MRPL46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.90150254
2rRNA modification (GO:0000154)5.62357022
3regulation of nuclear cell cycle DNA replication (GO:0033262)5.62079974
4maintenance of protein location in nucleus (GO:0051457)5.61145936
5rRNA methylation (GO:0031167)5.58643148
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.56105838
7protein localization to kinetochore (GO:0034501)5.55039330
8cullin deneddylation (GO:0010388)5.33861037
9somite rostral/caudal axis specification (GO:0032525)5.33770907
10negative regulation of epidermis development (GO:0045683)5.33469829
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.32826166
12cytidine deamination (GO:0009972)5.31641038
13cytidine metabolic process (GO:0046087)5.31641038
14cytidine catabolic process (GO:0006216)5.31641038
15regulation of mammary gland epithelial cell proliferation (GO:0033599)5.21858901
16rRNA transcription (GO:0009303)5.07884664
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.03292937
18chaperone-mediated protein transport (GO:0072321)5.02374411
19negative regulation of telomerase activity (GO:0051974)5.00199970
20proteasome assembly (GO:0043248)4.99990873
21regulation of telomere maintenance via telomerase (GO:0032210)4.99698365
22protein deneddylation (GO:0000338)4.87926330
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.85036060
24DNA replication checkpoint (GO:0000076)4.81856490
25regulation of response to osmotic stress (GO:0047484)4.80694680
26mitotic sister chromatid segregation (GO:0000070)4.77912294
27regulation of cilium movement (GO:0003352)4.74327276
28quinone metabolic process (GO:1901661)4.74009408
29regulation of MHC class I biosynthetic process (GO:0045343)4.65257510
30respiratory electron transport chain (GO:0022904)4.58443772
31phenol-containing compound catabolic process (GO:0019336)4.51339847
32regulation of translation in response to stress (GO:0043555)4.49116660
33electron transport chain (GO:0022900)4.48287890
34regulation of mitochondrial translation (GO:0070129)4.46602496
35negative regulation of epidermal cell differentiation (GO:0045605)4.45594699
36negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.38572977
37protein complex biogenesis (GO:0070271)4.37906594
38DNA damage response, detection of DNA damage (GO:0042769)4.30384238
39DNA replication-dependent nucleosome assembly (GO:0006335)4.28289914
40DNA replication-dependent nucleosome organization (GO:0034723)4.28289914
41mitochondrial respiratory chain complex assembly (GO:0033108)4.27817413
42GDP-mannose metabolic process (GO:0019673)4.24010586
43muscle organ morphogenesis (GO:0048644)4.23410623
44histone H4-K8 acetylation (GO:0043982)4.22876377
45histone H4-K5 acetylation (GO:0043981)4.22876377
46negative regulation of telomere maintenance (GO:0032205)4.22602276
47ribosomal small subunit biogenesis (GO:0042274)4.19981704
48histone H4-K12 acetylation (GO:0043983)4.18990857
49protein localization to chromosome, centromeric region (GO:0071459)4.18472438
50ribosome biogenesis (GO:0042254)4.08896011
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07439691
52formation of translation preinitiation complex (GO:0001731)4.06927425
53protein targeting to mitochondrion (GO:0006626)4.04363282
54pseudouridine synthesis (GO:0001522)4.04296115
55positive regulation of DNA-dependent DNA replication (GO:2000105)3.87435736
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82156564
57nucleoside transmembrane transport (GO:1901642)3.81830158
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.81193856
59termination of RNA polymerase III transcription (GO:0006386)3.80240978
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.80240978
61respiratory chain complex IV assembly (GO:0008535)3.78545463
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77811907
63ribosome assembly (GO:0042255)3.77228390
64coenzyme catabolic process (GO:0009109)3.77115300
65protein localization to mitochondrion (GO:0070585)3.77084795
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75918191
67establishment of protein localization to mitochondrion (GO:0072655)3.73910257
68notochord development (GO:0030903)3.72253118
69sister chromatid segregation (GO:0000819)3.71171009
70maturation of SSU-rRNA (GO:0030490)3.68426126
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67744768
72negative regulation of ligase activity (GO:0051352)3.67744768
73oxidative phosphorylation (GO:0006119)3.65390284
74ribonucleoprotein complex biogenesis (GO:0022613)3.64502125
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62225742
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62225742
77heterochromatin organization (GO:0070828)3.61061327
78chromatin remodeling at centromere (GO:0031055)3.60425783
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58370859
80DNA double-strand break processing (GO:0000729)3.57788352
81regulation of cellular amino acid metabolic process (GO:0006521)3.57560173
82protein neddylation (GO:0045116)3.56647175
83transcription from mitochondrial promoter (GO:0006390)3.55558223
84CENP-A containing nucleosome assembly (GO:0034080)3.51737773
85regulation of telomerase activity (GO:0051972)3.48164647
86cytochrome complex assembly (GO:0017004)3.46570521
87interferon-gamma production (GO:0032609)3.44903278
88peptidyl-histidine modification (GO:0018202)3.44846224
89pyrimidine ribonucleoside catabolic process (GO:0046133)3.44397485
90response to dietary excess (GO:0002021)3.43725496
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42098859
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40961057
93ribosomal small subunit assembly (GO:0000028)3.39704905
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.37259963
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37107101
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37107101
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37107101
98spliceosomal snRNP assembly (GO:0000387)3.36540964
99regulation of apoptotic process involved in morphogenesis (GO:1902337)3.34707526
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33874365
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33874365
102primitive streak formation (GO:0090009)3.28258292
103cellular component biogenesis (GO:0044085)3.27890766
104cardiovascular system development (GO:0072358)3.26243558
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26007437
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.26007437
107hormone catabolic process (GO:0042447)3.23640529
108translation (GO:0006412)3.23057703
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.22256238
110chromatin assembly (GO:0031497)3.21548328
111intestinal epithelial cell development (GO:0060576)3.20987527
112positive regulation of ligase activity (GO:0051351)3.19976676
113ubiquinone biosynthetic process (GO:0006744)3.16885842
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16507579
115ATP synthesis coupled proton transport (GO:0015986)3.16507579
116cell fate commitment involved in formation of primary germ layer (GO:0060795)3.14865043
117DNA catabolic process, exonucleolytic (GO:0000738)3.14332081
118maturation of 5.8S rRNA (GO:0000460)3.13478468
119mitochondrial RNA metabolic process (GO:0000959)3.13081764
120protein polyglutamylation (GO:0018095)3.11844679
121mitochondrial transport (GO:0006839)3.09555193
122rRNA metabolic process (GO:0016072)3.09438311
123DNA strand elongation involved in DNA replication (GO:0006271)3.07023303
124inner mitochondrial membrane organization (GO:0007007)3.06800129
125ribosomal large subunit biogenesis (GO:0042273)3.05436273
126purine nucleobase biosynthetic process (GO:0009113)3.05419289
127IMP biosynthetic process (GO:0006188)3.04850554
128apoptotic DNA fragmentation (GO:0006309)3.04474118
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03650965
130telomere maintenance via semi-conservative replication (GO:0032201)3.03221970
131regulation of ubiquitin-protein transferase activity (GO:0051438)3.00030896
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99578515
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98568767
134regulation of mitotic spindle checkpoint (GO:1903504)2.98568767
135tRNA processing (GO:0008033)2.97034755
136histone exchange (GO:0043486)2.96288785
137replication fork processing (GO:0031297)2.95066115
138DNA replication initiation (GO:0006270)2.95048550
139establishment of integrated proviral latency (GO:0075713)2.94624255
140negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.94398512
141aerobic respiration (GO:0009060)2.94011867
142DNA strand elongation (GO:0022616)2.93843033
143branching involved in mammary gland duct morphogenesis (GO:0060444)2.93427671
144mitochondrial DNA replication (GO:0006264)2.92852820
145microtubule severing (GO:0051013)2.92120403
146ubiquinone metabolic process (GO:0006743)2.91994955
147ATP biosynthetic process (GO:0006754)2.91294109
148purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91189426
149intracellular protein transmembrane import (GO:0044743)2.90720238
150purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89941946
151regulation of microtubule-based movement (GO:0060632)2.89392779
152nucleobase biosynthetic process (GO:0046112)2.88616488
153regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.87567530
154regulation of ligase activity (GO:0051340)2.87071702
155histone H4-K16 acetylation (GO:0043984)2.86128172
156GTP biosynthetic process (GO:0006183)2.85660097
157transcription from RNA polymerase I promoter (GO:0006360)2.85033382
158maintenance of protein localization in organelle (GO:0072595)2.84766863
159tRNA metabolic process (GO:0006399)2.83941774
160regulation of telomere maintenance (GO:0032204)2.83088308
161negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.82108218
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.82098156
163NADH dehydrogenase complex assembly (GO:0010257)2.82098156
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82098156
165intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.81811556
166mitochondrion distribution (GO:0048311)2.81284141
167cofactor transport (GO:0051181)2.80708612
168nuclear pore complex assembly (GO:0051292)2.80474638
169pteridine-containing compound biosynthetic process (GO:0042559)2.78252509
170nucleoside transport (GO:0015858)2.75210356
171mitotic G2/M transition checkpoint (GO:0044818)2.73578267
172mitotic chromosome condensation (GO:0007076)2.72496759
173nuclear pore organization (GO:0006999)2.67949207
174rRNA processing (GO:0006364)2.64967088
175DNA duplex unwinding (GO:0032508)2.62074068
176DNA unwinding involved in DNA replication (GO:0006268)2.62037532
177cellular modified amino acid catabolic process (GO:0042219)2.61541720
178regulation of G0 to G1 transition (GO:0070316)2.60129248
179daunorubicin metabolic process (GO:0044597)10.4774529
180polyketide metabolic process (GO:0030638)10.4774529
181doxorubicin metabolic process (GO:0044598)10.4774529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.50748983
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.22659758
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.96720289
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.96720289
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.96720289
6E2F7_22180533_ChIP-Seq_HELA_Human4.37350854
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21107599
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.09545577
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88593993
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.74902969
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63727598
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.60034940
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58746015
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.53359957
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51779188
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49304903
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.48814302
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.48587193
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45246481
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39787090
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38916369
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35535585
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33804175
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28294496
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.27872598
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.27243782
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.21507602
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.13524884
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02767393
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.01462082
31IRF1_19129219_ChIP-ChIP_H3396_Human2.00151554
32NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.97113989
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96467848
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93543779
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92905509
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91534553
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.90347009
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89349273
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86220101
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83193062
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81287966
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78870913
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76302661
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75770065
45MYC_18940864_ChIP-ChIP_HL60_Human1.72057496
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69687831
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67139701
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66950575
49* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66789060
50* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64763098
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59296298
52* FOXP3_21729870_ChIP-Seq_TREG_Human1.58703349
53XRN2_22483619_ChIP-Seq_HELA_Human1.53680409
54VDR_23849224_ChIP-Seq_CD4+_Human1.52925706
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52910799
56* E2F1_21310950_ChIP-Seq_MCF-7_Human1.43820156
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39715399
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39051172
59OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37631292
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37500476
61GABP_19822575_ChIP-Seq_HepG2_Human1.37148931
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35561159
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34525580
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32670310
65POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32351813
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31034064
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30304267
68DCP1A_22483619_ChIP-Seq_HELA_Human1.29578298
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29013126
70ZNF274_21170338_ChIP-Seq_K562_Hela1.28230734
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27287788
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25934153
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.24853180
74* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24163161
75E2F1_17053090_ChIP-ChIP_MCF-7_Human1.23831499
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23094253
77* TTF2_22483619_ChIP-Seq_HELA_Human1.22724138
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22022322
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.20504458
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19250888
81EWS_26573619_Chip-Seq_HEK293_Human1.18635522
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14158234
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13897557
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.13748308
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13574744
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13300359
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09976525
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07980769
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07850980
90* CIITA_25753668_ChIP-Seq_RAJI_Human1.07413225
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07258642
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.05328772
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04431455
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03918570
95KDM5A_27292631_Chip-Seq_BREAST_Human1.03638208
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03297302
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02533031
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02274199
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02183309
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01905984
101ELK1_19687146_ChIP-ChIP_HELA_Human1.01104219
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99293726
103IGF1R_20145208_ChIP-Seq_DFB_Human0.98157880
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96832103
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96682216
106VDR_22108803_ChIP-Seq_LS180_Human0.96566338
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95311606
108AR_21909140_ChIP-Seq_LNCAP_Human0.94335180
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93065138
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.92168491
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91741705
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91658279
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90576537
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88339420
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88236793
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88159933
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87980980
118FUS_26573619_Chip-Seq_HEK293_Human0.87792471
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87569304
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86924022
121* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86473698
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.86310126
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.85850500
124TP53_22573176_ChIP-Seq_HFKS_Human0.85575983
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84092826
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.81383129
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.78423924
128* YY1_22570637_ChIP-Seq_MALME-3M_Human0.76953537
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73995189
130TFEB_21752829_ChIP-Seq_HELA_Human0.72894133
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71441478
132HTT_18923047_ChIP-ChIP_STHdh_Human0.71093132
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70952763
134ELF5_23300383_ChIP-Seq_T47D_Human0.68057691
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66917910
136FOXP1_21924763_ChIP-Seq_HESCs_Human0.66328462
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66242607
138PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.65498574
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.65256940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.50768353
2MP0006292_abnormal_olfactory_placode4.36945980
3MP0002837_dystrophic_cardiac_calcinosis3.93992424
4MP0004264_abnormal_extraembryonic_tissu3.93073527
5MP0004957_abnormal_blastocyst_morpholog3.83859107
6MP0008057_abnormal_DNA_replication3.49901891
7MP0002254_reproductive_system_inflammat3.36696164
8MP0003890_abnormal_embryonic-extraembry3.33064919
9MP0005499_abnormal_olfactory_system3.28422065
10MP0005394_taste/olfaction_phenotype3.28422065
11MP0006035_abnormal_mitochondrial_morpho3.21908568
12MP0003122_maternal_imprinting3.13471538
13MP0005075_abnormal_melanosome_morpholog3.13228177
14MP0002332_abnormal_exercise_endurance3.05039786
15MP0009697_abnormal_copulation2.49807683
16MP0004858_abnormal_nervous_system2.44805641
17MP0003121_genomic_imprinting2.40735446
18MP0003646_muscle_fatigue2.30167651
19MP0003693_abnormal_embryo_hatching2.20411923
20MP0003123_paternal_imprinting2.14906202
21MP0002277_abnormal_respiratory_mucosa2.11422693
22MP0008877_abnormal_DNA_methylation2.08106708
23MP0003077_abnormal_cell_cycle2.05388831
24MP0002653_abnormal_ependyma_morphology1.93614497
25MP0000678_abnormal_parathyroid_gland1.86955574
26MP0003938_abnormal_ear_development1.84610026
27MP0003111_abnormal_nucleus_morphology1.84364571
28MP0005257_abnormal_intraocular_pressure1.80193182
29MP0005380_embryogenesis_phenotype1.79965228
30MP0001672_abnormal_embryogenesis/_devel1.79965228
31MP0004215_abnormal_myocardial_fiber1.75473324
32MP0010094_abnormal_chromosome_stability1.75075787
33MP0002127_abnormal_cardiovascular_syste1.73952722
34MP0006072_abnormal_retinal_apoptosis1.72368446
35MP0008875_abnormal_xenobiotic_pharmacok1.70982536
36MP0008932_abnormal_embryonic_tissue1.67811321
37MP0005266_abnormal_metabolism1.66922371
38MP0006036_abnormal_mitochondrial_physio1.66014308
39MP0002088_abnormal_embryonic_growth/wei1.64732610
40MP0003984_embryonic_growth_retardation1.63966174
41MP0002160_abnormal_reproductive_system1.60819703
42MP0001764_abnormal_homeostasis1.59898055
43MP0008789_abnormal_olfactory_epithelium1.53911973
44MP0000350_abnormal_cell_proliferation1.53002043
45MP0002938_white_spotting1.49871104
46MP0003195_calcinosis1.49374319
47MP0004084_abnormal_cardiac_muscle1.48441541
48MP0002132_abnormal_respiratory_system1.48258785
49MP0005330_cardiomyopathy1.48143726
50MP0010030_abnormal_orbit_morphology1.43978273
51MP0010352_gastrointestinal_tract_polyps1.43501648
52MP0003183_abnormal_peptide_metabolism1.40215241
53MP0004145_abnormal_muscle_electrophysio1.40166628
54MP0008995_early_reproductive_senescence1.39544434
55MP0002102_abnormal_ear_morphology1.39129694
56MP0001293_anophthalmia1.37502363
57MP0004043_abnormal_pH_regulation1.35340452
58MP0003315_abnormal_perineum_morphology1.31870339
59MP0006082_CNS_inflammation1.30826606
60MP0000762_abnormal_tongue_morphology1.27948882
61MP0003137_abnormal_impulse_conducting1.27626077
62MP0009379_abnormal_foot_pigmentation1.27392030
63MP0002210_abnormal_sex_determination1.23427843
64MP0000049_abnormal_middle_ear1.23194246
65MP0005084_abnormal_gallbladder_morpholo1.23004308
66MP0003786_premature_aging1.21662841
67MP0002638_abnormal_pupillary_reflex1.21265532
68MP0004036_abnormal_muscle_relaxation1.20806768
69MP0001929_abnormal_gametogenesis1.19707363
70MP0001984_abnormal_olfaction1.15490432
71MP0003806_abnormal_nucleotide_metabolis1.15484000
72MP0005332_abnormal_amino_acid1.14267980
73MP0002396_abnormal_hematopoietic_system1.14237659
74MP0000490_abnormal_crypts_of1.13319098
75MP0001730_embryonic_growth_arrest1.13071539
76MP0002085_abnormal_embryonic_tissue1.12794604
77MP0004133_heterotaxia1.09306763
78MP0000313_abnormal_cell_death1.08655187
79MP0000749_muscle_degeneration1.08234961
80MP0008007_abnormal_cellular_replicative1.08093383
81MP0008058_abnormal_DNA_repair1.07849717
82MP0002234_abnormal_pharynx_morphology1.07414245
83MP0000750_abnormal_muscle_regeneration1.06805415
84MP0003567_abnormal_fetal_cardiomyocyte1.06523404
85MP0002086_abnormal_extraembryonic_tissu1.05118543
86MP0002932_abnormal_joint_morphology1.04410526
87MP0003186_abnormal_redox_activity1.03931757
88MP0004381_abnormal_hair_follicle1.02454936
89MP0000358_abnormal_cell_content/1.00141356
90MP0002751_abnormal_autonomic_nervous0.99854957
91MP0002233_abnormal_nose_morphology0.99303439
92MP0000653_abnormal_sex_gland0.98272692
93MP0002092_abnormal_eye_morphology0.97187314
94MP0005389_reproductive_system_phenotype0.96369293
95MP0005379_endocrine/exocrine_gland_phen0.96288926
96MP0003119_abnormal_digestive_system0.96131631
97MP0002114_abnormal_axial_skeleton0.95443288
98MP0001697_abnormal_embryo_size0.93170356
99MP0003941_abnormal_skin_development0.93039274
100MP0001348_abnormal_lacrimal_gland0.90583821
101MP0005645_abnormal_hypothalamus_physiol0.90420161
102MP0004147_increased_porphyrin_level0.90258172
103MP0005410_abnormal_fertilization0.89838482
104MP0002090_abnormal_vision0.88170386
105MP0004142_abnormal_muscle_tone0.87845713
106MP0008961_abnormal_basal_metabolism0.87802754
107MP0002080_prenatal_lethality0.87779469
108MP0002163_abnormal_gland_morphology0.87546779
109MP0003787_abnormal_imprinting0.85680199
110MP0003698_abnormal_male_reproductive0.85524084
111MP0002084_abnormal_developmental_patter0.84741162
112MP0002970_abnormal_white_adipose0.84635407
113MP0003718_maternal_effect0.83812724
114MP0001661_extended_life_span0.83323427
115MP0008775_abnormal_heart_ventricle0.82704283
116MP0001485_abnormal_pinna_reflex0.82083070
117MP0008872_abnormal_physiological_respon0.81917592
118MP0002269_muscular_atrophy0.78611339
119MP0005551_abnormal_eye_electrophysiolog0.78014681
120MP0001849_ear_inflammation0.77816874
121MP0005646_abnormal_pituitary_gland0.75249506
122MP0005408_hypopigmentation0.74750149
123MP0003755_abnormal_palate_morphology0.73687486
124MP0005391_vision/eye_phenotype0.73066017
125MP0001529_abnormal_vocalization0.72125852
126MP0005376_homeostasis/metabolism_phenot0.71500041
127MP0006276_abnormal_autonomic_nervous0.70991781
128MP0000631_abnormal_neuroendocrine_gland0.70871159
129MP0000432_abnormal_head_morphology0.69379720
130MP0001919_abnormal_reproductive_system0.69014464
131MP0008770_decreased_survivor_rate0.68142252
132MP0001119_abnormal_female_reproductive0.67997482
133MP0005395_other_phenotype0.67889347
134MP0003136_yellow_coat_color0.67286138
135MP0009046_muscle_twitch0.67018541
136MP0005360_urolithiasis0.65296049
137MP0001905_abnormal_dopamine_level0.64614479
138MP0003937_abnormal_limbs/digits/tail_de0.64580345
139MP0000516_abnormal_urinary_system0.62777261
140MP0005367_renal/urinary_system_phenotyp0.62777261
141MP0003705_abnormal_hypodermis_morpholog0.60670113
142MP0004197_abnormal_fetal_growth/weight/0.59988262
143MP0000428_abnormal_craniofacial_morphol0.57977753
144MP0002019_abnormal_tumor_incidence0.56620941
145MP0003935_abnormal_craniofacial_develop0.55880037
146MP0001145_abnormal_male_reproductive0.55860492
147MP0001286_abnormal_eye_development0.53902219
148MP0005384_cellular_phenotype0.53744268
149MP0005253_abnormal_eye_physiology0.52730058
150MP0000372_irregular_coat_pigmentation0.51884654
151MP0004782_abnormal_surfactant_physiolog0.51879048

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.70821176
2Multiple enchondromatosis (HP:0005701)5.51531663
3Hypochromic microcytic anemia (HP:0004840)5.29469559
4Mitochondrial inheritance (HP:0001427)4.87496815
5Progressive macrocephaly (HP:0004481)4.49552880
6Hepatoblastoma (HP:0002884)4.37526168
7Hepatocellular necrosis (HP:0001404)4.36740722
8Lipid accumulation in hepatocytes (HP:0006561)4.31427602
9Hepatic necrosis (HP:0002605)4.29283249
10Increased hepatocellular lipid droplets (HP:0006565)4.29235313
11Cerebral edema (HP:0002181)4.05047512
12Rib fusion (HP:0000902)3.99869024
13Abnormality of glycolysis (HP:0004366)3.76234045
14Increased serum pyruvate (HP:0003542)3.76234045
15Abnormality of the lower motor neuron (HP:0002366)3.75007829
16Ependymoma (HP:0002888)3.73427498
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72083324
18Rhabdomyosarcoma (HP:0002859)3.66288828
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.62893147
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.62893147
21Ragged-red muscle fibers (HP:0003200)3.60838693
22Rectovaginal fistula (HP:0000143)3.58028350
23Rectal fistula (HP:0100590)3.58028350
24Nephroblastoma (Wilms tumor) (HP:0002667)3.54691128
25Renal Fanconi syndrome (HP:0001994)3.49757588
263-Methylglutaconic aciduria (HP:0003535)3.49619298
27Testicular atrophy (HP:0000029)3.45308590
28Neoplasm of striated muscle (HP:0009728)3.42800519
29Increased intramyocellular lipid droplets (HP:0012240)3.41392869
30Chromsome breakage (HP:0040012)3.41309790
31Lactic acidosis (HP:0003128)3.34969114
32Partial duplication of thumb phalanx (HP:0009944)3.32798802
33Trismus (HP:0000211)3.32737063
34Embryonal renal neoplasm (HP:0011794)3.26483087
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.25674436
36Hypoplasia of the fovea (HP:0007750)3.25674436
37Microvesicular hepatic steatosis (HP:0001414)3.10321394
38Increased muscle lipid content (HP:0009058)3.10277705
39Exercise intolerance (HP:0003546)3.08439710
40Abnormal lung lobation (HP:0002101)3.07838363
41Vaginal fistula (HP:0004320)2.98526306
42Intestinal fistula (HP:0100819)2.96053231
43Fused cervical vertebrae (HP:0002949)2.93210055
44Reduced antithrombin III activity (HP:0001976)2.91657434
45Anomalous pulmonary venous return (HP:0010772)2.89668174
46Respiratory failure (HP:0002878)2.87305357
47Bifid tongue (HP:0010297)2.82887143
48Partial duplication of the phalanx of hand (HP:0009999)2.82753057
49Progressive external ophthalmoplegia (HP:0000590)2.78630442
50Microretrognathia (HP:0000308)2.74221228
51Aplasia/hypoplasia of the humerus (HP:0006507)2.73426482
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72754276
53Abnormal cartilage morphology (HP:0002763)2.72587104
54Sensory axonal neuropathy (HP:0003390)2.72394972
55Hyperventilation (HP:0002883)2.71124134
56Impulsivity (HP:0100710)2.68873906
57Amyotrophic lateral sclerosis (HP:0007354)2.67511725
58Abnormal glycosylation (HP:0012345)2.65953941
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65953941
60Abnormal protein N-linked glycosylation (HP:0012347)2.65953941
61Abnormal protein glycosylation (HP:0012346)2.65953941
62Lethargy (HP:0001254)2.64782539
63Meckel diverticulum (HP:0002245)2.64626168
64Progressive muscle weakness (HP:0003323)2.59545078
65Hyperinsulinemic hypoglycemia (HP:0000825)2.57028254
66Optic disc pallor (HP:0000543)2.54846549
67Horizontal nystagmus (HP:0000666)2.54630386
68Abnormal number of erythroid precursors (HP:0012131)2.54103973
69Supernumerary spleens (HP:0009799)2.52050271
70Abnormality of the salivary glands (HP:0010286)2.51915690
71Hyperglycinemia (HP:0002154)2.50335791
72CNS demyelination (HP:0007305)2.48526092
73Generalized aminoaciduria (HP:0002909)2.47317857
74Exertional dyspnea (HP:0002875)2.47262137
75Abnormality of cells of the erythroid lineage (HP:0012130)2.46929708
76Abnormality of the ileum (HP:0001549)2.46786583
77Leukodystrophy (HP:0002415)2.45259696
78Short humerus (HP:0005792)2.44415123
79Glossoptosis (HP:0000162)2.44382905
80Aplastic anemia (HP:0001915)2.43568533
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.43247339
82Nasolacrimal duct obstruction (HP:0000579)2.42724978
83Abnormality of the pulmonary veins (HP:0011718)2.42488130
84Premature ovarian failure (HP:0008209)2.39363189
85Type I transferrin isoform profile (HP:0003642)2.38638748
86Abnormality of the fovea (HP:0000493)2.36263215
87Respiratory difficulties (HP:0002880)2.35760138
88Colon cancer (HP:0003003)2.32685720
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31429881
90Tongue fasciculations (HP:0001308)2.29939539
91Abnormality of the astrocytes (HP:0100707)2.26613066
92Astrocytoma (HP:0009592)2.26613066
93Acute necrotizing encephalopathy (HP:0006965)2.25584305
94Reticulocytopenia (HP:0001896)2.25474637
95Abnormality of alanine metabolism (HP:0010916)2.24444723
96Hyperalaninemia (HP:0003348)2.24444723
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24444723
98Abnormality of urine glucose concentration (HP:0011016)2.23716196
99Glycosuria (HP:0003076)2.23716196
100Periauricular skin pits (HP:0100277)2.22822302
101Preauricular pit (HP:0004467)2.22822302
102Macrocytic anemia (HP:0001972)2.18605002
103Atrophy/Degeneration involving motor neurons (HP:0007373)2.17312775
104Methylmalonic aciduria (HP:0012120)2.16912395
105Cheilitis (HP:0100825)2.16375121
106Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15236490
107Methylmalonic acidemia (HP:0002912)2.13722854
108Hyperglycinuria (HP:0003108)2.13519242
109Generalized hypotonia (HP:0001290)2.13255019
110Secondary amenorrhea (HP:0000869)2.11473538
111Absent thumb (HP:0009777)2.11259293
112Abnormality of the phalanges of the hallux (HP:0010057)2.10831583
113Hypoglycemic coma (HP:0001325)2.09723293
114Preauricular skin tag (HP:0000384)2.07980194
115Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07775655
116Dicarboxylic aciduria (HP:0003215)2.07775655
117Pancytopenia (HP:0001876)2.06848893
118Abnormality of serum amino acid levels (HP:0003112)2.06342951
119Abnormality of the preputium (HP:0100587)2.06002826
120Hypochromic anemia (HP:0001931)2.05598782
121Molar tooth sign on MRI (HP:0002419)2.05353490
122Abnormality of midbrain morphology (HP:0002418)2.05353490
123Muscle fibrillation (HP:0010546)2.05314014
124Abnormality of small intestinal villus morphology (HP:0011472)2.04827123
125Villous atrophy (HP:0011473)2.04827123
126Facial cleft (HP:0002006)2.04573518
127Duodenal stenosis (HP:0100867)2.04356731
128Small intestinal stenosis (HP:0012848)2.04356731
129Tetraplegia (HP:0002445)2.01267147
130Shawl scrotum (HP:0000049)2.00940079
131Increased CSF lactate (HP:0002490)2.00852543
132Abnormal biliary tract physiology (HP:0012439)1.99501948
133Bile duct proliferation (HP:0001408)1.99501948
134Pancreatic cysts (HP:0001737)1.97655771
135Duplication of thumb phalanx (HP:0009942)1.97311877
136Abnormality of renal resorption (HP:0011038)1.97255853
137Abnormal mitochondria in muscle tissue (HP:0008316)1.97135503
138Pancreatic fibrosis (HP:0100732)1.96825856
139Sparse eyelashes (HP:0000653)1.95808967
140CNS hypomyelination (HP:0003429)1.95111686
141Malnutrition (HP:0004395)1.94662807
142Adenoma sebaceum (HP:0009720)1.94627040
143Angiofibromas (HP:0010615)1.94627040
144Combined immunodeficiency (HP:0005387)1.92319729
145Abnormality of methionine metabolism (HP:0010901)1.92169004
146Abnormality of serine family amino acid metabolism (HP:0010894)1.92081437
147Abnormality of glycine metabolism (HP:0010895)1.92081437
148Nausea (HP:0002018)1.91240484
149Aplasia/Hypoplasia of the macula (HP:0008059)1.90974808
150Pendular nystagmus (HP:0012043)1.90521981
151True hermaphroditism (HP:0010459)1.89896052
152Emotional lability (HP:0000712)1.89768544
153Hypoplasia of the pons (HP:0012110)1.89766821
154Medulloblastoma (HP:0002885)1.89368459
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.88762270
156Abnormality of the labia minora (HP:0012880)1.86940132
157Acute encephalopathy (HP:0006846)1.83636166
158Malignant neoplasm of the central nervous system (HP:0100836)1.82143202
159Birth length less than 3rd percentile (HP:0003561)1.81926088
160Increased serum lactate (HP:0002151)1.81489572
161Abnormality of chromosome segregation (HP:0002916)1.80671853
162Abnormality of chromosome stability (HP:0003220)1.80217229
163Cerebral hypomyelination (HP:0006808)1.80183560
164Breast hypoplasia (HP:0003187)1.79409654
165Hyperphosphaturia (HP:0003109)1.75549728
166Carpal bone hypoplasia (HP:0001498)1.72307143
167X-linked dominant inheritance (HP:0001423)1.72225893
168Progressive microcephaly (HP:0000253)1.68658251
169Vomiting (HP:0002013)1.67883759
170Neoplasm of the adrenal gland (HP:0100631)1.67298201
171Degeneration of anterior horn cells (HP:0002398)1.67048208
172Abnormality of the anterior horn cell (HP:0006802)1.67048208
173Abnormality of the pons (HP:0007361)1.66644330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.10379360
2GRK55.57022349
3GRK64.21665344
4VRK24.02078410
5ADRBK23.46551934
6ERN13.40201262
7GRK13.19233709
8TTK3.07785528
9ZAK3.05542474
10GRK72.91050350
11CSF1R2.70725404
12BUB12.69818471
13PINK12.51276619
14NUAK12.10434204
15MAPK72.05704969
16MATK2.04953982
17TGFBR22.01388230
18MOS1.91122800
19TYRO31.86116220
20BMPR1B1.77761450
21STK101.75419106
22TRIM281.70488239
23OBSCN1.63001628
24CDK71.61150651
25WEE11.60027690
26PLK11.59573330
27PRKG21.58551069
28WNK11.56723053
29AKT31.47105888
30CHEK21.45831646
31EPHA21.28308959
32NME21.26647762
33TAF11.26591682
34WNK31.22386638
35EIF2AK11.22237275
36STK161.21840772
37ADRBK11.19119503
38CAMK41.16744151
39SRPK11.16044129
40CSNK1G31.10725908
41NTRK11.09967887
42PAK41.08253108
43MAP2K41.05859809
44MAP4K21.05005015
45MKNK21.02462523
46NME11.02361451
47MAP2K71.00896505
48EIF2AK20.97866781
49CSNK1G10.95600457
50MKNK10.94301844
51CDC70.94292314
52FRK0.91880246
53AURKA0.91184531
54CSNK1A1L0.90662917
55CSNK1G20.86033374
56MUSK0.83393962
57MAP2K60.82674533
58MARK30.82368752
59CHEK10.79881904
60VRK10.76903717
61TESK20.75847554
62TIE10.75014199
63MAP3K120.74824522
64TNIK0.74430737
65MARK20.73502171
66PHKG20.71379678
67PHKG10.71379678
68PRKCI0.70433240
69DYRK20.70431599
70INSRR0.70319141
71RPS6KA50.69259773
72MST40.68951671
73AURKB0.67129044
74AKT20.64584109
75NEK10.61113069
76TLK10.61007473
77CDK80.60664021
78HIPK20.59560955
79EIF2AK30.58579084
80STK40.57581660
81NEK20.56875562
82KDR0.54837314
83MAP3K100.54391394
84PLK20.54192240
85DAPK30.53613821
86RPS6KA40.53328885
87MAPK120.52582333
88PAK10.52438510
89RPS6KB20.50427107
90MINK10.49597007
91DAPK10.47879367
92BRSK20.47775659
93BCR0.47743557
94PDK40.47123194
95PDK30.47123194
96ERBB30.46849976
97CDK20.46687616
98MAP3K50.45664389
99BCKDK0.45503085
100MAPKAPK30.45410240
101PLK40.45403700
102ARAF0.44544432
103ALK0.44106006
104LIMK10.44067554
105STK390.43685194
106MYLK0.40451546
107MAPK130.38824608
108OXSR10.38468470
109CCNB10.37617522
110BRAF0.37589107
111CDK150.36316735
112CDK180.36268943
113CDK11A0.36222390
114ATM0.35596031
115CSNK1A10.35510401
116CSNK1E0.35500833
117LATS20.34750405
118DYRK30.34504740
119PRKCD0.34502267
120FGFR30.34095859
121TSSK60.32341263
122BRSK10.31334171
123ILK0.30504117
124PIM20.30489988
125ACVR1B0.30468480
126CSNK2A10.30136532
127PRKCG0.30108023
128CSK0.29915580
129CDK10.29551377
130STK30.28482984
131CDK30.28463039
132MAPK40.27621643
133PDK20.26836592
134IGF1R0.26113447
135CDK140.25417863
136CDK190.25206766
137STK38L0.24983386
138PRKACA0.23076170
139CDK40.22861340
140IKBKB0.22671405
141PLK30.22239153
142CSNK2A20.21746075
143DYRK1A0.20686396
144ABL20.20330646
145ATR0.19857937
146PRKACB0.17828894
147PBK0.16825858

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.36615287
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.43126896
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.00479559
4Ribosome_Homo sapiens_hsa030103.69818618
5Fructose and mannose metabolism_Homo sapiens_hsa000513.08665354
6Proteasome_Homo sapiens_hsa030502.96019674
7RNA polymerase_Homo sapiens_hsa030202.89620401
8Oxidative phosphorylation_Homo sapiens_hsa001902.88631054
9Parkinsons disease_Homo sapiens_hsa050122.52840046
10DNA replication_Homo sapiens_hsa030302.42043135
11Mismatch repair_Homo sapiens_hsa034302.34505455
12RNA transport_Homo sapiens_hsa030132.24542944
13Arachidonic acid metabolism_Homo sapiens_hsa005902.13150679
14Homologous recombination_Homo sapiens_hsa034402.02603186
15Huntingtons disease_Homo sapiens_hsa050161.96106817
16Spliceosome_Homo sapiens_hsa030401.88632856
17Galactose metabolism_Homo sapiens_hsa000521.86345854
18Propanoate metabolism_Homo sapiens_hsa006401.84585278
19Pyrimidine metabolism_Homo sapiens_hsa002401.77305455
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76586795
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72020838
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69181252
23Alzheimers disease_Homo sapiens_hsa050101.66576578
24Linoleic acid metabolism_Homo sapiens_hsa005911.63791868
25Fanconi anemia pathway_Homo sapiens_hsa034601.61742732
26Basal transcription factors_Homo sapiens_hsa030221.56208953
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55994061
28Base excision repair_Homo sapiens_hsa034101.42563731
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39432230
30Nucleotide excision repair_Homo sapiens_hsa034201.38512276
31RNA degradation_Homo sapiens_hsa030181.37866505
32Fatty acid elongation_Homo sapiens_hsa000621.35969318
33Cell cycle_Homo sapiens_hsa041101.31695704
34One carbon pool by folate_Homo sapiens_hsa006701.27691841
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26924409
36Cardiac muscle contraction_Homo sapiens_hsa042601.26809816
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15113248
38mRNA surveillance pathway_Homo sapiens_hsa030151.14960550
39Folate biosynthesis_Homo sapiens_hsa007901.08007740
40Pentose phosphate pathway_Homo sapiens_hsa000301.06963491
41Butanoate metabolism_Homo sapiens_hsa006501.05653305
42Carbon metabolism_Homo sapiens_hsa012001.01772263
43Peroxisome_Homo sapiens_hsa041460.97163115
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93380699
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92935677
46Regulation of autophagy_Homo sapiens_hsa041400.88470684
47Fatty acid degradation_Homo sapiens_hsa000710.82056751
48Steroid biosynthesis_Homo sapiens_hsa001000.81569259
49Thyroid cancer_Homo sapiens_hsa052160.81001713
50Sulfur metabolism_Homo sapiens_hsa009200.79021129
51Metabolic pathways_Homo sapiens_hsa011000.76835877
52Purine metabolism_Homo sapiens_hsa002300.76343159
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74833536
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74612262
55Chemical carcinogenesis_Homo sapiens_hsa052040.72251221
56Fatty acid metabolism_Homo sapiens_hsa012120.71247542
57Non-homologous end-joining_Homo sapiens_hsa034500.68556689
58Ether lipid metabolism_Homo sapiens_hsa005650.68468368
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.68303748
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64770225
61Sulfur relay system_Homo sapiens_hsa041220.64352116
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63930811
63Biosynthesis of amino acids_Homo sapiens_hsa012300.63841155
64beta-Alanine metabolism_Homo sapiens_hsa004100.63176098
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62055176
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60243953
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.58226901
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.58213936
69p53 signaling pathway_Homo sapiens_hsa041150.56578359
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55718486
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55508752
72Caffeine metabolism_Homo sapiens_hsa002320.53927966
73Nitrogen metabolism_Homo sapiens_hsa009100.53340230
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52045885
75Other glycan degradation_Homo sapiens_hsa005110.51465982
76Systemic lupus erythematosus_Homo sapiens_hsa053220.51363939
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50661282
78Glutathione metabolism_Homo sapiens_hsa004800.49781729
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.49180314
80Phototransduction_Homo sapiens_hsa047440.46908952
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.46708364
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46612214
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46172242
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45537910
85Arginine biosynthesis_Homo sapiens_hsa002200.45296271
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42118629
87Protein export_Homo sapiens_hsa030600.42069646
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38824729
89Tryptophan metabolism_Homo sapiens_hsa003800.37315273
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37272409
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.35324736
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.33555170
93Pyruvate metabolism_Homo sapiens_hsa006200.31559112
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31263691
95N-Glycan biosynthesis_Homo sapiens_hsa005100.29501027
96Herpes simplex infection_Homo sapiens_hsa051680.24004282
97mTOR signaling pathway_Homo sapiens_hsa041500.24001436
98African trypanosomiasis_Homo sapiens_hsa051430.22874618
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22051644
100Taste transduction_Homo sapiens_hsa047420.21231245
101Collecting duct acid secretion_Homo sapiens_hsa049660.21074072
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19074067
103Inositol phosphate metabolism_Homo sapiens_hsa005620.18739299
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18734692
105Epstein-Barr virus infection_Homo sapiens_hsa051690.18151955
106Vitamin digestion and absorption_Homo sapiens_hsa049770.17972054
107Mineral absorption_Homo sapiens_hsa049780.17933921
108Tyrosine metabolism_Homo sapiens_hsa003500.17740522
109Fat digestion and absorption_Homo sapiens_hsa049750.17480247
110Olfactory transduction_Homo sapiens_hsa047400.17156990
111Oocyte meiosis_Homo sapiens_hsa041140.15881280
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15788450
113Selenocompound metabolism_Homo sapiens_hsa004500.15614331
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.15060824
115Ovarian steroidogenesis_Homo sapiens_hsa049130.14747096
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12610692
117Retinol metabolism_Homo sapiens_hsa008300.12421242
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11644419
119Serotonergic synapse_Homo sapiens_hsa047260.11125867
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10093816
121Pathways in cancer_Homo sapiens_hsa052000.08879631
122Hedgehog signaling pathway_Homo sapiens_hsa043400.08848468
123Arginine and proline metabolism_Homo sapiens_hsa003300.05013423
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03793283
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03374615
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.03287838
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.02728294
128Phenylalanine metabolism_Homo sapiens_hsa003600.02021586
129Basal cell carcinoma_Homo sapiens_hsa052170.01089813

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »