MRPL50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.75245034
2ATP synthesis coupled proton transport (GO:0015986)5.29288889
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.29288889
4tricarboxylic acid cycle (GO:0006099)4.44835847
5oxidative phosphorylation (GO:0006119)4.42622105
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34607058
7respiratory electron transport chain (GO:0022904)4.28120514
8chromatin remodeling at centromere (GO:0031055)4.22914292
9cullin deneddylation (GO:0010388)4.18291498
10purine nucleobase biosynthetic process (GO:0009113)4.16888714
11CENP-A containing nucleosome assembly (GO:0034080)4.16699371
12electron transport chain (GO:0022900)4.15683635
13establishment of integrated proviral latency (GO:0075713)4.14622147
14lysine metabolic process (GO:0006553)4.10256719
15lysine catabolic process (GO:0006554)4.10256719
16nucleobase biosynthetic process (GO:0046112)4.02039146
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.01470599
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.01470599
19NADH dehydrogenase complex assembly (GO:0010257)4.01470599
20rRNA modification (GO:0000154)3.88791155
21chaperone-mediated protein transport (GO:0072321)3.87630443
22L-phenylalanine metabolic process (GO:0006558)3.87130321
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.87130321
24respiratory chain complex IV assembly (GO:0008535)3.86372244
25regulation of mitotic spindle checkpoint (GO:1903504)3.86040361
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.86040361
27proteasome assembly (GO:0043248)3.84945285
28termination of RNA polymerase III transcription (GO:0006386)3.84563209
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.84563209
30protein deneddylation (GO:0000338)3.84346337
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83338885
32L-phenylalanine catabolic process (GO:0006559)3.83338885
33ribosome assembly (GO:0042255)3.82644765
34glyoxylate metabolic process (GO:0046487)3.82411499
35oxaloacetate metabolic process (GO:0006107)3.79943047
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75507722
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.74442490
38NADH metabolic process (GO:0006734)3.73436894
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72868535
40succinate metabolic process (GO:0006105)3.71211518
41protein neddylation (GO:0045116)3.71090236
42amino acid salvage (GO:0043102)3.70780544
43L-methionine salvage (GO:0071267)3.70780544
44L-methionine biosynthetic process (GO:0071265)3.70780544
45aldehyde catabolic process (GO:0046185)3.67745190
46DNA double-strand break processing (GO:0000729)3.65168187
47serine family amino acid biosynthetic process (GO:0009070)3.63086121
48cellular ketone body metabolic process (GO:0046950)3.61915389
49histone exchange (GO:0043486)3.60023307
50protein complex biogenesis (GO:0070271)3.59866402
51cytochrome complex assembly (GO:0017004)3.49830071
52mitochondrial respiratory chain complex assembly (GO:0033108)3.48315767
53branched-chain amino acid catabolic process (GO:0009083)3.48291527
54glycine metabolic process (GO:0006544)3.46778872
55rRNA methylation (GO:0031167)3.46490588
56maturation of 5.8S rRNA (GO:0000460)3.44207853
57DNA damage response, detection of DNA damage (GO:0042769)3.36541499
58DNA replication checkpoint (GO:0000076)3.34570417
59regulation of cellular amino acid metabolic process (GO:0006521)3.34009849
60water-soluble vitamin biosynthetic process (GO:0042364)3.33712292
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31883221
62aromatic amino acid family catabolic process (GO:0009074)3.31253980
63ribosomal large subunit biogenesis (GO:0042273)3.28543494
64aspartate family amino acid catabolic process (GO:0009068)3.28176241
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26788140
66spliceosomal snRNP assembly (GO:0000387)3.26143705
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.25499236
68serine family amino acid metabolic process (GO:0009069)3.22362177
69mitotic metaphase plate congression (GO:0007080)3.22082155
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.21289559
71serine family amino acid catabolic process (GO:0009071)3.21245054
72aerobic respiration (GO:0009060)3.20906167
73pseudouridine synthesis (GO:0001522)3.17880955
74DNA replication-independent nucleosome assembly (GO:0006336)3.16637917
75DNA replication-independent nucleosome organization (GO:0034724)3.16637917
76positive regulation of ligase activity (GO:0051351)3.16307914
77sulfur amino acid biosynthetic process (GO:0000097)3.15407986
78establishment of viral latency (GO:0019043)3.15401289
79regulation of mitochondrial translation (GO:0070129)3.15266611
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13828029
81histone mRNA metabolic process (GO:0008334)3.13149797
82ketone body metabolic process (GO:1902224)3.12057838
83cellular respiration (GO:0045333)3.11953959
84quinone biosynthetic process (GO:1901663)3.07993520
85ubiquinone biosynthetic process (GO:0006744)3.07993520
86regulation of helicase activity (GO:0051095)3.07828727
87telomere maintenance via semi-conservative replication (GO:0032201)3.04221050
88regulation of ubiquitin-protein transferase activity (GO:0051438)3.02982027
89DNA catabolic process, exonucleolytic (GO:0000738)3.02304256
90branched-chain amino acid metabolic process (GO:0009081)3.02293387
91methionine metabolic process (GO:0006555)3.01741289
92tryptophan catabolic process (GO:0006569)3.01637421
93indole-containing compound catabolic process (GO:0042436)3.01637421
94indolalkylamine catabolic process (GO:0046218)3.01637421
95establishment of protein localization to mitochondrial membrane (GO:0090151)3.01582191
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01008852
97IMP biosynthetic process (GO:0006188)3.00521075
98lactate metabolic process (GO:0006089)2.99546810
99aspartate family amino acid metabolic process (GO:0009066)2.99429546
100L-serine metabolic process (GO:0006563)2.98798332
1012-oxoglutarate metabolic process (GO:0006103)2.97706125
102cysteine metabolic process (GO:0006534)2.97121884
103ATP biosynthetic process (GO:0006754)2.93948332
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93390733
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.92475914
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.92320009
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92231038
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92231038
109inner mitochondrial membrane organization (GO:0007007)2.92220100
110kynurenine metabolic process (GO:0070189)2.91197419
1117-methylguanosine mRNA capping (GO:0006370)2.91100943
112regulation of ligase activity (GO:0051340)2.91086260
113spindle checkpoint (GO:0031577)2.90756248
114methionine biosynthetic process (GO:0009086)2.90698995
115protein targeting to mitochondrion (GO:0006626)2.90548791
116transcription from mitochondrial promoter (GO:0006390)2.89583976
117replication fork processing (GO:0031297)2.88730928
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88410158
119negative regulation of ligase activity (GO:0051352)2.88410158
120folic acid-containing compound biosynthetic process (GO:0009396)2.88398792
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88273986
122mitotic spindle checkpoint (GO:0071174)2.87924909
123ubiquinone metabolic process (GO:0006743)2.87822349
124peptidyl-histidine modification (GO:0018202)2.87651747
125metaphase plate congression (GO:0051310)2.87442235
126aspartate family amino acid biosynthetic process (GO:0009067)2.87182709
127intracellular protein transmembrane import (GO:0044743)2.87075918
128telomere maintenance via telomerase (GO:0007004)2.87036775
129DNA strand elongation involved in DNA replication (GO:0006271)2.87031163
130kinetochore organization (GO:0051383)2.86394554
131regulation of coenzyme metabolic process (GO:0051196)2.86324941
132regulation of cofactor metabolic process (GO:0051193)2.86324941
133tryptophan metabolic process (GO:0006568)2.86161569
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85513417
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85513417
136establishment of protein localization to mitochondrion (GO:0072655)2.85397771
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85264304
138alpha-amino acid catabolic process (GO:1901606)2.84710934
139rRNA processing (GO:0006364)2.84325405
140formation of translation preinitiation complex (GO:0001731)2.83902216
141RNA capping (GO:0036260)2.83485759
1427-methylguanosine RNA capping (GO:0009452)2.83485759
143purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82256770
144purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82256770
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82256055
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82256055
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82256055
148protein localization to mitochondrion (GO:0070585)2.81733322
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.81178365
150negative regulation of sister chromatid segregation (GO:0033046)2.81178365
151negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81178365
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81178365
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81178365
154homocysteine metabolic process (GO:0050667)2.80847981
155protein-cofactor linkage (GO:0018065)2.79662051
156purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78812187
157amino-acid betaine metabolic process (GO:0006577)2.78680019
158maturation of SSU-rRNA (GO:0030490)2.77066335
159ribosomal small subunit assembly (GO:0000028)2.77017216
160signal transduction involved in cell cycle checkpoint (GO:0072395)2.76654838
161signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75963828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.74893093
2E2F7_22180533_ChIP-Seq_HELA_Human4.34427460
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.18827855
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.85410913
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.78481050
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78124098
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67828964
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66872652
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29477347
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.26170063
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07028372
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95665114
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88858162
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75220776
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74701282
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72242867
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66965182
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66432076
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62377838
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52553953
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45230737
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40592166
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39959794
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39755144
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.37277018
26* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34648673
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30343276
28DCP1A_22483619_ChIP-Seq_HELA_Human2.29340532
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27504659
30VDR_23849224_ChIP-Seq_CD4+_Human2.26313834
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25656094
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22039586
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.21675482
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12151668
35EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08677898
36FOXP3_21729870_ChIP-Seq_TREG_Human2.07613745
37XRN2_22483619_ChIP-Seq_HELA_Human2.06118788
38GABP_19822575_ChIP-Seq_HepG2_Human1.94733055
39AR_21909140_ChIP-Seq_LNCAP_Human1.94338370
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.94050947
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93958938
42* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93799024
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92417413
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90733372
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85542103
46ELK1_19687146_ChIP-ChIP_HELA_Human1.84874077
47ZNF274_21170338_ChIP-Seq_K562_Hela1.83766745
48EWS_26573619_Chip-Seq_HEK293_Human1.80656342
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.78522396
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77482530
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.76634253
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74761972
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74478909
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73746765
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72979917
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72418027
57* TTF2_22483619_ChIP-Seq_HELA_Human1.67467763
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65233998
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63121651
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58733291
61VDR_22108803_ChIP-Seq_LS180_Human1.58079488
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56950351
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50685467
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43774021
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.42417860
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41022610
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40052473
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35667967
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35290298
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35024841
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.34525626
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33269279
73TAF15_26573619_Chip-Seq_HEK293_Human1.32723396
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.31483291
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30784214
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30482707
77IGF1R_20145208_ChIP-Seq_DFB_Human1.30047101
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.29566235
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.26695504
80P300_19829295_ChIP-Seq_ESCs_Human1.26681008
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25944052
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.23973293
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20281585
84IRF1_19129219_ChIP-ChIP_H3396_Human1.14305246
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.09754337
86MYC_18940864_ChIP-ChIP_HL60_Human1.09746842
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09336500
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07106614
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06750118
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06192795
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05238852
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03502485
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02819361
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02658769
95KDM5A_27292631_Chip-Seq_BREAST_Human1.01642038
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01052839
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00155044
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.99983596
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.99191661
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98436765
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98056370
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.95730478
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94755860
104CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93251505
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93035909
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92349407
107GBX2_23144817_ChIP-Seq_PC3_Human0.92255225
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92236350
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91763315
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91464816
111* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90979778
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90228445
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.89763901
114* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89173430
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87760099
116FUS_26573619_Chip-Seq_HEK293_Human0.86361342
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85976341
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84494843
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83058086
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81900752
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81427607
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81279521
123HTT_18923047_ChIP-ChIP_STHdh_Human0.80241674
124CIITA_25753668_ChIP-Seq_RAJI_Human0.79945151
125SOX2_19829295_ChIP-Seq_ESCs_Human0.79916360
126NANOG_19829295_ChIP-Seq_ESCs_Human0.79916360
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78915009
128TP53_22573176_ChIP-Seq_HFKS_Human0.78772002
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78771498
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77245777
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76833989
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74627567
133* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.71148486
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69650604
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.68953724
136* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68864398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.59649073
2MP0005360_urolithiasis5.16176998
3MP0002139_abnormal_hepatobiliary_system4.96120453
4MP0005085_abnormal_gallbladder_physiolo4.16760602
5MP0005365_abnormal_bile_salt4.04169556
6MP0006036_abnormal_mitochondrial_physio3.19243240
7MP0008875_abnormal_xenobiotic_pharmacok3.10063234
8MP0006292_abnormal_olfactory_placode2.90568735
9MP0008877_abnormal_DNA_methylation2.77955043
10MP0002837_dystrophic_cardiac_calcinosis2.69395909
11MP0006035_abnormal_mitochondrial_morpho2.67875435
12MP0005332_abnormal_amino_acid2.67421116
13MP0003195_calcinosis2.66789227
14MP0003646_muscle_fatigue2.48604666
15MP0004957_abnormal_blastocyst_morpholog2.47294615
16MP0003186_abnormal_redox_activity2.40578471
17MP0009697_abnormal_copulation2.37467886
18MP0003693_abnormal_embryo_hatching2.29347210
19MP0003941_abnormal_skin_development2.28199260
20MP0001764_abnormal_homeostasis2.22750953
21MP0006072_abnormal_retinal_apoptosis2.21370051
22MP0010094_abnormal_chromosome_stability2.01047739
23MP0001529_abnormal_vocalization2.00978340
24MP0001293_anophthalmia1.98312148
25MP0010329_abnormal_lipoprotein_level1.86042232
26MP0008058_abnormal_DNA_repair1.76625848
27MP0003123_paternal_imprinting1.75747243
28MP0005266_abnormal_metabolism1.75254140
29MP0003786_premature_aging1.74927458
30MP0003718_maternal_effect1.74662754
31MP0003880_abnormal_central_pattern1.68311112
32MP0004147_increased_porphyrin_level1.65921630
33MP0008057_abnormal_DNA_replication1.64883121
34MP0003252_abnormal_bile_duct1.61112649
35MP0003011_delayed_dark_adaptation1.58220326
36MP0003122_maternal_imprinting1.54094172
37MP0000372_irregular_coat_pigmentation1.53684427
38MP0005319_abnormal_enzyme/_coenzyme1.53424154
39MP0003136_yellow_coat_color1.52483639
40MP0004215_abnormal_myocardial_fiber1.48997642
41MP0003077_abnormal_cell_cycle1.47401676
42MP0005253_abnormal_eye_physiology1.44523296
43MP0001666_abnormal_nutrient_absorption1.43835181
44MP0009379_abnormal_foot_pigmentation1.43290030
45MP0003221_abnormal_cardiomyocyte_apopto1.43222625
46MP0003656_abnormal_erythrocyte_physiolo1.43159247
47MP0003787_abnormal_imprinting1.41993385
48MP0008932_abnormal_embryonic_tissue1.38399781
49MP0005084_abnormal_gallbladder_morpholo1.35849426
50MP0004043_abnormal_pH_regulation1.30329004
51MP0005083_abnormal_biliary_tract1.29870805
52MP0000631_abnormal_neuroendocrine_gland1.28430880
53MP0004019_abnormal_vitamin_homeostasis1.28102989
54MP0003111_abnormal_nucleus_morphology1.27496301
55MP0005636_abnormal_mineral_homeostasis1.26889526
56MP0003937_abnormal_limbs/digits/tail_de1.26428284
57MP0005584_abnormal_enzyme/coenzyme_acti1.25241771
58MP0005376_homeostasis/metabolism_phenot1.22130674
59MP0004084_abnormal_cardiac_muscle1.21134867
60MP0005551_abnormal_eye_electrophysiolog1.20865914
61MP0008995_early_reproductive_senescence1.19284084
62MP0002736_abnormal_nociception_after1.15557850
63MP0009643_abnormal_urine_homeostasis1.13238443
64MP0009046_muscle_twitch1.13232515
65MP0002751_abnormal_autonomic_nervous1.12270358
66MP0002090_abnormal_vision1.11920977
67MP0005499_abnormal_olfactory_system1.11775175
68MP0005394_taste/olfaction_phenotype1.11775175
69MP0003567_abnormal_fetal_cardiomyocyte1.08368312
70MP0000537_abnormal_urethra_morphology1.06211637
71MP0005379_endocrine/exocrine_gland_phen1.06010811
72MP0002163_abnormal_gland_morphology1.04196828
73MP0004142_abnormal_muscle_tone1.03175669
74MP0000609_abnormal_liver_physiology1.03060087
75MP0002233_abnormal_nose_morphology1.01946715
76MP0002210_abnormal_sex_determination1.01626629
77MP0001929_abnormal_gametogenesis1.01460777
78MP0001286_abnormal_eye_development1.00597559
79MP0004036_abnormal_muscle_relaxation0.97784256
80MP0000647_abnormal_sebaceous_gland0.96391609
81MP0002118_abnormal_lipid_homeostasis0.95342971
82MP0005330_cardiomyopathy0.95327504
83MP0002876_abnormal_thyroid_physiology0.94870116
84MP0001730_embryonic_growth_arrest0.94416892
85MP0000653_abnormal_sex_gland0.93493583
86MP0005646_abnormal_pituitary_gland0.93263127
87MP0003119_abnormal_digestive_system0.92982758
88MP0001756_abnormal_urination0.92084534
89MP0001485_abnormal_pinna_reflex0.91548749
90MP0001727_abnormal_embryo_implantation0.90863086
91MP0005408_hypopigmentation0.90741817
92MP0005391_vision/eye_phenotype0.90401580
93MP0001145_abnormal_male_reproductive0.88984572
94MP0002697_abnormal_eye_size0.88924936
95MP0003890_abnormal_embryonic-extraembry0.88183694
96MP0008789_abnormal_olfactory_epithelium0.87381600
97MP0009053_abnormal_anal_canal0.85716078
98MP0002138_abnormal_hepatobiliary_system0.85147893
99MP0002277_abnormal_respiratory_mucosa0.84590515
100MP0002084_abnormal_developmental_patter0.84399766
101MP0002269_muscular_atrophy0.83528944
102MP0001188_hyperpigmentation0.83113342
103MP0000751_myopathy0.83069194
104MP0008007_abnormal_cellular_replicative0.82707721
105MP0002254_reproductive_system_inflammat0.82252332
106MP0005395_other_phenotype0.81652639
107MP0000358_abnormal_cell_content/0.80484138
108MP0001324_abnormal_eye_pigmentation0.79286020
109MP0005220_abnormal_exocrine_pancreas0.78921791
110MP0009672_abnormal_birth_weight0.77972502
111MP0003868_abnormal_feces_composition0.77833526
112MP0000598_abnormal_liver_morphology0.77731854
113MP0002085_abnormal_embryonic_tissue0.77059850
114MP0010030_abnormal_orbit_morphology0.76750117
115MP0004233_abnormal_muscle_weight0.76538334
116MP0005187_abnormal_penis_morphology0.75793726
117MP0005645_abnormal_hypothalamus_physiol0.74450577
118MP0008775_abnormal_heart_ventricle0.73843158
119MP0005389_reproductive_system_phenotype0.73311646
120MP0003121_genomic_imprinting0.72754509
121MP0000538_abnormal_urinary_bladder0.71807722
122MP0002638_abnormal_pupillary_reflex0.71381357
123MP0004133_heterotaxia0.71314350
124MP0003698_abnormal_male_reproductive0.71003731
125MP0001119_abnormal_female_reproductive0.70951590
126MP0000749_muscle_degeneration0.69805606
127MP0003938_abnormal_ear_development0.69234296
128MP0005535_abnormal_body_temperature0.69159997
129MP0006276_abnormal_autonomic_nervous0.69025595
130MP0002938_white_spotting0.68786436
131MP0003137_abnormal_impulse_conducting0.68530563
132MP0001697_abnormal_embryo_size0.67991947
133MP0001984_abnormal_olfaction0.67342985
134MP0002160_abnormal_reproductive_system0.66238846
135MP0002332_abnormal_exercise_endurance0.66118877
136MP0008872_abnormal_physiological_respon0.65906837
137MP0002078_abnormal_glucose_homeostasis0.65744904
138MP0003984_embryonic_growth_retardation0.63372770
139MP0002102_abnormal_ear_morphology0.63184668
140MP0002972_abnormal_cardiac_muscle0.62857618
141MP0005385_cardiovascular_system_phenoty0.61572321
142MP0001544_abnormal_cardiovascular_syste0.61572321
143MP0000350_abnormal_cell_proliferation0.60950608
144MP0002088_abnormal_embryonic_growth/wei0.60643784
145MP0002132_abnormal_respiratory_system0.60309974
146MP0005620_abnormal_muscle_contractility0.59686193
147MP0005380_embryogenesis_phenotype0.57880533
148MP0001672_abnormal_embryogenesis/_devel0.57880533
149MP0004130_abnormal_muscle_cell0.55327126
150MP0002822_catalepsy0.55146823
151MP0002080_prenatal_lethality0.54465256

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.50940020
2Acute encephalopathy (HP:0006846)5.38042779
3Abnormal mitochondria in muscle tissue (HP:0008316)5.33341943
4Abnormality of glycolysis (HP:0004366)5.29518996
5Increased serum pyruvate (HP:0003542)5.29518996
6Cerebral edema (HP:0002181)4.74236967
7Mitochondrial inheritance (HP:0001427)4.59196720
8Progressive macrocephaly (HP:0004481)4.58926547
9Increased CSF lactate (HP:0002490)4.54461248
10Hepatic necrosis (HP:0002605)4.47604722
11Hepatocellular necrosis (HP:0001404)4.29516789
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.94985471
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.94985471
14Lactic acidosis (HP:0003128)3.80160167
15Hypobetalipoproteinemia (HP:0003563)3.76293579
16Hyperglycinemia (HP:0002154)3.64702418
17Hyperglycinuria (HP:0003108)3.63989680
18Lethargy (HP:0001254)3.59032220
19Increased serum lactate (HP:0002151)3.58082821
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55930968
21Abnormality of fatty-acid metabolism (HP:0004359)3.39927304
22Hyperammonemia (HP:0001987)3.38899621
23Abnormality of glycine metabolism (HP:0010895)3.32025750
24Abnormality of serine family amino acid metabolism (HP:0010894)3.32025750
25Abnormality of serum amino acid levels (HP:0003112)3.23625784
26Abnormality of the labia minora (HP:0012880)3.19658240
27Exercise intolerance (HP:0003546)3.17471436
28Respiratory failure (HP:0002878)3.17023084
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15895860
30Dicarboxylic aciduria (HP:0003215)3.15895860
31Lipid accumulation in hepatocytes (HP:0006561)3.12218564
32Abnormality of alanine metabolism (HP:0010916)3.10784127
33Hyperalaninemia (HP:0003348)3.10784127
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10784127
35Increased intramyocellular lipid droplets (HP:0012240)3.00239183
363-Methylglutaconic aciduria (HP:0003535)2.98228895
37Meckel diverticulum (HP:0002245)2.93848178
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93373016
39Increased muscle lipid content (HP:0009058)2.93220237
40Generalized aminoaciduria (HP:0002909)2.92467750
41Increased hepatocellular lipid droplets (HP:0006565)2.91810014
42Intrahepatic cholestasis (HP:0001406)2.89398414
43Hypoglycemic coma (HP:0001325)2.84422496
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80408751
45Abnormality of the ileum (HP:0001549)2.80389245
46CNS demyelination (HP:0007305)2.80362093
47Ketosis (HP:0001946)2.80308969
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78134767
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78110174
50Abnormality of urine glucose concentration (HP:0011016)2.73569405
51Glycosuria (HP:0003076)2.73569405
52Ragged-red muscle fibers (HP:0003200)2.67970985
53Metabolic acidosis (HP:0001942)2.64066682
54Leukodystrophy (HP:0002415)2.63040922
55Abnormality of pyrimidine metabolism (HP:0004353)2.59791783
56Vomiting (HP:0002013)2.59416781
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58577671
58Optic disc pallor (HP:0000543)2.56388331
59Ketoacidosis (HP:0001993)2.55199709
60Hypothermia (HP:0002045)2.52361149
61Birth length less than 3rd percentile (HP:0003561)2.50750541
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.50633761
63Palpitations (HP:0001962)2.50334507
64Abnormality of chromosome stability (HP:0003220)2.48319382
65Chromsome breakage (HP:0040012)2.47823306
66Renal Fanconi syndrome (HP:0001994)2.47749459
67Abnormality of the preputium (HP:0100587)2.47652973
68Methylmalonic aciduria (HP:0012120)2.46981300
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.46513740
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46019005
71Nausea (HP:0002018)2.44033743
72Proximal tubulopathy (HP:0000114)2.42768737
73Abnormality of methionine metabolism (HP:0010901)2.40705220
74Hypolipoproteinemia (HP:0010981)2.40186280
75Delayed CNS myelination (HP:0002188)2.39263047
76Aplastic anemia (HP:0001915)2.38701265
77Rhabdomyolysis (HP:0003201)2.38241357
78Respiratory difficulties (HP:0002880)2.38062419
79Exertional dyspnea (HP:0002875)2.37368220
80Congenital, generalized hypertrichosis (HP:0004540)2.36482574
81Pancreatic cysts (HP:0001737)2.32676030
82Pancreatic fibrosis (HP:0100732)2.29983856
83Abnormal lung lobation (HP:0002101)2.29660164
84Gout (HP:0001997)2.27210760
85Neoplasm of the adrenal gland (HP:0100631)2.25060010
86Prolonged partial thromboplastin time (HP:0003645)2.24176064
87Oral leukoplakia (HP:0002745)2.22515724
88Abnormality of sulfur amino acid metabolism (HP:0004339)2.17330286
89Hyperinsulinemic hypoglycemia (HP:0000825)2.15841026
90Pancreatic islet-cell hyperplasia (HP:0004510)2.14491106
91Macrocytic anemia (HP:0001972)2.14407388
92Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13828135
93Megaloblastic anemia (HP:0001889)2.11377293
94Microvesicular hepatic steatosis (HP:0001414)2.10541874
95Septo-optic dysplasia (HP:0100842)2.10375183
96True hermaphroditism (HP:0010459)2.08464598
97Abnormal number of erythroid precursors (HP:0012131)2.06683327
98Abnormality of nucleobase metabolism (HP:0010932)2.06552016
99Myoglobinuria (HP:0002913)2.05619233
100Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04257758
101Hypoglycemic seizures (HP:0002173)2.04001263
102Reticulocytopenia (HP:0001896)2.01274422
103Hyperbilirubinemia (HP:0002904)2.01165348
104Abnormality of vitamin B metabolism (HP:0004340)2.00709822
105Medial flaring of the eyebrow (HP:0010747)2.00048580
106Deep venous thrombosis (HP:0002625)1.99962298
107Pheochromocytoma (HP:0002666)1.99027811
108Neuroendocrine neoplasm (HP:0100634)1.98336107
109X-linked dominant inheritance (HP:0001423)1.97939757
110Renal cortical cysts (HP:0000803)1.96637358
111Emotional lability (HP:0000712)1.95212936
112Hyperphosphaturia (HP:0003109)1.94997195
113Conjunctival hamartoma (HP:0100780)1.94632824
114Hyperventilation (HP:0002883)1.94040396
115Supernumerary spleens (HP:0009799)1.93189960
116Small intestinal stenosis (HP:0012848)1.92034541
117Duodenal stenosis (HP:0100867)1.92034541
118Xanthomatosis (HP:0000991)1.91940843
119Gliosis (HP:0002171)1.91248301
120Abnormality of the anterior horn cell (HP:0006802)1.91136714
121Degeneration of anterior horn cells (HP:0002398)1.91136714
122Abnormality of cells of the erythroid lineage (HP:0012130)1.91085816
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.91013337
124Type I transferrin isoform profile (HP:0003642)1.89927265
125Colon cancer (HP:0003003)1.89660335
126Abnormality of renal resorption (HP:0011038)1.89271538
127Methylmalonic acidemia (HP:0002912)1.88914800
128Hyperuricemia (HP:0002149)1.87947540
129Increased purine levels (HP:0004368)1.87947540
130Hypoplastic pelvis (HP:0008839)1.86969531
131Volvulus (HP:0002580)1.85562152
132Molar tooth sign on MRI (HP:0002419)1.85062338
133Abnormality of midbrain morphology (HP:0002418)1.85062338
134Fat malabsorption (HP:0002630)1.83916516
135Multiple enchondromatosis (HP:0005701)1.83622603
136Homocystinuria (HP:0002156)1.82963667
137Abnormality of homocysteine metabolism (HP:0010919)1.82963667
138Abnormality of the duodenum (HP:0002246)1.81703695
139Nephroblastoma (Wilms tumor) (HP:0002667)1.80590631
140Abnormality of purine metabolism (HP:0004352)1.79932133
141Brushfield spots (HP:0001088)1.79151633
142Hypochromic microcytic anemia (HP:0004840)1.78973365
143Cerebral hypomyelination (HP:0006808)1.77695880
144Nephronophthisis (HP:0000090)1.75135146
145Embryonal renal neoplasm (HP:0011794)1.74071507
146Amniotic constriction ring (HP:0009775)1.72210015
147Abnormality of placental membranes (HP:0011409)1.72210015
148Intestinal atresia (HP:0011100)1.72032572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.52113866
2BCKDK3.85920397
3NEK13.13718895
4WEE13.13031181
5VRK22.99660119
6BUB12.80889443
7NME22.67209574
8PDK42.62034671
9PDK32.62034671
10STK162.60612511
11TSSK62.49281527
12EIF2AK32.41523172
13NME12.12362893
14NUAK12.09065519
15ACVR1B2.06628539
16SRPK12.02489691
17PASK2.02234656
18TNIK1.99961633
19BRSK21.98741384
20MKNK11.98739526
21TRIM281.94633966
22VRK11.91168083
23PBK1.83387412
24CCNB11.74782894
25MAP4K21.74270622
26CDC71.70296954
27PLK31.69679384
28ERBB31.60654266
29PLK41.51124083
30CASK1.47501737
31MAP3K121.35454435
32PDK21.34262238
33PLK21.33281575
34MAP2K71.31244451
35CDK81.31055888
36TAF11.30736362
37AKT31.26845510
38BRSK11.23587123
39MYLK1.23251532
40TGFBR11.15317689
41OBSCN1.14134019
42BRAF1.12653810
43STK38L1.08441438
44CSNK1G11.07551530
45PLK11.07138697
46FRK1.05141853
47MAP3K41.02196627
48TTK1.01567966
49MKNK20.98808065
50MAP2K40.96272251
51PIM20.96093172
52ARAF0.94761520
53DYRK20.94552336
54TAOK20.90652330
55DYRK30.89884962
56CSNK1G30.89860785
57EIF2AK20.89505560
58ZAK0.88591704
59CSNK1G20.86041717
60GRK10.84903108
61WNK30.84865797
62DAPK10.84657717
63STK390.83497794
64OXSR10.81503214
65SIK30.80284540
66PNCK0.78231355
67CSNK2A10.78198236
68GRK70.77779576
69AURKA0.75992200
70MST40.73815412
71STK30.72712375
72BMPR1B0.70841291
73AURKB0.69559509
74MARK10.68427021
75FLT30.68416550
76FGFR10.67406616
77CSNK1A1L0.67332136
78BCR0.65715478
79ABL20.64659984
80NEK90.64603982
81KSR10.64029792
82CSNK2A20.63788507
83TLK10.61864018
84ERBB40.60442061
85ATR0.60278691
86FGFR20.59818696
87LIMK10.59442265
88ALK0.58191617
89MAP3K110.56566493
90INSRR0.55964353
91EPHA40.55879016
92LATS10.55376497
93STK40.54523567
94ADRBK20.53217531
95PAK30.51811391
96CDK190.51721517
97YES10.49538865
98CDK70.46175270
99MUSK0.45873494
100PRKCE0.45766118
101PHKG20.43531076
102PHKG10.43531076
103PAK40.43283125
104PINK10.41693872
105STK240.41562850
106BMPR20.41265284
107CDK30.41147652
108PRKCG0.39971389
109AKT20.39538522
110MAPK130.39264941
111WNK40.37892379
112RPS6KA50.35459359
113MINK10.35230645
114RPS6KA40.35211327
115ADRBK10.34498296
116NLK0.33265878
117CHEK10.30933293
118CSNK1A10.30817738
119PRKDC0.30210813
120MAP3K50.30099768
121MAPK40.29449997
122MAP2K10.28198661
123PRKACB0.28031049
124RPS6KB20.27361228
125DYRK1A0.27203068
126CHEK20.26692866
127SCYL20.26686959
128ATM0.26042676
129LATS20.25750311
130TESK20.23310532
131CSNK1E0.23299087
132MAP2K60.22713746
133CDK10.22511664

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.32995909
2Proteasome_Homo sapiens_hsa030503.09608217
3Oxidative phosphorylation_Homo sapiens_hsa001902.88471635
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84075587
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78848856
6Parkinsons disease_Homo sapiens_hsa050122.65278229
7Propanoate metabolism_Homo sapiens_hsa006402.52343976
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43398505
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27791092
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17176892
11Pyruvate metabolism_Homo sapiens_hsa006202.13437218
12Ribosome_Homo sapiens_hsa030102.05520197
13DNA replication_Homo sapiens_hsa030302.00512212
14Butanoate metabolism_Homo sapiens_hsa006501.99485674
15Carbon metabolism_Homo sapiens_hsa012001.99372974
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94513095
17Fatty acid degradation_Homo sapiens_hsa000711.86536653
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.81912436
19RNA polymerase_Homo sapiens_hsa030201.81218620
20Huntingtons disease_Homo sapiens_hsa050161.80646921
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.75599547
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74074780
23Biosynthesis of amino acids_Homo sapiens_hsa012301.69810943
24Alzheimers disease_Homo sapiens_hsa050101.68371157
25Mismatch repair_Homo sapiens_hsa034301.67519709
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63489702
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61406028
28Peroxisome_Homo sapiens_hsa041461.60437529
29One carbon pool by folate_Homo sapiens_hsa006701.59696657
30Pyrimidine metabolism_Homo sapiens_hsa002401.58776419
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57314193
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53690209
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50793120
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.49990782
35Arginine biosynthesis_Homo sapiens_hsa002201.47119537
36Tryptophan metabolism_Homo sapiens_hsa003801.44800835
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39947094
38Fatty acid metabolism_Homo sapiens_hsa012121.37451049
39Spliceosome_Homo sapiens_hsa030401.33549118
40Fatty acid elongation_Homo sapiens_hsa000621.30281600
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29872022
42Folate biosynthesis_Homo sapiens_hsa007901.25803483
43Selenocompound metabolism_Homo sapiens_hsa004501.23611455
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23122967
45Protein export_Homo sapiens_hsa030601.23043728
46beta-Alanine metabolism_Homo sapiens_hsa004101.21525643
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21343753
48Base excision repair_Homo sapiens_hsa034101.19862591
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.19708258
50RNA transport_Homo sapiens_hsa030131.17312110
51Sulfur metabolism_Homo sapiens_hsa009201.14182567
52Nucleotide excision repair_Homo sapiens_hsa034201.13127863
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11119039
54Phenylalanine metabolism_Homo sapiens_hsa003601.05420773
55Arginine and proline metabolism_Homo sapiens_hsa003301.01224659
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94036394
57Pentose phosphate pathway_Homo sapiens_hsa000300.93688077
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93641691
59Glutathione metabolism_Homo sapiens_hsa004800.92719300
60Tyrosine metabolism_Homo sapiens_hsa003500.90197418
61Cardiac muscle contraction_Homo sapiens_hsa042600.88561949
62Homologous recombination_Homo sapiens_hsa034400.87025526
63Metabolic pathways_Homo sapiens_hsa011000.86968313
64Chemical carcinogenesis_Homo sapiens_hsa052040.84215445
65Purine metabolism_Homo sapiens_hsa002300.83664000
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82745942
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78772497
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.78180796
69Complement and coagulation cascades_Homo sapiens_hsa046100.75441861
70PPAR signaling pathway_Homo sapiens_hsa033200.74425995
71Vitamin B6 metabolism_Homo sapiens_hsa007500.73580539
72Oocyte meiosis_Homo sapiens_hsa041140.71301775
73RNA degradation_Homo sapiens_hsa030180.71266473
74Starch and sucrose metabolism_Homo sapiens_hsa005000.65635746
75Phototransduction_Homo sapiens_hsa047440.62748450
76Histidine metabolism_Homo sapiens_hsa003400.62671200
77Fructose and mannose metabolism_Homo sapiens_hsa000510.62489333
78Non-homologous end-joining_Homo sapiens_hsa034500.60604866
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60476209
80Vitamin digestion and absorption_Homo sapiens_hsa049770.59895112
81Retinol metabolism_Homo sapiens_hsa008300.59212372
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51634564
83Cell cycle_Homo sapiens_hsa041100.51283123
84Sulfur relay system_Homo sapiens_hsa041220.49009684
85Steroid biosynthesis_Homo sapiens_hsa001000.48511861
86Fat digestion and absorption_Homo sapiens_hsa049750.48240423
87p53 signaling pathway_Homo sapiens_hsa041150.47354568
88Basal transcription factors_Homo sapiens_hsa030220.46607892
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46414249
90Collecting duct acid secretion_Homo sapiens_hsa049660.46077500
91Nitrogen metabolism_Homo sapiens_hsa009100.44212101
92Fanconi anemia pathway_Homo sapiens_hsa034600.41121205
93Galactose metabolism_Homo sapiens_hsa000520.40306769
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.38195909
95Circadian rhythm_Homo sapiens_hsa047100.31496101
96N-Glycan biosynthesis_Homo sapiens_hsa005100.29695639
97Caffeine metabolism_Homo sapiens_hsa002320.29078393
98Nicotine addiction_Homo sapiens_hsa050330.26554474
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26036455
100TGF-beta signaling pathway_Homo sapiens_hsa043500.26025025
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24944956
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24544914
103Linoleic acid metabolism_Homo sapiens_hsa005910.22164824
104Vibrio cholerae infection_Homo sapiens_hsa051100.21107282
105mRNA surveillance pathway_Homo sapiens_hsa030150.20691667
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19352195
107Ether lipid metabolism_Homo sapiens_hsa005650.18739300
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18197417
109Mineral absorption_Homo sapiens_hsa049780.17674177
110Bile secretion_Homo sapiens_hsa049760.17461612
111Epstein-Barr virus infection_Homo sapiens_hsa051690.12341653
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11463864
113Arachidonic acid metabolism_Homo sapiens_hsa005900.11136683
114Regulation of autophagy_Homo sapiens_hsa041400.10846444

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