MRPL33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.66743095
2ribosomal small subunit biogenesis (GO:0042274)6.39293128
3ATP synthesis coupled proton transport (GO:0015986)6.30878234
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.30878234
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.23090244
6ribosomal small subunit assembly (GO:0000028)5.81746474
7viral transcription (GO:0019083)5.74252799
8translational termination (GO:0006415)5.52718197
9respiratory electron transport chain (GO:0022904)5.40112580
10cotranslational protein targeting to membrane (GO:0006613)5.31421025
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.25717580
12electron transport chain (GO:0022900)5.24568652
13protein targeting to ER (GO:0045047)5.22970540
14protein localization to endoplasmic reticulum (GO:0070972)5.01377504
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98927640
16protein neddylation (GO:0045116)4.73121453
17GTP biosynthetic process (GO:0006183)4.53767130
18translational elongation (GO:0006414)4.44470585
19central nervous system myelination (GO:0022010)4.32078359
20axon ensheathment in central nervous system (GO:0032291)4.32078359
21viral life cycle (GO:0019058)4.31812169
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.29358860
23NADH dehydrogenase complex assembly (GO:0010257)4.29358860
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29358860
25cellular protein complex disassembly (GO:0043624)4.27483488
26proteasome assembly (GO:0043248)4.26657264
27maturation of SSU-rRNA (GO:0030490)4.23237176
28protein complex biogenesis (GO:0070271)4.14318235
29chaperone-mediated protein transport (GO:0072321)4.05748528
30ribosomal large subunit biogenesis (GO:0042273)3.89129802
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.82954887
32termination of RNA polymerase III transcription (GO:0006386)3.79433137
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.79433137
34UTP biosynthetic process (GO:0006228)3.78876639
35oxidative phosphorylation (GO:0006119)3.78190619
36translational initiation (GO:0006413)3.77383056
37* translation (GO:0006412)3.74466059
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.73346289
39mitochondrial respiratory chain complex assembly (GO:0033108)3.73186721
40DNA deamination (GO:0045006)3.65993255
41sequestering of actin monomers (GO:0042989)3.56395331
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.50665306
43GPI anchor biosynthetic process (GO:0006506)3.48742756
44intracellular protein transmembrane import (GO:0044743)3.46174534
45protein targeting to membrane (GO:0006612)3.45283021
46protein complex disassembly (GO:0043241)3.43805356
47rRNA modification (GO:0000154)3.40122296
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39859479
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39731020
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39731020
51respiratory chain complex IV assembly (GO:0008535)3.37303809
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.36002244
53CTP metabolic process (GO:0046036)3.31108594
54CTP biosynthetic process (GO:0006241)3.31108594
55mitochondrial transport (GO:0006839)3.28946680
56neutrophil activation involved in immune response (GO:0002283)3.26891947
57mannosylation (GO:0097502)3.25875178
58macromolecular complex disassembly (GO:0032984)3.24931178
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24090218
60guanosine-containing compound biosynthetic process (GO:1901070)3.22709219
61DNA damage response, detection of DNA damage (GO:0042769)3.21151946
62water-soluble vitamin biosynthetic process (GO:0042364)3.21109335
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20108682
64UTP metabolic process (GO:0046051)3.17293176
65protein targeting to mitochondrion (GO:0006626)3.16212702
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16009801
67regulation of cellular amino acid metabolic process (GO:0006521)3.12221568
68cytochrome complex assembly (GO:0017004)3.11034177
69aerobic respiration (GO:0009060)3.10678117
70nucleoside triphosphate biosynthetic process (GO:0009142)3.10513758
71hydrogen ion transmembrane transport (GO:1902600)3.09709342
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08633579
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08567231
74protein-cofactor linkage (GO:0018065)3.08078985
75spliceosomal snRNP assembly (GO:0000387)3.06772877
76establishment of protein localization to mitochondrion (GO:0072655)3.05327831
77purine nucleoside monophosphate biosynthetic process (GO:0009127)3.03481615
78purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.03481615
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02696191
80establishment of integrated proviral latency (GO:0075713)3.02479769
81establishment of viral latency (GO:0019043)3.01683207
82fatty acid elongation (GO:0030497)3.01219663
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00643242
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00643242
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99710723
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99710723
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99710723
88GPI anchor metabolic process (GO:0006505)2.98916151
89mRNA catabolic process (GO:0006402)2.98447788
90spliceosomal complex assembly (GO:0000245)2.98079707
91organelle disassembly (GO:1903008)2.97209247
92regulation of mitochondrial translation (GO:0070129)2.96161010
93signal peptide processing (GO:0006465)2.94310803
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93512684
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92409529
96negative regulation of ligase activity (GO:0051352)2.92409529
97positive regulation of ligase activity (GO:0051351)2.89685538
98cullin deneddylation (GO:0010388)2.88800113
99ATP biosynthetic process (GO:0006754)2.87039671
100pseudouridine synthesis (GO:0001522)2.86992051
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86401103
1027-methylguanosine RNA capping (GO:0009452)2.86358092
103RNA capping (GO:0036260)2.86358092
104ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86237611
105proton transport (GO:0015992)2.86212644
106cellular component biogenesis (GO:0044085)2.85522675
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.84724698
108signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84724698
109pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84366137
1107-methylguanosine mRNA capping (GO:0006370)2.83346049
111CENP-A containing nucleosome assembly (GO:0034080)2.81128489
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.80949285
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80896862
114pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80416578
115preassembly of GPI anchor in ER membrane (GO:0016254)2.80308847
116chromatin remodeling at centromere (GO:0031055)2.79624700
117hydrogen transport (GO:0006818)2.77110261
118nucleoside diphosphate phosphorylation (GO:0006165)2.77063750
119ribonucleoprotein complex biogenesis (GO:0022613)2.76987653
120nuclear-transcribed mRNA catabolic process (GO:0000956)2.76617481
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75134446
122peptidyl-histidine modification (GO:0018202)2.74037361
123protein localization to mitochondrion (GO:0070585)2.72959599
124inner mitochondrial membrane organization (GO:0007007)2.72197950
125antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68298800
126platelet dense granule organization (GO:0060155)2.66597089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.39698069
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.61265326
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.56507518
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.30408909
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.87432156
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.27497802
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25273681
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05902099
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05818687
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05504934
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98243273
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91158810
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.90129371
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80276721
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68381076
16ELK1_19687146_ChIP-ChIP_HELA_Human2.62692444
17* MYC_18555785_ChIP-Seq_MESCs_Mouse2.46100034
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40113467
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.36938863
20VDR_23849224_ChIP-Seq_CD4+_Human2.29439210
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11974998
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10352370
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99856831
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93195580
25DCP1A_22483619_ChIP-Seq_HELA_Human1.90202613
26* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86114116
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82426775
28* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80607020
29VDR_22108803_ChIP-Seq_LS180_Human1.77662171
30ZNF274_21170338_ChIP-Seq_K562_Hela1.76411491
31* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71383773
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.70283311
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70153494
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69039502
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.65096429
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.63847224
37FOXP3_21729870_ChIP-Seq_TREG_Human1.62855233
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62778079
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61220924
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57673875
41IRF1_19129219_ChIP-ChIP_H3396_Human1.56783453
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56675785
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54124949
44TTF2_22483619_ChIP-Seq_HELA_Human1.53141358
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50912246
46XRN2_22483619_ChIP-Seq_HELA_Human1.49751441
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44245662
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42131137
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41049835
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37586202
51MYC_18940864_ChIP-ChIP_HL60_Human1.37164894
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33969080
53TAF15_26573619_Chip-Seq_HEK293_Human1.33484063
54SPI1_23547873_ChIP-Seq_NB4_Human1.32478704
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31434185
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31206230
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29881159
58FUS_26573619_Chip-Seq_HEK293_Human1.29115134
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27911145
60* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25865107
61P300_19829295_ChIP-Seq_ESCs_Human1.24619071
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23073158
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21472361
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20361254
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.19672124
66TP53_22573176_ChIP-Seq_HFKS_Human1.17109114
67* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17079544
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14391494
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13445845
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11831595
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10659536
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09716768
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09338044
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.06987423
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05875689
76EWS_26573619_Chip-Seq_HEK293_Human1.03017413
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02633354
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02462526
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02193041
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01643610
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.01498159
82ER_23166858_ChIP-Seq_MCF-7_Human1.00270907
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99904693
84HTT_18923047_ChIP-ChIP_STHdh_Human0.99630088
85* GABP_19822575_ChIP-Seq_HepG2_Human0.99120285
86SOX2_19829295_ChIP-Seq_ESCs_Human0.98340344
87NANOG_19829295_ChIP-Seq_ESCs_Human0.98340344
88IRF8_22096565_ChIP-ChIP_GC-B_Human0.97933985
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.97611792
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95806919
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.94812833
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92947361
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92643601
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92397884
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92164826
96* AR_20517297_ChIP-Seq_VCAP_Human0.90521093
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90318056
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90190461
99* FOXA1_25329375_ChIP-Seq_VCAP_Human0.90174234
100* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90174234
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89745233
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88433771
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88138369
104STAT1_20625510_ChIP-Seq_HELA_Human0.87468497
105PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82564068
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81158016
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80375121
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78363576
109* ERG_20517297_ChIP-Seq_VCAP_Human0.77789779
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77461016
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77438641
112IGF1R_20145208_ChIP-Seq_DFB_Human0.77055010
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76737200
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.76494212
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76385660
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76378561
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75817446
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75501468
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.74932285
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74920180
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.74776828
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.74757224
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74699018
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74433082
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.74400605
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74317641
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74250349
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74248425
129CBP_20019798_ChIP-Seq_JUKART_Human0.74248425
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73131724
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.72890264
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72775012
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70424081
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.70280076
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69163125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.30778932
2MP0003136_yellow_coat_color4.27437606
3MP0004381_abnormal_hair_follicle2.94018703
4MP0003724_increased_susceptibility_to2.79145214
5MP0001529_abnormal_vocalization2.66459812
6MP0002148_abnormal_hypersensitivity_rea2.62946420
7MP0009785_altered_susceptibility_to2.47127140
8MP0001905_abnormal_dopamine_level2.45872097
9MP0000372_irregular_coat_pigmentation2.45302775
10MP0005171_absent_coat_pigmentation2.34741268
11MP0000920_abnormal_myelination2.33560371
12MP0005409_darkened_coat_color2.22081341
13MP0001835_abnormal_antigen_presentation2.08028106
14MP0003880_abnormal_central_pattern1.95548786
15MP0003186_abnormal_redox_activity1.94791780
16MP0005671_abnormal_response_to1.89076318
17MP0003950_abnormal_plasma_membrane1.84578461
18MP0005025_abnormal_response_to1.82679181
19MP0001986_abnormal_taste_sensitivity1.81906481
20MP0005000_abnormal_immune_tolerance1.80263756
21MP0001984_abnormal_olfaction1.76825124
22MP0008789_abnormal_olfactory_epithelium1.70243305
23MP0001188_hyperpigmentation1.68232251
24MP0002419_abnormal_innate_immunity1.67215549
25MP0008877_abnormal_DNA_methylation1.63237586
26MP0002938_white_spotting1.62496868
27MP0010030_abnormal_orbit_morphology1.61881786
28MP0005075_abnormal_melanosome_morpholog1.59611132
29MP0008057_abnormal_DNA_replication1.58159285
30MP0002234_abnormal_pharynx_morphology1.57586238
31MP0002163_abnormal_gland_morphology1.57006804
32MP0005253_abnormal_eye_physiology1.55350010
33MP0002132_abnormal_respiratory_system1.52581060
34MP0004142_abnormal_muscle_tone1.47270265
35MP0004147_increased_porphyrin_level1.46372481
36MP0004215_abnormal_myocardial_fiber1.45957183
37MP0005174_abnormal_tail_pigmentation1.43284487
38MP0003436_decreased_susceptibility_to1.42932848
39MP0005408_hypopigmentation1.42420781
40MP0003646_muscle_fatigue1.41102253
41MP0006036_abnormal_mitochondrial_physio1.40497755
42MP0000631_abnormal_neuroendocrine_gland1.40354411
43MP0008995_early_reproductive_senescence1.40065736
44MP0005551_abnormal_eye_electrophysiolog1.39304252
45MP0001853_heart_inflammation1.38538394
46MP0002277_abnormal_respiratory_mucosa1.37354139
47MP0002723_abnormal_immune_serum1.32747291
48MP0003195_calcinosis1.31363110
49MP0008875_abnormal_xenobiotic_pharmacok1.31249536
50MP0009333_abnormal_splenocyte_physiolog1.29935365
51MP0001293_anophthalmia1.29583795
52MP0002420_abnormal_adaptive_immunity1.26158276
53MP0005379_endocrine/exocrine_gland_phen1.26061954
54MP0006082_CNS_inflammation1.25444384
55MP0002822_catalepsy1.25053002
56MP0001819_abnormal_immune_cell1.23966674
57MP0009046_muscle_twitch1.23403524
58MP0001790_abnormal_immune_system1.22490313
59MP0005387_immune_system_phenotype1.22490313
60MP0000015_abnormal_ear_pigmentation1.21600848
61MP0002736_abnormal_nociception_after1.21143859
62MP0000685_abnormal_immune_system1.21079032
63MP0001851_eye_inflammation1.17870103
64MP0002452_abnormal_antigen_presenting1.17772917
65MP0000749_muscle_degeneration1.16225696
66MP0003718_maternal_effect1.15860697
67MP0001542_abnormal_bone_strength1.15348179
68MP0000343_altered_response_to1.13882960
69MP0002095_abnormal_skin_pigmentation1.12678293
70MP0003283_abnormal_digestive_organ1.12095880
71MP0006292_abnormal_olfactory_placode1.11735741
72MP0002160_abnormal_reproductive_system1.11359762
73MP0000465_gastrointestinal_hemorrhage1.07867849
74MP0001800_abnormal_humoral_immune1.06817467
75MP0001764_abnormal_homeostasis1.06058297
76MP0001968_abnormal_touch/_nociception1.05587429
77MP0008932_abnormal_embryonic_tissue1.05032176
78MP0006035_abnormal_mitochondrial_morpho1.04768977
79MP0002405_respiratory_system_inflammati1.04409578
80MP0002933_joint_inflammation1.04282693
81MP0004742_abnormal_vestibular_system1.03762411
82MP0005332_abnormal_amino_acid1.03706265
83MP0002272_abnormal_nervous_system1.03333908
84MP0003137_abnormal_impulse_conducting1.02594069
85MP0002006_tumorigenesis1.02420612
86MP0005646_abnormal_pituitary_gland1.01976909
87MP0002751_abnormal_autonomic_nervous1.01543649
88MP0002282_abnormal_trachea_morphology0.99487928
89MP0003786_premature_aging0.99036726
90MP0005645_abnormal_hypothalamus_physiol0.99028649
91MP0004133_heterotaxia0.98379110
92MP0001485_abnormal_pinna_reflex0.96855099
93MP0003938_abnormal_ear_development0.94060193
94MP0001286_abnormal_eye_development0.93927529
95MP0000049_abnormal_middle_ear0.93794571
96MP0009745_abnormal_behavioral_response0.93647655
97MP0000566_synostosis0.93443598
98MP0005389_reproductive_system_phenotype0.92873931
99MP0003011_delayed_dark_adaptation0.92819470
100MP0003763_abnormal_thymus_physiology0.91957285
101MP0005164_abnormal_response_to0.91167722
102MP0002009_preneoplasia0.90925560
103MP0003567_abnormal_fetal_cardiomyocyte0.89318837
104MP0002837_dystrophic_cardiac_calcinosis0.88923712
105MP0002233_abnormal_nose_morphology0.88396495
106MP0002166_altered_tumor_susceptibility0.88318509
107MP0003121_genomic_imprinting0.88297132
108MP0005195_abnormal_posterior_eye0.87346222
109MP0001727_abnormal_embryo_implantation0.86750438
110MP0001346_abnormal_lacrimal_gland0.86319526
111MP0008260_abnormal_autophagy0.86183642
112MP0008872_abnormal_physiological_respon0.85394411
113MP0003315_abnormal_perineum_morphology0.84174669
114MP0000716_abnormal_immune_system0.83560400
115MP0000026_abnormal_inner_ear0.83550459
116MP0005266_abnormal_metabolism0.82440422
117MP0002210_abnormal_sex_determination0.82321614
118MP0006276_abnormal_autonomic_nervous0.81900696
119MP0000383_abnormal_hair_follicle0.81788147
120MP0002638_abnormal_pupillary_reflex0.81444629
121MP0003806_abnormal_nucleotide_metabolis0.81353389
122MP0005391_vision/eye_phenotype0.81164661
123MP0005394_taste/olfaction_phenotype0.80218431
124MP0005499_abnormal_olfactory_system0.80218431
125MP0001533_abnormal_skeleton_physiology0.79782131
126MP0000750_abnormal_muscle_regeneration0.78430222
127MP0003941_abnormal_skin_development0.78071059
128MP0010094_abnormal_chromosome_stability0.77775039
129MP0002928_abnormal_bile_duct0.76593102
130MP0009250_abnormal_appendicular_skeleto0.76323117
131MP0002396_abnormal_hematopoietic_system0.75418832
132MP0008058_abnormal_DNA_repair0.75413373
133MP0005410_abnormal_fertilization0.74876081
134MP0003122_maternal_imprinting0.74186980
135MP0003937_abnormal_limbs/digits/tail_de0.74051845
136MP0005330_cardiomyopathy0.73786784
137MP0000858_altered_metastatic_potential0.72696394
138MP0005620_abnormal_muscle_contractility0.72684792
139MP0003077_abnormal_cell_cycle0.72624596
140MP0001845_abnormal_inflammatory_respons0.72283116
141MP0002752_abnormal_somatic_nervous0.71345660
142MP0009697_abnormal_copulation0.71168755
143MP0006072_abnormal_retinal_apoptosis0.70080432
144MP0002102_abnormal_ear_morphology0.69953213
145MP0010386_abnormal_urinary_bladder0.69347087
146MP0003693_abnormal_embryo_hatching0.69326920
147MP0001929_abnormal_gametogenesis0.69293144
148MP0008469_abnormal_protein_level0.68525244
149MP0004782_abnormal_surfactant_physiolog0.67888801
150MP0004085_abnormal_heartbeat0.67866022
151MP0008438_abnormal_cutaneous_collagen0.67699776
152MP0005423_abnormal_somatic_nervous0.67611581
153MP0002876_abnormal_thyroid_physiology0.67575119
154MP0002295_abnormal_pulmonary_circulatio0.67455470
155MP0002398_abnormal_bone_marrow0.66559749
156MP0004957_abnormal_blastocyst_morpholog0.66276576
157MP0002429_abnormal_blood_cell0.65324889
158MP0004145_abnormal_muscle_electrophysio0.64107086
159MP0005084_abnormal_gallbladder_morpholo0.62884871
160MP0006054_spinal_hemorrhage0.62848319

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.85905418
2Mitochondrial inheritance (HP:0001427)5.46788340
3Abnormality of cells of the erythroid lineage (HP:0012130)5.13615283
4Abnormal mitochondria in muscle tissue (HP:0008316)5.07002482
5Progressive macrocephaly (HP:0004481)4.90282539
6Increased hepatocellular lipid droplets (HP:0006565)4.87519829
7Parakeratosis (HP:0001036)4.75614983
8Abnormal number of erythroid precursors (HP:0012131)4.75248156
9Hepatocellular necrosis (HP:0001404)4.70994015
10Renal Fanconi syndrome (HP:0001994)4.66433767
11Acute encephalopathy (HP:0006846)4.55253560
12Increased CSF lactate (HP:0002490)4.50565273
13Lipid accumulation in hepatocytes (HP:0006561)4.23909919
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.18563395
15Hepatic necrosis (HP:0002605)4.11210958
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.07153993
17Reticulocytopenia (HP:0001896)4.01055585
183-Methylglutaconic aciduria (HP:0003535)3.92112185
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.77744585
20Exertional dyspnea (HP:0002875)3.65797032
21Macrocytic anemia (HP:0001972)3.23640074
22Increased intramyocellular lipid droplets (HP:0012240)3.22477668
23Exercise intolerance (HP:0003546)3.21268286
24Respiratory failure (HP:0002878)3.21249928
25Optic disc pallor (HP:0000543)3.04392784
26Abnormality of renal resorption (HP:0011038)3.03397132
27Congenital ichthyosiform erythroderma (HP:0007431)3.03100297
28Respiratory difficulties (HP:0002880)2.99001836
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97883705
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97883705
31Leukodystrophy (HP:0002415)2.96897789
32Increased serum lactate (HP:0002151)2.91712822
33Cerebral edema (HP:0002181)2.88029058
34Pallor (HP:0000980)2.84073835
35Recurrent abscess formation (HP:0002722)2.81588907
36Methylmalonic acidemia (HP:0002912)2.80941352
37Abnormality of glycolysis (HP:0004366)2.74179015
38Increased serum pyruvate (HP:0003542)2.74179015
39Type I transferrin isoform profile (HP:0003642)2.73263324
40Lactic acidosis (HP:0003128)2.69105249
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63875333
42Increased muscle lipid content (HP:0009058)2.62454030
43Patchy hypopigmentation of hair (HP:0011365)2.57981305
44Lethargy (HP:0001254)2.54264920
45Pancreatic cysts (HP:0001737)2.50832058
46Abnormality of midbrain morphology (HP:0002418)2.45903456
47Molar tooth sign on MRI (HP:0002419)2.45903456
48Recurrent bacterial skin infections (HP:0005406)2.42771691
49Pancreatic fibrosis (HP:0100732)2.40773031
50True hermaphroditism (HP:0010459)2.40062021
51Abnormality of the axillary hair (HP:0100134)2.34917486
52Abnormality of secondary sexual hair (HP:0009888)2.34917486
53Amniotic constriction ring (HP:0009775)2.29146589
54Abnormality of placental membranes (HP:0011409)2.29146589
55Methylmalonic aciduria (HP:0012120)2.25954657
56Septo-optic dysplasia (HP:0100842)2.21784446
57Generalized aminoaciduria (HP:0002909)2.19110239
58Nephronophthisis (HP:0000090)2.07094066
59Nemaline bodies (HP:0003798)2.04731145
60Obstructive lung disease (HP:0006536)2.03119717
61Chronic obstructive pulmonary disease (HP:0006510)2.03119717
62Oral leukoplakia (HP:0002745)2.02953085
63Muscle fiber inclusion bodies (HP:0100299)2.02715760
64Elevated erythrocyte sedimentation rate (HP:0003565)2.02478173
65Congenital, generalized hypertrichosis (HP:0004540)2.02254218
66Reduced antithrombin III activity (HP:0001976)2.01436661
67Glycosuria (HP:0003076)1.98450890
68Abnormality of urine glucose concentration (HP:0011016)1.98450890
69Abnormality of methionine metabolism (HP:0010901)1.96945875
70White forelock (HP:0002211)1.95930418
71Abnormality of macrophages (HP:0004311)1.93713129
72Hepatosplenomegaly (HP:0001433)1.93260193
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92591690
74Abnormality of the anterior horn cell (HP:0006802)1.88120843
75Degeneration of anterior horn cells (HP:0002398)1.88120843
76X-linked dominant inheritance (HP:0001423)1.85583710
77Abnormal hemoglobin (HP:0011902)1.85214432
78Exercise-induced muscle cramps (HP:0003710)1.84355707
79Microvesicular hepatic steatosis (HP:0001414)1.84309847
80Abnormal protein glycosylation (HP:0012346)1.82766157
81Abnormal glycosylation (HP:0012345)1.82766157
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82766157
83Abnormal protein N-linked glycosylation (HP:0012347)1.82766157
84Congenital primary aphakia (HP:0007707)1.81236189
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80282391
86Hyperglycinemia (HP:0002154)1.80261961
87Aplastic anemia (HP:0001915)1.79900455
88Poor head control (HP:0002421)1.78853906
89Gait imbalance (HP:0002141)1.78710847
90Abnormal ciliary motility (HP:0012262)1.78546675
91Sclerocornea (HP:0000647)1.78514877
92Renal tubular dysfunction (HP:0000124)1.78292621
93Petechiae (HP:0000967)1.78280675
94Hypothermia (HP:0002045)1.77306950
95Purpura (HP:0000979)1.77113621
96Cerebral hypomyelination (HP:0006808)1.77068282
97Abnormality of alanine metabolism (HP:0010916)1.76545096
98Hyperalaninemia (HP:0003348)1.76545096
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76545096
100Absent septum pellucidum (HP:0001331)1.76159346
101Hyperphosphaturia (HP:0003109)1.76131892
102Abnormal respiratory epithelium morphology (HP:0012253)1.75803118
103Abnormal respiratory motile cilium morphology (HP:0005938)1.75803118
104CNS demyelination (HP:0007305)1.75421857
105Abnormality of serum amino acid levels (HP:0003112)1.73991699
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73348220
107Dicarboxylic aciduria (HP:0003215)1.73348220
108Male pseudohermaphroditism (HP:0000037)1.72753360
109Vacuolated lymphocytes (HP:0001922)1.69868859
110Large for gestational age (HP:0001520)1.69049967
111Abnormal pupillary function (HP:0007686)1.68715368
112Nephrogenic diabetes insipidus (HP:0009806)1.68636040
113Aplasia/hypoplasia of the uterus (HP:0008684)1.68046699
114Palpitations (HP:0001962)1.66803350
115Megaloblastic anemia (HP:0001889)1.65275633
116Blindness (HP:0000618)1.64926872
117Recurrent skin infections (HP:0001581)1.64906458
118Abnormality of vitamin B metabolism (HP:0004340)1.64177021
119Duplicated collecting system (HP:0000081)1.63614257
120Stomatitis (HP:0010280)1.63550368
121Increased IgM level (HP:0003496)1.63492111
122Asplenia (HP:0001746)1.62575683
123Erythroderma (HP:0001019)1.62098642
124Calf muscle hypertrophy (HP:0008981)1.61691637
125Abnormality of the renal medulla (HP:0100957)1.61118364
126Emotional lability (HP:0000712)1.61047363
127Pancytopenia (HP:0001876)1.60790755
128Renal cortical cysts (HP:0000803)1.60493846
129Hypoglycemic coma (HP:0001325)1.60299490
130Retinal dysplasia (HP:0007973)1.59190688
131Muscle hypertrophy of the lower extremities (HP:0008968)1.58818559
132Partial duplication of thumb phalanx (HP:0009944)1.57697934
133Medial flaring of the eyebrow (HP:0010747)1.57351595
134Sparse eyelashes (HP:0000653)1.56467549
135Sensory axonal neuropathy (HP:0003390)1.54383289
136Stenosis of the external auditory canal (HP:0000402)1.52891446
137Rough bone trabeculation (HP:0100670)1.52479236
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.52467372
139Absent/shortened dynein arms (HP:0200106)1.52467372
140Abnormal urine phosphate concentration (HP:0012599)1.52029362
141Birth length less than 3rd percentile (HP:0003561)1.51524697
142Hypoplastic left heart (HP:0004383)1.50760320
143Prolonged neonatal jaundice (HP:0006579)1.48954667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.39386424
2STK163.85221659
3NME23.19232588
4PBK3.18597951
5STK392.76118687
6MST42.74228056
7NME12.38255216
8MUSK2.34488918
9PIM22.25873497
10TNIK2.24468303
11VRK12.21773098
12IRAK42.19706703
13MAP3K121.96286731
14MAP4K21.93907069
15MAPKAPK51.90879295
16WNK31.90003651
17MYLK1.87650587
18TLK11.84041758
19BMPR1B1.78654511
20EIF2AK31.74528802
21PHKG21.68655456
22PHKG11.68655456
23BUB11.68240355
24INSRR1.67350486
25PINK11.65042377
26OXSR11.63991244
27CASK1.61178736
28NEK11.56825227
29BCKDK1.56066158
30BLK1.55766842
31ZAK1.53145605
32TXK1.50906339
33CDC71.48587783
34TEC1.47265372
35BCR1.45354202
36IRAK31.44013495
37ADRBK21.43771686
38PLK31.38038878
39MKNK11.29913780
40LIMK11.28526128
41WEE11.27572573
42OBSCN1.26618031
43FRK1.26607987
44SRPK11.23536123
45GRK71.22347311
46CDK191.20187623
47TESK21.13300338
48ARAF1.12808096
49BMPR21.12706004
50CLK11.11887425
51MAP3K141.10701824
52ERBB31.10212800
53TAF11.06863814
54PIK3CG1.02661286
55EIF2AK11.01209170
56PDK20.99120643
57TRIM280.98162785
58KDR0.98104235
59EIF2AK20.95358048
60CSNK1G20.93781504
61TRPM70.92041562
62PASK0.91508763
63ABL20.90993338
64MKNK20.90929766
65RPS6KA50.90401004
66PNCK0.90264812
67WNK40.90111889
68RIPK40.88613241
69EPHB20.84718285
70BTK0.83055318
71STK38L0.82759511
72PLK20.81979027
73PLK10.81463608
74YES10.80554908
75MAP2K70.79010568
76AURKB0.78715332
77PKN10.78003138
78DYRK20.77805425
79KIT0.77773710
80IKBKB0.72200265
81CSNK1G30.71532561
82PLK40.70059811
83CCNB10.70049909
84MAP3K40.69232547
85CSNK1A1L0.67962978
86LYN0.67683734
87CAMK2B0.66920728
88PAK30.66407320
89TESK10.66052192
90MST1R0.64294781
91MAPK130.64102141
92ILK0.64073111
93CAMK2D0.63959768
94EPHB10.63686991
95ITK0.62791374
96PRKCG0.60994527
97TSSK60.59663544
98MAP4K10.58774184
99SYK0.56931505
100NLK0.56306095
101DAPK30.55777927
102LCK0.55344589
103FGR0.55260504
104PRKCQ0.54405421
105IRAK10.54352332
106NUAK10.54218301
107TIE10.53660478
108CHEK20.52568320
109ROCK20.52273765
110ADRBK10.51343136
111IRAK20.50771864
112CSNK2A10.50696008
113BRSK20.50617377
114TTK0.49841237
115MAPK40.49678503
116STK40.48955081
117TGFBR10.48157704
118CAMK2A0.47963801
119PIK3CA0.47936276
120IKBKE0.47329174
121PRKACA0.46026406
122NEK60.45626688
123MAPK150.45169734
124CAMK2G0.44370008
125CSNK1G10.43633408
126MAP3K30.42900451
127CSNK1A10.42418671
128GRK50.41698912
129GRK10.41251632
130PRKG10.40453037
131CSNK2A20.40070650
132AURKA0.39701764
133DYRK30.39071348
134PRKCE0.39001846
135PRKACB0.38129500
136CDK80.37384125
137MET0.37040742
138CSNK1E0.36351374
139CDK30.36169092
140STK240.35939461
141UHMK10.35851399
142MAPKAPK20.35789073
143MAP2K20.35742072
144RPS6KB20.35328785

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.12000356
2Oxidative phosphorylation_Homo sapiens_hsa001904.94359508
3Parkinsons disease_Homo sapiens_hsa050124.18583735
4Proteasome_Homo sapiens_hsa030503.81471228
5Protein export_Homo sapiens_hsa030603.49475830
6Alzheimers disease_Homo sapiens_hsa050103.19563779
7RNA polymerase_Homo sapiens_hsa030203.07385037
8Huntingtons disease_Homo sapiens_hsa050163.00445671
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.74823219
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91532118
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87726075
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86559007
13Fatty acid elongation_Homo sapiens_hsa000621.79600362
14Pyrimidine metabolism_Homo sapiens_hsa002401.77858295
15DNA replication_Homo sapiens_hsa030301.77420364
16Homologous recombination_Homo sapiens_hsa034401.74370298
17Cardiac muscle contraction_Homo sapiens_hsa042601.63481717
18Graft-versus-host disease_Homo sapiens_hsa053321.40869281
19Mismatch repair_Homo sapiens_hsa034301.40858512
20Steroid biosynthesis_Homo sapiens_hsa001001.37789831
21Spliceosome_Homo sapiens_hsa030401.35661360
22Propanoate metabolism_Homo sapiens_hsa006401.34221550
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32498211
24Nucleotide excision repair_Homo sapiens_hsa034201.31593620
25Asthma_Homo sapiens_hsa053101.29825970
26Allograft rejection_Homo sapiens_hsa053301.29779843
27Ether lipid metabolism_Homo sapiens_hsa005651.28500678
28Arachidonic acid metabolism_Homo sapiens_hsa005901.21237795
29Rheumatoid arthritis_Homo sapiens_hsa053231.15418447
30One carbon pool by folate_Homo sapiens_hsa006701.12903867
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12711719
32Non-homologous end-joining_Homo sapiens_hsa034501.09362925
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.09306071
34Purine metabolism_Homo sapiens_hsa002301.08986363
35Autoimmune thyroid disease_Homo sapiens_hsa053201.08330271
36Sphingolipid metabolism_Homo sapiens_hsa006001.04502930
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04458638
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02785249
39Basal transcription factors_Homo sapiens_hsa030221.02751158
40Base excision repair_Homo sapiens_hsa034101.01969225
41Butanoate metabolism_Homo sapiens_hsa006501.00607662
42Pyruvate metabolism_Homo sapiens_hsa006201.00200395
43Glutathione metabolism_Homo sapiens_hsa004800.99453508
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94844313
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94720903
46RNA degradation_Homo sapiens_hsa030180.90640957
47Linoleic acid metabolism_Homo sapiens_hsa005910.90626805
48Collecting duct acid secretion_Homo sapiens_hsa049660.89926786
49Fanconi anemia pathway_Homo sapiens_hsa034600.89673632
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89252184
51Sulfur metabolism_Homo sapiens_hsa009200.87241117
52Malaria_Homo sapiens_hsa051440.83690072
53Hematopoietic cell lineage_Homo sapiens_hsa046400.80917611
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80412901
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.78770780
56Phagosome_Homo sapiens_hsa041450.77464810
57Vibrio cholerae infection_Homo sapiens_hsa051100.75035563
58Tryptophan metabolism_Homo sapiens_hsa003800.74664596
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73248170
60Primary immunodeficiency_Homo sapiens_hsa053400.72829844
61Metabolic pathways_Homo sapiens_hsa011000.71627791
62Other glycan degradation_Homo sapiens_hsa005110.71365822
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69625088
64Nitrogen metabolism_Homo sapiens_hsa009100.68895709
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65526273
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64353366
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.63831916
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63174145
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62237203
70Systemic lupus erythematosus_Homo sapiens_hsa053220.59829885
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58466393
72Pertussis_Homo sapiens_hsa051330.58273061
73Sulfur relay system_Homo sapiens_hsa041220.57812152
74Histidine metabolism_Homo sapiens_hsa003400.57472019
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56727902
76Selenocompound metabolism_Homo sapiens_hsa004500.55005689
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.53415387
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52673460
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51363473
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50956488
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50166257
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.49834797
83Leishmaniasis_Homo sapiens_hsa051400.48918096
84beta-Alanine metabolism_Homo sapiens_hsa004100.47513302
85Circadian rhythm_Homo sapiens_hsa047100.46380984
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46130625
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.46008652
88Epstein-Barr virus infection_Homo sapiens_hsa051690.45916959
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45242556
90Phototransduction_Homo sapiens_hsa047440.44192491
91Fatty acid degradation_Homo sapiens_hsa000710.42919955
92Carbon metabolism_Homo sapiens_hsa012000.42077290
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41087252
94RNA transport_Homo sapiens_hsa030130.38748535
95Type I diabetes mellitus_Homo sapiens_hsa049400.37929734
96Mineral absorption_Homo sapiens_hsa049780.37929709
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37839796
98Measles_Homo sapiens_hsa051620.37297032
99Nicotine addiction_Homo sapiens_hsa050330.37191054
100Vitamin digestion and absorption_Homo sapiens_hsa049770.37024124
101Folate biosynthesis_Homo sapiens_hsa007900.36892118
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35735471
103Salmonella infection_Homo sapiens_hsa051320.35436217
104Legionellosis_Homo sapiens_hsa051340.35388957
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35122162
106Serotonergic synapse_Homo sapiens_hsa047260.34515936
107Caffeine metabolism_Homo sapiens_hsa002320.34363893
108African trypanosomiasis_Homo sapiens_hsa051430.32245393
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31556024
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30456927
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30330602
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29614331
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29110139
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28461929
115Antigen processing and presentation_Homo sapiens_hsa046120.26491053
116Oocyte meiosis_Homo sapiens_hsa041140.26125360
117p53 signaling pathway_Homo sapiens_hsa041150.24925793
118Regulation of autophagy_Homo sapiens_hsa041400.24080148
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23471996
120Basal cell carcinoma_Homo sapiens_hsa052170.23425558
121Fatty acid metabolism_Homo sapiens_hsa012120.22758596
122Phenylalanine metabolism_Homo sapiens_hsa003600.22340190
123Chemical carcinogenesis_Homo sapiens_hsa052040.22063159
124Hedgehog signaling pathway_Homo sapiens_hsa043400.21121212
125Olfactory transduction_Homo sapiens_hsa047400.20985735
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.20170928
127N-Glycan biosynthesis_Homo sapiens_hsa005100.20093912
128Herpes simplex infection_Homo sapiens_hsa051680.19530186
129Lysosome_Homo sapiens_hsa041420.18788537
130Tuberculosis_Homo sapiens_hsa051520.18749426
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18295443
132Vitamin B6 metabolism_Homo sapiens_hsa007500.17327473
133Tyrosine metabolism_Homo sapiens_hsa003500.15664659
134Arginine and proline metabolism_Homo sapiens_hsa003300.15502767
135Shigellosis_Homo sapiens_hsa051310.13627845
136Cell cycle_Homo sapiens_hsa041100.13460202
137Renin-angiotensin system_Homo sapiens_hsa046140.12745072
138Pentose phosphate pathway_Homo sapiens_hsa000300.10296677
139Peroxisome_Homo sapiens_hsa041460.09676643
140Retinol metabolism_Homo sapiens_hsa008300.09214046

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