MRPL37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.37422044
2formation of translation preinitiation complex (GO:0001731)4.46972485
3proteasome assembly (GO:0043248)4.26702646
4establishment of integrated proviral latency (GO:0075713)4.20525438
5nucleobase biosynthetic process (GO:0046112)4.13320931
6DNA strand elongation involved in DNA replication (GO:0006271)4.11958598
7purine nucleobase biosynthetic process (GO:0009113)4.09060646
8folic acid metabolic process (GO:0046655)4.05424575
9oxidative phosphorylation (GO:0006119)4.03155301
10maturation of SSU-rRNA (GO:0030490)3.98326982
11telomere maintenance via semi-conservative replication (GO:0032201)3.90472555
12regulation of translational fidelity (GO:0006450)3.88673009
13nucleobase-containing small molecule interconversion (GO:0015949)3.88604454
14mitotic chromosome condensation (GO:0007076)3.87793015
15DNA strand elongation (GO:0022616)3.84923717
16mitotic sister chromatid segregation (GO:0000070)3.82650287
17tricarboxylic acid cycle (GO:0006099)3.81186597
18DNA replication initiation (GO:0006270)3.77196597
19protein maturation by protein folding (GO:0022417)3.71733582
20proline biosynthetic process (GO:0006561)3.69534258
21ribosome biogenesis (GO:0042254)3.61171916
22IMP biosynthetic process (GO:0006188)3.59929310
23folic acid-containing compound biosynthetic process (GO:0009396)3.58752083
24ribosome assembly (GO:0042255)3.58166665
25nuclear pore complex assembly (GO:0051292)3.55952043
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53425553
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52228916
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44843931
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44697701
30DNA unwinding involved in DNA replication (GO:0006268)3.44435406
31telomere maintenance via recombination (GO:0000722)3.41608781
32ribosomal small subunit assembly (GO:0000028)3.41167995
33sister chromatid segregation (GO:0000819)3.40368504
34glycine metabolic process (GO:0006544)3.39294600
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39118376
36DNA replication checkpoint (GO:0000076)3.38260742
37ribosomal large subunit biogenesis (GO:0042273)3.36249494
38ribonucleoprotein complex biogenesis (GO:0022613)3.32365743
39establishment of viral latency (GO:0019043)3.30450428
40spliceosomal snRNP assembly (GO:0000387)3.30182358
41mitotic metaphase plate congression (GO:0007080)3.29065163
42serine family amino acid biosynthetic process (GO:0009070)3.28923153
43mitotic nuclear envelope disassembly (GO:0007077)3.27041459
44IMP metabolic process (GO:0046040)3.23089398
45mitotic recombination (GO:0006312)3.22596678
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22183467
47nuclear pore organization (GO:0006999)3.21818350
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21156380
49viral transcription (GO:0019083)3.17582705
50negative regulation of ligase activity (GO:0051352)3.16465867
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16465867
52translational termination (GO:0006415)3.15971551
53peptidyl-arginine omega-N-methylation (GO:0035247)3.14789350
54translational elongation (GO:0006414)3.14739061
55L-serine metabolic process (GO:0006563)3.14045994
56lysine catabolic process (GO:0006554)3.13860614
57lysine metabolic process (GO:0006553)3.13860614
58translational initiation (GO:0006413)3.13757982
59NADH metabolic process (GO:0006734)3.12297666
60regulation of cellular amino acid metabolic process (GO:0006521)3.12036287
61protein localization to kinetochore (GO:0034501)3.11657288
62ATP synthesis coupled proton transport (GO:0015986)3.11018166
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11018166
64protein targeting to mitochondrion (GO:0006626)3.09214158
65pseudouridine synthesis (GO:0001522)3.08229684
66amino acid salvage (GO:0043102)3.07764145
67L-methionine salvage (GO:0071267)3.07764145
68L-methionine biosynthetic process (GO:0071265)3.07764145
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06812270
70deoxyribonucleotide biosynthetic process (GO:0009263)3.06804540
71transcription from mitochondrial promoter (GO:0006390)3.06097222
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05157810
73DNA replication-dependent nucleosome assembly (GO:0006335)3.04637577
74DNA replication-dependent nucleosome organization (GO:0034723)3.04637577
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03631666
76rRNA modification (GO:0000154)2.99714901
77COPI coating of Golgi vesicle (GO:0048205)2.99643210
78Golgi transport vesicle coating (GO:0048200)2.99643210
79telomere maintenance via telomere lengthening (GO:0010833)2.98999849
80nuclear envelope disassembly (GO:0051081)2.98012864
81membrane disassembly (GO:0030397)2.98012864
82viral mRNA export from host cell nucleus (GO:0046784)2.97995805
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97988257
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97988257
85pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97244689
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96696714
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.96696714
88chromatin remodeling at centromere (GO:0031055)2.96193474
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95992484
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95992484
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95992484
92rRNA processing (GO:0006364)2.94750153
93CENP-A containing nucleosome assembly (GO:0034080)2.94355063
94transcription-coupled nucleotide-excision repair (GO:0006283)2.93494127
95positive regulation of ligase activity (GO:0051351)2.93295997
96regulation of translational termination (GO:0006449)2.92631642
97pteridine-containing compound biosynthetic process (GO:0042559)2.92607271
98protein complex localization (GO:0031503)2.92576366
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.91034004
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.90353436
101negative regulation of mRNA processing (GO:0050686)2.89864544
102base-excision repair (GO:0006284)2.88191533
103* translation (GO:0006412)2.83988331
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83601104
105mitochondrial RNA metabolic process (GO:0000959)2.83438863
106aspartate family amino acid biosynthetic process (GO:0009067)2.82314762
107rRNA metabolic process (GO:0016072)2.82268794
108metaphase plate congression (GO:0051310)2.80968785
109tRNA aminoacylation for protein translation (GO:0006418)2.80101940
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.80016371
111protein deneddylation (GO:0000338)2.78642543
112cullin deneddylation (GO:0010388)2.78615276
113DNA replication-independent nucleosome assembly (GO:0006336)2.78460847
114DNA replication-independent nucleosome organization (GO:0034724)2.78460847
115cell cycle G1/S phase transition (GO:0044843)2.77650180
116G1/S transition of mitotic cell cycle (GO:0000082)2.77650180
117regulation of mitochondrial translation (GO:0070129)2.77602371
118tRNA aminoacylation (GO:0043039)2.77338964
119amino acid activation (GO:0043038)2.77338964
120ribosomal small subunit biogenesis (GO:0042274)2.75774629
121cellular component biogenesis (GO:0044085)2.75363495
122sulfur amino acid biosynthetic process (GO:0000097)2.74634758
123protein localization to chromosome, centromeric region (GO:0071459)2.73765707
124methionine biosynthetic process (GO:0009086)2.71936188
125regulation of ubiquitin-protein transferase activity (GO:0051438)2.71065909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54259272
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.38139994
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.13514592
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20454116
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04014008
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.03920285
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95045609
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.93862029
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.84374280
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80502403
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70188931
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69182751
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.68260941
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66212296
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48806309
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47215197
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37405664
18* XRN2_22483619_ChIP-Seq_HELA_Human2.33603108
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24487721
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22157827
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10349106
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03586423
23VDR_23849224_ChIP-Seq_CD4+_Human2.00511654
24DCP1A_22483619_ChIP-Seq_HELA_Human1.99862132
25AR_21909140_ChIP-Seq_LNCAP_Human1.93367882
26GABP_19822575_ChIP-Seq_HepG2_Human1.90647061
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89289074
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86936707
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.83471115
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82112840
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79882703
32FOXP3_21729870_ChIP-Seq_TREG_Human1.79294240
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75359859
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70850662
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69812301
36CIITA_25753668_ChIP-Seq_RAJI_Human1.69455204
37* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69320692
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68321331
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67416996
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65857722
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63094454
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.62155532
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59148486
44MYC_22102868_ChIP-Seq_BL_Human1.57607835
45* TTF2_22483619_ChIP-Seq_HELA_Human1.55052445
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.52374068
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50691363
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48302582
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46762003
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46326313
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44359063
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42404012
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38974056
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38860917
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.38464092
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37454949
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35885906
58ZNF263_19887448_ChIP-Seq_K562_Human1.35293397
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30933804
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29489368
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29466985
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28415839
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28316357
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27190134
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24278145
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24276750
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21522069
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18310912
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17894350
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16130405
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16128897
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14693063
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.12598214
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11132170
75VDR_21846776_ChIP-Seq_THP-1_Human1.09957131
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09650235
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08336006
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07798136
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06987543
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05993035
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04932848
82* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04163816
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02988315
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02904907
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02756136
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.02462499
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00961966
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00897395
89TFEB_21752829_ChIP-Seq_HELA_Human0.99906404
90ELK1_19687146_ChIP-ChIP_HELA_Human0.99891855
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97139902
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96294564
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95714867
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.94527044
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.92707393
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92280982
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92009521
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91932092
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91792767
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90972649
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90387784
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89087453
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88400590
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87809160
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.87666140
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87660160
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86958475
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86368318
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85465125
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85259967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.71294009
2MP0003806_abnormal_nucleotide_metabolis4.20826991
3MP0004957_abnormal_blastocyst_morpholog3.81461853
4MP0003111_abnormal_nucleus_morphology3.57065195
5MP0010094_abnormal_chromosome_stability3.37942271
6MP0003077_abnormal_cell_cycle3.06131415
7MP0003646_muscle_fatigue2.85350873
8MP0006036_abnormal_mitochondrial_physio2.49652271
9MP0008058_abnormal_DNA_repair2.31277047
10MP0008007_abnormal_cellular_replicative2.23658754
11MP0005360_urolithiasis2.23266047
12MP0004084_abnormal_cardiac_muscle2.19692349
13MP0002877_abnormal_melanocyte_morpholog2.17986477
14MP0009697_abnormal_copulation2.15799066
15MP0002139_abnormal_hepatobiliary_system2.15567130
16MP0005451_abnormal_body_composition2.15333168
17MP0001730_embryonic_growth_arrest2.14945274
18MP0008057_abnormal_DNA_replication2.08236007
19MP0008932_abnormal_embryonic_tissue2.01566476
20MP0006035_abnormal_mitochondrial_morpho1.96776345
21MP0002269_muscular_atrophy1.83035417
22MP0002396_abnormal_hematopoietic_system1.82885981
23MP0005365_abnormal_bile_salt1.82485457
24MP0000749_muscle_degeneration1.82055028
25MP0010030_abnormal_orbit_morphology1.79189141
26MP0005330_cardiomyopathy1.78749161
27MP0003186_abnormal_redox_activity1.76967806
28MP0001661_extended_life_span1.76177538
29MP0005085_abnormal_gallbladder_physiolo1.75977290
30MP0000750_abnormal_muscle_regeneration1.74840603
31MP0004215_abnormal_myocardial_fiber1.70680212
32MP0009840_abnormal_foam_cell1.68969255
33MP0008260_abnormal_autophagy1.67191127
34MP0000350_abnormal_cell_proliferation1.60258984
35MP0003786_premature_aging1.59325423
36MP0003221_abnormal_cardiomyocyte_apopto1.59076511
37MP0010352_gastrointestinal_tract_polyps1.58746718
38MP0003656_abnormal_erythrocyte_physiolo1.51647044
39MP0005501_abnormal_skin_physiology1.45110197
40MP0003984_embryonic_growth_retardation1.44098016
41MP0005332_abnormal_amino_acid1.43774189
42MP0001672_abnormal_embryogenesis/_devel1.43280018
43MP0005380_embryogenesis_phenotype1.43280018
44MP0004185_abnormal_adipocyte_glucose1.43018455
45MP0000751_myopathy1.42879751
46MP0001697_abnormal_embryo_size1.42724112
47MP0002837_dystrophic_cardiac_calcinosis1.42601046
48MP0002080_prenatal_lethality1.40339558
49MP0002088_abnormal_embryonic_growth/wei1.40007078
50MP0004087_abnormal_muscle_fiber1.36656764
51MP0005083_abnormal_biliary_tract1.35781249
52MP0003567_abnormal_fetal_cardiomyocyte1.35605237
53MP0003315_abnormal_perineum_morphology1.34403279
54MP0004036_abnormal_muscle_relaxation1.34164377
55MP0003941_abnormal_skin_development1.31665282
56MP0003123_paternal_imprinting1.30689978
57MP0005266_abnormal_metabolism1.30333222
58MP0000678_abnormal_parathyroid_gland1.30018254
59MP0000747_muscle_weakness1.24276143
60MP0003718_maternal_effect1.23293767
61MP0000358_abnormal_cell_content/1.22009480
62MP0005319_abnormal_enzyme/_coenzyme1.21828357
63MP0003705_abnormal_hypodermis_morpholog1.21531789
64MP0010630_abnormal_cardiac_muscle1.16393354
65MP0005670_abnormal_white_adipose1.16243011
66MP0000313_abnormal_cell_death1.12490479
67MP0004233_abnormal_muscle_weight1.09691032
68MP0001764_abnormal_homeostasis1.09059435
69MP0002019_abnormal_tumor_incidence1.08161459
70MP0000490_abnormal_crypts_of1.06943031
71MP0001853_heart_inflammation1.06481174
72MP0002796_impaired_skin_barrier1.05662026
73MP0005397_hematopoietic_system_phenotyp1.05129564
74MP0001545_abnormal_hematopoietic_system1.05129564
75MP0005408_hypopigmentation1.03522838
76MP0001544_abnormal_cardiovascular_syste1.01928573
77MP0005385_cardiovascular_system_phenoty1.01928573
78MP0002106_abnormal_muscle_physiology1.00821223
79MP0002085_abnormal_embryonic_tissue1.00230688
80MP0009333_abnormal_splenocyte_physiolog0.99920254
81MP0000537_abnormal_urethra_morphology0.99431528
82MP0005384_cellular_phenotype0.96869450
83MP0002086_abnormal_extraembryonic_tissu0.96856788
84MP0004147_increased_porphyrin_level0.94569778
85MP0008775_abnormal_heart_ventricle0.94176809
86MP0006054_spinal_hemorrhage0.94081871
87MP0001346_abnormal_lacrimal_gland0.93634809
88MP0000609_abnormal_liver_physiology0.92337688
89MP0000759_abnormal_skeletal_muscle0.91964480
90MP0005058_abnormal_lysosome_morphology0.90967767
91MP0000598_abnormal_liver_morphology0.90877202
92MP0000372_irregular_coat_pigmentation0.90002131
93MP0001727_abnormal_embryo_implantation0.89394130
94MP0003763_abnormal_thymus_physiology0.87310059
95MP0001881_abnormal_mammary_gland0.86806246
96MP0008877_abnormal_DNA_methylation0.86096708
97MP0002160_abnormal_reproductive_system0.85003405
98MP0010307_abnormal_tumor_latency0.83792469
99MP0005621_abnormal_cell_physiology0.83650850
100MP0009643_abnormal_urine_homeostasis0.83585319
101MP0002127_abnormal_cardiovascular_syste0.82829843
102MP0002084_abnormal_developmental_patter0.82279717
103MP0001666_abnormal_nutrient_absorption0.80561340
104MP0004808_abnormal_hematopoietic_stem0.79909541
105MP0005623_abnormal_meninges_morphology0.79690331
106MP0008875_abnormal_xenobiotic_pharmacok0.79557023
107MP0010329_abnormal_lipoprotein_level0.79060034
108MP0004197_abnormal_fetal_growth/weight/0.76440290
109MP0003137_abnormal_impulse_conducting0.75717663
110MP0003191_abnormal_cellular_cholesterol0.75456764
111MP0002697_abnormal_eye_size0.74173637
112MP0001849_ear_inflammation0.72894861
113MP0003566_abnormal_cell_adhesion0.72831854
114MP0009672_abnormal_birth_weight0.72621548
115MP0002210_abnormal_sex_determination0.72140584
116MP0002653_abnormal_ependyma_morphology0.71301082
117MP0005666_abnormal_adipose_tissue0.70979223
118MP0001145_abnormal_male_reproductive0.70748344
119MP0005620_abnormal_muscle_contractility0.70314358
120MP0001929_abnormal_gametogenesis0.69548220
121MP0005584_abnormal_enzyme/coenzyme_acti0.69547880
122MP0001293_anophthalmia0.68662402
123MP0005369_muscle_phenotype0.68363419
124MP0002970_abnormal_white_adipose0.67795731
125MP0002722_abnormal_immune_system0.67174149
126MP0000858_altered_metastatic_potential0.66496921
127MP0002111_abnormal_tail_morphology0.66156985
128MP0005376_homeostasis/metabolism_phenot0.65537958
129MP0002060_abnormal_skin_morphology0.65299382
130MP0005076_abnormal_cell_differentiation0.62326227
131MP0004858_abnormal_nervous_system0.61075743
132MP0002234_abnormal_pharynx_morphology0.59490789
133MP0008438_abnormal_cutaneous_collagen0.59309215
134MP0003385_abnormal_body_wall0.58871444
135MP0004272_abnormal_basement_membrane0.58734487
136MP0000653_abnormal_sex_gland0.56301068
137MP0002938_white_spotting0.55509360
138MP0002132_abnormal_respiratory_system0.55096729

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.07212926
2Microvesicular hepatic steatosis (HP:0001414)3.80997901
3Hepatocellular necrosis (HP:0001404)3.76059681
4Cholecystitis (HP:0001082)3.74306753
5Abnormal gallbladder physiology (HP:0012438)3.74306753
6Rhabdomyolysis (HP:0003201)3.58869430
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35058078
8Multiple enchondromatosis (HP:0005701)3.33411443
9Abnormality of alanine metabolism (HP:0010916)3.28975321
10Hyperalaninemia (HP:0003348)3.28975321
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.28975321
12Birth length less than 3rd percentile (HP:0003561)3.26242482
13Abnormal number of erythroid precursors (HP:0012131)3.25394023
14Abnormality of cells of the erythroid lineage (HP:0012130)3.23415064
15Increased CSF lactate (HP:0002490)3.23231838
16Increased serum lactate (HP:0002151)3.23131438
17Increased serum pyruvate (HP:0003542)3.19099952
18Abnormality of glycolysis (HP:0004366)3.19099952
19Myoglobinuria (HP:0002913)3.17330622
20Abnormal mitochondria in muscle tissue (HP:0008316)3.16611031
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16526742
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16526742
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15569100
24Dicarboxylic aciduria (HP:0003215)3.15569100
25Hyperammonemia (HP:0001987)3.15012201
26Oral leukoplakia (HP:0002745)3.14117194
27Progressive muscle weakness (HP:0003323)3.11097755
28Acute encephalopathy (HP:0006846)3.07549764
29Mitochondrial inheritance (HP:0001427)3.07425748
30Acute necrotizing encephalopathy (HP:0006965)3.07240662
31Lactic acidosis (HP:0003128)3.06684079
32Chromsome breakage (HP:0040012)3.04893843
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02816670
34Hyperglycinuria (HP:0003108)3.01901111
35Cerebral edema (HP:0002181)2.95056469
36Increased muscle lipid content (HP:0009058)2.90548362
37Abnormality of fatty-acid metabolism (HP:0004359)2.90530292
38Nausea (HP:0002018)2.86123839
39Abnormality of glycine metabolism (HP:0010895)2.85444707
40Abnormality of serine family amino acid metabolism (HP:0010894)2.85444707
41Hyperglycinemia (HP:0002154)2.79653887
42Breast hypoplasia (HP:0003187)2.78206302
43Increased intramyocellular lipid droplets (HP:0012240)2.71871585
44Selective tooth agenesis (HP:0001592)2.71260520
45Hypoglycemic coma (HP:0001325)2.68688654
46Exercise-induced muscle cramps (HP:0003710)2.67966783
47Lethargy (HP:0001254)2.66461667
48Abnormality of serum amino acid levels (HP:0003112)2.64567275
49Reticulocytopenia (HP:0001896)2.63229559
50Type I transferrin isoform profile (HP:0003642)2.63182519
51Reduced antithrombin III activity (HP:0001976)2.60801581
52Abnormality of the anterior horn cell (HP:0006802)2.59215900
53Degeneration of anterior horn cells (HP:0002398)2.59215900
54CNS demyelination (HP:0007305)2.58837172
55Lipid accumulation in hepatocytes (HP:0006561)2.53629483
56Abnormality of the umbilical cord (HP:0010881)2.52623066
57Carpal bone hypoplasia (HP:0001498)2.49428036
58Exercise intolerance (HP:0003546)2.49195781
59Ketosis (HP:0001946)2.45939666
60Respiratory failure (HP:0002878)2.45214208
61Generalized aminoaciduria (HP:0002909)2.43703853
62Microretrognathia (HP:0000308)2.41982449
63Cerebral hypomyelination (HP:0006808)2.41360809
64Ragged-red muscle fibers (HP:0003200)2.38028157
65Trismus (HP:0000211)2.37442552
66Macrocytic anemia (HP:0001972)2.36439863
67Abnormality of pyrimidine metabolism (HP:0004353)2.34465978
68Rough bone trabeculation (HP:0100670)2.32174398
69Palpitations (HP:0001962)2.29598433
70Emotional lability (HP:0000712)2.29337715
71Proximal tubulopathy (HP:0000114)2.27724813
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25251906
73Testicular atrophy (HP:0000029)2.24968996
74Cholelithiasis (HP:0001081)2.24336780
75Gout (HP:0001997)2.24212500
76Increased hepatocellular lipid droplets (HP:0006565)2.21074951
77Progressive external ophthalmoplegia (HP:0000590)2.20875507
78Hypobetalipoproteinemia (HP:0003563)2.19368129
79Abnormality of the preputium (HP:0100587)2.18703784
80Progressive macrocephaly (HP:0004481)2.15356332
81Megaloblastic anemia (HP:0001889)2.15243145
82Ketoacidosis (HP:0001993)2.14418875
83Abnormal umbilical cord blood vessels (HP:0011403)2.14075680
84Single umbilical artery (HP:0001195)2.14075680
85Abnormality of the fetal cardiovascular system (HP:0010948)2.14075680
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13192241
87Abnormal protein N-linked glycosylation (HP:0012347)2.13192241
88Abnormal protein glycosylation (HP:0012346)2.13192241
89Abnormal glycosylation (HP:0012345)2.13192241
90Myopathic facies (HP:0002058)2.13038054
91Methylmalonic aciduria (HP:0012120)2.10601834
92Ventricular tachycardia (HP:0004756)2.10354485
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04718309
94Premature ovarian failure (HP:0008209)2.04385451
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.04265276
96Pancytopenia (HP:0001876)2.03983872
97Patellar aplasia (HP:0006443)2.03813426
98Colon cancer (HP:0003003)2.02530689
99Abnormalities of placenta or umbilical cord (HP:0001194)2.01515082
100Angiofibromas (HP:0010615)2.01101663
101Adenoma sebaceum (HP:0009720)2.01101663
102Horseshoe kidney (HP:0000085)1.98978078
103Respiratory difficulties (HP:0002880)1.98222923
104Abnormality of reticulocytes (HP:0004312)1.97327268
105Abnormal gallbladder morphology (HP:0012437)1.96760021
106Aplasia/Hypoplasia of the patella (HP:0006498)1.95925140
107Increased nuchal translucency (HP:0010880)1.95171907
108Secondary amenorrhea (HP:0000869)1.93094421
109Neonatal death (HP:0003811)1.92944609
110Abnormality of methionine metabolism (HP:0010901)1.92140531
111Exercise-induced myalgia (HP:0003738)1.90734765
112Metabolic acidosis (HP:0001942)1.90711873
113Reticulocytosis (HP:0001923)1.89239925
114Meckel diverticulum (HP:0002245)1.88924664
115Ependymoma (HP:0002888)1.88804563
116Sudden death (HP:0001699)1.86994642
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.86869151
118Spastic paraparesis (HP:0002313)1.86324339
119Pallor (HP:0000980)1.86019312
120Facial cleft (HP:0002006)1.84340480
121Abnormality of the gallbladder (HP:0005264)1.83381113
122Muscle fiber splitting (HP:0003555)1.82022382
123Areflexia of lower limbs (HP:0002522)1.80877192
124Vomiting (HP:0002013)1.80460000
125Late onset (HP:0003584)1.80161405
126Proximal placement of thumb (HP:0009623)1.79602550
127Truncus arteriosus (HP:0001660)1.79408480
128Myelodysplasia (HP:0002863)1.79183379
129Abnormal trabecular bone morphology (HP:0100671)1.78936281
130Abnormality of sulfur amino acid metabolism (HP:0004339)1.78826610
131Gliosis (HP:0002171)1.77466987
132Achilles tendon contracture (HP:0001771)1.77444080
133Aplastic anemia (HP:0001915)1.77340536
134Sparse eyelashes (HP:0000653)1.77156110
135Difficulty climbing stairs (HP:0003551)1.76698905
136Increased purine levels (HP:0004368)1.76107721
137Hyperuricemia (HP:0002149)1.76107721
138Spastic diplegia (HP:0001264)1.76073167
139Medulloblastoma (HP:0002885)1.75043126
140Lipoatrophy (HP:0100578)1.74468586
141Calcaneovalgus deformity (HP:0001848)1.73125243
142Abnormality of the ileum (HP:0001549)1.71702103
143Breech presentation (HP:0001623)1.70957438
144Squamous cell carcinoma (HP:0002860)1.70682962
145Hypokinesia (HP:0002375)1.70459683
146Nonimmune hydrops fetalis (HP:0001790)1.69451851
147Septate vagina (HP:0001153)1.69042583
148Deviation of the thumb (HP:0009603)1.68697404
149Muscle stiffness (HP:0003552)1.68681296
150Nemaline bodies (HP:0003798)1.67126324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.16215951
2BCKDK3.82187431
3EIF2AK13.77895520
4VRK23.56515957
5NEK13.41224560
6WEE13.36635089
7CDC72.73123986
8NME22.57124052
9SMG12.56607150
10TESK22.45950296
11STK162.37750641
12NEK22.14508184
13TTK2.06154668
14PDK32.00170114
15PDK42.00170114
16TSSK61.91657908
17EIF2AK31.90351415
18ACVR1B1.88873653
19KDR1.85610374
20TRIB31.80955064
21PKN21.74659814
22MAP3K101.71716964
23MAP3K111.67528374
24ERN11.56269630
25PLK11.53225886
26TTN1.45426402
27NME11.41530359
28SRPK11.34346455
29PLK41.30447312
30TESK11.30258442
31RPS6KB21.28120016
32AURKB1.27413405
33MAPKAPK31.24803979
34ARAF1.23774700
35PIM21.21156020
36EPHA21.20950609
37VRK11.18762170
38AURKA1.17618764
39MAP3K81.17111485
40PAK41.16151235
41CDK41.13964464
42SCYL21.13643464
43ICK1.12376813
44BRSK11.12232977
45OBSCN1.09528837
46PDK21.09109578
47ATR1.06868018
48TAF11.02301481
49CCNB10.99274224
50CDK70.97800344
51LRRK20.96922830
52RPS6KA40.96216107
53MAP4K10.94048834
54STK100.92493649
55DAPK10.84697969
56BRSK20.84344438
57TAOK20.84167462
58EEF2K0.83942954
59ILK0.83923476
60DYRK30.83873892
61PINK10.82935053
62TLK10.81278000
63PLK30.77227285
64CHEK20.77015984
65STK40.76583272
66LMTK20.76433788
67PASK0.76098818
68MST1R0.75648477
69MAP2K30.75376406
70TGFBR10.74108187
71CHEK10.74041851
72STK38L0.73173960
73FLT30.73048799
74MST40.70161321
75CLK10.69650893
76ALK0.68849512
77LIMK10.68038961
78CDK190.64083843
79CDK80.63960705
80PRPF4B0.62550278
81MAPK110.60040589
82MAP3K50.59371603
83ATM0.59125072
84CSNK2A20.58427219
85PAK10.57981707
86BRAF0.57340250
87CSNK2A10.56866062
88CSNK1G30.56646020
89PRKCI0.54116835
90IRAK30.53797861
91ZAK0.53268524
92MYLK0.52390427
93CDK11A0.52313629
94LATS20.52289860
95RPS6KA50.51839080
96AKT20.51832216
97RAF10.50093504
98CDK20.49084432
99TRIM280.48987174
100ABL20.47941523
101MAPKAPK50.45842798
102MELK0.44743473
103CDK150.44585111
104CDK140.44108826
105ERBB40.43874298
106CDK180.43415952
107PIM10.42445211
108GRK60.42142360
109TYK20.41398678
110ZAP700.40607601
111MAP2K60.40361255
112PAK20.40310136
113CDK90.38076621
114NEK90.37897420
115MAP3K30.37785381
116MAP2K20.37204094
117PHKG20.36890600
118PHKG10.36890600
119CSNK1A1L0.36177596
120MKNK10.35750755
121PBK0.35364051
122EIF2AK20.34233551
123MTOR0.34056666
124CSNK1G10.33952023
125DAPK30.33757458
126PRKD30.32382181
127BLK0.32350053
128CDK120.31178570
129CDK10.30747569

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.65787412
2Proteasome_Homo sapiens_hsa030503.39392559
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.36423914
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.12077589
5Mismatch repair_Homo sapiens_hsa034302.96998287
6Ribosome_Homo sapiens_hsa030102.76309971
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53548336
8RNA polymerase_Homo sapiens_hsa030202.38878712
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31068375
10Spliceosome_Homo sapiens_hsa030402.26155395
11Carbon metabolism_Homo sapiens_hsa012002.21810210
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21094930
13Base excision repair_Homo sapiens_hsa034102.20358950
14One carbon pool by folate_Homo sapiens_hsa006702.20272269
15RNA transport_Homo sapiens_hsa030132.16070104
16Biosynthesis of amino acids_Homo sapiens_hsa012302.05910601
17Pyrimidine metabolism_Homo sapiens_hsa002402.02594413
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98339515
19Homologous recombination_Homo sapiens_hsa034401.90019315
20Propanoate metabolism_Homo sapiens_hsa006401.88618809
21Nucleotide excision repair_Homo sapiens_hsa034201.86240262
22Parkinsons disease_Homo sapiens_hsa050121.76854875
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.75599803
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65744735
25Fatty acid degradation_Homo sapiens_hsa000711.63917931
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63631854
27Pyruvate metabolism_Homo sapiens_hsa006201.63609908
28Pentose phosphate pathway_Homo sapiens_hsa000301.56314367
29Cell cycle_Homo sapiens_hsa041101.54894212
30Oxidative phosphorylation_Homo sapiens_hsa001901.52529546
31Selenocompound metabolism_Homo sapiens_hsa004501.51870700
32Folate biosynthesis_Homo sapiens_hsa007901.49545461
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.46713690
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38130233
35Huntingtons disease_Homo sapiens_hsa050161.27985003
36Vitamin B6 metabolism_Homo sapiens_hsa007501.25958596
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.24190567
38RNA degradation_Homo sapiens_hsa030181.16032150
39Sulfur relay system_Homo sapiens_hsa041221.14596286
40Fatty acid metabolism_Homo sapiens_hsa012121.10486355
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09079537
42Fructose and mannose metabolism_Homo sapiens_hsa000511.04044009
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02880966
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01216537
45Purine metabolism_Homo sapiens_hsa002301.01166005
46Glutathione metabolism_Homo sapiens_hsa004800.94140901
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93995131
48Fanconi anemia pathway_Homo sapiens_hsa034600.93320207
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87651959
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86705544
51Alzheimers disease_Homo sapiens_hsa050100.86657007
52N-Glycan biosynthesis_Homo sapiens_hsa005100.85503709
53Tryptophan metabolism_Homo sapiens_hsa003800.84216769
54Cardiac muscle contraction_Homo sapiens_hsa042600.83320419
55Non-homologous end-joining_Homo sapiens_hsa034500.81837942
56Peroxisome_Homo sapiens_hsa041460.80969703
57Protein export_Homo sapiens_hsa030600.79169528
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.79043381
59Basal transcription factors_Homo sapiens_hsa030220.78914119
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78559372
61Arginine and proline metabolism_Homo sapiens_hsa003300.77616220
62Arginine biosynthesis_Homo sapiens_hsa002200.77339462
63beta-Alanine metabolism_Homo sapiens_hsa004100.76520271
64Butanoate metabolism_Homo sapiens_hsa006500.74076744
65mRNA surveillance pathway_Homo sapiens_hsa030150.73937685
66p53 signaling pathway_Homo sapiens_hsa041150.72649334
67Steroid biosynthesis_Homo sapiens_hsa001000.68527600
68Epstein-Barr virus infection_Homo sapiens_hsa051690.67676992
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67596984
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61471682
71Metabolic pathways_Homo sapiens_hsa011000.61461610
72Fat digestion and absorption_Homo sapiens_hsa049750.60319082
73Galactose metabolism_Homo sapiens_hsa000520.59676854
74Sulfur metabolism_Homo sapiens_hsa009200.59481988
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57918977
76Phenylalanine metabolism_Homo sapiens_hsa003600.53411411
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51962258
78PPAR signaling pathway_Homo sapiens_hsa033200.51419271
79Caffeine metabolism_Homo sapiens_hsa002320.49288433
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48206636
81Bladder cancer_Homo sapiens_hsa052190.42943437
82Legionellosis_Homo sapiens_hsa051340.39389426
83Starch and sucrose metabolism_Homo sapiens_hsa005000.39343476
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38421536
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38282074
86Fatty acid elongation_Homo sapiens_hsa000620.37138281
87Vibrio cholerae infection_Homo sapiens_hsa051100.36807008
88Oocyte meiosis_Homo sapiens_hsa041140.36741899
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34597783
90Lysine degradation_Homo sapiens_hsa003100.32656810
91Herpes simplex infection_Homo sapiens_hsa051680.29591773
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.29361724
93Chemical carcinogenesis_Homo sapiens_hsa052040.29074452
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28389122
95Thyroid cancer_Homo sapiens_hsa052160.28287041
96Systemic lupus erythematosus_Homo sapiens_hsa053220.27807662
97Tyrosine metabolism_Homo sapiens_hsa003500.26962821
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23587745
99HTLV-I infection_Homo sapiens_hsa051660.23300964
100Shigellosis_Homo sapiens_hsa051310.23261712
101Viral carcinogenesis_Homo sapiens_hsa052030.20800022
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20544193
103Glycerolipid metabolism_Homo sapiens_hsa005610.20272233
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20144741
105Chronic myeloid leukemia_Homo sapiens_hsa052200.17458497
106Vitamin digestion and absorption_Homo sapiens_hsa049770.17153993
107HIF-1 signaling pathway_Homo sapiens_hsa040660.17120266
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14857585
109Regulation of autophagy_Homo sapiens_hsa041400.14242486
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14188412
111Antigen processing and presentation_Homo sapiens_hsa046120.13998483
112Alcoholism_Homo sapiens_hsa050340.12089471
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11012701
114Retinol metabolism_Homo sapiens_hsa008300.10904511
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10277584
116Apoptosis_Homo sapiens_hsa042100.08890878
117Pancreatic cancer_Homo sapiens_hsa052120.07160319
118Small cell lung cancer_Homo sapiens_hsa052220.06986608
119Other glycan degradation_Homo sapiens_hsa005110.04841988
120Prion diseases_Homo sapiens_hsa050200.04298589

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