MRPL37P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.24528994
2regulation of isotype switching to IgG isotypes (GO:0048302)5.58412499
3negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.56504889
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.28388854
5negative regulation of cAMP-mediated signaling (GO:0043951)5.09859037
6regulation of glucokinase activity (GO:0033131)4.99976772
7regulation of hexokinase activity (GO:1903299)4.99976772
8negative thymic T cell selection (GO:0045060)4.84701404
9negative T cell selection (GO:0043383)4.82839935
10intestinal epithelial cell development (GO:0060576)4.64030904
11regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.58281786
12positive regulation of DNA recombination (GO:0045911)4.37541377
13negative regulation of T cell receptor signaling pathway (GO:0050860)4.30323716
14negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.25141217
15negative regulation of T-helper cell differentiation (GO:0045623)4.25141217
16positive regulation of isotype switching (GO:0045830)4.17254388
17response to interleukin-15 (GO:0070672)4.13488082
18regulation of T cell receptor signaling pathway (GO:0050856)4.10429980
19positive regulation of B cell differentiation (GO:0045579)4.08404566
20sulfur amino acid catabolic process (GO:0000098)4.08132520
21positive T cell selection (GO:0043368)4.04032141
22regulation of alkaline phosphatase activity (GO:0010692)4.03012388
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.97036438
24negative regulation of bone resorption (GO:0045779)3.89160108
25negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.88696801
26positive regulation of developmental pigmentation (GO:0048087)3.79436427
27antigen receptor-mediated signaling pathway (GO:0050851)3.77158859
28positive regulation of mRNA catabolic process (GO:0061014)3.74363107
29positive regulation of granulocyte differentiation (GO:0030854)3.70977639
30fibroblast migration (GO:0010761)3.61576239
31T cell receptor signaling pathway (GO:0050852)3.59443037
32positive regulation of alpha-beta T cell proliferation (GO:0046641)3.49217344
33protein K11-linked deubiquitination (GO:0035871)3.48155057
34cellular response to interleukin-15 (GO:0071350)3.48147350
35negative regulation of B cell proliferation (GO:0030889)3.43590780
36T cell selection (GO:0045058)3.41904054
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41725360
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.35509794
39thymic T cell selection (GO:0045061)3.34415190
40muscle organ morphogenesis (GO:0048644)3.34284487
41interferon-gamma production (GO:0032609)3.33080298
42positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.30596482
43response to type I interferon (GO:0034340)3.28802066
44CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.27828561
45cellular response to ethanol (GO:0071361)3.23222104
46cellular response to type I interferon (GO:0071357)3.21711489
47type I interferon signaling pathway (GO:0060337)3.21711489
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.21544161
49positive regulation of interleukin-2 production (GO:0032743)3.17390335
50positive thymic T cell selection (GO:0045059)3.16782090
51alpha-beta T cell differentiation (GO:0046632)3.15662400
52regulation of mRNA catabolic process (GO:0061013)3.13749350
53cytokine biosynthetic process (GO:0042089)3.13712420
54regulation of regulatory T cell differentiation (GO:0045589)3.13687873
55regulation of alpha-beta T cell proliferation (GO:0046640)3.11849944
56positive regulation of immunoglobulin production (GO:0002639)3.08986670
57tolerance induction (GO:0002507)3.08718006
58hepatocyte apoptotic process (GO:0097284)3.08257477
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08121450
60negative regulation of bone remodeling (GO:0046851)3.07631432
61lymphocyte costimulation (GO:0031294)3.07201702
62cyclic nucleotide catabolic process (GO:0009214)3.05755885
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.05751957
64T-helper cell differentiation (GO:0042093)3.05751957
65cellular modified amino acid catabolic process (GO:0042219)3.02616964
66CD4-positive, alpha-beta T cell activation (GO:0035710)2.95495580
67T cell costimulation (GO:0031295)2.94584743
68regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.91181797
69mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.89960985
70positive regulation of interferon-alpha production (GO:0032727)2.89524541
71alpha-beta T cell activation (GO:0046631)2.89157829
72positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.87568293
73regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.87568293
74regulation of B cell differentiation (GO:0045577)2.85903130
75regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.85528506
76regulation of hippo signaling (GO:0035330)2.84928660
77chemokine-mediated signaling pathway (GO:0070098)2.83496876
78regulation of interferon-alpha production (GO:0032647)2.79747809
79galactose metabolic process (GO:0006012)2.79270170
80monoubiquitinated protein deubiquitination (GO:0035520)2.78741637
81negative regulation of alpha-beta T cell differentiation (GO:0046639)2.76165564
82mature B cell differentiation (GO:0002335)2.76112541
83positive regulation of circadian rhythm (GO:0042753)2.75973706
84positive regulation of T cell cytokine production (GO:0002726)2.74571534
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.73202723
86cAMP catabolic process (GO:0006198)2.71772574
87B cell receptor signaling pathway (GO:0050853)2.68880246
88regulation of isotype switching (GO:0045191)2.68689251
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67862480
90regulation of gamma-delta T cell differentiation (GO:0045586)2.66875991
91hydrogen peroxide biosynthetic process (GO:0050665)2.65704743
92neural tube formation (GO:0001841)2.65251371
93regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63605827
94positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63605827
95positive regulation of B cell activation (GO:0050871)2.63420787
96purinergic nucleotide receptor signaling pathway (GO:0035590)2.62614832
97T cell differentiation involved in immune response (GO:0002292)2.62271549
98alpha-beta T cell differentiation involved in immune response (GO:0002293)2.62271549
99alpha-beta T cell activation involved in immune response (GO:0002287)2.62271549
100interkinetic nuclear migration (GO:0022027)2.60923000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87177757
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79596150
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.74314860
4SMAD_19615063_ChIP-ChIP_OVARY_Human4.10856575
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.70284118
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.00948340
7SCL_19346495_ChIP-Seq_HPC-7_Human2.80335316
8RUNX_20019798_ChIP-Seq_JUKART_Human2.72845887
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.44980972
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.41626261
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39099744
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35835889
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.35558201
14VDR_22108803_ChIP-Seq_LS180_Human2.06702575
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.04497929
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04487788
17GATA3_26560356_Chip-Seq_TH2_Human2.01812657
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95448032
19MYB_26560356_Chip-Seq_TH2_Human1.90555578
20GATA3_27048872_Chip-Seq_THYMUS_Human1.87069677
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76374877
22MYB_26560356_Chip-Seq_TH1_Human1.73705983
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.71774856
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64470770
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.62616717
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.61165522
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60543600
28ZNF274_21170338_ChIP-Seq_K562_Hela1.60333103
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.59401521
30GBX2_23144817_ChIP-Seq_PC3_Human1.58539870
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56171133
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55903035
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55381945
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53589450
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50625354
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48808968
37CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45020752
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43563373
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43067314
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.40730849
41ER_23166858_ChIP-Seq_MCF-7_Human1.39712625
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34098432
43VDR_24787735_ChIP-Seq_THP-1_Human1.31268769
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30033758
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26783512
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22648914
47TP53_16413492_ChIP-PET_HCT116_Human1.22071794
48GATA1_22025678_ChIP-Seq_K562_Human1.20916554
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.20787658
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20601629
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20447989
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.19846124
53OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17979151
54BCAT_22108803_ChIP-Seq_LS180_Human1.17845041
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17538898
56IRF1_19129219_ChIP-ChIP_H3396_Human1.17317197
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.16788927
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16280467
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15756773
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15681922
61EGR1_19032775_ChIP-ChIP_M12_Human1.13810468
62MAF_26560356_Chip-Seq_TH1_Human1.13377539
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12955429
64STAT3_23295773_ChIP-Seq_U87_Human1.11229495
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08700828
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07537606
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07168823
68GATA3_26560356_Chip-Seq_TH1_Human1.04231552
69TAF15_26573619_Chip-Seq_HEK293_Human1.03505118
70SMRT_27268052_Chip-Seq_Bcells_Human1.03469041
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02169553
72CBP_20019798_ChIP-Seq_JUKART_Human1.02169553
73CDX2_22108803_ChIP-Seq_LS180_Human1.01612098
74FOXO3_23340844_ChIP-Seq_DLD1_Human0.99840623
75ARNT_22903824_ChIP-Seq_MCF-7_Human0.99335755
76AHR_22903824_ChIP-Seq_MCF-7_Human0.98147363
77SMAD4_21741376_ChIP-Seq_EPCs_Human0.97007043
78TCF4_22108803_ChIP-Seq_LS180_Human0.95104696
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95040951
80TCF4_23295773_ChIP-Seq_U87_Human0.93972135
81EWS_26573619_Chip-Seq_HEK293_Human0.93312612
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.93222417
83E2F1_18555785_Chip-Seq_ESCs_Mouse0.90949033
84P300_19829295_ChIP-Seq_ESCs_Human0.90414206
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88919864
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88902140
87FLI1_21867929_ChIP-Seq_TH2_Mouse0.87285583
88AR_25329375_ChIP-Seq_VCAP_Human0.87131524
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.85388761
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83709964
91SMAD4_21799915_ChIP-Seq_A2780_Human0.83097437
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82700713
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.82656497
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82655151
95IGF1R_20145208_ChIP-Seq_DFB_Human0.81859653
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.79998768
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79998768
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79872035
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79795941
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.79739536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation3.59647579
2MP0003763_abnormal_thymus_physiology3.49983973
3MP0001800_abnormal_humoral_immune3.32527673
4MP0003300_gastrointestinal_ulcer3.28912323
5MP0005670_abnormal_white_adipose3.23909851
6MP0008057_abnormal_DNA_replication3.02405442
7MP0000569_abnormal_digit_pigmentation2.96129211
8MP0005671_abnormal_response_to2.92133977
9MP0001790_abnormal_immune_system2.27772258
10MP0005387_immune_system_phenotype2.27772258
11MP0002723_abnormal_immune_serum2.26003336
12MP0002452_abnormal_antigen_presenting2.24650660
13MP0003866_abnormal_defecation2.23058493
14MP0005645_abnormal_hypothalamus_physiol2.21656327
15MP0001835_abnormal_antigen_presentation2.20862824
16MP0000685_abnormal_immune_system2.06848911
17MP0001819_abnormal_immune_cell2.05248040
18MP0002420_abnormal_adaptive_immunity2.04824125
19MP0005000_abnormal_immune_tolerance1.92026704
20MP0002009_preneoplasia1.91474205
21MP0005310_abnormal_salivary_gland1.87595979
22MP0002398_abnormal_bone_marrow1.86544157
23MP0003646_muscle_fatigue1.85843576
24MP0000015_abnormal_ear_pigmentation1.82600282
25MP0000716_abnormal_immune_system1.80616920
26MP0001501_abnormal_sleep_pattern1.79303448
27MP0000689_abnormal_spleen_morphology1.73781102
28MP0009333_abnormal_splenocyte_physiolog1.71518622
29MP0003183_abnormal_peptide_metabolism1.70994465
30MP0005025_abnormal_response_to1.63616494
31MP0002148_abnormal_hypersensitivity_rea1.58831760
32MP0003172_abnormal_lysosome_physiology1.54340808
33MP0002405_respiratory_system_inflammati1.53521870
34MP0009785_altered_susceptibility_to1.51805672
35MP0000703_abnormal_thymus_morphology1.44175360
36MP0002166_altered_tumor_susceptibility1.43880185
37MP0009764_decreased_sensitivity_to1.41699392
38MP0008872_abnormal_physiological_respon1.37953595
39MP0005075_abnormal_melanosome_morpholog1.37096055
40MP0000427_abnormal_hair_cycle1.35601341
41MP0008877_abnormal_DNA_methylation1.35491487
42MP0010386_abnormal_urinary_bladder1.35042089
43MP0002933_joint_inflammation1.33292243
44MP0002429_abnormal_blood_cell1.30983470
45MP0001845_abnormal_inflammatory_respons1.28885470
46MP0003950_abnormal_plasma_membrane1.28782260
47MP0002332_abnormal_exercise_endurance1.28639598
48MP0006035_abnormal_mitochondrial_morpho1.26709157
49MP0002876_abnormal_thyroid_physiology1.24885834
50MP0003137_abnormal_impulse_conducting1.23500327
51MP0010155_abnormal_intestine_physiology1.20680616
52MP0002722_abnormal_immune_system1.20642807
53MP0001986_abnormal_taste_sensitivity1.15277447
54MP0002693_abnormal_pancreas_physiology1.15023962
55MP0002653_abnormal_ependyma_morphology1.14718080
56MP0008995_early_reproductive_senescence1.09953144
57MP0003195_calcinosis1.09563049
58MP0004043_abnormal_pH_regulation1.02484887
59MP0000371_diluted_coat_color1.02450473
60MP0002163_abnormal_gland_morphology1.02406735
61MP0003436_decreased_susceptibility_to1.01279827
62MP0002396_abnormal_hematopoietic_system1.00609393
63MP0005167_abnormal_blood-brain_barrier0.99313329
64MP0004381_abnormal_hair_follicle0.98698396
65MP0009765_abnormal_xenobiotic_induced0.97961429
66MP0004947_skin_inflammation0.95793865
67MP0000538_abnormal_urinary_bladder0.94604130
68MP0005551_abnormal_eye_electrophysiolog0.93092486
69MP0005166_decreased_susceptibility_to0.91508243
70MP0002928_abnormal_bile_duct0.91267480
71MP0005266_abnormal_metabolism0.91055015
72MP0001502_abnormal_circadian_rhythm0.90630858
73MP0001764_abnormal_homeostasis0.90036286
74MP0002419_abnormal_innate_immunity0.89482971
75MP0001919_abnormal_reproductive_system0.88559010
76MP0008875_abnormal_xenobiotic_pharmacok0.88198748
77MP0002557_abnormal_social/conspecific_i0.85413529
78MP0005375_adipose_tissue_phenotype0.83773487
79MP0003045_fibrosis0.83767491
80MP0003786_premature_aging0.83422990
81MP0004142_abnormal_muscle_tone0.83327703
82MP0005330_cardiomyopathy0.81138483
83MP0002136_abnormal_kidney_physiology0.80622246
84MP0002971_abnormal_brown_adipose0.80025039
85MP0006082_CNS_inflammation0.77717698
86MP0001765_abnormal_ion_homeostasis0.76817652
87MP0001440_abnormal_grooming_behavior0.76655976
88MP0005379_endocrine/exocrine_gland_phen0.76614607
89MP0005174_abnormal_tail_pigmentation0.76152301
90MP0003787_abnormal_imprinting0.74781020
91MP0005666_abnormal_adipose_tissue0.73910064
92MP0002006_tumorigenesis0.72323510
93MP0002736_abnormal_nociception_after0.70870700
94MP0002638_abnormal_pupillary_reflex0.67932900
95MP0005389_reproductive_system_phenotype0.66928312
96MP0005620_abnormal_muscle_contractility0.65168714
97MP0008469_abnormal_protein_level0.64925359
98MP0001756_abnormal_urination0.64590753
99MP0003890_abnormal_embryonic-extraembry0.64129374
100MP0009115_abnormal_fat_cell0.64095028

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)7.84959949
2Stomatitis (HP:0010280)5.15440565
3Genetic anticipation (HP:0003743)4.45952783
4Abnormality of the prostate (HP:0008775)4.29632844
5Papilledema (HP:0001085)4.27385817
6Ureteral stenosis (HP:0000071)4.24366849
7Progressive inability to walk (HP:0002505)4.07214994
8Recurrent bronchitis (HP:0002837)4.05400470
9Ureteral obstruction (HP:0006000)3.92496441
10Spondylolisthesis (HP:0003302)3.72202609
11IgG deficiency (HP:0004315)3.70776620
12Diplopia (HP:0000651)3.67189448
13Abnormality of binocular vision (HP:0011514)3.67189448
14Mediastinal lymphadenopathy (HP:0100721)3.54342967
15Abnormality of alanine metabolism (HP:0010916)3.50867109
16Hyperalaninemia (HP:0003348)3.50867109
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50867109
18Panhypogammaglobulinemia (HP:0003139)3.47202125
19Agammaglobulinemia (HP:0004432)3.41412679
20Abnormality of the fingertips (HP:0001211)3.40117765
21Elevated erythrocyte sedimentation rate (HP:0003565)3.33455889
22Pulmonary infiltrates (HP:0002113)3.27263901
23Pulmonary fibrosis (HP:0002206)3.25335033
24Gastrointestinal infarctions (HP:0005244)3.22862993
25Dysmetric saccades (HP:0000641)3.21938498
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.02567237
27Meningitis (HP:0001287)3.01629292
28Obstructive lung disease (HP:0006536)2.98035781
29Chronic obstructive pulmonary disease (HP:0006510)2.98035781
30Gaze-evoked nystagmus (HP:0000640)2.93695017
31Poor speech (HP:0002465)2.86942752
32Stomach cancer (HP:0012126)2.84256208
33Abnormality of B cell number (HP:0010975)2.78805898
34Slow saccadic eye movements (HP:0000514)2.68563776
35B lymphocytopenia (HP:0010976)2.66165864
36Progressive cerebellar ataxia (HP:0002073)2.65677362
37Hip dysplasia (HP:0001385)2.63526697
38Neoplasm of the tracheobronchial system (HP:0100552)2.60068149
39Inability to walk (HP:0002540)2.59965885
40Widely spaced teeth (HP:0000687)2.55984564
41Abnormality of male internal genitalia (HP:0000022)2.55607103
42Alveolar cell carcinoma (HP:0006519)2.54427608
43Albinism (HP:0001022)2.50925705
44Fair hair (HP:0002286)2.44714624
45Congenital stationary night blindness (HP:0007642)2.43274560
46Thyroiditis (HP:0100646)2.38008260
47Vasculitis (HP:0002633)2.37568762
48Hypoplasia of the odontoid process (HP:0003311)2.36960262
49Neurodegeneration (HP:0002180)2.35283005
50Chronic sinusitis (HP:0011109)2.33167276
51Recurrent pneumonia (HP:0006532)2.30334524
52Abnormality of T cell physiology (HP:0011840)2.29957919
53Recurrent fungal infections (HP:0002841)2.26274037
54Recurrent sinusitis (HP:0011108)2.24571744
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.17477485
56Recurrent viral infections (HP:0004429)2.16041733
57J-shaped sella turcica (HP:0002680)2.15800100
58Restrictive lung disease (HP:0002091)2.12764723
59Prominent metopic ridge (HP:0005487)2.10452742
60Bronchitis (HP:0012387)2.10006697
61Papilloma (HP:0012740)2.09969285
62Verrucae (HP:0200043)2.09969285
63Pulmonary embolism (HP:0002204)2.06906966
64Polyneuropathy (HP:0001271)2.04366885
65Hemoptysis (HP:0002105)2.03786051
66Abnormality of T cells (HP:0002843)2.02785683
67Urinary bladder sphincter dysfunction (HP:0002839)2.02721317
68Generalized hypopigmentation of hair (HP:0011358)2.00860545
69Prostate neoplasm (HP:0100787)2.00187887
70Chronic hepatic failure (HP:0100626)1.99264039
71Abnormality of the metopic suture (HP:0005556)1.95995239
72Enlarged epiphyses (HP:0010580)1.95149165
73Aortic dissection (HP:0002647)1.94305263
74Amelogenesis imperfecta (HP:0000705)1.93462485
75Hematochezia (HP:0002573)1.93097256
76Abnormality of the pons (HP:0007361)1.89099128
77Alopecia of scalp (HP:0002293)1.88947120
78Hypoplasia of the pons (HP:0012110)1.87756939
79Gastrointestinal stroma tumor (HP:0100723)1.87741726
80IgA deficiency (HP:0002720)1.86549558
81Chest pain (HP:0100749)1.84818250
82Eczematoid dermatitis (HP:0000976)1.82994152
83Bicuspid aortic valve (HP:0001647)1.81677068
84Lymphoma (HP:0002665)1.81625367
85Severe combined immunodeficiency (HP:0004430)1.80259394
86Abnormality of the axillary hair (HP:0100134)1.79977507
87Abnormality of secondary sexual hair (HP:0009888)1.79977507
88Asplenia (HP:0001746)1.79030895
89Abnormality of T cell number (HP:0011839)1.78416470
90Bulbous nose (HP:0000414)1.78338297
91Abnormality of the odontoid process (HP:0003310)1.74918873
92Skin rash (HP:0000988)1.73822503
93Absent speech (HP:0001344)1.72172493
94Abnormality of the wing of the ilium (HP:0011867)1.71772239
95Abnormality of eosinophils (HP:0001879)1.71241324
96Disproportionate short-trunk short stature (HP:0003521)1.68944454
97Wide intermamillary distance (HP:0006610)1.68601721
98Flared iliac wings (HP:0002869)1.67361096
99Narrow palate (HP:0000189)1.66480745
100Follicular hyperkeratosis (HP:0007502)1.66159529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86956949
2AKT34.66663127
3TXK4.17373853
4ERBB43.58794397
5MST43.47687311
6EIF2AK12.87161453
7ITK2.79643796
8PDK22.60728506
9JAK32.50515141
10CDK82.16383772
11STK242.09339787
12STK38L2.03713577
13STK391.90595279
14MAP4K11.81934412
15GRK11.77221277
16BMPR1B1.74984778
17SIK31.63750217
18TEC1.60873724
19BTK1.47381426
20TYK21.43179764
21OXSR11.40748556
22TRIM281.37889441
23LCK1.37821937
24SGK21.37019175
25TAOK31.29888973
26BMPR21.24788442
27BCR1.23336390
28EIF2AK31.21063644
29JAK11.21023652
30IKBKE1.14162875
31IRAK41.13161460
32SGK31.10998941
33MAPK111.09232228
34KIT1.09171734
35IKBKB1.08609125
36ACVR1B1.08500175
37WNK41.06776525
38PAK31.03478755
39CAMKK21.02495009
40NLK1.01447146
41ADRBK20.94565220
42MELK0.93252853
43WNK10.89307616
44FGFR30.88004383
45FGFR20.87807825
46SGK2230.87721808
47SGK4940.87721808
48LYN0.86784396
49STK380.83799501
50MAPK130.82512621
51IGF1R0.82109392
52CAMK10.81004030
53MYLK0.80993473
54DAPK20.77864791
55CDK120.74578666
56ZAP700.69206190
57NUAK10.69191504
58CAMK1G0.68708054
59PBK0.68163961
60PIK3CA0.66245411
61PINK10.66153452
62SYK0.65387425
63CAMK40.64393594
64ZAK0.62662248
65IRAK10.61472670
66BRAF0.57761188
67MAPKAPK30.57647071
68FYN0.56695780
69PKN10.55843495
70SIK20.55634123
71BLK0.55030529
72CHUK0.52440569
73TGFBR10.51381932
74PIK3CG0.49853424
75PIM10.49829607
76MKNK20.49676296
77MAPK150.47815023
78OBSCN0.46697766
79BRSK20.46440506
80MAP2K60.46235529
81HCK0.44496493
82PRKAA10.43552999
83PNCK0.42666021
84MAP2K30.42633130
85CASK0.41999211
86PDGFRB0.41708136
87BRD40.40416541
88DAPK10.38832873
89PRKCZ0.33851716
90FGFR40.33073456
91CAMK1D0.32062899
92NTRK20.30961465
93MARK30.30176553
94GRK60.29782714
95RPS6KA50.28387277
96FER0.28187907
97NEK90.27688256
98ADRBK10.27508353
99RIPK40.27153562
100GSK3A0.26512864

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.88853609
2Autoimmune thyroid disease_Homo sapiens_hsa053203.74703762
3Allograft rejection_Homo sapiens_hsa053303.56314591
4T cell receptor signaling pathway_Homo sapiens_hsa046603.44236249
5Primary immunodeficiency_Homo sapiens_hsa053403.33180363
6Measles_Homo sapiens_hsa051622.89199149
7Graft-versus-host disease_Homo sapiens_hsa053322.57644228
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.55769350
9B cell receptor signaling pathway_Homo sapiens_hsa046622.50179561
10Asthma_Homo sapiens_hsa053102.46182791
11Hematopoietic cell lineage_Homo sapiens_hsa046402.40308683
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13612023
13Nitrogen metabolism_Homo sapiens_hsa009101.93702420
14Type I diabetes mellitus_Homo sapiens_hsa049401.83519511
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81801549
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75781615
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.66242646
18Circadian rhythm_Homo sapiens_hsa047101.52578839
19Osteoclast differentiation_Homo sapiens_hsa043801.44540379
20Lysine degradation_Homo sapiens_hsa003101.31015422
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.30554652
22Non-homologous end-joining_Homo sapiens_hsa034501.28496832
23Dorso-ventral axis formation_Homo sapiens_hsa043201.24317440
24Rheumatoid arthritis_Homo sapiens_hsa053231.23718065
25Butanoate metabolism_Homo sapiens_hsa006501.10509462
26TNF signaling pathway_Homo sapiens_hsa046681.09437369
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08215604
28Linoleic acid metabolism_Homo sapiens_hsa005911.06728121
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.05381818
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96357112
31ABC transporters_Homo sapiens_hsa020100.94668254
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93811675
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92545425
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.92476397
35Hepatitis C_Homo sapiens_hsa051600.91210027
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91155209
37Leishmaniasis_Homo sapiens_hsa051400.90064118
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89614925
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88832239
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87978604
41Basal transcription factors_Homo sapiens_hsa030220.87759078
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86846690
43Viral myocarditis_Homo sapiens_hsa054160.86178433
44Phototransduction_Homo sapiens_hsa047440.85460538
45Herpes simplex infection_Homo sapiens_hsa051680.80646917
46Influenza A_Homo sapiens_hsa051640.80186511
47Selenocompound metabolism_Homo sapiens_hsa004500.75510051
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73778014
49HTLV-I infection_Homo sapiens_hsa051660.73261078
50Nucleotide excision repair_Homo sapiens_hsa034200.73042962
51Chemokine signaling pathway_Homo sapiens_hsa040620.72837031
52Non-small cell lung cancer_Homo sapiens_hsa052230.72141983
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.70553442
54Staphylococcus aureus infection_Homo sapiens_hsa051500.70133718
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68762380
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68525901
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68358993
58Tuberculosis_Homo sapiens_hsa051520.66397983
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.63656882
60Olfactory transduction_Homo sapiens_hsa047400.63422973
61Glycerolipid metabolism_Homo sapiens_hsa005610.61322255
62Toxoplasmosis_Homo sapiens_hsa051450.61302737
63Viral carcinogenesis_Homo sapiens_hsa052030.61047215
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60290692
65Ether lipid metabolism_Homo sapiens_hsa005650.59386828
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58849670
67Calcium signaling pathway_Homo sapiens_hsa040200.57563418
68Taste transduction_Homo sapiens_hsa047420.55599725
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55017984
70Platelet activation_Homo sapiens_hsa046110.53845501
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52311389
72Hepatitis B_Homo sapiens_hsa051610.50263400
73Inositol phosphate metabolism_Homo sapiens_hsa005620.49305645
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48781941
75Acute myeloid leukemia_Homo sapiens_hsa052210.46121180
76FoxO signaling pathway_Homo sapiens_hsa040680.44700710
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.43454116
78Epstein-Barr virus infection_Homo sapiens_hsa051690.43139760
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42515666
80Renin secretion_Homo sapiens_hsa049240.42120648
81Homologous recombination_Homo sapiens_hsa034400.41652566
82Glucagon signaling pathway_Homo sapiens_hsa049220.39743319
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.39256671
84RNA degradation_Homo sapiens_hsa030180.39056711
85VEGF signaling pathway_Homo sapiens_hsa043700.38931226
86Insulin resistance_Homo sapiens_hsa049310.38116131
87Antigen processing and presentation_Homo sapiens_hsa046120.37755768
88Prostate cancer_Homo sapiens_hsa052150.36530185
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36135597
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34236112
91MAPK signaling pathway_Homo sapiens_hsa040100.31717690
92Serotonergic synapse_Homo sapiens_hsa047260.29662896
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.29185393
94Amphetamine addiction_Homo sapiens_hsa050310.28229744
95N-Glycan biosynthesis_Homo sapiens_hsa005100.26202184
96Lysosome_Homo sapiens_hsa041420.22041475
97cAMP signaling pathway_Homo sapiens_hsa040240.21311677
98Chemical carcinogenesis_Homo sapiens_hsa052040.21188341
99Fanconi anemia pathway_Homo sapiens_hsa034600.20960431
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20307896

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