MRPL40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.59440747
2respiratory electron transport chain (GO:0022904)5.25733316
3DNA deamination (GO:0045006)5.17166085
4electron transport chain (GO:0022900)5.15353125
5protein complex biogenesis (GO:0070271)5.06764177
6proteasome assembly (GO:0043248)4.97793197
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.86496713
8NADH dehydrogenase complex assembly (GO:0010257)4.86496713
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.86496713
10ribosomal small subunit assembly (GO:0000028)4.83422510
11mitochondrial respiratory chain complex assembly (GO:0033108)4.79605182
12maturation of SSU-rRNA (GO:0030490)4.75940077
13telomere maintenance via semi-conservative replication (GO:0032201)4.50240814
14rRNA modification (GO:0000154)4.46077202
15ribosomal small subunit biogenesis (GO:0042274)4.45154339
16DNA strand elongation involved in DNA replication (GO:0006271)4.42309543
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.42123236
18termination of RNA polymerase III transcription (GO:0006386)4.42123236
19chaperone-mediated protein transport (GO:0072321)4.40365080
20DNA replication checkpoint (GO:0000076)4.39717392
21ribosomal large subunit biogenesis (GO:0042273)4.38673891
22viral transcription (GO:0019083)4.28497559
23respiratory chain complex IV assembly (GO:0008535)4.26074132
24nucleobase biosynthetic process (GO:0046112)4.25306852
25purine nucleobase biosynthetic process (GO:0009113)4.25120829
26translational termination (GO:0006415)4.24231458
27DNA replication initiation (GO:0006270)4.23327742
28DNA strand elongation (GO:0022616)4.21101346
29ribonucleoprotein complex biogenesis (GO:0022613)4.13951387
30formation of translation preinitiation complex (GO:0001731)4.13641858
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11435747
32telomere maintenance via recombination (GO:0000722)4.05361278
33mitotic metaphase plate congression (GO:0007080)4.02038697
34CENP-A containing nucleosome assembly (GO:0034080)4.00216532
35cytochrome complex assembly (GO:0017004)4.00022230
36ribosome biogenesis (GO:0042254)3.99359338
37oxidative phosphorylation (GO:0006119)3.96454977
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.93269838
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92653705
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92228646
41chromatin remodeling at centromere (GO:0031055)3.89704115
42protein targeting to mitochondrion (GO:0006626)3.88041571
437-methylguanosine mRNA capping (GO:0006370)3.82672827
44translational elongation (GO:0006414)3.80295472
45GTP biosynthetic process (GO:0006183)3.80085326
46spliceosomal snRNP assembly (GO:0000387)3.78480540
47translational initiation (GO:0006413)3.78115753
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76669721
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.76546415
50RNA capping (GO:0036260)3.75762674
517-methylguanosine RNA capping (GO:0009452)3.75762674
52rRNA processing (GO:0006364)3.75525518
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75021827
54negative regulation of ligase activity (GO:0051352)3.75021827
55pseudouridine synthesis (GO:0001522)3.73691265
56mitotic recombination (GO:0006312)3.71144205
57cotranslational protein targeting to membrane (GO:0006613)3.71105054
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.70418280
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68527454
60ribosome assembly (GO:0042255)3.68347013
61ATP biosynthetic process (GO:0006754)3.67365528
62protein targeting to ER (GO:0045047)3.67130569
63establishment of protein localization to mitochondrion (GO:0072655)3.65032114
64rRNA metabolic process (GO:0016072)3.62916692
65transcription-coupled nucleotide-excision repair (GO:0006283)3.62633081
66translation (GO:0006412)3.62116514
67telomere maintenance via telomere lengthening (GO:0010833)3.60466693
68rRNA methylation (GO:0031167)3.60310168
69termination of RNA polymerase I transcription (GO:0006363)3.59000208
70protein neddylation (GO:0045116)3.58900442
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.58156385
72protein localization to mitochondrion (GO:0070585)3.55494406
73regulation of cellular amino acid metabolic process (GO:0006521)3.54547874
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54292486
75inner mitochondrial membrane organization (GO:0007007)3.53990566
76cellular component biogenesis (GO:0044085)3.52548578
77transcription from RNA polymerase I promoter (GO:0006360)3.52487244
78protein localization to endoplasmic reticulum (GO:0070972)3.52404438
79regulation of mitochondrial translation (GO:0070129)3.49349342
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49275074
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49275074
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49275074
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48863475
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48863475
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.48653211
86establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48075258
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46449922
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46449922
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45483442
90DNA replication-independent nucleosome assembly (GO:0006336)3.45109964
91DNA replication-independent nucleosome organization (GO:0034724)3.45109964
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44439045
93establishment of protein localization to mitochondrial membrane (GO:0090151)3.42826599
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42675372
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.42675372
96hydrogen ion transmembrane transport (GO:1902600)3.40648913
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40490410
98metaphase plate congression (GO:0051310)3.39477671
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39362324
100cellular protein complex disassembly (GO:0043624)3.38562738
101ribonucleoside triphosphate biosynthetic process (GO:0009201)3.38040674
102signal transduction involved in cell cycle checkpoint (GO:0072395)3.37526837
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36450434
104cullin deneddylation (GO:0010388)3.36305658
105guanosine-containing compound biosynthetic process (GO:1901070)3.35692196
106pteridine-containing compound biosynthetic process (GO:0042559)3.35680959
107kinetochore assembly (GO:0051382)3.35343321
108viral life cycle (GO:0019058)3.33517738
109peptidyl-histidine modification (GO:0018202)3.32877627
110UTP biosynthetic process (GO:0006228)3.32799355
111positive regulation of ligase activity (GO:0051351)3.32755996
112protein deneddylation (GO:0000338)3.29543508
113spliceosomal complex assembly (GO:0000245)3.26958106
114cell cycle G1/S phase transition (GO:0044843)3.26368524
115G1/S transition of mitotic cell cycle (GO:0000082)3.26368524
116mitochondrial transport (GO:0006839)3.25062345
117kinetochore organization (GO:0051383)3.24187773
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20055010
119establishment of integrated proviral latency (GO:0075713)3.19943971
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19152660
121histone exchange (GO:0043486)3.18026919
122nucleoside triphosphate biosynthetic process (GO:0009142)3.14213392
123water-soluble vitamin biosynthetic process (GO:0042364)3.13840894
124ATP synthesis coupled proton transport (GO:0015986)3.12987162
125energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12987162
126UTP metabolic process (GO:0046051)3.12141559
127maturation of 5.8S rRNA (GO:0000460)3.11133941
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10662232
129regulation of ubiquitin-protein transferase activity (GO:0051438)3.09913468
130transcription initiation from RNA polymerase I promoter (GO:0006361)3.09233999
131deoxyribonucleotide biosynthetic process (GO:0009263)3.08764637
132DNA replication-dependent nucleosome organization (GO:0034723)3.07992142
133DNA replication-dependent nucleosome assembly (GO:0006335)3.07992142
134proton transport (GO:0015992)3.07765425
135CTP metabolic process (GO:0046036)3.06177644
136CTP biosynthetic process (GO:0006241)3.06177644
137ubiquinone biosynthetic process (GO:0006744)3.05344260
138protein-cofactor linkage (GO:0018065)3.04392495
139purine nucleoside monophosphate biosynthetic process (GO:0009127)3.03622763
140purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.03622763
141hydrogen transport (GO:0006818)3.01563778
142aldehyde catabolic process (GO:0046185)3.01277284
143regulation of ligase activity (GO:0051340)2.96188552
144aerobic respiration (GO:0009060)2.92564629
145intracellular protein transmembrane import (GO:0044743)2.89853078
146pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.86990406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50102319
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43258940
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.39303320
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.89523337
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77735510
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.73819503
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64674343
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53227670
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.48396579
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29916157
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23075209
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11661141
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00287918
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92807991
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90114006
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84173131
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.76955038
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76739952
19* VDR_23849224_ChIP-Seq_CD4+_Human2.63297055
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62604691
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56337547
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.54204571
23XRN2_22483619_ChIP-Seq_HELA_Human2.43220538
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41838961
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37291753
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32709109
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30053909
28* DCP1A_22483619_ChIP-Seq_HELA_Human2.28239719
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.18929705
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11282520
31GABP_19822575_ChIP-Seq_HepG2_Human2.06475828
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06291623
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.04814841
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.01562350
35TTF2_22483619_ChIP-Seq_HELA_Human1.94860905
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93310583
37ELK1_19687146_ChIP-ChIP_HELA_Human1.88217118
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85391807
39AR_21909140_ChIP-Seq_LNCAP_Human1.80712236
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80239550
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79688716
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76410779
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75574659
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71363548
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70362394
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68031263
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65445345
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63751706
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58801091
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56987023
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.53846895
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45526240
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43792262
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39276156
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38341842
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33139931
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32358534
58KDM5A_27292631_Chip-Seq_BREAST_Human1.31342856
59CIITA_25753668_ChIP-Seq_RAJI_Human1.28480308
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.27551897
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24765143
62MYC_18940864_ChIP-ChIP_HL60_Human1.23060757
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22618905
64VDR_22108803_ChIP-Seq_LS180_Human1.19933456
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19301691
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15019015
67* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14212085
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13385966
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.12708038
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12549904
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11085538
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09634967
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08419579
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05835877
75ZNF274_21170338_ChIP-Seq_K562_Hela1.04505996
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04230590
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02430866
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97768969
79* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96742612
80TP53_22573176_ChIP-Seq_HFKS_Human0.96605473
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96605320
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92770458
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92317616
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91084280
85IRF1_19129219_ChIP-ChIP_H3396_Human0.90100064
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89646309
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89449721
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89437887
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88703577
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87553872
91TFEB_21752829_ChIP-Seq_HELA_Human0.85103314
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85004137
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.84918757
94HTT_18923047_ChIP-ChIP_STHdh_Human0.84906962
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84645230
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83673185
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.82360808
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81870395
99SPI1_23547873_ChIP-Seq_NB4_Human0.81735092
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81162903
101ZNF263_19887448_ChIP-Seq_K562_Human0.80842710
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80389892
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80044131
104* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79138683
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79019814
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78749397
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78490218
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78367252
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77770150
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77668001
111EWS_26573619_Chip-Seq_HEK293_Human0.75858325
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75824561
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75183318
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73261790
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71657726
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71466882
117ERG_20517297_ChIP-Seq_VCAP_Human0.71179147
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71081970
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70492959
120AR_20517297_ChIP-Seq_VCAP_Human0.69591117
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66842134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.35344804
2MP0004957_abnormal_blastocyst_morpholog4.72249174
3MP0010094_abnormal_chromosome_stability4.49528991
4MP0003111_abnormal_nucleus_morphology4.34636154
5MP0008057_abnormal_DNA_replication4.12230223
6MP0003077_abnormal_cell_cycle3.98437656
7MP0008058_abnormal_DNA_repair3.92125802
8MP0003718_maternal_effect3.04527670
9MP0008932_abnormal_embryonic_tissue3.02135652
10MP0003806_abnormal_nucleotide_metabolis2.99102012
11MP0002837_dystrophic_cardiac_calcinosis2.75688440
12MP0008007_abnormal_cellular_replicative2.59861956
13MP0003786_premature_aging2.46772890
14MP0003195_calcinosis2.35061735
15MP0008995_early_reproductive_senescence2.30869819
16MP0008875_abnormal_xenobiotic_pharmacok2.20974594
17MP0003186_abnormal_redox_activity2.14371155
18MP0003123_paternal_imprinting2.13074338
19MP0008877_abnormal_DNA_methylation2.11579930
20MP0002396_abnormal_hematopoietic_system2.04694403
21MP0005332_abnormal_amino_acid1.97424715
22MP0005084_abnormal_gallbladder_morpholo1.93739859
23MP0001730_embryonic_growth_arrest1.89345246
24MP0002139_abnormal_hepatobiliary_system1.85321288
25MP0005646_abnormal_pituitary_gland1.83658408
26MP0006072_abnormal_retinal_apoptosis1.78596459
27MP0009379_abnormal_foot_pigmentation1.75307504
28MP0006036_abnormal_mitochondrial_physio1.75177423
29MP0000350_abnormal_cell_proliferation1.74679718
30MP0003011_delayed_dark_adaptation1.71772185
31MP0000490_abnormal_crypts_of1.71549620
32MP0006292_abnormal_olfactory_placode1.71140796
33MP0005379_endocrine/exocrine_gland_phen1.67254651
34MP0004145_abnormal_muscle_electrophysio1.66514467
35MP0003315_abnormal_perineum_morphology1.65702532
36MP0005645_abnormal_hypothalamus_physiol1.61784608
37MP0009333_abnormal_splenocyte_physiolog1.61273658
38MP0002132_abnormal_respiratory_system1.54919320
39MP0003136_yellow_coat_color1.53184655
40MP0008260_abnormal_autophagy1.44081654
41MP0006035_abnormal_mitochondrial_morpho1.39352680
42MP0002210_abnormal_sex_determination1.36900266
43MP0000313_abnormal_cell_death1.33237246
44MP0001529_abnormal_vocalization1.32972124
45MP0005636_abnormal_mineral_homeostasis1.32695543
46MP0001697_abnormal_embryo_size1.32645089
47MP0005253_abnormal_eye_physiology1.30593869
48MP0002876_abnormal_thyroid_physiology1.29939971
49MP0000749_muscle_degeneration1.28305621
50MP0005075_abnormal_melanosome_morpholog1.27638648
51MP0001672_abnormal_embryogenesis/_devel1.26749087
52MP0005380_embryogenesis_phenotype1.26749087
53MP0004142_abnormal_muscle_tone1.26517744
54MP0002080_prenatal_lethality1.24798601
55MP0004043_abnormal_pH_regulation1.24267340
56MP0002019_abnormal_tumor_incidence1.22800170
57MP0009046_muscle_twitch1.22297631
58MP0002160_abnormal_reproductive_system1.21313349
59MP0001145_abnormal_male_reproductive1.16768079
60MP0005670_abnormal_white_adipose1.14317564
61MP0005551_abnormal_eye_electrophysiolog1.14263619
62MP0002102_abnormal_ear_morphology1.13148020
63MP0005083_abnormal_biliary_tract1.11440306
64MP0005365_abnormal_bile_salt1.11431000
65MP0003567_abnormal_fetal_cardiomyocyte1.11041151
66MP0001929_abnormal_gametogenesis1.10498252
67MP0001764_abnormal_homeostasis1.06719036
68MP0004019_abnormal_vitamin_homeostasis1.05885277
69MP0004381_abnormal_hair_follicle1.04741005
70MP0003984_embryonic_growth_retardation1.03945307
71MP0005451_abnormal_body_composition1.02907845
72MP0000516_abnormal_urinary_system1.02571967
73MP0005367_renal/urinary_system_phenotyp1.02571967
74MP0005410_abnormal_fertilization1.02077592
75MP0002085_abnormal_embryonic_tissue1.01467828
76MP0008872_abnormal_physiological_respon1.01071716
77MP0000653_abnormal_sex_gland1.01066148
78MP0005330_cardiomyopathy1.00341114
79MP0002163_abnormal_gland_morphology0.99901405
80MP0002088_abnormal_embryonic_growth/wei0.99877865
81MP0000358_abnormal_cell_content/0.99051612
82MP0001944_abnormal_pancreas_morphology0.98221608
83MP0003763_abnormal_thymus_physiology0.96627448
84MP0003646_muscle_fatigue0.96559660
85MP0005389_reproductive_system_phenotype0.96201959
86MP0004147_increased_porphyrin_level0.94060171
87MP0002638_abnormal_pupillary_reflex0.93738848
88MP0005220_abnormal_exocrine_pancreas0.92185261
89MP0003878_abnormal_ear_physiology0.89959025
90MP0005377_hearing/vestibular/ear_phenot0.89959025
91MP0003941_abnormal_skin_development0.89722087
92MP0002234_abnormal_pharynx_morphology0.88540895
93MP0005319_abnormal_enzyme/_coenzyme0.86399755
94MP0001119_abnormal_female_reproductive0.86373312
95MP0000631_abnormal_neuroendocrine_gland0.85956857
96MP0005085_abnormal_gallbladder_physiolo0.85501128
97MP0005395_other_phenotype0.85115905
98MP0005266_abnormal_metabolism0.85066367
99MP0003221_abnormal_cardiomyocyte_apopto0.84254670
100MP0002722_abnormal_immune_system0.83117862
101MP0004215_abnormal_myocardial_fiber0.83019580
102MP0002938_white_spotting0.82636220
103MP0008775_abnormal_heart_ventricle0.82286823
104MP0005397_hematopoietic_system_phenotyp0.81694116
105MP0001545_abnormal_hematopoietic_system0.81694116
106MP0000372_irregular_coat_pigmentation0.81455919
107MP0000689_abnormal_spleen_morphology0.81366455
108MP0000013_abnormal_adipose_tissue0.81079829
109MP0001853_heart_inflammation0.79508177
110MP0002398_abnormal_bone_marrow0.79223074
111MP0002736_abnormal_nociception_after0.78439533
112MP0002090_abnormal_vision0.78431544
113MP0004133_heterotaxia0.77902260
114MP0001756_abnormal_urination0.77328947
115MP0000566_synostosis0.77112645
116MP0002693_abnormal_pancreas_physiology0.77046843
117MP0000647_abnormal_sebaceous_gland0.76756035
118MP0002095_abnormal_skin_pigmentation0.75472946
119MP0000703_abnormal_thymus_morphology0.75254353
120MP0001905_abnormal_dopamine_level0.75063526
121MP0002086_abnormal_extraembryonic_tissu0.75045649
122MP0001984_abnormal_olfaction0.73896574
123MP0005408_hypopigmentation0.73852419
124MP0009697_abnormal_copulation0.73265489
125MP0005671_abnormal_response_to0.72689180
126MP0002277_abnormal_respiratory_mucosa0.72402153
127MP0009643_abnormal_urine_homeostasis0.71472980
128MP0002084_abnormal_developmental_patter0.71249662
129MP0002429_abnormal_blood_cell0.70992404
130MP0001986_abnormal_taste_sensitivity0.70625884
131MP0010307_abnormal_tumor_latency0.69882094
132MP0001293_anophthalmia0.69881993
133MP0003137_abnormal_impulse_conducting0.69731262
134MP0003656_abnormal_erythrocyte_physiolo0.69119750
135MP0001919_abnormal_reproductive_system0.69065925
136MP0010030_abnormal_orbit_morphology0.68735967
137MP0001485_abnormal_pinna_reflex0.66406458
138MP0006276_abnormal_autonomic_nervous0.65415623
139MP0005584_abnormal_enzyme/coenzyme_acti0.63908175
140MP0003121_genomic_imprinting0.63319704
141MP0001727_abnormal_embryo_implantation0.63126412
142MP0002653_abnormal_ependyma_morphology0.61755965
143MP0001661_extended_life_span0.59484701
144MP0003938_abnormal_ear_development0.58452753
145MP0000716_abnormal_immune_system0.58131183
146MP0004197_abnormal_fetal_growth/weight/0.56328568
147MP0005384_cellular_phenotype0.56307403
148MP0003698_abnormal_male_reproductive0.55109636
149MP0008789_abnormal_olfactory_epithelium0.55050176
150MP0002127_abnormal_cardiovascular_syste0.52664692

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.27577388
2Abnormality of cells of the erythroid lineage (HP:0012130)4.65273250
3Reticulocytopenia (HP:0001896)4.42945796
4Abnormal number of erythroid precursors (HP:0012131)4.42601910
5Breast hypoplasia (HP:0003187)4.21631993
6Cerebral hypomyelination (HP:0006808)3.77114125
7Acute necrotizing encephalopathy (HP:0006965)3.75334003
8Mitochondrial inheritance (HP:0001427)3.58966035
93-Methylglutaconic aciduria (HP:0003535)3.53394766
10Macrocytic anemia (HP:0001972)3.51160500
11Oral leukoplakia (HP:0002745)3.48603567
12Hepatocellular necrosis (HP:0001404)3.43808986
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.42854718
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.42854718
15Increased CSF lactate (HP:0002490)3.42565245
16Abnormal mitochondria in muscle tissue (HP:0008316)3.40913691
17Carpal bone hypoplasia (HP:0001498)3.38509845
18Increased serum lactate (HP:0002151)3.29595026
19Rough bone trabeculation (HP:0100670)3.29307009
20Increased hepatocellular lipid droplets (HP:0006565)3.22448410
21Hepatic necrosis (HP:0002605)3.20900944
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18360875
23Chromsome breakage (HP:0040012)3.09790926
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.08701397
25Acute encephalopathy (HP:0006846)3.06325156
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01655478
27Patellar aplasia (HP:0006443)3.01384185
28Aplastic anemia (HP:0001915)3.00866501
29Pallor (HP:0000980)2.99118794
30Abnormality of the preputium (HP:0100587)2.91593307
31Lipid accumulation in hepatocytes (HP:0006561)2.91376365
32Progressive macrocephaly (HP:0004481)2.90214056
33Generalized aminoaciduria (HP:0002909)2.88193245
34Aplasia/Hypoplasia of the patella (HP:0006498)2.86762832
35Increased serum pyruvate (HP:0003542)2.81134335
36Abnormality of glycolysis (HP:0004366)2.81134335
37Microretrognathia (HP:0000308)2.77852362
38Meckel diverticulum (HP:0002245)2.74785285
39Lethargy (HP:0001254)2.74573537
40Degeneration of anterior horn cells (HP:0002398)2.72932631
41Abnormality of the anterior horn cell (HP:0006802)2.72932631
42Optic disc pallor (HP:0000543)2.72581100
43Exertional dyspnea (HP:0002875)2.65848048
44Multiple enchondromatosis (HP:0005701)2.61791419
45Type I transferrin isoform profile (HP:0003642)2.61111811
46Abnormality of urine glucose concentration (HP:0011016)2.60998661
47Glycosuria (HP:0003076)2.60998661
48Leukodystrophy (HP:0002415)2.60031511
49Abnormality of the ileum (HP:0001549)2.58029298
50Abnormal trabecular bone morphology (HP:0100671)2.57483351
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57186707
52Microvesicular hepatic steatosis (HP:0001414)2.51474862
53Premature graying of hair (HP:0002216)2.51212851
54Methylmalonic acidemia (HP:0002912)2.51149083
55Lactic acidosis (HP:0003128)2.50932300
56Absent radius (HP:0003974)2.49444799
57Abnormality of renal resorption (HP:0011038)2.48783311
58Exercise intolerance (HP:0003546)2.47513152
59Impulsivity (HP:0100710)2.42792662
60Renal Fanconi syndrome (HP:0001994)2.42008870
61Absent thumb (HP:0009777)2.41912320
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41065689
63Abnormal protein N-linked glycosylation (HP:0012347)2.41065689
64Abnormal protein glycosylation (HP:0012346)2.41065689
65Abnormal glycosylation (HP:0012345)2.41065689
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39238647
67Abnormality of chromosome stability (HP:0003220)2.38760551
68Respiratory failure (HP:0002878)2.38053561
69Respiratory difficulties (HP:0002880)2.35999053
70CNS hypomyelination (HP:0003429)2.35294428
71Secondary amenorrhea (HP:0000869)2.34264996
72Duplicated collecting system (HP:0000081)2.33793675
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33674049
74Methylmalonic aciduria (HP:0012120)2.32422795
75Aplasia involving forearm bones (HP:0009822)2.31908962
76Absent forearm bone (HP:0003953)2.31908962
77Increased intramyocellular lipid droplets (HP:0012240)2.29671207
78Pancytopenia (HP:0001876)2.29593689
79Horseshoe kidney (HP:0000085)2.29282957
80Bone marrow hypocellularity (HP:0005528)2.29186226
81Colon cancer (HP:0003003)2.26022797
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25862491
83Abnormality of alanine metabolism (HP:0010916)2.25862491
84Hyperalaninemia (HP:0003348)2.25862491
85Sparse eyelashes (HP:0000653)2.24015168
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.20962332
87Pancreatic fibrosis (HP:0100732)2.18289797
88Trismus (HP:0000211)2.17667516
89CNS demyelination (HP:0007305)2.16126564
90Dicarboxylic aciduria (HP:0003215)2.14773546
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14773546
92Premature ovarian failure (HP:0008209)2.14529622
93Cleft eyelid (HP:0000625)2.13787469
94Type 2 muscle fiber atrophy (HP:0003554)2.13667797
95Triphalangeal thumb (HP:0001199)2.13470865
96Hyperglycinemia (HP:0002154)2.12910808
97Hyperphosphaturia (HP:0003109)2.12433196
98Hypoglycemic coma (HP:0001325)2.11427136
99Cerebral edema (HP:0002181)2.10572632
100Muscle fiber atrophy (HP:0100295)2.09847514
101Molar tooth sign on MRI (HP:0002419)2.05652023
102Abnormality of midbrain morphology (HP:0002418)2.05652023
103X-linked dominant inheritance (HP:0001423)2.05084172
104Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04402207
105Hyperthyroidism (HP:0000836)2.01630418
106Selective tooth agenesis (HP:0001592)2.01198593
107Ketoacidosis (HP:0001993)2.00470358
108Duodenal stenosis (HP:0100867)1.99948003
109Small intestinal stenosis (HP:0012848)1.99948003
110Abnormality of the renal collecting system (HP:0004742)1.99623534
111Nausea (HP:0002018)1.98971864
112Medial flaring of the eyebrow (HP:0010747)1.98873687
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.98511959
114Abnormality of methionine metabolism (HP:0010901)1.97969343
115Reduced antithrombin III activity (HP:0001976)1.97399898
116Cellular immunodeficiency (HP:0005374)1.97129785
117Abnormality of serum amino acid levels (HP:0003112)1.97052967
118Irregular epiphyses (HP:0010582)1.96916886
119Myelodysplasia (HP:0002863)1.96511549
120Abnormal lung lobation (HP:0002101)1.95315057
121Ureteral duplication (HP:0000073)1.94353909
122True hermaphroditism (HP:0010459)1.93408979
123Increased muscle lipid content (HP:0009058)1.93088370
124Progressive microcephaly (HP:0000253)1.92160148
125Pancreatic cysts (HP:0001737)1.92137138
126Hypokinesia (HP:0002375)1.90717942
127Poor head control (HP:0002421)1.90654603
128Aplasia/hypoplasia of the uterus (HP:0008684)1.90574409
129Hypoplasia of the radius (HP:0002984)1.87358246
130Palpitations (HP:0001962)1.85475179
131Megaloblastic anemia (HP:0001889)1.85390865
132Progressive muscle weakness (HP:0003323)1.84603538
133Blindness (HP:0000618)1.83795526
134Emotional lability (HP:0000712)1.83725706
135Vomiting (HP:0002013)1.82455651
136Opisthotonus (HP:0002179)1.82323890
137Hyperinsulinemic hypoglycemia (HP:0000825)1.77809167
138Metabolic acidosis (HP:0001942)1.77344720
139Testicular atrophy (HP:0000029)1.75966661
140Sclerocornea (HP:0000647)1.75519452
141Ketosis (HP:0001946)1.74191876
142Renal cortical cysts (HP:0000803)1.72236207
143Delayed CNS myelination (HP:0002188)1.70515393
144Hypothermia (HP:0002045)1.70043253
145Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68133360
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67665375
147Nephronophthisis (HP:0000090)1.63564851
148Hypoplasia of the pons (HP:0012110)1.58174130
149Abnormality of the pons (HP:0007361)1.57633100
150Truncus arteriosus (HP:0001660)1.55405605
151Gliosis (HP:0002171)1.54674223
152Hypoplasia of the uterus (HP:0000013)1.53964389
153Abnormality of vitamin B metabolism (HP:0004340)1.52843147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11047477
2WEE14.42411208
3STK164.36071562
4VRK23.97195718
5EIF2AK13.88439730
6NME23.52283772
7PLK42.72033429
8SRPK12.70266242
9CDC72.67323728
10VRK12.37482226
11EIF2AK32.33372775
12PDK22.22305433
13TLK12.12706530
14BRSK22.11488732
15ACVR1B2.07856037
16TSSK61.95534861
17MAP3K121.85500574
18TTK1.81638614
19PLK11.77985186
20NEK21.76956396
21TESK21.67833614
22WNK41.66025954
23ZAK1.63704096
24DYRK31.57124984
25NEK11.54858055
26PIM21.52585387
27MAP4K21.47845612
28NME11.47418460
29AURKB1.41419202
30FRK1.40699527
31PLK31.35105166
32CDK71.34476404
33AURKA1.32949711
34IRAK31.32809010
35CCNB11.31242169
36MKNK11.29092295
37BRSK11.27554738
38EIF2AK21.23605960
39PHKG21.23571438
40PHKG11.23571438
41BRAF1.22639527
42CHEK21.19941226
43TRIM281.19666280
44INSRR1.19011040
45ATR1.10866113
46MST41.10438255
47BCKDK1.07230527
48RPS6KA41.06549468
49MKNK21.06036673
50PASK1.05859711
51PBK1.05615454
52EPHA21.04451286
53WNK31.00939330
54ARAF0.99410909
55CSNK1G20.98741884
56KDR0.98201808
57STK38L0.94659464
58DYRK20.92403562
59RPS6KB20.89523799
60CSNK1A1L0.88887926
61CDK80.86451594
62DAPK10.84537545
63AKT30.83549855
64STK390.81674769
65MAP3K80.80419592
66IRAK40.79652703
67CSNK2A10.79104551
68CDK190.78676831
69CHEK10.76552688
70STK40.75374660
71CSNK2A20.73026288
72PAK10.69620592
73RPS6KA50.67522920
74PLK20.66074649
75ABL20.65832097
76DAPK30.63194936
77MAP3K110.61432643
78PINK10.59183027
79ERBB30.59171932
80PRKCI0.57981624
81CDK40.57615655
82MAPKAPK50.55931499
83MAPK150.55285279
84BMPR1B0.54137749
85PAK40.53414857
86TEC0.52944920
87PIM10.52050100
88NTRK30.51212375
89PNCK0.49662861
90LIMK10.48157316
91ATM0.47864816
92CAMKK20.47749616
93STK240.47551587
94TGFBR10.46557555
95CDK20.45842458
96MAP2K60.43669488
97TESK10.42667487
98TXK0.42316697
99CSNK1G30.42224825
100CAMK2D0.41794867
101SCYL20.41685694
102LRRK20.41385205
103CAMK2G0.40932622
104ILK0.39863455
105PDK40.38997746
106PDK30.38997746
107MAPK130.37821143
108FLT30.36861214
109OBSCN0.36178610
110MAP2K70.35853302
111ADRBK10.35671680
112AKT20.34096629
113CDK10.33880908
114OXSR10.33820810
115CSNK1A10.33799869
116CSNK1E0.33565552
117PRKCG0.33341508
118MYLK0.33255270
119STK30.32989141
120MAP3K40.31950847
121ADRBK20.31808085
122TAF10.31384623
123MAP4K10.29163743
124CLK10.28794630
125STK100.27339295
126NLK0.26890814
127IRAK20.24670469
128CSNK1G10.24464024
129RAF10.24090009
130MUSK0.23066659
131GRK10.22951512
132BLK0.22689078
133YES10.22620669
134MAPKAPK30.22024424
135BCR0.21436064
136NUAK10.20949223
137IKBKB0.20422872
138MARK30.18756898

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.38393068
2Ribosome_Homo sapiens_hsa030104.37857087
3DNA replication_Homo sapiens_hsa030304.26464234
4RNA polymerase_Homo sapiens_hsa030204.11285309
5Mismatch repair_Homo sapiens_hsa034303.68402805
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49128200
7Homologous recombination_Homo sapiens_hsa034402.91114623
8Spliceosome_Homo sapiens_hsa030402.83001648
9Pyrimidine metabolism_Homo sapiens_hsa002402.81768815
10Nucleotide excision repair_Homo sapiens_hsa034202.68252123
11Base excision repair_Homo sapiens_hsa034102.58863652
12RNA transport_Homo sapiens_hsa030132.55201260
13Oxidative phosphorylation_Homo sapiens_hsa001902.18001742
14Parkinsons disease_Homo sapiens_hsa050122.05520928
15Basal transcription factors_Homo sapiens_hsa030222.04289562
16Fanconi anemia pathway_Homo sapiens_hsa034602.03152333
17One carbon pool by folate_Homo sapiens_hsa006702.01512732
18Cell cycle_Homo sapiens_hsa041101.96514325
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81520832
20Non-homologous end-joining_Homo sapiens_hsa034501.75887458
21Huntingtons disease_Homo sapiens_hsa050161.72638653
22Protein export_Homo sapiens_hsa030601.72588347
23Propanoate metabolism_Homo sapiens_hsa006401.65720371
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63139971
25RNA degradation_Homo sapiens_hsa030181.62194840
26Purine metabolism_Homo sapiens_hsa002301.61770662
27Sulfur metabolism_Homo sapiens_hsa009201.53811070
28Vitamin B6 metabolism_Homo sapiens_hsa007501.48343449
29Butanoate metabolism_Homo sapiens_hsa006501.35152254
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.33452449
31Folate biosynthesis_Homo sapiens_hsa007901.29742942
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17372413
33p53 signaling pathway_Homo sapiens_hsa041151.15667989
34Collecting duct acid secretion_Homo sapiens_hsa049661.14640983
35Alzheimers disease_Homo sapiens_hsa050101.14505900
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12593663
37mRNA surveillance pathway_Homo sapiens_hsa030151.03213953
38Pentose phosphate pathway_Homo sapiens_hsa000301.03147608
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02350218
40Epstein-Barr virus infection_Homo sapiens_hsa051691.02250905
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96782096
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.94681907
43Sulfur relay system_Homo sapiens_hsa041220.92720003
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.85610250
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.84791650
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83632240
47Glutathione metabolism_Homo sapiens_hsa004800.83369254
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83152120
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81883472
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80416947
51Systemic lupus erythematosus_Homo sapiens_hsa053220.77582391
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73944001
53Fatty acid metabolism_Homo sapiens_hsa012120.72996438
54Regulation of autophagy_Homo sapiens_hsa041400.70825469
55Fatty acid degradation_Homo sapiens_hsa000710.70353386
56Tryptophan metabolism_Homo sapiens_hsa003800.69246088
57Antigen processing and presentation_Homo sapiens_hsa046120.66150999
58Biosynthesis of amino acids_Homo sapiens_hsa012300.65502971
59Metabolic pathways_Homo sapiens_hsa011000.65028810
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64086187
61Chemical carcinogenesis_Homo sapiens_hsa052040.63937237
62Arachidonic acid metabolism_Homo sapiens_hsa005900.62861638
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61442330
64Carbon metabolism_Homo sapiens_hsa012000.61229132
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60239669
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.57436427
67Linoleic acid metabolism_Homo sapiens_hsa005910.57242478
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56530166
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54714553
70Oocyte meiosis_Homo sapiens_hsa041140.53606947
71Caffeine metabolism_Homo sapiens_hsa002320.50768894
72Cardiac muscle contraction_Homo sapiens_hsa042600.50663923
73Vibrio cholerae infection_Homo sapiens_hsa051100.50015354
74Herpes simplex infection_Homo sapiens_hsa051680.49413515
75Primary immunodeficiency_Homo sapiens_hsa053400.48050279
76Arginine biosynthesis_Homo sapiens_hsa002200.47532733
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47403079
78Retinol metabolism_Homo sapiens_hsa008300.47362007
79Fructose and mannose metabolism_Homo sapiens_hsa000510.46523170
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45864053
81Arginine and proline metabolism_Homo sapiens_hsa003300.41763629
82Phototransduction_Homo sapiens_hsa047440.39175746
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38784576
84Selenocompound metabolism_Homo sapiens_hsa004500.38200395
85Fatty acid elongation_Homo sapiens_hsa000620.37540592
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37135309
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36963406
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36792176
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.35053492
90Viral carcinogenesis_Homo sapiens_hsa052030.34696743
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34363989
92Nitrogen metabolism_Homo sapiens_hsa009100.30940992
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30026068
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29422074
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28309092
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27784621
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.27381330
98Galactose metabolism_Homo sapiens_hsa000520.27359181
99Steroid biosynthesis_Homo sapiens_hsa001000.23937469
100Pyruvate metabolism_Homo sapiens_hsa006200.22137472
101Fat digestion and absorption_Homo sapiens_hsa049750.21722846
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21296287
103Allograft rejection_Homo sapiens_hsa053300.20491334
104Tyrosine metabolism_Homo sapiens_hsa003500.19880660
105Graft-versus-host disease_Homo sapiens_hsa053320.19817763
106Ether lipid metabolism_Homo sapiens_hsa005650.19446275
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19364787
108Legionellosis_Homo sapiens_hsa051340.19301878
109Vitamin digestion and absorption_Homo sapiens_hsa049770.19275559
110Synaptic vesicle cycle_Homo sapiens_hsa047210.18898002
111HTLV-I infection_Homo sapiens_hsa051660.17302254
112Autoimmune thyroid disease_Homo sapiens_hsa053200.16377513
113Phenylalanine metabolism_Homo sapiens_hsa003600.13933071
114Thyroid cancer_Homo sapiens_hsa052160.13277843
115Alcoholism_Homo sapiens_hsa050340.12947624
116N-Glycan biosynthesis_Homo sapiens_hsa005100.12830942
117Peroxisome_Homo sapiens_hsa041460.11528634
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10845217
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09705096
120beta-Alanine metabolism_Homo sapiens_hsa004100.09373552
121Renin-angiotensin system_Homo sapiens_hsa046140.08240000
122Measles_Homo sapiens_hsa051620.08059706
123Asthma_Homo sapiens_hsa053100.07411871
124Sphingolipid metabolism_Homo sapiens_hsa006000.05916004
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05880632
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.05768753
127Hematopoietic cell lineage_Homo sapiens_hsa046400.05590345

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