MRPL32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.89831799
2ribosomal small subunit biogenesis (GO:0042274)5.89390238
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72825938
4ATP synthesis coupled proton transport (GO:0015986)5.43720314
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.43720314
6viral transcription (GO:0019083)5.38400717
7translational termination (GO:0006415)5.24948036
8proteasome assembly (GO:0043248)5.02909149
9maturation of SSU-rRNA (GO:0030490)4.99479588
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.92009819
11cotranslational protein targeting to membrane (GO:0006613)4.90748594
12protein targeting to ER (GO:0045047)4.82754209
13ribosomal large subunit biogenesis (GO:0042273)4.76085709
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.65741386
15protein localization to endoplasmic reticulum (GO:0070972)4.61507946
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.58036447
17translational elongation (GO:0006414)4.47904671
18respiratory electron transport chain (GO:0022904)4.39557029
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38694008
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.38694008
21NADH dehydrogenase complex assembly (GO:0010257)4.38694008
22protein complex biogenesis (GO:0070271)4.33183173
23electron transport chain (GO:0022900)4.29665769
24termination of RNA polymerase III transcription (GO:0006386)4.22980353
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.22980353
26chaperone-mediated protein transport (GO:0072321)4.21684878
27cellular protein complex disassembly (GO:0043624)4.16666798
28viral life cycle (GO:0019058)4.14647017
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.13910187
30translational initiation (GO:0006413)4.09135575
31mitochondrial respiratory chain complex assembly (GO:0033108)4.05500806
32* translation (GO:0006412)4.05476505
33protein neddylation (GO:0045116)4.03644456
34protein deneddylation (GO:0000338)4.03064641
35cullin deneddylation (GO:0010388)4.01823069
36regulation of mitochondrial translation (GO:0070129)3.99535670
37regulation of cellular amino acid metabolic process (GO:0006521)3.97570377
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.93220766
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92610180
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88719953
41DNA deamination (GO:0045006)3.86548553
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85561234
437-methylguanosine mRNA capping (GO:0006370)3.83423769
447-methylguanosine RNA capping (GO:0009452)3.81307755
45RNA capping (GO:0036260)3.81307755
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.79127180
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.79127180
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77891820
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75881974
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75881974
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75881974
52negative regulation of ligase activity (GO:0051352)3.75229068
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75229068
54rRNA modification (GO:0000154)3.75205684
55ribonucleoprotein complex biogenesis (GO:0022613)3.75205050
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.75133490
57DNA damage response, detection of DNA damage (GO:0042769)3.70424255
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66681440
59cellular component biogenesis (GO:0044085)3.63908583
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62014007
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.62014007
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.58455926
63respiratory chain complex IV assembly (GO:0008535)3.56766043
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.55202599
65purine nucleobase biosynthetic process (GO:0009113)3.52421423
66oxidative phosphorylation (GO:0006119)3.46904713
67regulation of ubiquitin-protein transferase activity (GO:0051438)3.44560471
68protein complex disassembly (GO:0043241)3.44374914
69GTP biosynthetic process (GO:0006183)3.42352184
70protein targeting to mitochondrion (GO:0006626)3.36455385
71regulation of ligase activity (GO:0051340)3.32556950
72histone exchange (GO:0043486)3.31814803
73rRNA processing (GO:0006364)3.31282322
74nucleobase biosynthetic process (GO:0046112)3.31117684
75macromolecular complex disassembly (GO:0032984)3.30846836
76CENP-A containing nucleosome assembly (GO:0034080)3.30352589
77cytochrome complex assembly (GO:0017004)3.29848661
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29552192
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28707772
80DNA double-strand break processing (GO:0000729)3.27697269
81DNA replication checkpoint (GO:0000076)3.26971040
82establishment of protein localization to mitochondrion (GO:0072655)3.25584363
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24934259
84rRNA methylation (GO:0031167)3.24030362
85positive regulation of ligase activity (GO:0051351)3.21815287
86transcription elongation from RNA polymerase I promoter (GO:0006362)3.21582357
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19529580
88regulation of mitotic spindle checkpoint (GO:1903504)3.19529580
89telomere maintenance via semi-conservative replication (GO:0032201)3.17877000
90maturation of 5.8S rRNA (GO:0000460)3.17128728
91rRNA metabolic process (GO:0016072)3.16479227
92mitotic metaphase plate congression (GO:0007080)3.15210038
93protein targeting to membrane (GO:0006612)3.12641259
94histone mRNA metabolic process (GO:0008334)3.12477730
95establishment of viral latency (GO:0019043)3.12113294
96termination of RNA polymerase I transcription (GO:0006363)3.10510662
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10372288
98chromatin remodeling at centromere (GO:0031055)3.09910707
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09420591
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09420591
101negative regulation of protein ubiquitination (GO:0031397)3.09308558
102DNA strand elongation involved in DNA replication (GO:0006271)3.07933228
103formation of translation preinitiation complex (GO:0001731)3.06846441
104nuclear-transcribed mRNA catabolic process (GO:0000956)3.06552730
105metaphase plate congression (GO:0051310)3.06354192
106iron-sulfur cluster assembly (GO:0016226)3.06154257
107metallo-sulfur cluster assembly (GO:0031163)3.06154257
108guanosine-containing compound biosynthetic process (GO:1901070)3.05274560
109ribosome assembly (GO:0042255)3.04584346
110kinetochore assembly (GO:0051382)3.03847568
111regulation of helicase activity (GO:0051095)3.03073157
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02839132
113water-soluble vitamin biosynthetic process (GO:0042364)3.02493989
114transcription-coupled nucleotide-excision repair (GO:0006283)3.02302957
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01674624
116spliceosomal snRNP assembly (GO:0000387)3.01590397
117establishment of integrated proviral latency (GO:0075713)3.01001330
118regulation of cellular amine metabolic process (GO:0033238)3.00350347
119protein localization to mitochondrion (GO:0070585)2.99653762
120pseudouridine synthesis (GO:0001522)2.98837295
121DNA replication-independent nucleosome assembly (GO:0006336)2.97873767
122DNA replication-independent nucleosome organization (GO:0034724)2.97873767
123DNA catabolic process, exonucleolytic (GO:0000738)2.97748952
124peptidyl-histidine modification (GO:0018202)2.97233010
125mRNA catabolic process (GO:0006402)2.96274497
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96035700
127inner mitochondrial membrane organization (GO:0007007)2.94754391
128IMP biosynthetic process (GO:0006188)2.94638490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01467639
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.74090139
3* EST1_17652178_ChIP-ChIP_JURKAT_Human4.35945335
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.35666774
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.03737769
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.95851765
7E2F7_22180533_ChIP-Seq_HELA_Human3.52041051
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.51104171
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49999133
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.46329737
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25389663
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21698943
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19170161
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.08652422
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99934631
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99235488
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91121492
18VDR_23849224_ChIP-Seq_CD4+_Human2.77718844
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76021070
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59422185
21ELK1_19687146_ChIP-ChIP_HELA_Human2.52463828
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.52052224
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.47632006
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40140987
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39277165
26FOXP3_21729870_ChIP-Seq_TREG_Human2.32621013
27* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28128744
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22414135
29XRN2_22483619_ChIP-Seq_HELA_Human2.19612826
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14409859
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07931242
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03444019
33TTF2_22483619_ChIP-Seq_HELA_Human1.97710001
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.95250444
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94795168
36* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93453634
37GABP_19822575_ChIP-Seq_HepG2_Human1.91448906
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86866092
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85584965
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77676562
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76898182
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66921190
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65353018
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.54093183
45* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53412329
46MYC_18940864_ChIP-ChIP_HL60_Human1.50995997
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.50140904
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48340763
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48136646
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47747009
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44543086
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42712010
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41595458
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38159765
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37862533
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36903428
57VDR_22108803_ChIP-Seq_LS180_Human1.36355279
58* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29341980
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29318320
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26840465
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26273699
62IRF1_19129219_ChIP-ChIP_H3396_Human1.23067198
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21734318
64ZNF274_21170338_ChIP-Seq_K562_Hela1.21437283
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.21385598
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.17442062
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16168722
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14515656
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14077251
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.12035395
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11024761
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09725799
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.08352997
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06168066
75AR_21909140_ChIP-Seq_LNCAP_Human1.03089037
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02640436
77FLI1_27457419_Chip-Seq_LIVER_Mouse0.98342264
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96414403
79SPI1_23547873_ChIP-Seq_NB4_Human0.95080994
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95010413
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.94271284
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93905426
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92738581
84FUS_26573619_Chip-Seq_HEK293_Human0.92243702
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.90239550
86RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88098837
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86974037
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.86852811
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84262970
90EWS_26573619_Chip-Seq_HEK293_Human0.84226855
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83869531
92IGF1R_20145208_ChIP-Seq_DFB_Human0.83454809
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83269015
94* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81363080
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81013104
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79503137
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77447416
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.75906209
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75878416
100TP53_22573176_ChIP-Seq_HFKS_Human0.75452500
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75095000
102ELF5_23300383_ChIP-Seq_T47D_Human0.74671825
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74229900
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73862859
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73536208
106CIITA_25753668_ChIP-Seq_RAJI_Human0.72174660
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71842250
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71576089
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71198199
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70176650
111KDM5A_27292631_Chip-Seq_BREAST_Human0.69824265
112P300_19829295_ChIP-Seq_ESCs_Human0.69790177
113* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69681341
114FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69512325
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.69512325
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69289811
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.69212121
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69128821
119TFEB_21752829_ChIP-Seq_HELA_Human0.67811102
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.67224518
121* SALL4_22934838_ChIP-ChIP_CD34+_Human0.65596940
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65473403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.93549905
2MP0003693_abnormal_embryo_hatching4.27536796
3MP0008057_abnormal_DNA_replication3.11973213
4MP0003941_abnormal_skin_development2.83410628
5MP0004957_abnormal_blastocyst_morpholog2.80180840
6MP0003718_maternal_effect2.78004795
7MP0001529_abnormal_vocalization2.72318966
8MP0008058_abnormal_DNA_repair2.64933321
9MP0010094_abnormal_chromosome_stability2.57865705
10MP0003186_abnormal_redox_activity2.51748242
11MP0002638_abnormal_pupillary_reflex2.49141589
12MP0003077_abnormal_cell_cycle2.41749934
13MP0002102_abnormal_ear_morphology2.37518363
14MP0001905_abnormal_dopamine_level2.24306111
15MP0003806_abnormal_nucleotide_metabolis2.14273681
16MP0005075_abnormal_melanosome_morpholog2.13442542
17MP0006036_abnormal_mitochondrial_physio2.09636070
18MP0002148_abnormal_hypersensitivity_rea2.02488376
19MP0003786_premature_aging2.02143235
20MP0009697_abnormal_copulation1.98794564
21MP0003136_yellow_coat_color1.96678453
22MP0009785_altered_susceptibility_to1.95591336
23MP0008932_abnormal_embryonic_tissue1.94966437
24MP0006292_abnormal_olfactory_placode1.89192672
25MP0000015_abnormal_ear_pigmentation1.88973515
26MP0008007_abnormal_cellular_replicative1.85969604
27MP0004381_abnormal_hair_follicle1.85470051
28MP0006072_abnormal_retinal_apoptosis1.84680570
29MP0001293_anophthalmia1.82881129
30MP0003890_abnormal_embryonic-extraembry1.78603777
31MP0005174_abnormal_tail_pigmentation1.77722934
32MP0003111_abnormal_nucleus_morphology1.74593164
33MP0000372_irregular_coat_pigmentation1.74454830
34MP0002837_dystrophic_cardiac_calcinosis1.73361958
35MP0005671_abnormal_response_to1.70419689
36MP0003656_abnormal_erythrocyte_physiolo1.69430653
37MP0006035_abnormal_mitochondrial_morpho1.69031103
38MP0005408_hypopigmentation1.68894479
39MP0008995_early_reproductive_senescence1.64031513
40MP0001188_hyperpigmentation1.61806254
41MP0001853_heart_inflammation1.59130867
42MP0003646_muscle_fatigue1.56379507
43MP0009333_abnormal_splenocyte_physiolog1.55745547
44MP0001764_abnormal_homeostasis1.52480237
45MP0003567_abnormal_fetal_cardiomyocyte1.50450914
46MP0001986_abnormal_taste_sensitivity1.44345007
47MP0001835_abnormal_antigen_presentation1.43474025
48MP0003121_genomic_imprinting1.40002559
49MP0002095_abnormal_skin_pigmentation1.38729650
50MP0010030_abnormal_orbit_morphology1.36464268
51MP0003724_increased_susceptibility_to1.33445735
52MP0002163_abnormal_gland_morphology1.32991532
53MP0010386_abnormal_urinary_bladder1.27385647
54MP0003123_paternal_imprinting1.27342653
55MP0002938_white_spotting1.26397381
56MP0005499_abnormal_olfactory_system1.25661420
57MP0005394_taste/olfaction_phenotype1.25661420
58MP0003763_abnormal_thymus_physiology1.22955239
59MP0003787_abnormal_imprinting1.22941501
60MP0006276_abnormal_autonomic_nervous1.21964650
61MP0008875_abnormal_xenobiotic_pharmacok1.20959061
62MP0002254_reproductive_system_inflammat1.20890564
63MP0002396_abnormal_hematopoietic_system1.20411432
64MP0005000_abnormal_immune_tolerance1.19856445
65MP0001730_embryonic_growth_arrest1.16458063
66MP0004147_increased_porphyrin_level1.15653199
67MP0005025_abnormal_response_to1.14410613
68MP0001697_abnormal_embryo_size1.12977703
69MP0000350_abnormal_cell_proliferation1.12649502
70MP0002132_abnormal_respiratory_system1.08544209
71MP0003937_abnormal_limbs/digits/tail_de1.07349923
72MP0002233_abnormal_nose_morphology1.06939100
73MP0004215_abnormal_myocardial_fiber1.06748618
74MP0008872_abnormal_physiological_respon1.05691388
75MP0005171_absent_coat_pigmentation1.05537700
76MP0003195_calcinosis1.02382546
77MP0008789_abnormal_olfactory_epithelium1.00461454
78MP0003880_abnormal_central_pattern0.98432198
79MP0003436_decreased_susceptibility_to0.97236780
80MP0004142_abnormal_muscle_tone0.96786849
81MP0003011_delayed_dark_adaptation0.96553656
82MP0002420_abnormal_adaptive_immunity0.96376951
83MP0001929_abnormal_gametogenesis0.95620598
84MP0002876_abnormal_thyroid_physiology0.95587448
85MP0002723_abnormal_immune_serum0.95471658
86MP0008260_abnormal_autophagy0.95445665
87MP0000490_abnormal_crypts_of0.95388270
88MP0000647_abnormal_sebaceous_gland0.95272125
89MP0008877_abnormal_DNA_methylation0.94926022
90MP0001819_abnormal_immune_cell0.94262321
91MP0005636_abnormal_mineral_homeostasis0.94231071
92MP0005379_endocrine/exocrine_gland_phen0.92589113
93MP0001145_abnormal_male_reproductive0.91493345
94MP0002398_abnormal_bone_marrow0.91389229
95MP0000343_altered_response_to0.89808309
96MP0005380_embryogenesis_phenotype0.88358851
97MP0001672_abnormal_embryogenesis/_devel0.88358851
98MP0000653_abnormal_sex_gland0.88228726
99MP0002085_abnormal_embryonic_tissue0.87413089
100MP0002090_abnormal_vision0.87092817
101MP0002419_abnormal_innate_immunity0.86931497
102MP0001727_abnormal_embryo_implantation0.86481712
103MP0002234_abnormal_pharynx_morphology0.84453048
104MP0005253_abnormal_eye_physiology0.83999709
105MP0004133_heterotaxia0.83943761
106MP0001800_abnormal_humoral_immune0.83898022
107MP0001881_abnormal_mammary_gland0.83621943
108MP0001542_abnormal_bone_strength0.82214791
109MP0002160_abnormal_reproductive_system0.82030912
110MP0002084_abnormal_developmental_patter0.81730101
111MP0000689_abnormal_spleen_morphology0.81190247
112MP0002452_abnormal_antigen_presenting0.80897726
113MP0005451_abnormal_body_composition0.80146220
114MP0002277_abnormal_respiratory_mucosa0.79961722
115MP0000716_abnormal_immune_system0.79437095
116MP0000313_abnormal_cell_death0.79425895
117MP0005084_abnormal_gallbladder_morpholo0.79252748
118MP0001286_abnormal_eye_development0.79086070
119MP0002722_abnormal_immune_system0.78993756
120MP0002429_abnormal_blood_cell0.78690510
121MP0005395_other_phenotype0.78482596
122MP0002735_abnormal_chemical_nociception0.77618393
123MP0005332_abnormal_amino_acid0.77580070
124MP0002080_prenatal_lethality0.77392815
125MP0002405_respiratory_system_inflammati0.77240185
126MP0006082_CNS_inflammation0.76780372
127MP0003315_abnormal_perineum_morphology0.75993825
128MP0001984_abnormal_olfaction0.74231500
129MP0005389_reproductive_system_phenotype0.73397950
130MP0005409_darkened_coat_color0.72507479
131MP0000631_abnormal_neuroendocrine_gland0.72336936
132MP0001485_abnormal_pinna_reflex0.70977668
133MP0002751_abnormal_autonomic_nervous0.70339375
134MP0005410_abnormal_fertilization0.70274309
135MP0002210_abnormal_sex_determination0.69762216
136MP0002736_abnormal_nociception_after0.69739158
137MP0001119_abnormal_female_reproductive0.69404750
138MP0000358_abnormal_cell_content/0.68852259
139MP0005367_renal/urinary_system_phenotyp0.68661140
140MP0000516_abnormal_urinary_system0.68661140
141MP0000703_abnormal_thymus_morphology0.68100240
142MP0003221_abnormal_cardiomyocyte_apopto0.68028621
143MP0000049_abnormal_middle_ear0.68004170
144MP0002111_abnormal_tail_morphology0.67878019
145MP0004145_abnormal_muscle_electrophysio0.67635262
146MP0009840_abnormal_foam_cell0.67448006
147MP0005330_cardiomyopathy0.66770811
148MP0002088_abnormal_embryonic_growth/wei0.66715768
149MP0005551_abnormal_eye_electrophysiolog0.66358950
150MP0008469_abnormal_protein_level0.65274087
151MP0003137_abnormal_impulse_conducting0.64593214
152MP0003984_embryonic_growth_retardation0.64555498

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.71729725
2Abnormal mitochondria in muscle tissue (HP:0008316)5.29663222
3Mitochondrial inheritance (HP:0001427)5.11979237
4Increased hepatocellular lipid droplets (HP:0006565)4.97471545
5Increased CSF lactate (HP:0002490)4.70406993
6Acute encephalopathy (HP:0006846)4.66780437
7Progressive macrocephaly (HP:0004481)4.65835294
8Abnormality of cells of the erythroid lineage (HP:0012130)4.53682830
9Lipid accumulation in hepatocytes (HP:0006561)4.50407196
10Hepatocellular necrosis (HP:0001404)4.50344506
11Reticulocytopenia (HP:0001896)4.40432386
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.30919224
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.30919224
14Abnormal number of erythroid precursors (HP:0012131)4.27481588
15Hepatic necrosis (HP:0002605)4.10131390
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.95815046
17Renal Fanconi syndrome (HP:0001994)3.94822877
183-Methylglutaconic aciduria (HP:0003535)3.94586224
19Exertional dyspnea (HP:0002875)3.77421416
20Increased serum lactate (HP:0002151)3.70652978
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.60933233
22Increased intramyocellular lipid droplets (HP:0012240)3.56471492
23Macrocytic anemia (HP:0001972)3.34103897
24Increased serum pyruvate (HP:0003542)3.33794039
25Abnormality of glycolysis (HP:0004366)3.33794039
26Exercise intolerance (HP:0003546)3.31088695
27Cerebral edema (HP:0002181)3.23767284
28Lactic acidosis (HP:0003128)3.23684148
29Pallor (HP:0000980)3.14685166
30Birth length less than 3rd percentile (HP:0003561)3.14087753
31Respiratory difficulties (HP:0002880)3.12040781
32Abnormality of alanine metabolism (HP:0010916)3.09607359
33Hyperalaninemia (HP:0003348)3.09607359
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09607359
35Increased muscle lipid content (HP:0009058)3.05728332
36Type I transferrin isoform profile (HP:0003642)2.97741433
37Aplastic anemia (HP:0001915)2.92617073
38Respiratory failure (HP:0002878)2.86179599
39Methylmalonic acidemia (HP:0002912)2.85437174
40Colon cancer (HP:0003003)2.84747148
41Optic disc pallor (HP:0000543)2.81768618
42Abnormality of renal resorption (HP:0011038)2.75192776
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73008126
44Abnormality of methionine metabolism (HP:0010901)2.70200256
45Microvesicular hepatic steatosis (HP:0001414)2.68418185
46Abnormality of the labia minora (HP:0012880)2.67778552
47Leukodystrophy (HP:0002415)2.66249736
48Methylmalonic aciduria (HP:0012120)2.57535082
49Breast hypoplasia (HP:0003187)2.56434066
50Reduced antithrombin III activity (HP:0001976)2.49211108
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49007770
52Abnormality of serum amino acid levels (HP:0003112)2.47186491
53Hyperglycinemia (HP:0002154)2.41234081
54Meckel diverticulum (HP:0002245)2.38501442
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32905909
56Degeneration of anterior horn cells (HP:0002398)2.32022248
57Abnormality of the anterior horn cell (HP:0006802)2.32022248
58Hypothermia (HP:0002045)2.31661731
59Oral leukoplakia (HP:0002745)2.26632670
60Abnormality of the ileum (HP:0001549)2.24935609
61Multiple enchondromatosis (HP:0005701)2.23791060
62Parakeratosis (HP:0001036)2.20131985
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.16498183
64Abnormal lung lobation (HP:0002101)2.15370664
65Abnormal protein glycosylation (HP:0012346)2.13149720
66Abnormal glycosylation (HP:0012345)2.13149720
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13149720
68Abnormal protein N-linked glycosylation (HP:0012347)2.13149720
69Septo-optic dysplasia (HP:0100842)2.12915714
70Glycosuria (HP:0003076)2.10525912
71Abnormality of urine glucose concentration (HP:0011016)2.10525912
72CNS demyelination (HP:0007305)2.09250871
73Sparse eyelashes (HP:0000653)2.04824371
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.03793593
7511 pairs of ribs (HP:0000878)2.00881595
76Type 2 muscle fiber atrophy (HP:0003554)1.99512868
77Microretrognathia (HP:0000308)1.95998706
78Abnormality of midbrain morphology (HP:0002418)1.95771071
79Molar tooth sign on MRI (HP:0002419)1.95771071
80Stenosis of the external auditory canal (HP:0000402)1.92695947
81Hyperphosphaturia (HP:0003109)1.91580158
82Abnormality of chromosome stability (HP:0003220)1.90304922
83Irregular epiphyses (HP:0010582)1.89845709
84Megaloblastic anemia (HP:0001889)1.87019830
85Amniotic constriction ring (HP:0009775)1.87008928
86Abnormality of placental membranes (HP:0011409)1.87008928
87Cerebral hypomyelination (HP:0006808)1.86607835
88Horseshoe kidney (HP:0000085)1.84826967
89Pancytopenia (HP:0001876)1.84120556
90Rough bone trabeculation (HP:0100670)1.83614693
91Renal tubular dysfunction (HP:0000124)1.83512156
92Glossoptosis (HP:0000162)1.83111280
93Congenital ichthyosiform erythroderma (HP:0007431)1.80030564
94Hyperglycinuria (HP:0003108)1.79606208
95Facial cleft (HP:0002006)1.78801791
96Duodenal stenosis (HP:0100867)1.77446836
97Small intestinal stenosis (HP:0012848)1.77446836
98Tongue fasciculations (HP:0001308)1.76744887
99Abnormal hair whorl (HP:0010721)1.76101769
100Lethargy (HP:0001254)1.75289972
101Abnormality of serine family amino acid metabolism (HP:0010894)1.74381320
102Abnormality of glycine metabolism (HP:0010895)1.74381320
103Absent septum pellucidum (HP:0001331)1.73610964
104Pancreatic fibrosis (HP:0100732)1.73102915
105Chromsome breakage (HP:0040012)1.72898509
106Emotional lability (HP:0000712)1.72778054
107IgM deficiency (HP:0002850)1.71624939
108Medial flaring of the eyebrow (HP:0010747)1.70325278
109Muscle fiber atrophy (HP:0100295)1.69991996
110Abnormality of vitamin B metabolism (HP:0004340)1.68565389
111Abnormality of the duodenum (HP:0002246)1.68534041
112Secondary amenorrhea (HP:0000869)1.68362732
113Gliosis (HP:0002171)1.68021741
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67669631
115True hermaphroditism (HP:0010459)1.63997542
116Pancreatic cysts (HP:0001737)1.62978006
117Duplicated collecting system (HP:0000081)1.62894670
118Petechiae (HP:0000967)1.62325547
119X-linked dominant inheritance (HP:0001423)1.60077459
120IgG deficiency (HP:0004315)1.59584398
121Congenital, generalized hypertrichosis (HP:0004540)1.59513032
122Blindness (HP:0000618)1.58789396
123Poor head control (HP:0002421)1.58165723
124Elevated erythrocyte sedimentation rate (HP:0003565)1.57838645
125Abnormality of the preputium (HP:0100587)1.57431416
126Absent thumb (HP:0009777)1.57341755
127Hypokinesia (HP:0002375)1.56931758
128Abnormal hemoglobin (HP:0011902)1.55724715
129Abnormality of secondary sexual hair (HP:0009888)1.55589427
130Abnormality of the axillary hair (HP:0100134)1.55589427
131Aplasia/hypoplasia of the uterus (HP:0008684)1.52486566
132Cleft eyelid (HP:0000625)1.50734765
133Premature graying of hair (HP:0002216)1.49674725
134Abnormal urine phosphate concentration (HP:0012599)1.48409067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.84066268
2STK163.89205087
3NME23.86262194
4VRK23.61958661
5BUB13.44748270
6MST43.20132782
7ARAF2.50005748
8TLK12.32783398
9SRPK12.31073220
10VRK12.23260075
11WEE12.22157081
12MAP3K122.19445625
13NEK12.19247330
14PIM22.03461184
15TRIM281.99827451
16EIF2AK31.94385369
17PDK21.93913078
18NUAK11.93057682
19NME11.83061223
20PBK1.80636058
21PLK41.63377653
22TAF11.53873582
23MAP4K21.52044409
24TXK1.51986418
25BMPR1B1.46043954
26DYRK31.44695252
27BRAF1.43022252
28MKNK11.39594260
29BMPR21.37089800
30WNK31.36206675
31IRAK31.31632308
32IRAK41.24462064
33CCNB11.21693186
34CASK1.19921183
35ACVR1B1.17549049
36ZAK1.15506247
37MKNK21.14318383
38GRK11.13302982
39BRSK21.13078192
40TSSK61.12353751
41LIMK11.08510104
42TNIK1.07388424
43GRK71.06796938
44TEC1.04720159
45DYRK20.99515019
46FRK0.97317820
47ADRBK20.96288576
48EIF2AK20.95420424
49PLK30.92816866
50MYLK0.89971662
51ABL20.89918436
52AURKA0.88096955
53BCR0.87060804
54PLK10.87057838
55CSNK1G30.86516749
56RPS6KA50.85796872
57MAP2K70.85186834
58CDK190.84316420
59RPS6KA40.83512727
60MUSK0.81468690
61CDC70.81228364
62CDK80.79060510
63AURKB0.77835635
64STK38L0.77803671
65STK390.75773157
66MOS0.71878467
67MAP3K140.68399439
68CSNK2A10.67100169
69YES10.66615246
70STK240.65532956
71TESK10.61338048
72MAP2K60.60145862
73PAK40.59120820
74OXSR10.59036672
75CSNK2A20.58835299
76IKBKB0.56290522
77CSNK1A1L0.55875272
78PASK0.54854096
79MAPK130.54537189
80PNCK0.53821623
81ERBB30.52970488
82STK30.52441416
83RAF10.52120550
84DAPK10.51184796
85MAP3K40.50826422
86MAPKAPK50.49631407
87ATM0.49224900
88TTK0.48632574
89KDR0.48526835
90LYN0.48145990
91OBSCN0.47647526
92INSRR0.46182297
93ATR0.45785154
94SCYL20.45336314
95CSNK1G10.45206702
96CHEK20.44795582
97ILK0.44584355
98MAP3K110.44338149
99PAK10.41239833
100CDK70.40780836
101SYK0.40521454
102PLK20.40299726
103PIM10.39785286
104PDK40.39633477
105PDK30.39633477
106CSNK1E0.39004590
107CHEK10.38509715
108FGFR10.37355015
109TESK20.37052651
110BLK0.36625863
111ADRBK10.36376555
112PIK3CG0.36239732
113ERBB40.36228604
114GRK50.35601139
115CSNK1A10.35284993
116PRKCI0.34543205
117BCKDK0.34199167
118DAPK30.34135880
119CDK30.33748753
120ALK0.33389165
121PRKCE0.32624563
122BRSK10.32554309
123MAP3K60.30576337
124TGFBR10.30180693
125CSNK1G20.29483099
126MAP3K130.29463637
127MAPK40.29069443
128STK40.29030823
129RPS6KB20.28477104
130MINK10.27719699
131TIE10.27669596
132CLK10.27362640
133PRKCG0.24024091
134PINK10.23380990
135NEK60.22894229
136FLT30.22751448
137CDK10.21221317

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.20242637
2Proteasome_Homo sapiens_hsa030504.69737366
3Oxidative phosphorylation_Homo sapiens_hsa001903.99463690
4RNA polymerase_Homo sapiens_hsa030203.75099661
5Parkinsons disease_Homo sapiens_hsa050123.49869077
6Protein export_Homo sapiens_hsa030602.97891216
7Huntingtons disease_Homo sapiens_hsa050162.64412410
8DNA replication_Homo sapiens_hsa030302.55531195
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48747179
10Alzheimers disease_Homo sapiens_hsa050102.43704308
11Pyrimidine metabolism_Homo sapiens_hsa002402.42929800
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16596208
13Homologous recombination_Homo sapiens_hsa034402.15862429
14Mismatch repair_Homo sapiens_hsa034302.15355685
15Spliceosome_Homo sapiens_hsa030402.14651297
16Basal transcription factors_Homo sapiens_hsa030221.92502790
17Nucleotide excision repair_Homo sapiens_hsa034201.87624148
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87023468
19RNA transport_Homo sapiens_hsa030131.58005121
20RNA degradation_Homo sapiens_hsa030181.52340669
21Base excision repair_Homo sapiens_hsa034101.51569454
22Non-homologous end-joining_Homo sapiens_hsa034501.47386108
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40753868
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40406202
25Purine metabolism_Homo sapiens_hsa002301.39012942
26Fanconi anemia pathway_Homo sapiens_hsa034601.35382482
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28873872
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27458330
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26624425
30Folate biosynthesis_Homo sapiens_hsa007901.26439020
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25406700
32Cell cycle_Homo sapiens_hsa041101.17664323
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05221957
34Selenocompound metabolism_Homo sapiens_hsa004501.03358795
35Cardiac muscle contraction_Homo sapiens_hsa042601.00466088
36Fatty acid elongation_Homo sapiens_hsa000620.98792609
37Glutathione metabolism_Homo sapiens_hsa004800.95065975
38Graft-versus-host disease_Homo sapiens_hsa053320.93526033
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92657615
40Sulfur relay system_Homo sapiens_hsa041220.92221505
41Arachidonic acid metabolism_Homo sapiens_hsa005900.91272464
42Allograft rejection_Homo sapiens_hsa053300.85689044
43Epstein-Barr virus infection_Homo sapiens_hsa051690.85305610
44Systemic lupus erythematosus_Homo sapiens_hsa053220.84827825
45Sulfur metabolism_Homo sapiens_hsa009200.79037586
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77982819
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73237854
48p53 signaling pathway_Homo sapiens_hsa041150.72932616
49Tryptophan metabolism_Homo sapiens_hsa003800.72004621
50Metabolic pathways_Homo sapiens_hsa011000.71227583
51Rheumatoid arthritis_Homo sapiens_hsa053230.70110992
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68473043
53Butanoate metabolism_Homo sapiens_hsa006500.68083507
54Linoleic acid metabolism_Homo sapiens_hsa005910.67909267
55Vitamin B6 metabolism_Homo sapiens_hsa007500.67313088
56One carbon pool by folate_Homo sapiens_hsa006700.66483471
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.65229834
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65095620
59Biosynthesis of amino acids_Homo sapiens_hsa012300.64561085
60Primary immunodeficiency_Homo sapiens_hsa053400.63017228
61Regulation of autophagy_Homo sapiens_hsa041400.62214374
62Legionellosis_Homo sapiens_hsa051340.60393682
63Caffeine metabolism_Homo sapiens_hsa002320.59659012
64Asthma_Homo sapiens_hsa053100.58841357
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57684077
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57665647
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56595011
68Ether lipid metabolism_Homo sapiens_hsa005650.56273376
69Collecting duct acid secretion_Homo sapiens_hsa049660.55009120
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54129917
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51906121
72Pentose phosphate pathway_Homo sapiens_hsa000300.51676726
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51466833
74N-Glycan biosynthesis_Homo sapiens_hsa005100.50713062
75Fatty acid degradation_Homo sapiens_hsa000710.49682687
76Steroid biosynthesis_Homo sapiens_hsa001000.49117664
77Arginine and proline metabolism_Homo sapiens_hsa003300.48730225
78Oocyte meiosis_Homo sapiens_hsa041140.48474294
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46904575
80Other glycan degradation_Homo sapiens_hsa005110.46882131
81Autoimmune thyroid disease_Homo sapiens_hsa053200.46314561
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.45755237
83Sphingolipid metabolism_Homo sapiens_hsa006000.45723841
84Antigen processing and presentation_Homo sapiens_hsa046120.45630236
85Type I diabetes mellitus_Homo sapiens_hsa049400.45392236
86Vitamin digestion and absorption_Homo sapiens_hsa049770.43273616
87Vibrio cholerae infection_Homo sapiens_hsa051100.43267707
88Herpes simplex infection_Homo sapiens_hsa051680.42629444
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41940407
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41699191
91Phototransduction_Homo sapiens_hsa047440.40960722
92Pyruvate metabolism_Homo sapiens_hsa006200.40696867
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.40395316
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38207732
95beta-Alanine metabolism_Homo sapiens_hsa004100.38126818
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37534808
97Hematopoietic cell lineage_Homo sapiens_hsa046400.37130394
98Fatty acid metabolism_Homo sapiens_hsa012120.36927890
99Peroxisome_Homo sapiens_hsa041460.35300073
100Tyrosine metabolism_Homo sapiens_hsa003500.32556028
101mRNA surveillance pathway_Homo sapiens_hsa030150.32422482
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31334083
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31243508
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31197535
105Phagosome_Homo sapiens_hsa041450.31196089
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.30945909
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30537058
108Phenylalanine metabolism_Homo sapiens_hsa003600.28892027
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27304608
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27098656
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.26500108
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25717640
113Shigellosis_Homo sapiens_hsa051310.23988917
114Alcoholism_Homo sapiens_hsa050340.23062761
115Retinol metabolism_Homo sapiens_hsa008300.22028839
116Malaria_Homo sapiens_hsa051440.20871843
117Pertussis_Homo sapiens_hsa051330.20478915
118Propanoate metabolism_Homo sapiens_hsa006400.20456544
119Nitrogen metabolism_Homo sapiens_hsa009100.20118532
120Chemical carcinogenesis_Homo sapiens_hsa052040.20024517
121Measles_Homo sapiens_hsa051620.19606132
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19337904
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.18642718
124Carbon metabolism_Homo sapiens_hsa012000.18331183
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17896814
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16308273
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15909944
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15754538
129TGF-beta signaling pathway_Homo sapiens_hsa043500.14652612
130Mineral absorption_Homo sapiens_hsa049780.13869835
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.11458805
132Fat digestion and absorption_Homo sapiens_hsa049750.10258092

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