MRPL44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.07638158
2DNA deamination (GO:0045006)4.88126067
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.65796560
4nucleobase biosynthetic process (GO:0046112)4.58324240
5purine nucleobase biosynthetic process (GO:0009113)4.50973059
6proteasome assembly (GO:0043248)4.44043441
7formation of translation preinitiation complex (GO:0001731)4.36764094
8DNA strand elongation involved in DNA replication (GO:0006271)4.22027999
9DNA damage response, detection of DNA damage (GO:0042769)4.21399598
10telomere maintenance via semi-conservative replication (GO:0032201)4.20895786
11maturation of SSU-rRNA (GO:0030490)4.18024412
12DNA strand elongation (GO:0022616)4.02510998
13chaperone-mediated protein transport (GO:0072321)4.01134915
14establishment of integrated proviral latency (GO:0075713)3.90193076
15DNA replication initiation (GO:0006270)3.84269499
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83419487
17ribosome biogenesis (GO:0042254)3.81026852
18telomere maintenance via recombination (GO:0000722)3.75287848
19DNA replication checkpoint (GO:0000076)3.72436598
20ribosomal large subunit biogenesis (GO:0042273)3.70534958
21oxidative phosphorylation (GO:0006119)3.70266537
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69367686
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67084472
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62942152
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61958476
26ribonucleoprotein complex biogenesis (GO:0022613)3.61566978
27pseudouridine synthesis (GO:0001522)3.60792206
28protein deneddylation (GO:0000338)3.57679128
29regulation of helicase activity (GO:0051095)3.57453623
30CENP-A containing nucleosome assembly (GO:0034080)3.56910767
31rRNA modification (GO:0000154)3.56806952
32mitotic metaphase plate congression (GO:0007080)3.56545258
33cullin deneddylation (GO:0010388)3.55173365
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53207400
35mitotic recombination (GO:0006312)3.53009529
36viral transcription (GO:0019083)3.50662311
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50457672
38regulation of mitotic spindle checkpoint (GO:1903504)3.50457672
39translational termination (GO:0006415)3.48253441
40viral mRNA export from host cell nucleus (GO:0046784)3.47292927
41termination of RNA polymerase III transcription (GO:0006386)3.46892041
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.46892041
43telomere maintenance via telomere lengthening (GO:0010833)3.45874211
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42668074
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42622088
46negative regulation of ligase activity (GO:0051352)3.42552818
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42552818
48IMP biosynthetic process (GO:0006188)3.42468239
49mitochondrial RNA metabolic process (GO:0000959)3.42097007
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.41393303
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41393303
52chromatin remodeling at centromere (GO:0031055)3.40442708
53spliceosomal snRNP assembly (GO:0000387)3.38344490
54ribosome assembly (GO:0042255)3.37837069
55regulation of cellular amino acid metabolic process (GO:0006521)3.37120704
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36626290
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36626290
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34436261
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34436261
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34436261
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.32898789
62rRNA processing (GO:0006364)3.32659149
63ATP synthesis coupled proton transport (GO:0015986)3.32570707
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32570707
65protein neddylation (GO:0045116)3.32101367
66* translational elongation (GO:0006414)3.31476557
67regulation of mitochondrial translation (GO:0070129)3.30953781
68ribosomal small subunit biogenesis (GO:0042274)3.28485193
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27333189
70transcription-coupled nucleotide-excision repair (GO:0006283)3.26917385
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26690470
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.26344654
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26344654
74establishment of viral latency (GO:0019043)3.25828260
75cellular component biogenesis (GO:0044085)3.24697779
767-methylguanosine mRNA capping (GO:0006370)3.24595750
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23127806
78translational initiation (GO:0006413)3.22647039
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.21417334
80rRNA metabolic process (GO:0016072)3.21192461
81translation (GO:0006412)3.20248954
82spindle checkpoint (GO:0031577)3.20114948
83transcription from mitochondrial promoter (GO:0006390)3.19905808
84DNA unwinding involved in DNA replication (GO:0006268)3.19637096
85cotranslational protein targeting to membrane (GO:0006613)3.19317391
86maturation of 5.8S rRNA (GO:0000460)3.18685439
87DNA double-strand break processing (GO:0000729)3.17891961
88mitotic spindle checkpoint (GO:0071174)3.16081294
897-methylguanosine RNA capping (GO:0009452)3.15185261
90RNA capping (GO:0036260)3.15185261
91protein targeting to ER (GO:0045047)3.14968749
92DNA catabolic process, exonucleolytic (GO:0000738)3.14314960
93protein targeting to mitochondrion (GO:0006626)3.11280312
94positive regulation of ligase activity (GO:0051351)3.10820232
95histone exchange (GO:0043486)3.10324785
96IMP metabolic process (GO:0046040)3.10146175
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09853838
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09853838
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.09766858
100histone mRNA metabolic process (GO:0008334)3.09490452
101nucleobase-containing small molecule interconversion (GO:0015949)3.06899323
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06089486
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05604506
104DNA replication-independent nucleosome organization (GO:0034724)3.04899269
105DNA replication-independent nucleosome assembly (GO:0006336)3.04899269
106metaphase plate congression (GO:0051310)3.03960004
107regulation of ubiquitin-protein transferase activity (GO:0051438)3.03767061
108protein localization to kinetochore (GO:0034501)3.03611689
109protein localization to endoplasmic reticulum (GO:0070972)3.02557800
110mitochondrial respiratory chain complex I assembly (GO:0032981)3.02234653
111NADH dehydrogenase complex assembly (GO:0010257)3.02234653
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02234653
113cell cycle G1/S phase transition (GO:0044843)3.00477977
114G1/S transition of mitotic cell cycle (GO:0000082)3.00477977
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.00329251
116negative regulation of sister chromatid segregation (GO:0033046)3.00329251
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00329251
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00329251
119negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00329251
120protein K6-linked ubiquitination (GO:0085020)2.99543542
121protein localization to mitochondrion (GO:0070585)2.99459944
122DNA replication-dependent nucleosome assembly (GO:0006335)2.99185366
123DNA replication-dependent nucleosome organization (GO:0034723)2.99185366
124respiratory chain complex IV assembly (GO:0008535)2.96847762
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96604967
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95958007
127rRNA methylation (GO:0031167)2.95215715
128regulation of ligase activity (GO:0051340)2.94510738
129L-methionine salvage (GO:0071267)2.94248948
130L-methionine biosynthetic process (GO:0071265)2.94248948
131amino acid salvage (GO:0043102)2.94248948
132mitochondrial respiratory chain complex assembly (GO:0033108)2.93540374
133piRNA metabolic process (GO:0034587)2.92955566
134negative regulation of chromosome segregation (GO:0051985)2.92818422
135folic acid metabolic process (GO:0046655)2.92731908
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92142835
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91883751
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91883751
139isotype switching (GO:0045190)2.91883751
140establishment of protein localization to mitochondrion (GO:0072655)2.91214912
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.88453718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.93710207
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.27230841
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06044353
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96213526
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64461119
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.55142135
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.53165237
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.21984111
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09834456
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08517016
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07938566
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94179938
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84654675
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82366524
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63600903
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62831698
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61183014
18* VDR_23849224_ChIP-Seq_CD4+_Human2.50245001
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41903907
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.34668794
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34312401
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32951942
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32366158
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.28301193
25XRN2_22483619_ChIP-Seq_HELA_Human2.27027475
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26928428
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.26467381
28* SRF_21415370_ChIP-Seq_HL-1_Mouse2.22117655
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16951086
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13305523
31* GABP_19822575_ChIP-Seq_HepG2_Human2.08820812
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04809652
33* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04079189
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03840295
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.03730684
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98658275
37ZNF274_21170338_ChIP-Seq_K562_Hela1.88119242
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79754529
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77637980
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75162564
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75035600
42TTF2_22483619_ChIP-Seq_HELA_Human1.74533557
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71730325
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70589901
45ELK1_19687146_ChIP-ChIP_HELA_Human1.68134158
46AR_21909140_ChIP-Seq_LNCAP_Human1.65133192
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63283529
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63191091
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62490967
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61070665
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60908955
52CIITA_25753668_ChIP-Seq_RAJI_Human1.58853749
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58026420
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.56808892
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56080252
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48604299
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.46579186
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42011893
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41351779
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36644841
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36091320
62IRF1_19129219_ChIP-ChIP_H3396_Human1.34266003
63EWS_26573619_Chip-Seq_HEK293_Human1.32530302
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.30794052
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.28935569
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28232868
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.25307839
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.22927393
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22556612
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21567644
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18007594
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16909921
73* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16449252
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16437387
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16339190
76IGF1R_20145208_ChIP-Seq_DFB_Human1.16149329
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14134734
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13335432
79TFEB_21752829_ChIP-Seq_HELA_Human1.11654559
80* SPI1_23547873_ChIP-Seq_NB4_Human1.10446995
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08126911
82* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08048367
83* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07594347
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07250903
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06492308
86* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05690209
87MYC_18940864_ChIP-ChIP_HL60_Human1.05424408
88MYC_22102868_ChIP-Seq_BL_Human1.01576426
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01372660
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01291524
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.00559834
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99395019
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98634790
94FUS_26573619_Chip-Seq_HEK293_Human0.97804224
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97472795
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93403163
97* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90770557
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89246296
99VDR_22108803_ChIP-Seq_LS180_Human0.88029084
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.87242242
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86984586
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85637033
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85637033
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85637033
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85261651
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84236289
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82144188
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81766822
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78600330
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78578971
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78209585
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77972921
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77498945
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77172034
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.74964626
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74203439
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74089407
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73909952
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72638573
120* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70711985
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70586413
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70491710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41672790
2MP0010094_abnormal_chromosome_stability4.12320610
3MP0004957_abnormal_blastocyst_morpholog4.11407105
4MP0003111_abnormal_nucleus_morphology3.76117911
5MP0003077_abnormal_cell_cycle3.49746743
6MP0008058_abnormal_DNA_repair3.34295586
7MP0002396_abnormal_hematopoietic_system2.84045593
8MP0003806_abnormal_nucleotide_metabolis2.78948823
9MP0006036_abnormal_mitochondrial_physio2.77122469
10MP0008057_abnormal_DNA_replication2.65710694
11MP0003186_abnormal_redox_activity2.58770884
12MP0008007_abnormal_cellular_replicative2.58461973
13MP0003646_muscle_fatigue2.39929287
14MP0003136_yellow_coat_color2.18337418
15MP0003786_premature_aging2.17674050
16MP0008932_abnormal_embryonic_tissue2.16139110
17MP0001529_abnormal_vocalization1.99672700
18MP0006035_abnormal_mitochondrial_morpho1.97330952
19MP0008877_abnormal_DNA_methylation1.95959377
20MP0001764_abnormal_homeostasis1.92706750
21MP0002102_abnormal_ear_morphology1.91443449
22MP0008789_abnormal_olfactory_epithelium1.89528912
23MP0003123_paternal_imprinting1.85522701
24MP0003221_abnormal_cardiomyocyte_apopto1.84687041
25MP0003890_abnormal_embryonic-extraembry1.84182310
26MP0001730_embryonic_growth_arrest1.78687326
27MP0003718_maternal_effect1.77855958
28MP0005075_abnormal_melanosome_morpholog1.73492375
29MP0003195_calcinosis1.65670891
30MP0000490_abnormal_crypts_of1.59632373
31MP0005397_hematopoietic_system_phenotyp1.55870157
32MP0001545_abnormal_hematopoietic_system1.55870157
33MP0001853_heart_inflammation1.55686069
34MP0002132_abnormal_respiratory_system1.55519351
35MP0003941_abnormal_skin_development1.55332998
36MP0002139_abnormal_hepatobiliary_system1.54754564
37MP0000350_abnormal_cell_proliferation1.50556639
38MP0009333_abnormal_splenocyte_physiolog1.50230254
39MP0004084_abnormal_cardiac_muscle1.45948327
40MP0009697_abnormal_copulation1.45922391
41MP0005394_taste/olfaction_phenotype1.43361056
42MP0005499_abnormal_olfactory_system1.43361056
43MP0003763_abnormal_thymus_physiology1.39658647
44MP0003567_abnormal_fetal_cardiomyocyte1.38335464
45MP0004808_abnormal_hematopoietic_stem1.36585711
46MP0002019_abnormal_tumor_incidence1.35164174
47MP0000313_abnormal_cell_death1.34633006
48MP0002938_white_spotting1.27583104
49MP0004147_increased_porphyrin_level1.25428415
50MP0002277_abnormal_respiratory_mucosa1.22127400
51MP0002254_reproductive_system_inflammat1.20360653
52MP0002080_prenatal_lethality1.19256095
53MP0002138_abnormal_hepatobiliary_system1.18499578
54MP0000358_abnormal_cell_content/1.18372088
55MP0002163_abnormal_gland_morphology1.18188994
56MP0005084_abnormal_gallbladder_morpholo1.17929417
57MP0001324_abnormal_eye_pigmentation1.17850565
58MP0005380_embryogenesis_phenotype1.17835775
59MP0001672_abnormal_embryogenesis/_devel1.17835775
60MP0005266_abnormal_metabolism1.16466055
61MP0001835_abnormal_antigen_presentation1.15849110
62MP0001697_abnormal_embryo_size1.15757758
63MP0000689_abnormal_spleen_morphology1.15104393
64MP0003984_embryonic_growth_retardation1.15085145
65MP0005330_cardiomyopathy1.15053279
66MP0005395_other_phenotype1.14677387
67MP0003011_delayed_dark_adaptation1.12416005
68MP0002837_dystrophic_cardiac_calcinosis1.11602962
69MP0002398_abnormal_bone_marrow1.09841799
70MP0001986_abnormal_taste_sensitivity1.09608055
71MP0004215_abnormal_myocardial_fiber1.09374932
72MP0008260_abnormal_autophagy1.09330251
73MP0002088_abnormal_embryonic_growth/wei1.08782176
74MP0008995_early_reproductive_senescence1.07358102
75MP0002722_abnormal_immune_system1.07064889
76MP0006072_abnormal_retinal_apoptosis1.06014892
77MP0009785_altered_susceptibility_to1.04992305
78MP0009379_abnormal_foot_pigmentation1.03267059
79MP0008875_abnormal_xenobiotic_pharmacok0.99965284
80MP0006292_abnormal_olfactory_placode0.97207705
81MP0002429_abnormal_blood_cell0.95931774
82MP0002822_catalepsy0.94387142
83MP0005319_abnormal_enzyme/_coenzyme0.93815815
84MP0000647_abnormal_sebaceous_gland0.93580051
85MP0005451_abnormal_body_composition0.93468026
86MP0000703_abnormal_thymus_morphology0.93059928
87MP0000749_muscle_degeneration0.92505589
88MP0005379_endocrine/exocrine_gland_phen0.92442036
89MP0002751_abnormal_autonomic_nervous0.91537106
90MP0002084_abnormal_developmental_patter0.90634413
91MP0004133_heterotaxia0.88112837
92MP0005645_abnormal_hypothalamus_physiol0.87242431
93MP0002210_abnormal_sex_determination0.85800448
94MP0002736_abnormal_nociception_after0.84687387
95MP0001727_abnormal_embryo_implantation0.84675146
96MP0003315_abnormal_perineum_morphology0.83659962
97MP0002090_abnormal_vision0.83456998
98MP0000015_abnormal_ear_pigmentation0.83385445
99MP0000631_abnormal_neuroendocrine_gland0.83147145
100MP0002095_abnormal_skin_pigmentation0.83040266
101MP0003119_abnormal_digestive_system0.82667553
102MP0000049_abnormal_middle_ear0.82381158
103MP0001119_abnormal_female_reproductive0.81773823
104MP0005332_abnormal_amino_acid0.81702972
105MP0000716_abnormal_immune_system0.81236312
106MP0003121_genomic_imprinting0.79754633
107MP0003656_abnormal_erythrocyte_physiolo0.78865510
108MP0002160_abnormal_reproductive_system0.77661052
109MP0004036_abnormal_muscle_relaxation0.77220389
110MP0002233_abnormal_nose_morphology0.76988557
111MP0003698_abnormal_male_reproductive0.76451936
112MP0001286_abnormal_eye_development0.76285920
113MP0005085_abnormal_gallbladder_physiolo0.76240447
114MP0001485_abnormal_pinna_reflex0.76220777
115MP0005253_abnormal_eye_physiology0.76150846
116MP0000858_altered_metastatic_potential0.76127432
117MP0005174_abnormal_tail_pigmentation0.75937589
118MP0010307_abnormal_tumor_latency0.75642511
119MP0005025_abnormal_response_to0.75482736
120MP0001145_abnormal_male_reproductive0.74971437
121MP0005376_homeostasis/metabolism_phenot0.74440537
122MP0002086_abnormal_extraembryonic_tissu0.74438784
123MP0005671_abnormal_response_to0.73007081
124MP0004142_abnormal_muscle_tone0.72043398
125MP0002269_muscular_atrophy0.71377963
126MP0001919_abnormal_reproductive_system0.70902377
127MP0003191_abnormal_cellular_cholesterol0.70889945
128MP0003699_abnormal_female_reproductive0.70844550
129MP0009672_abnormal_birth_weight0.70772652
130MP0002420_abnormal_adaptive_immunity0.70719249
131MP0005385_cardiovascular_system_phenoty0.70580846
132MP0001544_abnormal_cardiovascular_syste0.70580846
133MP0009840_abnormal_foam_cell0.70296735
134MP0001819_abnormal_immune_cell0.69307622
135MP0002161_abnormal_fertility/fecundity0.68577657
136MP0005389_reproductive_system_phenotype0.68183179
137MP0000343_altered_response_to0.67405298
138MP0005551_abnormal_eye_electrophysiolog0.65993467
139MP0001929_abnormal_gametogenesis0.65501134
140MP0000653_abnormal_sex_gland0.64676514
141MP0000372_irregular_coat_pigmentation0.64455022
142MP0000598_abnormal_liver_morphology0.62535998
143MP0008469_abnormal_protein_level0.61991067
144MP0002085_abnormal_embryonic_tissue0.61279167
145MP0005360_urolithiasis0.60506806
146MP0005408_hypopigmentation0.59947947
147MP0005384_cellular_phenotype0.59224414
148MP0001293_anophthalmia0.58643592
149MP0002452_abnormal_antigen_presenting0.58607787

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.49805568
2Abnormal number of erythroid precursors (HP:0012131)4.49061602
3Hepatic necrosis (HP:0002605)4.33392035
4Hepatocellular necrosis (HP:0001404)4.21137745
5Birth length less than 3rd percentile (HP:0003561)3.96139304
6Mitochondrial inheritance (HP:0001427)3.91872373
7Acute necrotizing encephalopathy (HP:0006965)3.85162477
8Increased CSF lactate (HP:0002490)3.83630332
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.82587680
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.82587680
11Aplastic anemia (HP:0001915)3.77165366
12Abnormal mitochondria in muscle tissue (HP:0008316)3.71630376
13Abnormality of the labia minora (HP:0012880)3.56979835
14Abnormality of the anterior horn cell (HP:0006802)3.54147490
15Degeneration of anterior horn cells (HP:0002398)3.54147490
16* Increased serum lactate (HP:0002151)3.46927675
17Acute encephalopathy (HP:0006846)3.43392078
18Abnormality of glycolysis (HP:0004366)3.32650390
19Increased serum pyruvate (HP:0003542)3.32650390
20Oral leukoplakia (HP:0002745)3.24397733
21Reticulocytopenia (HP:0001896)3.21237998
22Lipid accumulation in hepatocytes (HP:0006561)3.19736259
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18094470
24Lactic acidosis (HP:0003128)3.13115163
25Increased hepatocellular lipid droplets (HP:0006565)3.10393443
26Thrombocytosis (HP:0001894)2.99028767
27Progressive macrocephaly (HP:0004481)2.96795682
28Exercise intolerance (HP:0003546)2.89242053
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84973636
30Multiple enchondromatosis (HP:0005701)2.81122479
31Nausea (HP:0002018)2.80388931
32Generalized aminoaciduria (HP:0002909)2.78268954
33Type I transferrin isoform profile (HP:0003642)2.77146245
34Increased intramyocellular lipid droplets (HP:0012240)2.76948459
35Breast hypoplasia (HP:0003187)2.76930314
36Rough bone trabeculation (HP:0100670)2.74571636
37Increased muscle lipid content (HP:0009058)2.72758786
38Abnormality of fatty-acid metabolism (HP:0004359)2.72139791
39Macrocytic anemia (HP:0001972)2.72120264
40Cerebral edema (HP:0002181)2.70063019
41Respiratory failure (HP:0002878)2.66656899
42Meckel diverticulum (HP:0002245)2.65009756
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61573730
44Abnormality of alanine metabolism (HP:0010916)2.61573730
45Hyperalaninemia (HP:0003348)2.61573730
46Abnormality of methionine metabolism (HP:0010901)2.60793420
47Septo-optic dysplasia (HP:0100842)2.56367567
48Abnormal lung lobation (HP:0002101)2.54288547
49Cerebral hypomyelination (HP:0006808)2.52717566
50Abnormality of the ileum (HP:0001549)2.51634720
51Exertional dyspnea (HP:0002875)2.51305779
52Pallor (HP:0000980)2.48088577
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46114560
54Supernumerary spleens (HP:0009799)2.44769983
55Respiratory difficulties (HP:0002880)2.40308953
56Rhabdomyolysis (HP:0003201)2.40243355
57Carpal bone hypoplasia (HP:0001498)2.39559825
58CNS demyelination (HP:0007305)2.38860871
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37235184
60Dicarboxylic aciduria (HP:0003215)2.34801227
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34801227
62Renal Fanconi syndrome (HP:0001994)2.34404917
63Reduced antithrombin III activity (HP:0001976)2.33713202
64Abnormality of chromosome stability (HP:0003220)2.32522692
65Microretrognathia (HP:0000308)2.29828620
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.25653572
67Colon cancer (HP:0003003)2.24806457
68Chromsome breakage (HP:0040012)2.24575688
69Poor head control (HP:0002421)2.23890218
70Hyperglycinuria (HP:0003108)2.22272403
71Methylmalonic acidemia (HP:0002912)2.20110621
72Lethargy (HP:0001254)2.18943817
73Premature graying of hair (HP:0002216)2.18516347
74Pancytopenia (HP:0001876)2.18420375
75Gonadotropin excess (HP:0000837)2.18255162
76Optic disc pallor (HP:0000543)2.16565382
77Horseshoe kidney (HP:0000085)2.12528312
78Megaloblastic anemia (HP:0001889)2.11562459
793-Methylglutaconic aciduria (HP:0003535)2.11098710
80Palpitations (HP:0001962)2.10617758
81Pendular nystagmus (HP:0012043)2.09564452
82Methylmalonic aciduria (HP:0012120)2.09267285
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07543516
84Abnormality of glycine metabolism (HP:0010895)2.06005669
85Abnormality of serine family amino acid metabolism (HP:0010894)2.06005669
86Type 2 muscle fiber atrophy (HP:0003554)2.04437005
87Ragged-red muscle fibers (HP:0003200)2.03229889
88Stenosis of the external auditory canal (HP:0000402)2.01871455
89Leukodystrophy (HP:0002415)2.00953044
90Cellular immunodeficiency (HP:0005374)2.00312828
91Muscle fiber atrophy (HP:0100295)2.00252886
92Self-mutilation (HP:0000742)1.99264979
93Gliosis (HP:0002171)1.99177992
94Agnosia (HP:0010524)1.99011638
95Abnormality of urine glucose concentration (HP:0011016)1.98758737
96Glycosuria (HP:0003076)1.98758737
97Progressive muscle weakness (HP:0003323)1.98733823
98Emotional lability (HP:0000712)1.98203166
99Bone marrow hypocellularity (HP:0005528)1.97396254
100Absent septum pellucidum (HP:0001331)1.96981828
101Rhabdomyosarcoma (HP:0002859)1.96598151
102Shoulder girdle muscle weakness (HP:0003547)1.96570968
103Hyperglycinemia (HP:0002154)1.96421413
104Sparse eyelashes (HP:0000653)1.95327767
105IgM deficiency (HP:0002850)1.95305206
106Abnormality of the preputium (HP:0100587)1.93617676
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92831756
108Abnormal protein N-linked glycosylation (HP:0012347)1.92831756
109Abnormal protein glycosylation (HP:0012346)1.92831756
110Abnormal glycosylation (HP:0012345)1.92831756
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92250055
112Absent thumb (HP:0009777)1.91499374
113Nephroblastoma (Wilms tumor) (HP:0002667)1.91248554
114Myelodysplasia (HP:0002863)1.90483240
115Abnormal trabecular bone morphology (HP:0100671)1.89842439
116Abnormality of serum amino acid levels (HP:0003112)1.88745665
117Cleft eyelid (HP:0000625)1.87223075
118Abnormality of the septum pellucidum (HP:0007375)1.87015428
119Abnormality of pyrimidine metabolism (HP:0004353)1.86515188
120Duodenal stenosis (HP:0100867)1.86382229
121Small intestinal stenosis (HP:0012848)1.86382229
122Bile duct proliferation (HP:0001408)1.85610237
123Abnormal biliary tract physiology (HP:0012439)1.85610237
124Proximal tubulopathy (HP:0000114)1.85413501
125Cortical dysplasia (HP:0002539)1.84531674
126Hypoplasia of the pons (HP:0012110)1.82670905
127Patellar aplasia (HP:0006443)1.82028786
128Renal cortical cysts (HP:0000803)1.81177807
129Unsteady gait (HP:0002317)1.79640347
130Abnormality of the duodenum (HP:0002246)1.78963115
131Tongue fasciculations (HP:0001308)1.77340595
132Triphalangeal thumb (HP:0001199)1.76589026
133Neoplasm of head and neck (HP:0012288)1.76102543
134Esophageal neoplasm (HP:0100751)1.76102543
135Sloping forehead (HP:0000340)1.75580451
136Embryonal renal neoplasm (HP:0011794)1.75469044
137Aplasia/Hypoplasia of the patella (HP:0006498)1.74999118
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.71791890
139Hypoplasia of the fovea (HP:0007750)1.71791890
140Hyperinsulinemic hypoglycemia (HP:0000825)1.71289426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71037182
2WEE13.97146844
3STK163.47869341
4VRK23.38993200
5PBK3.34447616
6EIF2AK13.23961248
7NME23.22375405
8TRIM282.82197341
9EIF2AK32.60228962
10CDC72.59345578
11BCKDK2.48936962
12TSSK62.46311530
13TAF12.45686226
14VRK12.35025631
15BRSK22.27539895
16NUAK12.26084505
17NEK12.16963174
18ACVR1B2.06234034
19MAP4K22.01623506
20SRPK11.96975684
21PLK41.85622721
22TNIK1.81003152
23WNK31.78732948
24CCNB11.62484126
25PLK11.56131400
26MYLK1.51674147
27NME11.46644330
28CDK81.45974857
29FLT31.43786952
30NEK21.40767551
31IRAK41.39897976
32BRSK11.36939796
33CDK191.33956292
34RPS6KB21.31472430
35TTK1.31217022
36PIM21.30993213
37BCR1.30708377
38AURKB1.29846547
39RPS6KA41.27751222
40ZAK1.27107707
41ATR1.26612148
42MAP2K31.23022229
43PLK31.22120070
44DYRK21.21827125
45MAP4K11.19695243
46MKNK11.18456253
47DYRK31.17174587
48TESK21.17110602
49PASK1.15322063
50CDK71.14502434
51CDK41.14133751
52PDK31.06366217
53PDK41.06366217
54TEC1.01383060
55TGFBR11.01259952
56PNCK1.01150090
57MAPKAPK30.99955829
58BMPR1B0.99592744
59AURKA0.99356056
60MKNK20.96622374
61KIT0.95978894
62TAOK20.95654977
63STK40.94380835
64STK38L0.93625655
65MAP3K30.91255903
66KDR0.91012308
67MAP3K120.90950622
68CSNK1G10.90408104
69CSNK1G30.89630451
70BRAF0.85841095
71MAP2K60.85476251
72MUSK0.84280206
73ZAP700.80301845
74MAP3K90.79645109
75EIF2AK20.79480531
76PAK40.77389599
77OBSCN0.77302500
78CSNK1G20.76669340
79BTK0.76483182
80TLK10.75994913
81CSNK2A10.75734732
82ERBB30.75569609
83DAPK10.74212997
84MST40.71050949
85MAP3K80.70873428
86GRK10.70777901
87CHEK20.70257341
88MARK30.68372611
89CSNK2A20.66955124
90MAP3K40.64492063
91MAP3K110.64145232
92STK240.62803399
93TXK0.62405590
94PIM10.60303296
95ERBB40.59963045
96CASK0.58682486
97ALK0.58495432
98INSRR0.58381707
99IRAK30.56695464
100ILK0.56512856
101FGR0.55740963
102CDK90.55623941
103ABL20.55457717
104CSNK1A1L0.54809129
105SIK30.53923024
106MAP2K70.53391560
107CHEK10.51576152
108PDK20.51418057
109PINK10.49957347
110STK390.48995262
111PLK20.48402254
112EPHA20.47200648
113GRK60.46763838
114CSNK1E0.45678699
115NEK90.45464391
116TESK10.44901146
117MAP3K50.44225465
118AKT30.43625349
119STK100.43580554
120OXSR10.43208130
121RPS6KA50.41755815
122ARAF0.40913121
123PKN20.39501445
124CLK10.39339508
125ATM0.39093422
126CDK20.37851660
127TYK20.37837830
128SYK0.36637954
129NLK0.36238528
130ADRBK20.33524063
131KSR10.33291715
132PAK10.32178624
133MATK0.30755605
134CDK30.30579491
135PRKCI0.29301092
136RPS6KB10.28769384
137CSF1R0.28153118
138CDK10.24728148
139STK30.23296236
140PRKCG0.22859709

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.17346674
2Proteasome_Homo sapiens_hsa030504.16979316
3Ribosome_Homo sapiens_hsa030103.59223455
4Mismatch repair_Homo sapiens_hsa034303.58380914
5RNA polymerase_Homo sapiens_hsa030203.52308105
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08066906
7Base excision repair_Homo sapiens_hsa034102.69262746
8Pyrimidine metabolism_Homo sapiens_hsa002402.63086089
9Homologous recombination_Homo sapiens_hsa034402.59069575
10Nucleotide excision repair_Homo sapiens_hsa034202.52627239
11Spliceosome_Homo sapiens_hsa030402.49540030
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35579989
13RNA transport_Homo sapiens_hsa030132.32102132
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12604870
15Parkinsons disease_Homo sapiens_hsa050122.12049086
16Oxidative phosphorylation_Homo sapiens_hsa001902.03311802
17One carbon pool by folate_Homo sapiens_hsa006701.94935687
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84312920
19Cell cycle_Homo sapiens_hsa041101.71642149
20Steroid biosynthesis_Homo sapiens_hsa001001.68918860
21RNA degradation_Homo sapiens_hsa030181.68589041
22Non-homologous end-joining_Homo sapiens_hsa034501.63634092
23Basal transcription factors_Homo sapiens_hsa030221.63421855
24Huntingtons disease_Homo sapiens_hsa050161.63300279
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62972585
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62336507
27Protein export_Homo sapiens_hsa030601.57057671
28Fanconi anemia pathway_Homo sapiens_hsa034601.54854875
29Purine metabolism_Homo sapiens_hsa002301.52016833
30Folate biosynthesis_Homo sapiens_hsa007901.45248226
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44351845
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.42687000
33Carbon metabolism_Homo sapiens_hsa012001.38482582
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38364960
35Pentose phosphate pathway_Homo sapiens_hsa000301.27644234
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25879886
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.23911883
38Biosynthesis of amino acids_Homo sapiens_hsa012301.22237939
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12971566
40Alzheimers disease_Homo sapiens_hsa050101.09392598
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09088433
42Vitamin B6 metabolism_Homo sapiens_hsa007501.05473265
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99610628
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99575753
45Propanoate metabolism_Homo sapiens_hsa006400.92386223
46Sulfur metabolism_Homo sapiens_hsa009200.89788310
47Epstein-Barr virus infection_Homo sapiens_hsa051690.89725984
48Glutathione metabolism_Homo sapiens_hsa004800.89599906
49p53 signaling pathway_Homo sapiens_hsa041150.87149775
50Sulfur relay system_Homo sapiens_hsa041220.86096207
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85944347
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82458352
53Fructose and mannose metabolism_Homo sapiens_hsa000510.82250257
54Butanoate metabolism_Homo sapiens_hsa006500.81213538
55Pyruvate metabolism_Homo sapiens_hsa006200.80674076
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.80477915
57Selenocompound metabolism_Homo sapiens_hsa004500.80252792
58mRNA surveillance pathway_Homo sapiens_hsa030150.78182082
59Galactose metabolism_Homo sapiens_hsa000520.73430635
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72764839
61Fatty acid degradation_Homo sapiens_hsa000710.72494921
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71446696
63Metabolic pathways_Homo sapiens_hsa011000.70401507
64Caffeine metabolism_Homo sapiens_hsa002320.67911097
65Peroxisome_Homo sapiens_hsa041460.65154806
66Herpes simplex infection_Homo sapiens_hsa051680.64508659
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61219341
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60723328
69Antigen processing and presentation_Homo sapiens_hsa046120.55705742
70Legionellosis_Homo sapiens_hsa051340.55336665
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55231871
72Regulation of autophagy_Homo sapiens_hsa041400.53152532
73Tryptophan metabolism_Homo sapiens_hsa003800.50085889
74Collecting duct acid secretion_Homo sapiens_hsa049660.46719118
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46272699
76N-Glycan biosynthesis_Homo sapiens_hsa005100.46204358
77Cardiac muscle contraction_Homo sapiens_hsa042600.45460382
78Fatty acid elongation_Homo sapiens_hsa000620.44736844
79beta-Alanine metabolism_Homo sapiens_hsa004100.44408775
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43257469
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42929488
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39360197
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37841231
84Thyroid cancer_Homo sapiens_hsa052160.35065169
85Fatty acid metabolism_Homo sapiens_hsa012120.33437600
86Primary immunodeficiency_Homo sapiens_hsa053400.32767936
87Oocyte meiosis_Homo sapiens_hsa041140.30997139
88Arginine and proline metabolism_Homo sapiens_hsa003300.29086662
89Starch and sucrose metabolism_Homo sapiens_hsa005000.28973529
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28716172
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28544423
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27984253
93Arachidonic acid metabolism_Homo sapiens_hsa005900.26635455
94Systemic lupus erythematosus_Homo sapiens_hsa053220.26557837
95Alcoholism_Homo sapiens_hsa050340.26539541
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25534687
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24958703
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24361213
99Phenylalanine metabolism_Homo sapiens_hsa003600.24186738
100Tyrosine metabolism_Homo sapiens_hsa003500.23326742
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.23200406
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21755945
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21572224
104Phototransduction_Homo sapiens_hsa047440.21121299
105Retinol metabolism_Homo sapiens_hsa008300.19773591
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.18943082
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17049953
108Vitamin digestion and absorption_Homo sapiens_hsa049770.16099817
109Viral carcinogenesis_Homo sapiens_hsa052030.14832597
110Renin-angiotensin system_Homo sapiens_hsa046140.14412874
111Fat digestion and absorption_Homo sapiens_hsa049750.14288630
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14041479
113Other glycan degradation_Homo sapiens_hsa005110.13319151
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12952192
115HTLV-I infection_Homo sapiens_hsa051660.12478461
116Chemical carcinogenesis_Homo sapiens_hsa052040.11384104
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10769886

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