ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.62329706
2	viral transcription (GO:0019083)	6.60284546
3	ribosomal small subunit biogenesis (GO:0042274)	6.59513415
4	translational termination (GO:0006415)	6.41734198
5	ribosomal small subunit assembly (GO:0000028)	6.40865763
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.40365398
7	ATP synthesis coupled proton transport (GO:0015986)	6.40365398
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.77011126
9	cotranslational protein targeting to membrane (GO:0006613)	5.76848292
10	protein targeting to ER (GO:0045047)	5.69042364
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.53661618
12	maturation of SSU-rRNA (GO:0030490)	5.52839422
13	translational elongation (GO:0006414)	5.52471837
14	protein localization to endoplasmic reticulum (GO:0070972)	5.42740034
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.41660462
16	ribosomal large subunit biogenesis (GO:0042273)	5.23542143
17	proteasome assembly (GO:0043248)	5.23484540
18	respiratory electron transport chain (GO:0022904)	5.21614192
19	viral life cycle (GO:0019058)	5.10644995
20	electron transport chain (GO:0022900)	5.09868948
21	cellular protein complex disassembly (GO:0043624)	5.04716186
22	translational initiation (GO:0006413)	4.97036121
23	DNA deamination (GO:0045006)	4.81434355
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.69555056
25	termination of RNA polymerase III transcription (GO:0006386)	4.69331552
26	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.69331552
27	* translation (GO:0006412)	4.60996791
28	chaperone-mediated protein transport (GO:0072321)	4.60550419
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.29264458
30	NADH dehydrogenase complex assembly (GO:0010257)	4.29264458
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.29264458
32	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.28244604
33	protein complex disassembly (GO:0043241)	4.28082421
34	GTP biosynthetic process (GO:0006183)	4.25285841
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.21747760
36	protein neddylation (GO:0045116)	4.21317495
37	protein complex biogenesis (GO:0070271)	4.12261413
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.08930513
39	macromolecular complex disassembly (GO:0032984)	4.08366119
40	ribonucleoprotein complex biogenesis (GO:0022613)	4.07214957
41	protein targeting to mitochondrion (GO:0006626)	3.95103707
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.90797150
43	establishment of protein localization to mitochondrion (GO:0072655)	3.90171373
44	cellular component biogenesis (GO:0044085)	3.85753095
45	protein targeting to membrane (GO:0006612)	3.81799014
46	negative regulation of ligase activity (GO:0051352)	3.80527053
47	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.80527053
48	regulation of cellular amino acid metabolic process (GO:0006521)	3.79674085
49	UTP biosynthetic process (GO:0006228)	3.79437271
50	7-methylguanosine mRNA capping (GO:0006370)	3.79239146
51	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.77571263
52	guanosine-containing compound biosynthetic process (GO:1901070)	3.77196272
53	RNA capping (GO:0036260)	3.73530113
54	7-methylguanosine RNA capping (GO:0009452)	3.73530113
55	regulation of mitochondrial translation (GO:0070129)	3.71373586
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.67003342
57	protein maturation by protein folding (GO:0022417)	3.63839987
58	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.61345415
59	rRNA processing (GO:0006364)	3.60739903
60	amino acid salvage (GO:0043102)	3.59350978
61	L-methionine salvage (GO:0071267)	3.59350978
62	L-methionine biosynthetic process (GO:0071265)	3.59350978
63	protein localization to mitochondrion (GO:0070585)	3.56265007
64	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.55039928
65	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.53940380
66	respiratory chain complex IV assembly (GO:0008535)	3.53752341
67	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.52107651
68	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.52107651
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51508247
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51508247
71	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.50711256
72	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.49765550
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.49765550
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.49765550
75	oxidative phosphorylation (GO:0006119)	3.48141053
76	rRNA metabolic process (GO:0016072)	3.44808218
77	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.44188572
78	base-excision repair, AP site formation (GO:0006285)	3.43732202
79	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.42675158
80	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.42030060
81	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.42030060
82	cytochrome complex assembly (GO:0017004)	3.41584798
83	UTP metabolic process (GO:0046051)	3.41386906
84	cullin deneddylation (GO:0010388)	3.41189298
85	spliceosomal snRNP assembly (GO:0000387)	3.39821957
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.37462471
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.36537653
88	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.36048749
89	inner mitochondrial membrane organization (GO:0007007)	3.35735393
90	rRNA modification (GO:0000154)	3.35449001
91	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.34261110
92	iron-sulfur cluster assembly (GO:0016226)	3.32890314
93	metallo-sulfur cluster assembly (GO:0031163)	3.32890314
94	formation of translation preinitiation complex (GO:0001731)	3.32728621
95	pseudouridine synthesis (GO:0001522)	3.32430484
96	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.31264007
97	CTP metabolic process (GO:0046036)	3.29829879
98	CTP biosynthetic process (GO:0006241)	3.29829879
99	establishment of integrated proviral latency (GO:0075713)	3.24877483
100	peptidyl-histidine modification (GO:0018202)	3.24417931
101	protein deneddylation (GO:0000338)	3.23749528
102	ATP biosynthetic process (GO:0006754)	3.19072106
103	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.17100127
104	mRNA catabolic process (GO:0006402)	3.16992958
105	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.16966112
106	mitochondrial transport (GO:0006839)	3.14538624
107	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.14121872
108	nucleoside triphosphate biosynthetic process (GO:0009142)	3.12998699
109	positive regulation of ligase activity (GO:0051351)	3.09660657
110	DNA damage response, detection of DNA damage (GO:0042769)	3.09075300
111	hydrogen ion transmembrane transport (GO:1902600)	3.02537117
112	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.01192080
113	intracellular protein transmembrane import (GO:0044743)	2.98814016
114	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96588282
115	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.93042597

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.88600392
2	* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.65389433
3	* GABP_17652178_ChIP-ChIP_JURKAT_Human	4.41261874
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.26708041
5	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.18927497
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.05075096
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.93892819
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.84135074
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.70597180
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.59772361
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.55160545
12	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.21435537
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.19524499
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.13125100
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.12799380
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01826585
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.84263572
18	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.71841461
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.68929150
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.68780032
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.64289116
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.61602411
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.42344566
24	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.42024932
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.38617643
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.28547348
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.16791654
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16761728
29	* GABP_19822575_ChIP-Seq_HepG2_Human	2.03491320
30	TTF2_22483619_ChIP-Seq_HELA_Human	2.02614314
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.02330380
32	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.00010677
33	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.87871008
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84661132
35	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.84606638
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.83423730
37	E2F7_22180533_ChIP-Seq_HELA_Human	1.83195826
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83050195
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.69919666
40	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69160847
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.67573307
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66867552
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.61745614
44	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.57810021
45	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.50895946
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.49946314
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.47873855
48	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.39773410
49	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.38871322
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37277551
51	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.34003391
52	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.33714717
53	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.32391025
54	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28302815
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26742628
56	* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22168228
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21995367
58	* TET1_21451524_ChIP-Seq_MESCs_Mouse	1.21245805
59	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20291283
60	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.19609740
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.19025510
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17787569
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17719824
64	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.16502513
65	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.16494444
66	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.16482516
67	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.15401326
68	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.11493813
69	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.10902557
70	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08521456
71	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.07805333
72	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.06671070
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06313378
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05859359
75	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.04878787
76	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04757611
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00663336
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99351265
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.98336706
80	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.96893828
81	* YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95498478
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93651612
83	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93015383
84	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.92529183
85	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.90458368
86	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89637701
87	ZNF263_19887448_ChIP-Seq_K562_Human	0.88448820
88	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.88236291
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.87937577
90	TFEB_21752829_ChIP-Seq_HELA_Human	0.87478517
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86808237
92	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.86612543
93	SPI1_23547873_ChIP-Seq_NB4_Human	0.86343176
94	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.85095708
95	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.84787630
96	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.84484617
97	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.84294894
98	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.83744556
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.82845187
100	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.81580232
101	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.81166935
102	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.81053590
103	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.80905574
104	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.80344145
105	CTCF_20526341_ChIP-Seq_ESCs_Human	0.78759520
106	* TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.78370308
107	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.78153768
108	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.77627453
109	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.77431285
110	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.76272398
111	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.73231850
112	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.71872816
113	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.71771936
114	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.71282918
115	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.71155646
116	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.70613296

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.49252618
2	MP0003693_abnormal_embryo_hatching	3.91574506
3	MP0003806_abnormal_nucleotide_metabolis	3.52313652
4	MP0010030_abnormal_orbit_morphology	3.32778207
5	MP0001529_abnormal_vocalization	3.21266278
6	MP0003186_abnormal_redox_activity	3.20349909
7	MP0003136_yellow_coat_color	3.05360901
8	MP0004957_abnormal_blastocyst_morpholog	2.94922548
9	MP0005451_abnormal_body_composition	2.93444866
10	MP0006036_abnormal_mitochondrial_physio	2.91096274
11	MP0008260_abnormal_autophagy	2.41514767
12	MP0008932_abnormal_embryonic_tissue	2.37205538
13	MP0001905_abnormal_dopamine_level	2.27350382
14	MP0006035_abnormal_mitochondrial_morpho	2.15501506
15	MP0002132_abnormal_respiratory_system	2.12595532
16	MP0003718_maternal_effect	2.03586643
17	MP0003950_abnormal_plasma_membrane	1.91976922
18	MP0004142_abnormal_muscle_tone	1.84418314
19	MP0004381_abnormal_hair_follicle	1.82178076
20	MP0005409_darkened_coat_color	1.81274368
21	MP0008058_abnormal_DNA_repair	1.78887676
22	MP0003077_abnormal_cell_cycle	1.77336825
23	MP0001986_abnormal_taste_sensitivity	1.75765818
24	MP0005394_taste/olfaction_phenotype	1.71771342
25	MP0005499_abnormal_olfactory_system	1.71771342
26	MP0000920_abnormal_myelination	1.65780272
27	MP0000049_abnormal_middle_ear	1.64302955
28	MP0003786_premature_aging	1.62502045
29	MP0010094_abnormal_chromosome_stability	1.61604271
30	MP0005075_abnormal_melanosome_morpholog	1.61473991
31	MP0009333_abnormal_splenocyte_physiolog	1.59426761
32	MP0000372_irregular_coat_pigmentation	1.53894729
33	MP0003111_abnormal_nucleus_morphology	1.48945904
34	MP0009840_abnormal_foam_cell	1.41704213
35	MP0003646_muscle_fatigue	1.41663811
36	MP0001727_abnormal_embryo_implantation	1.40719287
37	MP0008057_abnormal_DNA_replication	1.39418127
38	MP0003011_delayed_dark_adaptation	1.34741175
39	MP0006292_abnormal_olfactory_placode	1.33055154
40	MP0002148_abnormal_hypersensitivity_rea	1.31220758
41	MP0003315_abnormal_perineum_morphology	1.30955893
42	MP0001542_abnormal_bone_strength	1.28748587
43	MP0000490_abnormal_crypts_of	1.27939855
44	MP0005379_endocrine/exocrine_gland_phen	1.27345146
45	MP0000749_muscle_degeneration	1.26729744
46	MP0001293_anophthalmia	1.26465677
47	MP0001346_abnormal_lacrimal_gland	1.23714922
48	MP0002638_abnormal_pupillary_reflex	1.23554312
49	MP0006072_abnormal_retinal_apoptosis	1.22890692
50	MP0002160_abnormal_reproductive_system	1.22022859
51	MP0003221_abnormal_cardiomyocyte_apopto	1.22008266
52	MP0003656_abnormal_erythrocyte_physiolo	1.21670768
53	MP0000358_abnormal_cell_content/	1.15319141
54	MP0001984_abnormal_olfaction	1.12290313
55	MP0001764_abnormal_homeostasis	1.06718386
56	MP0002938_white_spotting	1.06705682
57	MP0005408_hypopigmentation	1.06536962
58	MP0005423_abnormal_somatic_nervous	1.05013904
59	MP0005174_abnormal_tail_pigmentation	1.04155780
60	MP0001188_hyperpigmentation	1.04021421
61	MP0002210_abnormal_sex_determination	1.03573761
62	MP0006276_abnormal_autonomic_nervous	1.02038419
63	MP0001485_abnormal_pinna_reflex	0.97348117
64	MP0002277_abnormal_respiratory_mucosa	0.94270568
65	MP0003942_abnormal_urinary_system	0.91681452
66	MP0005330_cardiomyopathy	0.88581495
67	MP0002653_abnormal_ependyma_morphology	0.87883470
68	MP0009785_altered_susceptibility_to	0.87212734
69	MP0000015_abnormal_ear_pigmentation	0.87152831
70	MP0004145_abnormal_muscle_electrophysio	0.86488544
71	MP0005266_abnormal_metabolism	0.86167966
72	MP0000026_abnormal_inner_ear	0.85834410
73	MP0002751_abnormal_autonomic_nervous	0.85502393
74	MP0002102_abnormal_ear_morphology	0.84981462
75	MP0002090_abnormal_vision	0.84629237
76	MP0002249_abnormal_larynx_morphology	0.83706080
77	MP0005636_abnormal_mineral_homeostasis	0.83579536
78	MP0005332_abnormal_amino_acid	0.82652257
79	MP0000313_abnormal_cell_death	0.82541480
80	MP0003121_genomic_imprinting	0.82316200
81	MP0002163_abnormal_gland_morphology	0.81342484
82	MP0003123_paternal_imprinting	0.80855613
83	MP0003941_abnormal_skin_development	0.80706974
84	MP0001730_embryonic_growth_arrest	0.80270755
85	MP0000631_abnormal_neuroendocrine_gland	0.80029775
86	MP0002736_abnormal_nociception_after	0.79669543
87	MP0000566_synostosis	0.79548552
88	MP0009053_abnormal_anal_canal	0.79490444
89	MP0005389_reproductive_system_phenotype	0.78726005
90	MP0008875_abnormal_xenobiotic_pharmacok	0.78480672
91	MP0002233_abnormal_nose_morphology	0.78202808
92	MP0008007_abnormal_cellular_replicative	0.78145970
93	MP0005501_abnormal_skin_physiology	0.77618132
94	MP0000762_abnormal_tongue_morphology	0.77210969
95	MP0000747_muscle_weakness	0.76425047
96	MP0001929_abnormal_gametogenesis	0.76269368
97	MP0003937_abnormal_limbs/digits/tail_de	0.75982690
98	MP0005670_abnormal_white_adipose	0.75929505
99	MP0005025_abnormal_response_to	0.75594119
100	MP0001145_abnormal_male_reproductive	0.74304076
101	MP0002752_abnormal_somatic_nervous	0.73177447
102	MP0002095_abnormal_skin_pigmentation	0.72450591
103	MP0003137_abnormal_impulse_conducting	0.72112430
104	MP0004742_abnormal_vestibular_system	0.72020611
105	MP0004019_abnormal_vitamin_homeostasis	0.71700620
106	MP0008789_abnormal_olfactory_epithelium	0.71543586
107	MP0000653_abnormal_sex_gland	0.71441804
108	MP0002723_abnormal_immune_serum	0.70354082
109	MP0005000_abnormal_immune_tolerance	0.70333003
110	MP0001661_extended_life_span	0.70276286
111	MP0003724_increased_susceptibility_to	0.70268876
112	MP0009250_abnormal_appendicular_skeleto	0.69816527
113	MP0000647_abnormal_sebaceous_gland	0.69060951
114	MP0001853_heart_inflammation	0.69058138
115	MP0002822_catalepsy	0.68936106
116	MP0001919_abnormal_reproductive_system	0.68305216
117	MP0008995_early_reproductive_senescence	0.68046180
118	MP0002837_dystrophic_cardiac_calcinosis	0.68021601
119	MP0003880_abnormal_central_pattern	0.67388869
120	MP0001968_abnormal_touch/_nociception	0.67178995
121	MP0000678_abnormal_parathyroid_gland	0.67149630
122	MP0005376_homeostasis/metabolism_phenot	0.66138698
123	MP0005551_abnormal_eye_electrophysiolog	0.65269313
124	MP0003119_abnormal_digestive_system	0.64893958
125	MP0005084_abnormal_gallbladder_morpholo	0.64633279
126	MP0003938_abnormal_ear_development	0.64139647
127	MP0002282_abnormal_trachea_morphology	0.63713255
128	MP0002111_abnormal_tail_morphology	0.63579840
129	MP0002876_abnormal_thyroid_physiology	0.63302289
130	MP0004133_heterotaxia	0.62725285
131	MP0002396_abnormal_hematopoietic_system	0.62234742
132	MP0002429_abnormal_blood_cell	0.62131434
133	MP0002019_abnormal_tumor_incidence	0.61480151
134	MP0000750_abnormal_muscle_regeneration	0.61351759
135	MP0005410_abnormal_fertilization	0.61346366
136	MP0003567_abnormal_fetal_cardiomyocyte	0.60722413
137	MP0005381_digestive/alimentary_phenotyp	0.60598341
138	MP0001663_abnormal_digestive_system	0.59780289
139	MP0008873_increased_physiological_sensi	0.58891520
140	MP0000689_abnormal_spleen_morphology	0.58251933
141	MP0005671_abnormal_response_to	0.57686004
142	MP0008469_abnormal_protein_level	0.57309936
143	MP0004147_increased_porphyrin_level	0.57257484
144	MP0005083_abnormal_biliary_tract	0.56918001
145	MP0002229_neurodegeneration	0.56204090
146	MP0002722_abnormal_immune_system	0.55854097
147	MP0004036_abnormal_muscle_relaxation	0.54822189
148	MP0002420_abnormal_adaptive_immunity	0.54667129

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.02634162
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.55397514
3	Mitochondrial inheritance (HP:0001427)	5.51561401
4	Abnormality of cells of the erythroid lineage (HP:0012130)	5.39989882
5	Acute encephalopathy (HP:0006846)	5.11317400
6	Hepatocellular necrosis (HP:0001404)	5.11107668
7	Abnormal number of erythroid precursors (HP:0012131)	4.92447102
8	Increased CSF lactate (HP:0002490)	4.79877186
9	Progressive macrocephaly (HP:0004481)	4.79465798
10	Increased hepatocellular lipid droplets (HP:0006565)	4.66131034
11	Hepatic necrosis (HP:0002605)	4.59437462
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.54452509
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.54452509
14	Reticulocytopenia (HP:0001896)	4.41337838
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.35596526
16	Lipid accumulation in hepatocytes (HP:0006561)	4.25254454
17	Cerebral hypomyelination (HP:0006808)	4.15833757
18	Abnormality of glycolysis (HP:0004366)	4.13007848
19	Increased serum pyruvate (HP:0003542)	4.13007848
20	Renal Fanconi syndrome (HP:0001994)	4.09456927
21	3-Methylglutaconic aciduria (HP:0003535)	4.03841810
22	Macrocytic anemia (HP:0001972)	3.96246526
23	Increased intramyocellular lipid droplets (HP:0012240)	3.94249113
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.93288727
25	Increased serum lactate (HP:0002151)	3.80151841
26	Cerebral edema (HP:0002181)	3.63733427
27	Respiratory failure (HP:0002878)	3.53552597
28	Exertional dyspnea (HP:0002875)	3.49043870
29	Lactic acidosis (HP:0003128)	3.48747405
30	Exercise intolerance (HP:0003546)	3.46601988
31	Leukodystrophy (HP:0002415)	3.44329955
32	Increased muscle lipid content (HP:0009058)	3.42442082
33	Pallor (HP:0000980)	3.19660883
34	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.10408422
35	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.08655608
36	Optic disc pallor (HP:0000543)	2.94807127
37	Respiratory difficulties (HP:0002880)	2.74245294
38	CNS demyelination (HP:0007305)	2.72649587
39	Degeneration of anterior horn cells (HP:0002398)	2.71942351
40	Abnormality of the anterior horn cell (HP:0006802)	2.71942351
41	Hyperglycinemia (HP:0002154)	2.66528257
42	Abnormality of renal resorption (HP:0011038)	2.61165776
43	Parakeratosis (HP:0001036)	2.49586611
44	Lethargy (HP:0001254)	2.42807291
45	Emotional lability (HP:0000712)	2.41471548
46	Type I transferrin isoform profile (HP:0003642)	2.37258638
47	Congenital ichthyosiform erythroderma (HP:0007431)	2.36618088
48	Adrenal hypoplasia (HP:0000835)	2.35206402
49	CNS hypomyelination (HP:0003429)	2.32991616
50	Spastic paraparesis (HP:0002313)	2.29853726
51	Oral leukoplakia (HP:0002745)	2.24247294
52	Aplastic anemia (HP:0001915)	2.21539485
53	Rough bone trabeculation (HP:0100670)	2.19605785
54	Amniotic constriction ring (HP:0009775)	2.19517830
55	Abnormality of placental membranes (HP:0011409)	2.19517830
56	Testicular atrophy (HP:0000029)	2.19222536
57	Breast hypoplasia (HP:0003187)	2.16583715
58	Glycosuria (HP:0003076)	2.15442406
59	Abnormality of urine glucose concentration (HP:0011016)	2.15442406
60	Hyperphosphaturia (HP:0003109)	2.15246878
61	Myokymia (HP:0002411)	2.13990980
62	Microvesicular hepatic steatosis (HP:0001414)	2.10168771
63	Multiple enchondromatosis (HP:0005701)	2.08353963
64	Double outlet right ventricle (HP:0001719)	2.07176157
65	Congenital malformation of the right heart (HP:0011723)	2.07176157
66	Opisthotonus (HP:0002179)	2.04685139
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04504566
68	Abnormality of alanine metabolism (HP:0010916)	2.04504566
69	Hyperalaninemia (HP:0003348)	2.04504566
70	Generalized aminoaciduria (HP:0002909)	2.01659388
71	Abnormal pupillary function (HP:0007686)	2.00757797
72	Ragged-red muscle fibers (HP:0003200)	1.97470045
73	Sclerocornea (HP:0000647)	1.92376871
74	Secondary amenorrhea (HP:0000869)	1.92233780
75	Delusions (HP:0000746)	1.91504040
76	Abnormal hemoglobin (HP:0011902)	1.91343208
77	Postnatal microcephaly (HP:0005484)	1.90527604
78	Molar tooth sign on MRI (HP:0002419)	1.87582718
79	Abnormality of midbrain morphology (HP:0002418)	1.87582718
80	Hypokinesia (HP:0002375)	1.86859707
81	Hypoplasia of the uterus (HP:0000013)	1.83053169
82	Abnormality of glycine metabolism (HP:0010895)	1.82006688
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82006688
84	Hypoplastic left heart (HP:0004383)	1.81377743
85	Pancytopenia (HP:0001876)	1.80616599
86	Facial cleft (HP:0002006)	1.80417094
87	Hyperglycinuria (HP:0003108)	1.79574222
88	Abnormal glycosylation (HP:0012345)	1.78619322
89	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78619322
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.78619322
91	Abnormal protein glycosylation (HP:0012346)	1.78619322
92	Muscle fiber atrophy (HP:0100295)	1.78269228
93	Abnormal urine phosphate concentration (HP:0012599)	1.77655283
94	Progressive muscle weakness (HP:0003323)	1.77070095
95	Methylmalonic aciduria (HP:0012120)	1.76978197
96	Birth length less than 3rd percentile (HP:0003561)	1.76653038
97	Abnormality of serum amino acid levels (HP:0003112)	1.76501593
98	Pancreatic fibrosis (HP:0100732)	1.76318522
99	Abnormality of the labia minora (HP:0012880)	1.76287140
100	Hepatosplenomegaly (HP:0001433)	1.76251865
101	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76070042
102	Dicarboxylic aciduria (HP:0003215)	1.76070042
103	Neuroendocrine neoplasm (HP:0100634)	1.74985704
104	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74797565
105	Reduced antithrombin III activity (HP:0001976)	1.74534702
106	Asplenia (HP:0001746)	1.70665758
107	Prolonged neonatal jaundice (HP:0006579)	1.70562092
108	Abnormality of the umbilical cord (HP:0010881)	1.69557483
109	Abnormal umbilical cord blood vessels (HP:0011403)	1.69494933
110	Single umbilical artery (HP:0001195)	1.69494933
111	Abnormality of the fetal cardiovascular system (HP:0010948)	1.69494933
112	Blindness (HP:0000618)	1.68667412
113	X-linked dominant inheritance (HP:0001423)	1.68271961
114	Microretrognathia (HP:0000308)	1.67317951
115	True hermaphroditism (HP:0010459)	1.66152237
116	Abnormal trabecular bone morphology (HP:0100671)	1.65460761
117	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.64882866
118	Gliosis (HP:0002171)	1.64852598
119	Carpal bone hypoplasia (HP:0001498)	1.62848345
120	Trismus (HP:0000211)	1.62828676
121	Occipital encephalocele (HP:0002085)	1.62065564
122	Premature ovarian failure (HP:0008209)	1.61650221
123	Sensory axonal neuropathy (HP:0003390)	1.61368591
124	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.60167902
125	Poor suck (HP:0002033)	1.60133009
126	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.59655460
127	Stenosis of the external auditory canal (HP:0000402)	1.54746940
128	Abnormalities of placenta or umbilical cord (HP:0001194)	1.54718915
129	Type 2 muscle fiber atrophy (HP:0003554)	1.53870919
130	Unsteady gait (HP:0002317)	1.53693505

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.10088852
2	NME2	4.74630509
3	BUB1	4.19930177
4	STK16	4.03463380
5	TLK1	3.55497688
6	EIF2AK1	3.43312896
7	NME1	3.16997222
8	PBK	2.86281115
9	WEE1	2.74727608
10	MST4	2.45523692
11	PDK2	2.31103213
12	TESK2	2.23395759
13	EIF2AK3	2.04541867
14	PIM2	2.01106196
15	VRK1	1.79301516
16	LIMK1	1.76031444
17	TRIM28	1.75537315
18	STK39	1.75142306
19	BCKDK	1.62125749
20	ARAF	1.60909708
21	NEK1	1.51410090
22	DYRK3	1.50667804
23	TNIK	1.46638160
24	PLK4	1.46534849
25	DYRK2	1.44192586
26	SRPK1	1.38008246
27	CDK19	1.36472128
28	BRAF	1.34585837
29	MUSK	1.34052327
30	IRAK4	1.31331658
31	MKNK1	1.23029669
32	GRK7	1.22837534
33	MAP3K11	1.22477414
34	MAP2K7	1.21497844
35	DAPK1	1.18286880
36	ABL2	1.18033170
37	MKNK2	1.15952192
38	BRSK2	1.15899466
39	EPHB2	1.10765266
40	IRAK3	1.10398682
41	AURKA	1.10060351
42	PNCK	1.06830927
43	NUAK1	1.06656100
44	MAP3K12	1.06391618
45	CSNK1G2	1.05697148
46	MYLK	1.01209268
47	TESK1	0.98839229
48	MAP2K2	0.97083856
49	TSSK6	0.96093826
50	IRAK1	0.94488383
51	CSNK1G3	0.92143735
52	OXSR1	0.91825903
53	BLK	0.90505327
54	ZAK	0.90417552
55	MAPKAPK5	0.87918689
56	RPS6KA5	0.87657705
57	CLK1	0.85185020
58	TAF1	0.84025139
59	BCR	0.83930293
60	PLK1	0.82442596
61	IRAK2	0.82441333
62	DAPK3	0.80181288
63	ILK	0.80106456
64	KDR	0.78499284
65	ACVR1B	0.78341647
66	PAK1	0.76621363
67	PRKD3	0.74157841
68	AURKB	0.70736149
69	OBSCN	0.70246605
70	MINK1	0.70200733
71	RPS6KB2	0.68944003
72	CSNK2A1	0.68567089
73	EIF2AK2	0.67006728
74	GRK5	0.66951592
75	EPHA2	0.66126695
76	MAPKAPK3	0.65926999
77	CSNK2A2	0.65858445
78	CDK8	0.65151275
79	MAP4K2	0.64854728
80	PASK	0.64458410
81	WNK4	0.63391329
82	PHKG2	0.63359630
83	PHKG1	0.63359630
84	ATR	0.62772562
85	PINK1	0.62445550
86	TTK	0.61818410
87	MAPK15	0.59196753
88	CDK7	0.58085034
89	ADRBK2	0.57088895
90	CCNB1	0.56962062
91	AKT2	0.56552439
92	PRKCG	0.56549379
93	STK4	0.54833100
94	CDC7	0.54533916
95	CAMK2B	0.51420668
96	CAMK2G	0.50248417
97	CSNK1G1	0.48499978
98	TEC	0.48263646
99	SMG1	0.46522710
100	SCYL2	0.44166978
101	CDK11A	0.43860188
102	PAK4	0.43213550
103	IKBKB	0.42682467
104	MAP3K8	0.42560820
105	CAMK2D	0.42499868
106	MAPK4	0.42230016
107	ROCK2	0.41731967
108	BRSK1	0.41442181
109	GRK6	0.39235044
110	NLK	0.38982234
111	PRKCI	0.38728108
112	CSNK1A1	0.38317445
113	TAOK2	0.38050736
114	UHMK1	0.37680440
115	LRRK2	0.37335761
116	GRK1	0.35568290
117	CSNK1A1L	0.33843333
118	BMPR1B	0.33540373
119	CDK14	0.33340461
120	CDK15	0.33280802
121	CDK18	0.33156044
122	CHEK1	0.31190665
123	ZAP70	0.31110552
124	CHEK2	0.30333497
125	CASK	0.29124014
126	LYN	0.28441527
127	PLK3	0.28233046
128	ADRBK1	0.27775926
129	MAPKAPK2	0.27684393
130	MOS	0.27388196
131	INSRR	0.27048503
132	MAP4K1	0.26557498
133	PIK3CG	0.26346034
134	ERBB4	0.26046767
135	WNK3	0.24784367
136	CSNK1E	0.24294859

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.50404149
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.57815187
3	Proteasome_Homo sapiens_hsa03050	4.23879681
4	Parkinsons disease_Homo sapiens_hsa05012	4.03656639
5	RNA polymerase_Homo sapiens_hsa03020	3.78984599
6	Huntingtons disease_Homo sapiens_hsa05016	2.91096897
7	Alzheimers disease_Homo sapiens_hsa05010	2.79660931
8	DNA replication_Homo sapiens_hsa03030	2.64613677
9	Protein export_Homo sapiens_hsa03060	2.62757072
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.47321964
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.35641222
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.09714175
13	Mismatch repair_Homo sapiens_hsa03430	2.08042137
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.99463748
15	Spliceosome_Homo sapiens_hsa03040	1.98494114
16	Homologous recombination_Homo sapiens_hsa03440	1.71851069
17	Folate biosynthesis_Homo sapiens_hsa00790	1.68405110
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.68364200
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62182958
20	Fatty acid elongation_Homo sapiens_hsa00062	1.53964141
21	Base excision repair_Homo sapiens_hsa03410	1.50745106
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49145107
23	Sulfur relay system_Homo sapiens_hsa04122	1.45882535
24	Basal transcription factors_Homo sapiens_hsa03022	1.38983112
25	RNA transport_Homo sapiens_hsa03013	1.35306020
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.33491158
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32941486
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.29205952
29	Purine metabolism_Homo sapiens_hsa00230	1.27066946
30	Glutathione metabolism_Homo sapiens_hsa00480	1.18469195
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.17249122
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.17185861
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11040119
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02039935
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00995581
36	Metabolic pathways_Homo sapiens_hsa01100	0.93315356
37	Sulfur metabolism_Homo sapiens_hsa00920	0.91081616
38	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.88251776
39	RNA degradation_Homo sapiens_hsa03018	0.87651536
40	One carbon pool by folate_Homo sapiens_hsa00670	0.85923634
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84594086
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83012767
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82960467
44	Regulation of autophagy_Homo sapiens_hsa04140	0.82018845
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.78450605
46	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74893437
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74031262
48	Pentose phosphate pathway_Homo sapiens_hsa00030	0.72692298
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70892844
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70618587
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69801859
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69744838
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69269759
54	Carbon metabolism_Homo sapiens_hsa01200	0.65054151
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.63862397
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.63713557
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62835072
58	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.61995299
59	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61506873
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.61455493
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.61283713
62	Cell cycle_Homo sapiens_hsa04110	0.60069016
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59967051
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59416409
65	Peroxisome_Homo sapiens_hsa04146	0.59251813
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55021351
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.54122962
68	Fatty acid degradation_Homo sapiens_hsa00071	0.54112602
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54034830
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53978526
71	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.51634605
72	Histidine metabolism_Homo sapiens_hsa00340	0.49545087
73	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48370944
74	Propanoate metabolism_Homo sapiens_hsa00640	0.46686244
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46290696
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43687553
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43026681
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42089145
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.41133420
80	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40885737
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40334548
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38519024
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.37694817
84	p53 signaling pathway_Homo sapiens_hsa04115	0.36031495
85	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.33438939
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33043422
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.32750649
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.32614548
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32040147
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31617039
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30460780
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28933911
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.27957592
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.26858723
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.26668850
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25837691
97	Other glycan degradation_Homo sapiens_hsa00511	0.25266720
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24281260
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23341661
100	Phototransduction_Homo sapiens_hsa04744	0.21678497
101	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.19846245
102	Butanoate metabolism_Homo sapiens_hsa00650	0.19693828
103	Galactose metabolism_Homo sapiens_hsa00052	0.19666314
104	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.18147330
105	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.18082622
106	Allograft rejection_Homo sapiens_hsa05330	0.17648252
107	mRNA surveillance pathway_Homo sapiens_hsa03015	0.16097452
108	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.16043520
109	Retinol metabolism_Homo sapiens_hsa00830	0.15455851
110	Oocyte meiosis_Homo sapiens_hsa04114	0.15357599
111	Phagosome_Homo sapiens_hsa04145	0.15083971
112	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.13971673
113	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.13884410
114	Asthma_Homo sapiens_hsa05310	0.12664965
115	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.11759799
116	Primary immunodeficiency_Homo sapiens_hsa05340	0.10619374
117	Selenocompound metabolism_Homo sapiens_hsa00450	0.08009130
118	Graft-versus-host disease_Homo sapiens_hsa05332	0.07724804
119	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.07664764
120	Alcoholism_Homo sapiens_hsa05034	0.07253968

MRPL43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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