ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	8.44163787
2	cell wall macromolecule metabolic process (GO:0044036)	7.63108895
3	pyrimidine-containing compound transmembrane transport (GO:0072531)	6.12484437
4	adenosine metabolic process (GO:0046085)	5.87158949
5	AMP metabolic process (GO:0046033)	5.60852919
6	purine nucleotide salvage (GO:0032261)	4.89573321
7	type B pancreatic cell proliferation (GO:0044342)	4.85559834
8	response to pheromone (GO:0019236)	4.73030414
9	water-soluble vitamin biosynthetic process (GO:0042364)	4.49725803
10	nucleoside transmembrane transport (GO:1901642)	4.29408605
11	piRNA metabolic process (GO:0034587)	4.07058475
12	synapsis (GO:0007129)	3.99294114
13	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.94329537
14	ADP metabolic process (GO:0046031)	3.93261467
15	purine-containing compound salvage (GO:0043101)	3.91994597
16	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.91391109
17	deoxyribose phosphate biosynthetic process (GO:0046385)	3.91391109
18	regulation of oxidative phosphorylation (GO:0002082)	3.89985619
19	vitamin transmembrane transport (GO:0035461)	3.88035849
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.73386840
21	tryptophan metabolic process (GO:0006568)	3.68449829
22	DNA methylation involved in gamete generation (GO:0043046)	3.64928775
23	indole-containing compound catabolic process (GO:0042436)	3.60791496
24	indolalkylamine catabolic process (GO:0046218)	3.60791496
25	tryptophan catabolic process (GO:0006569)	3.60791496
26	coenzyme catabolic process (GO:0009109)	3.58860283
27	DNA double-strand break processing (GO:0000729)	3.57980887
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.57168100
29	base-excision repair, AP site formation (GO:0006285)	3.49935618
30	male meiosis (GO:0007140)	3.48660621
31	branched-chain amino acid catabolic process (GO:0009083)	3.46906872
32	regulation of cellular respiration (GO:0043457)	3.40161447
33	indolalkylamine metabolic process (GO:0006586)	3.39394170
34	purine deoxyribonucleotide metabolic process (GO:0009151)	3.37225007
35	amino acid salvage (GO:0043102)	3.36146951
36	L-methionine salvage (GO:0071267)	3.36146951
37	L-methionine biosynthetic process (GO:0071265)	3.36146951
38	fucose catabolic process (GO:0019317)	3.26140595
39	L-fucose metabolic process (GO:0042354)	3.26140595
40	L-fucose catabolic process (GO:0042355)	3.26140595
41	regulation of centriole replication (GO:0046599)	3.25831406
42	protein localization to cilium (GO:0061512)	3.24406020
43	epithelial cilium movement (GO:0003351)	3.21533666
44	positive regulation of protein homodimerization activity (GO:0090073)	3.21324470
45	intracellular protein transmembrane import (GO:0044743)	3.16579139
46	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.14171484
47	positive regulation of catecholamine secretion (GO:0033605)	3.12655326
48	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.12176912
49	protein complex biogenesis (GO:0070271)	3.08403401
50	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.06312381
51	cellular response to ATP (GO:0071318)	3.04632166
52	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.03538110
53	intraciliary transport (GO:0042073)	3.02460555
54	nucleoside transport (GO:0015858)	2.99522540
55	ribosome assembly (GO:0042255)	2.99504059
56	regulation of autophagic vacuole assembly (GO:2000785)	2.98963268
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.95426467
58	organic cation transport (GO:0015695)	2.91511679
59	peptidyl-histidine modification (GO:0018202)	2.91152587
60	dopamine transport (GO:0015872)	2.83000022
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82982454
62	protein refolding (GO:0042026)	2.78539872
63	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.77987745
64	rRNA catabolic process (GO:0016075)	2.77810327
65	respiratory chain complex IV assembly (GO:0008535)	2.76157496
66	aspartate family amino acid catabolic process (GO:0009068)	2.73671159
67	deoxyribonucleotide biosynthetic process (GO:0009263)	2.72531200
68	branched-chain amino acid metabolic process (GO:0009081)	2.70548608
69	nephron epithelium morphogenesis (GO:0072088)	2.70291885
70	nephron tubule morphogenesis (GO:0072078)	2.70291885
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70156283
72	chaperone-mediated protein transport (GO:0072321)	2.68095640
73	cellular ketone body metabolic process (GO:0046950)	2.67030537
74	prenylation (GO:0097354)	2.65030891
75	protein prenylation (GO:0018342)	2.65030891
76	cytochrome complex assembly (GO:0017004)	2.64406508
77	nucleotide transmembrane transport (GO:1901679)	2.61025669
78	cilium morphogenesis (GO:0060271)	2.60999249
79	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.59539284
80	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.59298490
81	multicellular organism reproduction (GO:0032504)	2.57231471
82	axoneme assembly (GO:0035082)	2.56234243
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.54736059
84	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.54276466
85	ubiquinone biosynthetic process (GO:0006744)	2.52905167
86	nucleoside salvage (GO:0043174)	2.52292396
87	protein import into peroxisome matrix (GO:0016558)	2.51434240
88	xenobiotic catabolic process (GO:0042178)	2.51405035
89	regulation of sulfur metabolic process (GO:0042762)	2.49085883
90	male meiosis I (GO:0007141)	2.49013730
91	behavioral response to ethanol (GO:0048149)	2.47956320
92	kynurenine metabolic process (GO:0070189)	2.47389925
93	negative regulation of telomere maintenance (GO:0032205)	2.47207822
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.45434223
95	cilium movement (GO:0003341)	2.45422493
96	sperm-egg recognition (GO:0035036)	2.44566409
97	nucleoside diphosphate biosynthetic process (GO:0009133)	2.43073720
98	estrogen biosynthetic process (GO:0006703)	2.42883373
99	indole-containing compound metabolic process (GO:0042430)	2.42855404
100	sphingosine metabolic process (GO:0006670)	2.40918769

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.20235782
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.73682010
3	VDR_22108803_ChIP-Seq_LS180_Human	3.72927027
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.47167299
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.29707756
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11895110
7	FUS_26573619_Chip-Seq_HEK293_Human	2.38886468
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17501932
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16061664
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.13013579
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.06861162
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.02127567
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00454277
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.98025151
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96644278
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89991017
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86752643
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83911002
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.75666071
20	P300_19829295_ChIP-Seq_ESCs_Human	1.75619790
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.75464668
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.75464668
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74309788
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73017880
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.68422066
26	EWS_26573619_Chip-Seq_HEK293_Human	1.66127726
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.63493535
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63353391
29	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.61652380
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.58979112
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.53411781
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.53335079
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52601101
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52231435
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51351069
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46040346
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.43264741
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.43086608
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.37802693
40	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.37345547
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37043103
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36509961
43	CDX2_22108803_ChIP-Seq_LS180_Human	1.34872311
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31034556
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29892699
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27513302
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27227291
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.27061222
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.27024700
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26588153
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26453393
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26096600
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25611957
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25516864
55	STAT3_23295773_ChIP-Seq_U87_Human	1.23168207
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23057210
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23057210
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22955084
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21558953
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21558953
61	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20723207
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19280718
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17754359
64	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17324489
65	AR_20517297_ChIP-Seq_VCAP_Human	1.14763035
66	GATA3_26560356_Chip-Seq_TH2_Human	1.14527503
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14503583
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14503583
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14116100
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13055281
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.12048378
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.11450165
73	MYC_18940864_ChIP-ChIP_HL60_Human	1.11327924
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10586173
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10367088
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09059839
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08419683
78	TP53_16413492_ChIP-PET_HCT116_Human	1.08400028
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07483223
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07368005
81	NCOR_22424771_ChIP-Seq_293T_Human	1.06530027
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06412900
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06058630
84	ERA_21632823_ChIP-Seq_H3396_Human	1.03167865
85	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02328616
86	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01448820
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99392323
88	AR_25329375_ChIP-Seq_VCAP_Human	0.98129667
89	TCF4_23295773_ChIP-Seq_U87_Human	0.97422070
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97270867
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96484298
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96344019
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95976306
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94683914
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94356060
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.90854148
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90746990
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90391065
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89896433
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89805903

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	8.66934535
2	MP0008877_abnormal_DNA_methylation	3.37504806
3	MP0003787_abnormal_imprinting	2.92713962
4	MP0002160_abnormal_reproductive_system	2.78114602
5	MP0002138_abnormal_hepatobiliary_system	2.69994365
6	MP0003172_abnormal_lysosome_physiology	2.66751122
7	MP0001764_abnormal_homeostasis	2.42676250
8	MP0002837_dystrophic_cardiac_calcinosis	2.41551347
9	MP0006072_abnormal_retinal_apoptosis	2.26238014
10	MP0008875_abnormal_xenobiotic_pharmacok	2.25648251
11	MP0003195_calcinosis	2.13320869
12	MP0005646_abnormal_pituitary_gland	2.06562594
13	MP0005410_abnormal_fertilization	2.05746816
14	MP0005075_abnormal_melanosome_morpholog	1.91258894
15	MP0009697_abnormal_copulation	1.86432336
16	MP0002254_reproductive_system_inflammat	1.84403656
17	MP0001968_abnormal_touch/_nociception	1.82361554
18	MP0005389_reproductive_system_phenotype	1.82213004
19	MP0000749_muscle_degeneration	1.81417746
20	MP0001661_extended_life_span	1.78766365
21	MP0005551_abnormal_eye_electrophysiolog	1.73337166
22	MP0004484_altered_response_of	1.71498076
23	MP0005174_abnormal_tail_pigmentation	1.69003394
24	MP0004215_abnormal_myocardial_fiber	1.66701913
25	MP0002638_abnormal_pupillary_reflex	1.65857587
26	MP0002139_abnormal_hepatobiliary_system	1.65339498
27	MP0005360_urolithiasis	1.60346118
28	MP0008775_abnormal_heart_ventricle	1.59307627
29	MP0005248_abnormal_Harderian_gland	1.56023846
30	MP0005379_endocrine/exocrine_gland_phen	1.55623519
31	MP0008004_abnormal_stomach_pH	1.49902434
32	MP0002163_abnormal_gland_morphology	1.48361838
33	MP0000015_abnormal_ear_pigmentation	1.44269320
34	MP0003718_maternal_effect	1.39297374
35	MP0000383_abnormal_hair_follicle	1.38237202
36	MP0006036_abnormal_mitochondrial_physio	1.38107288
37	MP0000427_abnormal_hair_cycle	1.35326722
38	MP0001984_abnormal_olfaction	1.33091608
39	MP0008058_abnormal_DNA_repair	1.32821928
40	MP0005253_abnormal_eye_physiology	1.32016471
41	MP0005084_abnormal_gallbladder_morpholo	1.23019988
42	MP0010678_abnormal_skin_adnexa	1.21910251
43	MP0002277_abnormal_respiratory_mucosa	1.12778881
44	MP0000516_abnormal_urinary_system	1.12117286
45	MP0005367_renal/urinary_system_phenotyp	1.12117286
46	MP0002102_abnormal_ear_morphology	1.11759839
47	MP0000569_abnormal_digit_pigmentation	1.08773380
48	MP0004147_increased_porphyrin_level	1.07343917
49	MP0003698_abnormal_male_reproductive	1.06522351
50	MP0001929_abnormal_gametogenesis	1.06502607
51	MP0009780_abnormal_chondrocyte_physiolo	1.04548935
52	MP0005365_abnormal_bile_salt	1.03711861
53	MP0003191_abnormal_cellular_cholesterol	1.02633269
54	MP0001986_abnormal_taste_sensitivity	1.02269464
55	MP0005377_hearing/vestibular/ear_phenot	1.01143146
56	MP0003878_abnormal_ear_physiology	1.01143146
57	MP0005332_abnormal_amino_acid	0.99946601
58	MP0000372_irregular_coat_pigmentation	0.96769345
59	MP0005220_abnormal_exocrine_pancreas	0.96261468
60	MP0008872_abnormal_physiological_respon	0.94396634
61	MP0006054_spinal_hemorrhage	0.94157341
62	MP0004142_abnormal_muscle_tone	0.93775553
63	MP0002693_abnormal_pancreas_physiology	0.93614698
64	MP0001145_abnormal_male_reproductive	0.92534292
65	MP0002210_abnormal_sex_determination	0.92078835
66	MP0002736_abnormal_nociception_after	0.88809178
67	MP0003315_abnormal_perineum_morphology	0.84940904
68	MP0000653_abnormal_sex_gland	0.82379390
69	MP0003646_muscle_fatigue	0.81939841
70	MP0002095_abnormal_skin_pigmentation	0.81248583
71	MP0010386_abnormal_urinary_bladder	0.79415501
72	MP0002269_muscular_atrophy	0.77485739
73	MP0001905_abnormal_dopamine_level	0.75490670
74	MP0004084_abnormal_cardiac_muscle	0.74334206
75	MP0004085_abnormal_heartbeat	0.74238770
76	MP0003936_abnormal_reproductive_system	0.74143238
77	MP0001835_abnormal_antigen_presentation	0.73328090
78	MP0006138_congestive_heart_failure	0.73113477
79	MP0000230_abnormal_systemic_arterial	0.73006101
80	MP0004043_abnormal_pH_regulation	0.71960332
81	MP0005376_homeostasis/metabolism_phenot	0.70806474
82	MP0002229_neurodegeneration	0.68970298
83	MP0001756_abnormal_urination	0.68557332
84	MP0010094_abnormal_chromosome_stability	0.68148535
85	MP0009046_muscle_twitch	0.68076450
86	MP0004381_abnormal_hair_follicle	0.66756641
87	MP0001486_abnormal_startle_reflex	0.66207725
88	MP0000647_abnormal_sebaceous_gland	0.66151722
89	MP0006276_abnormal_autonomic_nervous	0.65404525
90	MP0001529_abnormal_vocalization	0.65372895
91	MP0002733_abnormal_thermal_nociception	0.64636403
92	MP0005636_abnormal_mineral_homeostasis	0.64160468
93	MP0005319_abnormal_enzyme/_coenzyme	0.62419301
94	MP0002127_abnormal_cardiovascular_syste	0.61347099
95	MP0001919_abnormal_reproductive_system	0.60924203
96	MP0008995_early_reproductive_senescence	0.60408408
97	MP0003868_abnormal_feces_composition	0.60317353
98	MP0005266_abnormal_metabolism	0.60196931
99	MP0003786_premature_aging	0.58749310
100	MP0003121_genomic_imprinting	0.57307252

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	4.90117736
2	Type II lissencephaly (HP:0007260)	4.61726289
3	Abnormality of methionine metabolism (HP:0010901)	3.45850122
4	Abnormal pancreas size (HP:0012094)	3.42987057
5	Molar tooth sign on MRI (HP:0002419)	3.35152073
6	Abnormality of midbrain morphology (HP:0002418)	3.35152073
7	Pancreatic cysts (HP:0001737)	3.30340348
8	Pancreatic fibrosis (HP:0100732)	3.25319910
9	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.21241639
10	Hypoplasia of the uterus (HP:0000013)	3.06582202
11	Ketosis (HP:0001946)	3.03932293
12	True hermaphroditism (HP:0010459)	2.91985944
13	Hypomagnesemia (HP:0002917)	2.86441077
14	Ketoacidosis (HP:0001993)	2.85887210
15	Nephronophthisis (HP:0000090)	2.82546014
16	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.75444634
17	Lipid accumulation in hepatocytes (HP:0006561)	2.75148830
18	Chronic hepatic failure (HP:0100626)	2.72719705
19	Short tibia (HP:0005736)	2.63145104
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.62575549
21	Congenital stationary night blindness (HP:0007642)	2.52240310
22	Hypothermia (HP:0002045)	2.48624102
23	Hyperglycemia (HP:0003074)	2.46641002
24	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45995457
25	Chronic diarrhea (HP:0002028)	2.44960205
26	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.44738393
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.44738393
28	Abnormal protein glycosylation (HP:0012346)	2.44738393
29	Abnormal glycosylation (HP:0012345)	2.44738393
30	Calf muscle hypertrophy (HP:0008981)	2.43395427
31	Abnormal respiratory epithelium morphology (HP:0012253)	2.42528180
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42528180
33	Acute hepatic failure (HP:0006554)	2.42419482
34	Recurrent corneal erosions (HP:0000495)	2.36645746
35	Acute necrotizing encephalopathy (HP:0006965)	2.33926273
36	Retinal atrophy (HP:0001105)	2.32546674
37	Renal cortical cysts (HP:0000803)	2.31145082
38	Abnormality of the renal cortex (HP:0011035)	2.31141521
39	Retinal dysplasia (HP:0007973)	2.30828826
40	Progressive macrocephaly (HP:0004481)	2.28426357
41	Poor speech (HP:0002465)	2.27759674
42	Diastasis recti (HP:0001540)	2.27185739
43	Abnormality of the renal medulla (HP:0100957)	2.26774681
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26555682
45	Spontaneous abortion (HP:0005268)	2.23912180
46	Rimmed vacuoles (HP:0003805)	2.22731914
47	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.22521540
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21332415
49	Absent/shortened dynein arms (HP:0200106)	2.21332415
50	Cystic liver disease (HP:0006706)	2.20096553
51	Gaze-evoked nystagmus (HP:0000640)	2.14199806
52	Increased CSF lactate (HP:0002490)	2.14137185
53	Abnormal biliary tract physiology (HP:0012439)	2.13088518
54	Bile duct proliferation (HP:0001408)	2.13088518
55	Occipital encephalocele (HP:0002085)	2.12612335
56	Abolished electroretinogram (ERG) (HP:0000550)	2.11471658
57	Muscle hypertrophy of the lower extremities (HP:0008968)	2.07818687
58	Methylmalonic acidemia (HP:0002912)	2.07469697
59	Hypoplasia of the pons (HP:0012110)	2.07353255
60	Neoplasm of the adrenal cortex (HP:0100641)	2.04435264
61	Abnormal ciliary motility (HP:0012262)	2.04106312
62	Abnormality of the pons (HP:0007361)	2.03927382
63	Mitochondrial inheritance (HP:0001427)	2.02318445
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.00115315
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.00115315
66	Methylmalonic aciduria (HP:0012120)	1.98562839
67	Carpal bone hypoplasia (HP:0001498)	1.97979680
68	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97167561
69	Acute encephalopathy (HP:0006846)	1.96186827
70	Abnormal drinking behavior (HP:0030082)	1.95774450
71	Polydipsia (HP:0001959)	1.95774450
72	Furrowed tongue (HP:0000221)	1.95668615
73	Unsteady gait (HP:0002317)	1.94642604
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.94612089
75	Reduced antithrombin III activity (HP:0001976)	1.91810112
76	3-Methylglutaconic aciduria (HP:0003535)	1.90145974
77	Mesangial abnormality (HP:0001966)	1.90026608
78	Attenuation of retinal blood vessels (HP:0007843)	1.89796612
79	Increased hepatocellular lipid droplets (HP:0006565)	1.87910800
80	Lissencephaly (HP:0001339)	1.87209583
81	Median cleft lip (HP:0000161)	1.85625451
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83751668
83	Congenital, generalized hypertrichosis (HP:0004540)	1.83747154
84	Infertility (HP:0000789)	1.83277356
85	Clumsiness (HP:0002312)	1.81720351
86	Male pseudohermaphroditism (HP:0000037)	1.79851161
87	Lethargy (HP:0001254)	1.79347949
88	Adrenal hypoplasia (HP:0000835)	1.78743397
89	Abnormality of vitamin B metabolism (HP:0004340)	1.76832594
90	Hyperglycinemia (HP:0002154)	1.76374212
91	Sensory axonal neuropathy (HP:0003390)	1.76122653
92	Absent thumb (HP:0009777)	1.75083385
93	Abnormality of magnesium homeostasis (HP:0004921)	1.74305773
94	Facial hemangioma (HP:0000329)	1.74051642
95	Glycosuria (HP:0003076)	1.72157141
96	Abnormality of urine glucose concentration (HP:0011016)	1.72157141
97	Cerebral hemorrhage (HP:0001342)	1.72115464
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.70279661
99	Abnormality of glycine metabolism (HP:0010895)	1.67657623
100	Abnormality of serine family amino acid metabolism (HP:0010894)	1.67657623

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.98923136
2	EIF2AK3	4.71444138
3	MAP3K13	4.60919796
4	PINK1	4.30523147
5	FRK	4.20223487
6	MST4	2.97376116
7	LATS1	2.74635662
8	BCKDK	2.57013134
9	NUAK1	2.17001752
10	STK38L	2.11597903
11	EIF2AK1	2.05078304
12	ZAK	1.86548938
13	PLK4	1.58539865
14	MARK3	1.55317923
15	MAPKAPK5	1.49266134
16	FGFR2	1.44468487
17	OXSR1	1.44357881
18	ACVR1B	1.43726923
19	CSNK1G3	1.41425024
20	MET	1.40191948
21	BMPR1B	1.40087957
22	OBSCN	1.39639418
23	WNK3	1.36597072
24	GRK1	1.34445430
25	MAP3K9	1.34044161
26	WNK4	1.33658560
27	MYLK	1.25588204
28	ADRBK2	1.24567579
29	CSNK1A1L	1.21949077
30	MAP3K14	1.20069977
31	CSNK1G1	1.19219991
32	TNIK	1.16333436
33	CSNK1G2	1.12484027
34	TLK1	1.07386732
35	TXK	1.04492023
36	CDK3	1.02975706
37	TSSK6	1.01770408
38	STK3	0.97711910
39	TGFBR1	0.96648106
40	CDK19	0.95165155
41	TAOK3	0.94332835
42	STK39	0.93878948
43	BRSK2	0.89498329
44	PLK2	0.82418903
45	NEK2	0.81207859
46	TRPM7	0.80427314
47	CAMKK2	0.74235518
48	PNCK	0.74159638
49	PRKCQ	0.73228100
50	TIE1	0.73196282
51	NLK	0.72582416
52	IKBKB	0.68996951
53	PAK3	0.67441277
54	PTK2B	0.66703160
55	ITK	0.65525098
56	FLT3	0.64633078
57	FES	0.63941002
58	PBK	0.56407255
59	PLK3	0.55193463
60	MAPK13	0.54885996
61	MAP2K7	0.54557681
62	ARAF	0.51080422
63	GRK6	0.49097075
64	BTK	0.44368016
65	ADRBK1	0.42945601
66	PRKCE	0.42310029
67	FGR	0.42253071
68	DAPK2	0.42189272
69	PHKG1	0.41631484
70	PHKG2	0.41631484
71	ERBB3	0.41384850
72	WEE1	0.39568736
73	IGF1R	0.37451221
74	EIF2AK2	0.37416946
75	ATM	0.37409549
76	PLK1	0.36259902
77	TEC	0.34587989
78	TAF1	0.32744838
79	CSF1R	0.30925075
80	MKNK1	0.30857599
81	NEK1	0.30545906
82	MAP3K7	0.27637747
83	VRK1	0.27232542
84	MAP3K1	0.27148588
85	EGFR	0.27139733
86	MAP3K12	0.23541590
87	TNK2	0.23432275
88	ROCK1	0.22046275
89	ABL2	0.21880297
90	MOS	0.21609148
91	CSNK1D	0.20565250
92	STK24	0.20431836
93	PASK	0.19467726
94	SYK	0.18618678
95	LYN	0.18071939
96	CSNK1A1	0.16440546
97	KIT	0.16317698
98	NTRK2	0.15177423
99	RPS6KA5	0.15086736
100	NME2	0.13949428

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.94413919
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46843353
3	Propanoate metabolism_Homo sapiens_hsa00640	2.44677881
4	Asthma_Homo sapiens_hsa05310	2.38666814
5	Caffeine metabolism_Homo sapiens_hsa00232	2.37918959
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.37724353
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.21921447
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18812882
9	Butanoate metabolism_Homo sapiens_hsa00650	2.16842980
10	Homologous recombination_Homo sapiens_hsa03440	2.11394741
11	Protein export_Homo sapiens_hsa03060	1.96387510
12	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.92291987
13	Basal transcription factors_Homo sapiens_hsa03022	1.92057061
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90728543
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.74276643
16	Olfactory transduction_Homo sapiens_hsa04740	1.74177602
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67603925
18	Regulation of autophagy_Homo sapiens_hsa04140	1.60444087
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.60335065
20	RNA degradation_Homo sapiens_hsa03018	1.55467209
21	One carbon pool by folate_Homo sapiens_hsa00670	1.51418025
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50376603
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.47780836
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.47286583
25	Purine metabolism_Homo sapiens_hsa00230	1.44558361
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.42009266
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41533658
28	Other glycan degradation_Homo sapiens_hsa00511	1.41408846
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41082929
30	Proteasome_Homo sapiens_hsa03050	1.41076656
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39631427
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35327189
33	Peroxisome_Homo sapiens_hsa04146	1.34972135
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.33157759
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.32058633
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.31119131
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.29111766
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.27483284
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23068235
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.21849123
41	Salivary secretion_Homo sapiens_hsa04970	1.19111129
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18617854
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14647153
44	Parkinsons disease_Homo sapiens_hsa05012	1.13972013
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13053752
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12912867
47	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.10420244
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09843455
49	Allograft rejection_Homo sapiens_hsa05330	1.09445319
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08182890
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06629058
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.05465454
53	Graft-versus-host disease_Homo sapiens_hsa05332	1.05240481
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03457177
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01038620
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95893023
57	Fatty acid degradation_Homo sapiens_hsa00071	0.89611584
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.86837583
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86580341
60	Retinol metabolism_Homo sapiens_hsa00830	0.85473561
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82993661
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82179507
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78464749
64	Mineral absorption_Homo sapiens_hsa04978	0.75924049
65	Alzheimers disease_Homo sapiens_hsa05010	0.75641961
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73547312
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70018389
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68896801
69	RNA polymerase_Homo sapiens_hsa03020	0.68847345
70	Taste transduction_Homo sapiens_hsa04742	0.67766465
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66014644
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63356660
73	Lysine degradation_Homo sapiens_hsa00310	0.62887380
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61548251
75	Metabolic pathways_Homo sapiens_hsa01100	0.61436737
76	Spliceosome_Homo sapiens_hsa03040	0.58688609
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.58412864
78	RNA transport_Homo sapiens_hsa03013	0.57617696
79	Sulfur metabolism_Homo sapiens_hsa00920	0.57102151
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.56574834
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55841827
82	Circadian rhythm_Homo sapiens_hsa04710	0.55096741
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53557673
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53536343
85	Huntingtons disease_Homo sapiens_hsa05016	0.52981956
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.51842560
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50686553
88	Herpes simplex infection_Homo sapiens_hsa05168	0.49371209
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.47898022
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46931295
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45223694
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43599273
93	Fatty acid elongation_Homo sapiens_hsa00062	0.41622008
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40422912
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40117660
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.39608616
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37472293
98	Circadian entrainment_Homo sapiens_hsa04713	0.37436200
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36187333
100	Renin secretion_Homo sapiens_hsa04924	0.34887202

MRPL35P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »