MRPL39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.54350285
2chaperone-mediated protein transport (GO:0072321)4.21593562
3proteasome assembly (GO:0043248)4.08439561
4purine nucleobase biosynthetic process (GO:0009113)3.97638314
5maturation of SSU-rRNA (GO:0030490)3.96722024
6nucleobase biosynthetic process (GO:0046112)3.96596886
7DNA double-strand break processing (GO:0000729)3.96569077
8viral transcription (GO:0019083)3.91937101
9translational termination (GO:0006415)3.90167564
10ribosomal small subunit biogenesis (GO:0042274)3.88287406
11DNA strand elongation involved in DNA replication (GO:0006271)3.86771036
12kinetochore assembly (GO:0051382)3.83634237
13telomere maintenance via semi-conservative replication (GO:0032201)3.77189329
14protein neddylation (GO:0045116)3.76483885
15ribosomal large subunit biogenesis (GO:0042273)3.75620188
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73391455
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72628039
18ribosomal small subunit assembly (GO:0000028)3.71899032
19formation of translation preinitiation complex (GO:0001731)3.69595555
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67830953
21DNA strand elongation (GO:0022616)3.66436593
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62973862
23DNA replication initiation (GO:0006270)3.62754567
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60539898
25regulation of mitotic spindle checkpoint (GO:1903504)3.60539898
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60406155
27translational elongation (GO:0006414)3.60242594
28folic acid-containing compound biosynthetic process (GO:0009396)3.58295934
29CENP-A containing nucleosome assembly (GO:0034080)3.58079564
30chromatin remodeling at centromere (GO:0031055)3.57454791
31ribonucleoprotein complex biogenesis (GO:0022613)3.56806908
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.54966726
33termination of RNA polymerase III transcription (GO:0006386)3.54966726
34cullin deneddylation (GO:0010388)3.54066663
35protein complex biogenesis (GO:0070271)3.53065045
36mitochondrial respiratory chain complex assembly (GO:0033108)3.51679660
37metaphase plate congression (GO:0051310)3.47674655
38respiratory chain complex IV assembly (GO:0008535)3.47553522
39DNA ligation (GO:0006266)3.47051328
40translational initiation (GO:0006413)3.46816456
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45568791
42respiratory electron transport chain (GO:0022904)3.45548820
43replication fork processing (GO:0031297)3.45064484
44ribosome assembly (GO:0042255)3.44246115
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.44229463
46maturation of 5.8S rRNA (GO:0000460)3.43857487
47telomere maintenance via recombination (GO:0000722)3.43602951
48ribosome biogenesis (GO:0042254)3.42845075
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41573844
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.41573844
51NADH dehydrogenase complex assembly (GO:0010257)3.41573844
52spliceosomal snRNP assembly (GO:0000387)3.41286821
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41017294
54DNA catabolic process, exonucleolytic (GO:0000738)3.40880469
55protein localization to kinetochore (GO:0034501)3.40147609
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40060078
57electron transport chain (GO:0022900)3.38132378
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.37799923
59DNA replication-dependent nucleosome organization (GO:0034723)3.37415536
60DNA replication-dependent nucleosome assembly (GO:0006335)3.37415536
61cotranslational protein targeting to membrane (GO:0006613)3.33930631
62protein targeting to ER (GO:0045047)3.31234794
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31109991
64negative regulation of ligase activity (GO:0051352)3.31109991
65spindle checkpoint (GO:0031577)3.30329551
66pseudouridine synthesis (GO:0001522)3.30248835
67protein deneddylation (GO:0000338)3.29312113
68rRNA processing (GO:0006364)3.29051498
69regulation of ubiquitin-protein transferase activity (GO:0051438)3.28921103
70IMP biosynthetic process (GO:0006188)3.27234729
71histone mRNA metabolic process (GO:0008334)3.24916274
72rRNA modification (GO:0000154)3.24619616
73regulation of cellular amino acid metabolic process (GO:0006521)3.23704249
74ATP synthesis coupled proton transport (GO:0015986)3.22633772
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22633772
76protein targeting to mitochondrion (GO:0006626)3.22414323
77folic acid metabolic process (GO:0046655)3.22162296
78translation (GO:0006412)3.21713726
79mitotic recombination (GO:0006312)3.20804784
80DNA replication checkpoint (GO:0000076)3.19778760
81mitotic spindle checkpoint (GO:0071174)3.19708265
82oxidative phosphorylation (GO:0006119)3.19310697
83regulation of ligase activity (GO:0051340)3.18900699
84regulation of helicase activity (GO:0051095)3.17786538
85rRNA metabolic process (GO:0016072)3.17014194
86establishment of viral latency (GO:0019043)3.16686865
87protein localization to endoplasmic reticulum (GO:0070972)3.15904376
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15423076
89histone exchange (GO:0043486)3.15249434
90cytochrome complex assembly (GO:0017004)3.13585333
91establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12675530
92mitotic metaphase plate congression (GO:0007080)3.12633986
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.12558760
94negative regulation of sister chromatid segregation (GO:0033046)3.12558760
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12558760
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12558760
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12558760
98DNA replication-independent nucleosome organization (GO:0034724)3.11282250
99DNA replication-independent nucleosome assembly (GO:0006336)3.11282250
100cellular protein complex disassembly (GO:0043624)3.10946736
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10671823
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10128904
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10128904
104GTP biosynthetic process (GO:0006183)3.09768723
105regulation of mitochondrial translation (GO:0070129)3.08996851
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07868518
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07868518
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07868518
109mitotic sister chromatid segregation (GO:0000070)3.07751540
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06923275
111negative regulation of chromosome segregation (GO:0051985)3.06822851
112telomere maintenance via telomere lengthening (GO:0010833)3.05830612
113DNA damage response, detection of DNA damage (GO:0042769)3.05246726
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04759218
115signal transduction involved in DNA damage checkpoint (GO:0072422)3.04466165
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04466165
117establishment of protein localization to mitochondrial membrane (GO:0090151)3.04244608
118establishment of integrated proviral latency (GO:0075713)3.04133973
119cellular component biogenesis (GO:0044085)3.03318014
120spliceosomal complex assembly (GO:0000245)3.02358672
121viral life cycle (GO:0019058)3.02139238
122UTP biosynthetic process (GO:0006228)3.00634074
123protein localization to mitochondrion (GO:0070585)3.00394143
124somatic hypermutation of immunoglobulin genes (GO:0016446)3.00292937
125somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00292937
126rRNA methylation (GO:0031167)3.00134385
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.99816402
128pteridine-containing compound biosynthetic process (GO:0042559)2.99811670
129establishment of protein localization to mitochondrion (GO:0072655)2.96925403
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95082111
131IMP metabolic process (GO:0046040)2.93844352
132positive regulation of ligase activity (GO:0051351)2.92951868
133guanosine-containing compound biosynthetic process (GO:1901070)2.91940780
134chaperone-mediated protein complex assembly (GO:0051131)2.91773384
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.90430508
136glycine metabolic process (GO:0006544)2.89805424
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89424452
138transcription-coupled nucleotide-excision repair (GO:0006283)2.88235869
139kinetochore organization (GO:0051383)2.86771571
140serine family amino acid biosynthetic process (GO:0009070)2.86266583
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85771693
142amino acid salvage (GO:0043102)2.84604089
143L-methionine salvage (GO:0071267)2.84604089
144L-methionine biosynthetic process (GO:0071265)2.84604089
145DNA unwinding involved in DNA replication (GO:0006268)2.82570295
146UTP metabolic process (GO:0046051)2.82520267
147mitotic nuclear envelope disassembly (GO:0007077)2.80591459
148pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79164511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75920807
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36104069
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96281497
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76313865
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.49230342
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.48181828
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37397062
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.15854265
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09421482
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07768900
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03431621
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.89170177
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88589921
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87217629
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75099200
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66060229
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62789049
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60633057
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60081551
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.56932646
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54157241
22VDR_23849224_ChIP-Seq_CD4+_Human2.39772689
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34812495
24* XRN2_22483619_ChIP-Seq_HELA_Human2.34215451
25DCP1A_22483619_ChIP-Seq_HELA_Human2.29792436
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27694973
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25223751
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24396034
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.06311085
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.96502492
31AR_21909140_ChIP-Seq_LNCAP_Human1.94044218
32* GABP_19822575_ChIP-Seq_HepG2_Human1.92331248
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87001825
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86427088
35TTF2_22483619_ChIP-Seq_HELA_Human1.81536083
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80103877
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80026100
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79656011
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78207932
40ELK1_19687146_ChIP-ChIP_HELA_Human1.77897290
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72416815
42EWS_26573619_Chip-Seq_HEK293_Human1.71665653
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.69955149
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68418551
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.65406619
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63223257
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57615335
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53724418
49ZNF274_21170338_ChIP-Seq_K562_Hela1.53540780
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51888032
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50538096
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49969725
53VDR_22108803_ChIP-Seq_LS180_Human1.47864544
54FUS_26573619_Chip-Seq_HEK293_Human1.47321960
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45193854
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43815277
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.42449316
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40261448
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39128995
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37093753
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33457411
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.31789646
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29236377
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27147177
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26125656
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25626459
67KDM5A_27292631_Chip-Seq_BREAST_Human1.25151387
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.23955729
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22990139
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22390002
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19752555
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19368267
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19293144
74IGF1R_20145208_ChIP-Seq_DFB_Human1.18614861
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17567532
76CIITA_25753668_ChIP-Seq_RAJI_Human1.16974644
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16954908
78* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16857261
79* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14579548
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11935045
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11908385
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09223299
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08476844
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07020913
85* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06619952
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05500387
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05371051
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.05278713
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05083954
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.05080777
91MYC_18940864_ChIP-ChIP_HL60_Human1.04689400
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00838389
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99855192
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.97491700
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97340825
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97046138
97P300_19829295_ChIP-Seq_ESCs_Human0.96100631
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95717250
99TFEB_21752829_ChIP-Seq_HELA_Human0.94828203
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91996770
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91762540
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.89988047
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89279924
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89041848
105* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88331563
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87356227
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87058046
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85623396
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85242680
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82469777
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81915123
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80814897
113TAF15_26573619_Chip-Seq_HEK293_Human0.79830301
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79168233
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79010443
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76990476
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76803856
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76707944
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75624624
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.75503577
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75147306
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74818126
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74599221
124* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74555461
125IRF1_19129219_ChIP-ChIP_H3396_Human0.73974136
126TP53_22573176_ChIP-Seq_HFKS_Human0.72933222
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.70443624
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69457492
129NANOG_19829295_ChIP-Seq_ESCs_Human0.68365991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.91064483
2MP0003693_abnormal_embryo_hatching4.33007340
3MP0004957_abnormal_blastocyst_morpholog3.69354025
4MP0010094_abnormal_chromosome_stability3.67662557
5MP0003111_abnormal_nucleus_morphology3.22050349
6MP0003077_abnormal_cell_cycle3.19993803
7MP0008057_abnormal_DNA_replication3.11562003
8MP0008058_abnormal_DNA_repair2.95370493
9MP0008932_abnormal_embryonic_tissue2.55984565
10MP0006036_abnormal_mitochondrial_physio2.50261411
11MP0003186_abnormal_redox_activity2.47943997
12MP0002139_abnormal_hepatobiliary_system2.45502772
13MP0008007_abnormal_cellular_replicative2.36248615
14MP0009379_abnormal_foot_pigmentation2.23709458
15MP0002102_abnormal_ear_morphology2.21039506
16MP0000372_irregular_coat_pigmentation2.16129430
17MP0006292_abnormal_olfactory_placode2.10712176
18MP0001730_embryonic_growth_arrest2.05697078
19MP0006035_abnormal_mitochondrial_morpho1.99934484
20MP0003718_maternal_effect1.99928802
21MP0005410_abnormal_fertilization1.97359817
22MP0003221_abnormal_cardiomyocyte_apopto1.83568128
23MP0003646_muscle_fatigue1.82804258
24MP0006072_abnormal_retinal_apoptosis1.71997156
25MP0003786_premature_aging1.70782049
26MP0005085_abnormal_gallbladder_physiolo1.64453390
27MP0005360_urolithiasis1.59165497
28MP0000350_abnormal_cell_proliferation1.56758403
29MP0009697_abnormal_copulation1.50922507
30MP0004084_abnormal_cardiac_muscle1.43853438
31MP0004133_heterotaxia1.41179798
32MP0001929_abnormal_gametogenesis1.40897496
33MP0003567_abnormal_fetal_cardiomyocyte1.39873803
34MP0002210_abnormal_sex_determination1.39115262
35MP0008877_abnormal_DNA_methylation1.38681712
36MP0003937_abnormal_limbs/digits/tail_de1.36095700
37MP0003136_yellow_coat_color1.35670431
38MP0005266_abnormal_metabolism1.34542792
39MP0001697_abnormal_embryo_size1.32297809
40MP0005380_embryogenesis_phenotype1.30817681
41MP0001672_abnormal_embryogenesis/_devel1.30817681
42MP0002163_abnormal_gland_morphology1.29628122
43MP0002138_abnormal_hepatobiliary_system1.29295310
44MP0002736_abnormal_nociception_after1.29279053
45MP0004145_abnormal_muscle_electrophysio1.28802948
46MP0003123_paternal_imprinting1.28071985
47MP0005365_abnormal_bile_salt1.26290471
48MP0002080_prenatal_lethality1.25977253
49MP0000358_abnormal_cell_content/1.24604713
50MP0003984_embryonic_growth_retardation1.22124687
51MP0001145_abnormal_male_reproductive1.22053593
52MP0002090_abnormal_vision1.21367713
53MP0001764_abnormal_homeostasis1.19497968
54MP0005332_abnormal_amino_acid1.19220523
55MP0005253_abnormal_eye_physiology1.18820787
56MP0002088_abnormal_embryonic_growth/wei1.18488391
57MP0002396_abnormal_hematopoietic_system1.18337658
58MP0000313_abnormal_cell_death1.15713965
59MP0008875_abnormal_xenobiotic_pharmacok1.14681985
60MP0005330_cardiomyopathy1.13860560
61MP0009053_abnormal_anal_canal1.13337735
62MP0002160_abnormal_reproductive_system1.12231858
63MP0010307_abnormal_tumor_latency1.11964907
64MP0002132_abnormal_respiratory_system1.11566917
65MP0003656_abnormal_erythrocyte_physiolo1.10584698
66MP0005670_abnormal_white_adipose1.09571338
67MP0005084_abnormal_gallbladder_morpholo1.08971802
68MP0005395_other_phenotype1.08284631
69MP0002234_abnormal_pharynx_morphology1.08210237
70MP0005319_abnormal_enzyme/_coenzyme1.06184018
71MP0008995_early_reproductive_senescence1.04965093
72MP0003698_abnormal_male_reproductive1.02267343
73MP0000490_abnormal_crypts_of1.02265970
74MP0000653_abnormal_sex_gland1.01606979
75MP0002751_abnormal_autonomic_nervous1.00678163
76MP0002019_abnormal_tumor_incidence1.00430518
77MP0002085_abnormal_embryonic_tissue1.00240080
78MP0003195_calcinosis0.98044145
79MP0004147_increased_porphyrin_level0.96763099
80MP0005379_endocrine/exocrine_gland_phen0.96146294
81MP0000516_abnormal_urinary_system0.95843997
82MP0005367_renal/urinary_system_phenotyp0.95843997
83MP0008789_abnormal_olfactory_epithelium0.94924140
84MP0005551_abnormal_eye_electrophysiolog0.94655860
85MP0008872_abnormal_physiological_respon0.93054882
86MP0003121_genomic_imprinting0.92941424
87MP0003119_abnormal_digestive_system0.91991005
88MP0001984_abnormal_olfaction0.89507694
89MP0003252_abnormal_bile_duct0.88804291
90MP0000750_abnormal_muscle_regeneration0.87488932
91MP0000749_muscle_degeneration0.86072328
92MP0001293_anophthalmia0.85535625
93MP0004197_abnormal_fetal_growth/weight/0.84863434
94MP0002084_abnormal_developmental_patter0.84647685
95MP0003137_abnormal_impulse_conducting0.83785554
96MP0001286_abnormal_eye_development0.83495716
97MP0005075_abnormal_melanosome_morpholog0.83252317
98MP0004215_abnormal_myocardial_fiber0.81655608
99MP0001119_abnormal_female_reproductive0.81511519
100MP0000647_abnormal_sebaceous_gland0.80966780
101MP0002269_muscular_atrophy0.80908959
102MP0005408_hypopigmentation0.79415276
103MP0003880_abnormal_central_pattern0.79274056
104MP0001727_abnormal_embryo_implantation0.78171806
105MP0002086_abnormal_extraembryonic_tissu0.77844911
106MP0010030_abnormal_orbit_morphology0.77764126
107MP0002254_reproductive_system_inflammat0.77392014
108MP0002233_abnormal_nose_morphology0.77270404
109MP0009333_abnormal_splenocyte_physiolog0.77112471
110MP0005389_reproductive_system_phenotype0.76979082
111MP0003941_abnormal_skin_development0.75396470
112MP0000598_abnormal_liver_morphology0.75027865
113MP0005451_abnormal_body_composition0.73375002
114MP0000631_abnormal_neuroendocrine_gland0.72921610
115MP0001853_heart_inflammation0.72722605
116MP0003011_delayed_dark_adaptation0.72720703
117MP0005083_abnormal_biliary_tract0.71578983
118MP0003890_abnormal_embryonic-extraembry0.71568215
119MP0002111_abnormal_tail_morphology0.71474603
120MP0002653_abnormal_ependyma_morphology0.71088793
121MP0001529_abnormal_vocalization0.70542695
122MP0005391_vision/eye_phenotype0.70352799
123MP0005376_homeostasis/metabolism_phenot0.69840841
124MP0006054_spinal_hemorrhage0.69742653
125MP0003315_abnormal_perineum_morphology0.69527140
126MP0002837_dystrophic_cardiac_calcinosis0.69310799
127MP0002161_abnormal_fertility/fecundity0.68834913
128MP0004142_abnormal_muscle_tone0.67690917
129MP0000609_abnormal_liver_physiology0.67263148
130MP0001485_abnormal_pinna_reflex0.66668258
131MP0002095_abnormal_skin_pigmentation0.64641394
132MP0009672_abnormal_birth_weight0.64503605
133MP0008873_increased_physiological_sensi0.63974486
134MP0005385_cardiovascular_system_phenoty0.63501996
135MP0001544_abnormal_cardiovascular_syste0.63501996
136MP0002938_white_spotting0.62602989
137MP0004036_abnormal_muscle_relaxation0.61581896
138MP0005636_abnormal_mineral_homeostasis0.61266220
139MP0005666_abnormal_adipose_tissue0.58883154
140MP0003950_abnormal_plasma_membrane0.58829819
141MP0001545_abnormal_hematopoietic_system0.58740526
142MP0005397_hematopoietic_system_phenotyp0.58740526

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)4.17226289
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.17226289
3Hepatic necrosis (HP:0002605)4.03903335
4Acute necrotizing encephalopathy (HP:0006965)3.89467505
5Hepatocellular necrosis (HP:0001404)3.83556072
6Reticulocytopenia (HP:0001896)3.78636962
7Abnormal mitochondria in muscle tissue (HP:0008316)3.73136532
8Birth length less than 3rd percentile (HP:0003561)3.67617833
9Mitochondrial inheritance (HP:0001427)3.64308829
10Abnormality of glycolysis (HP:0004366)3.61951772
11Increased serum pyruvate (HP:0003542)3.61951772
12Increased CSF lactate (HP:0002490)3.58684115
13Acute encephalopathy (HP:0006846)3.56863440
14Abnormality of cells of the erythroid lineage (HP:0012130)3.40260886
15Lipid accumulation in hepatocytes (HP:0006561)3.38496326
16Increased hepatocellular lipid droplets (HP:0006565)3.33134951
17Cerebral edema (HP:0002181)3.31561251
18Multiple enchondromatosis (HP:0005701)3.30707349
19Increased serum lactate (HP:0002151)3.28944385
20Macrocytic anemia (HP:0001972)3.28930192
21Abnormal number of erythroid precursors (HP:0012131)3.22197255
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09500436
23Abnormality of the ileum (HP:0001549)3.08951865
24Oral leukoplakia (HP:0002745)3.05340602
25Breast hypoplasia (HP:0003187)3.00785135
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00144958
27Dicarboxylic aciduria (HP:0003215)2.97430729
28Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97430729
29Cerebral hypomyelination (HP:0006808)2.95706807
30Increased intramyocellular lipid droplets (HP:0012240)2.95544224
31Progressive macrocephaly (HP:0004481)2.92983906
32Increased muscle lipid content (HP:0009058)2.91895119
33Methylmalonic acidemia (HP:0002912)2.91249828
34Lactic acidosis (HP:0003128)2.90831388
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.90772323
36Chromsome breakage (HP:0040012)2.90659505
37Abnormality of the labia minora (HP:0012880)2.87245912
38Hyperglycinemia (HP:0002154)2.79950053
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76277921
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70400224
413-Methylglutaconic aciduria (HP:0003535)2.70100277
42Exercise intolerance (HP:0003546)2.69156117
43Hyperglycinuria (HP:0003108)2.67223064
44Nausea (HP:0002018)2.65534960
45Respiratory failure (HP:0002878)2.64136441
46Rhabdomyolysis (HP:0003201)2.63282363
47Abnormality of serine family amino acid metabolism (HP:0010894)2.59880622
48Abnormality of glycine metabolism (HP:0010895)2.59880622
49Degeneration of anterior horn cells (HP:0002398)2.59381147
50Abnormality of the anterior horn cell (HP:0006802)2.59381147
51Microvesicular hepatic steatosis (HP:0001414)2.59292549
52Type I transferrin isoform profile (HP:0003642)2.57980441
53Abnormality of serum amino acid levels (HP:0003112)2.56993484
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56584252
55Lethargy (HP:0001254)2.53002884
56Abnormal lung lobation (HP:0002101)2.51737025
57Pallor (HP:0000980)2.51311779
58Rough bone trabeculation (HP:0100670)2.49959223
59Hypobetalipoproteinemia (HP:0003563)2.47099690
60Small intestinal stenosis (HP:0012848)2.46159086
61Duodenal stenosis (HP:0100867)2.46159086
62CNS demyelination (HP:0007305)2.45511137
63Neoplasm of the adrenal gland (HP:0100631)2.44204342
64Aplastic anemia (HP:0001915)2.44017817
65Abnormality of alanine metabolism (HP:0010916)2.42740885
66Hyperalaninemia (HP:0003348)2.42740885
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42740885
68Abnormal respiratory motile cilium morphology (HP:0005938)2.36190973
69Abnormal respiratory epithelium morphology (HP:0012253)2.36190973
70Reduced antithrombin III activity (HP:0001976)2.34693919
71Generalized aminoaciduria (HP:0002909)2.32937669
72Megaloblastic anemia (HP:0001889)2.32817739
73Pancytopenia (HP:0001876)2.32813391
74Abnormality of pyrimidine metabolism (HP:0004353)2.31359253
75Exertional dyspnea (HP:0002875)2.29570104
76Pancreatic cysts (HP:0001737)2.28943555
77Ependymoma (HP:0002888)2.28107976
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27699793
79Respiratory difficulties (HP:0002880)2.25435999
80Abnormality of the duodenum (HP:0002246)2.23662765
81Methylmalonic aciduria (HP:0012120)2.23201526
82Abnormality of fatty-acid metabolism (HP:0004359)2.16619940
83Optic disc pallor (HP:0000543)2.16587392
84Hyperammonemia (HP:0001987)2.16064125
85Glioma (HP:0009733)2.14567515
86Pancreatic fibrosis (HP:0100732)2.11712956
87Carpal bone hypoplasia (HP:0001498)2.10973820
88Selective tooth agenesis (HP:0001592)2.10827845
89Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10369861
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10034063
91Abnormal protein N-linked glycosylation (HP:0012347)2.10034063
92Abnormal protein glycosylation (HP:0012346)2.10034063
93Abnormal glycosylation (HP:0012345)2.10034063
94Secondary amenorrhea (HP:0000869)2.09122994
95Abnormal respiratory motile cilium physiology (HP:0012261)2.07674110
96Renal Fanconi syndrome (HP:0001994)2.06733033
97Proximal tubulopathy (HP:0000114)2.06642402
98Absent/shortened dynein arms (HP:0200106)2.03819045
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.03819045
100Abnormality of urine glucose concentration (HP:0011016)2.02575045
101Glycosuria (HP:0003076)2.02575045
102Leukodystrophy (HP:0002415)2.02337978
103Trismus (HP:0000211)2.00973330
104Emotional lability (HP:0000712)2.00700707
105Sloping forehead (HP:0000340)1.99754293
106True hermaphroditism (HP:0010459)1.98946405
107Abnormality of chromosome stability (HP:0003220)1.97493460
108Hypoglycemic coma (HP:0001325)1.97241848
109Congenital, generalized hypertrichosis (HP:0004540)1.97179254
110Supernumerary spleens (HP:0009799)1.96236399
111Abnormality of methionine metabolism (HP:0010901)1.95678703
112Microretrognathia (HP:0000308)1.95517349
113Abnormal trabecular bone morphology (HP:0100671)1.95266793
114Abnormal spermatogenesis (HP:0008669)1.94172999
115Colon cancer (HP:0003003)1.93940287
116Absent thumb (HP:0009777)1.93294941
117Pancreatic islet-cell hyperplasia (HP:0004510)1.92195773
118Neoplasm of the adrenal cortex (HP:0100641)1.90244057
119Triphalangeal thumb (HP:0001199)1.89267699
120Abnormality of the pons (HP:0007361)1.89047776
121Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88111885
122Patellar aplasia (HP:0006443)1.88005306
123Abnormal hemoglobin (HP:0011902)1.87784102
124Meckel diverticulum (HP:0002245)1.86834028
125Ragged-red muscle fibers (HP:0003200)1.86396075
126Abnormality of the preputium (HP:0100587)1.85400501
127Hypoplasia of the pons (HP:0012110)1.85161520
128Progressive external ophthalmoplegia (HP:0000590)1.84934074
129Neoplasm of the colon (HP:0100273)1.84863452
130Myelodysplasia (HP:0002863)1.84085186
131Impulsivity (HP:0100710)1.83985689
132Embryonal renal neoplasm (HP:0011794)1.83929112
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.83071034
134Palpitations (HP:0001962)1.79949252
135Clubbing of toes (HP:0100760)1.79823924
136Cleft eyelid (HP:0000625)1.79675503
137Nephroblastoma (Wilms tumor) (HP:0002667)1.79077985
138Abnormality of vitamin B metabolism (HP:0004340)1.78221028
139Rhabdomyosarcoma (HP:0002859)1.77906739
140Abnormality of homocysteine metabolism (HP:0010919)1.76753245
141Homocystinuria (HP:0002156)1.76753245
142Abnormality of the astrocytes (HP:0100707)1.76238156
143Astrocytoma (HP:0009592)1.76238156
144Hyperinsulinemic hypoglycemia (HP:0000825)1.76220729
145Intestinal atresia (HP:0011100)1.74837785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41754536
2WEE14.20485563
3EIF2AK14.16343834
4VRK23.40401829
5STK163.29016311
6NME23.19467174
7PDK32.64258396
8PDK42.64258396
9BCKDK2.61109280
10CDC72.55198935
11SRPK12.38718216
12TESK22.38028279
13PLK42.35984451
14TRIM282.35489492
15VRK12.25922096
16NEK12.05624408
17WNK32.00108653
18EIF2AK31.96924009
19BRSK21.96287448
20TLK11.94578895
21TNIK1.88310555
22BMPR1B1.86796226
23TTK1.82996219
24TESK11.75313499
25PBK1.74139320
26NEK21.71313996
27TAF11.68481354
28PLK11.64398862
29TSSK61.64377023
30DYRK31.62881551
31PDK21.56725866
32ZAK1.48124680
33PIM21.42603154
34MKNK11.35046016
35NME11.34458325
36AURKB1.31609150
37CDK71.26292848
38FRK1.25871365
39AURKA1.24200797
40ACVR1B1.24064564
41ATR1.15766944
42MAP3K81.14553186
43PLK31.14435848
44RPS6KB21.13813511
45PNCK1.08785767
46RPS6KA41.07916229
47KDR1.06845781
48MKNK21.06313934
49PLK21.05678307
50LIMK11.04576421
51PASK1.02641077
52ERBB31.00565017
53STK38L0.97371693
54FLT30.96761510
55GRK10.96302318
56MAP4K20.94062354
57BRAF0.93502176
58BRSK10.89097613
59CHEK20.83745373
60MAP3K120.80796463
61STK40.80743771
62STK100.80732831
63OBSCN0.79746181
64CSNK1G20.79386461
65CSNK2A20.78872231
66EIF2AK20.77183698
67CCNB10.76154393
68CSNK2A10.75206506
69PAK40.72062632
70CHEK10.71974601
71MST40.70052910
72PAK10.69752325
73CSNK1A1L0.68519252
74OXSR10.68386981
75RPS6KA50.67848838
76CDK40.67109490
77NEK90.64477271
78ARAF0.64322639
79EPHA20.63471496
80MYLK0.63437612
81SCYL20.61848489
82TGFBR10.59920020
83ABL20.59273585
84ATM0.57560751
85MAP3K110.57074819
86MAP3K40.55121119
87DYRK20.53451550
88PIM10.52662233
89YES10.50706459
90DAPK10.50275947
91ILK0.50081728
92MAPKAPK30.48692921
93CDK190.47694196
94NUAK10.47424201
95MUSK0.45488053
96ALK0.44539219
97DYRK1B0.44475776
98PKN20.43620479
99ADRBK20.43038881
100CDK80.42907162
101CDK20.41114626
102FGFR10.38728087
103ERBB40.37658495
104TEC0.37586861
105SIK30.36605371
106PRKCE0.34935763
107CSNK1G30.33734516
108INSRR0.33467206
109DAPK30.33404454
110LRRK20.33255441
111PRKCG0.32654395
112TIE10.32142042
113MAPKAPK50.31969676
114MAP3K30.31683129
115CDK10.31562393
116PINK10.31093535
117BCR0.30359544
118PRKDC0.29499140
119MINK10.29029702
120MAP2K70.28998304
121AKT20.28397445
122CSNK1A10.27325202
123MELK0.27007825
124GRK70.26760869
125LATS10.24343906
126CSNK1E0.24167345
127STK240.24062330
128MAPK130.23841019
129STK30.21713004
130MARK30.18436497
131MAP3K50.17089342
132STK390.17009706
133IRAK10.15137824
134CSNK1G10.14649528
135PRKCI0.14253307

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.69438713
2Ribosome_Homo sapiens_hsa030103.50059382
3DNA replication_Homo sapiens_hsa030303.44453892
4Mismatch repair_Homo sapiens_hsa034302.98983278
5RNA polymerase_Homo sapiens_hsa030202.98204858
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79666692
7Spliceosome_Homo sapiens_hsa030402.45409741
8One carbon pool by folate_Homo sapiens_hsa006702.38398583
9Pyrimidine metabolism_Homo sapiens_hsa002402.30026181
10RNA transport_Homo sapiens_hsa030132.21961528
11Homologous recombination_Homo sapiens_hsa034402.17282772
12Nucleotide excision repair_Homo sapiens_hsa034202.16399819
13Oxidative phosphorylation_Homo sapiens_hsa001902.05206473
14Parkinsons disease_Homo sapiens_hsa050122.00107888
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96900043
16Base excision repair_Homo sapiens_hsa034101.95490797
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79716129
18Huntingtons disease_Homo sapiens_hsa050161.71787565
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68431744
20Folate biosynthesis_Homo sapiens_hsa007901.67353870
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61250023
22Carbon metabolism_Homo sapiens_hsa012001.60349971
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57252920
24Propanoate metabolism_Homo sapiens_hsa006401.52945107
25Basal transcription factors_Homo sapiens_hsa030221.51515165
26Cell cycle_Homo sapiens_hsa041101.50783903
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.49109566
28Biosynthesis of amino acids_Homo sapiens_hsa012301.45704586
29Fanconi anemia pathway_Homo sapiens_hsa034601.42890398
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42309510
31Non-homologous end-joining_Homo sapiens_hsa034501.40230657
32Pyruvate metabolism_Homo sapiens_hsa006201.36186148
33Protein export_Homo sapiens_hsa030601.36111480
34Vitamin B6 metabolism_Homo sapiens_hsa007501.35291621
35Pentose phosphate pathway_Homo sapiens_hsa000301.30077589
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28105786
37Selenocompound metabolism_Homo sapiens_hsa004501.27141721
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.25472473
39RNA degradation_Homo sapiens_hsa030181.25289195
40Purine metabolism_Homo sapiens_hsa002301.24833739
41Glutathione metabolism_Homo sapiens_hsa004801.24207271
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19429845
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14864125
44Fatty acid degradation_Homo sapiens_hsa000711.12418602
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09068416
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.07103494
47Alzheimers disease_Homo sapiens_hsa050101.05900619
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05576922
49Sulfur relay system_Homo sapiens_hsa041221.03984783
50Systemic lupus erythematosus_Homo sapiens_hsa053220.96655397
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94990814
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.94574538
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93872328
54Fatty acid elongation_Homo sapiens_hsa000620.91138453
55Peroxisome_Homo sapiens_hsa041460.87738166
56Epstein-Barr virus infection_Homo sapiens_hsa051690.85842066
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83255624
58p53 signaling pathway_Homo sapiens_hsa041150.79125540
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77797902
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75292134
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74827396
62Metabolic pathways_Homo sapiens_hsa011000.74638224
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73183552
64mRNA surveillance pathway_Homo sapiens_hsa030150.71548539
65Fructose and mannose metabolism_Homo sapiens_hsa000510.69731990
66Fatty acid metabolism_Homo sapiens_hsa012120.68907705
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67719404
68Chemical carcinogenesis_Homo sapiens_hsa052040.66157920
69Arginine and proline metabolism_Homo sapiens_hsa003300.64015634
70Cardiac muscle contraction_Homo sapiens_hsa042600.63049058
71Butanoate metabolism_Homo sapiens_hsa006500.62134899
72Tryptophan metabolism_Homo sapiens_hsa003800.62046842
73beta-Alanine metabolism_Homo sapiens_hsa004100.61075470
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59379537
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58341958
76N-Glycan biosynthesis_Homo sapiens_hsa005100.54372479
77Phototransduction_Homo sapiens_hsa047440.54077152
78Sulfur metabolism_Homo sapiens_hsa009200.52443008
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51613521
80Caffeine metabolism_Homo sapiens_hsa002320.48235550
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47937957
82Nitrogen metabolism_Homo sapiens_hsa009100.46660142
83Phenylalanine metabolism_Homo sapiens_hsa003600.45374277
84Tyrosine metabolism_Homo sapiens_hsa003500.44963716
85Legionellosis_Homo sapiens_hsa051340.44186138
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42988941
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42187941
88Vitamin digestion and absorption_Homo sapiens_hsa049770.41505933
89Retinol metabolism_Homo sapiens_hsa008300.40802629
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.39806840
91Viral carcinogenesis_Homo sapiens_hsa052030.35519642
92Galactose metabolism_Homo sapiens_hsa000520.34099189
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33259679
94Herpes simplex infection_Homo sapiens_hsa051680.33248025
95Steroid biosynthesis_Homo sapiens_hsa001000.32623255
96PPAR signaling pathway_Homo sapiens_hsa033200.32353818
97Histidine metabolism_Homo sapiens_hsa003400.32076649
98Collecting duct acid secretion_Homo sapiens_hsa049660.31841982
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.31684094
100Antigen processing and presentation_Homo sapiens_hsa046120.31180327
101Linoleic acid metabolism_Homo sapiens_hsa005910.30658414
102Oocyte meiosis_Homo sapiens_hsa041140.28827715
103Fat digestion and absorption_Homo sapiens_hsa049750.28501281
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27867295
105Regulation of autophagy_Homo sapiens_hsa041400.27494434
106Starch and sucrose metabolism_Homo sapiens_hsa005000.27189336
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27189266
108Arachidonic acid metabolism_Homo sapiens_hsa005900.26217921
109TGF-beta signaling pathway_Homo sapiens_hsa043500.22063531
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21259940
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19835816
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11640182
113Ether lipid metabolism_Homo sapiens_hsa005650.08419229
114Olfactory transduction_Homo sapiens_hsa047400.08091938

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