MRPL30P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.04213927
2cullin deneddylation (GO:0010388)5.68208086
3protein deneddylation (GO:0000338)5.38920011
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14833374
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.77694996
6ATP synthesis coupled proton transport (GO:0015986)4.77694996
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.51482420
8ribosome assembly (GO:0042255)4.51257540
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.36147164
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.27571914
11NADH dehydrogenase complex assembly (GO:0010257)4.27571914
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27571914
13maturation of 5.8S rRNA (GO:0000460)4.22980309
14water-soluble vitamin biosynthetic process (GO:0042364)4.17287375
15rRNA modification (GO:0000154)4.16796371
16chaperone-mediated protein transport (GO:0072321)4.12702386
17protein complex biogenesis (GO:0070271)4.10222294
18regulation of cellular amino acid metabolic process (GO:0006521)4.07736298
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.05180322
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.03907215
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.03907215
22mitochondrial respiratory chain complex assembly (GO:0033108)3.92523783
23respiratory electron transport chain (GO:0022904)3.91049632
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89558690
25electron transport chain (GO:0022900)3.86827753
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84695700
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.78926213
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.78926213
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.78926213
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75293211
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74959142
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74959142
33DNA deamination (GO:0045006)3.74926302
34negative regulation of ligase activity (GO:0051352)3.67539232
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67539232
36metallo-sulfur cluster assembly (GO:0031163)3.64293612
37iron-sulfur cluster assembly (GO:0016226)3.64293612
38mannosylation (GO:0097502)3.61780834
39DNA damage response, detection of DNA damage (GO:0042769)3.60306466
40respiratory chain complex IV assembly (GO:0008535)3.60185476
41ribosomal large subunit biogenesis (GO:0042273)3.59688979
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59253775
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.59253775
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.55536880
45rRNA methylation (GO:0031167)3.55297597
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48393027
47deoxyribose phosphate biosynthetic process (GO:0046385)3.46271879
482-deoxyribonucleotide biosynthetic process (GO:0009265)3.46271879
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44444375
50GTP biosynthetic process (GO:0006183)3.39696151
51amino acid activation (GO:0043038)3.38082703
52tRNA aminoacylation (GO:0043039)3.38082703
53tRNA aminoacylation for protein translation (GO:0006418)3.36036280
54protein targeting to mitochondrion (GO:0006626)3.33979837
55protein neddylation (GO:0045116)3.30003856
56peptidyl-histidine modification (GO:0018202)3.28547078
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.22053451
58termination of RNA polymerase III transcription (GO:0006386)3.22053451
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20552401
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20443103
61protein localization to mitochondrion (GO:0070585)3.20134097
62preassembly of GPI anchor in ER membrane (GO:0016254)3.19726445
63mitochondrial RNA metabolic process (GO:0000959)3.19564409
64aldehyde catabolic process (GO:0046185)3.19337238
65ribosome biogenesis (GO:0042254)3.19108966
66tRNA processing (GO:0008033)3.17624687
67tRNA metabolic process (GO:0006399)3.17192123
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17148402
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16959584
70DNA catabolic process, exonucleolytic (GO:0000738)3.16880797
71protein-cofactor linkage (GO:0018065)3.14087147
72establishment of protein localization to mitochondrion (GO:0072655)3.12838979
73spliceosomal snRNP assembly (GO:0000387)3.10153550
74transcription from mitochondrial promoter (GO:0006390)3.10047658
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03684858
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.02830605
77positive regulation of ligase activity (GO:0051351)3.01748354
78DNA double-strand break processing (GO:0000729)3.01077936
79intracellular protein transmembrane import (GO:0044743)3.00622779
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99869099
81regulation of helicase activity (GO:0051095)2.99470930
82amino acid salvage (GO:0043102)2.99313606
83L-methionine salvage (GO:0071267)2.99313606
84L-methionine biosynthetic process (GO:0071265)2.99313606
85positive regulation of mitochondrial fission (GO:0090141)2.99306261
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97956263
87ribonucleoprotein complex disassembly (GO:0032988)2.97840212
88hydrogen ion transmembrane transport (GO:1902600)2.97655068
89oxidative phosphorylation (GO:0006119)2.96342209
90guanosine-containing compound biosynthetic process (GO:1901070)2.95714227
91cellular component biogenesis (GO:0044085)2.95118099
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93550665
93organelle disassembly (GO:1903008)2.93331584
94cytochrome complex assembly (GO:0017004)2.93036575
95UTP metabolic process (GO:0046051)2.92170964
96purine nucleotide salvage (GO:0032261)2.91216135
97IMP biosynthetic process (GO:0006188)2.89509912
98UTP biosynthetic process (GO:0006228)2.86660480
99DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85955114
100ATP biosynthetic process (GO:0006754)2.84775245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.54268882
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.88404032
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.45469918
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80176647
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54330560
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.38730768
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.36245240
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07558622
9VDR_23849224_ChIP-Seq_CD4+_Human3.04102603
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81256000
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.71596321
12ZNF274_21170338_ChIP-Seq_K562_Hela2.61418462
13ELK1_19687146_ChIP-ChIP_HELA_Human2.53806581
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51999472
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.41377671
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39988280
17FOXP3_21729870_ChIP-Seq_TREG_Human2.31739461
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27461434
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23459132
20DCP1A_22483619_ChIP-Seq_HELA_Human2.19962775
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12080899
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08939650
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05411137
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02791515
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01052844
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.99498849
27GABP_19822575_ChIP-Seq_HepG2_Human1.97949509
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95604122
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87336615
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86966238
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86951777
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83624275
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76950576
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.75464247
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74372216
36TTF2_22483619_ChIP-Seq_HELA_Human1.66530912
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65698655
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65402520
39VDR_22108803_ChIP-Seq_LS180_Human1.64793420
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64622695
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62704557
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56994687
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.55316612
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.52493326
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52200795
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48344231
47MYC_18940864_ChIP-ChIP_HL60_Human1.47639646
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45976454
49EWS_26573619_Chip-Seq_HEK293_Human1.45666854
50XRN2_22483619_ChIP-Seq_HELA_Human1.45484348
51TP53_22573176_ChIP-Seq_HFKS_Human1.41896360
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36378810
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35492115
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30553762
55IGF1R_20145208_ChIP-Seq_DFB_Human1.29886724
56FUS_26573619_Chip-Seq_HEK293_Human1.29736995
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25659828
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17742532
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15634293
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14919704
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11664950
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11085171
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08427712
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08175673
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07848372
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07470483
67P300_19829295_ChIP-Seq_ESCs_Human1.05936741
68E2F7_22180533_ChIP-Seq_HELA_Human1.04982923
69AR_20517297_ChIP-Seq_VCAP_Human1.03672187
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.02810095
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02810095
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02783952
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02739226
74KDM5A_27292631_Chip-Seq_BREAST_Human1.01099769
75TAF15_26573619_Chip-Seq_HEK293_Human0.98446310
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97096473
77CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96508095
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96123895
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95406266
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93585680
81GBX2_23144817_ChIP-Seq_PC3_Human0.93447076
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92647622
83IRF1_19129219_ChIP-ChIP_H3396_Human0.92599665
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91441357
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.91188292
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.87061465
87SOX2_19829295_ChIP-Seq_ESCs_Human0.85331268
88NANOG_19829295_ChIP-Seq_ESCs_Human0.85331268
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84601394
90CIITA_25753668_ChIP-Seq_RAJI_Human0.84477527
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84135394
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83730162
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.81907227
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80575923
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80558532
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.80136385
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78120604
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77979336
99CBP_20019798_ChIP-Seq_JUKART_Human0.77979336
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76236989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.69411809
2MP0002102_abnormal_ear_morphology3.08480696
3MP0008058_abnormal_DNA_repair2.96835127
4MP0006036_abnormal_mitochondrial_physio2.83208104
5MP0001984_abnormal_olfaction2.80774627
6MP0006072_abnormal_retinal_apoptosis2.76763473
7MP0001529_abnormal_vocalization2.54256786
8MP0003880_abnormal_central_pattern2.43631939
9MP0002837_dystrophic_cardiac_calcinosis2.28136415
10MP0008877_abnormal_DNA_methylation2.24146627
11MP0001764_abnormal_homeostasis2.19663777
12MP0006035_abnormal_mitochondrial_morpho2.17787547
13MP0004957_abnormal_blastocyst_morpholog2.14452604
14MP0003786_premature_aging2.05017517
15MP0004147_increased_porphyrin_level2.01696690
16MP0005075_abnormal_melanosome_morpholog2.01349182
17MP0010094_abnormal_chromosome_stability1.94763472
18MP0003693_abnormal_embryo_hatching1.93932898
19MP0003195_calcinosis1.92250856
20MP0008995_early_reproductive_senescence1.88527915
21MP0008872_abnormal_physiological_respon1.86756588
22MP0003186_abnormal_redox_activity1.84779435
23MP0005253_abnormal_eye_physiology1.83478533
24MP0009697_abnormal_copulation1.73114980
25MP0003718_maternal_effect1.72546286
26MP0005551_abnormal_eye_electrophysiolog1.70854021
27MP0006276_abnormal_autonomic_nervous1.69563224
28MP0008789_abnormal_olfactory_epithelium1.69414104
29MP0005084_abnormal_gallbladder_morpholo1.68564081
30MP0003011_delayed_dark_adaptation1.68238992
31MP0008057_abnormal_DNA_replication1.65823737
32MP0002638_abnormal_pupillary_reflex1.64894852
33MP0005646_abnormal_pituitary_gland1.57908313
34MP0005167_abnormal_blood-brain_barrier1.54076294
35MP0002163_abnormal_gland_morphology1.50939688
36MP0000372_irregular_coat_pigmentation1.48085636
37MP0009046_muscle_twitch1.47838252
38MP0002736_abnormal_nociception_after1.45761529
39MP0005379_endocrine/exocrine_gland_phen1.42618117
40MP0003111_abnormal_nucleus_morphology1.37877022
41MP0008932_abnormal_embryonic_tissue1.35698308
42MP0004133_heterotaxia1.33462147
43MP0005499_abnormal_olfactory_system1.33216462
44MP0005394_taste/olfaction_phenotype1.33216462
45MP0010386_abnormal_urinary_bladder1.32376280
46MP0003077_abnormal_cell_cycle1.26501082
47MP0005645_abnormal_hypothalamus_physiol1.23529335
48MP0002751_abnormal_autonomic_nervous1.23321579
49MP0001986_abnormal_taste_sensitivity1.16943786
50MP0002090_abnormal_vision1.15402174
51MP0000358_abnormal_cell_content/1.14670576
52MP0001968_abnormal_touch/_nociception1.11819232
53MP0002938_white_spotting1.11067483
54MP0008875_abnormal_xenobiotic_pharmacok1.10053950
55MP0004142_abnormal_muscle_tone1.07085836
56MP0005266_abnormal_metabolism1.05108252
57MP0005332_abnormal_amino_acid1.04119114
58MP0002234_abnormal_pharynx_morphology1.03155808
59MP0001293_anophthalmia1.02776118
60MP0003646_muscle_fatigue1.01917239
61MP0000749_muscle_degeneration1.01370120
62MP0003787_abnormal_imprinting1.01117582
63MP0002272_abnormal_nervous_system1.00626787
64MP0000631_abnormal_neuroendocrine_gland0.96555498
65MP0001501_abnormal_sleep_pattern0.96371341
66MP0005671_abnormal_response_to0.94242920
67MP0006292_abnormal_olfactory_placode0.92791516
68MP0001905_abnormal_dopamine_level0.92485418
69MP0004215_abnormal_myocardial_fiber0.90741296
70MP0004782_abnormal_surfactant_physiolog0.85614900
71MP0009745_abnormal_behavioral_response0.85413122
72MP0008007_abnormal_cellular_replicative0.83222435
73MP0001929_abnormal_gametogenesis0.81078202
74MP0001485_abnormal_pinna_reflex0.80359137
75MP0005408_hypopigmentation0.78822686
76MP0008873_increased_physiological_sensi0.78538197
77MP0010368_abnormal_lymphatic_system0.75858149
78MP0005636_abnormal_mineral_homeostasis0.74933747
79MP0005389_reproductive_system_phenotype0.74773152
80MP0002332_abnormal_exercise_endurance0.74588927
81MP0002735_abnormal_chemical_nociception0.73755871
82MP0002572_abnormal_emotion/affect_behav0.73673910
83MP0005647_abnormal_sex_gland0.73422917
84MP0001486_abnormal_startle_reflex0.72512837
85MP0002909_abnormal_adrenal_gland0.71942996
86MP0005376_homeostasis/metabolism_phenot0.70652483
87MP0004885_abnormal_endolymph0.70487029
88MP0005330_cardiomyopathy0.70395477
89MP0002210_abnormal_sex_determination0.69852498
90MP0005391_vision/eye_phenotype0.69779995
91MP0009764_decreased_sensitivity_to0.69470064
92MP0005410_abnormal_fertilization0.68377095
93MP0004145_abnormal_muscle_electrophysio0.66935766
94MP0003866_abnormal_defecation0.66516733
95MP0002069_abnormal_eating/drinking_beha0.65137823
96MP0002132_abnormal_respiratory_system0.64909234
97MP0002229_neurodegeneration0.62864991
98MP0005195_abnormal_posterior_eye0.62266711
99MP0003567_abnormal_fetal_cardiomyocyte0.62185224
100MP0002752_abnormal_somatic_nervous0.61388209

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.74756216
2Abnormal mitochondria in muscle tissue (HP:0008316)4.45902142
3Mitochondrial inheritance (HP:0001427)4.34337862
4Acute encephalopathy (HP:0006846)4.33945312
5Hepatocellular necrosis (HP:0001404)4.23670982
6Increased CSF lactate (HP:0002490)4.19974436
7Progressive macrocephaly (HP:0004481)4.12369595
8Hepatic necrosis (HP:0002605)3.98877214
9Abnormality of the labia minora (HP:0012880)3.71124696
10Type I transferrin isoform profile (HP:0003642)3.48499331
11Cerebral edema (HP:0002181)3.42617373
12Increased serum lactate (HP:0002151)3.38981262
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.32992131
14Abnormality of alanine metabolism (HP:0010916)3.32992131
15Hyperalaninemia (HP:0003348)3.32992131
16Lipid accumulation in hepatocytes (HP:0006561)3.32701985
17Increased hepatocellular lipid droplets (HP:0006565)3.30709128
183-Methylglutaconic aciduria (HP:0003535)3.30222676
19Methylmalonic acidemia (HP:0002912)3.27668294
20Abnormality of methionine metabolism (HP:0010901)3.21160648
21Increased serum pyruvate (HP:0003542)3.17200546
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11101567
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11101567
24Pancreatic cysts (HP:0001737)3.09560295
25Lactic acidosis (HP:0003128)3.03292065
26Increased intramyocellular lipid droplets (HP:0012240)3.01885650
27Abnormality of glycolysis (HP:0004366)2.98720561
28Medial flaring of the eyebrow (HP:0010747)2.87215388
29Aplastic anemia (HP:0001915)2.85616883
30Renal Fanconi syndrome (HP:0001994)2.81582479
31Abnormality of midbrain morphology (HP:0002418)2.80974913
32Molar tooth sign on MRI (HP:0002419)2.80974913
33Abnormal protein glycosylation (HP:0012346)2.79360120
34Abnormal glycosylation (HP:0012345)2.79360120
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79360120
36Abnormal protein N-linked glycosylation (HP:0012347)2.79360120
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.77033613
38Neonatal respiratory distress (HP:0002643)2.75896371
39Respiratory failure (HP:0002878)2.72941614
40True hermaphroditism (HP:0010459)2.72930330
41Methylmalonic aciduria (HP:0012120)2.70481481
42Abnormality of serum amino acid levels (HP:0003112)2.63018239
43Increased muscle lipid content (HP:0009058)2.60926845
44Abnormality of the anterior horn cell (HP:0006802)2.59832621
45Degeneration of anterior horn cells (HP:0002398)2.59832621
46Exercise intolerance (HP:0003546)2.54643421
47Pancreatic fibrosis (HP:0100732)2.54018672
48Congenital primary aphakia (HP:0007707)2.44016118
49Nephrogenic diabetes insipidus (HP:0009806)2.41517173
50Lethargy (HP:0001254)2.39299273
51CNS demyelination (HP:0007305)2.38025799
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35326262
53Optic disc pallor (HP:0000543)2.34708555
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.31835098
55Gait imbalance (HP:0002141)2.31048318
56Hyperglycinemia (HP:0002154)2.28120064
57Posterior subcapsular cataract (HP:0007787)2.25071256
58Microvesicular hepatic steatosis (HP:0001414)2.23196582
59Bile duct proliferation (HP:0001408)2.17976218
60Abnormal biliary tract physiology (HP:0012439)2.17976218
61Hyperglycinuria (HP:0003108)2.13363551
62Abolished electroretinogram (ERG) (HP:0000550)2.13171597
63Exertional dyspnea (HP:0002875)2.11786454
64Leukodystrophy (HP:0002415)2.10062489
65Emotional lability (HP:0000712)2.06184488
66Abnormality of serine family amino acid metabolism (HP:0010894)2.05122679
67Abnormality of glycine metabolism (HP:0010895)2.05122679
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03832278
69Generalized aminoaciduria (HP:0002909)2.03565641
70Congenital, generalized hypertrichosis (HP:0004540)2.01784316
71Ketoacidosis (HP:0001993)2.00793109
72Neoplasm of the adrenal gland (HP:0100631)1.98100981
73Retinal dysplasia (HP:0007973)1.95610666
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.95132839
75Oral leukoplakia (HP:0002745)1.91101511
76Palpitations (HP:0001962)1.88363977
77Gonadotropin excess (HP:0000837)1.87623012
78Pancytopenia (HP:0001876)1.87589277
79Abnormality of urine glucose concentration (HP:0011016)1.87415998
80Glycosuria (HP:0003076)1.87415998
81Abnormality of vitamin B metabolism (HP:0004340)1.86907442
82Cerebral hypomyelination (HP:0006808)1.85372678
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83680606
84Type II lissencephaly (HP:0007260)1.79562256
85IgM deficiency (HP:0002850)1.79049476
86Dicarboxylic aciduria (HP:0003215)1.78233698
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78233698
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.77953851
89Genital tract atresia (HP:0001827)1.77838489
90Hypomagnesemia (HP:0002917)1.77448053
91Vaginal atresia (HP:0000148)1.73010769
92Cystic liver disease (HP:0006706)1.71835489
93Brushfield spots (HP:0001088)1.69956890
94Nephronophthisis (HP:0000090)1.69454184
95Ketosis (HP:0001946)1.67390659
96Abnormality of renal resorption (HP:0011038)1.66740139
97Chronic hepatic failure (HP:0100626)1.65940314
98Hypothermia (HP:0002045)1.65797224
99CNS hypomyelination (HP:0003429)1.65442693
100Sensorimotor neuropathy (HP:0007141)1.64948011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.37290170
2TIE13.91527629
3STK163.25325366
4VRK23.16324077
5SRPK13.15051035
6TRIM283.00077789
7EIF2AK32.89921890
8EIF2AK12.66613715
9PBK2.51366399
10MST42.31589867
11MAP4K22.29814133
12ZAK2.05057643
13PDK22.00205245
14PLK31.99688133
15BCKDK1.81478784
16GRK11.73752402
17MAP3K121.71054297
18BMPR1B1.70655398
19FRK1.65684368
20VRK11.60622525
21NEK11.59440121
22BUB11.48636820
23CDC71.39607117
24TEC1.34507614
25NME11.33955910
26WNK31.32388094
27CDK191.31061362
28NUAK11.30398098
29CSNK1G31.28554279
30DAPK11.28346968
31MKNK11.11579897
32MAPKAPK51.08512397
33CSNK1A1L1.07964791
34ADRBK21.06939531
35CSNK1G11.03680036
36BMPR21.00252181
37ERBB30.98694962
38MAP2K70.95438616
39TNIK0.95238057
40LIMK10.94540051
41PASK0.94207800
42MKNK20.92124276
43CSNK1G20.91166379
44MAP3K40.90788022
45OXSR10.90315767
46SCYL20.89638309
47KDR0.88604159
48BCR0.87615980
49CDK80.86750481
50CASK0.84109153
51TESK10.82767954
52ALK0.82712463
53ATR0.82136044
54PLK10.81722573
55DYRK20.81678054
56NME20.77094721
57TLK10.76892842
58TAOK30.75297101
59EPHA40.75290310
60PHKG20.73254213
61PHKG10.73254213
62PLK20.70854039
63TTK0.63906889
64AURKB0.61573641
65INSRR0.60363115
66PLK40.60006889
67SIK30.59606354
68TESK20.59597128
69TGFBR10.56995803
70ACVR1B0.50400573
71WNK40.50005867
72ERBB40.49585877
73FGFR20.48102001
74MAPKAPK30.46796022
75CSNK2A10.45824549
76PIM20.45660769
77CSNK2A20.45366505
78CCNB10.44543997
79ATM0.44107015
80MYLK0.44027453
81FER0.40272773
82PINK10.39974861
83RPS6KA50.37387383
84MAPK130.36064058
85CAMK2A0.34600858
86ITK0.34353147
87EIF2AK20.33654415
88ARAF0.33058395
89RPS6KA40.31848878
90TAF10.31307725
91DAPK30.30495307
92AURKA0.30491874
93CDK90.29785679
94MAP3K50.29330724
95PAK40.28519981
96PAK30.27719763
97DYRK30.27633748
98STK38L0.26738915
99CSNK1E0.26264691
100DAPK20.26063898

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.55471500
2Oxidative phosphorylation_Homo sapiens_hsa001903.78404550
3Protein export_Homo sapiens_hsa030603.39564193
4Parkinsons disease_Homo sapiens_hsa050123.18307979
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62889352
6RNA polymerase_Homo sapiens_hsa030202.43088314
7Huntingtons disease_Homo sapiens_hsa050162.25366370
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21691421
9Sulfur metabolism_Homo sapiens_hsa009202.12503079
10Ribosome_Homo sapiens_hsa030102.10649053
11Alzheimers disease_Homo sapiens_hsa050102.01522529
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98730083
13One carbon pool by folate_Homo sapiens_hsa006701.94726654
14Basal transcription factors_Homo sapiens_hsa030221.94520125
15Propanoate metabolism_Homo sapiens_hsa006401.94208860
16Spliceosome_Homo sapiens_hsa030401.91862105
17DNA replication_Homo sapiens_hsa030301.80633478
18Non-homologous end-joining_Homo sapiens_hsa034501.75301061
19Mismatch repair_Homo sapiens_hsa034301.74286308
20RNA degradation_Homo sapiens_hsa030181.68739897
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68477184
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66346299
23Fatty acid elongation_Homo sapiens_hsa000621.62699824
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59917946
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57737938
26RNA transport_Homo sapiens_hsa030131.52007703
27Nucleotide excision repair_Homo sapiens_hsa034201.50550352
28Base excision repair_Homo sapiens_hsa034101.47417055
29Butanoate metabolism_Homo sapiens_hsa006501.44520541
30Pyrimidine metabolism_Homo sapiens_hsa002401.44304812
31Pyruvate metabolism_Homo sapiens_hsa006201.44144027
32Homologous recombination_Homo sapiens_hsa034401.41473460
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38260608
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.36161707
35Collecting duct acid secretion_Homo sapiens_hsa049661.29900080
36Sulfur relay system_Homo sapiens_hsa041221.27710948
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25175420
38Purine metabolism_Homo sapiens_hsa002301.18925901
39Cardiac muscle contraction_Homo sapiens_hsa042601.15594165
40Tryptophan metabolism_Homo sapiens_hsa003801.13923854
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07706192
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06946450
43Regulation of autophagy_Homo sapiens_hsa041401.04060244
44Glutathione metabolism_Homo sapiens_hsa004801.02694984
45Peroxisome_Homo sapiens_hsa041460.99651212
46Phototransduction_Homo sapiens_hsa047440.99199896
47Carbon metabolism_Homo sapiens_hsa012000.98249359
48Caffeine metabolism_Homo sapiens_hsa002320.97599054
49Fanconi anemia pathway_Homo sapiens_hsa034600.96440010
50Folate biosynthesis_Homo sapiens_hsa007900.92179584
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91434447
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89781512
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.88329255
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86486145
55Metabolic pathways_Homo sapiens_hsa011000.85461978
56beta-Alanine metabolism_Homo sapiens_hsa004100.84448510
57Selenocompound metabolism_Homo sapiens_hsa004500.83060946
58Chemical carcinogenesis_Homo sapiens_hsa052040.81164598
59Biosynthesis of amino acids_Homo sapiens_hsa012300.80839607
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77939338
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75850207
62Fatty acid degradation_Homo sapiens_hsa000710.69485251
63Steroid biosynthesis_Homo sapiens_hsa001000.68846305
64Primary immunodeficiency_Homo sapiens_hsa053400.68266864
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65916168
66N-Glycan biosynthesis_Homo sapiens_hsa005100.65851565
67Vibrio cholerae infection_Homo sapiens_hsa051100.65088621
68Fatty acid metabolism_Homo sapiens_hsa012120.64917972
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60515633
70Type I diabetes mellitus_Homo sapiens_hsa049400.56073364
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52347061
72Linoleic acid metabolism_Homo sapiens_hsa005910.51971426
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50615904
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47664458
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47623394
76Nitrogen metabolism_Homo sapiens_hsa009100.43272757
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.41462885
78Retinol metabolism_Homo sapiens_hsa008300.40431605
79Rheumatoid arthritis_Homo sapiens_hsa053230.39603023
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38149177
81Arginine and proline metabolism_Homo sapiens_hsa003300.37906058
82Nicotine addiction_Homo sapiens_hsa050330.37889671
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36644071
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34837237
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34382285
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31334873
87Cell cycle_Homo sapiens_hsa041100.31060351
88Ether lipid metabolism_Homo sapiens_hsa005650.29496464
89Synaptic vesicle cycle_Homo sapiens_hsa047210.28988517
90Fat digestion and absorption_Homo sapiens_hsa049750.27564061
91Pentose phosphate pathway_Homo sapiens_hsa000300.26599035
92p53 signaling pathway_Homo sapiens_hsa041150.26310057
93Galactose metabolism_Homo sapiens_hsa000520.25108390
94Arachidonic acid metabolism_Homo sapiens_hsa005900.24870914
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23983773
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.23870075
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23629806
98Legionellosis_Homo sapiens_hsa051340.23241479
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22689662
100Oocyte meiosis_Homo sapiens_hsa041140.22315093

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