MRPL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.41974604
2ribosomal small subunit assembly (GO:0000028)5.26201093
3proline biosynthetic process (GO:0006561)4.87822915
4proteasome assembly (GO:0043248)4.79639066
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.78583780
6peptidyl-arginine omega-N-methylation (GO:0035247)4.52463464
7oxidative phosphorylation (GO:0006119)4.47459207
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39754789
9ATP synthesis coupled proton transport (GO:0015986)4.39754789
10maturation of SSU-rRNA (GO:0030490)4.36529931
11DNA unwinding involved in DNA replication (GO:0006268)4.34345686
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22952140
13viral transcription (GO:0019083)4.22932024
14regulation of translational fidelity (GO:0006450)4.22251387
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.21452715
16nucleobase biosynthetic process (GO:0046112)4.20670352
17formation of translation preinitiation complex (GO:0001731)4.18740443
18termination of RNA polymerase III transcription (GO:0006386)4.17343309
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.17343309
20purine nucleobase biosynthetic process (GO:0009113)4.13852750
21translational termination (GO:0006415)4.13045012
22ribosomal small subunit biogenesis (GO:0042274)4.10478462
23regulation of translational termination (GO:0006449)4.00654603
24protein maturation by protein folding (GO:0022417)3.98423274
25DNA strand elongation involved in DNA replication (GO:0006271)3.96719841
26translational elongation (GO:0006414)3.94671423
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93445706
28telomere maintenance via semi-conservative replication (GO:0032201)3.90672606
29histone arginine methylation (GO:0034969)3.90262975
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90145633
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.86732865
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83076997
33negative regulation of ligase activity (GO:0051352)3.83076997
34DNA strand elongation (GO:0022616)3.82567200
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.82340902
36regulation of cellular amino acid metabolic process (GO:0006521)3.81189591
37ribosome biogenesis (GO:0042254)3.80735039
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.79239877
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78763590
40ribonucleoprotein complex biogenesis (GO:0022613)3.78279014
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77981848
42cullin deneddylation (GO:0010388)3.75101873
43GDP-mannose metabolic process (GO:0019673)3.74215504
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.72152102
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.72152102
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.71865559
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.71865559
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.71865559
49regulation of mitochondrial translation (GO:0070129)3.71599280
50protein deneddylation (GO:0000338)3.70354885
51pseudouridine synthesis (GO:0001522)3.68143722
52translational initiation (GO:0006413)3.67966575
53cotranslational protein targeting to membrane (GO:0006613)3.67266349
54protein targeting to ER (GO:0045047)3.64299680
55ribosomal large subunit biogenesis (GO:0042273)3.64040715
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63155935
57signal transduction involved in DNA damage checkpoint (GO:0072422)3.63155935
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.62114976
59tricarboxylic acid cycle (GO:0006099)3.61556523
60rRNA modification (GO:0000154)3.61378427
61L-methionine salvage (GO:0071267)3.59931763
62L-methionine biosynthetic process (GO:0071265)3.59931763
63amino acid salvage (GO:0043102)3.59931763
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59135548
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.59135548
66NADH dehydrogenase complex assembly (GO:0010257)3.59135548
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.57178143
68viral mRNA export from host cell nucleus (GO:0046784)3.56868167
69* translation (GO:0006412)3.56772607
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56305524
71peptidyl-arginine N-methylation (GO:0035246)3.56200567
72peptidyl-arginine methylation (GO:0018216)3.56200567
73NADH metabolic process (GO:0006734)3.55383924
74mitotic nuclear envelope reassembly (GO:0007084)3.54223850
75nuclear envelope reassembly (GO:0031468)3.54223850
76DNA replication initiation (GO:0006270)3.53524613
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.52951962
78cellular component biogenesis (GO:0044085)3.50156240
79protein localization to endoplasmic reticulum (GO:0070972)3.49056977
80transcription from mitochondrial promoter (GO:0006390)3.46193362
81pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.45263454
82proline metabolic process (GO:0006560)3.44706571
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44624131
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44333313
85respiratory electron transport chain (GO:0022904)3.44163945
86spliceosomal tri-snRNP complex assembly (GO:0000244)3.41312628
87rRNA transcription (GO:0009303)3.40893846
88DNA replication checkpoint (GO:0000076)3.39483363
89protein complex biogenesis (GO:0070271)3.38849072
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.38833293
91telomere maintenance via recombination (GO:0000722)3.37616566
92pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.37518255
93spliceosomal snRNP assembly (GO:0000387)3.36616831
94electron transport chain (GO:0022900)3.35817984
95UTP biosynthetic process (GO:0006228)3.34730125
96ncRNA 3-end processing (GO:0043628)3.34023350
97rRNA processing (GO:0006364)3.33914700
98mitochondrial fusion (GO:0008053)3.32390907
99mitochondrial respiratory chain complex assembly (GO:0033108)3.31830379
100cellular protein complex disassembly (GO:0043624)3.31525772
101peptidyl-histidine modification (GO:0018202)3.31422282
102metallo-sulfur cluster assembly (GO:0031163)3.29908714
103iron-sulfur cluster assembly (GO:0016226)3.29908714
104positive regulation of ligase activity (GO:0051351)3.29588460
105mitochondrial RNA metabolic process (GO:0000959)3.28236242
1067-methylguanosine mRNA capping (GO:0006370)3.26078393
107guanosine-containing compound biosynthetic process (GO:1901070)3.26064574
108folic acid metabolic process (GO:0046655)3.25400146
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24965474
110viral life cycle (GO:0019058)3.24804990
111pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.22531005
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21696549
113rRNA metabolic process (GO:0016072)3.21683521
114RNA capping (GO:0036260)3.17615712
1157-methylguanosine RNA capping (GO:0009452)3.17615712
116protein targeting to mitochondrion (GO:0006626)3.17238170
117transcription-coupled nucleotide-excision repair (GO:0006283)3.16297213
118nucleobase-containing small molecule interconversion (GO:0015949)3.15102917
119establishment of protein localization to mitochondrion (GO:0072655)3.15034023
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13564801
121folic acid-containing compound biosynthetic process (GO:0009396)3.12614648
122tRNA methylation (GO:0030488)3.11544519
123mitotic chromosome condensation (GO:0007076)3.10862404
124positive regulation of cell cycle arrest (GO:0071158)3.07695979
125telomere maintenance via telomere lengthening (GO:0010833)3.06331868
126regulation of ubiquitin-protein transferase activity (GO:0051438)3.05743505
127UTP metabolic process (GO:0046051)3.02229787
128negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.01089032
129pentose metabolic process (GO:0019321)3.00561711
130DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.00556370
131ribosome assembly (GO:0042255)3.00371286
132pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.99225446
133cell cycle G1/S phase transition (GO:0044843)2.97910931
134G1/S transition of mitotic cell cycle (GO:0000082)2.97910931
135L-serine metabolic process (GO:0006563)2.97626154
136establishment of integrated proviral latency (GO:0075713)2.97468855
137respiratory chain complex IV assembly (GO:0008535)2.96415457
138protein insertion into membrane (GO:0051205)2.96248479
139regulation of ligase activity (GO:0051340)2.94811361
140aerobic respiration (GO:0009060)2.94366801
141transcription from RNA polymerase I promoter (GO:0006360)2.92731424
142tRNA modification (GO:0006400)2.90748876
143COPI coating of Golgi vesicle (GO:0048205)2.89832955
144Golgi transport vesicle coating (GO:0048200)2.89832955
145negative regulation of mRNA processing (GO:0050686)2.86581057
146pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85662303
147negative regulation of B cell apoptotic process (GO:0002903)2.84884012
148heterochromatin organization (GO:0070828)2.83343676
149pentose-phosphate shunt (GO:0006098)2.82875237
150CTP metabolic process (GO:0046036)2.81736135
151CTP biosynthetic process (GO:0006241)2.81736135
152regulation of translational elongation (GO:0006448)2.81657860
153GTP biosynthetic process (GO:0006183)2.77953987
154negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77682018
155base-excision repair (GO:0006284)2.75341190
156establishment of viral latency (GO:0019043)2.73347739
157pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72043459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.67383755
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21289160
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04992152
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96710995
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76564971
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.54685965
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.54377453
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.40972435
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22314988
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10183151
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09360013
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83760776
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71390248
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70671601
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44075206
16VDR_23849224_ChIP-Seq_CD4+_Human2.41152865
17XRN2_22483619_ChIP-Seq_HELA_Human2.37893343
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33870941
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32460319
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29141935
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26055181
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24646953
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.22632775
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20134925
25DCP1A_22483619_ChIP-Seq_HELA_Human2.16926888
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15321547
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14442984
28FOXP3_21729870_ChIP-Seq_TREG_Human2.13044979
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.10912139
30GABP_19822575_ChIP-Seq_HepG2_Human2.08333173
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03125666
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95655497
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95022000
34LXR_22292898_ChIP-Seq_THP-1_Human1.86577818
35* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83515041
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82083457
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80980193
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78637975
39TTF2_22483619_ChIP-Seq_HELA_Human1.77086740
40ZNF263_19887448_ChIP-Seq_K562_Human1.75508794
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74754854
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72135223
43CIITA_25753668_ChIP-Seq_RAJI_Human1.71950989
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.69175346
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67284183
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.63058301
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62653046
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59370951
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58406621
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.57967702
51* P68_20966046_ChIP-Seq_HELA_Human1.50683894
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50238166
53ELK1_19687146_ChIP-ChIP_HELA_Human1.50224307
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50147454
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47452757
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46810674
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45242419
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44213410
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44162692
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43269291
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41073190
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40211113
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39425937
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.39020193
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.35443277
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31984830
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29086481
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28144507
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.28017733
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22516096
71AR_21909140_ChIP-Seq_LNCAP_Human1.22184271
72KDM5A_27292631_Chip-Seq_BREAST_Human1.22013160
73* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21501400
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.21096567
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20590460
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19065819
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.18919464
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.18263278
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16781583
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.16623792
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16409936
82BCL6_27268052_Chip-Seq_Bcells_Human1.15541764
83BCOR_27268052_Chip-Seq_Bcells_Human1.14810863
84MYC_22102868_ChIP-Seq_BL_Human1.14434833
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13463669
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12557435
87* CTCF_26484167_Chip-Seq_Bcells_Mouse1.12132490
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11398329
89MAF_26560356_Chip-Seq_TH2_Human1.09177232
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09095807
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08652693
92* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08585569
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08576192
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08344129
95TFEB_21752829_ChIP-Seq_HELA_Human1.06956074
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06939154
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06465127
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03465491
99* PHF8_20622854_ChIP-Seq_HELA_Human1.03005976
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02851255
101SPI1_23547873_ChIP-Seq_NB4_Human1.01930161
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01694311
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01010736
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00032315
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99943858
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99456483
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98834965
108MAF_26560356_Chip-Seq_TH1_Human0.98286819
109* ATF3_27146783_Chip-Seq_COLON_Human0.97656029
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96924554
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95323453
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94807010
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94373680
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94340031
115CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93865523
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93396294
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93064914
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92185382
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92019948
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91786105
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89282445
122VDR_21846776_ChIP-Seq_THP-1_Human0.88779472
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88432915
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88158674
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88030969
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87778504
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87302050
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86643461
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86117491
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.85291584
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85025978
132FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84883916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79563329
2MP0004957_abnormal_blastocyst_morpholog3.71251695
3MP0003646_muscle_fatigue3.71101030
4MP0003111_abnormal_nucleus_morphology3.13200609
5MP0003806_abnormal_nucleotide_metabolis3.12032286
6MP0006036_abnormal_mitochondrial_physio2.98951388
7MP0010094_abnormal_chromosome_stability2.96959918
8MP0004084_abnormal_cardiac_muscle2.92675899
9MP0003077_abnormal_cell_cycle2.92177133
10MP0008058_abnormal_DNA_repair2.65276875
11MP0002837_dystrophic_cardiac_calcinosis2.61322282
12MP0002877_abnormal_melanocyte_morpholog2.41054805
13MP0003186_abnormal_redox_activity2.27317190
14MP0005058_abnormal_lysosome_morphology2.24415951
15MP0004233_abnormal_muscle_weight2.22079847
16MP0008932_abnormal_embryonic_tissue2.17290687
17MP0006035_abnormal_mitochondrial_morpho2.13638691
18MP0000678_abnormal_parathyroid_gland2.09722555
19MP0000749_muscle_degeneration2.05316611
20MP0002396_abnormal_hematopoietic_system2.03808545
21MP0005330_cardiomyopathy2.01343058
22MP0004215_abnormal_myocardial_fiber1.96510196
23MP0008007_abnormal_cellular_replicative1.95658527
24MP0005501_abnormal_skin_physiology1.92173625
25MP0009333_abnormal_splenocyte_physiolog1.89687608
26MP0003718_maternal_effect1.88178655
27MP0004185_abnormal_adipocyte_glucose1.88081540
28MP0002163_abnormal_gland_morphology1.87598599
29MP0008057_abnormal_DNA_replication1.86795048
30MP0003786_premature_aging1.85667544
31MP0004036_abnormal_muscle_relaxation1.82321557
32MP0000750_abnormal_muscle_regeneration1.69028077
33MP0001661_extended_life_span1.64959675
34MP0002796_impaired_skin_barrier1.63055773
35MP0003221_abnormal_cardiomyocyte_apopto1.61238707
36MP0004858_abnormal_nervous_system1.60350518
37MP0001730_embryonic_growth_arrest1.59555491
38MP0003763_abnormal_thymus_physiology1.57779631
39MP0009278_abnormal_bone_marrow1.57437939
40MP0001873_stomach_inflammation1.50850697
41MP0000003_abnormal_adipose_tissue1.49920973
42MP0002132_abnormal_respiratory_system1.46515472
43MP0002269_muscular_atrophy1.41892511
44MP0003705_abnormal_hypodermis_morpholog1.41092892
45MP0000490_abnormal_crypts_of1.40380161
46MP0003567_abnormal_fetal_cardiomyocyte1.40167355
47MP0000751_myopathy1.39738489
48MP0004147_increased_porphyrin_level1.39249093
49MP0005671_abnormal_response_to1.39096337
50MP0008877_abnormal_DNA_methylation1.36288411
51MP0000358_abnormal_cell_content/1.33471775
52MP0000313_abnormal_cell_death1.29399250
53MP0005385_cardiovascular_system_phenoty1.28992959
54MP0001544_abnormal_cardiovascular_syste1.28992959
55MP0001346_abnormal_lacrimal_gland1.26058134
56MP0003123_paternal_imprinting1.26039685
57MP0008775_abnormal_heart_ventricle1.24907597
58MP0002249_abnormal_larynx_morphology1.23824838
59MP0001881_abnormal_mammary_gland1.21712617
60MP0001764_abnormal_homeostasis1.21366104
61MP0002722_abnormal_immune_system1.20288757
62MP0009379_abnormal_foot_pigmentation1.17638169
63MP0005266_abnormal_metabolism1.17615275
64MP0002019_abnormal_tumor_incidence1.17470532
65MP0001853_heart_inflammation1.17442392
66MP0000350_abnormal_cell_proliferation1.17397892
67MP0005670_abnormal_white_adipose1.15821350
68MP0002080_prenatal_lethality1.14614833
69MP0000689_abnormal_spleen_morphology1.14483985
70MP0009785_altered_susceptibility_to1.14446956
71MP0002398_abnormal_bone_marrow1.14156844
72MP0005076_abnormal_cell_differentiation1.13096367
73MP0000343_altered_response_to1.12694216
74MP0001697_abnormal_embryo_size1.12444794
75MP0003984_embryonic_growth_retardation1.11839240
76MP0001835_abnormal_antigen_presentation1.11210707
77MP0008260_abnormal_autophagy1.11136812
78MP0005623_abnormal_meninges_morphology1.11031450
79MP0005397_hematopoietic_system_phenotyp1.09947990
80MP0001545_abnormal_hematopoietic_system1.09947990
81MP0001672_abnormal_embryogenesis/_devel1.08669145
82MP0005380_embryogenesis_phenotype1.08669145
83MP0002972_abnormal_cardiac_muscle1.07791219
84MP0000747_muscle_weakness1.07475488
85MP0001348_abnormal_lacrimal_gland1.07463157
86MP0002088_abnormal_embryonic_growth/wei1.06071352
87MP0002127_abnormal_cardiovascular_syste1.05310439
88MP0002106_abnormal_muscle_physiology1.03676177
89MP0003656_abnormal_erythrocyte_physiolo1.02382158
90MP0002429_abnormal_blood_cell1.01310988
91MP0001727_abnormal_embryo_implantation1.00881499
92MP0000703_abnormal_thymus_morphology1.00635439
93MP0002089_abnormal_postnatal_growth/wei1.00432448
94MP0005075_abnormal_melanosome_morpholog0.99279751
95MP0004808_abnormal_hematopoietic_stem0.99123466
96MP0000681_abnormal_thyroid_gland0.98461268
97MP0004087_abnormal_muscle_fiber0.97911480
98MP0005375_adipose_tissue_phenotype0.95507822
99MP0005451_abnormal_body_composition0.95505572
100MP0009840_abnormal_foam_cell0.94235672
101MP0009672_abnormal_birth_weight0.92913616
102MP0010030_abnormal_orbit_morphology0.92744114
103MP0010630_abnormal_cardiac_muscle0.92192693
104MP0003453_abnormal_keratinocyte_physiol0.90539540
105MP0006054_spinal_hemorrhage0.89794352
106MP0000716_abnormal_immune_system0.88816977
107MP0005666_abnormal_adipose_tissue0.88228253
108MP0006138_congestive_heart_failure0.87072606
109MP0003828_pulmonary_edema0.86936735
110MP0010307_abnormal_tumor_latency0.86867731
111MP0005319_abnormal_enzyme/_coenzyme0.86308289
112MP0000858_altered_metastatic_potential0.85979237
113MP0005084_abnormal_gallbladder_morpholo0.85960726
114MP0005083_abnormal_biliary_tract0.85805822
115MP0002970_abnormal_white_adipose0.85543293
116MP0009931_abnormal_skin_appearance0.85297509
117MP0000759_abnormal_skeletal_muscle0.85217961
118MP0003137_abnormal_impulse_conducting0.84226318
119MP0002085_abnormal_embryonic_tissue0.82113350
120MP0003724_increased_susceptibility_to0.78937223
121MP0005384_cellular_phenotype0.78437169
122MP0001849_ear_inflammation0.78300069
123MP0009643_abnormal_urine_homeostasis0.78040095
124MP0002420_abnormal_adaptive_immunity0.77249181
125MP0001216_abnormal_epidermal_layer0.76833674
126MP0001819_abnormal_immune_cell0.76728026
127MP0005332_abnormal_amino_acid0.76315715
128MP0003315_abnormal_perineum_morphology0.75655407
129MP0005620_abnormal_muscle_contractility0.75041355
130MP0005025_abnormal_response_to0.74625287
131MP0000685_abnormal_immune_system0.74121561
132MP0002210_abnormal_sex_determination0.73752117
133MP0002098_abnormal_vibrissa_morphology0.73221002
134MP0001800_abnormal_humoral_immune0.72276942
135MP0005369_muscle_phenotype0.71756828
136MP0005621_abnormal_cell_physiology0.71743426
137MP0002723_abnormal_immune_serum0.71128477
138MP0005636_abnormal_mineral_homeostasis0.71037223
139MP0010771_integument_phenotype0.70725081
140MP0002405_respiratory_system_inflammati0.70457310
141MP0002160_abnormal_reproductive_system0.68982581
142MP0002332_abnormal_exercise_endurance0.68856938
143MP0008995_early_reproductive_senescence0.67974917
144MP0000537_abnormal_urethra_morphology0.67801091
145MP0002086_abnormal_extraembryonic_tissu0.65695780
146MP0000733_abnormal_muscle_development0.64975644
147MP0000467_abnormal_esophagus_morphology0.64281413
148MP0009697_abnormal_copulation0.60530685
149MP0002060_abnormal_skin_morphology0.59919253
150MP0000609_abnormal_liver_physiology0.59587600

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.95708858
2Hepatic necrosis (HP:0002605)4.89388979
3Acute necrotizing encephalopathy (HP:0006965)4.71359936
4Abnormal mitochondria in muscle tissue (HP:0008316)4.63580795
5Mitochondrial inheritance (HP:0001427)4.62450655
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.45002432
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.45002432
8Increased CSF lactate (HP:0002490)4.37615065
9Abnormal number of erythroid precursors (HP:0012131)4.18536493
10Abnormality of cells of the erythroid lineage (HP:0012130)4.18065361
11Acute encephalopathy (HP:0006846)3.98140968
12Increased serum lactate (HP:0002151)3.73706816
13Cholecystitis (HP:0001082)3.62059888
14Abnormal gallbladder physiology (HP:0012438)3.62059888
15Lactic acidosis (HP:0003128)3.58358603
16Progressive macrocephaly (HP:0004481)3.52801590
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51211039
18Increased intramyocellular lipid droplets (HP:0012240)3.47427452
19Reticulocytopenia (HP:0001896)3.47002969
20Lipid accumulation in hepatocytes (HP:0006561)3.44207157
21Increased muscle lipid content (HP:0009058)3.44164080
22Abnormality of glycolysis (HP:0004366)3.37153074
23Increased serum pyruvate (HP:0003542)3.37153074
24Increased hepatocellular lipid droplets (HP:0006565)3.37046187
25Exercise intolerance (HP:0003546)3.31388067
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26382522
27Respiratory failure (HP:0002878)3.26131356
28Birth length less than 3rd percentile (HP:0003561)3.22934409
29Cerebral hypomyelination (HP:0006808)3.10859725
30Breast hypoplasia (HP:0003187)3.03568375
31Cerebral edema (HP:0002181)3.00932957
32Multiple enchondromatosis (HP:0005701)2.99547803
33Hyperacusis (HP:0010780)2.99429475
343-Methylglutaconic aciduria (HP:0003535)2.97014214
35Oral leukoplakia (HP:0002745)2.89702195
36Aplastic anemia (HP:0001915)2.89054671
37Type I transferrin isoform profile (HP:0003642)2.85932634
38Rhabdomyolysis (HP:0003201)2.80829676
39Exertional dyspnea (HP:0002875)2.77882899
40Rough bone trabeculation (HP:0100670)2.75895757
41CNS demyelination (HP:0007305)2.75708150
42Respiratory difficulties (HP:0002880)2.73631955
43Palpitations (HP:0001962)2.70042713
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68141718
45Abnormality of alanine metabolism (HP:0010916)2.68141718
46Hyperalaninemia (HP:0003348)2.68141718
47Macrocytic anemia (HP:0001972)2.67462377
48Achilles tendon contracture (HP:0001771)2.66989649
49Myopathic facies (HP:0002058)2.61345600
50Degeneration of anterior horn cells (HP:0002398)2.60453828
51Abnormality of the anterior horn cell (HP:0006802)2.60453828
52Ragged-red muscle fibers (HP:0003200)2.59978055
53Dicarboxylic aciduria (HP:0003215)2.59332532
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59332532
55Ventricular tachycardia (HP:0004756)2.56769910
56Broad distal phalanx of finger (HP:0009836)2.56006790
57Emotional lability (HP:0000712)2.49408259
58Generalized aminoaciduria (HP:0002909)2.48549773
59Nausea (HP:0002018)2.45556071
60Hypertensive crisis (HP:0100735)2.43247433
61Septate vagina (HP:0001153)2.40155217
62Renal Fanconi syndrome (HP:0001994)2.39544939
63Microretrognathia (HP:0000308)2.39432457
64Carpal bone hypoplasia (HP:0001498)2.35571157
65Lethargy (HP:0001254)2.32560342
66Truncus arteriosus (HP:0001660)2.30692173
67Abnormality of reticulocytes (HP:0004312)2.30409772
68Squamous cell carcinoma (HP:0002860)2.28161926
69Esophageal neoplasm (HP:0100751)2.26631122
70Neoplasm of head and neck (HP:0012288)2.26631122
71Pallor (HP:0000980)2.25995300
72Progressive muscle weakness (HP:0003323)2.24580063
73Abnormality of the Achilles tendon (HP:0005109)2.24058129
74Insomnia (HP:0100785)2.21830834
75Opisthotonus (HP:0002179)2.20550025
76Reticulocytosis (HP:0001923)2.19188044
77IgM deficiency (HP:0002850)2.17012464
78Hypokinesia (HP:0002375)2.14560067
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.14549204
80Unilateral renal agenesis (HP:0000122)2.14432475
81Abnormality of fatty-acid metabolism (HP:0004359)2.13793601
82Type 2 muscle fiber atrophy (HP:0003554)2.13759046
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13706089
84Microvesicular hepatic steatosis (HP:0001414)2.13442451
85Abnormal glycosylation (HP:0012345)2.12929573
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12929573
87Abnormal protein N-linked glycosylation (HP:0012347)2.12929573
88Abnormal protein glycosylation (HP:0012346)2.12929573
89Unsteady gait (HP:0002317)2.12869593
90Muscle fiber atrophy (HP:0100295)2.12002415
91Abnormality of the umbilical cord (HP:0010881)2.09841753
92Sudden death (HP:0001699)2.08746391
93Myoglobinuria (HP:0002913)2.08630814
94Cholelithiasis (HP:0001081)2.07731510
95Hyperthyroidism (HP:0000836)2.06842551
96Premature skin wrinkling (HP:0100678)2.04789080
97Premature ovarian failure (HP:0008209)2.03550066
98Lipoatrophy (HP:0100578)2.03303320
99Gastrointestinal stroma tumor (HP:0100723)2.01132818
100Secondary amenorrhea (HP:0000869)1.96414163
101Abnormal trabecular bone morphology (HP:0100671)1.95969203
102Neoplasm of the adrenal gland (HP:0100631)1.94944030
103Leukodystrophy (HP:0002415)1.94917166
104Thrombocytosis (HP:0001894)1.93308487
105Progressive microcephaly (HP:0000253)1.92964326
106Long palpebral fissure (HP:0000637)1.91672689
107Hypergonadotropic hypogonadism (HP:0000815)1.91337368
108Seborrheic dermatitis (HP:0001051)1.91003285
109Abnormality of the gallbladder (HP:0005264)1.90939092
110Fasciculations (HP:0002380)1.90627292
111Gliosis (HP:0002171)1.89927168
112Abnormality of urine glucose concentration (HP:0011016)1.89801111
113Glycosuria (HP:0003076)1.89801111
114Premature graying of hair (HP:0002216)1.89763648
115Pancytopenia (HP:0001876)1.87110449
116Reduced antithrombin III activity (HP:0001976)1.86710253
117Selective tooth agenesis (HP:0001592)1.86654199
118Distal lower limb muscle weakness (HP:0009053)1.86501149
119Trismus (HP:0000211)1.86125519
120Areflexia of lower limbs (HP:0002522)1.85858307
121Hyperglycinuria (HP:0003108)1.85023727
122Nonimmune hydrops fetalis (HP:0001790)1.84958942
123Neuroendocrine neoplasm (HP:0100634)1.83732892
124Dilated cardiomyopathy (HP:0001644)1.83109127
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.82070225
126Patellar aplasia (HP:0006443)1.80974271
127Methylmalonic aciduria (HP:0012120)1.80817204
128Horseshoe kidney (HP:0000085)1.79903623
129Abnormal umbilical cord blood vessels (HP:0011403)1.79557048
130Single umbilical artery (HP:0001195)1.79557048
131Abnormality of the fetal cardiovascular system (HP:0010948)1.79557048
132Self-mutilation (HP:0000742)1.79354380
133Tinnitus (HP:0000360)1.77316614
134Proximal tubulopathy (HP:0000114)1.77167837
135Poor head control (HP:0002421)1.76507533
136Sparse eyelashes (HP:0000653)1.76460150
137Optic disc pallor (HP:0000543)1.76356499
138Spastic paraparesis (HP:0002313)1.76323889
139Deep palmar crease (HP:0006191)1.76303037
140Vertebral compression fractures (HP:0002953)1.75716037
141Testicular atrophy (HP:0000029)1.75513528
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74915754
143Generalized amyotrophy (HP:0003700)1.73648649
144Stridor (HP:0010307)1.72717024
145Increased serum ferritin (HP:0003281)1.71155725
146Abnormality of subcutaneous fat tissue (HP:0001001)1.69932576
147Redundant skin (HP:0001582)1.69197352
148Prolonged neonatal jaundice (HP:0006579)1.68353965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.16025177
2STK163.89398503
3SMG13.76469693
4NME23.65091889
5VRK23.47721784
6TRIB33.43923307
7WEE13.39617981
8EIF2AK13.17224180
9BCKDK2.95444241
10EEF2K2.76197713
11KDR2.47479734
12TESK22.40928576
13PIM22.35316811
14TSSK62.34482025
15NEK12.27599159
16ICK2.06643652
17PLK42.04159883
18MYLK1.98707154
19EIF2AK31.69757498
20CDC71.68379851
21VRK11.64788838
22PRPF4B1.63818394
23SIK11.63489864
24BRSK21.62304866
25SRPK11.62091170
26MAP3K111.61716640
27MAP4K11.61044409
28ARAF1.56299090
29ZAK1.54475537
30NME11.49573071
31CDK121.44351763
32BRAF1.35325640
33ACVR1B1.34172516
34TLK11.31672688
35PDK31.29310146
36PDK41.29310146
37NEK21.25626952
38OBSCN1.19771355
39PLK11.19261587
40PDK21.16274287
41RPS6KA41.15594419
42MAP3K121.12877530
43TESK11.12086378
44BRSK11.11924694
45AURKB1.08505098
46TTK1.07667247
47MAPK111.06687251
48TGFBR11.06150309
49CCNB11.04148292
50PRKD31.02028923
51AURKA0.95179413
52MAPKAPK30.94838378
53MUSK0.93680800
54TAF10.93272853
55IRAK40.93204636
56CDK70.92566408
57ILK0.92026782
58PBK0.90395023
59TIE10.89685504
60DYRK30.88454386
61FLT30.86208355
62AKT30.85911920
63ZAP700.85391772
64PAK40.85385966
65RPS6KB20.85383879
66EPHA20.82961509
67CDK190.81509098
68LRRK20.79498097
69STK240.79135523
70IRAK30.76683253
71MAP3K100.75753482
72ATR0.75011862
73AKT20.73902984
74MAP3K130.73771312
75DAPK30.73299154
76TAOK20.72511615
77MAP2K20.71271813
78STK40.70105715
79PIM10.68558545
80PLK30.67747449
81LIMK10.65593986
82MAP3K80.65540527
83TBK10.63535991
84PAK10.62532598
85CSNK2A10.61789545
86CDK80.61690954
87MAP2K30.61406055
88CSNK1G30.60669542
89TXK0.60507603
90PASK0.60132712
91STK38L0.58727016
92SIK20.58629849
93PINK10.57948236
94TEC0.57594665
95MAP3K90.57393026
96DAPK10.57265842
97PRKCI0.56244207
98ABL20.56226790
99CDK40.55843513
100TTN0.55801778
101BLK0.54339757
102KIT0.54062216
103IRAK20.52993572
104CSNK2A20.52032316
105MTOR0.51928692
106CDK90.51050094
107MKNK10.48303859
108CHEK20.48029281
109MST1R0.47837198
110STK100.47576528
111TYK20.47406932
112LMTK20.47211339
113RAF10.46918404
114MAP2K60.46452761
115PDPK10.46150173
116SCYL20.45724603
117ERN10.45105253
118MAP3K30.43774935
119MAP3K10.42737350
120CDK20.42551639
121MAPKAPK50.42533203
122BTK0.42461880
123MAPKAPK20.42443830
124PKN20.41639788
125IKBKB0.39439781
126HIPK20.38511811
127PRKD20.37785072
128SYK0.37037081
129BMX0.36479587
130ALK0.36132452
131CDK11A0.35866338
132RPS6KA50.34937940
133EIF2AK20.34561096
134MST40.34118234
135CHEK10.33997565
136MOS0.33558809
137CDK10.32199716

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47774673
2* Ribosome_Homo sapiens_hsa030104.05942634
3DNA replication_Homo sapiens_hsa030303.81760591
4RNA polymerase_Homo sapiens_hsa030203.70541042
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29498825
6Oxidative phosphorylation_Homo sapiens_hsa001903.06821431
7Mismatch repair_Homo sapiens_hsa034303.03724470
8Parkinsons disease_Homo sapiens_hsa050122.88608789
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77922211
10Pyrimidine metabolism_Homo sapiens_hsa002402.59367369
11Base excision repair_Homo sapiens_hsa034102.42744426
12Spliceosome_Homo sapiens_hsa030402.40526758
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32159509
14Huntingtons disease_Homo sapiens_hsa050162.17159187
15Homologous recombination_Homo sapiens_hsa034402.14662792
16Nucleotide excision repair_Homo sapiens_hsa034202.07053837
17RNA transport_Homo sapiens_hsa030132.02836790
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76254674
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73065124
20Alzheimers disease_Homo sapiens_hsa050101.72426305
21Carbon metabolism_Homo sapiens_hsa012001.62749795
22Protein export_Homo sapiens_hsa030601.59899128
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58003422
24Purine metabolism_Homo sapiens_hsa002301.48524155
25RNA degradation_Homo sapiens_hsa030181.44910798
26Cell cycle_Homo sapiens_hsa041101.38988286
27Folate biosynthesis_Homo sapiens_hsa007901.36172642
28Cardiac muscle contraction_Homo sapiens_hsa042601.35485930
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34400154
30One carbon pool by folate_Homo sapiens_hsa006701.30782603
31Biosynthesis of amino acids_Homo sapiens_hsa012301.30659382
32Basal transcription factors_Homo sapiens_hsa030221.29609928
33Pentose phosphate pathway_Homo sapiens_hsa000301.28374859
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24119359
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.21208547
36Fanconi anemia pathway_Homo sapiens_hsa034601.17293559
37Vitamin B6 metabolism_Homo sapiens_hsa007501.15502131
38Pyruvate metabolism_Homo sapiens_hsa006201.12365633
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08488856
40Bladder cancer_Homo sapiens_hsa052191.08191496
41Fructose and mannose metabolism_Homo sapiens_hsa000511.04900016
42Non-homologous end-joining_Homo sapiens_hsa034501.03721900
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.03682598
44Sulfur relay system_Homo sapiens_hsa041221.02356199
45Epstein-Barr virus infection_Homo sapiens_hsa051690.95390920
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.94202435
47Propanoate metabolism_Homo sapiens_hsa006400.93254662
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.87104490
49p53 signaling pathway_Homo sapiens_hsa041150.86704488
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85759851
51Primary immunodeficiency_Homo sapiens_hsa053400.85489788
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78944900
53Glutathione metabolism_Homo sapiens_hsa004800.77168100
54Acute myeloid leukemia_Homo sapiens_hsa052210.75530208
55Galactose metabolism_Homo sapiens_hsa000520.72411593
56Metabolic pathways_Homo sapiens_hsa011000.71548132
57Regulation of autophagy_Homo sapiens_hsa041400.67921786
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66264855
59Antigen processing and presentation_Homo sapiens_hsa046120.65902263
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65321033
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62538275
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62434633
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61477094
64Selenocompound metabolism_Homo sapiens_hsa004500.61165229
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60953024
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57609679
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55073846
68Chronic myeloid leukemia_Homo sapiens_hsa052200.53469297
69Legionellosis_Homo sapiens_hsa051340.53251459
70Fatty acid degradation_Homo sapiens_hsa000710.53085107
71Fatty acid elongation_Homo sapiens_hsa000620.52000106
72Prion diseases_Homo sapiens_hsa050200.51216692
73Herpes simplex infection_Homo sapiens_hsa051680.49507296
74mRNA surveillance pathway_Homo sapiens_hsa030150.49019563
75Alcoholism_Homo sapiens_hsa050340.48254088
76Arginine and proline metabolism_Homo sapiens_hsa003300.46708845
77Arginine biosynthesis_Homo sapiens_hsa002200.45594967
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45587259
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43252253
80Other glycan degradation_Homo sapiens_hsa005110.42554719
81Non-small cell lung cancer_Homo sapiens_hsa052230.41783053
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41558528
83VEGF signaling pathway_Homo sapiens_hsa043700.41028585
84Peroxisome_Homo sapiens_hsa041460.40510303
85Tyrosine metabolism_Homo sapiens_hsa003500.34516495
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.32910043
87Arachidonic acid metabolism_Homo sapiens_hsa005900.32250487
88B cell receptor signaling pathway_Homo sapiens_hsa046620.30931416
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30278515
90Lysine degradation_Homo sapiens_hsa003100.26747514
91Collecting duct acid secretion_Homo sapiens_hsa049660.24211322
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.23946490
93AMPK signaling pathway_Homo sapiens_hsa041520.23280363
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22365033
95HTLV-I infection_Homo sapiens_hsa051660.22300066
96Fatty acid metabolism_Homo sapiens_hsa012120.22075142
97beta-Alanine metabolism_Homo sapiens_hsa004100.21059984
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21020192
99Pancreatic cancer_Homo sapiens_hsa052120.20478428
100Measles_Homo sapiens_hsa051620.19618270
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19373863
102Sulfur metabolism_Homo sapiens_hsa009200.19119864
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19095566
104N-Glycan biosynthesis_Homo sapiens_hsa005100.18969253
105Steroid biosynthesis_Homo sapiens_hsa001000.18965871
106Viral carcinogenesis_Homo sapiens_hsa052030.18399744
107Thyroid cancer_Homo sapiens_hsa052160.18219273
108Insulin signaling pathway_Homo sapiens_hsa049100.18160492
109Oocyte meiosis_Homo sapiens_hsa041140.17516749
110Lysosome_Homo sapiens_hsa041420.17425876
111Viral myocarditis_Homo sapiens_hsa054160.16992875
112Vibrio cholerae infection_Homo sapiens_hsa051100.16958626
113Shigellosis_Homo sapiens_hsa051310.15603477
114HIF-1 signaling pathway_Homo sapiens_hsa040660.15387648
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.15152592
116Apoptosis_Homo sapiens_hsa042100.14687576
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14278943
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13094467
119Systemic lupus erythematosus_Homo sapiens_hsa053220.08420461
120Allograft rejection_Homo sapiens_hsa053300.08185360
121Hematopoietic cell lineage_Homo sapiens_hsa046400.08109624
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04207933
123Phenylalanine metabolism_Homo sapiens_hsa003600.03447735
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03237529
125Renin-angiotensin system_Homo sapiens_hsa046140.03017087
126Dilated cardiomyopathy_Homo sapiens_hsa054140.01584672

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