MRPL48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.08722739
2axon ensheathment in central nervous system (GO:0032291)6.08722739
3mitochondrial respiratory chain complex assembly (GO:0033108)4.54465029
4long-chain fatty acid biosynthetic process (GO:0042759)4.44006835
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19480318
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.17515904
7proteasome assembly (GO:0043248)4.06468597
8DNA deamination (GO:0045006)3.88971478
9chaperone-mediated protein transport (GO:0072321)3.82137784
10water-soluble vitamin biosynthetic process (GO:0042364)3.78389704
11superoxide anion generation (GO:0042554)3.78310325
12GPI anchor biosynthetic process (GO:0006506)3.77798161
13response to pheromone (GO:0019236)3.71333647
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70685341
15cytochrome complex assembly (GO:0017004)3.70479823
16preassembly of GPI anchor in ER membrane (GO:0016254)3.67343847
17presynaptic membrane assembly (GO:0097105)3.64009060
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62507070
19presynaptic membrane organization (GO:0097090)3.61440387
20behavioral response to nicotine (GO:0035095)3.57081532
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56335830
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50313685
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50313685
24termination of RNA polymerase III transcription (GO:0006386)3.49641014
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.49641014
26GPI anchor metabolic process (GO:0006505)3.48764683
27limb bud formation (GO:0060174)3.48653219
28positive regulation of action potential (GO:0045760)3.47216789
29ubiquinone biosynthetic process (GO:0006744)3.42693553
30protein-cofactor linkage (GO:0018065)3.37022141
31peptidyl-histidine modification (GO:0018202)3.28915515
32response to redox state (GO:0051775)3.26948856
33cullin deneddylation (GO:0010388)3.24446461
34regulation of mitochondrial translation (GO:0070129)3.22419010
35neuron cell-cell adhesion (GO:0007158)3.21294258
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21020051
37righting reflex (GO:0060013)3.19812165
38pseudouridine synthesis (GO:0001522)3.19189035
39fatty acid elongation (GO:0030497)3.19122491
40L-amino acid import (GO:0043092)3.19006843
41ubiquinone metabolic process (GO:0006743)3.13626345
42ATP biosynthetic process (GO:0006754)3.13493092
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13299162
44protein deneddylation (GO:0000338)3.12956116
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11884533
46keratinocyte development (GO:0003334)3.09607085
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09558720
48DNA double-strand break processing (GO:0000729)3.09259665
49hydrogen ion transmembrane transport (GO:1902600)3.08598018
50rRNA modification (GO:0000154)3.07212990
51glycerophospholipid catabolic process (GO:0046475)3.05790141
52ribosomal small subunit assembly (GO:0000028)3.05141444
53respiratory electron transport chain (GO:0022904)3.04255112
54reflex (GO:0060004)3.02240020
55maturation of 5.8S rRNA (GO:0000460)3.01216298
56negative regulation of protein localization to cell surface (GO:2000009)2.99388785
57startle response (GO:0001964)2.98102939
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97425905
59platelet dense granule organization (GO:0060155)2.96802131
60electron transport chain (GO:0022900)2.94973832
61tRNA processing (GO:0008033)2.94803172
62import into cell (GO:0098657)2.92393756
63protein neddylation (GO:0045116)2.92359078
64regulation of cellular amino acid metabolic process (GO:0006521)2.91690470
65protein K6-linked ubiquitination (GO:0085020)2.91599201
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91217396
67chromatin remodeling at centromere (GO:0031055)2.90467101
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90423029
69eye photoreceptor cell differentiation (GO:0001754)2.90263943
70photoreceptor cell differentiation (GO:0046530)2.90263943
71proton transport (GO:0015992)2.88585805
72mitochondrial RNA metabolic process (GO:0000959)2.87943249
73translational termination (GO:0006415)2.87765926
74negative regulation of neurotransmitter transport (GO:0051589)2.87043717
75translation (GO:0006412)2.86219420
76negative regulation of myoblast differentiation (GO:0045662)2.85810514
77neuron remodeling (GO:0016322)2.85385664
78ATP synthesis coupled proton transport (GO:0015986)2.85226195
79energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85226195
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85047877
81viral transcription (GO:0019083)2.84719307
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84371633
83cyclic nucleotide catabolic process (GO:0009214)2.84122745
84G-protein coupled receptor internalization (GO:0002031)2.83623067
85cotranslational protein targeting to membrane (GO:0006613)2.83215681
86CENP-A containing nucleosome assembly (GO:0034080)2.83040099
87replication fork processing (GO:0031297)2.82801764
88hydrogen transport (GO:0006818)2.82409506
89cerebral cortex radially oriented cell migration (GO:0021799)2.82170385
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80991541
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80991541
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80991541
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80049722
94protein targeting to mitochondrion (GO:0006626)2.79348802
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78311460
96negative regulation of ligase activity (GO:0051352)2.78311460
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77823071
98oxidative phosphorylation (GO:0006119)2.76430237
99protein targeting to ER (GO:0045047)2.76329612
100amino acid salvage (GO:0043102)2.75644454
101L-methionine salvage (GO:0071267)2.75644454
102L-methionine biosynthetic process (GO:0071265)2.75644454
103protein complex biogenesis (GO:0070271)2.75384260
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75376696
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75376696
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75155797
107cellular ketone body metabolic process (GO:0046950)2.74985133
108cellular component biogenesis (GO:0044085)2.74684114
109intracellular protein transmembrane import (GO:0044743)2.73686889
110quinone biosynthetic process (GO:1901663)2.71970332
111organelle disassembly (GO:1903008)2.71586202
112ribosomal large subunit biogenesis (GO:0042273)2.71007197
113establishment of protein localization to mitochondrion (GO:0072655)2.70336296
114glycolipid biosynthetic process (GO:0009247)2.69978798
115ketone body metabolic process (GO:1902224)2.69565971
116myelination (GO:0042552)2.68749322
117nucleotide transmembrane transport (GO:1901679)2.68415813
118mannosylation (GO:0097502)2.68317243
119positive regulation of protein homodimerization activity (GO:0090073)2.68264226
120signal transduction involved in cell cycle checkpoint (GO:0072395)2.67671697
121protein localization to mitochondrion (GO:0070585)2.67468665
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67165370
123signal transduction involved in DNA damage checkpoint (GO:0072422)2.67165370
124inner ear receptor stereocilium organization (GO:0060122)2.65131492
125recombinational repair (GO:0000725)2.65121788
126protein localization to endoplasmic reticulum (GO:0070972)2.64342792
127oligodendrocyte differentiation (GO:0048709)2.64249117
128establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63991515
129regulation of pigment cell differentiation (GO:0050932)2.62774794
130centriole assembly (GO:0098534)2.62585380
131opioid receptor signaling pathway (GO:0038003)2.62014918
132ensheathment of neurons (GO:0007272)2.61076838
133axon ensheathment (GO:0008366)2.61076838
134photoreceptor cell maintenance (GO:0045494)2.60879075
135translational elongation (GO:0006414)2.60537575
136rRNA methylation (GO:0031167)2.60450171
137nucleoside triphosphate biosynthetic process (GO:0009142)2.59982403
138double-strand break repair via homologous recombination (GO:0000724)2.59931990
139regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59632877
140detection of mechanical stimulus involved in sensory perception (GO:0050974)2.59352531
141DNA integration (GO:0015074)2.58799973
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58332263
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.58332263
144NADH dehydrogenase complex assembly (GO:0010257)2.58332263
145positive regulation of uterine smooth muscle contraction (GO:0070474)2.57998439
146transmission of nerve impulse (GO:0019226)2.57388111
147histone H2B ubiquitination (GO:0033523)2.55242157
148adenosine metabolic process (GO:0046085)2.53443471
149cranial nerve morphogenesis (GO:0021602)2.53054815
150response to epinephrine (GO:0071871)2.52698527
151regulation of timing of cell differentiation (GO:0048505)2.51432416
152mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51092877
153mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51092877
154neuronal action potential propagation (GO:0019227)2.50439427
155sphingoid metabolic process (GO:0046519)2.49961169
156auditory receptor cell stereocilium organization (GO:0060088)2.49345410
157C-terminal protein lipidation (GO:0006501)2.48922156
158C-terminal protein amino acid modification (GO:0018410)2.47315138
159purine ribonucleotide transport (GO:0015868)2.47215370
160developmental pigmentation (GO:0048066)2.45708065
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44811899
162regulation of feeding behavior (GO:0060259)2.43220147
163negative regulation of keratinocyte proliferation (GO:0010839)2.42381026
164polyol transport (GO:0015791)2.41291373
165nonmotile primary cilium assembly (GO:0035058)2.40777069
166ionotropic glutamate receptor signaling pathway (GO:0035235)2.39974691
167adult walking behavior (GO:0007628)2.38912934
168nucleotide transport (GO:0006862)2.38221891
169cAMP catabolic process (GO:0006198)2.38134089
170cilium movement (GO:0003341)2.38077736
171GTP biosynthetic process (GO:0006183)2.37168882
172negative regulation of execution phase of apoptosis (GO:1900118)2.37034297
173androgen biosynthetic process (GO:0006702)2.35160277
174cranial nerve development (GO:0021545)2.35132022
175glutamate receptor signaling pathway (GO:0007215)2.34554014
176postsynaptic membrane organization (GO:0001941)2.33880596
177detection of light stimulus involved in sensory perception (GO:0050962)2.33348670
178detection of light stimulus involved in visual perception (GO:0050908)2.33348670
179cellular response to epinephrine stimulus (GO:0071872)2.33269264
180positive regulation of cellular amine metabolic process (GO:0033240)2.32532689
181neurotransmitter uptake (GO:0001504)2.31571230
182diol metabolic process (GO:0034311)2.30247692
183adenine nucleotide transport (GO:0051503)2.30055340
184protein localization to cilium (GO:0061512)2.29612650
185respiratory chain complex IV assembly (GO:0008535)2.28972171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75783140
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.32871089
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.96517267
4GBX2_23144817_ChIP-Seq_PC3_Human3.93608097
5EZH2_22144423_ChIP-Seq_EOC_Human3.85770180
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.49152458
7ZNF274_21170338_ChIP-Seq_K562_Hela3.16268475
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16263724
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.03217872
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90766770
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85875432
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.85142999
13* VDR_23849224_ChIP-Seq_CD4+_Human2.61357081
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.60116470
15ELK1_19687146_ChIP-ChIP_HELA_Human2.50307546
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.46302173
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44334256
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40895896
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37269552
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36698820
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.36291675
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31132132
23TAF15_26573619_Chip-Seq_HEK293_Human2.29502222
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.25115659
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20313188
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17789136
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.17647129
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.17091239
29SUZ12_27294783_Chip-Seq_NPCs_Mouse2.16535884
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11006793
31MYC_18555785_ChIP-Seq_MESCs_Mouse2.09809280
32* FOXP3_21729870_ChIP-Seq_TREG_Human2.08527698
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.08429152
34PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08385647
35* MYC_18940864_ChIP-ChIP_HL60_Human2.06997750
36NFE2_27457419_Chip-Seq_LIVER_Mouse2.04589885
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02528412
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02182205
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01547518
40IGF1R_20145208_ChIP-Seq_DFB_Human1.95474385
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93091809
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83505340
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83020317
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.82734286
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.81828575
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79687490
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79687490
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.79268704
49VDR_22108803_ChIP-Seq_LS180_Human1.78951157
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77713575
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77397758
52P300_19829295_ChIP-Seq_ESCs_Human1.77179940
53P53_22387025_ChIP-Seq_ESCs_Mouse1.76318300
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75387758
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.74104037
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72844616
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.69276896
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69155078
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.67922018
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67617224
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.66850149
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.65619121
63IRF1_19129219_ChIP-ChIP_H3396_Human1.64671699
64FUS_26573619_Chip-Seq_HEK293_Human1.64385515
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64349327
66RNF2_27304074_Chip-Seq_NSC_Mouse1.63529404
67* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62236088
68P300_18555785_Chip-Seq_ESCs_Mouse1.61957412
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.61602325
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61516646
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.61249539
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60481059
73DCP1A_22483619_ChIP-Seq_HELA_Human1.59190409
74* GABP_19822575_ChIP-Seq_HepG2_Human1.58219934
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56450651
76* ER_23166858_ChIP-Seq_MCF-7_Human1.56078696
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.55220588
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55152384
79TTF2_22483619_ChIP-Seq_HELA_Human1.54383131
80AR_21572438_ChIP-Seq_LNCaP_Human1.53725945
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53372886
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52326876
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51690469
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51399039
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51177608
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50442230
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.50070577
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49904084
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.49731089
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48651629
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47594392
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47392180
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.47250158
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.46805234
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45930991
96ZFX_18555785_Chip-Seq_ESCs_Mouse1.45622461
97TP53_22573176_ChIP-Seq_HFKS_Human1.44102571
98SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43186020
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.42666985
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42458166
101PU1_27457419_Chip-Seq_LIVER_Mouse1.41105946
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39216876
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.39205299
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38909558
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.38550637
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38363445
107SMAD4_21799915_ChIP-Seq_A2780_Human1.38318765
108* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36968010
109EWS_26573619_Chip-Seq_HEK293_Human1.36483012
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.36243952
111HTT_18923047_ChIP-ChIP_STHdh_Human1.36085412
112* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35956321
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35628959
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.34433884
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31340926
116XRN2_22483619_ChIP-Seq_HELA_Human1.30300615
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30237130
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28233960
119KDM2B_26808549_Chip-Seq_REH_Human1.27487040
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27155420
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26924200
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26634975
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.25882948
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25589350
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24967731
126REST_21632747_ChIP-Seq_MESCs_Mouse1.22876138
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22654784
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21308128
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21206362
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.21074914
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21074914
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20081587
133HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18170364
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17540247
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17125631
136* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16823066
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16690262
138SALL1_21062744_ChIP-ChIP_HESCs_Human1.13802497
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13707544
140STAT3_23295773_ChIP-Seq_U87_Human1.13069241
141RUNX2_22187159_ChIP-Seq_PCA_Human1.10522565
142TCF4_23295773_ChIP-Seq_U87_Human1.10256125
143* AR_20517297_ChIP-Seq_VCAP_Human1.10157961
144* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08737570
145POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08199169
146DROSHA_22980978_ChIP-Seq_HELA_Human1.07720235
147* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06512396
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06465885
149TP53_18474530_ChIP-ChIP_U2OS_Human1.05952705
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05204945
151GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03622406
152ELK1_22589737_ChIP-Seq_MCF10A_Human1.03621264
153KDM5A_27292631_Chip-Seq_BREAST_Human1.03529030
154E2F7_22180533_ChIP-Seq_HELA_Human1.03506052
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02822753
156NCOR_22424771_ChIP-Seq_293T_Human1.02062636
157NANOG_19829295_ChIP-Seq_ESCs_Human1.01405661
158SOX2_19829295_ChIP-Seq_ESCs_Human1.01405661
159* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99756212
160HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96965950
161MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95727717
162NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95429112
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94579591
164GATA3_21878914_ChIP-Seq_MCF-7_Human0.94426901
165* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94252529
166CBP_20019798_ChIP-Seq_JUKART_Human0.93268448
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93268448
168FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88301227
169FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87137400
170HOXB7_26014856_ChIP-Seq_BT474_Human0.86133338
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85238479
172PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84593214
173CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83289138
174BCAT_22108803_ChIP-Seq_LS180_Human0.81856907
175KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80835797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.53292544
2MP0003880_abnormal_central_pattern3.50460746
3MP0003136_yellow_coat_color3.30227077
4MP0002102_abnormal_ear_morphology3.14663974
5MP0008058_abnormal_DNA_repair2.75039164
6MP0005409_darkened_coat_color2.60083155
7MP0000566_synostosis2.57817814
8MP0001529_abnormal_vocalization2.52587701
9MP0003806_abnormal_nucleotide_metabolis2.50430592
10MP0001486_abnormal_startle_reflex2.46633449
11MP0005171_absent_coat_pigmentation2.41588499
12MP0005451_abnormal_body_composition2.40682608
13MP0004742_abnormal_vestibular_system2.37242668
14MP0008877_abnormal_DNA_methylation2.35180517
15MP0005645_abnormal_hypothalamus_physiol2.33585823
16MP0001905_abnormal_dopamine_level2.30260478
17MP0002837_dystrophic_cardiac_calcinosis2.21792388
18MP0004142_abnormal_muscle_tone2.20412175
19MP0002735_abnormal_chemical_nociception2.15779449
20MP0006276_abnormal_autonomic_nervous2.12327389
21MP0003693_abnormal_embryo_hatching2.08168038
22MP0003718_maternal_effect2.07239623
23MP0001968_abnormal_touch/_nociception2.05329195
24MP0004381_abnormal_hair_follicle1.95972754
25MP0002736_abnormal_nociception_after1.94990583
26MP0002272_abnormal_nervous_system1.92780976
27MP0010094_abnormal_chromosome_stability1.91024258
28MP0001986_abnormal_taste_sensitivity1.88012857
29MP0003646_muscle_fatigue1.84522910
30MP0009745_abnormal_behavioral_response1.83774097
31MP0006036_abnormal_mitochondrial_physio1.83013342
32MP0009046_muscle_twitch1.81449856
33MP0005646_abnormal_pituitary_gland1.80379718
34MP0005423_abnormal_somatic_nervous1.79304818
35MP0005551_abnormal_eye_electrophysiolog1.77706898
36MP0009379_abnormal_foot_pigmentation1.76912708
37MP0000920_abnormal_myelination1.73100058
38MP0006292_abnormal_olfactory_placode1.71048640
39MP0008875_abnormal_xenobiotic_pharmacok1.70963531
40MP0008872_abnormal_physiological_respon1.69195451
41MP0002734_abnormal_mechanical_nocicepti1.69063735
42MP0002277_abnormal_respiratory_mucosa1.67014723
43MP0008260_abnormal_autophagy1.61396001
44MP0001440_abnormal_grooming_behavior1.58734410
45MP0002234_abnormal_pharynx_morphology1.58538083
46MP0000372_irregular_coat_pigmentation1.58277896
47MP0002064_seizures1.54885009
48MP0001963_abnormal_hearing_physiology1.54308152
49MP0002572_abnormal_emotion/affect_behav1.54008581
50MP0002160_abnormal_reproductive_system1.52991586
51MP0005379_endocrine/exocrine_gland_phen1.51998297
52MP0003786_premature_aging1.50581196
53MP0000026_abnormal_inner_ear1.50298817
54MP0002067_abnormal_sensory_capabilities1.50116645
55MP0005075_abnormal_melanosome_morpholog1.49513643
56MP0003186_abnormal_redox_activity1.49422081
57MP0005084_abnormal_gallbladder_morpholo1.49157503
58MP0002876_abnormal_thyroid_physiology1.47616898
59MP0010386_abnormal_urinary_bladder1.43779668
60MP0002638_abnormal_pupillary_reflex1.43490599
61MP0002163_abnormal_gland_morphology1.42960001
62MP0005389_reproductive_system_phenotype1.39571792
63MP0003635_abnormal_synaptic_transmissio1.39385753
64MP0001346_abnormal_lacrimal_gland1.39195298
65MP0001764_abnormal_homeostasis1.38957262
66MP0003011_delayed_dark_adaptation1.35764146
67MP0001984_abnormal_olfaction1.35103132
68MP0001501_abnormal_sleep_pattern1.34981421
69MP0000579_abnormal_nail_morphology1.32403761
70MP0002095_abnormal_skin_pigmentation1.30327228
71MP0006072_abnormal_retinal_apoptosis1.28841741
72MP0001970_abnormal_pain_threshold1.26898196
73MP0006035_abnormal_mitochondrial_morpho1.26326004
74MP0004270_analgesia1.26315056
75MP0001485_abnormal_pinna_reflex1.25261589
76MP0004484_altered_response_of1.24914039
77MP0008789_abnormal_olfactory_epithelium1.22770243
78MP0001502_abnormal_circadian_rhythm1.19880436
79MP0000778_abnormal_nervous_system1.18966916
80MP0004133_heterotaxia1.18156942
81MP0003787_abnormal_imprinting1.16312874
82MP0002557_abnormal_social/conspecific_i1.14775639
83MP0004957_abnormal_blastocyst_morpholog1.14002689
84MP0001919_abnormal_reproductive_system1.12952791
85MP0005332_abnormal_amino_acid1.12683560
86MP0002752_abnormal_somatic_nervous1.11655814
87MP0002210_abnormal_sex_determination1.11239188
88MP0005410_abnormal_fertilization1.11133789
89MP0009697_abnormal_copulation1.10709183
90MP0003950_abnormal_plasma_membrane1.10267671
91MP0002063_abnormal_learning/memory/cond1.10130353
92MP0004859_abnormal_synaptic_plasticity1.09766414
93MP0008004_abnormal_stomach_pH1.09488180
94MP0000427_abnormal_hair_cycle1.09277770
95MP0005253_abnormal_eye_physiology1.09228446
96MP0000383_abnormal_hair_follicle1.07184161
97MP0002184_abnormal_innervation1.06300022
98MP0001929_abnormal_gametogenesis1.05878270
99MP0005408_hypopigmentation1.05196195
100MP0004043_abnormal_pH_regulation1.05087211
101MP0000647_abnormal_sebaceous_gland1.03815496
102MP0001293_anophthalmia1.02579872
103MP0000015_abnormal_ear_pigmentation1.02390157
104MP0004924_abnormal_behavior1.01322226
105MP0005386_behavior/neurological_phenoty1.01322226
106MP0002653_abnormal_ependyma_morphology1.00324211
107MP0005174_abnormal_tail_pigmentation0.99397270
108MP0000762_abnormal_tongue_morphology0.98673194
109MP0003938_abnormal_ear_development0.97815762
110MP0002733_abnormal_thermal_nociception0.97368375
111MP0003698_abnormal_male_reproductive0.93389203
112MP0003283_abnormal_digestive_organ0.91643447
113MP0003111_abnormal_nucleus_morphology0.91138391
114MP0000653_abnormal_sex_gland0.89749705
115MP0002229_neurodegeneration0.88702797
116MP0003121_genomic_imprinting0.87563117
117MP0000049_abnormal_middle_ear0.87278227
118MP0003077_abnormal_cell_cycle0.87142997
119MP0001664_abnormal_digestion0.86375061
120MP0002822_catalepsy0.86293317
121MP0005636_abnormal_mineral_homeostasis0.84750613
122MP0001145_abnormal_male_reproductive0.84453446
123MP0002938_white_spotting0.84249821
124MP0004885_abnormal_endolymph0.84045609
125MP0003941_abnormal_skin_development0.83604888
126MP0001324_abnormal_eye_pigmentation0.83104106
127MP0002132_abnormal_respiratory_system0.82562907
128MP0000462_abnormal_digestive_system0.81856772
129MP0005085_abnormal_gallbladder_physiolo0.81282604
130MP0000631_abnormal_neuroendocrine_gland0.80907284
131MP0000569_abnormal_digit_pigmentation0.80427021
132MP0002882_abnormal_neuron_morphology0.79648343
133MP0002751_abnormal_autonomic_nervous0.79132433
134MP0003119_abnormal_digestive_system0.79048142
135MP0008932_abnormal_embryonic_tissue0.78978107
136MP0003137_abnormal_impulse_conducting0.78194070
137MP0002066_abnormal_motor_capabilities/c0.77342296
138MP0009250_abnormal_appendicular_skeleto0.76890921
139MP0004147_increased_porphyrin_level0.76492190
140MP0004215_abnormal_myocardial_fiber0.75904110
141MP0003195_calcinosis0.75751852
142MP0003879_abnormal_hair_cell0.75476772
143MP0002249_abnormal_larynx_morphology0.74934490
144MP0000681_abnormal_thyroid_gland0.74354970
145MP0008995_early_reproductive_senescence0.73321783
146MP0000538_abnormal_urinary_bladder0.72008993
147MP0003690_abnormal_glial_cell0.70662869
148MP0000678_abnormal_parathyroid_gland0.66779851
149MP0000955_abnormal_spinal_cord0.66235391
150MP0004145_abnormal_muscle_electrophysio0.65473158
151MP0003724_increased_susceptibility_to0.65442398
152MP0005195_abnormal_posterior_eye0.64400495
153MP0004782_abnormal_surfactant_physiolog0.64120487

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)3.71911080
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69907791
3Pancreatic cysts (HP:0001737)3.62142585
4Abnormal ciliary motility (HP:0012262)3.35968413
5Acute necrotizing encephalopathy (HP:0006965)3.32460367
6Abnormality of midbrain morphology (HP:0002418)3.31479360
7Molar tooth sign on MRI (HP:0002419)3.31479360
8Chromsome breakage (HP:0040012)3.23680108
9Congenital sensorineural hearing impairment (HP:0008527)3.18606925
10Focal motor seizures (HP:0011153)3.18554081
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.11584235
12Absent/shortened dynein arms (HP:0200106)3.11584235
13Febrile seizures (HP:0002373)3.11334771
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.08079981
153-Methylglutaconic aciduria (HP:0003535)2.94551144
16Hypothermia (HP:0002045)2.93073314
17Upper limb muscle weakness (HP:0003484)2.92019968
18Duplicated collecting system (HP:0000081)2.92018782
19Increased serum lactate (HP:0002151)2.91647226
20Progressive macrocephaly (HP:0004481)2.89906875
21Renal Fanconi syndrome (HP:0001994)2.83930820
22Mitochondrial inheritance (HP:0001427)2.83910122
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79410278
24Abnormality of alanine metabolism (HP:0010916)2.79410278
25Hyperalaninemia (HP:0003348)2.79410278
26Abnormality of the renal collecting system (HP:0004742)2.78761258
27Septo-optic dysplasia (HP:0100842)2.77140710
28Increased hepatocellular lipid droplets (HP:0006565)2.75001338
29Abnormal mitochondria in muscle tissue (HP:0008316)2.73259795
30Lactic acidosis (HP:0003128)2.73048140
31Abnormal respiratory motile cilium physiology (HP:0012261)2.68649813
32Type II lissencephaly (HP:0007260)2.67973115
33Decreased central vision (HP:0007663)2.66301372
34Patchy hypopigmentation of hair (HP:0011365)2.64865913
35Congenital stationary night blindness (HP:0007642)2.62901809
36Optic disc pallor (HP:0000543)2.60549387
37Abnormal respiratory epithelium morphology (HP:0012253)2.60069056
38Abnormal respiratory motile cilium morphology (HP:0005938)2.60069056
39Increased intramyocellular lipid droplets (HP:0012240)2.58964952
40Abnormal number of erythroid precursors (HP:0012131)2.56878147
41Congenital, generalized hypertrichosis (HP:0004540)2.55699434
42White forelock (HP:0002211)2.55034876
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54664125
44Exertional dyspnea (HP:0002875)2.54404214
45Methylmalonic aciduria (HP:0012120)2.51125072
46Prostate neoplasm (HP:0100787)2.49352392
47Acute encephalopathy (HP:0006846)2.48270048
48Medial flaring of the eyebrow (HP:0010747)2.47396807
49Retinal dysplasia (HP:0007973)2.45274429
50Conical tooth (HP:0000698)2.43959783
51Hyperglycinemia (HP:0002154)2.38851358
52Abnormality of cells of the erythroid lineage (HP:0012130)2.38231006
53Sclerocornea (HP:0000647)2.37281429
54Aplasia cutis congenita (HP:0001057)2.36100514
55Respiratory failure (HP:0002878)2.34744232
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32798378
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32798378
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31082888
59Microvesicular hepatic steatosis (HP:0001414)2.29729206
60Split foot (HP:0001839)2.28807561
61Absent septum pellucidum (HP:0001331)2.28053969
62Lethargy (HP:0001254)2.27460646
63Abnormality of the renal cortex (HP:0011035)2.25337831
64Abnormality of renal resorption (HP:0011038)2.24906043
65Increased CSF lactate (HP:0002490)2.21516786
66True hermaphroditism (HP:0010459)2.21255700
67Hypoplasia of the pons (HP:0012110)2.20222856
68Hepatocellular necrosis (HP:0001404)2.19444102
69Abnormality of the pons (HP:0007361)2.18906969
70Type I transferrin isoform profile (HP:0003642)2.17645132
71Congenital ichthyosiform erythroderma (HP:0007431)2.17024945
72Lipid accumulation in hepatocytes (HP:0006561)2.16087351
73Increased muscle lipid content (HP:0009058)2.15014676
74Abnormality of serum amino acid levels (HP:0003112)2.14134839
75Abnormality of the septum pellucidum (HP:0007375)2.14058146
76Duplication of thumb phalanx (HP:0009942)2.13101920
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12785065
78Optic nerve hypoplasia (HP:0000609)2.08933571
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.06912354
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06912354
81Abnormality of incisor morphology (HP:0011063)2.06449533
82Pendular nystagmus (HP:0012043)2.06022291
83Glycosuria (HP:0003076)2.05919397
84Abnormality of urine glucose concentration (HP:0011016)2.05919397
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04508651
86Renal cortical cysts (HP:0000803)2.04426404
87Abnormal protein glycosylation (HP:0012346)2.03693813
88Abnormal glycosylation (HP:0012345)2.03693813
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03693813
90Abnormal protein N-linked glycosylation (HP:0012347)2.03693813
91Abnormal drinking behavior (HP:0030082)2.02572176
92Polydipsia (HP:0001959)2.02572176
93Keratoconus (HP:0000563)2.02136768
94Increased corneal curvature (HP:0100692)2.02136768
95Colon cancer (HP:0003003)2.01429911
96Cerebellar dysplasia (HP:0007033)2.01244474
97Nasolacrimal duct obstruction (HP:0000579)2.00765293
98Gait imbalance (HP:0002141)2.00340265
99Leukodystrophy (HP:0002415)1.99509410
100Abolished electroretinogram (ERG) (HP:0000550)1.98964227
101Tetany (HP:0001281)1.97977805
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.97785156
103Metabolic alkalosis (HP:0200114)1.97630039
104CNS demyelination (HP:0007305)1.96200895
105Cystic liver disease (HP:0006706)1.93842265
106Congenital primary aphakia (HP:0007707)1.93465690
107Aplasia/hypoplasia of the uterus (HP:0008684)1.92710298
108Vaginal atresia (HP:0000148)1.92068445
109Male pseudohermaphroditism (HP:0000037)1.91983071
110Abnormal rod and cone electroretinograms (HP:0008323)1.91496519
111Nephrogenic diabetes insipidus (HP:0009806)1.91491075
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.91344100
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91296835
114Abnormality of the labia minora (HP:0012880)1.90846028
115Attenuation of retinal blood vessels (HP:0007843)1.90565630
116Reticulocytopenia (HP:0001896)1.89660444
117Adrenal hypoplasia (HP:0000835)1.89659205
118Genital tract atresia (HP:0001827)1.89498706
119Nephronophthisis (HP:0000090)1.88938749
120Methylmalonic acidemia (HP:0002912)1.88767168
121Abnormality of the ileum (HP:0001549)1.87906314
122Meckel diverticulum (HP:0002245)1.87710300
123Birth length less than 3rd percentile (HP:0003561)1.85553314
124Macrocytic anemia (HP:0001972)1.84985731
125Tubulointerstitial nephritis (HP:0001970)1.84707776
126Absent thumb (HP:0009777)1.84518876
127Large for gestational age (HP:0001520)1.84149971
128Aplasia/Hypoplasia of the fovea (HP:0008060)1.84090817
129Hypoplasia of the fovea (HP:0007750)1.84090817
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.83614547
131Severe muscular hypotonia (HP:0006829)1.83376705
132Hyperglycinuria (HP:0003108)1.82786726
133Furrowed tongue (HP:0000221)1.82712371
134Abnormality of serine family amino acid metabolism (HP:0010894)1.82598796
135Abnormality of glycine metabolism (HP:0010895)1.82598796
136Anencephaly (HP:0002323)1.82055497
137Progressive microcephaly (HP:0000253)1.81789562
138Hypomagnesemia (HP:0002917)1.80133058
139Sensory axonal neuropathy (HP:0003390)1.79506677
140Respiratory difficulties (HP:0002880)1.78197533
141Renal agenesis (HP:0000104)1.77798872
142Esotropia (HP:0000565)1.77749378
143Hepatic necrosis (HP:0002605)1.77188330
144Fetal akinesia sequence (HP:0001989)1.76482630
145Oligodactyly (hands) (HP:0001180)1.75544564
146Anomalous pulmonary venous return (HP:0010772)1.74544556
147Pancreatic fibrosis (HP:0100732)1.71753113
148Abnormality of the renal medulla (HP:0100957)1.70142060
149Broad-based gait (HP:0002136)1.69206320
150Nonprogressive disorder (HP:0003680)1.68646272
151Exercise intolerance (HP:0003546)1.68177558
152Absent speech (HP:0001344)1.66661970
153Onion bulb formation (HP:0003383)1.66571977
154Abnormality of the preputium (HP:0100587)1.63718387
155Aplasia/Hypoplasia of the lens (HP:0008063)1.63566516
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62751693
157Cerebral edema (HP:0002181)1.62044831
158Abnormality of the lacrimal duct (HP:0011481)1.60386566
159Postaxial foot polydactyly (HP:0001830)1.58655148
160Abnormality of secondary sexual hair (HP:0009888)1.58641442
161Abnormality of the axillary hair (HP:0100134)1.58641442
162Overfolded helix (HP:0000396)1.58572053
163Corneal dystrophy (HP:0001131)1.56602269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.03480883
2VRK23.31904338
3STK163.02282758
4TNIK2.99099398
5BUB12.77072437
6STK392.69920868
7MAP4K22.41788632
8MUSK2.25897950
9OXSR12.25550149
10EIF2AK21.98594558
11NEK11.97433455
12MAP2K71.93429927
13ACVR1B1.92555191
14PKN11.90659610
15ADRBK21.89558665
16GRK11.85218685
17MAPKAPK51.84851317
18BCKDK1.83495258
19BMPR1B1.79980221
20PRPF4B1.70927202
21BCR1.70747609
22WEE11.67412859
23TRIM281.61945820
24PBK1.60371471
25GRK71.54760190
26BRSK21.53972443
27MST41.50930263
28INSRR1.50154258
29NEK61.49503334
30BMPR21.49240110
31ZAK1.48801192
32PLK41.47716428
33PLK31.46896626
34IRAK31.44030444
35MAPK131.38273067
36TAF11.37458624
37OBSCN1.36750886
38EIF2AK11.35379149
39TXK1.35133344
40NTRK31.32001021
41CDC71.24688892
42STK38L1.24616175
43MKNK21.21248814
44PDK21.18331378
45PIK3CG1.12510172
46NME11.10648088
47TAOK31.09706101
48LIMK11.05732775
49TTK1.05531935
50CAMK2B1.04080202
51CDK31.01808539
52PLK11.01781950
53CAMK2A1.00504819
54CAMK2D1.00112821
55CCNB11.00057609
56YES10.97874679
57EPHA40.96763199
58PRKCE0.95438761
59TSSK60.95238799
60MKNK10.94773783
61TIE10.92188231
62IRAK10.91806591
63CDK190.88593995
64PIK3CA0.84303873
65CAMKK20.83363888
66WNK40.81635758
67BLK0.81080723
68SGK4940.80479297
69SGK2230.80479297
70VRK10.80248121
71TLK10.79883245
72SIK30.79689414
73MAP3K120.78370018
74CHEK20.77644282
75NEK20.77428437
76BRSK10.76962643
77FES0.76631844
78IRAK20.76142655
79ATR0.75979415
80IRAK40.75806004
81MARK10.75723552
82NTRK20.75456868
83CAMK2G0.75147875
84TEC0.72922468
85CLK10.72276126
86MAPK150.72156776
87DYRK20.71029878
88CSNK1G30.70851491
89AURKB0.68892000
90ERBB30.67804242
91TNK20.67546175
92PINK10.67522366
93CDK80.66791406
94PNCK0.66235653
95CSNK1A1L0.64266445
96TGFBR10.63581951
97MAP3K140.63364068
98GRK50.63236482
99RIPK40.62246148
100PAK30.61118388
101UHMK10.60677173
102SRPK10.60332514
103FGFR20.59987344
104RPS6KA50.57945809
105CSNK1G10.57872249
106TRPM70.56980545
107WNK10.56598936
108NUAK10.55690940
109CAMK10.55364074
110CSNK2A10.54932587
111PRKG10.54833851
112PRKACA0.54350555
113AURKA0.53217938
114EIF2AK30.52750315
115FGR0.51433225
116CSNK2A20.50482426
117PRKCI0.50262316
118WNK30.49617353
119MAP3K40.48985312
120IKBKE0.48954665
121PLK20.48552727
122NME20.47893186
123MAP2K60.47690494
124CSNK1A10.46932348
125PRKCQ0.46512211
126PRKCG0.46115787
127KDR0.45584209
128NLK0.44328082
129STK240.43901485
130DAPK10.42369202
131PHKG20.41866827
132PHKG10.41866827
133FRK0.40930428
134MYLK0.40331150
135ATM0.38725130
136LYN0.38374588
137EPHB10.38128815
138SGK10.37964863
139MARK30.37880093
140DYRK30.37735488
141CSNK1G20.37313368
142ADRBK10.37111109
143PASK0.35713524
144MINK10.34050734

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.68349972
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84451435
3Parkinsons disease_Homo sapiens_hsa050122.76900681
4Nicotine addiction_Homo sapiens_hsa050332.56382766
5Fatty acid elongation_Homo sapiens_hsa000622.49093786
6Alzheimers disease_Homo sapiens_hsa050102.41099493
7Steroid biosynthesis_Homo sapiens_hsa001002.32100138
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25454004
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15402729
10Phototransduction_Homo sapiens_hsa047442.11139497
11Huntingtons disease_Homo sapiens_hsa050162.10960766
12Mismatch repair_Homo sapiens_hsa034302.07365513
13Ether lipid metabolism_Homo sapiens_hsa005652.00031881
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98599105
15Protein export_Homo sapiens_hsa030601.95833760
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87423723
17DNA replication_Homo sapiens_hsa030301.86261859
18Sphingolipid metabolism_Homo sapiens_hsa006001.83992474
19Morphine addiction_Homo sapiens_hsa050321.79159647
20One carbon pool by folate_Homo sapiens_hsa006701.74106380
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70038550
22Serotonergic synapse_Homo sapiens_hsa047261.68579970
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65461006
24Pyrimidine metabolism_Homo sapiens_hsa002401.62267299
25Taste transduction_Homo sapiens_hsa047421.60334334
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59305939
27RNA degradation_Homo sapiens_hsa030181.56260571
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54253679
29Arachidonic acid metabolism_Homo sapiens_hsa005901.53850445
30Collecting duct acid secretion_Homo sapiens_hsa049661.53787865
31Linoleic acid metabolism_Homo sapiens_hsa005911.51615759
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48615193
33Glutamatergic synapse_Homo sapiens_hsa047241.47232483
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45692200
35Nucleotide excision repair_Homo sapiens_hsa034201.43261313
36Sulfur relay system_Homo sapiens_hsa041221.40077668
37Base excision repair_Homo sapiens_hsa034101.39962494
38Cardiac muscle contraction_Homo sapiens_hsa042601.38502368
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30470097
40Autoimmune thyroid disease_Homo sapiens_hsa053201.30386064
41Fanconi anemia pathway_Homo sapiens_hsa034601.29660887
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26714385
43Rheumatoid arthritis_Homo sapiens_hsa053231.25025938
44Nitrogen metabolism_Homo sapiens_hsa009101.22823205
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21661842
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21147479
47Histidine metabolism_Homo sapiens_hsa003401.18816758
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18215672
49Spliceosome_Homo sapiens_hsa030401.15733438
50Olfactory transduction_Homo sapiens_hsa047401.15466945
51RNA transport_Homo sapiens_hsa030131.13622412
52GABAergic synapse_Homo sapiens_hsa047271.11118238
53Peroxisome_Homo sapiens_hsa041461.10979644
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.10955571
55Calcium signaling pathway_Homo sapiens_hsa040201.09507068
56Selenocompound metabolism_Homo sapiens_hsa004501.08957681
57Ovarian steroidogenesis_Homo sapiens_hsa049131.08066881
58Basal transcription factors_Homo sapiens_hsa030221.07217342
59Tryptophan metabolism_Homo sapiens_hsa003801.06995043
60Non-homologous end-joining_Homo sapiens_hsa034501.06865187
61Folate biosynthesis_Homo sapiens_hsa007901.03794752
62Homologous recombination_Homo sapiens_hsa034401.03215025
63Vitamin B6 metabolism_Homo sapiens_hsa007501.01980379
64Circadian entrainment_Homo sapiens_hsa047130.99404661
65Ribosome_Homo sapiens_hsa030100.98478323
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98449241
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98394785
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.94626897
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91294836
70RNA polymerase_Homo sapiens_hsa030200.91135196
71Salivary secretion_Homo sapiens_hsa049700.89280697
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86925164
73Amphetamine addiction_Homo sapiens_hsa050310.86914905
74Cocaine addiction_Homo sapiens_hsa050300.86728285
75Vitamin digestion and absorption_Homo sapiens_hsa049770.86040309
76Caffeine metabolism_Homo sapiens_hsa002320.84821000
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.84510645
78Axon guidance_Homo sapiens_hsa043600.83488924
79Retinol metabolism_Homo sapiens_hsa008300.83208376
80Pyruvate metabolism_Homo sapiens_hsa006200.83101497
81Glutathione metabolism_Homo sapiens_hsa004800.81433961
82Long-term depression_Homo sapiens_hsa047300.81035127
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80331726
84Allograft rejection_Homo sapiens_hsa053300.79759335
85Synaptic vesicle cycle_Homo sapiens_hsa047210.78757145
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77421071
87Sulfur metabolism_Homo sapiens_hsa009200.76751845
88Chemical carcinogenesis_Homo sapiens_hsa052040.75780615
89Purine metabolism_Homo sapiens_hsa002300.72982204
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72477730
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.70894135
92Insulin secretion_Homo sapiens_hsa049110.69384400
93Asthma_Homo sapiens_hsa053100.69005607
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68863961
95Cholinergic synapse_Homo sapiens_hsa047250.68674026
96Arginine and proline metabolism_Homo sapiens_hsa003300.68549426
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68209497
98Regulation of autophagy_Homo sapiens_hsa041400.67045859
99Metabolic pathways_Homo sapiens_hsa011000.66249662
100Hematopoietic cell lineage_Homo sapiens_hsa046400.65494839
101Graft-versus-host disease_Homo sapiens_hsa053320.64365379
102Vibrio cholerae infection_Homo sapiens_hsa051100.62349973
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.61145014
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61131748
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60855132
106ABC transporters_Homo sapiens_hsa020100.59952617
107Mineral absorption_Homo sapiens_hsa049780.59513170
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57317895
109Other glycan degradation_Homo sapiens_hsa005110.56411784
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56132406
111Phagosome_Homo sapiens_hsa041450.54796582
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.54115776
113Proteasome_Homo sapiens_hsa030500.53554835
114Renin secretion_Homo sapiens_hsa049240.52081394
115Dopaminergic synapse_Homo sapiens_hsa047280.51328322
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50461785
117African trypanosomiasis_Homo sapiens_hsa051430.50136104
118Ras signaling pathway_Homo sapiens_hsa040140.50101537
119Pancreatic secretion_Homo sapiens_hsa049720.49233203
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.48523981
121beta-Alanine metabolism_Homo sapiens_hsa004100.47678216
122Propanoate metabolism_Homo sapiens_hsa006400.46406410
123cAMP signaling pathway_Homo sapiens_hsa040240.44952367
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44230007
125Cell cycle_Homo sapiens_hsa041100.43293309
126Primary immunodeficiency_Homo sapiens_hsa053400.42797270
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38939461
128Butanoate metabolism_Homo sapiens_hsa006500.38665102
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37238331
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35747227
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34336601
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.34312615
133Gastric acid secretion_Homo sapiens_hsa049710.34113023
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33902518
135Fatty acid degradation_Homo sapiens_hsa000710.33883442
136N-Glycan biosynthesis_Homo sapiens_hsa005100.33679499
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33519555
138Tyrosine metabolism_Homo sapiens_hsa003500.32811773
139Fat digestion and absorption_Homo sapiens_hsa049750.31767933
140Fatty acid metabolism_Homo sapiens_hsa012120.30829983
141p53 signaling pathway_Homo sapiens_hsa041150.27538367
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26976579
143Oocyte meiosis_Homo sapiens_hsa041140.24160404

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