MRPL41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.70471221
2ATP synthesis coupled proton transport (GO:0015986)8.18659644
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.18659644
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.77857932
5respiratory electron transport chain (GO:0022904)6.86505021
6electron transport chain (GO:0022900)6.70087289
7chaperone-mediated protein transport (GO:0072321)5.91386320
8protein complex biogenesis (GO:0070271)5.22065424
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.14893206
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.09989930
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.09989930
12NADH dehydrogenase complex assembly (GO:0010257)5.09989930
13protein neddylation (GO:0045116)5.05161480
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.99289168
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.77497699
16protein maturation by protein folding (GO:0022417)4.75844377
17GDP-mannose metabolic process (GO:0019673)4.74202817
18NADH metabolic process (GO:0006734)4.67058128
19mitochondrial respiratory chain complex assembly (GO:0033108)4.65727452
20hydrogen ion transmembrane transport (GO:1902600)4.47225550
21ATP biosynthetic process (GO:0006754)4.41699486
22purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.27017433
23inner mitochondrial membrane organization (GO:0007007)4.24327265
24purine nucleoside triphosphate biosynthetic process (GO:0009145)4.20034226
25regulation of mitochondrial translation (GO:0070129)4.02244843
26proton transport (GO:0015992)3.97684613
27hydrogen transport (GO:0006818)3.89506339
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86407770
29cullin deneddylation (GO:0010388)3.85850593
30iron-sulfur cluster assembly (GO:0016226)3.79794269
31metallo-sulfur cluster assembly (GO:0031163)3.79794269
32energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.79619785
33ATP hydrolysis coupled proton transport (GO:0015991)3.79619785
34ribonucleoside triphosphate biosynthetic process (GO:0009201)3.77268528
35GTP biosynthetic process (GO:0006183)3.75630250
36proteasome assembly (GO:0043248)3.72675347
37dopamine transport (GO:0015872)3.72185786
38oxidative phosphorylation (GO:0006119)3.68953612
39maturation of SSU-rRNA (GO:0030490)3.65236578
40translational elongation (GO:0006414)3.63760255
41respiratory chain complex IV assembly (GO:0008535)3.63374244
42protein deneddylation (GO:0000338)3.61471076
43neuron cell-cell adhesion (GO:0007158)3.56897632
44protein targeting to mitochondrion (GO:0006626)3.51541066
45deoxyribose phosphate biosynthetic process (GO:0046385)3.50226856
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.50226856
47regulation of oxidative phosphorylation (GO:0002082)3.48315559
48establishment of protein localization to mitochondrion (GO:0072655)3.46494677
49ribosomal small subunit assembly (GO:0000028)3.42874670
50nucleobase-containing small molecule interconversion (GO:0015949)3.38115913
51nucleoside triphosphate biosynthetic process (GO:0009142)3.32640140
52regulation of dopamine metabolic process (GO:0042053)3.30865313
53regulation of catecholamine metabolic process (GO:0042069)3.30865313
54cytochrome complex assembly (GO:0017004)3.30739951
55oxaloacetate metabolic process (GO:0006107)3.29683180
56viral life cycle (GO:0019058)3.29105709
57deoxyribonucleotide catabolic process (GO:0009264)3.26653809
58nucleoside diphosphate biosynthetic process (GO:0009133)3.26399096
59protein localization to mitochondrion (GO:0070585)3.26166340
60regulation of cellular respiration (GO:0043457)3.22110782
61creatine metabolic process (GO:0006600)3.21627469
62guanosine-containing compound biosynthetic process (GO:1901070)3.15170279
63proline biosynthetic process (GO:0006561)3.14498970
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.12058511
65termination of RNA polymerase III transcription (GO:0006386)3.12058511
66nucleotide salvage (GO:0043173)3.10868000
67ribosomal small subunit biogenesis (GO:0042274)3.09218672
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07030699
69negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.06865568
70aerobic respiration (GO:0009060)3.06571466
71UTP biosynthetic process (GO:0006228)3.06262596
72transferrin transport (GO:0033572)3.05994161
73dopamine biosynthetic process (GO:0042416)3.05920328
74pyrimidine nucleotide catabolic process (GO:0006244)3.04503650
75protein retention in ER lumen (GO:0006621)3.04135196
76base-excision repair, AP site formation (GO:0006285)3.03603046
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03064062
78regulation of cellular amino acid metabolic process (GO:0006521)2.99028275
79neuronal action potential propagation (GO:0019227)2.98859084
80nuclear envelope reassembly (GO:0031468)2.98183915
81mitotic nuclear envelope reassembly (GO:0007084)2.98183915
82cellular protein complex disassembly (GO:0043624)2.97769606
83deoxyribose phosphate catabolic process (GO:0046386)2.97206687
84mitochondrial transport (GO:0006839)2.95929815
85protein localization to cilium (GO:0061512)2.94769245
86gluconeogenesis (GO:0006094)2.94748243
877-methylguanosine mRNA capping (GO:0006370)2.94555718
88purine deoxyribonucleotide catabolic process (GO:0009155)2.94547300
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93818828
90establishment of integrated proviral latency (GO:0075713)2.93465168
91substantia nigra development (GO:0021762)2.92488585
927-methylguanosine RNA capping (GO:0009452)2.92430792
93RNA capping (GO:0036260)2.92430792
94presynaptic membrane assembly (GO:0097105)2.91089359
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90211677
96L-phenylalanine metabolic process (GO:0006558)2.89640764
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.89640764
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88866210
99synaptic vesicle exocytosis (GO:0016079)2.87624404
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84161196
101tricarboxylic acid cycle (GO:0006099)2.83055153
1022-deoxyribonucleotide metabolic process (GO:0009394)2.82926425
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81979354
104synaptic transmission, dopaminergic (GO:0001963)2.80071151
105monosaccharide biosynthetic process (GO:0046364)2.78889917
106protein-cofactor linkage (GO:0018065)2.78599591
107trivalent inorganic cation transport (GO:0072512)2.78381295
108ferric iron transport (GO:0015682)2.78381295
109purine nucleotide salvage (GO:0032261)2.78041623
110negative regulation of cell size (GO:0045792)2.77843010
111pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75884283
112* translation (GO:0006412)2.75286585
113hexose biosynthetic process (GO:0019319)2.74293087
114negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73511062
115mitochondrial fusion (GO:0008053)2.72213702
116pentose metabolic process (GO:0019321)2.72200724
117neurotransmitter uptake (GO:0001504)2.71918297
118CTP biosynthetic process (GO:0006241)2.70811309
119CTP metabolic process (GO:0046036)2.70811309
120regulation of protein kinase A signaling (GO:0010738)2.70479139
121presynaptic membrane organization (GO:0097090)2.70314192
122establishment of viral latency (GO:0019043)2.70233748
123regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.69358893
124long-chain fatty acid biosynthetic process (GO:0042759)2.68402788
125purine deoxyribonucleotide metabolic process (GO:0009151)2.66564596
126cotranslational protein targeting to membrane (GO:0006613)2.66540324
127intracellular protein transmembrane import (GO:0044743)2.66403562
128calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66238812
129prostanoid biosynthetic process (GO:0046457)2.65858085
130prostaglandin biosynthetic process (GO:0001516)2.65858085
131mitochondrial calcium ion transport (GO:0006851)2.65596293
132ubiquinone biosynthetic process (GO:0006744)2.65372036
133quinone biosynthetic process (GO:1901663)2.65372036
134mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.64204921
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63813447
136nucleoside diphosphate phosphorylation (GO:0006165)2.62984441
137deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.62863790
138viral transcription (GO:0019083)2.62766922
139protein localization to synapse (GO:0035418)2.62579529
140positive regulation of mitochondrial fission (GO:0090141)2.60653830
141regulation of cellular amine metabolic process (GO:0033238)2.59549402
142UTP metabolic process (GO:0046051)2.58716765
143fatty acid elongation (GO:0030497)2.58475544
144mannosylation (GO:0097502)2.56716803
145positive regulation of protein homodimerization activity (GO:0090073)2.56495202
146ubiquinone metabolic process (GO:0006743)2.56478974
147purine nucleoside monophosphate biosynthetic process (GO:0009127)2.56360385
148purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.56360385
149protein targeting to ER (GO:0045047)2.56083398
150negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55092396
151negative regulation of ligase activity (GO:0051352)2.55092396
152translational termination (GO:0006415)2.54828840
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53535927
154protein localization to endoplasmic reticulum (GO:0070972)2.51810642
155regulation of glutamate secretion (GO:0014048)2.51442800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.41967080
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94044781
3EZH2_22144423_ChIP-Seq_EOC_Human3.88939886
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56366080
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.53853129
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14478428
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06426994
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03360875
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02681027
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99408402
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83251791
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78191409
13TAF15_26573619_Chip-Seq_HEK293_Human2.74850425
14GBX2_23144817_ChIP-Seq_PC3_Human2.73279625
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71247608
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.57484749
17VDR_22108803_ChIP-Seq_LS180_Human2.43467073
18LXR_22292898_ChIP-Seq_THP-1_Human2.41498360
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34096816
20ZNF263_19887448_ChIP-Seq_K562_Human2.29913537
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28550815
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24078165
23VDR_21846776_ChIP-Seq_THP-1_Human2.22382826
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21091634
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18279249
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16493413
27TET1_21451524_ChIP-Seq_MESCs_Mouse2.15030291
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00181037
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97479920
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.96892453
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96299524
32P68_20966046_ChIP-Seq_HELA_Human1.91247512
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89560185
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87889084
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85571117
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80370560
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.80084662
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76069138
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75902303
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73307487
41RACK7_27058665_Chip-Seq_MCF-7_Human1.71140189
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70908348
43FUS_26573619_Chip-Seq_HEK293_Human1.70397163
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67116868
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66043720
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64417658
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.63212711
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62674741
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62336008
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60693185
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60527900
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.59434467
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.59174594
54REST_21632747_ChIP-Seq_MESCs_Mouse1.58888894
55VDR_23849224_ChIP-Seq_CD4+_Human1.57389429
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56625362
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54320575
58DCP1A_22483619_ChIP-Seq_HELA_Human1.54287027
59BCL6_27268052_Chip-Seq_Bcells_Human1.53201392
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.49199431
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.48762276
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48511604
63IGF1R_20145208_ChIP-Seq_DFB_Human1.46657552
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45437788
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.45380144
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45132209
67BCOR_27268052_Chip-Seq_Bcells_Human1.44165416
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.43629703
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42565764
70* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42073338
71P300_19829295_ChIP-Seq_ESCs_Human1.41008615
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40419704
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40068691
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39755153
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38939254
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37162153
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.35772981
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35544664
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35438870
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34852457
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34695195
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.34418606
83SMC4_20622854_ChIP-Seq_HELA_Human1.33664818
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33165601
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32274432
86ER_23166858_ChIP-Seq_MCF-7_Human1.31110642
87ELK1_19687146_ChIP-ChIP_HELA_Human1.31020795
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.30583231
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.29192978
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28942362
91CTCF_27219007_Chip-Seq_Bcells_Human1.27615960
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27105711
93FOXP3_21729870_ChIP-Seq_TREG_Human1.26817431
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26626694
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25926603
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23952445
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23230432
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23114024
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23090652
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22717809
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22708285
102* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22152467
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21793195
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20724365
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.19695811
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19250975
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18847211
108PHF8_20622854_ChIP-Seq_HELA_Human1.18552366
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18490358
110E2F1_20622854_ChIP-Seq_HELA_Human1.16994696
111MYC_22102868_ChIP-Seq_BL_Human1.16472547
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16177862
113SA1_27219007_Chip-Seq_Bcells_Human1.15895661
114TTF2_22483619_ChIP-Seq_HELA_Human1.15753664
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.15462938
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14544935
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14376235
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14247004
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13853423
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13565734
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13198453
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13153253
123KDM2B_26808549_Chip-Seq_DND41_Human1.13034239
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12851651
125STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11942875
126ZNF274_21170338_ChIP-Seq_K562_Hela1.11901596
127CTCF_21964334_Chip-Seq_Bcells_Human1.11487195
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11417661
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11299891
130FLI1_27457419_Chip-Seq_LIVER_Mouse1.10865572
131* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10698402
132ELK1_22589737_ChIP-Seq_MCF10A_Human1.10493664
133CTCF_20526341_ChIP-Seq_ESCs_Human1.10154044
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10044696
135IRF1_19129219_ChIP-ChIP_H3396_Human1.10027347
136DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09217100
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08879237
138EWS_26573619_Chip-Seq_HEK293_Human1.08736076
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08544352
140PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08284302
141EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07679003
142RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07679003
143MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07608870
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07472424
145TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07205058
146JUN_21703547_ChIP-Seq_K562_Human1.06141052
147CREB1_26743006_Chip-Seq_LNCaP_Human1.06007127
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.05958318
149RARB_24833708_ChIP-Seq_LIVER_Mouse1.05475118
150* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05279342
151MAF_26560356_Chip-Seq_TH2_Human1.04425360
152OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04119438
153ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03275508
154ESR2_21235772_ChIP-Seq_MCF-7_Human1.03008122
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02718953
156RNF2_27304074_Chip-Seq_NSC_Mouse1.02030713
157EZH2_27294783_Chip-Seq_ESCs_Mouse1.02001595
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01168961
159SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01032537
160HTT_18923047_ChIP-ChIP_STHdh_Human1.00688538
161GABP_19822575_ChIP-Seq_HepG2_Human0.99476527
162RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98960384
163XRN2_22483619_ChIP-Seq_HELA_Human0.98835028
164SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98587126
165MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98570555
166IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98164832
167YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97114784
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95049153
169REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88126563
170CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86804302
171NANOG_19829295_ChIP-Seq_ESCs_Human0.86515929
172SOX2_19829295_ChIP-Seq_ESCs_Human0.86515929
173* MYC_18940864_ChIP-ChIP_HL60_Human0.86262620
174SMAD4_21799915_ChIP-Seq_A2780_Human0.85831898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.14622593
2MP0005451_abnormal_body_composition4.43384780
3MP0001529_abnormal_vocalization4.10764362
4MP0005058_abnormal_lysosome_morphology3.48296520
5MP0006276_abnormal_autonomic_nervous3.13133000
6MP0001905_abnormal_dopamine_level3.08718574
7MP0002736_abnormal_nociception_after2.94321021
8MP0003806_abnormal_nucleotide_metabolis2.93005400
9MP0001968_abnormal_touch/_nociception2.92819436
10MP0008260_abnormal_autophagy2.80580699
11MP0005670_abnormal_white_adipose2.70958760
12MP0002735_abnormal_chemical_nociception2.66005174
13MP0004859_abnormal_synaptic_plasticity2.57840513
14MP0009840_abnormal_foam_cell2.56793747
15MP0009745_abnormal_behavioral_response2.55686656
16MP0000750_abnormal_muscle_regeneration2.55669692
17MP0003635_abnormal_synaptic_transmissio2.53827991
18MP0002064_seizures2.50845367
19MP0002272_abnormal_nervous_system2.50609055
20MP0009046_muscle_twitch2.42658742
21MP0004858_abnormal_nervous_system2.41762113
22MP0004270_analgesia2.35900884
23MP0009379_abnormal_foot_pigmentation2.29076518
24MP0002734_abnormal_mechanical_nocicepti2.25331767
25MP0000747_muscle_weakness2.24064166
26MP0005330_cardiomyopathy2.22788008
27MP0002837_dystrophic_cardiac_calcinosis2.22427277
28MP0002572_abnormal_emotion/affect_behav2.17609079
29MP0003186_abnormal_redox_activity2.17332076
30MP0004510_myositis2.14103047
31MP0004142_abnormal_muscle_tone2.13806806
32MP0001984_abnormal_olfaction2.11217650
33MP0001440_abnormal_grooming_behavior2.09969955
34MP0005423_abnormal_somatic_nervous2.05200551
35MP0002063_abnormal_learning/memory/cond2.02171299
36MP0001188_hyperpigmentation1.92791096
37MP0001970_abnormal_pain_threshold1.92265121
38MP0006036_abnormal_mitochondrial_physio1.90174421
39MP0002733_abnormal_thermal_nociception1.82270852
40MP0002067_abnormal_sensory_capabilities1.81270205
41MP0004233_abnormal_muscle_weight1.81127004
42MP0003122_maternal_imprinting1.80961426
43MP0000759_abnormal_skeletal_muscle1.76459006
44MP0001486_abnormal_startle_reflex1.75897390
45MP0001986_abnormal_taste_sensitivity1.74317702
46MP0006035_abnormal_mitochondrial_morpho1.72362105
47MP0001501_abnormal_sleep_pattern1.69531400
48MP0002638_abnormal_pupillary_reflex1.66892648
49MP0004924_abnormal_behavior1.63664222
50MP0005386_behavior/neurological_phenoty1.63664222
51MP0004087_abnormal_muscle_fiber1.59296150
52MP0003075_altered_response_to1.53750277
53MP0002184_abnormal_innervation1.53449643
54MP0005551_abnormal_eye_electrophysiolog1.50663397
55MP0005666_abnormal_adipose_tissue1.49645801
56MP0002822_catalepsy1.49549173
57MP0005645_abnormal_hypothalamus_physiol1.46690339
58MP0002876_abnormal_thyroid_physiology1.42192989
59MP0004185_abnormal_adipocyte_glucose1.39778166
60MP0002163_abnormal_gland_morphology1.37592352
61MP0005409_darkened_coat_color1.35290283
62MP0000678_abnormal_parathyroid_gland1.33010397
63MP0004215_abnormal_myocardial_fiber1.33002972
64MP0005165_increased_susceptibility_to1.30437658
65MP0002106_abnormal_muscle_physiology1.29625840
66MP0005375_adipose_tissue_phenotype1.29625263
67MP0000778_abnormal_nervous_system1.29357635
68MP0001661_extended_life_span1.26365945
69MP0002269_muscular_atrophy1.25633922
70MP0004147_increased_porphyrin_level1.24839717
71MP0002557_abnormal_social/conspecific_i1.24374488
72MP0005379_endocrine/exocrine_gland_phen1.23165793
73MP0006072_abnormal_retinal_apoptosis1.22459284
74MP0003136_yellow_coat_color1.22360579
75MP0005171_absent_coat_pigmentation1.21458920
76MP0004742_abnormal_vestibular_system1.18804255
77MP0000751_myopathy1.17502991
78MP0010386_abnormal_urinary_bladder1.17158653
79MP0005584_abnormal_enzyme/coenzyme_acti1.15799537
80MP0003329_amyloid_beta_deposits1.15751395
81MP0000343_altered_response_to1.15560832
82MP0002066_abnormal_motor_capabilities/c1.14827485
83MP0002229_neurodegeneration1.13882527
84MP0003705_abnormal_hypodermis_morpholog1.13768528
85MP0004145_abnormal_muscle_electrophysio1.13725088
86MP0000003_abnormal_adipose_tissue1.12673208
87MP0002653_abnormal_ependyma_morphology1.11525859
88MP0005646_abnormal_pituitary_gland1.11406573
89MP0002882_abnormal_neuron_morphology1.11318281
90MP0009333_abnormal_splenocyte_physiolog1.10326619
91MP0000372_irregular_coat_pigmentation1.10230361
92MP0005501_abnormal_skin_physiology1.09219590
93MP0003879_abnormal_hair_cell1.07857429
94MP0002249_abnormal_larynx_morphology1.07158844
95MP0000681_abnormal_thyroid_gland1.06183877
96MP0005369_muscle_phenotype1.05181846
97MP0003191_abnormal_cellular_cholesterol1.02681521
98MP0001485_abnormal_pinna_reflex1.01773700
99MP0008874_decreased_physiological_sensi1.01197855
100MP0008872_abnormal_physiological_respon1.00239005
101MP0000920_abnormal_myelination0.99803141
102MP0003123_paternal_imprinting0.98919768
103MP0002751_abnormal_autonomic_nervous0.97692154
104MP0002752_abnormal_somatic_nervous0.97136661
105MP0003646_muscle_fatigue0.96927019
106MP0000955_abnormal_spinal_cord0.96552248
107MP0002972_abnormal_cardiac_muscle0.96226482
108MP0001502_abnormal_circadian_rhythm0.94521881
109MP0001963_abnormal_hearing_physiology0.94052596
110MP0001764_abnormal_homeostasis0.92954582
111MP0000358_abnormal_cell_content/0.92195307
112MP0004130_abnormal_muscle_cell0.91642594
113MP0010030_abnormal_orbit_morphology0.91122283
114MP0005332_abnormal_amino_acid0.90534448
115MP0008569_lethality_at_weaning0.89386691
116MP0003137_abnormal_impulse_conducting0.89251141
117MP0005410_abnormal_fertilization0.88975259
118MP0005253_abnormal_eye_physiology0.88552595
119MP0004811_abnormal_neuron_physiology0.86445222
120MP0005535_abnormal_body_temperature0.86231236
121MP0006292_abnormal_olfactory_placode0.85442963
122MP0008877_abnormal_DNA_methylation0.84953668
123MP0004036_abnormal_muscle_relaxation0.84732428
124MP0000733_abnormal_muscle_development0.84356510
125MP0005319_abnormal_enzyme/_coenzyme0.84181177
126MP0009697_abnormal_copulation0.83615787
127MP0003786_premature_aging0.82988148
128MP0001664_abnormal_digestion0.82453607
129MP0002796_impaired_skin_barrier0.82357165
130MP0001873_stomach_inflammation0.81710964
131MP0005394_taste/olfaction_phenotype0.81311683
132MP0005499_abnormal_olfactory_system0.81311683
133MP0004085_abnormal_heartbeat0.80730957
134MP0001727_abnormal_embryo_implantation0.79840822
135MP0000749_muscle_degeneration0.78416375
136MP0000631_abnormal_neuroendocrine_gland0.77296017
137MP0002089_abnormal_postnatal_growth/wei0.77225952
138MP0005083_abnormal_biliary_tract0.77102915
139MP0005266_abnormal_metabolism0.76972426
140MP0001348_abnormal_lacrimal_gland0.75791622
141MP0009643_abnormal_urine_homeostasis0.75598304
142MP0005620_abnormal_muscle_contractility0.74967572
143MP0002139_abnormal_hepatobiliary_system0.74896955
144MP0000026_abnormal_inner_ear0.74867204
145MP0005166_decreased_susceptibility_to0.73962626
146MP0008789_abnormal_olfactory_epithelium0.73780892
147MP0002332_abnormal_exercise_endurance0.73011778
148MP0002938_white_spotting0.71938901
149MP0005636_abnormal_mineral_homeostasis0.71858953
150MP0010630_abnormal_cardiac_muscle0.71343015
151MP0000015_abnormal_ear_pigmentation0.68985825
152MP0003787_abnormal_imprinting0.68004217
153MP0003172_abnormal_lysosome_physiology0.67825936
154MP0000858_altered_metastatic_potential0.67653012
155MP0003121_genomic_imprinting0.67232539
156MP0005084_abnormal_gallbladder_morpholo0.67138939
157MP0002102_abnormal_ear_morphology0.66326556
158MP0000230_abnormal_systemic_arterial0.64746960
159MP0003011_delayed_dark_adaptation0.64621722
160MP0002152_abnormal_brain_morphology0.64056820
161MP0001542_abnormal_bone_strength0.63239556
162MP0006138_congestive_heart_failure0.62693795
163MP0009278_abnormal_bone_marrow0.62669940
164MP0000604_amyloidosis0.62059464
165MP0003693_abnormal_embryo_hatching0.61958247
166MP0008875_abnormal_xenobiotic_pharmacok0.56552308
167MP0002118_abnormal_lipid_homeostasis0.56525832
168MP0001881_abnormal_mammary_gland0.55353347

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.08789499
2Abnormal mitochondria in muscle tissue (HP:0008316)6.49412037
3Mitochondrial inheritance (HP:0001427)6.27276842
4Progressive macrocephaly (HP:0004481)6.03954669
5Acute encephalopathy (HP:0006846)5.69483195
6Hepatocellular necrosis (HP:0001404)5.49586529
7Increased CSF lactate (HP:0002490)5.38112335
8Increased hepatocellular lipid droplets (HP:0006565)4.72733941
9Hepatic necrosis (HP:0002605)4.59432996
10Lipid accumulation in hepatocytes (HP:0006561)4.17730127
11Focal motor seizures (HP:0011153)4.06819061
12Abnormality of glycolysis (HP:0004366)4.01877455
13Increased serum pyruvate (HP:0003542)4.01877455
14Renal Fanconi syndrome (HP:0001994)3.99338641
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.85220386
16Cerebral edema (HP:0002181)3.83118038
17Optic disc pallor (HP:0000543)3.81423980
18Ragged-red muscle fibers (HP:0003200)3.73638667
19Increased intramyocellular lipid droplets (HP:0012240)3.70535635
20Respiratory failure (HP:0002878)3.65873152
21Distal lower limb muscle weakness (HP:0009053)3.63705070
223-Methylglutaconic aciduria (HP:0003535)3.62633137
23Exercise intolerance (HP:0003546)3.60757579
24Myokymia (HP:0002411)3.58623864
25Myopathic facies (HP:0002058)3.58158996
26Lactic acidosis (HP:0003128)3.57354233
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56318797
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56318797
29Leukodystrophy (HP:0002415)3.54663494
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.54655392
31Increased serum lactate (HP:0002151)3.38721405
32Neuroendocrine neoplasm (HP:0100634)3.31541847
33Testicular atrophy (HP:0000029)3.30133615
34Muscle fiber inclusion bodies (HP:0100299)3.16044653
35Pheochromocytoma (HP:0002666)3.12026235
36Nemaline bodies (HP:0003798)3.08947553
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.08023633
38Increased muscle lipid content (HP:0009058)3.06562421
39Rhabdomyolysis (HP:0003201)3.01439373
40Exertional dyspnea (HP:0002875)2.99425784
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.97816642
42Progressive muscle weakness (HP:0003323)2.89864913
43Atonic seizures (HP:0010819)2.86881697
44Exercise-induced myalgia (HP:0003738)2.86188756
45Hypothermia (HP:0002045)2.85587494
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72883423
47Respiratory difficulties (HP:0002880)2.71528228
48Limb dystonia (HP:0002451)2.69100335
49Medial flaring of the eyebrow (HP:0010747)2.68834506
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68191175
51Abnormality of cells of the erythroid lineage (HP:0012130)2.67504822
52Myoglobinuria (HP:0002913)2.63171030
53Emotional lability (HP:0000712)2.62488176
54Abnormality of renal resorption (HP:0011038)2.61757958
55Bulbar palsy (HP:0001283)2.57295964
56CNS demyelination (HP:0007305)2.56843659
57Gait imbalance (HP:0002141)2.56204959
58Absence seizures (HP:0002121)2.56163372
59Abnormal hair whorl (HP:0010721)2.56085557
60Achilles tendon contracture (HP:0001771)2.53474375
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47583668
62Congenital primary aphakia (HP:0007707)2.47272271
63Type 1 muscle fiber predominance (HP:0003803)2.46233575
64X-linked dominant inheritance (HP:0001423)2.45146534
65Dialeptic seizures (HP:0011146)2.43560524
66Microretrognathia (HP:0000308)2.39964716
67Nephrogenic diabetes insipidus (HP:0009806)2.32848229
68Delusions (HP:0000746)2.31479671
69Abnormal number of erythroid precursors (HP:0012131)2.31181699
70Dicarboxylic aciduria (HP:0003215)2.29493698
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29493698
72Abnormality of the Achilles tendon (HP:0005109)2.29484033
73Prolonged neonatal jaundice (HP:0006579)2.26337897
74Muscle stiffness (HP:0003552)2.25984097
75Stridor (HP:0010307)2.24895751
76Epileptic encephalopathy (HP:0200134)2.24154994
77Hyperthyroidism (HP:0000836)2.23863248
78Abnormal pupillary function (HP:0007686)2.23098061
79Visual hallucinations (HP:0002367)2.22725173
80Cerebral palsy (HP:0100021)2.21954843
81Cerebral hypomyelination (HP:0006808)2.21793686
82Axonal loss (HP:0003447)2.20317519
83Vertebral compression fractures (HP:0002953)2.19636800
84EMG: myopathic abnormalities (HP:0003458)2.18395042
85Focal seizures (HP:0007359)2.18301560
86Poor suck (HP:0002033)2.17838829
87Sensory axonal neuropathy (HP:0003390)2.14481946
88Genital tract atresia (HP:0001827)2.13018713
89Vaginal atresia (HP:0000148)2.11035090
90Parakeratosis (HP:0001036)2.08837063
91Distal lower limb amyotrophy (HP:0008944)2.07909510
92Increased connective tissue (HP:0009025)2.07133798
93Febrile seizures (HP:0002373)2.06583239
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05989645
95Abnormality of alanine metabolism (HP:0010916)2.05989645
96Hyperalaninemia (HP:0003348)2.05989645
97Progressive microcephaly (HP:0000253)2.05361771
98Hyporeflexia of lower limbs (HP:0002600)2.04290587
99Retinal dysplasia (HP:0007973)2.01592336
100Abnormal atrioventricular conduction (HP:0005150)2.00292362
101Generalized tonic-clonic seizures (HP:0002069)1.97240132
102Athetosis (HP:0002305)1.96744373
103Progressive inability to walk (HP:0002505)1.95830656
104Hyperphosphaturia (HP:0003109)1.95077974
105Neck muscle weakness (HP:0000467)1.94241781
106Abnormality of glycolipid metabolism (HP:0010969)1.93477235
107Abnormality of liposaccharide metabolism (HP:0010968)1.93477235
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.93477235
109Hyperventilation (HP:0002883)1.91377510
110Generalized aminoaciduria (HP:0002909)1.91156614
111Opisthotonus (HP:0002179)1.90599451
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90588403
113Fasciculations (HP:0002380)1.90178539
114Ankle clonus (HP:0011448)1.88677293
115Asymmetric septal hypertrophy (HP:0001670)1.88272727
116Bundle branch block (HP:0011710)1.87139258
117Hypokinesia (HP:0002375)1.85703942
118Abnormality of the tricuspid valve (HP:0001702)1.85497428
119Foot dorsiflexor weakness (HP:0009027)1.84309408
120Sudden death (HP:0001699)1.84131344
121Lethargy (HP:0001254)1.83720315
122Heart block (HP:0012722)1.83504523
123Methylmalonic acidemia (HP:0002912)1.82638034
124Multiple enchondromatosis (HP:0005701)1.81208708
125Abnormality of fatty-acid metabolism (HP:0004359)1.80668505
126Abnormality of skeletal muscle fiber size (HP:0012084)1.80055346
127Type I transferrin isoform profile (HP:0003642)1.79952270
128Glycosuria (HP:0003076)1.79689776
129Abnormality of urine glucose concentration (HP:0011016)1.79689776
130J-shaped sella turcica (HP:0002680)1.79622801
131Esotropia (HP:0000565)1.79008956
132Cerebral hemorrhage (HP:0001342)1.78898698
133Anxiety (HP:0000739)1.78675003
134Unsteady gait (HP:0002317)1.77584591
135Methylmalonic aciduria (HP:0012120)1.77376725
136Microvesicular hepatic steatosis (HP:0001414)1.77198495
137Abnormality of lateral ventricle (HP:0030047)1.76776572
138Growth hormone excess (HP:0000845)1.75271368
139Muscle fiber splitting (HP:0003555)1.74889795
140Polyphagia (HP:0002591)1.74806847
141Broad-based gait (HP:0002136)1.74176960
142Truncus arteriosus (HP:0001660)1.72890833
143Hypertensive crisis (HP:0100735)1.70965428
144Blindness (HP:0000618)1.70698763
145Gliosis (HP:0002171)1.67404904
146Macrocytic anemia (HP:0001972)1.65524209
147Muscle hypertrophy of the lower extremities (HP:0008968)1.64617096
148Cholecystitis (HP:0001082)1.63238649
149Abnormal gallbladder physiology (HP:0012438)1.63238649
150Poor coordination (HP:0002370)1.61294715
151Renal tubular dysfunction (HP:0000124)1.59231722
152Inability to walk (HP:0002540)1.58699345
153CNS hypomyelination (HP:0003429)1.57486372
154Congenital ichthyosiform erythroderma (HP:0007431)1.56496862
155Abnormal respiratory motile cilium morphology (HP:0005938)1.55802852
156Abnormal respiratory epithelium morphology (HP:0012253)1.55802852
157Abnormal urine phosphate concentration (HP:0012599)1.54023201
158Calf muscle hypertrophy (HP:0008981)1.51198583
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.49364072
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.49364072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.02301176
2TRIB33.32627175
3TESK13.31502161
4VRK23.14745400
5STK163.04158068
6CASK2.97224637
7NME12.90880706
8ARAF2.90506512
9MAP3K112.83678015
10BCKDK2.77903063
11NTRK32.32276462
12MAP2K72.30329110
13STK392.25556363
14IRAK32.24055356
15GRK52.21322576
16SMG12.03714238
17TNIK2.02832365
18KDR1.93129954
19MYLK1.89412562
20CDK191.88082076
21EPHA41.86805342
22PNCK1.85494310
23SIK11.84735392
24MAPKAPK31.83542655
25OXSR11.79515994
26SCYL21.77652611
27MUSK1.75879123
28TTN1.75606973
29ERN11.73817412
30VRK11.71802354
31NME21.68914437
32PLK21.66867011
33LIMK11.64566018
34MAPKAPK51.61632462
35GRK71.58158940
36MAP3K41.57365817
37BCR1.53654441
38MST41.53345362
39PRKD31.51412388
40MAPK131.45754078
41TAOK21.39427012
42EIF2AK31.37745686
43MINK11.37184577
44BUB11.34695166
45WNK41.32975577
46PBK1.31094960
47BRAF1.25569197
48ADRBK21.24348738
49EPHA21.21458531
50CAMK2B1.21177873
51CCNB11.17823983
52BMPR21.17138757
53MARK11.16553503
54EIF2AK11.15793008
55LRRK21.15715834
56TSSK61.11941833
57BMPR1B1.11215511
58CSNK1G31.09688007
59CAMK2A1.07268213
60PIM21.04045002
61TBK11.03417528
62CAMK2D0.99096190
63UHMK10.96556155
64TESK20.93872541
65CAMKK20.90182692
66TAOK10.89939939
67MAP2K40.89467577
68CDK140.87955392
69PRKCI0.86210352
70CAMK2G0.86160538
71ICK0.84922096
72ABL20.84917364
73RIPK40.84727694
74DAPK10.84627144
75SRPK10.83232051
76PKN20.82668042
77PAK60.82614702
78CDK180.81838421
79CAMKK10.81629682
80ADRBK10.80730210
81PRKCG0.80706877
82PRPF4B0.79918732
83OBSCN0.79688025
84CSNK1G20.78865276
85DYRK20.78314485
86FES0.78069525
87TLK10.77941868
88MAP2K30.77383486
89RPS6KB20.77176317
90CDK80.76158995
91CDK150.75463195
92MAPK120.74699418
93PRKCE0.71388646
94CDK11A0.71359930
95PAK40.70554200
96PTK2B0.70479110
97CDK50.67724357
98PRKD20.67461476
99WNK30.66856210
100NTRK20.66012701
101EEF2K0.65034331
102MAP2K20.64624308
103AURKA0.62488026
104AKT20.62020602
105PAK10.61768610
106PHKG20.60082602
107PHKG10.60082602
108PDPK10.59146240
109CSNK1G10.58253570
110AKT30.58080858
111RPS6KA50.57582814
112SIK30.57488492
113PRKACA0.56166556
114STK240.54871834
115PLK30.54522857
116WEE10.53672695
117MAP3K10.53166310
118ROCK20.53060914
119BRSK10.52160275
120PRKD10.52044224
121RAF10.51818608
122FGR0.50738490
123CAMK10.50160299
124MAP3K90.50075005
125RPS6KA20.49602415
126RIPK10.48825832
127IRAK20.48486714
128DYRK1B0.48421690
129GRK60.46861498
130STK40.44901576
131DYRK1A0.42837837
132PRKG20.42485954
133LMTK20.41165209
134RPS6KL10.40341750
135RPS6KC10.40341750
136MAPK40.40303798
137NEK60.39739749
138MAP2K60.39195344
139DAPK30.39079104
140MARK20.38439774
141MAP4K10.38348482
142CSNK2A20.37820320
143NTRK10.37793534
144PDK20.37752752
145PINK10.37488195
146DMPK0.37304922
147ILK0.36673339
148DAPK20.36599665
149CSNK1A1L0.36324212
150CSNK2A10.36173181
151PDK30.35436125
152PDK40.35436125
153TNK20.35391611
154MAP3K30.34916111
155SGK2230.33343376
156PKN10.32845052
157MOS0.30383767
158MAP3K80.29242433
159IKBKB0.28645096

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.30816133
2Parkinsons disease_Homo sapiens_hsa050125.36538984
3Alzheimers disease_Homo sapiens_hsa050104.08639638
4Huntingtons disease_Homo sapiens_hsa050163.77609701
5Sulfur relay system_Homo sapiens_hsa041223.68021695
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31133413
7Proteasome_Homo sapiens_hsa030503.27195207
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.13062312
9Ribosome_Homo sapiens_hsa030103.09695643
10Cardiac muscle contraction_Homo sapiens_hsa042602.73449599
11Collecting duct acid secretion_Homo sapiens_hsa049662.68493276
12Protein export_Homo sapiens_hsa030602.58495203
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50698894
14RNA polymerase_Homo sapiens_hsa030202.36154398
15Nicotine addiction_Homo sapiens_hsa050332.21484678
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05884736
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87167862
18Biosynthesis of amino acids_Homo sapiens_hsa012301.87152045
19Fructose and mannose metabolism_Homo sapiens_hsa000511.80936131
20Pentose phosphate pathway_Homo sapiens_hsa000301.67943993
21Vibrio cholerae infection_Homo sapiens_hsa051101.67449472
22Base excision repair_Homo sapiens_hsa034101.61109241
23Arginine and proline metabolism_Homo sapiens_hsa003301.53295946
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47973156
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43809182
26Fatty acid elongation_Homo sapiens_hsa000621.43732257
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43334117
28Phototransduction_Homo sapiens_hsa047441.39859280
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.33730615
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30678829
31Serotonergic synapse_Homo sapiens_hsa047261.28506626
32Other glycan degradation_Homo sapiens_hsa005111.27293811
33GABAergic synapse_Homo sapiens_hsa047271.27059601
34Pyrimidine metabolism_Homo sapiens_hsa002401.15638743
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14052052
36Galactose metabolism_Homo sapiens_hsa000521.13325830
37Morphine addiction_Homo sapiens_hsa050321.12292766
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11974383
39Olfactory transduction_Homo sapiens_hsa047401.11192655
40Taste transduction_Homo sapiens_hsa047421.09547846
41Amphetamine addiction_Homo sapiens_hsa050311.07857563
42Pyruvate metabolism_Homo sapiens_hsa006201.05948745
43Arginine biosynthesis_Homo sapiens_hsa002201.05918294
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01959754
45Dopaminergic synapse_Homo sapiens_hsa047280.99037840
46Glutamatergic synapse_Homo sapiens_hsa047240.97668049
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97286553
48Circadian entrainment_Homo sapiens_hsa047130.97149031
49Sulfur metabolism_Homo sapiens_hsa009200.94872807
50Rheumatoid arthritis_Homo sapiens_hsa053230.92384576
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.90664030
52Prion diseases_Homo sapiens_hsa050200.88840787
53Purine metabolism_Homo sapiens_hsa002300.84726249
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82104838
55Fatty acid metabolism_Homo sapiens_hsa012120.81492463
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80300346
57Metabolic pathways_Homo sapiens_hsa011000.77929827
58Long-term potentiation_Homo sapiens_hsa047200.77075934
59Fatty acid degradation_Homo sapiens_hsa000710.76776705
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75049937
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74578859
62Lysosome_Homo sapiens_hsa041420.71371219
63Regulation of autophagy_Homo sapiens_hsa041400.71126391
64Basal transcription factors_Homo sapiens_hsa030220.70405745
65Cocaine addiction_Homo sapiens_hsa050300.69430083
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66737983
67Long-term depression_Homo sapiens_hsa047300.64667564
68Steroid biosynthesis_Homo sapiens_hsa001000.64498990
69Ether lipid metabolism_Homo sapiens_hsa005650.64469373
70Calcium signaling pathway_Homo sapiens_hsa040200.62130142
71Spliceosome_Homo sapiens_hsa030400.59722538
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57766034
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57496289
74Nucleotide excision repair_Homo sapiens_hsa034200.55312631
75Renin secretion_Homo sapiens_hsa049240.55255171
76Salivary secretion_Homo sapiens_hsa049700.54398688
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53892924
78Cholinergic synapse_Homo sapiens_hsa047250.53317616
79Insulin secretion_Homo sapiens_hsa049110.53045041
80Phagosome_Homo sapiens_hsa041450.52874379
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51800562
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50891328
83Propanoate metabolism_Homo sapiens_hsa006400.48230952
84Insulin signaling pathway_Homo sapiens_hsa049100.46252946
85Systemic lupus erythematosus_Homo sapiens_hsa053220.43625500
86Butanoate metabolism_Homo sapiens_hsa006500.43338861
87Dilated cardiomyopathy_Homo sapiens_hsa054140.42910521
88Tyrosine metabolism_Homo sapiens_hsa003500.42849292
89Vitamin B6 metabolism_Homo sapiens_hsa007500.40178720
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39380435
91Linoleic acid metabolism_Homo sapiens_hsa005910.39105671
92AMPK signaling pathway_Homo sapiens_hsa041520.38216906
93Phenylalanine metabolism_Homo sapiens_hsa003600.38200299
94Alcoholism_Homo sapiens_hsa050340.37935347
95Salmonella infection_Homo sapiens_hsa051320.37165895
96VEGF signaling pathway_Homo sapiens_hsa043700.36919051
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36392020
98PPAR signaling pathway_Homo sapiens_hsa033200.35726097
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35238390
100beta-Alanine metabolism_Homo sapiens_hsa004100.33726924
101Carbon metabolism_Homo sapiens_hsa012000.33003944
102Homologous recombination_Homo sapiens_hsa034400.31879649
103Type I diabetes mellitus_Homo sapiens_hsa049400.31847019
104RNA degradation_Homo sapiens_hsa030180.31198560
105Glutathione metabolism_Homo sapiens_hsa004800.30778036
106Bladder cancer_Homo sapiens_hsa052190.30606047
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.30454493
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29907754
109Sphingolipid metabolism_Homo sapiens_hsa006000.29572298
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29054068
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.28034497
112Oxytocin signaling pathway_Homo sapiens_hsa049210.27708500
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.26589600
114N-Glycan biosynthesis_Homo sapiens_hsa005100.26456745
115Fatty acid biosynthesis_Homo sapiens_hsa000610.26269462
116Gastric acid secretion_Homo sapiens_hsa049710.25588891
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25517510
118Non-homologous end-joining_Homo sapiens_hsa034500.24926006
119Endocytosis_Homo sapiens_hsa041440.24270556
120Oocyte meiosis_Homo sapiens_hsa041140.22718794
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22559299
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22521521
123Gap junction_Homo sapiens_hsa045400.21644938
124Epstein-Barr virus infection_Homo sapiens_hsa051690.20417634
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.19639046
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18866116
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.18260567
128Shigellosis_Homo sapiens_hsa051310.18255899
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18073523
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17741297
131Glucagon signaling pathway_Homo sapiens_hsa049220.17492100
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16136675
133Mismatch repair_Homo sapiens_hsa034300.15961371
134Folate biosynthesis_Homo sapiens_hsa007900.15885713
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14576657
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14407565
137Graft-versus-host disease_Homo sapiens_hsa053320.13968542
138RNA transport_Homo sapiens_hsa030130.13886117
139DNA replication_Homo sapiens_hsa030300.13001753
140Autoimmune thyroid disease_Homo sapiens_hsa053200.12829171
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12745801
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12182617
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10974490
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10648928
145Axon guidance_Homo sapiens_hsa043600.10511359
146Peroxisome_Homo sapiens_hsa041460.10308076
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08548166
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05105422
149Tryptophan metabolism_Homo sapiens_hsa003800.04812959
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02324158

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