MRPL43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.62329706
2viral transcription (GO:0019083)6.60284546
3ribosomal small subunit biogenesis (GO:0042274)6.59513415
4translational termination (GO:0006415)6.41734198
5ribosomal small subunit assembly (GO:0000028)6.40865763
6ATP synthesis coupled proton transport (GO:0015986)6.40365398
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.40365398
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.77011126
9cotranslational protein targeting to membrane (GO:0006613)5.76848292
10protein targeting to ER (GO:0045047)5.69042364
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.53661618
12maturation of SSU-rRNA (GO:0030490)5.52839422
13translational elongation (GO:0006414)5.52471837
14protein localization to endoplasmic reticulum (GO:0070972)5.42740034
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.41660462
16ribosomal large subunit biogenesis (GO:0042273)5.23542143
17proteasome assembly (GO:0043248)5.23484540
18respiratory electron transport chain (GO:0022904)5.21614192
19viral life cycle (GO:0019058)5.10644995
20electron transport chain (GO:0022900)5.09868948
21cellular protein complex disassembly (GO:0043624)5.04716186
22translational initiation (GO:0006413)4.97036121
23DNA deamination (GO:0045006)4.81434355
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.69555056
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.69331552
26termination of RNA polymerase III transcription (GO:0006386)4.69331552
27* translation (GO:0006412)4.60996791
28chaperone-mediated protein transport (GO:0072321)4.60550419
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.29264458
30NADH dehydrogenase complex assembly (GO:0010257)4.29264458
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29264458
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.28244604
33protein complex disassembly (GO:0043241)4.28082421
34GTP biosynthetic process (GO:0006183)4.25285841
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.21747760
36protein neddylation (GO:0045116)4.21317495
37protein complex biogenesis (GO:0070271)4.12261413
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08930513
39macromolecular complex disassembly (GO:0032984)4.08366119
40ribonucleoprotein complex biogenesis (GO:0022613)4.07214957
41protein targeting to mitochondrion (GO:0006626)3.95103707
42mitochondrial respiratory chain complex assembly (GO:0033108)3.90797150
43establishment of protein localization to mitochondrion (GO:0072655)3.90171373
44cellular component biogenesis (GO:0044085)3.85753095
45protein targeting to membrane (GO:0006612)3.81799014
46negative regulation of ligase activity (GO:0051352)3.80527053
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.80527053
48regulation of cellular amino acid metabolic process (GO:0006521)3.79674085
49UTP biosynthetic process (GO:0006228)3.79437271
507-methylguanosine mRNA capping (GO:0006370)3.79239146
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77571263
52guanosine-containing compound biosynthetic process (GO:1901070)3.77196272
537-methylguanosine RNA capping (GO:0009452)3.73530113
54RNA capping (GO:0036260)3.73530113
55regulation of mitochondrial translation (GO:0070129)3.71373586
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67003342
57protein maturation by protein folding (GO:0022417)3.63839987
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61345415
59rRNA processing (GO:0006364)3.60739903
60L-methionine salvage (GO:0071267)3.59350978
61L-methionine biosynthetic process (GO:0071265)3.59350978
62amino acid salvage (GO:0043102)3.59350978
63protein localization to mitochondrion (GO:0070585)3.56265007
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.55039928
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53940380
66respiratory chain complex IV assembly (GO:0008535)3.53752341
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.52107651
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.52107651
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51508247
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51508247
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50711256
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49765550
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49765550
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49765550
75oxidative phosphorylation (GO:0006119)3.48141053
76rRNA metabolic process (GO:0016072)3.44808218
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44188572
78base-excision repair, AP site formation (GO:0006285)3.43732202
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42675158
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.42030060
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42030060
82cytochrome complex assembly (GO:0017004)3.41584798
83UTP metabolic process (GO:0046051)3.41386906
84cullin deneddylation (GO:0010388)3.41189298
85spliceosomal snRNP assembly (GO:0000387)3.39821957
86nuclear-transcribed mRNA catabolic process (GO:0000956)3.37462471
87purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36537653
88signal transduction involved in cell cycle checkpoint (GO:0072395)3.36048749
89inner mitochondrial membrane organization (GO:0007007)3.35735393
90rRNA modification (GO:0000154)3.35449001
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.34261110
92metallo-sulfur cluster assembly (GO:0031163)3.32890314
93iron-sulfur cluster assembly (GO:0016226)3.32890314
94formation of translation preinitiation complex (GO:0001731)3.32728621
95pseudouridine synthesis (GO:0001522)3.32430484
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.31264007
97CTP biosynthetic process (GO:0006241)3.29829879
98CTP metabolic process (GO:0046036)3.29829879
99establishment of integrated proviral latency (GO:0075713)3.24877483
100peptidyl-histidine modification (GO:0018202)3.24417931
101protein deneddylation (GO:0000338)3.23749528
102ATP biosynthetic process (GO:0006754)3.19072106
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.17100127
104mRNA catabolic process (GO:0006402)3.16992958
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16966112
106mitochondrial transport (GO:0006839)3.14538624
107ribonucleoside triphosphate biosynthetic process (GO:0009201)3.14121872
108nucleoside triphosphate biosynthetic process (GO:0009142)3.12998699
109positive regulation of ligase activity (GO:0051351)3.09660657
110DNA damage response, detection of DNA damage (GO:0042769)3.09075300
111hydrogen ion transmembrane transport (GO:1902600)3.02537117
112pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.01192080
113intracellular protein transmembrane import (GO:0044743)2.98814016
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96588282
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93042597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.88600392
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.65389433
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.41261874
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.26708041
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.18927497
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.05075096
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.93892819
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84135074
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.70597180
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59772361
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.55160545
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21435537
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.19524499
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13125100
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12799380
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01826585
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84263572
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71841461
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68929150
20VDR_23849224_ChIP-Seq_CD4+_Human2.68780032
21DCP1A_22483619_ChIP-Seq_HELA_Human2.64289116
22XRN2_22483619_ChIP-Seq_HELA_Human2.61602411
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42344566
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42024932
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.38617643
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28547348
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.16791654
28FOXP3_21729870_ChIP-Seq_TREG_Human2.16761728
29* GABP_19822575_ChIP-Seq_HepG2_Human2.03491320
30TTF2_22483619_ChIP-Seq_HELA_Human2.02614314
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02330380
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00010677
33* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87871008
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84661132
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84606638
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83423730
37E2F7_22180533_ChIP-Seq_HELA_Human1.83195826
38ELK1_19687146_ChIP-ChIP_HELA_Human1.83050195
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69919666
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69160847
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67573307
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66867552
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61745614
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.57810021
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50895946
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49946314
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47873855
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39773410
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38871322
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37277551
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34003391
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33714717
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32391025
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28302815
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26742628
56* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22168228
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21995367
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.21245805
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20291283
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19609740
61MYC_18940864_ChIP-ChIP_HL60_Human1.19025510
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17787569
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17719824
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16502513
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16494444
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16482516
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15401326
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11493813
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10902557
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08521456
71* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07805333
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06671070
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06313378
74IRF1_19129219_ChIP-ChIP_H3396_Human1.05859359
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04878787
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04757611
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00663336
78KDM5A_27292631_Chip-Seq_BREAST_Human0.99351265
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98336706
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96893828
81* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95498478
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93651612
83* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93015383
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92529183
85OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90458368
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89637701
87ZNF263_19887448_ChIP-Seq_K562_Human0.88448820
88SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88236291
89STAT1_20625510_ChIP-Seq_HELA_Human0.87937577
90TFEB_21752829_ChIP-Seq_HELA_Human0.87478517
91CIITA_25753668_ChIP-Seq_RAJI_Human0.86808237
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.86612543
93SPI1_23547873_ChIP-Seq_NB4_Human0.86343176
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85095708
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.84787630
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84484617
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84294894
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83744556
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82845187
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81580232
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81166935
102CTCF_26484167_Chip-Seq_Bcells_Mouse0.81053590
103FOXP1_21924763_ChIP-Seq_HESCs_Human0.80905574
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80344145
105CTCF_20526341_ChIP-Seq_ESCs_Human0.78759520
106* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78370308
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78153768
108E2F1_21310950_ChIP-Seq_MCF-7_Human0.77627453
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77431285
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76272398
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73231850
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.71872816
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71771936
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71282918
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71155646
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70613296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.49252618
2MP0003693_abnormal_embryo_hatching3.91574506
3MP0003806_abnormal_nucleotide_metabolis3.52313652
4MP0010030_abnormal_orbit_morphology3.32778207
5MP0001529_abnormal_vocalization3.21266278
6MP0003186_abnormal_redox_activity3.20349909
7MP0003136_yellow_coat_color3.05360901
8MP0004957_abnormal_blastocyst_morpholog2.94922548
9MP0005451_abnormal_body_composition2.93444866
10MP0006036_abnormal_mitochondrial_physio2.91096274
11MP0008260_abnormal_autophagy2.41514767
12MP0008932_abnormal_embryonic_tissue2.37205538
13MP0001905_abnormal_dopamine_level2.27350382
14MP0006035_abnormal_mitochondrial_morpho2.15501506
15MP0002132_abnormal_respiratory_system2.12595532
16MP0003718_maternal_effect2.03586643
17MP0003950_abnormal_plasma_membrane1.91976922
18MP0004142_abnormal_muscle_tone1.84418314
19MP0004381_abnormal_hair_follicle1.82178076
20MP0005409_darkened_coat_color1.81274368
21MP0008058_abnormal_DNA_repair1.78887676
22MP0003077_abnormal_cell_cycle1.77336825
23MP0001986_abnormal_taste_sensitivity1.75765818
24MP0005394_taste/olfaction_phenotype1.71771342
25MP0005499_abnormal_olfactory_system1.71771342
26MP0000920_abnormal_myelination1.65780272
27MP0000049_abnormal_middle_ear1.64302955
28MP0003786_premature_aging1.62502045
29MP0010094_abnormal_chromosome_stability1.61604271
30MP0005075_abnormal_melanosome_morpholog1.61473991
31MP0009333_abnormal_splenocyte_physiolog1.59426761
32MP0000372_irregular_coat_pigmentation1.53894729
33MP0003111_abnormal_nucleus_morphology1.48945904
34MP0009840_abnormal_foam_cell1.41704213
35MP0003646_muscle_fatigue1.41663811
36MP0001727_abnormal_embryo_implantation1.40719287
37MP0008057_abnormal_DNA_replication1.39418127
38MP0003011_delayed_dark_adaptation1.34741175
39MP0006292_abnormal_olfactory_placode1.33055154
40MP0002148_abnormal_hypersensitivity_rea1.31220758
41MP0003315_abnormal_perineum_morphology1.30955893
42MP0001542_abnormal_bone_strength1.28748587
43MP0000490_abnormal_crypts_of1.27939855
44MP0005379_endocrine/exocrine_gland_phen1.27345146
45MP0000749_muscle_degeneration1.26729744
46MP0001293_anophthalmia1.26465677
47MP0001346_abnormal_lacrimal_gland1.23714922
48MP0002638_abnormal_pupillary_reflex1.23554312
49MP0006072_abnormal_retinal_apoptosis1.22890692
50MP0002160_abnormal_reproductive_system1.22022859
51MP0003221_abnormal_cardiomyocyte_apopto1.22008266
52MP0003656_abnormal_erythrocyte_physiolo1.21670768
53MP0000358_abnormal_cell_content/1.15319141
54MP0001984_abnormal_olfaction1.12290313
55MP0001764_abnormal_homeostasis1.06718386
56MP0002938_white_spotting1.06705682
57MP0005408_hypopigmentation1.06536962
58MP0005423_abnormal_somatic_nervous1.05013904
59MP0005174_abnormal_tail_pigmentation1.04155780
60MP0001188_hyperpigmentation1.04021421
61MP0002210_abnormal_sex_determination1.03573761
62MP0006276_abnormal_autonomic_nervous1.02038419
63MP0001485_abnormal_pinna_reflex0.97348117
64MP0002277_abnormal_respiratory_mucosa0.94270568
65MP0003942_abnormal_urinary_system0.91681452
66MP0005330_cardiomyopathy0.88581495
67MP0002653_abnormal_ependyma_morphology0.87883470
68MP0009785_altered_susceptibility_to0.87212734
69MP0000015_abnormal_ear_pigmentation0.87152831
70MP0004145_abnormal_muscle_electrophysio0.86488544
71MP0005266_abnormal_metabolism0.86167966
72MP0000026_abnormal_inner_ear0.85834410
73MP0002751_abnormal_autonomic_nervous0.85502393
74MP0002102_abnormal_ear_morphology0.84981462
75MP0002090_abnormal_vision0.84629237
76MP0002249_abnormal_larynx_morphology0.83706080
77MP0005636_abnormal_mineral_homeostasis0.83579536
78MP0005332_abnormal_amino_acid0.82652257
79MP0000313_abnormal_cell_death0.82541480
80MP0003121_genomic_imprinting0.82316200
81MP0002163_abnormal_gland_morphology0.81342484
82MP0003123_paternal_imprinting0.80855613
83MP0003941_abnormal_skin_development0.80706974
84MP0001730_embryonic_growth_arrest0.80270755
85MP0000631_abnormal_neuroendocrine_gland0.80029775
86MP0002736_abnormal_nociception_after0.79669543
87MP0000566_synostosis0.79548552
88MP0009053_abnormal_anal_canal0.79490444
89MP0005389_reproductive_system_phenotype0.78726005
90MP0008875_abnormal_xenobiotic_pharmacok0.78480672
91MP0002233_abnormal_nose_morphology0.78202808
92MP0008007_abnormal_cellular_replicative0.78145970
93MP0005501_abnormal_skin_physiology0.77618132
94MP0000762_abnormal_tongue_morphology0.77210969
95MP0000747_muscle_weakness0.76425047
96MP0001929_abnormal_gametogenesis0.76269368
97MP0003937_abnormal_limbs/digits/tail_de0.75982690
98MP0005670_abnormal_white_adipose0.75929505
99MP0005025_abnormal_response_to0.75594119
100MP0001145_abnormal_male_reproductive0.74304076
101MP0002752_abnormal_somatic_nervous0.73177447
102MP0002095_abnormal_skin_pigmentation0.72450591
103MP0003137_abnormal_impulse_conducting0.72112430
104MP0004742_abnormal_vestibular_system0.72020611
105MP0004019_abnormal_vitamin_homeostasis0.71700620
106MP0008789_abnormal_olfactory_epithelium0.71543586
107MP0000653_abnormal_sex_gland0.71441804
108MP0002723_abnormal_immune_serum0.70354082
109MP0005000_abnormal_immune_tolerance0.70333003
110MP0001661_extended_life_span0.70276286
111MP0003724_increased_susceptibility_to0.70268876
112MP0009250_abnormal_appendicular_skeleto0.69816527
113MP0000647_abnormal_sebaceous_gland0.69060951
114MP0001853_heart_inflammation0.69058138
115MP0002822_catalepsy0.68936106
116MP0001919_abnormal_reproductive_system0.68305216
117MP0008995_early_reproductive_senescence0.68046180
118MP0002837_dystrophic_cardiac_calcinosis0.68021601
119MP0003880_abnormal_central_pattern0.67388869
120MP0001968_abnormal_touch/_nociception0.67178995
121MP0000678_abnormal_parathyroid_gland0.67149630
122MP0005376_homeostasis/metabolism_phenot0.66138698
123MP0005551_abnormal_eye_electrophysiolog0.65269313
124MP0003119_abnormal_digestive_system0.64893958
125MP0005084_abnormal_gallbladder_morpholo0.64633279
126MP0003938_abnormal_ear_development0.64139647
127MP0002282_abnormal_trachea_morphology0.63713255
128MP0002111_abnormal_tail_morphology0.63579840
129MP0002876_abnormal_thyroid_physiology0.63302289
130MP0004133_heterotaxia0.62725285
131MP0002396_abnormal_hematopoietic_system0.62234742
132MP0002429_abnormal_blood_cell0.62131434
133MP0002019_abnormal_tumor_incidence0.61480151
134MP0000750_abnormal_muscle_regeneration0.61351759
135MP0005410_abnormal_fertilization0.61346366
136MP0003567_abnormal_fetal_cardiomyocyte0.60722413
137MP0005381_digestive/alimentary_phenotyp0.60598341
138MP0001663_abnormal_digestive_system0.59780289
139MP0008873_increased_physiological_sensi0.58891520
140MP0000689_abnormal_spleen_morphology0.58251933
141MP0005671_abnormal_response_to0.57686004
142MP0008469_abnormal_protein_level0.57309936
143MP0004147_increased_porphyrin_level0.57257484
144MP0005083_abnormal_biliary_tract0.56918001
145MP0002229_neurodegeneration0.56204090
146MP0002722_abnormal_immune_system0.55854097
147MP0004036_abnormal_muscle_relaxation0.54822189
148MP0002420_abnormal_adaptive_immunity0.54667129

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.02634162
2Abnormal mitochondria in muscle tissue (HP:0008316)5.55397514
3Mitochondrial inheritance (HP:0001427)5.51561401
4Abnormality of cells of the erythroid lineage (HP:0012130)5.39989882
5Acute encephalopathy (HP:0006846)5.11317400
6Hepatocellular necrosis (HP:0001404)5.11107668
7Abnormal number of erythroid precursors (HP:0012131)4.92447102
8Increased CSF lactate (HP:0002490)4.79877186
9Progressive macrocephaly (HP:0004481)4.79465798
10Increased hepatocellular lipid droplets (HP:0006565)4.66131034
11Hepatic necrosis (HP:0002605)4.59437462
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.54452509
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.54452509
14Reticulocytopenia (HP:0001896)4.41337838
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.35596526
16Lipid accumulation in hepatocytes (HP:0006561)4.25254454
17Cerebral hypomyelination (HP:0006808)4.15833757
18Abnormality of glycolysis (HP:0004366)4.13007848
19Increased serum pyruvate (HP:0003542)4.13007848
20Renal Fanconi syndrome (HP:0001994)4.09456927
213-Methylglutaconic aciduria (HP:0003535)4.03841810
22Macrocytic anemia (HP:0001972)3.96246526
23Increased intramyocellular lipid droplets (HP:0012240)3.94249113
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.93288727
25Increased serum lactate (HP:0002151)3.80151841
26Cerebral edema (HP:0002181)3.63733427
27Respiratory failure (HP:0002878)3.53552597
28Exertional dyspnea (HP:0002875)3.49043870
29Lactic acidosis (HP:0003128)3.48747405
30Exercise intolerance (HP:0003546)3.46601988
31Leukodystrophy (HP:0002415)3.44329955
32Increased muscle lipid content (HP:0009058)3.42442082
33Pallor (HP:0000980)3.19660883
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.10408422
35Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08655608
36Optic disc pallor (HP:0000543)2.94807127
37Respiratory difficulties (HP:0002880)2.74245294
38CNS demyelination (HP:0007305)2.72649587
39Degeneration of anterior horn cells (HP:0002398)2.71942351
40Abnormality of the anterior horn cell (HP:0006802)2.71942351
41Hyperglycinemia (HP:0002154)2.66528257
42Abnormality of renal resorption (HP:0011038)2.61165776
43Parakeratosis (HP:0001036)2.49586611
44Lethargy (HP:0001254)2.42807291
45Emotional lability (HP:0000712)2.41471548
46Type I transferrin isoform profile (HP:0003642)2.37258638
47Congenital ichthyosiform erythroderma (HP:0007431)2.36618088
48Adrenal hypoplasia (HP:0000835)2.35206402
49CNS hypomyelination (HP:0003429)2.32991616
50Spastic paraparesis (HP:0002313)2.29853726
51Oral leukoplakia (HP:0002745)2.24247294
52Aplastic anemia (HP:0001915)2.21539485
53Rough bone trabeculation (HP:0100670)2.19605785
54Amniotic constriction ring (HP:0009775)2.19517830
55Abnormality of placental membranes (HP:0011409)2.19517830
56Testicular atrophy (HP:0000029)2.19222536
57Breast hypoplasia (HP:0003187)2.16583715
58Glycosuria (HP:0003076)2.15442406
59Abnormality of urine glucose concentration (HP:0011016)2.15442406
60Hyperphosphaturia (HP:0003109)2.15246878
61Myokymia (HP:0002411)2.13990980
62Microvesicular hepatic steatosis (HP:0001414)2.10168771
63Multiple enchondromatosis (HP:0005701)2.08353963
64Double outlet right ventricle (HP:0001719)2.07176157
65Congenital malformation of the right heart (HP:0011723)2.07176157
66Opisthotonus (HP:0002179)2.04685139
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04504566
68Abnormality of alanine metabolism (HP:0010916)2.04504566
69Hyperalaninemia (HP:0003348)2.04504566
70Generalized aminoaciduria (HP:0002909)2.01659388
71Abnormal pupillary function (HP:0007686)2.00757797
72Ragged-red muscle fibers (HP:0003200)1.97470045
73Sclerocornea (HP:0000647)1.92376871
74Secondary amenorrhea (HP:0000869)1.92233780
75Delusions (HP:0000746)1.91504040
76Abnormal hemoglobin (HP:0011902)1.91343208
77Postnatal microcephaly (HP:0005484)1.90527604
78Molar tooth sign on MRI (HP:0002419)1.87582718
79Abnormality of midbrain morphology (HP:0002418)1.87582718
80Hypokinesia (HP:0002375)1.86859707
81Hypoplasia of the uterus (HP:0000013)1.83053169
82Abnormality of glycine metabolism (HP:0010895)1.82006688
83Abnormality of serine family amino acid metabolism (HP:0010894)1.82006688
84Hypoplastic left heart (HP:0004383)1.81377743
85Pancytopenia (HP:0001876)1.80616599
86Facial cleft (HP:0002006)1.80417094
87Hyperglycinuria (HP:0003108)1.79574222
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78619322
89Abnormal protein N-linked glycosylation (HP:0012347)1.78619322
90Abnormal protein glycosylation (HP:0012346)1.78619322
91Abnormal glycosylation (HP:0012345)1.78619322
92Muscle fiber atrophy (HP:0100295)1.78269228
93Abnormal urine phosphate concentration (HP:0012599)1.77655283
94Progressive muscle weakness (HP:0003323)1.77070095
95Methylmalonic aciduria (HP:0012120)1.76978197
96Birth length less than 3rd percentile (HP:0003561)1.76653038
97Abnormality of serum amino acid levels (HP:0003112)1.76501593
98Pancreatic fibrosis (HP:0100732)1.76318522
99Abnormality of the labia minora (HP:0012880)1.76287140
100Hepatosplenomegaly (HP:0001433)1.76251865
101Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76070042
102Dicarboxylic aciduria (HP:0003215)1.76070042
103Neuroendocrine neoplasm (HP:0100634)1.74985704
104Aplasia/hypoplasia of the uterus (HP:0008684)1.74797565
105Reduced antithrombin III activity (HP:0001976)1.74534702
106Asplenia (HP:0001746)1.70665758
107Prolonged neonatal jaundice (HP:0006579)1.70562092
108Abnormality of the umbilical cord (HP:0010881)1.69557483
109Abnormal umbilical cord blood vessels (HP:0011403)1.69494933
110Single umbilical artery (HP:0001195)1.69494933
111Abnormality of the fetal cardiovascular system (HP:0010948)1.69494933
112Blindness (HP:0000618)1.68667412
113X-linked dominant inheritance (HP:0001423)1.68271961
114Microretrognathia (HP:0000308)1.67317951
115True hermaphroditism (HP:0010459)1.66152237
116Abnormal trabecular bone morphology (HP:0100671)1.65460761
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64882866
118Gliosis (HP:0002171)1.64852598
119Carpal bone hypoplasia (HP:0001498)1.62848345
120Trismus (HP:0000211)1.62828676
121Occipital encephalocele (HP:0002085)1.62065564
122Premature ovarian failure (HP:0008209)1.61650221
123Sensory axonal neuropathy (HP:0003390)1.61368591
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60167902
125Poor suck (HP:0002033)1.60133009
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59655460
127Stenosis of the external auditory canal (HP:0000402)1.54746940
128Abnormalities of placenta or umbilical cord (HP:0001194)1.54718915
129Type 2 muscle fiber atrophy (HP:0003554)1.53870919
130Unsteady gait (HP:0002317)1.53693505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.10088852
2NME24.74630509
3BUB14.19930177
4STK164.03463380
5TLK13.55497688
6EIF2AK13.43312896
7NME13.16997222
8PBK2.86281115
9WEE12.74727608
10MST42.45523692
11PDK22.31103213
12TESK22.23395759
13EIF2AK32.04541867
14PIM22.01106196
15VRK11.79301516
16LIMK11.76031444
17TRIM281.75537315
18STK391.75142306
19BCKDK1.62125749
20ARAF1.60909708
21NEK11.51410090
22DYRK31.50667804
23TNIK1.46638160
24PLK41.46534849
25DYRK21.44192586
26SRPK11.38008246
27CDK191.36472128
28BRAF1.34585837
29MUSK1.34052327
30IRAK41.31331658
31MKNK11.23029669
32GRK71.22837534
33MAP3K111.22477414
34MAP2K71.21497844
35DAPK11.18286880
36ABL21.18033170
37MKNK21.15952192
38BRSK21.15899466
39EPHB21.10765266
40IRAK31.10398682
41AURKA1.10060351
42PNCK1.06830927
43NUAK11.06656100
44MAP3K121.06391618
45CSNK1G21.05697148
46MYLK1.01209268
47TESK10.98839229
48MAP2K20.97083856
49TSSK60.96093826
50IRAK10.94488383
51CSNK1G30.92143735
52OXSR10.91825903
53BLK0.90505327
54ZAK0.90417552
55MAPKAPK50.87918689
56RPS6KA50.87657705
57CLK10.85185020
58TAF10.84025139
59BCR0.83930293
60PLK10.82442596
61IRAK20.82441333
62DAPK30.80181288
63ILK0.80106456
64KDR0.78499284
65ACVR1B0.78341647
66PAK10.76621363
67PRKD30.74157841
68AURKB0.70736149
69OBSCN0.70246605
70MINK10.70200733
71RPS6KB20.68944003
72CSNK2A10.68567089
73EIF2AK20.67006728
74GRK50.66951592
75EPHA20.66126695
76MAPKAPK30.65926999
77CSNK2A20.65858445
78CDK80.65151275
79MAP4K20.64854728
80PASK0.64458410
81WNK40.63391329
82PHKG10.63359630
83PHKG20.63359630
84ATR0.62772562
85PINK10.62445550
86TTK0.61818410
87MAPK150.59196753
88CDK70.58085034
89ADRBK20.57088895
90CCNB10.56962062
91AKT20.56552439
92PRKCG0.56549379
93STK40.54833100
94CDC70.54533916
95CAMK2B0.51420668
96CAMK2G0.50248417
97CSNK1G10.48499978
98TEC0.48263646
99SMG10.46522710
100SCYL20.44166978
101CDK11A0.43860188
102PAK40.43213550
103IKBKB0.42682467
104MAP3K80.42560820
105CAMK2D0.42499868
106MAPK40.42230016
107ROCK20.41731967
108BRSK10.41442181
109GRK60.39235044
110NLK0.38982234
111PRKCI0.38728108
112CSNK1A10.38317445
113TAOK20.38050736
114UHMK10.37680440
115LRRK20.37335761
116GRK10.35568290
117CSNK1A1L0.33843333
118BMPR1B0.33540373
119CDK140.33340461
120CDK150.33280802
121CDK180.33156044
122CHEK10.31190665
123ZAP700.31110552
124CHEK20.30333497
125CASK0.29124014
126LYN0.28441527
127PLK30.28233046
128ADRBK10.27775926
129MAPKAPK20.27684393
130MOS0.27388196
131INSRR0.27048503
132MAP4K10.26557498
133PIK3CG0.26346034
134ERBB40.26046767
135WNK30.24784367
136CSNK1E0.24294859

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.50404149
2Oxidative phosphorylation_Homo sapiens_hsa001904.57815187
3Proteasome_Homo sapiens_hsa030504.23879681
4Parkinsons disease_Homo sapiens_hsa050124.03656639
5RNA polymerase_Homo sapiens_hsa030203.78984599
6Huntingtons disease_Homo sapiens_hsa050162.91096897
7Alzheimers disease_Homo sapiens_hsa050102.79660931
8DNA replication_Homo sapiens_hsa030302.64613677
9Protein export_Homo sapiens_hsa030602.62757072
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47321964
11Pyrimidine metabolism_Homo sapiens_hsa002402.35641222
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09714175
13Mismatch repair_Homo sapiens_hsa034302.08042137
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99463748
15Spliceosome_Homo sapiens_hsa030401.98494114
16Homologous recombination_Homo sapiens_hsa034401.71851069
17Folate biosynthesis_Homo sapiens_hsa007901.68405110
18Nucleotide excision repair_Homo sapiens_hsa034201.68364200
19Cardiac muscle contraction_Homo sapiens_hsa042601.62182958
20Fatty acid elongation_Homo sapiens_hsa000621.53964141
21Base excision repair_Homo sapiens_hsa034101.50745106
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49145107
23Sulfur relay system_Homo sapiens_hsa041221.45882535
24Basal transcription factors_Homo sapiens_hsa030221.38983112
25RNA transport_Homo sapiens_hsa030131.35306020
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33491158
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32941486
28Vitamin B6 metabolism_Homo sapiens_hsa007501.29205952
29Purine metabolism_Homo sapiens_hsa002301.27066946
30Glutathione metabolism_Homo sapiens_hsa004801.18469195
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17249122
32Steroid biosynthesis_Homo sapiens_hsa001001.17185861
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11040119
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02039935
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00995581
36Metabolic pathways_Homo sapiens_hsa011000.93315356
37Sulfur metabolism_Homo sapiens_hsa009200.91081616
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88251776
39RNA degradation_Homo sapiens_hsa030180.87651536
40One carbon pool by folate_Homo sapiens_hsa006700.85923634
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84594086
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.83012767
43Arachidonic acid metabolism_Homo sapiens_hsa005900.82960467
44Regulation of autophagy_Homo sapiens_hsa041400.82018845
45Non-homologous end-joining_Homo sapiens_hsa034500.78450605
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74893437
47Fanconi anemia pathway_Homo sapiens_hsa034600.74031262
48Pentose phosphate pathway_Homo sapiens_hsa000300.72692298
49Arginine and proline metabolism_Homo sapiens_hsa003300.70892844
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.70618587
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.69801859
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69744838
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.69269759
54Carbon metabolism_Homo sapiens_hsa012000.65054151
55Pyruvate metabolism_Homo sapiens_hsa006200.63862397
56Fatty acid metabolism_Homo sapiens_hsa012120.63713557
57Collecting duct acid secretion_Homo sapiens_hsa049660.62835072
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61995299
59Epstein-Barr virus infection_Homo sapiens_hsa051690.61506873
60Ether lipid metabolism_Homo sapiens_hsa005650.61455493
61Vibrio cholerae infection_Homo sapiens_hsa051100.61283713
62Cell cycle_Homo sapiens_hsa041100.60069016
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59967051
64Systemic lupus erythematosus_Homo sapiens_hsa053220.59416409
65Peroxisome_Homo sapiens_hsa041460.59251813
66Sphingolipid metabolism_Homo sapiens_hsa006000.55021351
67Linoleic acid metabolism_Homo sapiens_hsa005910.54122962
68Fatty acid degradation_Homo sapiens_hsa000710.54112602
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54034830
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53978526
71Biosynthesis of amino acids_Homo sapiens_hsa012300.51634605
72Histidine metabolism_Homo sapiens_hsa003400.49545087
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48370944
74Propanoate metabolism_Homo sapiens_hsa006400.46686244
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46290696
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43687553
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43026681
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.42089145
79Tyrosine metabolism_Homo sapiens_hsa003500.41133420
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40885737
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40334548
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38519024
83Tryptophan metabolism_Homo sapiens_hsa003800.37694817
84p53 signaling pathway_Homo sapiens_hsa041150.36031495
85Fructose and mannose metabolism_Homo sapiens_hsa000510.33438939
86Rheumatoid arthritis_Homo sapiens_hsa053230.33043422
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32750649
88Basal cell carcinoma_Homo sapiens_hsa052170.32614548
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32040147
90Phenylalanine metabolism_Homo sapiens_hsa003600.31617039
91Synaptic vesicle cycle_Homo sapiens_hsa047210.30460780
92Chemical carcinogenesis_Homo sapiens_hsa052040.28933911
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27957592
94Fat digestion and absorption_Homo sapiens_hsa049750.26858723
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26668850
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25837691
97Other glycan degradation_Homo sapiens_hsa005110.25266720
98beta-Alanine metabolism_Homo sapiens_hsa004100.24281260
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23341661
100Phototransduction_Homo sapiens_hsa047440.21678497
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19846245
102Butanoate metabolism_Homo sapiens_hsa006500.19693828
103Galactose metabolism_Homo sapiens_hsa000520.19666314
104Autoimmune thyroid disease_Homo sapiens_hsa053200.18147330
105N-Glycan biosynthesis_Homo sapiens_hsa005100.18082622
106Allograft rejection_Homo sapiens_hsa053300.17648252
107mRNA surveillance pathway_Homo sapiens_hsa030150.16097452
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16043520
109Retinol metabolism_Homo sapiens_hsa008300.15455851
110Oocyte meiosis_Homo sapiens_hsa041140.15357599
111Phagosome_Homo sapiens_hsa041450.15083971
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13971673
113Hedgehog signaling pathway_Homo sapiens_hsa043400.13884410
114Asthma_Homo sapiens_hsa053100.12664965
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11759799
116Primary immunodeficiency_Homo sapiens_hsa053400.10619374
117Selenocompound metabolism_Homo sapiens_hsa004500.08009130
118Graft-versus-host disease_Homo sapiens_hsa053320.07724804
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07664764
120Alcoholism_Homo sapiens_hsa050340.07253968

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