MRPL45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)4.78578998
2ribosomal small subunit biogenesis (GO:0042274)4.61607995
3DNA replication checkpoint (GO:0000076)4.56059958
4polyketide metabolic process (GO:0030638)4.48500793
5doxorubicin metabolic process (GO:0044598)4.48500793
6daunorubicin metabolic process (GO:0044597)4.48500793
7maturation of SSU-rRNA (GO:0030490)4.47320068
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.29653721
9ribonucleoprotein complex biogenesis (GO:0022613)4.23039720
10rRNA methylation (GO:0031167)4.22625306
11cullin deneddylation (GO:0010388)4.20913896
12ribosome biogenesis (GO:0042254)4.19776375
13formation of translation preinitiation complex (GO:0001731)4.14428062
14proteasome assembly (GO:0043248)4.13679985
15ribosomal large subunit biogenesis (GO:0042273)4.12763096
16protein localization to kinetochore (GO:0034501)4.08146431
17pseudouridine synthesis (GO:0001522)4.06679943
18DNA replication initiation (GO:0006270)4.05883912
19DNA damage response, detection of DNA damage (GO:0042769)3.96849220
20ribosomal small subunit assembly (GO:0000028)3.93566075
21regulation of cellular amino acid metabolic process (GO:0006521)3.91867476
22chaperone-mediated protein transport (GO:0072321)3.88359084
23protein deneddylation (GO:0000338)3.83194522
24DNA replication-dependent nucleosome organization (GO:0034723)3.81972452
25DNA replication-dependent nucleosome assembly (GO:0006335)3.81972452
26transcription from RNA polymerase I promoter (GO:0006360)3.66866255
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65482336
28mitotic metaphase plate congression (GO:0007080)3.65443705
29positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.62902479
30rRNA processing (GO:0006364)3.60927090
31DNA strand elongation involved in DNA replication (GO:0006271)3.60291692
32non-recombinational repair (GO:0000726)3.60139054
33double-strand break repair via nonhomologous end joining (GO:0006303)3.60139054
34spliceosomal snRNP assembly (GO:0000387)3.58613056
35DNA deamination (GO:0045006)3.58141574
36telomere maintenance via semi-conservative replication (GO:0032201)3.57509324
37oxidative phosphorylation (GO:0006119)3.57230300
38cellular component biogenesis (GO:0044085)3.56590945
39CENP-A containing nucleosome assembly (GO:0034080)3.56150691
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.55195424
41termination of RNA polymerase III transcription (GO:0006386)3.55195424
42regulation of telomere maintenance via telomerase (GO:0032210)3.55144313
43chromatin remodeling at centromere (GO:0031055)3.54850134
44nucleobase biosynthetic process (GO:0046112)3.54055326
45DNA double-strand break processing (GO:0000729)3.52324668
46positive regulation of ligase activity (GO:0051351)3.51279151
47IMP metabolic process (GO:0046040)3.50751886
48establishment of viral latency (GO:0019043)3.49806902
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47747633
50viral transcription (GO:0019083)3.47139245
51rRNA metabolic process (GO:0016072)3.47055828
52mitotic sister chromatid segregation (GO:0000070)3.46778503
53DNA strand elongation (GO:0022616)3.46676817
54regulation of translation in response to stress (GO:0043555)3.43947577
55translational termination (GO:0006415)3.42614951
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37887659
57ATP synthesis coupled proton transport (GO:0015986)3.37887659
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34976337
59purine nucleobase biosynthetic process (GO:0009113)3.33734989
60regulation of ubiquitin-protein transferase activity (GO:0051438)3.30870052
61regulation of gene silencing by RNA (GO:0060966)3.29558204
62regulation of posttranscriptional gene silencing (GO:0060147)3.29558204
63regulation of gene silencing by miRNA (GO:0060964)3.29558204
64regulation of mitochondrial translation (GO:0070129)3.29349976
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28798899
66protein localization to chromosome, centromeric region (GO:0071459)3.28509064
67transcription from mitochondrial promoter (GO:0006390)3.26449986
68histone exchange (GO:0043486)3.26398611
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.25965868
70spliceosomal complex assembly (GO:0000245)3.25440877
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.23745704
72ribosome assembly (GO:0042255)3.22531471
73regulation of ligase activity (GO:0051340)3.22481634
74establishment of integrated proviral latency (GO:0075713)3.22196416
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20479708
76translation (GO:0006412)3.20320833
77termination of RNA polymerase I transcription (GO:0006363)3.19560596
787-methylguanosine mRNA capping (GO:0006370)3.19010320
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18204412
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18169338
81negative regulation of ligase activity (GO:0051352)3.18169338
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.15658178
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15331586
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15331586
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15331586
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15328554
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15328554
88RNA capping (GO:0036260)3.13975750
897-methylguanosine RNA capping (GO:0009452)3.13975750
90telomere maintenance via recombination (GO:0000722)3.13257046
91protein K6-linked ubiquitination (GO:0085020)3.12993133
92DNA ligation (GO:0006266)3.12787384
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12430958
94signal transduction involved in DNA damage checkpoint (GO:0072422)3.12430958
95tRNA aminoacylation for protein translation (GO:0006418)3.11133111
96transcription-coupled nucleotide-excision repair (GO:0006283)3.10505056
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09137089
98signal transduction involved in cell cycle checkpoint (GO:0072395)3.08443237
99negative regulation of telomere maintenance (GO:0032205)3.07978717
100telomere maintenance via telomere lengthening (GO:0010833)3.07588267
101DNA catabolic process, exonucleolytic (GO:0000738)3.07298666
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07064216
103amino acid activation (GO:0043038)3.06504918
104tRNA aminoacylation (GO:0043039)3.06504918
105translational initiation (GO:0006413)3.06484091
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05517640
107rRNA transcription (GO:0009303)3.04455984
108DNA replication-independent nucleosome organization (GO:0034724)3.03607038
109DNA replication-independent nucleosome assembly (GO:0006336)3.03607038
110IMP biosynthetic process (GO:0006188)3.03540489
111mitotic recombination (GO:0006312)3.02818902
112L-serine metabolic process (GO:0006563)3.02340632
113kinetochore assembly (GO:0051382)3.02175991
114respiratory chain complex IV assembly (GO:0008535)3.01191295
115negative regulation of telomerase activity (GO:0051974)3.01048954
116translational elongation (GO:0006414)2.99962956
117protein targeting to mitochondrion (GO:0006626)2.99874721
118metaphase plate congression (GO:0051310)2.99580203
119respiratory electron transport chain (GO:0022904)2.96976725
120G1/S transition of mitotic cell cycle (GO:0000082)2.96818414
121cell cycle G1/S phase transition (GO:0044843)2.96818414
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96796440
123inner mitochondrial membrane organization (GO:0007007)2.95498878
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94167285
125mitochondrial respiratory chain complex assembly (GO:0033108)2.94055303
126regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94040951
127cotranslational protein targeting to membrane (GO:0006613)2.93046824
128transcription initiation from RNA polymerase I promoter (GO:0006361)2.92860485
129pteridine-containing compound biosynthetic process (GO:0042559)2.92621463
130protein complex biogenesis (GO:0070271)2.92503802
131maturation of 5.8S rRNA (GO:0000460)2.92146944
132DNA unwinding involved in DNA replication (GO:0006268)2.91977693
133lactate metabolic process (GO:0006089)2.90783999
134regulation of mitotic spindle checkpoint (GO:1903504)2.90702788
135regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90702788
136kinetochore organization (GO:0051383)2.90626487
137nuclear pore organization (GO:0006999)2.89466640
138electron transport chain (GO:0022900)2.89415979
139regulation of helicase activity (GO:0051095)2.88472713
140mitochondrial RNA metabolic process (GO:0000959)2.87460805
141protein neddylation (GO:0045116)2.87400880
142attachment of spindle microtubules to kinetochore (GO:0008608)2.87104101
143folic acid-containing compound biosynthetic process (GO:0009396)2.86709889
144regulation of cellular amine metabolic process (GO:0033238)2.86545621
145protein targeting to ER (GO:0045047)2.86373024
146DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84941835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40222711
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19458630
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11785296
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76025749
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52327527
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35604733
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23893562
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.23103521
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.09655656
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.09655656
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.09655656
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07821488
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.05374473
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02419956
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98904107
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96178372
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95574940
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95445950
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94382962
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75026488
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63681978
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.43635368
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.36667705
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.35938097
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33974196
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17583418
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14507524
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13107006
29VDR_23849224_ChIP-Seq_CD4+_Human2.12259623
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11243477
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08969576
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08250774
33XRN2_22483619_ChIP-Seq_HELA_Human2.05832502
34FOXP3_21729870_ChIP-Seq_TREG_Human2.01641779
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00636242
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95615885
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95318449
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95182774
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93828215
40DCP1A_22483619_ChIP-Seq_HELA_Human1.92592516
41* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89595550
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84818355
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.82641748
44TTF2_22483619_ChIP-Seq_HELA_Human1.80512338
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80095019
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78012089
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.76706700
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.65091367
49ELK1_19687146_ChIP-ChIP_HELA_Human1.64193748
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.63888651
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60354990
52* GABP_19822575_ChIP-Seq_HepG2_Human1.58800953
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57771423
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55267448
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52806967
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52746918
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52489324
58IRF1_19129219_ChIP-ChIP_H3396_Human1.48642766
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45287282
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44798841
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44337775
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41572322
63* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40389184
64AR_21909140_ChIP-Seq_LNCAP_Human1.39700869
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38296747
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37009916
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36328638
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33994732
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31839710
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29912678
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24701750
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18505567
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17376246
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16386510
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.14790582
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.14746792
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.14483067
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14229432
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13543157
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.12551891
81MYC_18940864_ChIP-ChIP_HL60_Human1.12359742
82NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10828004
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10309614
84* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10062657
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09468382
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09372237
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07306951
88KDM5A_27292631_Chip-Seq_BREAST_Human1.06806723
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04455079
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03684779
91* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02604110
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01257815
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00595599
94ZNF263_19887448_ChIP-Seq_K562_Human0.99297533
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99290378
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98095411
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97304240
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.97252319
99CIITA_25753668_ChIP-Seq_RAJI_Human0.97218367
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90150892
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89689855
102POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89469191
103* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89421079
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89187972
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88363235
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88125398
107* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87785900
108ELF5_23300383_ChIP-Seq_T47D_Human0.87636690
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.87258902
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86828595
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86537593
112NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86508827
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86154383
114EWS_26573619_Chip-Seq_HEK293_Human0.83230302
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.81050310
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80242506
117TFEB_21752829_ChIP-Seq_HELA_Human0.78378099
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75996193
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74756956
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70443123
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70304989
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70154446
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.69918309
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68818279
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.68304975
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.66805814
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66779820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.36434987
2MP0003693_abnormal_embryo_hatching4.24842203
3MP0008057_abnormal_DNA_replication4.06317967
4MP0006292_abnormal_olfactory_placode3.75201257
5MP0010094_abnormal_chromosome_stability3.68437970
6MP0003111_abnormal_nucleus_morphology3.56002829
7MP0003077_abnormal_cell_cycle3.23169816
8MP0008058_abnormal_DNA_repair2.95604144
9MP0008932_abnormal_embryonic_tissue2.69460614
10MP0009697_abnormal_copulation2.61907032
11MP0003011_delayed_dark_adaptation2.51800962
12MP0003136_yellow_coat_color2.50579456
13MP0003806_abnormal_nucleotide_metabolis2.38428052
14MP0006035_abnormal_mitochondrial_morpho2.36455248
15MP0003890_abnormal_embryonic-extraembry2.25930362
16MP0003786_premature_aging2.18292765
17MP0004133_heterotaxia2.17508516
18MP0003123_paternal_imprinting2.16088502
19MP0003718_maternal_effect2.09966907
20MP0005075_abnormal_melanosome_morpholog2.01429970
21MP0003315_abnormal_perineum_morphology1.94336987
22MP0008007_abnormal_cellular_replicative1.88257229
23MP0010307_abnormal_tumor_latency1.85785172
24MP0002277_abnormal_respiratory_mucosa1.72838259
25MP0000350_abnormal_cell_proliferation1.72641638
26MP0003186_abnormal_redox_activity1.70288758
27MP0009379_abnormal_foot_pigmentation1.65336189
28MP0002332_abnormal_exercise_endurance1.62509052
29MP0005394_taste/olfaction_phenotype1.62357983
30MP0005499_abnormal_olfactory_system1.62357983
31MP0002653_abnormal_ependyma_morphology1.62261967
32MP0005380_embryogenesis_phenotype1.61274341
33MP0001672_abnormal_embryogenesis/_devel1.61274341
34MP0003121_genomic_imprinting1.59234186
35MP0006036_abnormal_mitochondrial_physio1.58914966
36MP0001730_embryonic_growth_arrest1.58897618
37MP0008875_abnormal_xenobiotic_pharmacok1.54896258
38MP0001293_anophthalmia1.51973928
39MP0005408_hypopigmentation1.46084332
40MP0003938_abnormal_ear_development1.43134710
41MP0010030_abnormal_orbit_morphology1.38814750
42MP0008995_early_reproductive_senescence1.38306810
43MP0008877_abnormal_DNA_methylation1.36782252
44MP0002127_abnormal_cardiovascular_syste1.33965215
45MP0003984_embryonic_growth_retardation1.33653441
46MP0002085_abnormal_embryonic_tissue1.31492442
47MP0002088_abnormal_embryonic_growth/wei1.31438376
48MP0002132_abnormal_respiratory_system1.28515031
49MP0005266_abnormal_metabolism1.27459731
50MP0003941_abnormal_skin_development1.26947814
51MP0004381_abnormal_hair_follicle1.25877267
52MP0001697_abnormal_embryo_size1.24240157
53MP0003950_abnormal_plasma_membrane1.23381802
54MP0009672_abnormal_birth_weight1.22150002
55MP0002282_abnormal_trachea_morphology1.22057961
56MP0000313_abnormal_cell_death1.21538207
57MP0003195_calcinosis1.20350208
58MP0004264_abnormal_extraembryonic_tissu1.16247894
59MP0000490_abnormal_crypts_of1.14596563
60MP0008789_abnormal_olfactory_epithelium1.14004380
61MP0000049_abnormal_middle_ear1.13116511
62MP0002254_reproductive_system_inflammat1.11201031
63MP0002080_prenatal_lethality1.10978290
64MP0006072_abnormal_retinal_apoptosis1.09392382
65MP0005257_abnormal_intraocular_pressure1.06046839
66MP0002233_abnormal_nose_morphology1.05240239
67MP0002210_abnormal_sex_determination1.05230203
68MP0002084_abnormal_developmental_patter1.03924463
69MP0002396_abnormal_hematopoietic_system1.03771101
70MP0000566_synostosis1.03614664
71MP0001529_abnormal_vocalization1.01802492
72MP0001764_abnormal_homeostasis1.01083302
73MP0004147_increased_porphyrin_level0.99838299
74MP0001881_abnormal_mammary_gland0.99533337
75MP0001145_abnormal_male_reproductive0.98792158
76MP0001346_abnormal_lacrimal_gland0.97650249
77MP0004142_abnormal_muscle_tone0.96345122
78MP0010352_gastrointestinal_tract_polyps0.96181127
79MP0000762_abnormal_tongue_morphology0.95603601
80MP0002086_abnormal_extraembryonic_tissu0.95348388
81MP0005084_abnormal_gallbladder_morpholo0.95060447
82MP0002751_abnormal_autonomic_nervous0.94644116
83MP0002102_abnormal_ear_morphology0.94369723
84MP0000750_abnormal_muscle_regeneration0.93664945
85MP0003937_abnormal_limbs/digits/tail_de0.92401533
86MP0001286_abnormal_eye_development0.92198219
87MP0000749_muscle_degeneration0.91621249
88MP0000358_abnormal_cell_content/0.90947044
89MP0005395_other_phenotype0.90593038
90MP0003119_abnormal_digestive_system0.90583068
91MP0001727_abnormal_embryo_implantation0.90090002
92MP0004197_abnormal_fetal_growth/weight/0.88362617
93MP0002697_abnormal_eye_size0.88134944
94MP0003567_abnormal_fetal_cardiomyocyte0.84719422
95MP0003221_abnormal_cardiomyocyte_apopto0.84159883
96MP0000647_abnormal_sebaceous_gland0.84140623
97MP0003137_abnormal_impulse_conducting0.83118055
98MP0002163_abnormal_gland_morphology0.81068797
99MP0002160_abnormal_reproductive_system0.80280617
100MP0003646_muscle_fatigue0.79874144
101MP0001666_abnormal_nutrient_absorption0.79599056
102MP0001188_hyperpigmentation0.78873731
103MP0005379_endocrine/exocrine_gland_phen0.78429504
104MP0005187_abnormal_penis_morphology0.78291647
105MP0000678_abnormal_parathyroid_gland0.77748037
106MP0005332_abnormal_amino_acid0.77576057
107MP0002090_abnormal_vision0.77253238
108MP0002019_abnormal_tumor_incidence0.76323761
109MP0001929_abnormal_gametogenesis0.75233153
110MP0001661_extended_life_span0.74911157
111MP0003122_maternal_imprinting0.73983616
112MP0001324_abnormal_eye_pigmentation0.73395256
113MP0001119_abnormal_female_reproductive0.71412493
114MP0000653_abnormal_sex_gland0.70800785
115MP0005636_abnormal_mineral_homeostasis0.70733849
116MP0002234_abnormal_pharynx_morphology0.70180503
117MP0002114_abnormal_axial_skeleton0.69892780
118MP0003942_abnormal_urinary_system0.69730612
119MP0005330_cardiomyopathy0.69670076
120MP0004782_abnormal_surfactant_physiolog0.69627278
121MP0000372_irregular_coat_pigmentation0.69462035
122MP0009333_abnormal_splenocyte_physiolog0.69181892
123MP0005389_reproductive_system_phenotype0.68740623
124MP0002111_abnormal_tail_morphology0.68664675
125MP0002092_abnormal_eye_morphology0.65686318
126MP0005220_abnormal_exocrine_pancreas0.65264601
127MP0002938_white_spotting0.65191227
128MP0005501_abnormal_skin_physiology0.65129801
129MP0009703_decreased_birth_body0.64633041
130MP0005391_vision/eye_phenotype0.63593174
131MP0005645_abnormal_hypothalamus_physiol0.63347023
132MP0000432_abnormal_head_morphology0.63166536
133MP0002269_muscular_atrophy0.62025887
134MP0003755_abnormal_palate_morphology0.61659855
135MP0001485_abnormal_pinna_reflex0.61609604

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77601376
2Chromsome breakage (HP:0040012)4.42012124
3Reticulocytopenia (HP:0001896)3.61452351
4Abnormality of glycolysis (HP:0004366)3.61188343
5Increased serum pyruvate (HP:0003542)3.61188343
6Birth length less than 3rd percentile (HP:0003561)3.50009462
7Breast hypoplasia (HP:0003187)3.45321472
8Bilateral microphthalmos (HP:0007633)3.38022806
9Multiple enchondromatosis (HP:0005701)3.28468318
103-Methylglutaconic aciduria (HP:0003535)3.28367225
11Meckel diverticulum (HP:0002245)3.18471754
12Acute necrotizing encephalopathy (HP:0006965)3.18141325
13Microvesicular hepatic steatosis (HP:0001414)3.12554890
14Cerebral edema (HP:0002181)3.06603882
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01888329
16Abnormality of the ileum (HP:0001549)3.00400616
17Supernumerary spleens (HP:0009799)2.97884633
18Cerebral hypomyelination (HP:0006808)2.95729274
19Abnormality of the preputium (HP:0100587)2.91305442
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90714571
21Increased CSF lactate (HP:0002490)2.88458809
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.88049369
23Mitochondrial inheritance (HP:0001427)2.87324667
24Absent radius (HP:0003974)2.87012674
25Reduced antithrombin III activity (HP:0001976)2.86806802
26Abnormality of methionine metabolism (HP:0010901)2.85108719
27Abnormality of cells of the erythroid lineage (HP:0012130)2.83784779
28Duplicated collecting system (HP:0000081)2.81266181
29Rectal fistula (HP:0100590)2.81239914
30Rectovaginal fistula (HP:0000143)2.81239914
31Abnormal mitochondria in muscle tissue (HP:0008316)2.79726301
32Abnormal lung lobation (HP:0002101)2.79439001
33Nephroblastoma (Wilms tumor) (HP:0002667)2.76526280
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76466736
35Increased serum lactate (HP:0002151)2.72142372
36Absent forearm bone (HP:0003953)2.70934287
37Aplasia involving forearm bones (HP:0009822)2.70934287
38Impulsivity (HP:0100710)2.68148128
39Rough bone trabeculation (HP:0100670)2.66469158
40Increased intramyocellular lipid droplets (HP:0012240)2.65625287
41Hepatocellular necrosis (HP:0001404)2.64854535
42Lactic acidosis (HP:0003128)2.63679812
43Aplastic anemia (HP:0001915)2.58525916
44Hyperglycinemia (HP:0002154)2.58138286
45Rib fusion (HP:0000902)2.58002167
46Oral leukoplakia (HP:0002745)2.56834233
47Embryonal renal neoplasm (HP:0011794)2.56247931
48Abnormal number of erythroid precursors (HP:0012131)2.55649273
49Ependymoma (HP:0002888)2.53924314
50Progressive external ophthalmoplegia (HP:0000590)2.51341158
51Abnormality of the labia minora (HP:0012880)2.50413750
52Triphalangeal thumb (HP:0001199)2.49778035
53Duplication of thumb phalanx (HP:0009942)2.49360538
54Trismus (HP:0000211)2.48678833
55Rhabdomyosarcoma (HP:0002859)2.47425722
56Carpal bone hypoplasia (HP:0001498)2.46867518
57Abnormality of the anterior horn cell (HP:0006802)2.45364117
58Degeneration of anterior horn cells (HP:0002398)2.45364117
59Acute encephalopathy (HP:0006846)2.43590390
60Abnormality of chromosome stability (HP:0003220)2.40241601
61Progressive macrocephaly (HP:0004481)2.38679406
62Partial duplication of thumb phalanx (HP:0009944)2.36676589
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36061169
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36061169
65Duodenal stenosis (HP:0100867)2.35744547
66Small intestinal stenosis (HP:0012848)2.35744547
67Abnormality of the renal collecting system (HP:0004742)2.35218588
68Testicular atrophy (HP:0000029)2.34986866
69Increased hepatocellular lipid droplets (HP:0006565)2.32147640
70Patellar aplasia (HP:0006443)2.31828808
71Premature ovarian failure (HP:0008209)2.31800937
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31152233
73Pallor (HP:0000980)2.30370643
74Absent thumb (HP:0009777)2.30284352
75Hepatic necrosis (HP:0002605)2.30138140
76Bone marrow hypocellularity (HP:0005528)2.29442723
77Macrocytic anemia (HP:0001972)2.28556325
78Aplasia/hypoplasia of the humerus (HP:0006507)2.27405232
79Respiratory difficulties (HP:0002880)2.26010836
80Methylmalonic acidemia (HP:0002912)2.24803627
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24701229
82Abnormal protein N-linked glycosylation (HP:0012347)2.24701229
83Abnormal protein glycosylation (HP:0012346)2.24701229
84Abnormal glycosylation (HP:0012345)2.24701229
85Respiratory failure (HP:0002878)2.24244367
86Exercise intolerance (HP:0003546)2.24011537
87Type I transferrin isoform profile (HP:0003642)2.23897290
88Vaginal fistula (HP:0004320)2.21222647
89Horseshoe kidney (HP:0000085)2.20504730
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20093312
91Facial cleft (HP:0002006)2.18083416
92Neoplasm of the adrenal gland (HP:0100631)2.17514493
93Secondary amenorrhea (HP:0000869)2.17119653
94Intestinal fistula (HP:0100819)2.16485068
95Abnormality of serum amino acid levels (HP:0003112)2.16270397
96Colon cancer (HP:0003003)2.15895357
97Fused cervical vertebrae (HP:0002949)2.14406993
98Microretrognathia (HP:0000308)2.13955496
99Aplasia/Hypoplasia of the patella (HP:0006498)2.13745085
100Cleft eyelid (HP:0000625)2.13091995
101Increased muscle lipid content (HP:0009058)2.12941658
102Ragged-red muscle fibers (HP:0003200)2.08875710
103Renal Fanconi syndrome (HP:0001994)2.08569751
104Medulloblastoma (HP:0002885)2.08241028
105Sloping forehead (HP:0000340)2.08215634
106Abnormal trabecular bone morphology (HP:0100671)2.07238208
107Abnormality of glycine metabolism (HP:0010895)2.05131027
108Abnormality of serine family amino acid metabolism (HP:0010894)2.05131027
109Aplasia/Hypoplasia of the fovea (HP:0008060)2.03524705
110Hypoplasia of the fovea (HP:0007750)2.03524705
111Sparse eyelashes (HP:0000653)2.02152825
112Lipid accumulation in hepatocytes (HP:0006561)2.01606264
113Leukodystrophy (HP:0002415)2.01193388
114Lethargy (HP:0001254)1.99906965
115Exertional dyspnea (HP:0002875)1.98809314
116Gout (HP:0001997)1.98378945
117Tongue fasciculations (HP:0001308)1.98256130
118Partial duplication of the phalanx of hand (HP:0009999)1.97452548
119Tracheoesophageal fistula (HP:0002575)1.96375844
120Asplenia (HP:0001746)1.95780508
121Abnormality of the duodenum (HP:0002246)1.95374282
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.95240977
123Hypoglycemic coma (HP:0001325)1.94835578
124Pancreatic islet-cell hyperplasia (HP:0004510)1.94621667
125Posterior subcapsular cataract (HP:0007787)1.93305542
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.93047671
127Abdominal situs inversus (HP:0003363)1.92643887
128Abnormality of abdominal situs (HP:0011620)1.92643887
129Anomalous pulmonary venous return (HP:0010772)1.91412909
130Hypochromic microcytic anemia (HP:0004840)1.91407080
131Hyperinsulinemic hypoglycemia (HP:0000825)1.90882171
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90849181
133CNS demyelination (HP:0007305)1.87202890
134Glioma (HP:0009733)1.84419886
135Hyperglycinuria (HP:0003108)1.82622120
136Methylmalonic aciduria (HP:0012120)1.80523885
137Megaloblastic anemia (HP:0001889)1.78998364
138Hyperphosphaturia (HP:0003109)1.78229192
139Glycosuria (HP:0003076)1.77607282
140Abnormality of urine glucose concentration (HP:0011016)1.77607282
141Prolonged partial thromboplastin time (HP:0003645)1.75140473
142Myelodysplasia (HP:0002863)1.73887429
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.71215656
144Cholecystitis (HP:0001082)1.70572742
145Abnormal gallbladder physiology (HP:0012438)1.70572742
146Adrenal hypoplasia (HP:0000835)1.70422172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.50264122
2VRK23.97607992
3CDK123.46151216
4WEE13.36577397
5EIF2AK13.15588411
6STK163.13896313
7TTK3.00896926
8SRPK12.66679703
9TRIM282.33491073
10CDC72.29213819
11NME22.18937661
12TLK12.16075151
13EPHA22.12916327
14ADRBK22.05894081
15PLK42.05645607
16PBK2.05407332
17GRK52.00483130
18PLK11.98295398
19NUAK11.91957997
20GRK11.88821990
21VRK11.87454697
22CDK71.78245057
23TAF11.75065934
24TESK21.72074933
25STK241.71212787
26EIF2AK31.67844135
27GRK61.59937569
28GRK71.57469959
29NEK11.55682952
30TSSK61.48969501
31CHEK21.48900406
32AKT31.47350893
33ACVR1B1.46847383
34EIF2AK21.46444552
35NME11.45393061
36ZAK1.42172358
37AURKA1.38625068
38MKNK11.32140303
39AURKB1.29966146
40DYRK31.28437375
41MKNK21.27105165
42BRSK21.26388851
43STK38L1.14977206
44MST41.14760276
45PLK31.14066875
46DYRK21.11802110
47RPS6KB21.07346599
48BMPR1B1.06579937
49STK101.03972069
50PNCK1.03305979
51MAP3K121.00925714
52ATR1.00654947
53CHEK10.97426212
54NEK20.93693992
55TNIK0.93347160
56ERBB30.89534167
57BRAF0.88968890
58CDK80.86202810
59PDK20.84844903
60PDK40.83033039
61PDK30.83033039
62OBSCN0.82836786
63CSF1R0.82321867
64CASK0.81636314
65PRPF4B0.80608721
66PRKCI0.80063773
67MST1R0.79814662
68STK40.79507182
69PAK40.77607087
70SCYL20.76588603
71CSNK1G10.73994045
72SMG10.72076887
73CSNK2A10.70838216
74FGFR10.69608636
75ILK0.69235412
76PLK20.69224262
77DAPK10.67611855
78CSNK2A20.66284771
79WNK30.65419413
80MOS0.65348692
81MAPK70.65165505
82STK390.64992875
83PIM20.64970688
84CSNK1G30.64114747
85CDK40.63673878
86BRSK10.62880481
87ATM0.62734142
88CDK20.61044656
89PAK10.60457920
90STK30.60189260
91IRAK30.58421619
92MAP3K80.56546873
93AKT20.55334772
94BLK0.55232901
95ADRBK10.54647894
96MAPKAPK50.54590578
97BCKDK0.52312701
98CSNK1A1L0.51047071
99RPS6KA40.50993085
100CCNB10.48691495
101RPS6KA50.47994378
102CDK10.47391319
103INSRR0.47318209
104CSNK1E0.47078890
105ABL20.45106506
106YES10.44407086
107BCR0.43601487
108FLT30.43403753
109MET0.43373978
110ALK0.43318570
111LRRK20.43264562
112OXSR10.42818214
113MATK0.41929611
114MAP2K60.40502599
115MAP4K20.40284413
116IRAK40.39859875
117PHKG20.39316980
118PHKG10.39316980
119CSNK1G20.37496579
120MELK0.35157590
121PASK0.34985832
122CDK190.34984995
123WNK10.33978254
124LIMK10.33239230
125IKBKB0.32216328
126PIM10.31796860
127MYLK0.30532443
128WNK40.30412919
129TAOK20.29176660
130LATS10.28211233
131ARAF0.26707161
132SIK30.25168538
133CAMK40.24455266
134CDK30.23866662
135PRKCD0.23237920
136PRKDC0.21999879
137FER0.21479751
138MINK10.20436286
139ERBB40.18744125
140NEK60.18280625
141KDR0.16340719

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.30381520
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.03576771
3Proteasome_Homo sapiens_hsa030503.99041792
4RNA polymerase_Homo sapiens_hsa030203.80626610
5DNA replication_Homo sapiens_hsa030303.74095686
6Mismatch repair_Homo sapiens_hsa034303.45218406
7Homologous recombination_Homo sapiens_hsa034402.86783660
8Spliceosome_Homo sapiens_hsa030402.73019428
9RNA transport_Homo sapiens_hsa030132.64676447
10Oxidative phosphorylation_Homo sapiens_hsa001902.60200929
11Pyrimidine metabolism_Homo sapiens_hsa002402.49087152
12Nucleotide excision repair_Homo sapiens_hsa034202.45836822
13Fanconi anemia pathway_Homo sapiens_hsa034602.39670103
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36031590
15Vitamin B6 metabolism_Homo sapiens_hsa007502.34007055
16Parkinsons disease_Homo sapiens_hsa050122.31263573
17Base excision repair_Homo sapiens_hsa034102.17072313
18Basal transcription factors_Homo sapiens_hsa030222.15346551
19One carbon pool by folate_Homo sapiens_hsa006702.15063343
20Huntingtons disease_Homo sapiens_hsa050161.99190312
21Cell cycle_Homo sapiens_hsa041101.84202835
22RNA degradation_Homo sapiens_hsa030181.75293274
23Non-homologous end-joining_Homo sapiens_hsa034501.75148916
24Propanoate metabolism_Homo sapiens_hsa006401.65962554
25Caffeine metabolism_Homo sapiens_hsa002321.65461125
26Purine metabolism_Homo sapiens_hsa002301.40699362
27Alzheimers disease_Homo sapiens_hsa050101.40394335
28Arachidonic acid metabolism_Homo sapiens_hsa005901.30301342
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28018280
30mRNA surveillance pathway_Homo sapiens_hsa030151.26230750
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24967563
32Fructose and mannose metabolism_Homo sapiens_hsa000511.18031179
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14337974
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11108356
35p53 signaling pathway_Homo sapiens_hsa041151.03450447
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00629659
37Cardiac muscle contraction_Homo sapiens_hsa042600.96658675
38Linoleic acid metabolism_Homo sapiens_hsa005910.87411003
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85992107
40Folate biosynthesis_Homo sapiens_hsa007900.85582827
41Glutathione metabolism_Homo sapiens_hsa004800.85579576
42N-Glycan biosynthesis_Homo sapiens_hsa005100.81755975
43Fatty acid metabolism_Homo sapiens_hsa012120.80694608
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.80394647
45Epstein-Barr virus infection_Homo sapiens_hsa051690.79840195
46Sulfur metabolism_Homo sapiens_hsa009200.79420765
47Fatty acid degradation_Homo sapiens_hsa000710.78794919
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76892075
49Peroxisome_Homo sapiens_hsa041460.76749745
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76247209
51Carbon metabolism_Homo sapiens_hsa012000.74396176
52Protein export_Homo sapiens_hsa030600.74369960
53Pentose phosphate pathway_Homo sapiens_hsa000300.73105651
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72553273
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72318589
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71270178
57Biosynthesis of amino acids_Homo sapiens_hsa012300.68174675
58Metabolic pathways_Homo sapiens_hsa011000.66286743
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65602587
60Butanoate metabolism_Homo sapiens_hsa006500.64709005
61Galactose metabolism_Homo sapiens_hsa000520.64320729
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63660860
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61797461
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60950740
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.59469345
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56604448
67Tryptophan metabolism_Homo sapiens_hsa003800.56422664
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54678444
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54630922
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54004949
71Systemic lupus erythematosus_Homo sapiens_hsa053220.53842639
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53398298
73Sulfur relay system_Homo sapiens_hsa041220.53015968
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.50810271
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50285641
76Herpes simplex infection_Homo sapiens_hsa051680.48965388
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46850926
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.46168251
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44774758
80Ether lipid metabolism_Homo sapiens_hsa005650.44319131
81beta-Alanine metabolism_Homo sapiens_hsa004100.42458725
82Fat digestion and absorption_Homo sapiens_hsa049750.41922100
83Regulation of autophagy_Homo sapiens_hsa041400.40985676
84Arginine and proline metabolism_Homo sapiens_hsa003300.39817521
85Oocyte meiosis_Homo sapiens_hsa041140.37981833
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36848113
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36072031
88Fatty acid elongation_Homo sapiens_hsa000620.34029855
89Starch and sucrose metabolism_Homo sapiens_hsa005000.29213925
90Retinol metabolism_Homo sapiens_hsa008300.28002275
91Viral carcinogenesis_Homo sapiens_hsa052030.27499772
92Graft-versus-host disease_Homo sapiens_hsa053320.26800397
93Basal cell carcinoma_Homo sapiens_hsa052170.26708583
94Vitamin digestion and absorption_Homo sapiens_hsa049770.26509579
95Selenocompound metabolism_Homo sapiens_hsa004500.26326598
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.25998338
97Autoimmune thyroid disease_Homo sapiens_hsa053200.25705514
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25675330
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.25288034
100Asthma_Homo sapiens_hsa053100.21769130
101Arginine biosynthesis_Homo sapiens_hsa002200.21704191
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21011837
103Other glycan degradation_Homo sapiens_hsa005110.20717121
104Tyrosine metabolism_Homo sapiens_hsa003500.20380612
105Pyruvate metabolism_Homo sapiens_hsa006200.19407818
106Lysine degradation_Homo sapiens_hsa003100.19307392
107Allograft rejection_Homo sapiens_hsa053300.19125244
108Hedgehog signaling pathway_Homo sapiens_hsa043400.16867759
109Chemical carcinogenesis_Homo sapiens_hsa052040.16675887
110HTLV-I infection_Homo sapiens_hsa051660.15960225
111Phenylalanine metabolism_Homo sapiens_hsa003600.15474645
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15317365
113Thyroid cancer_Homo sapiens_hsa052160.15060064
114Sphingolipid metabolism_Homo sapiens_hsa006000.14982460
115Vibrio cholerae infection_Homo sapiens_hsa051100.12677304
116Steroid biosynthesis_Homo sapiens_hsa001000.12181074
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11401938
118TGF-beta signaling pathway_Homo sapiens_hsa043500.10730237
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10683213
120Legionellosis_Homo sapiens_hsa051340.10503538
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10434807
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10275028
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09182851
124Primary immunodeficiency_Homo sapiens_hsa053400.08033804
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.07694328
126Antigen processing and presentation_Homo sapiens_hsa046120.07624086
127Hippo signaling pathway_Homo sapiens_hsa043900.06481889
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.06141322
129Tight junction_Homo sapiens_hsa045300.06072044

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