MRPL42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.23386152
2oxidative phosphorylation (GO:0006119)5.21719223
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.09813782
4DNA deamination (GO:0045006)4.86209722
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.59882762
6ATP synthesis coupled proton transport (GO:0015986)4.59882762
7telomere maintenance via semi-conservative replication (GO:0032201)4.25053311
8proteasome assembly (GO:0043248)4.24740148
9tricarboxylic acid cycle (GO:0006099)4.21481398
10regulation of mitochondrial translation (GO:0070129)4.11880302
11respiratory electron transport chain (GO:0022904)4.07006917
12DNA strand elongation involved in DNA replication (GO:0006271)4.02320298
13DNA double-strand break processing (GO:0000729)4.01631329
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96099171
15electron transport chain (GO:0022900)3.95841046
16formation of translation preinitiation complex (GO:0001731)3.95360851
17maturation of SSU-rRNA (GO:0030490)3.92762045
18purine nucleobase biosynthetic process (GO:0009113)3.88855608
19DNA strand elongation (GO:0022616)3.83695103
20nucleobase biosynthetic process (GO:0046112)3.82900420
21telomere maintenance via recombination (GO:0000722)3.81648434
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72515128
23ribosomal large subunit biogenesis (GO:0042273)3.71653498
24water-soluble vitamin biosynthetic process (GO:0042364)3.59868298
25regulation of mitotic spindle checkpoint (GO:1903504)3.58827064
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58827064
27CENP-A containing nucleosome assembly (GO:0034080)3.58524591
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58156944
29rRNA modification (GO:0000154)3.55194622
30DNA replication initiation (GO:0006270)3.53417856
31IMP biosynthetic process (GO:0006188)3.51782915
32chromatin remodeling at centromere (GO:0031055)3.51239722
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47110974
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.47110974
35NADH dehydrogenase complex assembly (GO:0010257)3.47110974
36mitotic recombination (GO:0006312)3.45145286
37cullin deneddylation (GO:0010388)3.44165453
38DNA replication checkpoint (GO:0000076)3.43429931
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42107869
40protein complex biogenesis (GO:0070271)3.41408656
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41377583
42respiratory chain complex IV assembly (GO:0008535)3.41338366
43heart process (GO:0003015)3.40613617
44heart contraction (GO:0060047)3.40613617
45replication fork processing (GO:0031297)3.39613624
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38864879
47pseudouridine synthesis (GO:0001522)3.38358735
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.37394023
49viral transcription (GO:0019083)3.36290582
50mitochondrial respiratory chain complex assembly (GO:0033108)3.35186402
51ribonucleoprotein complex biogenesis (GO:0022613)3.34126772
52mitotic metaphase plate congression (GO:0007080)3.32981554
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32816793
54translational termination (GO:0006415)3.32337474
55protein deneddylation (GO:0000338)3.32187656
56telomere maintenance via telomere lengthening (GO:0010833)3.31728436
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30980206
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30518087
59ribosome biogenesis (GO:0042254)3.30332514
60translational elongation (GO:0006414)3.26858262
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.23472719
62IMP metabolic process (GO:0046040)3.23394210
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22685591
64regulation of cellular amino acid metabolic process (GO:0006521)3.22509232
65aerobic respiration (GO:0009060)3.21810472
66spliceosomal snRNP assembly (GO:0000387)3.21479465
67quinone biosynthetic process (GO:1901663)3.21130978
68ubiquinone biosynthetic process (GO:0006744)3.21130978
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.20144362
70somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20144362
71histone exchange (GO:0043486)3.18513758
72ribosomal small subunit biogenesis (GO:0042274)3.18381853
73negative regulation of ligase activity (GO:0051352)3.18229744
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18229744
75* translation (GO:0006412)3.17919277
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17739109
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17739109
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17084711
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17084711
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17084711
81kinetochore assembly (GO:0051382)3.15973062
82kinetochore organization (GO:0051383)3.15410588
83cellular component biogenesis (GO:0044085)3.14212100
84nucleobase-containing small molecule interconversion (GO:0015949)3.12748670
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.10137526
86termination of RNA polymerase III transcription (GO:0006386)3.10137526
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09825430
88signal transduction involved in DNA damage checkpoint (GO:0072422)3.09825430
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.07069371
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.05226268
91muscle filament sliding (GO:0030049)3.04650138
92actin-myosin filament sliding (GO:0033275)3.04650138
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04491595
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.04423971
95NADH metabolic process (GO:0006734)3.04020403
96translational initiation (GO:0006413)3.02800199
97transcription-coupled nucleotide-excision repair (GO:0006283)3.02276825
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01649240
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00820543
100rRNA processing (GO:0006364)2.97771385
101protein neddylation (GO:0045116)2.97153739
102sarcomere organization (GO:0045214)2.97051717
103ribosome assembly (GO:0042255)2.97020559
104DNA replication-independent nucleosome organization (GO:0034724)2.95428205
105DNA replication-independent nucleosome assembly (GO:0006336)2.95428205
106metallo-sulfur cluster assembly (GO:0031163)2.94625381
107iron-sulfur cluster assembly (GO:0016226)2.94625381
108cotranslational protein targeting to membrane (GO:0006613)2.93243000
109DNA damage response, detection of DNA damage (GO:0042769)2.93127246
110deoxyribonucleotide biosynthetic process (GO:0009263)2.92796113
111protein targeting to ER (GO:0045047)2.91729145
112cytochrome complex assembly (GO:0017004)2.91128846
113RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89582849
114deoxyribose phosphate biosynthetic process (GO:0046385)2.89150707
1152-deoxyribonucleotide biosynthetic process (GO:0009265)2.89150707
116metaphase plate congression (GO:0051310)2.89051817
117positive regulation of ligase activity (GO:0051351)2.88424755
118rRNA metabolic process (GO:0016072)2.85681973
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80718196
120behavioral response to nicotine (GO:0035095)2.80204237
121DNA replication-dependent nucleosome assembly (GO:0006335)2.76882041
122DNA replication-dependent nucleosome organization (GO:0034723)2.76882041
123recombinational repair (GO:0000725)2.76801001
124maturation of 5.8S rRNA (GO:0000460)2.76137150
125rRNA methylation (GO:0031167)2.76126471
126double-strand break repair via homologous recombination (GO:0000724)2.75924118
127histone mRNA metabolic process (GO:0008334)2.75403177
128response to pheromone (GO:0019236)2.74463534
129resolution of meiotic recombination intermediates (GO:0000712)2.70602816
130DNA catabolic process, exonucleolytic (GO:0000738)2.70401261
131negative regulation of DNA recombination (GO:0045910)2.68991866
132synapsis (GO:0007129)2.68481405
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67698375
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67698375
135histone H2A acetylation (GO:0043968)2.67344693
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62071938
137isotype switching (GO:0045190)2.62071938
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62071938
139nonmotile primary cilium assembly (GO:0035058)2.61099365
140peptidyl-histidine modification (GO:0018202)2.60416547
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.58656571
142regulation of translation, ncRNA-mediated (GO:0045974)2.58656571
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58656571
144regulation of centriole replication (GO:0046599)2.57549931
145postreplication repair (GO:0006301)2.55564753
146mitochondrial RNA metabolic process (GO:0000959)2.55260400
147chaperone-mediated protein transport (GO:0072321)2.54958205
148regulation of helicase activity (GO:0051095)2.53109603
149kidney morphogenesis (GO:0060993)2.52892161
150organelle disassembly (GO:1903008)2.51933601
151intraciliary transport (GO:0042073)2.49952459
152neural tube formation (GO:0001841)2.49668425
153spindle checkpoint (GO:0031577)2.48870521
154establishment of integrated proviral latency (GO:0075713)2.48380472
155prenylation (GO:0097354)2.47840952
156protein prenylation (GO:0018342)2.47840952
157signal peptide processing (GO:0006465)2.47813007
158reciprocal DNA recombination (GO:0035825)2.43758441
159reciprocal meiotic recombination (GO:0007131)2.43758441
160mitotic spindle checkpoint (GO:0071174)2.42337092
161protein K6-linked ubiquitination (GO:0085020)2.41449825
162attachment of spindle microtubules to kinetochore (GO:0008608)2.41078567
163double-strand break repair via nonhomologous end joining (GO:0006303)2.40062449
164non-recombinational repair (GO:0000726)2.40062449
165amino acid salvage (GO:0043102)2.39088452
166L-methionine salvage (GO:0071267)2.39088452
167L-methionine biosynthetic process (GO:0071265)2.39088452
168regulation of DNA endoreduplication (GO:0032875)2.36122936
169telomere maintenance via telomerase (GO:0007004)2.36100496
170protein-cofactor linkage (GO:0018065)2.35468375
171tRNA processing (GO:0008033)2.35034751
172cellular ketone body metabolic process (GO:0046950)2.34931125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17076839
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34047368
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26091648
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.18270210
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54768060
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.50334815
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.45611293
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.19623732
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13648550
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09953072
11ZNF274_21170338_ChIP-Seq_K562_Hela2.94548354
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88390520
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85846918
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85696132
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83065117
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.77640555
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76783853
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63034278
19VDR_22108803_ChIP-Seq_LS180_Human2.54694996
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54500766
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49600234
22FUS_26573619_Chip-Seq_HEK293_Human2.46632734
23EWS_26573619_Chip-Seq_HEK293_Human2.46396160
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45290992
25VDR_23849224_ChIP-Seq_CD4+_Human2.41182564
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38740477
27IGF1R_20145208_ChIP-Seq_DFB_Human2.38174509
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.37765027
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35407224
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33331210
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33191091
32DCP1A_22483619_ChIP-Seq_HELA_Human2.30292319
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.24196500
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23022942
35XRN2_22483619_ChIP-Seq_HELA_Human2.21953556
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20495271
37ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18130882
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14143502
39FOXP3_21729870_ChIP-Seq_TREG_Human2.12491399
40TAF15_26573619_Chip-Seq_HEK293_Human2.12057781
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.08728378
42GBX2_23144817_ChIP-Seq_PC3_Human2.08430244
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07474089
44YY1_21170310_ChIP-Seq_MESCs_Mouse2.02564304
45GABP_19822575_ChIP-Seq_HepG2_Human1.97107603
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87369353
47* P300_19829295_ChIP-Seq_ESCs_Human1.86540557
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83065315
49TTF2_22483619_ChIP-Seq_HELA_Human1.80808791
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79562262
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78456864
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77220781
53ELK1_19687146_ChIP-ChIP_HELA_Human1.75798262
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75534698
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75250122
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72691993
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70099657
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69679329
59AR_21909140_ChIP-Seq_LNCAP_Human1.69655855
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69171860
61* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68888098
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67794233
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67244317
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67099554
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64832908
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61071982
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60869276
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57955643
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57887000
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57530535
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55368227
72* E2F1_21310950_ChIP-Seq_MCF-7_Human1.52243012
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48817832
74CIITA_25753668_ChIP-Seq_RAJI_Human1.47612557
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46499098
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45442410
77IRF1_19129219_ChIP-ChIP_H3396_Human1.43264694
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40016337
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39937768
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39894708
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37476589
82ER_23166858_ChIP-Seq_MCF-7_Human1.35685002
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34266294
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31517726
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29265357
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28338201
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28235985
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27742102
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.26987848
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25819363
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24258012
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24254327
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.23522877
94KDM5A_27292631_Chip-Seq_BREAST_Human1.21962580
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21893263
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21638061
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.20271864
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18829013
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18783319
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17778122
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17144605
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.17032965
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16827454
104SMAD4_21799915_ChIP-Seq_A2780_Human1.15690262
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14958215
106CBP_20019798_ChIP-Seq_JUKART_Human1.14839401
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14839401
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13832273
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.12987467
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12608550
111TP53_22573176_ChIP-Seq_HFKS_Human1.11114895
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.11095365
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10659427
114* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10332361
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09552832
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09030974
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08457750
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07832308
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07675445
120STAT3_23295773_ChIP-Seq_U87_Human1.06775993
121SOX2_19829295_ChIP-Seq_ESCs_Human1.06528676
122NANOG_19829295_ChIP-Seq_ESCs_Human1.06528676
123BCAT_22108803_ChIP-Seq_LS180_Human1.05487214
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05032868
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04480279
126ELK1_22589737_ChIP-Seq_MCF10A_Human1.04143692
127TCF4_22108803_ChIP-Seq_LS180_Human1.03507269
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.03044007
129AR_25329375_ChIP-Seq_VCAP_Human1.02476205
130GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01004373
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00922585
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00887261
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.00427631
134MYC_18940864_ChIP-ChIP_HL60_Human0.99804308
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99557501
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99362175
137RNF2_27304074_Chip-Seq_NSC_Mouse0.97984905
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97816071
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97816071
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97430461
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97269486
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96358346
143TCF4_23295773_ChIP-Seq_U87_Human0.96172660
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95881788
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95525906
146TFEB_21752829_ChIP-Seq_HELA_Human0.95032078
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94442707
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93588806
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91178272
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90776519
151* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89371580
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88884194
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88423747
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87839641
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87771264
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82089717
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81360725
158* SPI1_23547873_ChIP-Seq_NB4_Human0.80548108
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80313329
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79977297
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79497218
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79389808
163SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76689489
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75081012
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.74218018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.49310485
2MP0003693_abnormal_embryo_hatching4.13168240
3MP0004084_abnormal_cardiac_muscle3.80374210
4MP0003806_abnormal_nucleotide_metabolis3.31664974
5MP0004957_abnormal_blastocyst_morpholog3.23335775
6MP0000749_muscle_degeneration3.15041014
7MP0006036_abnormal_mitochondrial_physio3.14464582
8MP0010094_abnormal_chromosome_stability3.11379792
9MP0002837_dystrophic_cardiac_calcinosis3.04065556
10MP0004215_abnormal_myocardial_fiber2.94417010
11MP0003077_abnormal_cell_cycle2.76471401
12MP0003111_abnormal_nucleus_morphology2.75919524
13MP0008058_abnormal_DNA_repair2.58221678
14MP0004036_abnormal_muscle_relaxation2.53267566
15MP0005330_cardiomyopathy2.51621089
16MP0003186_abnormal_redox_activity2.40828246
17MP0002102_abnormal_ear_morphology2.36941723
18MP0006072_abnormal_retinal_apoptosis2.17813882
19MP0003890_abnormal_embryonic-extraembry2.16826131
20MP0000751_myopathy2.13088286
21MP0006035_abnormal_mitochondrial_morpho2.11425950
22MP0008007_abnormal_cellular_replicative2.06886008
23MP0002938_white_spotting1.99170545
24MP0001529_abnormal_vocalization1.92648751
25MP0003195_calcinosis1.91071078
26MP0003221_abnormal_cardiomyocyte_apopto1.90642721
27MP0000750_abnormal_muscle_regeneration1.89373415
28MP0008775_abnormal_heart_ventricle1.86570408
29MP0003123_paternal_imprinting1.85619801
30MP0003880_abnormal_central_pattern1.80720464
31MP0003567_abnormal_fetal_cardiomyocyte1.78685059
32MP0008932_abnormal_embryonic_tissue1.78123929
33MP0008057_abnormal_DNA_replication1.78058902
34MP0004147_increased_porphyrin_level1.77553453
35MP0003787_abnormal_imprinting1.77372735
36MP0002972_abnormal_cardiac_muscle1.77356670
37MP0004133_heterotaxia1.76494198
38MP0003136_yellow_coat_color1.73536308
39MP0002396_abnormal_hematopoietic_system1.73100147
40MP0002269_muscular_atrophy1.73063628
41MP0004087_abnormal_muscle_fiber1.71074842
42MP0001293_anophthalmia1.70347564
43MP0001544_abnormal_cardiovascular_syste1.64802231
44MP0005385_cardiovascular_system_phenoty1.64802231
45MP0003121_genomic_imprinting1.59869773
46MP0005551_abnormal_eye_electrophysiolog1.59646529
47MP0005253_abnormal_eye_physiology1.59551000
48MP0001984_abnormal_olfaction1.59366072
49MP0002106_abnormal_muscle_physiology1.52034609
50MP0009697_abnormal_copulation1.51907857
51MP0003137_abnormal_impulse_conducting1.50713905
52MP0000631_abnormal_neuroendocrine_gland1.50186894
53MP0001485_abnormal_pinna_reflex1.49802435
54MP0010630_abnormal_cardiac_muscle1.49029181
55MP0005620_abnormal_muscle_contractility1.46071709
56MP0003937_abnormal_limbs/digits/tail_de1.44859513
57MP0008877_abnormal_DNA_methylation1.43643641
58MP0002736_abnormal_nociception_after1.42900737
59MP0008789_abnormal_olfactory_epithelium1.39816835
60MP0001730_embryonic_growth_arrest1.38633210
61MP0003786_premature_aging1.38390732
62MP0002751_abnormal_autonomic_nervous1.37223497
63MP0009046_muscle_twitch1.35965964
64MP0006276_abnormal_autonomic_nervous1.35318675
65MP0002234_abnormal_pharynx_morphology1.33936633
66MP0001853_heart_inflammation1.32578276
67MP0008995_early_reproductive_senescence1.32542331
68MP0003119_abnormal_digestive_system1.32441933
69MP0003122_maternal_imprinting1.32235747
70MP0003718_maternal_effect1.31712896
71MP0005266_abnormal_metabolism1.30629535
72MP0003828_pulmonary_edema1.28907164
73MP0000569_abnormal_digit_pigmentation1.27854865
74MP0004484_altered_response_of1.26000009
75MP0005645_abnormal_hypothalamus_physiol1.25826737
76MP0001764_abnormal_homeostasis1.25522122
77MP0004145_abnormal_muscle_electrophysio1.22505518
78MP0001968_abnormal_touch/_nociception1.21246418
79MP0000490_abnormal_crypts_of1.21164596
80MP0006138_congestive_heart_failure1.20182887
81MP0001188_hyperpigmentation1.19610675
82MP0003011_delayed_dark_adaptation1.15348013
83MP0005369_muscle_phenotype1.15300961
84MP0003984_embryonic_growth_retardation1.13763169
85MP0002132_abnormal_respiratory_system1.13209869
86MP0002127_abnormal_cardiovascular_syste1.12739948
87MP0000350_abnormal_cell_proliferation1.11212995
88MP0002163_abnormal_gland_morphology1.10068758
89MP0000313_abnormal_cell_death1.09921699
90MP0002088_abnormal_embryonic_growth/wei1.09846276
91MP0005380_embryogenesis_phenotype1.09379595
92MP0001672_abnormal_embryogenesis/_devel1.09379595
93MP0009379_abnormal_foot_pigmentation1.09267950
94MP0005394_taste/olfaction_phenotype1.09066798
95MP0005499_abnormal_olfactory_system1.09066798
96MP0000343_altered_response_to1.08649901
97MP0002233_abnormal_nose_morphology1.08148312
98MP0000358_abnormal_cell_content/1.07664100
99MP0000759_abnormal_skeletal_muscle1.06820544
100MP0001286_abnormal_eye_development1.05683652
101MP0000427_abnormal_hair_cycle1.05366542
102MP0002272_abnormal_nervous_system1.04847054
103MP0005379_endocrine/exocrine_gland_phen1.04582959
104MP0001697_abnormal_embryo_size1.04021658
105MP0009745_abnormal_behavioral_response1.03937925
106MP0000647_abnormal_sebaceous_gland1.02487498
107MP0001929_abnormal_gametogenesis1.00742318
108MP0001486_abnormal_startle_reflex1.00159386
109MP0004233_abnormal_muscle_weight0.99306859
110MP0008872_abnormal_physiological_respon0.98273141
111MP0002080_prenatal_lethality0.96445240
112MP0005646_abnormal_pituitary_gland0.96192189
113MP0000778_abnormal_nervous_system0.96127540
114MP0005391_vision/eye_phenotype0.95071256
115MP0004142_abnormal_muscle_tone0.94407878
116MP0002332_abnormal_exercise_endurance0.92949702
117MP0000747_muscle_weakness0.91525209
118MP0005670_abnormal_white_adipose0.91003683
119MP0000653_abnormal_sex_gland0.89300364
120MP0003283_abnormal_digestive_organ0.89167668
121MP0005367_renal/urinary_system_phenotyp0.88474772
122MP0000516_abnormal_urinary_system0.88474772
123MP0009333_abnormal_splenocyte_physiolog0.88344859
124MP0005319_abnormal_enzyme/_coenzyme0.88237290
125MP0002557_abnormal_social/conspecific_i0.87092696
126MP0005195_abnormal_posterior_eye0.86169966
127MP0005187_abnormal_penis_morphology0.86134669
128MP0002090_abnormal_vision0.86016595
129MP0001145_abnormal_male_reproductive0.85909010
130MP0002019_abnormal_tumor_incidence0.85321211
131MP0002184_abnormal_innervation0.85045536
132MP0002734_abnormal_mechanical_nocicepti0.83929439
133MP0003698_abnormal_male_reproductive0.83742003
134MP0002084_abnormal_developmental_patter0.81393789
135MP0003941_abnormal_skin_development0.81065520
136MP0000383_abnormal_hair_follicle0.80843648
137MP0003656_abnormal_erythrocyte_physiolo0.80774574
138MP0000049_abnormal_middle_ear0.79702079
139MP0002752_abnormal_somatic_nervous0.79259732
140MP0004808_abnormal_hematopoietic_stem0.79089427
141MP0006054_spinal_hemorrhage0.78958324
142MP0005389_reproductive_system_phenotype0.78945424
143MP0001324_abnormal_eye_pigmentation0.73911382
144MP0004130_abnormal_muscle_cell0.73334538
145MP0005395_other_phenotype0.73247200
146MP0000266_abnormal_heart_morphology0.72403330
147MP0003755_abnormal_palate_morphology0.72160894
148MP0003861_abnormal_nervous_system0.71365596
149MP0001177_atelectasis0.70632228
150MP0004924_abnormal_behavior0.70507255
151MP0004085_abnormal_heartbeat0.66932081
152MP0005165_increased_susceptibility_to0.66045976
153MP0005332_abnormal_amino_acid0.65869888
154MP0005376_homeostasis/metabolism_phenot0.65710661
155MP0003763_abnormal_thymus_physiology0.62866485
156MP0001545_abnormal_hematopoietic_system0.62631970
157MP0005397_hematopoietic_system_phenotyp0.62631970
158MP0002160_abnormal_reproductive_system0.62322833
159MP0003315_abnormal_perineum_morphology0.61912170
160MP0002086_abnormal_extraembryonic_tissu0.61703416
161MP0010352_gastrointestinal_tract_polyps0.60466889
162MP0001835_abnormal_antigen_presentation0.55957461
163MP0002722_abnormal_immune_system0.55001675
164MP0000689_abnormal_spleen_morphology0.53114467
165MP0000858_altered_metastatic_potential0.53100005
166MP0006292_abnormal_olfactory_placode0.53035217
167MP0001119_abnormal_female_reproductive0.53009752
168MP0002210_abnormal_sex_determination0.52919198
169MP0002085_abnormal_embryonic_tissue0.51947004
170MP0002638_abnormal_pupillary_reflex0.51791370
171MP0005084_abnormal_gallbladder_morpholo0.50082306
172MP0000372_irregular_coat_pigmentation0.48535268

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)5.03317229
2Acute necrotizing encephalopathy (HP:0006965)5.00018363
3Abnormal mitochondria in muscle tissue (HP:0008316)4.93973062
4Hepatocellular necrosis (HP:0001404)4.85058200
5Mitochondrial inheritance (HP:0001427)4.69147694
6Increased CSF lactate (HP:0002490)4.63018499
7Acute encephalopathy (HP:0006846)4.29840221
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.09186544
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.09186544
10Progressive macrocephaly (HP:0004481)4.00879276
11Increased serum lactate (HP:0002151)3.88067186
12Lactic acidosis (HP:0003128)3.67204735
13Exercise intolerance (HP:0003546)3.64907768
14Exercise-induced muscle cramps (HP:0003710)3.49894694
15Cerebral edema (HP:0002181)3.47790784
16Ventricular tachycardia (HP:0004756)3.46329475
17Pancreatic cysts (HP:0001737)3.45556569
18Lipid accumulation in hepatocytes (HP:0006561)3.45149196
19Abnormal number of erythroid precursors (HP:0012131)3.44588934
20Rhabdomyolysis (HP:0003201)3.42560003
21Increased hepatocellular lipid droplets (HP:0006565)3.41788621
22Abnormality of cells of the erythroid lineage (HP:0012130)3.39565986
23Increased intramyocellular lipid droplets (HP:0012240)3.37818287
24Increased serum pyruvate (HP:0003542)3.34207806
25Abnormality of glycolysis (HP:0004366)3.34207806
26Increased muscle lipid content (HP:0009058)3.31263597
27Palpitations (HP:0001962)3.25817469
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25310106
29Abnormality of alanine metabolism (HP:0010916)3.25310106
30Hyperalaninemia (HP:0003348)3.25310106
31Abnormality of the labia minora (HP:0012880)3.25169875
32Myoglobinuria (HP:0002913)3.25021845
33Respiratory failure (HP:0002878)3.24969436
34Pancreatic fibrosis (HP:0100732)3.22204359
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20456821
36Nausea (HP:0002018)3.16476931
37Oral leukoplakia (HP:0002745)3.08720127
38Birth length less than 3rd percentile (HP:0003561)3.06184092
39Sudden death (HP:0001699)3.05778623
40Reticulocytopenia (HP:0001896)2.99513701
41True hermaphroditism (HP:0010459)2.99154333
42Microvesicular hepatic steatosis (HP:0001414)2.90515328
43Calf muscle hypertrophy (HP:0008981)2.89962907
44Lipoatrophy (HP:0100578)2.89818649
45Abnormality of midbrain morphology (HP:0002418)2.86680045
46Molar tooth sign on MRI (HP:0002419)2.86680045
47Nephronophthisis (HP:0000090)2.81312749
48Medial flaring of the eyebrow (HP:0010747)2.79429492
49Dicarboxylic aciduria (HP:0003215)2.76827529
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76827529
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73163624
52Generalized aminoaciduria (HP:0002909)2.73032012
53Multiple enchondromatosis (HP:0005701)2.66272834
54Exercise-induced myalgia (HP:0003738)2.63648408
55Aplastic anemia (HP:0001915)2.61501141
56Methylmalonic acidemia (HP:0002912)2.61089550
57Respiratory difficulties (HP:0002880)2.57663458
58Atrial fibrillation (HP:0005110)2.57582118
59Muscle hypertrophy of the lower extremities (HP:0008968)2.55741230
60Ragged-red muscle fibers (HP:0003200)2.54085957
61Meckel diverticulum (HP:0002245)2.52811623
62Supraventricular tachycardia (HP:0004755)2.52242648
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.51890052
64Dilated cardiomyopathy (HP:0001644)2.51121338
65Exertional dyspnea (HP:0002875)2.51106468
66CNS demyelination (HP:0007305)2.50950061
67Abnormality of the ileum (HP:0001549)2.49122557
68Intestinal atresia (HP:0011100)2.47104035
693-Methylglutaconic aciduria (HP:0003535)2.44345262
70Supraventricular arrhythmia (HP:0005115)2.41705135
71Subaortic stenosis (HP:0001682)2.41116076
72Abnormality of the left ventricular outflow tract (HP:0011103)2.41116076
73Lethargy (HP:0001254)2.37377579
74Primary atrial arrhythmia (HP:0001692)2.36492578
75Proximal tubulopathy (HP:0000114)2.35878144
76Abnormality of chromosome stability (HP:0003220)2.35157691
77Abnormality of fatty-acid metabolism (HP:0004359)2.34907100
78Congenital primary aphakia (HP:0007707)2.34674086
79Abnormality of the renal medulla (HP:0100957)2.33350481
80Gait imbalance (HP:0002141)2.32802205
81Volvulus (HP:0002580)2.31531896
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30181403
83Renal Fanconi syndrome (HP:0001994)2.27710387
84Hypoglycemic coma (HP:0001325)2.26581172
85Genital tract atresia (HP:0001827)2.21518909
86Abnormality of the pons (HP:0007361)2.21368037
87Nephrogenic diabetes insipidus (HP:0009806)2.17097351
88Vaginal atresia (HP:0000148)2.16500250
89Hypoplasia of the pons (HP:0012110)2.16162159
90Progressive muscle weakness (HP:0003323)2.15687664
91Abnormality of the anterior horn cell (HP:0006802)2.15509208
92Degeneration of anterior horn cells (HP:0002398)2.15509208
93Type I transferrin isoform profile (HP:0003642)2.12675123
94Neoplasm of the adrenal gland (HP:0100631)2.12147541
95Glycosuria (HP:0003076)2.11889167
96Abnormality of urine glucose concentration (HP:0011016)2.11889167
97Hypothermia (HP:0002045)2.09457386
98Conjunctival hamartoma (HP:0100780)2.08892005
99Areflexia of lower limbs (HP:0002522)2.08440452
100Abnormality of the renal cortex (HP:0011035)2.08213865
101Abolished electroretinogram (ERG) (HP:0000550)2.07943988
102Methylmalonic aciduria (HP:0012120)2.06635492
103Abnormality of the calf musculature (HP:0001430)2.05841138
104Colon cancer (HP:0003003)2.05790665
105Hyperglycinemia (HP:0002154)2.05432528
106Rough bone trabeculation (HP:0100670)2.04492222
107Sclerocornea (HP:0000647)2.03456675
108Breast hypoplasia (HP:0003187)2.03246708
109Pendular nystagmus (HP:0012043)2.02318113
110Emotional lability (HP:0000712)2.01427578
111Abnormality of serum amino acid levels (HP:0003112)2.01400975
112Macrocytic anemia (HP:0001972)2.00693055
113Congenital stationary night blindness (HP:0007642)2.00245477
114Congenital, generalized hypertrichosis (HP:0004540)1.99439451
115Optic disc pallor (HP:0000543)1.98199828
116Type 2 muscle fiber atrophy (HP:0003554)1.98006664
117Sloping forehead (HP:0000340)1.97283481
118Carpal bone hypoplasia (HP:0001498)1.97010902
119Abnormality of the preputium (HP:0100587)1.96881102
120Chronic hepatic failure (HP:0100626)1.95612712
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.94869669
122Leukodystrophy (HP:0002415)1.94599360
123Supernumerary spleens (HP:0009799)1.93982349
124Microretrognathia (HP:0000308)1.93574522
125Renal cortical cysts (HP:0000803)1.92857304
126Type II lissencephaly (HP:0007260)1.92623231
127Muscle fiber atrophy (HP:0100295)1.92221869
128Abnormal lung lobation (HP:0002101)1.90737428
129Chromsome breakage (HP:0040012)1.90710638
130Gliosis (HP:0002171)1.90197227
131Esophageal neoplasm (HP:0100751)1.88618111
132Neoplasm of head and neck (HP:0012288)1.88618111
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88560740
134Pancytopenia (HP:0001876)1.88543925
135Optic nerve hypoplasia (HP:0000609)1.88355363
136Abnormality of the duodenum (HP:0002246)1.86996548
137Cystic liver disease (HP:0006706)1.85743472
138Hyperglycinuria (HP:0003108)1.85424672
139Patellar aplasia (HP:0006443)1.85290490
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85151247
141Septo-optic dysplasia (HP:0100842)1.84368088
142Muscle fiber splitting (HP:0003555)1.84152340
143Large for gestational age (HP:0001520)1.83308613
144Duodenal stenosis (HP:0100867)1.83169309
145Small intestinal stenosis (HP:0012848)1.83169309
146Gaze-evoked nystagmus (HP:0000640)1.82207787
147Abnormality of methionine metabolism (HP:0010901)1.81902733
148Male pseudohermaphroditism (HP:0000037)1.80953695
149Dandy-Walker malformation (HP:0001305)1.80900691
150Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80583790
151Anencephaly (HP:0002323)1.80258159
152Pallor (HP:0000980)1.80163468
153Progressive inability to walk (HP:0002505)1.79727250
154Muscle fiber inclusion bodies (HP:0100299)1.79577984
155Poor coordination (HP:0002370)1.79166291
156Testicular atrophy (HP:0000029)1.78964416
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78928421
158Furrowed tongue (HP:0000221)1.78927500
159Broad-based gait (HP:0002136)1.78100017
160Abnormality of vitamin B metabolism (HP:0004340)1.77073794
161Abnormal biliary tract physiology (HP:0012439)1.76378046
162Bile duct proliferation (HP:0001408)1.76378046
163Attenuation of retinal blood vessels (HP:0007843)1.75289414
164Glioma (HP:0009733)1.75063365
165Preaxial hand polydactyly (HP:0001177)1.73991917
166Aplasia/Hypoplasia of the patella (HP:0006498)1.72927668
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.72638943
168Triphalangeal thumb (HP:0001199)1.72544696
169Postaxial hand polydactyly (HP:0001162)1.72180550
170Lissencephaly (HP:0001339)1.72091601
171Gastrointestinal atresia (HP:0002589)1.71953320
172Ependymoma (HP:0002888)1.71726281
173Pancreatic islet-cell hyperplasia (HP:0004510)1.71305980
174Inability to walk (HP:0002540)1.71026175
175Abnormality of serine family amino acid metabolism (HP:0010894)1.70196317
176Abnormality of glycine metabolism (HP:0010895)1.70196317
177Postaxial foot polydactyly (HP:0001830)1.70118695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.83551850
2FRK3.60903208
3BUB13.52884762
4NEK13.31120127
5WEE13.19595935
6NME22.91558236
7WNK32.86405473
8STK162.76196555
9BMPR1B2.72915808
10OBSCN2.72147340
11BCKDK2.70570157
12TRIM282.59522735
13ZAK2.38889414
14MYLK2.35152673
15PDK42.26430345
16PDK32.26430345
17PLK42.17327260
18MAP4K22.15877527
19SRPK12.13405422
20MAP3K42.08173608
21CDC72.06344363
22EIF2AK32.02419798
23TNIK1.97547405
24CASK1.96311885
25VRK11.95864801
26NME11.92138437
27NUAK11.80076022
28ACVR1B1.72462886
29BRSK21.72211210
30TSSK61.70897954
31ADRBK21.58605873
32STK38L1.56451431
33STK241.55557032
34TTN1.54930866
35GRK11.54318824
36VRK21.49250142
37PDK21.48417165
38INSRR1.46979513
39TTK1.44232458
40BCR1.41017693
41PNCK1.40693062
42PLK11.40536885
43PINK11.38199299
44MAP2K71.36238730
45IRAK31.34475406
46TLK11.34430902
47CCNB11.34119803
48STK391.33680529
49ERBB31.31478016
50LMTK21.29853999
51TAF11.29613845
52OXSR11.27853803
53AURKB1.27524428
54PIM21.21421002
55KDR1.20097343
56NEK21.19663890
57CSNK1G11.14414984
58WNK41.11873515
59MKNK11.11829113
60FLT31.11726758
61MAPK131.09534614
62EIF2AK21.07640253
63STK41.05275689
64DYRK21.04421318
65PLK21.02485515
66MUSK1.02167638
67MAP2K31.01540378
68PLK31.01429763
69CSNK1G21.01038565
70ATR1.00745321
71BRSK11.00627239
72NEK90.97877981
73CSNK1G30.97470674
74MAP3K110.96644090
75PBK0.95556276
76ILK0.94935108
77RPS6KA40.94047506
78RPS6KB20.93665877
79CDK70.93075426
80AURKA0.88549886
81PKN20.87529648
82FGFR20.87302261
83PHKG20.85611743
84PHKG10.85611743
85CDK80.84804801
86MKNK20.84044500
87PIK3CA0.82492335
88PAK30.82226994
89IRAK40.82138641
90CSNK1A1L0.81766040
91TESK20.81678977
92MAP2K60.80170887
93EPHA40.77716686
94TESK10.75822611
95PRKCG0.75689721
96MAPKAPK30.72808519
97TEC0.71818248
98STK30.68990096
99CSNK2A10.68825830
100CDK40.68565765
101MARK10.66711409
102PRKCE0.65372195
103DYRK30.64724685
104CHEK20.64447483
105ABL20.61773311
106BRAF0.57707235
107TGFBR10.57604036
108NLK0.55698900
109PIM10.55217627
110SCYL20.54991900
111MAP3K30.54703465
112PAK40.54531369
113TAOK20.54206635
114GRK70.54043348
115CSNK2A20.53012725
116TIE10.51584333
117PASK0.50238202
118RPS6KA50.49499040
119MAP3K80.47965101
120CDK30.46936166
121RPS6KL10.45921165
122RPS6KC10.45921165
123MAP3K120.45855977
124FGFR10.45575339
125CSNK1E0.45098403
126MAP3K50.44523595
127ADRBK10.43309441
128CHEK10.42019967
129RPS6KA60.41490544
130PIK3CG0.40151546
131CAMKK20.39803728
132LRRK20.39775925
133MST40.39084440
134DAPK20.38956869
135ATM0.36072275
136PRKCI0.35214205
137EPHA20.34869488
138MINK10.34195226
139CSNK1A10.33535826
140LIMK10.31410524
141CAMK2A0.31278856
142MAPKAPK50.30892994
143AKT30.30756096
144CSNK1D0.30314871
145AKT20.30031172
146CDK10.29780763
147PAK10.29288555
148CDK20.28584852
149CDK190.27633945
150PRKDC0.27491073
151DAPK30.27108051
152FER0.26843536

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.87840337
2Proteasome_Homo sapiens_hsa030503.82082445
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.68657218
4Ribosome_Homo sapiens_hsa030103.55250028
5Mismatch repair_Homo sapiens_hsa034303.30110934
6Parkinsons disease_Homo sapiens_hsa050123.10210128
7Oxidative phosphorylation_Homo sapiens_hsa001903.09223615
8RNA polymerase_Homo sapiens_hsa030202.90737218
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58403185
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.48928827
11Pyrimidine metabolism_Homo sapiens_hsa002402.35872391
12Homologous recombination_Homo sapiens_hsa034402.33250500
13Huntingtons disease_Homo sapiens_hsa050162.30715542
14Base excision repair_Homo sapiens_hsa034102.26482168
15Spliceosome_Homo sapiens_hsa030402.15068302
16Nucleotide excision repair_Homo sapiens_hsa034202.14612746
17RNA transport_Homo sapiens_hsa030131.96928749
18One carbon pool by folate_Homo sapiens_hsa006701.90786114
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89260222
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88494083
21Alzheimers disease_Homo sapiens_hsa050101.86630427
22Carbon metabolism_Homo sapiens_hsa012001.86548391
23Cardiac muscle contraction_Homo sapiens_hsa042601.78199464
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68551806
25Propanoate metabolism_Homo sapiens_hsa006401.59365101
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.57045583
27Phototransduction_Homo sapiens_hsa047441.47466992
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47097869
29RNA degradation_Homo sapiens_hsa030181.43721819
30Fanconi anemia pathway_Homo sapiens_hsa034601.42603378
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40618264
32Biosynthesis of amino acids_Homo sapiens_hsa012301.39596440
33Cell cycle_Homo sapiens_hsa041101.38933694
34Purine metabolism_Homo sapiens_hsa002301.36305959
35Steroid biosynthesis_Homo sapiens_hsa001001.30612610
36Non-homologous end-joining_Homo sapiens_hsa034501.27705164
37Protein export_Homo sapiens_hsa030601.26006808
38Pyruvate metabolism_Homo sapiens_hsa006201.25839565
39Nicotine addiction_Homo sapiens_hsa050331.25512611
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.25098751
41Basal transcription factors_Homo sapiens_hsa030221.20113766
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19361411
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18109390
44Fatty acid degradation_Homo sapiens_hsa000711.09901049
45Folate biosynthesis_Homo sapiens_hsa007901.08997557
46Nitrogen metabolism_Homo sapiens_hsa009101.08137828
47Pentose phosphate pathway_Homo sapiens_hsa000301.07704594
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05442593
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04373623
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99578202
51Fructose and mannose metabolism_Homo sapiens_hsa000510.94194650
52Linoleic acid metabolism_Homo sapiens_hsa005910.91691020
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90023753
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88470438
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86642036
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86430454
57Galactose metabolism_Homo sapiens_hsa000520.85942800
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85517039
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.83757057
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83645085
61Ether lipid metabolism_Homo sapiens_hsa005650.80187384
62Glutathione metabolism_Homo sapiens_hsa004800.79826578
63Taste transduction_Homo sapiens_hsa047420.79288360
64p53 signaling pathway_Homo sapiens_hsa041150.78855825
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75043754
66Sulfur relay system_Homo sapiens_hsa041220.74533178
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.72627824
68Metabolic pathways_Homo sapiens_hsa011000.72399683
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72208183
70Selenocompound metabolism_Homo sapiens_hsa004500.70959330
71Sulfur metabolism_Homo sapiens_hsa009200.70936910
72Epstein-Barr virus infection_Homo sapiens_hsa051690.69601196
73Retinol metabolism_Homo sapiens_hsa008300.67552577
74Legionellosis_Homo sapiens_hsa051340.62332875
75mRNA surveillance pathway_Homo sapiens_hsa030150.62083342
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62076909
77Fatty acid metabolism_Homo sapiens_hsa012120.61622805
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60438591
79Vitamin digestion and absorption_Homo sapiens_hsa049770.59643067
80Olfactory transduction_Homo sapiens_hsa047400.58040343
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.56847248
82Hedgehog signaling pathway_Homo sapiens_hsa043400.55949069
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54888801
84Chemical carcinogenesis_Homo sapiens_hsa052040.54642813
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54642486
86Peroxisome_Homo sapiens_hsa041460.54391508
87beta-Alanine metabolism_Homo sapiens_hsa004100.52796272
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50902229
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.50209976
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49896040
91Arginine and proline metabolism_Homo sapiens_hsa003300.49738740
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47893420
93GABAergic synapse_Homo sapiens_hsa047270.47357376
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46437473
95TGF-beta signaling pathway_Homo sapiens_hsa043500.45515591
96Fat digestion and absorption_Homo sapiens_hsa049750.45490509
97Systemic lupus erythematosus_Homo sapiens_hsa053220.44766316
98Phenylalanine metabolism_Homo sapiens_hsa003600.44493455
99Circadian rhythm_Homo sapiens_hsa047100.43376827
100Herpes simplex infection_Homo sapiens_hsa051680.43358635
101Serotonergic synapse_Homo sapiens_hsa047260.42071987
102Basal cell carcinoma_Homo sapiens_hsa052170.42046713
103Collecting duct acid secretion_Homo sapiens_hsa049660.39495846
104Dilated cardiomyopathy_Homo sapiens_hsa054140.39053686
105Alcoholism_Homo sapiens_hsa050340.38646009
106Fatty acid elongation_Homo sapiens_hsa000620.38623080
107Starch and sucrose metabolism_Homo sapiens_hsa005000.37335051
108Arachidonic acid metabolism_Homo sapiens_hsa005900.37239497
109Morphine addiction_Homo sapiens_hsa050320.34964263
110Insulin secretion_Homo sapiens_hsa049110.34828128
111Hippo signaling pathway_Homo sapiens_hsa043900.33256713
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32759958
113Antigen processing and presentation_Homo sapiens_hsa046120.29610172
114HIF-1 signaling pathway_Homo sapiens_hsa040660.28876497
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26753731
116Viral myocarditis_Homo sapiens_hsa054160.25566330
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24141044
118Tryptophan metabolism_Homo sapiens_hsa003800.21546337
119N-Glycan biosynthesis_Homo sapiens_hsa005100.21256151
120Tyrosine metabolism_Homo sapiens_hsa003500.20071063
121Regulation of autophagy_Homo sapiens_hsa041400.16183551
122Oocyte meiosis_Homo sapiens_hsa041140.15845152
123Caffeine metabolism_Homo sapiens_hsa002320.12983691
124Viral carcinogenesis_Homo sapiens_hsa052030.12357963
125HTLV-I infection_Homo sapiens_hsa051660.12164715
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11804027
127Butanoate metabolism_Homo sapiens_hsa006500.11081644
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10772629
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10349982
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07872121
131Thyroid cancer_Homo sapiens_hsa052160.06069307
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05560898
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05486812
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04924704
135Vitamin B6 metabolism_Homo sapiens_hsa007500.04071469
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02895955
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.02081189
138Other glycan degradation_Homo sapiens_hsa005110.02077119
139Apoptosis_Homo sapiens_hsa042100.01016207

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