MRPL35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.02746268
2DNA deamination (GO:0045006)4.78878723
3rRNA modification (GO:0000154)4.64069333
4transcription elongation from RNA polymerase III promoter (GO:0006385)4.36101588
5termination of RNA polymerase III transcription (GO:0006386)4.36101588
6telomere maintenance via semi-conservative replication (GO:0032201)4.25120817
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11261331
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10580964
9oxidative phosphorylation (GO:0006119)4.09785127
10ribosomal large subunit biogenesis (GO:0042273)4.07584115
11regulation of mitochondrial translation (GO:0070129)4.06083799
12CENP-A containing nucleosome assembly (GO:0034080)4.03036089
13telomere maintenance via recombination (GO:0000722)4.02740697
14ribosomal small subunit assembly (GO:0000028)3.99755483
15DNA strand elongation involved in DNA replication (GO:0006271)3.96573419
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91661650
17chromatin remodeling at centromere (GO:0031055)3.90150679
18DNA replication checkpoint (GO:0000076)3.88432156
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87593807
207-methylguanosine mRNA capping (GO:0006370)3.87511561
21rRNA methylation (GO:0031167)3.87351070
22tricarboxylic acid cycle (GO:0006099)3.86997377
23cullin deneddylation (GO:0010388)3.85452755
24maturation of SSU-rRNA (GO:0030490)3.83249300
25RNA capping (GO:0036260)3.82979901
267-methylguanosine RNA capping (GO:0009452)3.82979901
27regulation of cellular amino acid metabolic process (GO:0006521)3.81504014
28protein localization to kinetochore (GO:0034501)3.80953448
29purine nucleobase biosynthetic process (GO:0009113)3.80731343
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80627611
31ribosome assembly (GO:0042255)3.79849105
32DNA strand elongation (GO:0022616)3.77614196
33ATP synthesis coupled proton transport (GO:0015986)3.77451561
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77451561
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72777897
36protein localization to chromosome, centromeric region (GO:0071459)3.72550775
37spliceosomal snRNP assembly (GO:0000387)3.71309135
38ribonucleoprotein complex biogenesis (GO:0022613)3.70787721
39protein deneddylation (GO:0000338)3.70636557
40metaphase plate congression (GO:0051310)3.70350349
41ribosome biogenesis (GO:0042254)3.69449279
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69245589
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69245589
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69245589
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68924726
46negative regulation of ligase activity (GO:0051352)3.68924726
47transcription from mitochondrial promoter (GO:0006390)3.68011792
48NADH metabolic process (GO:0006734)3.67058148
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66145906
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66145906
51nucleobase biosynthetic process (GO:0046112)3.65862881
52deoxyribonucleotide biosynthetic process (GO:0009263)3.65666645
53DNA replication initiation (GO:0006270)3.64363727
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.64097381
55NADH dehydrogenase complex assembly (GO:0010257)3.64097381
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64097381
57pseudouridine synthesis (GO:0001522)3.63672448
58nucleobase-containing small molecule interconversion (GO:0015949)3.63182234
59mitotic chromosome condensation (GO:0007076)3.62948922
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62223743
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.58006784
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57837181
63transcription-coupled nucleotide-excision repair (GO:0006283)3.57584439
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56996325
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.56996325
66mitotic recombination (GO:0006312)3.55667125
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.53728162
68kinetochore assembly (GO:0051382)3.53666949
69termination of RNA polymerase I transcription (GO:0006363)3.50347127
70transcription from RNA polymerase I promoter (GO:0006360)3.50345003
71protein complex biogenesis (GO:0070271)3.50011022
72telomere maintenance via telomere lengthening (GO:0010833)3.48608148
73ribosomal small subunit biogenesis (GO:0042274)3.46908724
74rRNA processing (GO:0006364)3.46106171
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45847503
76mitotic sister chromatid segregation (GO:0000070)3.45086196
77cellular component biogenesis (GO:0044085)3.44558618
78maturation of 5.8S rRNA (GO:0000460)3.44114475
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43643554
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41754050
81kinetochore organization (GO:0051383)3.41499544
82nuclear pore complex assembly (GO:0051292)3.40351450
83establishment of viral latency (GO:0019043)3.39830314
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35954997
85rRNA metabolic process (GO:0016072)3.33075442
86deoxyribose phosphate biosynthetic process (GO:0046385)3.32835040
872-deoxyribonucleotide biosynthetic process (GO:0009265)3.32835040
88regulation of translational fidelity (GO:0006450)3.32691146
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.28343510
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28302813
91mitochondrial respiratory chain complex assembly (GO:0033108)3.27928571
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27746816
93positive regulation of ligase activity (GO:0051351)3.25316731
94protein targeting to mitochondrion (GO:0006626)3.24584382
95spindle checkpoint (GO:0031577)3.24422527
96protein neddylation (GO:0045116)3.24204939
97* translation (GO:0006412)3.23885954
98sister chromatid segregation (GO:0000819)3.23202606
99IMP biosynthetic process (GO:0006188)3.23141175
100GTP biosynthetic process (GO:0006183)3.22990811
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22238269
102formation of translation preinitiation complex (GO:0001731)3.21521279
103IMP metabolic process (GO:0046040)3.21291556
104mitotic metaphase plate congression (GO:0007080)3.20268535
105spliceosomal complex assembly (GO:0000245)3.19121288
106tRNA aminoacylation for protein translation (GO:0006418)3.19012131
107DNA replication-independent nucleosome organization (GO:0034724)3.17735609
108DNA replication-independent nucleosome assembly (GO:0006336)3.17735609
109nuclear pore organization (GO:0006999)3.16694391
110histone exchange (GO:0043486)3.15781937
111respiratory electron transport chain (GO:0022904)3.15697850
112chaperone-mediated protein transport (GO:0072321)3.15294654
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.15101521
114tRNA aminoacylation (GO:0043039)3.14421461
115amino acid activation (GO:0043038)3.14421461
116establishment of chromosome localization (GO:0051303)3.13817682
117guanosine-containing compound biosynthetic process (GO:1901070)3.13737273
118respiratory chain complex IV assembly (GO:0008535)3.13541248
119establishment of integrated proviral latency (GO:0075713)3.13439273
120establishment of protein localization to mitochondrion (GO:0072655)3.12954427
121G1/S transition of mitotic cell cycle (GO:0000082)3.10978119
122cell cycle G1/S phase transition (GO:0044843)3.10978119
123electron transport chain (GO:0022900)3.06466784
124mitotic nuclear envelope disassembly (GO:0007077)3.05713149
125regulation of ubiquitin-protein transferase activity (GO:0051438)3.04229863
126regulation of spindle organization (GO:0090224)3.03703374
127mitotic spindle checkpoint (GO:0071174)3.00697171
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00607804
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00607804
130negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00607804
131negative regulation of mitotic sister chromatid separation (GO:2000816)3.00607804
132negative regulation of sister chromatid segregation (GO:0033046)3.00607804
133regulation of mitotic spindle organization (GO:0060236)2.99278429
134regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.99031262
135mitochondrial RNA metabolic process (GO:0000959)2.98775313
136oxaloacetate metabolic process (GO:0006107)2.97835652
137negative regulation of chromosome segregation (GO:0051985)2.97281765
138protein localization to mitochondrion (GO:0070585)2.97030140
139spindle assembly checkpoint (GO:0071173)2.96315285
140mitotic spindle assembly checkpoint (GO:0007094)2.93176558
141regulation of ligase activity (GO:0051340)2.92185007
142DNA unwinding involved in DNA replication (GO:0006268)2.91762813
143regulation of chromosome segregation (GO:0051983)2.89464080
144protein complex localization (GO:0031503)2.87342420
145regulation of cofactor metabolic process (GO:0051193)2.84874666
146regulation of coenzyme metabolic process (GO:0051196)2.84874666
147pteridine-containing compound biosynthetic process (GO:0042559)2.84048007
148DNA ligation (GO:0006266)2.82936999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57717604
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.98624871
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.22045457
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.15936141
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.99228712
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.98493870
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.49687469
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23867296
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21687101
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20708395
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14557886
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12837666
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07536331
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99698015
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94542465
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94183179
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80597214
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80237093
19* VDR_23849224_ChIP-Seq_CD4+_Human2.70108577
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59162532
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58076479
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57051456
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54994976
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.48855551
25DCP1A_22483619_ChIP-Seq_HELA_Human2.30578344
26FOXP3_21729870_ChIP-Seq_TREG_Human2.30388475
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.24944399
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24112696
29ELK1_19687146_ChIP-ChIP_HELA_Human2.19951270
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18358474
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16481485
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09572603
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09098370
34* XRN2_22483619_ChIP-Seq_HELA_Human2.03556351
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95434014
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91986025
37GABP_19822575_ChIP-Seq_HepG2_Human1.90910539
38TTF2_22483619_ChIP-Seq_HELA_Human1.90436854
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86263585
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85033181
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76916657
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76526756
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76213482
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75237843
45ZNF263_19887448_ChIP-Seq_K562_Human1.70016688
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66344290
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.65346231
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64290810
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59322854
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53445963
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50915478
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.47573495
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47038628
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41840331
55AR_21909140_ChIP-Seq_LNCAP_Human1.40118656
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39855267
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36313112
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36213731
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35363922
60MYC_18940864_ChIP-ChIP_HL60_Human1.34555053
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.31263715
62* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30248802
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27951394
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.27565076
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25047865
66IRF1_19129219_ChIP-ChIP_H3396_Human1.15848046
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15374311
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.14714982
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14325532
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11186770
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08520023
72CIITA_25753668_ChIP-Seq_RAJI_Human1.07873309
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06345416
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05602469
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05210477
76* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01821913
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99944081
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99394232
79TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98900574
80KDM5A_27292631_Chip-Seq_BREAST_Human0.98690847
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97724031
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96089995
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95593785
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94254252
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92322459
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91872670
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90367904
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90265368
89BP1_19119308_ChIP-ChIP_Hs578T_Human0.88364543
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87156147
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85770907
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85015563
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84161205
94* SOX17_20123909_ChIP-Seq_XEN_Mouse0.84056481
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82521479
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82484124
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82200424
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81763652
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.81084864
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.80489149
101SPI1_23547873_ChIP-Seq_NB4_Human0.79640620
102* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79625194
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79465131
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79259243
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78651270
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.78595330
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77290670
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77223996
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76502255
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75982736
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75307340
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74823586
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.74691766
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74230840
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.74214176
116FUS_26573619_Chip-Seq_HEK293_Human0.73839214
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73501039
118HTT_18923047_ChIP-ChIP_STHdh_Human0.71688111
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70831546
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69574318
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69293464
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69259952
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.68876952
124ELF5_23300383_ChIP-Seq_T47D_Human0.68693880
125EWS_26573619_Chip-Seq_HEK293_Human0.63791817
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.63396534
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.63364262
128TFEB_21752829_ChIP-Seq_HELA_Human0.61648304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08039213
2MP0010094_abnormal_chromosome_stability4.05400860
3MP0008058_abnormal_DNA_repair3.97838190
4MP0004957_abnormal_blastocyst_morpholog3.71329592
5MP0008057_abnormal_DNA_replication3.59441068
6MP0003111_abnormal_nucleus_morphology3.53457995
7MP0003077_abnormal_cell_cycle3.08752668
8MP0008932_abnormal_embryonic_tissue2.78155197
9MP0008877_abnormal_DNA_methylation2.64617081
10MP0008007_abnormal_cellular_replicative2.63834274
11MP0003806_abnormal_nucleotide_metabolis2.63623534
12MP0009379_abnormal_foot_pigmentation2.49458493
13MP0003786_premature_aging2.48364129
14MP0000751_myopathy2.48164532
15MP0001986_abnormal_taste_sensitivity2.47666484
16MP0003186_abnormal_redox_activity2.44486424
17MP0003718_maternal_effect2.44385686
18MP0002132_abnormal_respiratory_system2.29192589
19MP0006292_abnormal_olfactory_placode2.16702981
20MP0005330_cardiomyopathy2.14586016
21MP0001188_hyperpigmentation2.11992255
22MP0004084_abnormal_cardiac_muscle2.09137587
23MP0004145_abnormal_muscle_electrophysio2.09083462
24MP0002877_abnormal_melanocyte_morpholog2.02717835
25MP0009697_abnormal_copulation2.02542149
26MP0002837_dystrophic_cardiac_calcinosis2.00570886
27MP0006036_abnormal_mitochondrial_physio1.93201270
28MP0004036_abnormal_muscle_relaxation1.87926526
29MP0004233_abnormal_muscle_weight1.87532280
30MP0002396_abnormal_hematopoietic_system1.76626984
31MP0006035_abnormal_mitochondrial_morpho1.75562332
32MP0003646_muscle_fatigue1.73974393
33MP0004147_increased_porphyrin_level1.69774435
34MP0008260_abnormal_autophagy1.64969974
35MP0002269_muscular_atrophy1.63952248
36MP0001529_abnormal_vocalization1.62654130
37MP0001764_abnormal_homeostasis1.62479002
38MP0000747_muscle_weakness1.59264779
39MP0002638_abnormal_pupillary_reflex1.55144338
40MP0003221_abnormal_cardiomyocyte_apopto1.50998812
41MP0003136_yellow_coat_color1.49558417
42MP0001853_heart_inflammation1.47610989
43MP0002160_abnormal_reproductive_system1.45880552
44MP0000372_irregular_coat_pigmentation1.45129507
45MP0003123_paternal_imprinting1.39270674
46MP0001697_abnormal_embryo_size1.37268880
47MP0003315_abnormal_perineum_morphology1.35599769
48MP0003941_abnormal_skin_development1.33523677
49MP0002210_abnormal_sex_determination1.32520638
50MP0004087_abnormal_muscle_fiber1.31309996
51MP0005075_abnormal_melanosome_morpholog1.31252554
52MP0001835_abnormal_antigen_presentation1.28852817
53MP0000490_abnormal_crypts_of1.28375120
54MP0002822_catalepsy1.27719128
55MP0005389_reproductive_system_phenotype1.26817859
56MP0002163_abnormal_gland_morphology1.25533856
57MP0005380_embryogenesis_phenotype1.25382687
58MP0001672_abnormal_embryogenesis/_devel1.25382687
59MP0009333_abnormal_splenocyte_physiolog1.24347537
60MP0002234_abnormal_pharynx_morphology1.21495752
61MP0002277_abnormal_respiratory_mucosa1.21402464
62MP0004270_analgesia1.21025392
63MP0002972_abnormal_cardiac_muscle1.18187052
64MP0000759_abnormal_skeletal_muscle1.15137999
65MP0000015_abnormal_ear_pigmentation1.14948104
66MP0003656_abnormal_erythrocyte_physiolo1.14802013
67MP0003984_embryonic_growth_retardation1.14561694
68MP0002148_abnormal_hypersensitivity_rea1.12921989
69MP0003950_abnormal_plasma_membrane1.12422424
70MP0010234_abnormal_vibrissa_follicle1.10565439
71MP0002876_abnormal_thyroid_physiology1.09582223
72MP0000350_abnormal_cell_proliferation1.08581159
73MP0002106_abnormal_muscle_physiology1.08484156
74MP0003137_abnormal_impulse_conducting1.08375107
75MP0001929_abnormal_gametogenesis1.08243167
76MP0002088_abnormal_embryonic_growth/wei1.07808679
77MP0002095_abnormal_skin_pigmentation1.07188283
78MP0001661_extended_life_span1.06355123
79MP0009046_muscle_twitch1.05173017
80MP0006276_abnormal_autonomic_nervous1.04514753
81MP0001145_abnormal_male_reproductive1.04285714
82MP0002102_abnormal_ear_morphology1.04233641
83MP0001905_abnormal_dopamine_level1.03758233
84MP0005187_abnormal_penis_morphology1.03618667
85MP0000313_abnormal_cell_death1.03097047
86MP0001119_abnormal_female_reproductive1.01108698
87MP0001919_abnormal_reproductive_system1.00425993
88MP0008775_abnormal_heart_ventricle1.00173205
89MP0001544_abnormal_cardiovascular_syste0.99384105
90MP0005385_cardiovascular_system_phenoty0.99384105
91MP0005620_abnormal_muscle_contractility0.97718336
92MP0005408_hypopigmentation0.97488278
93MP0009672_abnormal_birth_weight0.97357255
94MP0000653_abnormal_sex_gland0.97260834
95MP0003724_increased_susceptibility_to0.95844265
96MP0000750_abnormal_muscle_regeneration0.94333722
97MP0010352_gastrointestinal_tract_polyps0.93053588
98MP0004142_abnormal_muscle_tone0.92482232
99MP0002084_abnormal_developmental_patter0.92179838
100MP0002085_abnormal_embryonic_tissue0.91453930
101MP0005671_abnormal_response_to0.91431906
102MP0001730_embryonic_growth_arrest0.88651781
103MP0001542_abnormal_bone_strength0.86006987
104MP0005266_abnormal_metabolism0.85436559
105MP0005369_muscle_phenotype0.84754310
106MP0000358_abnormal_cell_content/0.83590616
107MP0009785_altered_susceptibility_to0.83421063
108MP0006138_congestive_heart_failure0.83326661
109MP0009780_abnormal_chondrocyte_physiolo0.82954397
110MP0001727_abnormal_embryo_implantation0.82708679
111MP0005332_abnormal_amino_acid0.82481931
112MP0001984_abnormal_olfaction0.82341707
113MP0010630_abnormal_cardiac_muscle0.81793148
114MP0002751_abnormal_autonomic_nervous0.80129033
115MP0005171_absent_coat_pigmentation0.79110432
116MP0001299_abnormal_eye_distance/0.78899550
117MP0002019_abnormal_tumor_incidence0.78729737
118MP0005670_abnormal_white_adipose0.77157847
119MP0004197_abnormal_fetal_growth/weight/0.76705266
120MP0002086_abnormal_extraembryonic_tissu0.75946356
121MP0003567_abnormal_fetal_cardiomyocyte0.75287395
122MP0008995_early_reproductive_senescence0.74818976
123MP0004215_abnormal_myocardial_fiber0.74772509
124MP0003890_abnormal_embryonic-extraembry0.74070527
125MP0005501_abnormal_skin_physiology0.73639984
126MP0004484_altered_response_of0.73443289
127MP0005379_endocrine/exocrine_gland_phen0.72610443
128MP0000566_synostosis0.72159342
129MP0003698_abnormal_male_reproductive0.71581766
130MP0000749_muscle_degeneration0.70638166
131MP0006072_abnormal_retinal_apoptosis0.70430390
132MP0005451_abnormal_body_composition0.70166066
133MP0000689_abnormal_spleen_morphology0.69998736
134MP0002233_abnormal_nose_morphology0.68159240
135MP0005084_abnormal_gallbladder_morpholo0.67692340
136MP0010307_abnormal_tumor_latency0.67678897
137MP0004782_abnormal_surfactant_physiolog0.67110544
138MP0010386_abnormal_urinary_bladder0.66971413
139MP0002722_abnormal_immune_system0.66832812
140MP0002736_abnormal_nociception_after0.66709546
141MP0002398_abnormal_bone_marrow0.66638571
142MP0001545_abnormal_hematopoietic_system0.66388697
143MP0005397_hematopoietic_system_phenotyp0.66388697
144MP0004085_abnormal_heartbeat0.66277384
145MP0002127_abnormal_cardiovascular_syste0.65771791
146MP0003763_abnormal_thymus_physiology0.64874426
147MP0002938_white_spotting0.64032789
148MP0005376_homeostasis/metabolism_phenot0.63968081
149MP0000647_abnormal_sebaceous_gland0.63523295
150MP0002735_abnormal_chemical_nociception0.63302729
151MP0001293_anophthalmia0.62628651
152MP0005410_abnormal_fertilization0.62376155
153MP0003385_abnormal_body_wall0.62369034
154MP0001186_pigmentation_phenotype0.61419853
155MP0000762_abnormal_tongue_morphology0.61240131
156MP0002080_prenatal_lethality0.59655905
157MP0005395_other_phenotype0.58645300
158MP0003011_delayed_dark_adaptation0.57825518
159MP0003121_genomic_imprinting0.57647473
160MP0004133_heterotaxia0.57163739
161MP0002429_abnormal_blood_cell0.56701008

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.65787147
2Mitochondrial inheritance (HP:0001427)4.42463228
3Abnormal mitochondria in muscle tissue (HP:0008316)4.17323965
4Increased CSF lactate (HP:0002490)4.13973374
5Hepatocellular necrosis (HP:0001404)4.09891719
6Birth length less than 3rd percentile (HP:0003561)3.94613313
7Increased hepatocellular lipid droplets (HP:0006565)3.87110590
8Muscle fiber inclusion bodies (HP:0100299)3.83459444
9Chromsome breakage (HP:0040012)3.82572049
10Nemaline bodies (HP:0003798)3.82023177
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.79211945
12Acute encephalopathy (HP:0006846)3.78488019
13Progressive macrocephaly (HP:0004481)3.75665972
14Exercise-induced muscle cramps (HP:0003710)3.74698353
153-Methylglutaconic aciduria (HP:0003535)3.70557806
16Hepatic necrosis (HP:0002605)3.70121278
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65472164
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62805772
19Increased serum lactate (HP:0002151)3.57587753
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.48114087
21Lipid accumulation in hepatocytes (HP:0006561)3.44507059
22Reticulocytopenia (HP:0001896)3.42220419
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35815098
24Abnormality of alanine metabolism (HP:0010916)3.35815098
25Hyperalaninemia (HP:0003348)3.35815098
26Abnormality of cells of the erythroid lineage (HP:0012130)3.33809844
27Abnormal number of erythroid precursors (HP:0012131)3.30666308
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19418594
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19418594
30Oral leukoplakia (HP:0002745)3.16679917
31Renal Fanconi syndrome (HP:0001994)3.04743698
32Aplastic anemia (HP:0001915)3.04727455
33Lactic acidosis (HP:0003128)2.99702390
34Exertional dyspnea (HP:0002875)2.98519287
35Rhabdomyolysis (HP:0003201)2.96096295
36Breast hypoplasia (HP:0003187)2.95980437
37Microvesicular hepatic steatosis (HP:0001414)2.93485102
38Exercise intolerance (HP:0003546)2.90976103
39Multiple enchondromatosis (HP:0005701)2.89963351
40Abnormality of the preputium (HP:0100587)2.84398080
41Abnormality of glycolysis (HP:0004366)2.83893555
42Increased serum pyruvate (HP:0003542)2.83893555
43Type I transferrin isoform profile (HP:0003642)2.83403124
44Rough bone trabeculation (HP:0100670)2.80237514
45Respiratory failure (HP:0002878)2.75317583
46Duplicated collecting system (HP:0000081)2.74901714
47Palpitations (HP:0001962)2.74715857
48Rimmed vacuoles (HP:0003805)2.68051483
49Progressive muscle weakness (HP:0003323)2.66985503
50Myoglobinuria (HP:0002913)2.64226333
51Cerebral hypomyelination (HP:0006808)2.64067407
52Cerebral edema (HP:0002181)2.62423368
53Respiratory difficulties (HP:0002880)2.59010862
54Increased intramyocellular lipid droplets (HP:0012240)2.55251388
55Abnormality of the renal collecting system (HP:0004742)2.54965439
56Ragged-red muscle fibers (HP:0003200)2.54612444
57Carpal bone hypoplasia (HP:0001498)2.53964070
58Abnormality of methionine metabolism (HP:0010901)2.48247547
59Meckel diverticulum (HP:0002245)2.46062748
60Macrocytic anemia (HP:0001972)2.43976465
61Pancytopenia (HP:0001876)2.39747603
62Sudden death (HP:0001699)2.39543473
63EMG: myopathic abnormalities (HP:0003458)2.38405456
64Pallor (HP:0000980)2.35497000
65Degeneration of anterior horn cells (HP:0002398)2.35368028
66Abnormality of the anterior horn cell (HP:0006802)2.35368028
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.32751341
68Abnormality of chromosome stability (HP:0003220)2.32346069
69Exercise-induced myalgia (HP:0003738)2.30601192
70Abnormality of the ileum (HP:0001549)2.29434661
71Premature graying of hair (HP:0002216)2.29290472
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.28272519
73Optic disc pallor (HP:0000543)2.28096026
74Abnormal trabecular bone morphology (HP:0100671)2.27431704
75Cholecystitis (HP:0001082)2.27328367
76Abnormal gallbladder physiology (HP:0012438)2.27328367
77Impulsivity (HP:0100710)2.25606361
78Bundle branch block (HP:0011710)2.23501802
79Subaortic stenosis (HP:0001682)2.20433685
80Abnormality of the left ventricular outflow tract (HP:0011103)2.20433685
81Megaloblastic anemia (HP:0001889)2.19432213
82Absent thumb (HP:0009777)2.17227744
83Reduced antithrombin III activity (HP:0001976)2.13446386
84Sparse eyelashes (HP:0000653)2.13354596
85Neuroendocrine neoplasm (HP:0100634)2.13107831
86Pheochromocytoma (HP:0002666)2.12505832
87Patellar aplasia (HP:0006443)2.10554338
88Bone marrow hypocellularity (HP:0005528)2.10455066
89Type 2 muscle fiber atrophy (HP:0003554)2.09682359
90Abnormality of renal resorption (HP:0011038)2.09614711
91Hypokinesia (HP:0002375)2.08814193
92Abnormal spermatogenesis (HP:0008669)2.08701649
93Increased muscle lipid content (HP:0009058)2.08587151
94CNS demyelination (HP:0007305)2.05066864
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.04444802
96Irregular epiphyses (HP:0010582)2.01151838
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00103686
98Leukodystrophy (HP:0002415)1.98914407
99Abnormality of placental membranes (HP:0011409)1.98309615
100Amniotic constriction ring (HP:0009775)1.98309615
101Poor head control (HP:0002421)1.96378335
102Neck muscle weakness (HP:0000467)1.95672543
103Aplasia/Hypoplasia of the patella (HP:0006498)1.94622914
104Absent radius (HP:0003974)1.94168427
105Tongue fasciculations (HP:0001308)1.92935880
106Neoplasm of the peripheral nervous system (HP:0100007)1.90601806
107Abnormality of serum amino acid levels (HP:0003112)1.90465253
108Neoplasm of the adrenal gland (HP:0100631)1.90160948
109Abnormality of the calf musculature (HP:0001430)1.89693540
110Pancreatic fibrosis (HP:0100732)1.89623247
111Progressive external ophthalmoplegia (HP:0000590)1.88886622
112Horseshoe kidney (HP:0000085)1.88449118
113Secondary amenorrhea (HP:0000869)1.88238286
114Abnormality of pyrimidine metabolism (HP:0004353)1.88135528
115Muscle hypertrophy of the lower extremities (HP:0008968)1.87734587
116Gout (HP:0001997)1.87154900
117Abnormal lung lobation (HP:0002101)1.87048021
118Calf muscle hypertrophy (HP:0008981)1.86484069
119Muscle fiber atrophy (HP:0100295)1.85257246
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85145432
121Cleft eyelid (HP:0000625)1.84809551
122Metabolic acidosis (HP:0001942)1.84070133
123Nausea (HP:0002018)1.83490825
124Triphalangeal thumb (HP:0001199)1.82801117
125Unsteady gait (HP:0002317)1.82348338
126Premature ovarian failure (HP:0008209)1.82193389
127Cortical dysplasia (HP:0002539)1.80292794
128Pancreatic cysts (HP:0001737)1.79693373
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79665990
130Abnormality of DNA repair (HP:0003254)1.79592769
131Lethargy (HP:0001254)1.79388982
132Aplasia involving forearm bones (HP:0009822)1.77958689
133Absent forearm bone (HP:0003953)1.77958689
134Hyperglycinemia (HP:0002154)1.75758005
135Type 1 muscle fiber predominance (HP:0003803)1.75520810
136Abnormal protein glycosylation (HP:0012346)1.75318906
137Abnormal glycosylation (HP:0012345)1.75318906
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75318906
139Abnormal protein N-linked glycosylation (HP:0012347)1.75318906
140True hermaphroditism (HP:0010459)1.74587319
141Congenital, generalized hypertrichosis (HP:0004540)1.74570723
142Shoulder girdle muscle weakness (HP:0003547)1.71307666
143Redundant skin (HP:0001582)1.68183311
144Increased nuchal translucency (HP:0010880)1.68067399
145Abnormality of the intrinsic pathway (HP:0010989)1.67697190
146Hyperglycinuria (HP:0003108)1.67413994
147Muscle stiffness (HP:0003552)1.65476127
148Dilated cardiomyopathy (HP:0001644)1.65191852
149Postnatal microcephaly (HP:0005484)1.64241467
150Hypobetalipoproteinemia (HP:0003563)1.63492590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.18771537
2BUB13.92393472
3EIF2AK13.90678525
4WEE13.26393371
5NME22.92734498
6VRK22.86528958
7SRPK12.67894584
8PLK42.48807683
9VRK12.48571845
10ZAK2.39192047
11EIF2AK32.38449237
12SCYL22.06861515
13IRAK31.92734060
14BRSK21.83404023
15NME11.82269341
16MKNK21.75632295
17MAP3K121.71132579
18TLK11.68357294
19CDC71.67870736
20TSSK61.65970460
21PIM21.65396863
22ACVR1B1.59691466
23CASK1.58831777
24MST41.58256363
25IRAK41.58224726
26PBK1.55911268
27MKNK11.55301899
28TTK1.50575628
29EIF2AK21.49932098
30PLK31.44911760
31PLK11.43513727
32TAF11.35308445
33CCNB11.30942419
34BRAF1.15956162
35PHKG21.13967040
36PHKG11.13967040
37AKT31.04257387
38TESK21.03999225
39BRSK11.02182441
40AURKB1.01822869
41AURKA1.00754287
42NEK10.98631028
43ATR0.98359038
44STK38L0.97568300
45MAP2K70.95376321
46ADRBK20.95263725
47PDK20.93763902
48MAP4K20.93070655
49MUSK0.91377607
50CDK70.90658972
51CHEK20.90039872
52CDK80.89808478
53MYLK0.89776511
54STK390.88954740
55ERBB30.85279328
56MST1R0.84878990
57TXK0.84656966
58YES10.83792489
59ARAF0.81593263
60PAK40.80708769
61MAPKAPK30.77303933
62TEC0.76345871
63EEF2K0.76302652
64MAPKAPK50.75226914
65DYRK30.75071743
66BMPR20.75006925
67NEK20.74592720
68SIK30.74087213
69PDK40.72942114
70PDK30.72942114
71LATS20.72659381
72TTN0.71738883
73PNCK0.71570849
74CSNK2A10.71317470
75DYRK20.71269370
76ALK0.71091928
77GRK70.70517477
78NEK60.69858773
79OBSCN0.65895836
80STK240.65609828
81BCKDK0.64200203
82BMPR1B0.64085617
83CSNK1G10.63169841
84CSNK1G30.62956865
85AKT20.61665698
86MAP3K140.61658400
87PRPF4B0.61350771
88NEK90.59358326
89CSNK1A1L0.58805797
90OXSR10.58497678
91BCR0.58417058
92CSNK2A20.56077769
93PIK3CG0.55626610
94TRIM280.55383602
95TAOK20.53958716
96MET0.53753008
97ABL20.53592236
98TESK10.53308314
99IKBKB0.53130615
100MAP3K100.53004849
101STK40.52973765
102CAMK2D0.52581296
103CAMK2G0.52332862
104PLK20.51353625
105CSNK1G20.50372832
106CDK140.49859900
107PIM10.49268917
108ERBB40.49033136
109MAP3K110.48925550
110EPHA20.48147613
111NUAK10.47939439
112CHEK10.46763871
113BLK0.46705583
114PINK10.45119606
115DAPK30.44919027
116GRK10.44770650
117IRAK20.44583398
118KDR0.44010159
119CDK180.43841475
120TNIK0.43815377
121RPS6KA50.43670579
122MAP3K80.43415134
123ATM0.42732882
124PRKCI0.42451001
125ILK0.42334899
126CDK150.41458662
127CSNK1E0.41245533
128CDK11A0.40737643
129LIMK10.40484392
130IRAK10.39843482
131RPS6KB20.38234740
132PRKD30.37765307
133CDK10.36829428
134CAMK2B0.36629860
135KSR20.36457296
136MINK10.36013310
137DMPK0.35924400
138CDK30.35464584
139MAP3K50.35451158
140RPS6KA40.34953255
141LYN0.34246357
142RAF10.33031060
143RPS6KB10.32335975
144NLK0.28763067
145DAPK10.28395187

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.66404857
2RNA polymerase_Homo sapiens_hsa030203.92681929
3DNA replication_Homo sapiens_hsa030303.85864721
4* Ribosome_Homo sapiens_hsa030103.83539535
5Mismatch repair_Homo sapiens_hsa034303.30910814
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27481538
7Oxidative phosphorylation_Homo sapiens_hsa001903.01893504
8Homologous recombination_Homo sapiens_hsa034402.93217488
9Pyrimidine metabolism_Homo sapiens_hsa002402.78258393
10Parkinsons disease_Homo sapiens_hsa050122.69480508
11Nucleotide excision repair_Homo sapiens_hsa034202.58296882
12Spliceosome_Homo sapiens_hsa030402.49888430
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40096859
14Base excision repair_Homo sapiens_hsa034102.34777720
15Huntingtons disease_Homo sapiens_hsa050162.22319586
16Fanconi anemia pathway_Homo sapiens_hsa034602.16080347
17RNA transport_Homo sapiens_hsa030132.14521456
18Non-homologous end-joining_Homo sapiens_hsa034502.08665212
19Basal transcription factors_Homo sapiens_hsa030222.07561177
20Protein export_Homo sapiens_hsa030601.88471189
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88367732
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73734797
23One carbon pool by folate_Homo sapiens_hsa006701.69419068
24Purine metabolism_Homo sapiens_hsa002301.69048905
25Alzheimers disease_Homo sapiens_hsa050101.67726560
26RNA degradation_Homo sapiens_hsa030181.67584780
27Cell cycle_Homo sapiens_hsa041101.61246332
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53157710
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32809004
30Sulfur metabolism_Homo sapiens_hsa009201.28200029
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24358507
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16928130
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16523647
34Vitamin B6 metabolism_Homo sapiens_hsa007501.12105308
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08887317
36Arginine biosynthesis_Homo sapiens_hsa002201.07850703
37p53 signaling pathway_Homo sapiens_hsa041150.97207558
38Epstein-Barr virus infection_Homo sapiens_hsa051690.96035559
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93951773
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93822951
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91684216
42Folate biosynthesis_Homo sapiens_hsa007900.90855660
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.84103574
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83990598
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83837094
46Fatty acid metabolism_Homo sapiens_hsa012120.83520645
47Cardiac muscle contraction_Homo sapiens_hsa042600.81859163
48Glutathione metabolism_Homo sapiens_hsa004800.80094442
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79886694
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.78586826
51Metabolic pathways_Homo sapiens_hsa011000.74328913
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74178995
53Pentose phosphate pathway_Homo sapiens_hsa000300.73523844
54Arachidonic acid metabolism_Homo sapiens_hsa005900.72684570
55mRNA surveillance pathway_Homo sapiens_hsa030150.72671440
56Phenylalanine metabolism_Homo sapiens_hsa003600.70748074
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69568032
58Fatty acid degradation_Homo sapiens_hsa000710.69471739
59Sulfur relay system_Homo sapiens_hsa041220.67831039
60Systemic lupus erythematosus_Homo sapiens_hsa053220.64114449
61Regulation of autophagy_Homo sapiens_hsa041400.63080496
62Fatty acid elongation_Homo sapiens_hsa000620.55272255
63Carbon metabolism_Homo sapiens_hsa012000.55061450
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54992279
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54420224
66Fructose and mannose metabolism_Homo sapiens_hsa000510.53502600
67Allograft rejection_Homo sapiens_hsa053300.52633347
68Herpes simplex infection_Homo sapiens_hsa051680.50547549
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49625648
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48748764
71Butanoate metabolism_Homo sapiens_hsa006500.48302814
72Graft-versus-host disease_Homo sapiens_hsa053320.45834939
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44146492
74Autoimmune thyroid disease_Homo sapiens_hsa053200.42605713
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.42177712
76Vibrio cholerae infection_Homo sapiens_hsa051100.41285233
77beta-Alanine metabolism_Homo sapiens_hsa004100.40237667
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39650183
79Circadian rhythm_Homo sapiens_hsa047100.39176217
80Arginine and proline metabolism_Homo sapiens_hsa003300.38778809
81Legionellosis_Homo sapiens_hsa051340.38268311
82Biosynthesis of amino acids_Homo sapiens_hsa012300.37642739
83Asthma_Homo sapiens_hsa053100.36287404
84Oocyte meiosis_Homo sapiens_hsa041140.36128203
85Primary immunodeficiency_Homo sapiens_hsa053400.35842674
86Pyruvate metabolism_Homo sapiens_hsa006200.35406737
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34904673
88Propanoate metabolism_Homo sapiens_hsa006400.33949686
89Antigen processing and presentation_Homo sapiens_hsa046120.33476333
90Collecting duct acid secretion_Homo sapiens_hsa049660.32649237
91Mineral absorption_Homo sapiens_hsa049780.32392168
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.31123809
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31023734
94Linoleic acid metabolism_Homo sapiens_hsa005910.30107860
95N-Glycan biosynthesis_Homo sapiens_hsa005100.29234922
96Starch and sucrose metabolism_Homo sapiens_hsa005000.28758969
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28078166
98Vitamin digestion and absorption_Homo sapiens_hsa049770.27789462
99Galactose metabolism_Homo sapiens_hsa000520.25835408
100Sphingolipid metabolism_Homo sapiens_hsa006000.25764169
101Thyroid cancer_Homo sapiens_hsa052160.25732866
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25443227
103Peroxisome_Homo sapiens_hsa041460.25426044
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.25104053
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24699371
106Alcoholism_Homo sapiens_hsa050340.22924757
107Selenocompound metabolism_Homo sapiens_hsa004500.22552595
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22397045
109Synaptic vesicle cycle_Homo sapiens_hsa047210.21782717
110Rheumatoid arthritis_Homo sapiens_hsa053230.21314688
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20560021
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18876096
113Tyrosine metabolism_Homo sapiens_hsa003500.18699955
114Steroid biosynthesis_Homo sapiens_hsa001000.18642533
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18237115
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.17369287
117Measles_Homo sapiens_hsa051620.17302547
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17254226
119Other glycan degradation_Homo sapiens_hsa005110.16901354
120Dilated cardiomyopathy_Homo sapiens_hsa054140.16870529
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16233647
122Tight junction_Homo sapiens_hsa045300.15457985
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14380479
124Retinol metabolism_Homo sapiens_hsa008300.13576284
125Phagosome_Homo sapiens_hsa041450.13367828
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13357393
127Hematopoietic cell lineage_Homo sapiens_hsa046400.13082354
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.13013611
129Phototransduction_Homo sapiens_hsa047440.12864059
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11590019

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