1.53061971
54FUS_26573619_Chip-Seq_HEK293_Human1.47696904
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46940174
56* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44340614
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42745956
58* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41973331
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41472616
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35556243
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34932408
62MYC_18940864_ChIP-ChIP_HL60_Human1.32280238
63* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.30090083
64VDR_22108803_ChIP-Seq_LS180_Human1.28009436
65ZNF274_21170338_ChIP-Seq_K562_Hela1.21869389
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.21579733
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.20491154
68* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19417035
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15214471
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12940636
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12051366
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12030734
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11809797
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09577733
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.08392190
76CIITA_25753668_ChIP-Seq_RAJI_Human1.08371419
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08151439
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07039993
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02609669
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02001083
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00272706
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00084358
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99015591
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98595045
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98235267
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97854100
87KDM5A_27292631_Chip-Seq_BREAST_Human0.96078183
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95602616
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93738658
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93082680
91BP1_19119308_ChIP-ChIP_Hs578T_Human0.89670033
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89604543
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.89288836
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.89258766
95* FLI1_27457419_Chip-Seq_LIVER_Mouse0.88922051
96IGF1R_20145208_ChIP-Seq_DFB_Human0.88055472
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87922902
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83943251
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83724856
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.82086076
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81028542
102* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80636868
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79956245
104* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79129838
105SPI1_23547873_ChIP-Seq_NB4_Human0.78323030
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76938952
107TFEB_21752829_ChIP-Seq_HELA_Human0.76493176
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76206069
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75772793
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74590082
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73605916
112IRF1_19129219_ChIP-ChIP_H3396_Human0.73499251
113GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72438646
114AR_21909140_ChIP-Seq_LNCAP_Human0.71719237
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71304199
116TP53_22573176_ChIP-Seq_HFKS_Human0.69404655
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68547476
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.68382366
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68151358
120TAF15_26573619_Chip-Seq_HEK293_Human0.67629272
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66359479
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65919632
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65890099
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65527740
125ELF5_23300383_ChIP-Seq_T47D_Human0.64485157
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.64183561
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63654601
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.63397999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.01350290
2MP0003646_muscle_fatigue4.25468575
3MP0006036_abnormal_mitochondrial_physio3.88045137
4MP0002837_dystrophic_cardiac_calcinosis3.74441212
5MP0003693_abnormal_embryo_hatching3.14771247
6MP0003186_abnormal_redox_activity2.94412117
7MP0000749_muscle_degeneration2.66214011
8MP0003806_abnormal_nucleotide_metabolis2.62959007
9MP0004957_abnormal_blastocyst_morpholog2.57617735
10MP0004215_abnormal_myocardial_fiber2.57187002
11MP0004084_abnormal_cardiac_muscle2.56987622
12MP0006035_abnormal_mitochondrial_morpho2.47086437
13MP0003890_abnormal_embryonic-extraembry2.34966058
14MP0003941_abnormal_skin_development2.27391072
15MP0005330_cardiomyopathy2.15281123
16MP0001529_abnormal_vocalization2.11626486
17MP0000751_myopathy1.99175117
18MP0001293_anophthalmia1.94856471
19MP0006292_abnormal_olfactory_placode1.92482186
20MP0001764_abnormal_homeostasis1.91252232
21MP0004036_abnormal_muscle_relaxation1.90869678
22MP0009697_abnormal_copulation1.89357777
23MP0004147_increased_porphyrin_level1.87594805
24MP0002163_abnormal_gland_morphology1.84128578
25MP0002132_abnormal_respiratory_system1.83801489
26MP0008932_abnormal_embryonic_tissue1.79850488
27MP0000372_irregular_coat_pigmentation1.75427242
28MP0010030_abnormal_orbit_morphology1.73526651
29MP0000750_abnormal_muscle_regeneration1.72033100
30MP0002102_abnormal_ear_morphology1.67430269
31MP0008877_abnormal_DNA_methylation1.66843774
32MP0008058_abnormal_DNA_repair1.59660927
33MP0003937_abnormal_limbs/digits/tail_de1.59407632
34MP0003077_abnormal_cell_cycle1.59386142
35MP0002638_abnormal_pupillary_reflex1.58910685
36MP0010094_abnormal_chromosome_stability1.58520337
37MP0003221_abnormal_cardiomyocyte_apopto1.57692611
38MP0003136_yellow_coat_color1.52256392
39MP0003656_abnormal_erythrocyte_physiolo1.51657635
40MP0003137_abnormal_impulse_conducting1.47997758
41MP0001697_abnormal_embryo_size1.46452766
42MP0006072_abnormal_retinal_apoptosis1.45880791
43MP0002234_abnormal_pharynx_morphology1.45249979
44MP0002972_abnormal_cardiac_muscle1.43702965
45MP0008775_abnormal_heart_ventricle1.39963013
46MP0001730_embryonic_growth_arrest1.38130367
47MP0003718_maternal_effect1.35646935
48MP0002084_abnormal_developmental_patter1.34949123
49MP0005380_embryogenesis_phenotype1.30669963
50MP0001672_abnormal_embryogenesis/_devel1.30669963
51MP0009333_abnormal_splenocyte_physiolog1.28383018
52MP0001853_heart_inflammation1.26798687
53MP0002085_abnormal_embryonic_tissue1.26026850
54MP0005385_cardiovascular_system_phenoty1.26008932
55MP0001544_abnormal_cardiovascular_syste1.26008932
56MP0003567_abnormal_fetal_cardiomyocyte1.24966818
57MP0003011_delayed_dark_adaptation1.24207052
58MP0000350_abnormal_cell_proliferation1.23572162
59MP0005187_abnormal_penis_morphology1.22636108
60MP0001286_abnormal_eye_development1.22143174
61MP0004145_abnormal_muscle_electrophysio1.20931009
62MP0003786_premature_aging1.20732089
63MP0002106_abnormal_muscle_physiology1.20709190
64MP0005084_abnormal_gallbladder_morpholo1.18694703
65MP0004484_altered_response_of1.17355622
66MP0008789_abnormal_olfactory_epithelium1.17176652
67MP0005620_abnormal_muscle_contractility1.16979344
68MP0009785_altered_susceptibility_to1.15502104
69MP0003984_embryonic_growth_retardation1.13701381
70MP0005266_abnormal_metabolism1.13299494
71MP0002210_abnormal_sex_determination1.12255182
72MP0002736_abnormal_nociception_after1.12078023
73MP0002088_abnormal_embryonic_growth/wei1.11341738
74MP0002148_abnormal_hypersensitivity_rea1.10394096
75MP0002697_abnormal_eye_size1.10294401
76MP0003195_calcinosis1.10253888
77MP0004087_abnormal_muscle_fiber1.09458533
78MP0005636_abnormal_mineral_homeostasis1.08082541
79MP0000358_abnormal_cell_content/1.07219517
80MP0000343_altered_response_to1.06919336
81MP0000647_abnormal_sebaceous_gland1.06592405
82MP0002080_prenatal_lethality1.06445818
83MP0003123_paternal_imprinting1.05425338
84MP0001929_abnormal_gametogenesis1.04216096
85MP0002233_abnormal_nose_morphology1.03511322
86MP0003119_abnormal_digestive_system1.03297155
87MP0005083_abnormal_biliary_tract1.03041576
88MP0002332_abnormal_exercise_endurance1.02431682
89MP0008004_abnormal_stomach_pH1.01156545
90MP0003111_abnormal_nucleus_morphology1.00414901
91MP0005332_abnormal_amino_acid0.99827198
92MP0003950_abnormal_plasma_membrane0.98341446
93MP0005369_muscle_phenotype0.98102342
94MP0010307_abnormal_tumor_latency0.97551474
95MP0004233_abnormal_muscle_weight0.97447921
96MP0000631_abnormal_neuroendocrine_gland0.96400081
97MP0004197_abnormal_fetal_growth/weight/0.96309060
98MP0003121_genomic_imprinting0.96078321
99MP0000490_abnormal_crypts_of0.94582270
100MP0002160_abnormal_reproductive_system0.94322307
101MP0002111_abnormal_tail_morphology0.94208705
102MP0002876_abnormal_thyroid_physiology0.93889268
103MP0005253_abnormal_eye_physiology0.93512599
104MP0001986_abnormal_taste_sensitivity0.93345729
105MP0008007_abnormal_cellular_replicative0.92950175
106MP0005376_homeostasis/metabolism_phenot0.92236456
107MP0004142_abnormal_muscle_tone0.91593475
108MP0000759_abnormal_skeletal_muscle0.90563057
109MP0002127_abnormal_cardiovascular_syste0.89870931
110MP0009672_abnormal_birth_weight0.89069801
111MP0001984_abnormal_olfaction0.89050347
112MP0001188_hyperpigmentation0.87295784
113MP0005391_vision/eye_phenotype0.87292520
114MP0001145_abnormal_male_reproductive0.86417485
115MP0001346_abnormal_lacrimal_gland0.86340784
116MP0004133_heterotaxia0.86281032
117MP0006276_abnormal_autonomic_nervous0.85937841
118MP0008995_early_reproductive_senescence0.85678509
119MP0001661_extended_life_span0.85330038
120MP0000653_abnormal_sex_gland0.85114475
121MP0001905_abnormal_dopamine_level0.84206329
122MP0003315_abnormal_perineum_morphology0.84021355
123MP0005165_increased_susceptibility_to0.83737422
124MP0002751_abnormal_autonomic_nervous0.80843896
125MP0001299_abnormal_eye_distance/0.80805522
126MP0005551_abnormal_eye_electrophysiolog0.80745464
127MP0005379_endocrine/exocrine_gland_phen0.79826788
128MP0003861_abnormal_nervous_system0.79819038
129MP0002269_muscular_atrophy0.78643485
130MP0006138_congestive_heart_failure0.78578623
131MP0002938_white_spotting0.78142386
132MP0003724_increased_susceptibility_to0.77915726
133MP0003698_abnormal_male_reproductive0.77469214
134MP0008057_abnormal_DNA_replication0.76604288
135MP0003755_abnormal_palate_morphology0.76201699
136MP0000049_abnormal_middle_ear0.74840062
137MP0004043_abnormal_pH_regulation0.74602139
138MP0005319_abnormal_enzyme/_coenzyme0.74329701
139MP0002092_abnormal_eye_morphology0.73470167
140MP0005408_hypopigmentation0.73412097
141MP0001835_abnormal_antigen_presentation0.71996336
142MP0001881_abnormal_mammary_gland0.71028647
143MP0002086_abnormal_extraembryonic_tissu0.67729581
144MP0003763_abnormal_thymus_physiology0.67264685
145MP0008469_abnormal_protein_level0.67098552
146MP0002095_abnormal_skin_pigmentation0.67042165
147MP0010630_abnormal_cardiac_muscle0.66777019
148MP0004381_abnormal_hair_follicle0.66199030
149MP0005499_abnormal_olfactory_system0.66180214
150MP0005394_taste/olfaction_phenotype0.66180214
151MP0005584_abnormal_enzyme/coenzyme_acti0.65621631
152MP0002277_abnormal_respiratory_mucosa0.65120277
153MP0001727_abnormal_embryo_implantation0.65025357
154MP0003385_abnormal_body_wall0.64715333
155MP0000313_abnormal_cell_death0.64412574
156MP0001542_abnormal_bone_strength0.64011348
157MP0005195_abnormal_posterior_eye0.62435362
158MP0000230_abnormal_systemic_arterial0.61552116
159MP0001663_abnormal_digestive_system0.61182019
160MP0002396_abnormal_hematopoietic_system0.60259888

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.83441923
2Mitochondrial inheritance (HP:0001427)6.43403959
3Abnormal mitochondria in muscle tissue (HP:0008316)6.39766009
4Hepatocellular necrosis (HP:0001404)6.21339240
5Hepatic necrosis (HP:0002605)5.96962229
6Acute encephalopathy (HP:0006846)5.79530943
7Increased CSF lactate (HP:0002490)5.77651696
8Progressive macrocephaly (HP:0004481)5.62266654
9Increased hepatocellular lipid droplets (HP:0006565)5.12270630
10Lipid accumulation in hepatocytes (HP:0006561)4.89644457
11Abnormality of cells of the erythroid lineage (HP:0012130)4.82450770
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.60298382
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.60298382
14Abnormal number of erythroid precursors (HP:0012131)4.47821781
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.44223573
16Cerebral edema (HP:0002181)4.37774852
17Increased intramyocellular lipid droplets (HP:0012240)4.35060005
18Increased serum lactate (HP:0002151)4.29772846
19Lactic acidosis (HP:0003128)4.18805579
20Respiratory failure (HP:0002878)4.11839771
21Reticulocytopenia (HP:0001896)4.11078615
22Increased muscle lipid content (HP:0009058)4.09884648
23Increased serum pyruvate (HP:0003542)4.06571065
24Abnormality of glycolysis (HP:0004366)4.06571065
25Exercise intolerance (HP:0003546)4.05906815
26Renal Fanconi syndrome (HP:0001994)4.01235335
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.74195620
283-Methylglutaconic aciduria (HP:0003535)3.74111805
29Macrocytic anemia (HP:0001972)3.59989985
30Exertional dyspnea (HP:0002875)3.50906748
31Chromsome breakage (HP:0040012)3.42237624
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38046769
33Respiratory difficulties (HP:0002880)3.29709758
34Optic disc pallor (HP:0000543)3.22088173
35Leukodystrophy (HP:0002415)3.12070263
36Pallor (HP:0000980)3.08536043
37Abnormality of alanine metabolism (HP:0010916)3.08390037
38Hyperalaninemia (HP:0003348)3.08390037
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08390037
40Colon cancer (HP:0003003)3.07512026
41CNS demyelination (HP:0007305)2.99851532
42Birth length less than 3rd percentile (HP:0003561)2.97079306
43Lethargy (HP:0001254)2.79092551
44Microvesicular hepatic steatosis (HP:0001414)2.75878582
45Glycosuria (HP:0003076)2.65656909
46Abnormality of urine glucose concentration (HP:0011016)2.65656909
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63007476
48Meckel diverticulum (HP:0002245)2.62016100
49Dicarboxylic aciduria (HP:0003215)2.60821384
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60821384
51Abnormality of the labia minora (HP:0012880)2.60099350
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.56888631
53Abnormality of methionine metabolism (HP:0010901)2.54622937
54Abnormal hemoglobin (HP:0011902)2.53006816
55Abnormality of renal resorption (HP:0011038)2.51729155
56Emotional lability (HP:0000712)2.51673762
57Abnormality of the ileum (HP:0001549)2.51295445
58Abnormality of chromosome stability (HP:0003220)2.46557115
59Generalized aminoaciduria (HP:0002909)2.42794699
60Ragged-red muscle fibers (HP:0003200)2.42023175
61Rhabdomyolysis (HP:0003201)2.38836051
62Multiple enchondromatosis (HP:0005701)2.38372062
63Abnormality of the preputium (HP:0100587)2.34382966
64Hyperphosphaturia (HP:0003109)2.29060640
65Palpitations (HP:0001962)2.28630582
66Oral leukoplakia (HP:0002745)2.23059684
67Nausea (HP:0002018)2.21937788
68Gliosis (HP:0002171)2.19374482
69Methylmalonic aciduria (HP:0012120)2.19267795
70Hypoplasia of the pons (HP:0012110)2.16512608
71Sudden death (HP:0001699)2.15517656
72Myoglobinuria (HP:0002913)2.11240691
73Cerebral hypomyelination (HP:0006808)2.07399922
74Muscle hypertrophy of the lower extremities (HP:0008968)2.05104757
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04800826
76Abnormality of the pons (HP:0007361)2.04063150
77Abnormal lung lobation (HP:0002101)2.02188726
78Ventricular tachycardia (HP:0004756)2.00573437
79Calf muscle hypertrophy (HP:0008981)1.99984829
80Bilateral microphthalmos (HP:0007633)1.98898672
81Type I transferrin isoform profile (HP:0003642)1.98392015
82Conjunctival hamartoma (HP:0100780)1.97026661
83Vomiting (HP:0002013)1.95457464
84Triphalangeal thumb (HP:0001199)1.94828656
85X-linked dominant inheritance (HP:0001423)1.93077023
86Small intestinal stenosis (HP:0012848)1.92910676
87Duodenal stenosis (HP:0100867)1.92910676
88Aplastic anemia (HP:0001915)1.91923784
89Lipoatrophy (HP:0100578)1.90459056
90Hyperglycinuria (HP:0003108)1.89722840
91Absent thumb (HP:0009777)1.88787945
92Pancreatic cysts (HP:0001737)1.88559245
93Neuroendocrine neoplasm (HP:0100634)1.88400630
94Methylmalonic acidemia (HP:0002912)1.87543364
95Abnormality of the carotid arteries (HP:0005344)1.87418807
96Abnormality of fatty-acid metabolism (HP:0004359)1.84866059
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84761487
98Congenital, generalized hypertrichosis (HP:0004540)1.84326631
99Abnormality of homocysteine metabolism (HP:0010919)1.82974243
100Homocystinuria (HP:0002156)1.82974243
101Progressive muscle weakness (HP:0003323)1.82343847
102Nephroblastoma (Wilms tumor) (HP:0002667)1.82090611
103Pancytopenia (HP:0001876)1.81639011
104Abnormality of sulfur amino acid metabolism (HP:0004339)1.81119034
105Aplasia/hypoplasia of the uterus (HP:0008684)1.81079401
106Abnormality of DNA repair (HP:0003254)1.80234303
107Abnormality of serum amino acid levels (HP:0003112)1.79626527
108Amniotic constriction ring (HP:0009775)1.78166515
109Abnormality of placental membranes (HP:0011409)1.78166515
110Reduced antithrombin III activity (HP:0001976)1.77539350
111Abnormality of the duodenum (HP:0002246)1.77501637
112Abnormal urine phosphate concentration (HP:0012599)1.75329441
113Sloping forehead (HP:0000340)1.74075978
114Pancreatic fibrosis (HP:0100732)1.74067851
115Abnormality of glycine metabolism (HP:0010895)1.73387458
116Abnormality of serine family amino acid metabolism (HP:0010894)1.73387458
117Esophageal neoplasm (HP:0100751)1.72693494
118Neoplasm of head and neck (HP:0012288)1.72693494
119Progressive external ophthalmoplegia (HP:0000590)1.71910964
120Hyperglycinemia (HP:0002154)1.71642338
121Blindness (HP:0000618)1.71106194
122Horseshoe kidney (HP:0000085)1.71032507
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.71031156
124Embryonal renal neoplasm (HP:0011794)1.70441924
125Hypoglycemic coma (HP:0001325)1.69689232
126Stenosis of the external auditory canal (HP:0000402)1.68593676
127Megaloblastic anemia (HP:0001889)1.66986289
128Oligodactyly (hands) (HP:0001180)1.66982179
129Testicular atrophy (HP:0000029)1.66321103
130Exercise-induced muscle cramps (HP:0003710)1.66195437
131Trismus (HP:0000211)1.65599756
132Abnormal protein glycosylation (HP:0012346)1.65489161
133Abnormal glycosylation (HP:0012345)1.65489161
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65489161
135Abnormal protein N-linked glycosylation (HP:0012347)1.65489161
136Metabolic acidosis (HP:0001942)1.64408212
137Rough bone trabeculation (HP:0100670)1.64189980
138Hyperammonemia (HP:0001987)1.63438646
139Absent radius (HP:0003974)1.62147176
140Sclerocornea (HP:0000647)1.61690095
141Proximal tubulopathy (HP:0000114)1.60656373
142Dilated cardiomyopathy (HP:0001644)1.59509111
143Bifid tongue (HP:0010297)1.59099810
144Partial agenesis of the corpus callosum (HP:0001338)1.58807421
145Renal tubular dysfunction (HP:0000124)1.58466280
146Volvulus (HP:0002580)1.58408848
147Myelodysplasia (HP:0002863)1.58193790
148Facial cleft (HP:0002006)1.58057422
149Pheochromocytoma (HP:0002666)1.57682606
150Abnormality of reticulocytes (HP:0004312)1.57587991
151Renal cortical cysts (HP:0000803)1.57262919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.68906014
2TLK14.13983720
3BUB13.75681346
4EIF2AK13.74336065
5NME13.64305481
6STK163.34464819
7VRK23.04342444
8BCKDK2.86656905
9MYLK2.38825606
10VRK12.29877553
11EIF2AK32.06822550
12TAF12.06380599
13MST42.04118425
14SRPK12.02875263
15OBSCN1.93297576
16LMTK21.88642398
17MAP3K121.88267039
18WEE11.88184180
19PBK1.88076992
20PIM21.81881539
21CHEK21.61045672
22NUAK11.51686271
23PLK41.45577240
24ILK1.41780619
25IRAK31.40881296
26PDK41.38454952
27PDK31.38454952
28PNCK1.30907805
29ZAK1.28193833
30BRSK21.27392754
31WNK31.26536704
32CDK191.23842902
33PDK21.22545701
34LIMK11.22003049
35MAP3K111.20651407
36ATR1.09967570
37BRAF1.08701201
38GRK71.07844630
39TESK21.01895866
40STK241.01728817
41NEK91.00816231
42ARAF1.00740211
43MAPKAPK50.94434580
44KDR0.94305670
45TRIM280.93233373
46NEK10.92910796
47MAP4K20.92785364
48TESK10.92130628
49ABL20.91466608
50DAPK30.91198964
51IRAK40.90777082
52AURKB0.90117279
53CASK0.90097116
54AURKA0.88353629
55NEK20.86686102
56STK38L0.85479459
57PIK3CA0.84355048
58ERBB40.83826297
59CDK70.83587840
60ATM0.82978728
61TGFBR10.81513591
62CSNK1G10.80944947
63TNIK0.79996327
64ACVR1B0.79421016
65TEC0.78872969
66MUSK0.78096529
67PLK10.76965954
68STK30.76962517
69EIF2AK20.76283698
70STK390.76263956
71CSNK1G30.76090173
72CDC70.75424498
73CHEK10.75407587
74CDK80.75138394
75MKNK10.74777865
76ALK0.74138383
77CSNK2A10.71901949
78TSSK60.71667155
79PIK3CG0.71597840
80ERBB30.70638239
81LATS10.67408036
82SCYL20.66999232
83BLK0.65703009
84PLK20.64923611
85RPS6KA40.64633072
86CSNK2A20.64540736
87CSNK1A1L0.63502631
88PASK0.63450845
89TXK0.63243958
90CSNK1E0.62889119
91WNK40.62493136
92CCNB10.62210140
93PHKG10.61330391
94PHKG20.61330391
95MAP3K40.61144250
96RPS6KA50.60387058
97MKNK20.60244312
98INSRR0.58393576
99EEF2K0.57767019
100BRSK10.56263311
101BMPR1B0.55789832
102ADRBK20.54893435
103CDK10.54300987
104RPS6KB20.52194884
105CSNK1G20.51951892
106FRK0.51865061
107PLK30.50835923
108TTN0.50679154
109DYRK30.50530612
110FLT30.50150696
111TIE10.49669856
112GRK10.49242361
113MAP2K60.46793687
114CDK20.46708479
115MAP2K70.45064747
116BCR0.44555482
117CDK30.43981654
118BMPR20.43426614
119STK40.41828028
120PINK10.41577417
121FGFR10.40993741
122LATS20.40558141
123CAMK2G0.40161738
124MAPKAPK30.39920001
125PAK10.39796569
126DYRK20.39278101
127PRKDC0.39109221
128OXSR10.38542615
129CAMK2D0.38443690
130PRKG20.37874225
131MAP3K30.35232475
132CLK10.35007363
133ZAP700.33983212
134AKT20.32921612
135IRAK20.31948079
136IRAK10.30155324
137TYK20.30105971
138MAP2K30.30012682
139LRRK20.29261863
140TTK0.29108092
141MET0.28475883
142MST1R0.28046245
143MAP4K10.26253843
144PRKCD0.25022065
145IKBKB0.24762837
146PRKACA0.24359879

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.42785215
2Oxidative phosphorylation_Homo sapiens_hsa001905.07332211
3Parkinsons disease_Homo sapiens_hsa050124.57733069
4Proteasome_Homo sapiens_hsa030503.98223069
5Huntingtons disease_Homo sapiens_hsa050163.30756473
6Alzheimers disease_Homo sapiens_hsa050103.21300787
7RNA polymerase_Homo sapiens_hsa030203.16840032
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.98666111
9Protein export_Homo sapiens_hsa030602.82373027
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50717027
11DNA replication_Homo sapiens_hsa030302.32279221
12Cardiac muscle contraction_Homo sapiens_hsa042602.26444704
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07849740
14Mismatch repair_Homo sapiens_hsa034302.03037630
15Pyrimidine metabolism_Homo sapiens_hsa002402.02456522
16Homologous recombination_Homo sapiens_hsa034401.86595051
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76816816
18Spliceosome_Homo sapiens_hsa030401.70748215
19Nucleotide excision repair_Homo sapiens_hsa034201.52362407
20Propanoate metabolism_Homo sapiens_hsa006401.44794975
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40378652
22Selenocompound metabolism_Homo sapiens_hsa004501.36471170
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33104711
24Base excision repair_Homo sapiens_hsa034101.31027064
25Carbon metabolism_Homo sapiens_hsa012001.30879809
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29403028
27RNA transport_Homo sapiens_hsa030131.23864454
28Fatty acid elongation_Homo sapiens_hsa000621.23671387
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19595648
30Folate biosynthesis_Homo sapiens_hsa007901.17301317
31Sulfur relay system_Homo sapiens_hsa041221.15847436
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15284691
33Pyruvate metabolism_Homo sapiens_hsa006201.13571690
34Purine metabolism_Homo sapiens_hsa002301.13551497
35One carbon pool by folate_Homo sapiens_hsa006701.12330142
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03695060
37Basal transcription factors_Homo sapiens_hsa030220.99990300
38RNA degradation_Homo sapiens_hsa030180.95461001
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89404398
40Metabolic pathways_Homo sapiens_hsa011000.87096785
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84722342
42Glutathione metabolism_Homo sapiens_hsa004800.84155712
43Fanconi anemia pathway_Homo sapiens_hsa034600.83022404
44Fatty acid degradation_Homo sapiens_hsa000710.81642473
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78062350
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76994521
47Non-homologous end-joining_Homo sapiens_hsa034500.76293764
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.73523723
49Sulfur metabolism_Homo sapiens_hsa009200.72008488
50Nitrogen metabolism_Homo sapiens_hsa009100.67188598
51Oocyte meiosis_Homo sapiens_hsa041140.67142856
52Biosynthesis of amino acids_Homo sapiens_hsa012300.65492575
53Pentose phosphate pathway_Homo sapiens_hsa000300.62535579
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62186157
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61775744
56Peroxisome_Homo sapiens_hsa041460.59367765
57Caffeine metabolism_Homo sapiens_hsa002320.59112515
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57635264
59Arachidonic acid metabolism_Homo sapiens_hsa005900.53546155
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52012980
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51493248
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.50486284
63Tyrosine metabolism_Homo sapiens_hsa003500.49155375
64Cell cycle_Homo sapiens_hsa041100.47592415
65Epstein-Barr virus infection_Homo sapiens_hsa051690.47328311
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46991534
67Arginine and proline metabolism_Homo sapiens_hsa003300.46971778
68Phototransduction_Homo sapiens_hsa047440.45788499
69Fatty acid metabolism_Homo sapiens_hsa012120.45497965
70Fructose and mannose metabolism_Homo sapiens_hsa000510.44022353
71Systemic lupus erythematosus_Homo sapiens_hsa053220.43647311
72Arginine biosynthesis_Homo sapiens_hsa002200.43554360
73Phenylalanine metabolism_Homo sapiens_hsa003600.43476874
74N-Glycan biosynthesis_Homo sapiens_hsa005100.42216405
75beta-Alanine metabolism_Homo sapiens_hsa004100.42075958
76Galactose metabolism_Homo sapiens_hsa000520.40217706
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.40163347
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39639715
79Vitamin digestion and absorption_Homo sapiens_hsa049770.39413742
80Vibrio cholerae infection_Homo sapiens_hsa051100.38783210
81Lysine degradation_Homo sapiens_hsa003100.38434271
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36271301
83Butanoate metabolism_Homo sapiens_hsa006500.35682702
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34782440
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33417587
86Legionellosis_Homo sapiens_hsa051340.32590495
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32466100
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.31043666
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29818703
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29348834
91Basal cell carcinoma_Homo sapiens_hsa052170.28683729
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28355692
93Hippo signaling pathway_Homo sapiens_hsa043900.27944787
94Chemical carcinogenesis_Homo sapiens_hsa052040.26995326
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26052192
96Collecting duct acid secretion_Homo sapiens_hsa049660.25979608
97TGF-beta signaling pathway_Homo sapiens_hsa043500.25667093
98Allograft rejection_Homo sapiens_hsa053300.24859188
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24501503
100p53 signaling pathway_Homo sapiens_hsa041150.23703835
101Alcoholism_Homo sapiens_hsa050340.23497771
102Fatty acid biosynthesis_Homo sapiens_hsa000610.23459187
103Regulation of autophagy_Homo sapiens_hsa041400.22316447
104Ether lipid metabolism_Homo sapiens_hsa005650.22081170
105Graft-versus-host disease_Homo sapiens_hsa053320.19558098
106Asthma_Homo sapiens_hsa053100.18110712
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.17399654
108Wnt signaling pathway_Homo sapiens_hsa043100.17292347
109mRNA surveillance pathway_Homo sapiens_hsa030150.16560916
110Nicotine addiction_Homo sapiens_hsa050330.16311706
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16100086
112Herpes simplex infection_Homo sapiens_hsa051680.15474887
113Linoleic acid metabolism_Homo sapiens_hsa005910.14688532
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.12471838
115Tryptophan metabolism_Homo sapiens_hsa003800.11828170
116Vitamin B6 metabolism_Homo sapiens_hsa007500.11453403
117Starch and sucrose metabolism_Homo sapiens_hsa005000.11243606
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11075312
119Antigen processing and presentation_Homo sapiens_hsa046120.10894436
120Fat digestion and absorption_Homo sapiens_hsa049750.09449184
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09030606
122Other glycan degradation_Homo sapiens_hsa005110.08933259
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08745570
124Steroid biosynthesis_Homo sapiens_hsa001000.08574052
125Retinol metabolism_Homo sapiens_hsa008300.08282081

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