MRPL49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.93448041
2Golgi transport vesicle coating (GO:0048200)4.93448041
3ribosomal small subunit assembly (GO:0000028)4.92166649
4nucleobase biosynthetic process (GO:0046112)4.80074406
5purine nucleobase biosynthetic process (GO:0009113)4.68388562
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67452412
7maturation of SSU-rRNA (GO:0030490)4.60911735
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.39013458
9protein maturation by protein folding (GO:0022417)4.38140798
10proline biosynthetic process (GO:0006561)4.38054406
11proteasome assembly (GO:0043248)4.33353996
12formation of translation preinitiation complex (GO:0001731)4.20938163
13DNA strand elongation involved in DNA replication (GO:0006271)4.20064823
14viral transcription (GO:0019083)4.18244032
15translational termination (GO:0006415)4.17587890
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16645825
17ATP synthesis coupled proton transport (GO:0015986)4.16645825
18ribosomal small subunit biogenesis (GO:0042274)4.09923326
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08510510
20spliceosomal snRNP assembly (GO:0000387)4.07186186
21DNA strand elongation (GO:0022616)4.04566756
22DNA replication initiation (GO:0006270)4.00368443
23telomere maintenance via semi-conservative replication (GO:0032201)3.99282037
24DNA deamination (GO:0045006)3.96767590
25viral mRNA export from host cell nucleus (GO:0046784)3.91814681
26spliceosomal complex assembly (GO:0000245)3.91624094
27ribosomal large subunit biogenesis (GO:0042273)3.89587156
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86997053
29translational elongation (GO:0006414)3.85364496
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83342950
31regulation of translational fidelity (GO:0006450)3.80956566
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80629106
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.80252686
34cullin deneddylation (GO:0010388)3.78281455
35DNA unwinding involved in DNA replication (GO:0006268)3.75715364
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.74597513
37negative regulation of ligase activity (GO:0051352)3.74597513
38establishment of viral latency (GO:0019043)3.72165124
39ribonucleoprotein complex biogenesis (GO:0022613)3.71624098
40translational initiation (GO:0006413)3.63933400
417-methylguanosine mRNA capping (GO:0006370)3.63767445
42GMP metabolic process (GO:0046037)3.63646330
43ribosome biogenesis (GO:0042254)3.59984067
44folic acid-containing compound biosynthetic process (GO:0009396)3.59717575
45termination of RNA polymerase III transcription (GO:0006386)3.59611974
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.59611974
47oxidative phosphorylation (GO:0006119)3.59505354
48telomere maintenance via recombination (GO:0000722)3.56531136
49DNA replication checkpoint (GO:0000076)3.55514121
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55255695
51rRNA modification (GO:0000154)3.54353215
52protein deneddylation (GO:0000338)3.52893853
537-methylguanosine RNA capping (GO:0009452)3.52818024
54RNA capping (GO:0036260)3.52818024
55ribosome assembly (GO:0042255)3.52757842
56base-excision repair, AP site formation (GO:0006285)3.51468838
57mitotic metaphase plate congression (GO:0007080)3.49217630
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47128832
59tRNA aminoacylation for protein translation (GO:0006418)3.45826208
60establishment of integrated proviral latency (GO:0075713)3.45410328
61folic acid metabolic process (GO:0046655)3.45352411
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44305854
63cotranslational protein targeting to membrane (GO:0006613)3.42989957
64peptidyl-arginine omega-N-methylation (GO:0035247)3.42976863
65amino acid activation (GO:0043038)3.42457673
66tRNA aminoacylation (GO:0043039)3.42457673
67rRNA processing (GO:0006364)3.41665935
68transcription-coupled nucleotide-excision repair (GO:0006283)3.40588879
69* translation (GO:0006412)3.40031301
70mitotic recombination (GO:0006312)3.39810800
71pseudouridine synthesis (GO:0001522)3.38280508
72cellular protein complex disassembly (GO:0043624)3.38032561
73protein targeting to ER (GO:0045047)3.37755141
74cellular component biogenesis (GO:0044085)3.37742893
75regulation of cellular amino acid metabolic process (GO:0006521)3.36724080
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33685602
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30596163
78CENP-A containing nucleosome assembly (GO:0034080)3.29928878
79viral life cycle (GO:0019058)3.26957074
80rRNA metabolic process (GO:0016072)3.26089563
81positive regulation of ligase activity (GO:0051351)3.25503043
82tRNA methylation (GO:0030488)3.25179477
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23225257
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23225257
85chromatin remodeling at centromere (GO:0031055)3.22617077
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20877342
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20877342
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20877342
89protein localization to endoplasmic reticulum (GO:0070972)3.20656553
90regulation of translational termination (GO:0006449)3.20382450
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19544587
92signal transduction involved in DNA damage checkpoint (GO:0072422)3.19544587
93histone arginine methylation (GO:0034969)3.19084981
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18537126
95establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18349565
96mitochondrial respiratory chain complex I assembly (GO:0032981)3.18242201
97NADH dehydrogenase complex assembly (GO:0010257)3.18242201
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18242201
99tricarboxylic acid cycle (GO:0006099)3.17214995
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.16621871
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.14590254
102protein complex biogenesis (GO:0070271)3.13320037
103telomere maintenance via telomere lengthening (GO:0010833)3.13232927
104pteridine-containing compound biosynthetic process (GO:0042559)3.12055880
105respiratory electron transport chain (GO:0022904)3.11233353
106mitochondrial respiratory chain complex assembly (GO:0033108)3.10716772
107regulation of mitochondrial translation (GO:0070129)3.10655848
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10259420
109regulation of ubiquitin-protein transferase activity (GO:0051438)3.07506563
110deoxyribonucleotide biosynthetic process (GO:0009263)3.06491621
111transcription elongation from RNA polymerase I promoter (GO:0006362)3.05651845
112guanosine-containing compound biosynthetic process (GO:1901070)3.05198310
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04238015
114electron transport chain (GO:0022900)3.03927865
115IMP biosynthetic process (GO:0006188)3.03665523
116termination of RNA polymerase I transcription (GO:0006363)3.03653880
117protein targeting to mitochondrion (GO:0006626)3.03236111
118rRNA methylation (GO:0031167)3.03092550
119nucleobase-containing small molecule interconversion (GO:0015949)3.02508654
120cell cycle G1/S phase transition (GO:0044843)3.02227378
121G1/S transition of mitotic cell cycle (GO:0000082)3.02227378
122protein complex disassembly (GO:0043241)3.00967772
123DNA damage response, detection of DNA damage (GO:0042769)3.00091521
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97708453
125GDP-mannose metabolic process (GO:0019673)2.97284808
126regulation of ligase activity (GO:0051340)2.96159197
127L-serine metabolic process (GO:0006563)2.93263348
128pentose-phosphate shunt (GO:0006098)2.91346031
129base-excision repair (GO:0006284)2.87245025
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.87106059
131mitotic chromosome condensation (GO:0007076)2.86629170
132pentose metabolic process (GO:0019321)2.85282954
133mitochondrial RNA metabolic process (GO:0000959)2.84911090
134NADPH regeneration (GO:0006740)2.84893582
135establishment of protein localization to mitochondrion (GO:0072655)2.82204739
136chaperone-mediated protein transport (GO:0072321)2.82004813
137pyrimidine nucleotide catabolic process (GO:0006244)2.79663460
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78426995
139activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.78014070
140NADH metabolic process (GO:0006734)2.77601486
141regulation of cellular amine metabolic process (GO:0033238)2.76458674
142proline metabolic process (GO:0006560)2.73353372
143pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72407199
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71972725
145deoxyribonucleotide catabolic process (GO:0009264)2.69261602
146protein localization to mitochondrion (GO:0070585)2.68127517
147nuclear envelope reassembly (GO:0031468)2.68003079
148mitotic nuclear envelope reassembly (GO:0007084)2.68003079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08936710
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49693343
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23204730
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07523794
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.69772996
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.66621476
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65535889
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.44787388
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23031876
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22057392
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14491293
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12693627
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06636957
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00595168
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97536595
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85588437
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75994111
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.68550524
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67656891
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59408078
21XRN2_22483619_ChIP-Seq_HELA_Human2.58827296
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54555787
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50411082
24VDR_23849224_ChIP-Seq_CD4+_Human2.40635204
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36474983
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35476465
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.34782991
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22484335
29FOXP3_21729870_ChIP-Seq_TREG_Human2.16164903
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14808052
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.14413845
32GABP_19822575_ChIP-Seq_HepG2_Human2.07806992
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99426315
34TTF2_22483619_ChIP-Seq_HELA_Human1.98340226
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.97628469
36* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95125208
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91536683
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89181214
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87958903
40AR_21909140_ChIP-Seq_LNCAP_Human1.86044860
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81811393
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80507525
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79512829
44ELK1_19687146_ChIP-ChIP_HELA_Human1.78632590
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72988198
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64060350
47ZNF263_19887448_ChIP-Seq_K562_Human1.63887410
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63130302
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62201021
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52904934
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52151984
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.51708241
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49004431
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47922917
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46063389
56CIITA_25753668_ChIP-Seq_RAJI_Human1.45502809
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44043123
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43509288
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43214803
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39225041
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34872074
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34024263
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30226102
64KDM5A_27292631_Chip-Seq_BREAST_Human1.26779327
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24252112
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22430401
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21788112
68MYC_18940864_ChIP-ChIP_HL60_Human1.20845012
69MYC_22102868_ChIP-Seq_BL_Human1.20793873
70* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20712711
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.19733848
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17488474
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16210356
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15958163
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15320956
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14908538
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13032629
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12833482
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.12830349
80TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09172422
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07532014
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06659832
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06521262
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05475158
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03275187
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02927162
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02868039
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.02584213
89* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02414175
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02086169
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01658928
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01355645
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01107952
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01077290
95* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00425732
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99462110
97* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98798842
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98560610
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97129722
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96898517
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96869090
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.96836811
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96651502
104* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96278259
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95421901
106* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95175271
107CHD1_26751641_Chip-Seq_LNCaP_Human0.95058514
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94270702
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94269981
110ATF3_27146783_Chip-Seq_COLON_Human0.92021666
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91987735
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90480590
113* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89668621
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88205839
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86418681
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.86414888
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.84119645
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83822310
119TFEB_21752829_ChIP-Seq_HELA_Human0.83779860
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83776184
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81569752
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79764560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.60045070
2MP0004957_abnormal_blastocyst_morpholog4.40967951
3MP0010094_abnormal_chromosome_stability3.74464541
4MP0003111_abnormal_nucleus_morphology3.51369981
5MP0003806_abnormal_nucleotide_metabolis3.39124791
6MP0003077_abnormal_cell_cycle3.28896499
7MP0003123_paternal_imprinting3.23094183
8MP0008058_abnormal_DNA_repair3.20652829
9MP0003011_delayed_dark_adaptation2.87637379
10MP0008057_abnormal_DNA_replication2.84178255
11MP0010030_abnormal_orbit_morphology2.82579556
12MP0010234_abnormal_vibrissa_follicle2.80726489
13MP0005451_abnormal_body_composition2.70059656
14MP0008932_abnormal_embryonic_tissue2.59553355
15MP0006035_abnormal_mitochondrial_morpho2.57491507
16MP0006036_abnormal_mitochondrial_physio2.55411220
17MP0001986_abnormal_taste_sensitivity2.46109296
18MP0008007_abnormal_cellular_replicative2.25564098
19MP0005551_abnormal_eye_electrophysiolog2.24896881
20MP0003718_maternal_effect2.21216072
21MP0005501_abnormal_skin_physiology2.12381290
22MP0004264_abnormal_extraembryonic_tissu2.10528334
23MP0009379_abnormal_foot_pigmentation2.00250892
24MP0001730_embryonic_growth_arrest1.99912518
25MP0001346_abnormal_lacrimal_gland1.99496773
26MP0002796_impaired_skin_barrier1.90172725
27MP0003786_premature_aging1.76755989
28MP0006072_abnormal_retinal_apoptosis1.75397853
29MP0001529_abnormal_vocalization1.73428404
30MP0001661_extended_life_span1.71957105
31MP0005253_abnormal_eye_physiology1.71277436
32MP0003315_abnormal_perineum_morphology1.62984378
33MP0003186_abnormal_redox_activity1.60282234
34MP0000350_abnormal_cell_proliferation1.59950008
35MP0000372_irregular_coat_pigmentation1.58280498
36MP0002877_abnormal_melanocyte_morpholog1.57920383
37MP0005423_abnormal_somatic_nervous1.56339597
38MP0009697_abnormal_copulation1.50824594
39MP0001697_abnormal_embryo_size1.49502644
40MP0001764_abnormal_homeostasis1.46545890
41MP0003121_genomic_imprinting1.43910940
42MP0003221_abnormal_cardiomyocyte_apopto1.42624992
43MP0005380_embryogenesis_phenotype1.42479739
44MP0001672_abnormal_embryogenesis/_devel1.42479739
45MP0004185_abnormal_adipocyte_glucose1.41070238
46MP0005266_abnormal_metabolism1.40731106
47MP0003567_abnormal_fetal_cardiomyocyte1.38133797
48MP0002080_prenatal_lethality1.37673763
49MP0004147_increased_porphyrin_level1.37103680
50MP0005408_hypopigmentation1.35993635
51MP0003984_embryonic_growth_retardation1.33721110
52MP0002088_abnormal_embryonic_growth/wei1.32047958
53MP0008789_abnormal_olfactory_epithelium1.31959662
54MP0008877_abnormal_DNA_methylation1.31678953
55MP0000566_synostosis1.31551333
56MP0009333_abnormal_splenocyte_physiolog1.30954926
57MP0000490_abnormal_crypts_of1.29333236
58MP0006292_abnormal_olfactory_placode1.26034547
59MP0004782_abnormal_surfactant_physiolog1.23950080
60MP0009840_abnormal_foam_cell1.23529670
61MP0002132_abnormal_respiratory_system1.23434102
62MP0000537_abnormal_urethra_morphology1.19621766
63MP0000358_abnormal_cell_content/1.18718145
64MP0005083_abnormal_biliary_tract1.18647890
65MP0002160_abnormal_reproductive_system1.18194318
66MP0001881_abnormal_mammary_gland1.18144842
67MP0003646_muscle_fatigue1.14014554
68MP0002085_abnormal_embryonic_tissue1.11991159
69MP0002127_abnormal_cardiovascular_syste1.08737301
70MP0003119_abnormal_digestive_system1.07168346
71MP0005379_endocrine/exocrine_gland_phen1.07075655
72MP0004084_abnormal_cardiac_muscle1.06700742
73MP0002638_abnormal_pupillary_reflex1.06171985
74MP0000313_abnormal_cell_death1.03365123
75MP0001727_abnormal_embryo_implantation1.01890458
76MP0008260_abnormal_autophagy1.00849077
77MP0002098_abnormal_vibrissa_morphology1.00761299
78MP0005391_vision/eye_phenotype1.00701705
79MP0003122_maternal_imprinting0.99723648
80MP0004133_heterotaxia0.98488000
81MP0003191_abnormal_cellular_cholesterol0.98348367
82MP0005389_reproductive_system_phenotype0.97021265
83MP0002332_abnormal_exercise_endurance0.96920920
84MP0002084_abnormal_developmental_patter0.96241688
85MP0005075_abnormal_melanosome_morpholog0.94714009
86MP0005499_abnormal_olfactory_system0.94638209
87MP0005394_taste/olfaction_phenotype0.94638209
88MP0004233_abnormal_muscle_weight0.93501937
89MP0000627_abnormal_mammary_gland0.91493506
90MP0004215_abnormal_myocardial_fiber0.91459097
91MP0002396_abnormal_hematopoietic_system0.91030875
92MP0002254_reproductive_system_inflammat0.90420435
93MP0009053_abnormal_anal_canal0.89652394
94MP0005332_abnormal_amino_acid0.89257991
95MP0001873_stomach_inflammation0.88748663
96MP0001905_abnormal_dopamine_level0.88603140
97MP0008995_early_reproductive_senescence0.87221126
98MP0000750_abnormal_muscle_regeneration0.86520009
99MP0005195_abnormal_posterior_eye0.86435580
100MP0002086_abnormal_extraembryonic_tissu0.86281945
101MP0008875_abnormal_xenobiotic_pharmacok0.86237705
102MP0009780_abnormal_chondrocyte_physiolo0.85775865
103MP0010771_integument_phenotype0.84745390
104MP0001216_abnormal_epidermal_layer0.84125513
105MP0005376_homeostasis/metabolism_phenot0.83568697
106MP0002060_abnormal_skin_morphology0.83201440
107MP0010352_gastrointestinal_tract_polyps0.82785948
108MP0002653_abnormal_ependyma_morphology0.82507455
109MP0000613_abnormal_salivary_gland0.81488988
110MP0002210_abnormal_sex_determination0.80936339
111MP0002837_dystrophic_cardiac_calcinosis0.80734048
112MP0005257_abnormal_intraocular_pressure0.79108303
113MP0001293_anophthalmia0.78648766
114MP0005384_cellular_phenotype0.77814694
115MP0001145_abnormal_male_reproductive0.77411345
116MP0004142_abnormal_muscle_tone0.77123634
117MP0002019_abnormal_tumor_incidence0.76904048
118MP0000377_abnormal_hair_follicle0.76629385
119MP0003941_abnormal_skin_development0.76252091
120MP0006276_abnormal_autonomic_nervous0.74772770
121MP0002102_abnormal_ear_morphology0.74441178
122MP0009672_abnormal_birth_weight0.73514370
123MP0005636_abnormal_mineral_homeostasis0.71213146
124MP0000647_abnormal_sebaceous_gland0.71128410
125MP0005330_cardiomyopathy0.70458095
126MP0005085_abnormal_gallbladder_physiolo0.70052002
127MP0002269_muscular_atrophy0.69439045
128MP0004197_abnormal_fetal_growth/weight/0.69317581
129MP0001348_abnormal_lacrimal_gland0.69273499
130MP0001919_abnormal_reproductive_system0.68449337
131MP0000609_abnormal_liver_physiology0.68071093
132MP0002111_abnormal_tail_morphology0.67734151
133MP0000749_muscle_degeneration0.67277059
134MP0001286_abnormal_eye_development0.66930990
135MP0002938_white_spotting0.65543699
136MP0003942_abnormal_urinary_system0.63286371
137MP0000653_abnormal_sex_gland0.63185450
138MP0003566_abnormal_cell_adhesion0.62782477
139MP0002751_abnormal_autonomic_nervous0.62540376
140MP0001849_ear_inflammation0.61045643
141MP0005367_renal/urinary_system_phenotyp0.60695041
142MP0000516_abnormal_urinary_system0.60695041
143MP0003936_abnormal_reproductive_system0.60451183
144MP0002163_abnormal_gland_morphology0.59233512
145MP0003656_abnormal_erythrocyte_physiolo0.58684052
146MP0003890_abnormal_embryonic-extraembry0.58554819
147MP0008872_abnormal_physiological_respon0.56484917

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.51637220
2Acute necrotizing encephalopathy (HP:0006965)4.73092251
3Abnormal mitochondria in muscle tissue (HP:0008316)4.70400012
4Abnormality of cells of the erythroid lineage (HP:0012130)4.45244352
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.36694969
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.36694969
7Abnormal number of erythroid precursors (HP:0012131)4.24650787
8Mitochondrial inheritance (HP:0001427)4.21353460
9Increased CSF lactate (HP:0002490)4.10510422
10Hepatocellular necrosis (HP:0001404)4.10040607
11Birth length less than 3rd percentile (HP:0003561)4.06293131
12Acute encephalopathy (HP:0006846)4.02463929
13Increased serum pyruvate (HP:0003542)3.79400255
14Abnormality of glycolysis (HP:0004366)3.79400255
15Progressive macrocephaly (HP:0004481)3.77842133
16Hepatic necrosis (HP:0002605)3.77209740
17Increased serum lactate (HP:0002151)3.68179611
18Reticulocytopenia (HP:0001896)3.62126809
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.41356008
20Testicular atrophy (HP:0000029)3.38666005
21Breast hypoplasia (HP:0003187)3.36649526
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.33658446
23Abnormal gallbladder physiology (HP:0012438)3.32061484
24Cholecystitis (HP:0001082)3.32061484
25Lactic acidosis (HP:0003128)3.30820615
26Increased hepatocellular lipid droplets (HP:0006565)3.27135718
27Cerebral edema (HP:0002181)3.22148170
28Macrocytic anemia (HP:0001972)3.15996533
29Lipid accumulation in hepatocytes (HP:0006561)3.12979022
30Exercise intolerance (HP:0003546)3.08314947
31Ragged-red muscle fibers (HP:0003200)3.07107518
32Increased intramyocellular lipid droplets (HP:0012240)3.01371577
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91263236
34Oral leukoplakia (HP:0002745)2.88044672
35Cerebral hypomyelination (HP:0006808)2.86759378
36Type I transferrin isoform profile (HP:0003642)2.79919700
37Optic disc pallor (HP:0000543)2.78229367
38Squamous cell carcinoma (HP:0002860)2.75651255
39Multiple enchondromatosis (HP:0005701)2.75446827
40Respiratory failure (HP:0002878)2.71418238
41Increased muscle lipid content (HP:0009058)2.69657289
42Abnormality of the distal phalanges of the toes (HP:0010182)2.69302148
43Hypokinesia (HP:0002375)2.63869983
44Premature ovarian failure (HP:0008209)2.63759737
45Pallor (HP:0000980)2.60790947
463-Methylglutaconic aciduria (HP:0003535)2.59648431
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58492332
48Abnormality of alanine metabolism (HP:0010916)2.58492332
49Hyperalaninemia (HP:0003348)2.58492332
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57960129
51Abnormal protein N-linked glycosylation (HP:0012347)2.57960129
52Abnormal protein glycosylation (HP:0012346)2.57960129
53Abnormal glycosylation (HP:0012345)2.57960129
54Pendular nystagmus (HP:0012043)2.53351271
55Respiratory difficulties (HP:0002880)2.53264620
56Abnormality of the umbilical cord (HP:0010881)2.51638833
57Septate vagina (HP:0001153)2.50938081
58Bony spicule pigmentary retinopathy (HP:0007737)2.50194341
59Abnormal rod and cone electroretinograms (HP:0008323)2.49982778
60Sparse eyelashes (HP:0000653)2.48418478
61Patellar aplasia (HP:0006443)2.47168532
62Entropion (HP:0000621)2.46939855
63Renal Fanconi syndrome (HP:0001994)2.45977300
64CNS demyelination (HP:0007305)2.45151803
65Cutaneous melanoma (HP:0012056)2.39820925
66Aplasia/Hypoplasia of the patella (HP:0006498)2.37597599
67Microretrognathia (HP:0000308)2.36359437
68Lethargy (HP:0001254)2.35784949
69Emotional lability (HP:0000712)2.34673676
70Leukodystrophy (HP:0002415)2.33653085
71Pigmentary retinal degeneration (HP:0001146)2.33294806
72Microvesicular hepatic steatosis (HP:0001414)2.28795105
73Progressive muscle weakness (HP:0003323)2.28322583
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.27660892
75Hyperglycinemia (HP:0002154)2.24463573
76Abnormal trabecular bone morphology (HP:0100671)2.24438204
77Pancytopenia (HP:0001876)2.19826233
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19810211
79Attenuation of retinal blood vessels (HP:0007843)2.18666779
80Abnormality of the labia minora (HP:0012880)2.16101486
81Megaloblastic anemia (HP:0001889)2.11971919
82Prominent metopic ridge (HP:0005487)2.09933383
83Unsteady gait (HP:0002317)2.07266598
84Carpal bone hypoplasia (HP:0001498)2.06920287
85Reduced antithrombin III activity (HP:0001976)2.06601065
86Abnormal lung lobation (HP:0002101)2.06238468
87Abnormality of the anterior horn cell (HP:0006802)2.03295438
88Degeneration of anterior horn cells (HP:0002398)2.03295438
89Abnormalities of placenta or umbilical cord (HP:0001194)2.02849559
90Aplastic anemia (HP:0001915)2.01769776
91Rough bone trabeculation (HP:0100670)2.01229369
92CNS hypomyelination (HP:0003429)2.00663477
93Abnormality of serum amino acid levels (HP:0003112)1.99814413
94Neoplasm of the adrenal gland (HP:0100631)1.98608200
95Secondary amenorrhea (HP:0000869)1.98059383
96Vertebral compression fractures (HP:0002953)1.96419296
97Absent radius (HP:0003974)1.95839237
98Progressive external ophthalmoplegia (HP:0000590)1.93595712
99Colon cancer (HP:0003003)1.93009955
100Postnatal microcephaly (HP:0005484)1.91499389
101Death in infancy (HP:0001522)1.90956686
102Abnormality of pyrimidine metabolism (HP:0004353)1.90642531
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89947402
104Congenital ichthyosiform erythroderma (HP:0007431)1.89566204
105Short nail (HP:0001799)1.88438758
106Hyperglycinuria (HP:0003108)1.87010561
107Progressive hearing impairment (HP:0001730)1.86646546
108Hyperammonemia (HP:0001987)1.85792012
109Aplasia involving forearm bones (HP:0009822)1.85721345
110Absent forearm bone (HP:0003953)1.85721345
111Chorioretinal atrophy (HP:0000533)1.85446842
112Cholelithiasis (HP:0001081)1.85436738
113Pili torti (HP:0003777)1.83744221
114Abnormal umbilical cord blood vessels (HP:0011403)1.83278800
115Single umbilical artery (HP:0001195)1.83278800
116Abnormality of the fetal cardiovascular system (HP:0010948)1.83278800
117Concave nail (HP:0001598)1.83266749
118Exertional dyspnea (HP:0002875)1.82835076
119Fasciculations (HP:0002380)1.82635921
120Seborrheic dermatitis (HP:0001051)1.81214835
121Abnormality of glycine metabolism (HP:0010895)1.79924403
122Abnormality of serine family amino acid metabolism (HP:0010894)1.79924403
123Abnormality of the ileum (HP:0001549)1.79601091
124Hypergonadotropic hypogonadism (HP:0000815)1.79477104
125Delusions (HP:0000746)1.79240207
126Trismus (HP:0000211)1.79047945
127Sparse lateral eyebrow (HP:0005338)1.78229573
128Abnormal gallbladder morphology (HP:0012437)1.77741293
129Female pseudohermaphroditism (HP:0010458)1.77626444
130Shoulder girdle muscle weakness (HP:0003547)1.77195493
131Hyperthyroidism (HP:0000836)1.77145118
132Meckel diverticulum (HP:0002245)1.76478618
133Palpitations (HP:0001962)1.76171166
134Abnormality of the gallbladder (HP:0005264)1.75812419
135Upper limb muscle weakness (HP:0003484)1.75786250
136Partial duplication of thumb phalanx (HP:0009944)1.75529939
137Brittle hair (HP:0002299)1.75528620
138Horseshoe kidney (HP:0000085)1.73992890
139Hypertensive crisis (HP:0100735)1.72155732
140Sensory axonal neuropathy (HP:0003390)1.71540334
141Abnormality of the preputium (HP:0100587)1.70563060
142Hypobetalipoproteinemia (HP:0003563)1.70184142
143Cellular immunodeficiency (HP:0005374)1.68777583
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68383739
145Absent thumb (HP:0009777)1.67982027
146Rhabdomyolysis (HP:0003201)1.66985366
147Triphalangeal thumb (HP:0001199)1.66041134
148Partial duplication of the phalanx of hand (HP:0009999)1.64269987
149Gliosis (HP:0002171)1.64180896
150Abnormal number of incisors (HP:0011064)1.63733635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.71108947
2WEE14.10636571
3VRK24.00392130
4NEK13.58156899
5STK163.41972576
6EIF2AK13.01700267
7CCNB12.98665925
8CDC72.77031039
9TSSK62.57645994
10NME22.50725330
11SMG12.35277894
12SRPK12.25146745
13PBK2.19196102
14TLK12.18528790
15BCKDK2.13926113
16NEK22.03937746
17BRSK21.98769140
18PLK41.90334289
19VRK11.85400268
20SIK31.78465756
21PLK11.78329995
22NME11.77649204
23IRAK31.77193130
24SIK11.71117358
25TTK1.69750279
26ACVR1B1.67697869
27TRIB31.62730464
28PASK1.55428363
29EIF2AK31.54518083
30PLK31.53579181
31RPS6KB21.49017569
32TESK21.46678000
33BRSK11.45093016
34ERN11.43633451
35MST1R1.41946429
36TGFBR11.40062326
37MAPKAPK31.39491185
38STK101.36770934
39ICK1.36364690
40AURKB1.36156710
41TAF11.35344099
42CDK71.33300707
43DYRK31.33283987
44AURKA1.32450483
45PDK31.31048769
46PDK41.31048769
47CDK81.27022948
48TRIM281.26760702
49LRRK21.22395007
50MKNK11.15984027
51ZAK1.07939508
52BRAF1.07200986
53SCYL21.03703520
54PIM21.03346708
55PDK21.03301776
56CHEK21.02308162
57MYLK1.01771233
58RPS6KA40.99305266
59ATR0.97717849
60MKNK20.95431731
61MAP3K120.93469338
62CDK40.90756434
63EPHA20.89006742
64PNCK0.88149405
65PAK40.86655386
66STK38L0.86168719
67AKT30.83395444
68EEF2K0.80629217
69CSNK2A10.76831774
70MAP3K80.76113805
71TAOK20.76026287
72PRKCI0.75798342
73LMTK20.74998165
74MAP2K20.74833220
75FLT30.74521798
76ARAF0.73224946
77DYRK20.73172226
78CSNK2A20.70898183
79KDR0.68154123
80GRK10.65872821
81CDK190.64149612
82ALK0.63485899
83TESK10.62740563
84CHEK10.62651839
85CSNK1G30.61523686
86DAPK10.59641479
87ERBB40.57513302
88CLK10.56777098
89PKN20.55451367
90ILK0.55171538
91RPS6KA50.54357262
92GRK60.54055865
93LIMK10.53929158
94STK40.52717477
95MAP3K110.49050346
96OBSCN0.46942791
97CDK20.46529584
98WNK40.44737361
99AKT20.44469287
100PAK10.43555584
101DAPK30.42082164
102MAPK110.41998676
103LATS20.39438473
104NUAK10.39366420
105EIF2AK20.37289857
106MST40.35683607
107CDK90.35600992
108CDK10.34915109
109ATM0.34390922
110ADRBK10.33957140
111PTK20.32852184
112PLK20.32577440
113PTK60.32441995
114CDK120.32430332
115ABL20.31839584
116CAMK2G0.29479827
117NEK90.28944796
118FGFR10.26885086
119PINK10.26875260
120CSNK1A1L0.26863080
121CSNK1G10.26267422
122BMX0.25761141
123PRKCG0.25521772
124MET0.24816613
125MUSK0.24710387
126RPS6KB10.24703129
127PIM10.24630672
128MTOR0.24261292
129YES10.23769388
130MAPKAPK20.23266269
131CSNK1E0.22742447
132RAF10.21096896
133WNK30.20231350
134CDK140.19393461
135CDK180.18976832
136CDK11A0.18061775
137CASK0.17696452

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98158089
2DNA replication_Homo sapiens_hsa030303.98082086
3Ribosome_Homo sapiens_hsa030103.93842194
4RNA polymerase_Homo sapiens_hsa030203.38319697
5Mismatch repair_Homo sapiens_hsa034303.17510451
6Phototransduction_Homo sapiens_hsa047443.09217927
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86500390
8Oxidative phosphorylation_Homo sapiens_hsa001902.77859703
9Spliceosome_Homo sapiens_hsa030402.74138391
10Pyrimidine metabolism_Homo sapiens_hsa002402.60624996
11Parkinsons disease_Homo sapiens_hsa050122.60441098
12Base excision repair_Homo sapiens_hsa034102.60421718
13Nucleotide excision repair_Homo sapiens_hsa034202.44727383
14RNA transport_Homo sapiens_hsa030132.43083123
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29098262
16Homologous recombination_Homo sapiens_hsa034402.19549631
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16775349
18Huntingtons disease_Homo sapiens_hsa050162.02631191
19One carbon pool by folate_Homo sapiens_hsa006701.89610293
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82798257
21Steroid biosynthesis_Homo sapiens_hsa001001.82032996
22Cell cycle_Homo sapiens_hsa041101.79227339
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54964121
24Biosynthesis of amino acids_Homo sapiens_hsa012301.53741452
25Basal transcription factors_Homo sapiens_hsa030221.53060620
26Alzheimers disease_Homo sapiens_hsa050101.52601508
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.48372071
28Purine metabolism_Homo sapiens_hsa002301.47567034
29Carbon metabolism_Homo sapiens_hsa012001.46160769
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.41631993
31RNA degradation_Homo sapiens_hsa030181.39234175
32Vitamin B6 metabolism_Homo sapiens_hsa007501.35745053
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33005098
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32146954
35Pyruvate metabolism_Homo sapiens_hsa006201.29644600
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27235987
37Fanconi anemia pathway_Homo sapiens_hsa034601.23341563
38Folate biosynthesis_Homo sapiens_hsa007901.22610476
39Non-homologous end-joining_Homo sapiens_hsa034501.19933255
40N-Glycan biosynthesis_Homo sapiens_hsa005101.17707485
41Sulfur metabolism_Homo sapiens_hsa009201.12319068
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05865361
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03151250
44Protein export_Homo sapiens_hsa030601.00032915
45mRNA surveillance pathway_Homo sapiens_hsa030150.97928472
46Pentose phosphate pathway_Homo sapiens_hsa000300.96243995
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.92533151
48Cardiac muscle contraction_Homo sapiens_hsa042600.92300271
49Propanoate metabolism_Homo sapiens_hsa006400.90153143
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90097400
51Glutathione metabolism_Homo sapiens_hsa004800.88550511
52Sulfur relay system_Homo sapiens_hsa041220.88389967
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83842806
54Selenocompound metabolism_Homo sapiens_hsa004500.81946059
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80844447
56Fructose and mannose metabolism_Homo sapiens_hsa000510.80771741
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77212639
58Oocyte meiosis_Homo sapiens_hsa041140.71893298
59Metabolic pathways_Homo sapiens_hsa011000.71671425
60Systemic lupus erythematosus_Homo sapiens_hsa053220.70789578
61Epstein-Barr virus infection_Homo sapiens_hsa051690.69392177
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63549555
63Phenylalanine metabolism_Homo sapiens_hsa003600.61561152
64p53 signaling pathway_Homo sapiens_hsa041150.60162576
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57998617
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55201353
67Galactose metabolism_Homo sapiens_hsa000520.51214397
68Peroxisome_Homo sapiens_hsa041460.51143425
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49414344
70Tyrosine metabolism_Homo sapiens_hsa003500.48011200
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.47500105
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46480829
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46266221
74Collecting duct acid secretion_Homo sapiens_hsa049660.46182612
75Arginine and proline metabolism_Homo sapiens_hsa003300.45242576
76Retinol metabolism_Homo sapiens_hsa008300.41487426
77Bladder cancer_Homo sapiens_hsa052190.37620080
78Fatty acid degradation_Homo sapiens_hsa000710.37490892
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34889363
80Fatty acid elongation_Homo sapiens_hsa000620.34271662
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32737121
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32131715
83Primary immunodeficiency_Homo sapiens_hsa053400.31728628
84Butanoate metabolism_Homo sapiens_hsa006500.30241454
85Alcoholism_Homo sapiens_hsa050340.29633630
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28381858
87Apoptosis_Homo sapiens_hsa042100.27886350
88beta-Alanine metabolism_Homo sapiens_hsa004100.26841130
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25170423
90Shigellosis_Homo sapiens_hsa051310.24968467
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23419747
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22387190
93Vibrio cholerae infection_Homo sapiens_hsa051100.22340491
94Chemical carcinogenesis_Homo sapiens_hsa052040.22286571
95Sphingolipid metabolism_Homo sapiens_hsa006000.19138048
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18824869
97Thyroid cancer_Homo sapiens_hsa052160.18538423
98Synaptic vesicle cycle_Homo sapiens_hsa047210.18252407
99Fatty acid biosynthesis_Homo sapiens_hsa000610.17925622
100Viral carcinogenesis_Homo sapiens_hsa052030.17879371
101Arginine biosynthesis_Homo sapiens_hsa002200.17601362
102Lysine degradation_Homo sapiens_hsa003100.15031423
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14439055
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13510480
105Fatty acid metabolism_Homo sapiens_hsa012120.13371020
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.12013937
107HTLV-I infection_Homo sapiens_hsa051660.11994166
108Regulation of autophagy_Homo sapiens_hsa041400.10821447
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10140676
110Tryptophan metabolism_Homo sapiens_hsa003800.09993371
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09806297
112Caffeine metabolism_Homo sapiens_hsa002320.09496141
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.09411169
114Herpes simplex infection_Homo sapiens_hsa051680.08616823
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07394326
116Arachidonic acid metabolism_Homo sapiens_hsa005900.05530946

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