ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cholesterol catabolic process (GO:0006707)	6.77675803
2	sterol catabolic process (GO:0016127)	6.77675803
3	SMAD protein complex assembly (GO:0007183)	5.33900650
4	sequestering of actin monomers (GO:0042989)	5.12781384
5	RNA destabilization (GO:0050779)	5.09693693
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.02967319
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.92398824
8	regulation of oxidative stress-induced neuron death (GO:1903203)	4.82663269
9	lymphoid progenitor cell differentiation (GO:0002320)	4.80429112
10	establishment of integrated proviral latency (GO:0075713)	4.78013574
11	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.77210909
12	ATP synthesis coupled proton transport (GO:0015986)	4.60801870
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.60801870
14	lysine metabolic process (GO:0006553)	4.33343245
15	lysine catabolic process (GO:0006554)	4.33343245
16	regulation of DNA endoreduplication (GO:0032875)	4.29757252
17	regulation of translational termination (GO:0006449)	4.15918279
18	ovulation cycle (GO:0042698)	4.10430203
19	DNA deamination (GO:0045006)	4.01206311
20	ribosomal large subunit biogenesis (GO:0042273)	3.98265610
21	neurofilament cytoskeleton organization (GO:0060052)	3.92142335
22	7-methylguanosine mRNA capping (GO:0006370)	3.77531144
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.77196130
24	establishment of viral latency (GO:0019043)	3.72738669
25	tryptophan metabolic process (GO:0006568)	3.69748299
26	RNA capping (GO:0036260)	3.68425948
27	7-methylguanosine RNA capping (GO:0009452)	3.68425948
28	aspartate family amino acid catabolic process (GO:0009068)	3.66256824
29	cytokinetic process (GO:0032506)	3.61301086
30	regulation of chronic inflammatory response (GO:0002676)	3.52556028
31	positive regulation of response to oxidative stress (GO:1902884)	3.50761511
32	positive regulation of cellular response to oxidative stress (GO:1900409)	3.50761511
33	regulation of isotype switching to IgG isotypes (GO:0048302)	3.49297671
34	cellular response to ATP (GO:0071318)	3.48614969
35	serotonin metabolic process (GO:0042428)	3.43122210
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39530818
37	primary amino compound metabolic process (GO:1901160)	3.37252793
38	indole-containing compound metabolic process (GO:0042430)	3.34005868
39	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	3.33994538
40	cytokine production involved in immune response (GO:0002367)	3.30259765
41	hindbrain development (GO:0030902)	3.29336390
42	artery development (GO:0060840)	3.24497345
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.24183380
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.24183380
45	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.22601699
46	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.15420959
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.13042228
48	regulation of interleukin-13 production (GO:0032656)	3.11085371
49	negative regulation of acute inflammatory response (GO:0002674)	3.10488019
50	regulation of podosome assembly (GO:0071801)	3.09974998
51	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.09861483
52	NADH dehydrogenase complex assembly (GO:0010257)	3.08591914
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.08591914
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.08591914
55	positive regulation of organelle assembly (GO:1902117)	3.08560977
56	negative regulation of leukocyte chemotaxis (GO:0002689)	3.07979613
57	mast cell activation involved in immune response (GO:0002279)	3.06276021
58	mast cell degranulation (GO:0043303)	3.06276021
59	steroid catabolic process (GO:0006706)	3.05774445
60	production of molecular mediator of immune response (GO:0002440)	3.04605218
61	positive regulation of gastrulation (GO:2000543)	3.02962531
62	indolalkylamine metabolic process (GO:0006586)	3.00439142
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99757321
64	ether lipid metabolic process (GO:0046485)	2.96870264
65	respiratory electron transport chain (GO:0022904)	2.94108572
66	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.93929258
67	spinal cord association neuron differentiation (GO:0021527)	2.92437026
68	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.91812709
69	electron transport chain (GO:0022900)	2.90823224
70	regulation of mesoderm development (GO:2000380)	2.90431452
71	viral transcription (GO:0019083)	2.90425636
72	kidney morphogenesis (GO:0060993)	2.89112586
73	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.87105075
74	protein complex biogenesis (GO:0070271)	2.83986549
75	cornea development in camera-type eye (GO:0061303)	2.83370373
76	negative regulation of microtubule polymerization (GO:0031115)	2.82823617
77	bile acid biosynthetic process (GO:0006699)	2.80915075
78	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.80572090
79	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.79434479
80	positive regulation of viral transcription (GO:0050434)	2.78483598
81	neuroblast proliferation (GO:0007405)	2.78353379
82	growth hormone receptor signaling pathway (GO:0060396)	2.78176410
83	regulation of translational elongation (GO:0006448)	2.77884689
84	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.76518679
85	translational termination (GO:0006415)	2.76191602
86	purine deoxyribonucleotide catabolic process (GO:0009155)	2.75355400
87	regulation of cellular respiration (GO:0043457)	2.73468392
88	positive regulation of histone acetylation (GO:0035066)	2.69850985
89	regulation of MHC class II biosynthetic process (GO:0045346)	2.69447005
90	translational elongation (GO:0006414)	2.66781111
91	ribosome assembly (GO:0042255)	2.64525519
92	rRNA modification (GO:0000154)	2.63849454
93	microtubule depolymerization (GO:0007019)	2.62811035
94	positive regulation of activated T cell proliferation (GO:0042104)	2.60379524
95	apoptotic DNA fragmentation (GO:0006309)	2.60056983
96	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.58289867
97	negative regulation of T-helper cell differentiation (GO:0045623)	2.56485725
98	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.56485725
99	cotranslational protein targeting to membrane (GO:0006613)	2.55472949
100	inner ear receptor stereocilium organization (GO:0060122)	2.55401986

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.75806934
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.63165635
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.43415470
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02943432
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.81828190
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.35118479
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.72739152
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69175517
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.67199809
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66268475
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57365841
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.52034630
13	MYC_18940864_ChIP-ChIP_HL60_Human	2.48152378
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44786371
15	EWS_26573619_Chip-Seq_HEK293_Human	2.35745921
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.27530441
17	FUS_26573619_Chip-Seq_HEK293_Human	2.17779544
18	BCAT_22108803_ChIP-Seq_LS180_Human	2.17548457
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.16744716
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16067516
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.01388843
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.98767767
23	TP53_16413492_ChIP-PET_HCT116_Human	1.91486999
24	E2F7_22180533_ChIP-Seq_HELA_Human	1.77243403
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76087223
26	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.73186854
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72672772
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72573038
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67674385
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.61028688
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59543672
32	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.55642476
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.55508057
34	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.55294395
35	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.54217763
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.51750643
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49571247
38	P300_19829295_ChIP-Seq_ESCs_Human	1.49543812
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46787257
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.45561709
41	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.42920465
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42763007
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40117940
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39500944
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38605824
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35757086
47	VDR_22108803_ChIP-Seq_LS180_Human	1.34916837
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.33640244
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.25164833
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23711682
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23371097
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.23170695
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21118857
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17951669
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17951669
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13764976
57	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.12525690
58	AR_20517297_ChIP-Seq_VCAP_Human	1.11559208
59	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.10946150
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09621549
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08509366
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08339402
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08300208
64	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.08141781
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07477435
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06597578
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05132024
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04652516
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.03987420
70	EZH2_22144423_ChIP-Seq_EOC_Human	1.02628952
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02297862
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98304088
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96593663
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96188962
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.95790688
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95499200
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94810667
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93519154
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93420273
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90274089
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.90051444
82	ERA_21632823_ChIP-Seq_H3396_Human	0.89731710
83	GATA3_26560356_Chip-Seq_TH2_Human	0.88514385
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88000038
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87814054
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87814054
87	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87325262
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86864714
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.86693931
90	XRN2_22483619_ChIP-Seq_HELA_Human	0.85965569
91	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.85691645
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.85490859
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.85466644
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84533383
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.84142772
96	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83530047
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83262177
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.82522295
99	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.81724559
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.81199857

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001348_abnormal_lacrimal_gland	4.82056897
2	MP0003315_abnormal_perineum_morphology	4.13049964
3	MP0003283_abnormal_digestive_organ	4.09324812
4	MP0002138_abnormal_hepatobiliary_system	3.61265476
5	MP0009780_abnormal_chondrocyte_physiolo	3.49524344
6	MP0008007_abnormal_cellular_replicative	3.34792059
7	MP0000569_abnormal_digit_pigmentation	3.13740177
8	MP0003011_delayed_dark_adaptation	3.07828458
9	MP0005187_abnormal_penis_morphology	2.88629195
10	MP0006072_abnormal_retinal_apoptosis	2.61101211
11	MP0001873_stomach_inflammation	2.39297925
12	MP0002277_abnormal_respiratory_mucosa	2.33485335
13	MP0002876_abnormal_thyroid_physiology	2.24036230
14	MP0008775_abnormal_heart_ventricle	2.20785455
15	MP0008875_abnormal_xenobiotic_pharmacok	2.20407353
16	MP0002102_abnormal_ear_morphology	2.17714904
17	MP0008872_abnormal_physiological_respon	2.10931927
18	MP0005379_endocrine/exocrine_gland_phen	2.08076958
19	MP0001879_abnormal_lymphatic_vessel	2.01669119
20	MP0000613_abnormal_salivary_gland	1.94560732
21	MP0009379_abnormal_foot_pigmentation	1.94211724
22	MP0004145_abnormal_muscle_electrophysio	1.82176911
23	MP0001835_abnormal_antigen_presentation	1.78713208
24	MP0003890_abnormal_embryonic-extraembry	1.72451055
25	MP0003786_premature_aging	1.67915196
26	MP0004084_abnormal_cardiac_muscle	1.65147174
27	MP0003119_abnormal_digestive_system	1.64647307
28	MP0002332_abnormal_exercise_endurance	1.58072813
29	MP0002938_white_spotting	1.56316039
30	MP0009697_abnormal_copulation	1.53242884
31	MP0003718_maternal_effect	1.52812109
32	MP0004133_heterotaxia	1.42762053
33	MP0001968_abnormal_touch/_nociception	1.39527094
34	MP0003937_abnormal_limbs/digits/tail_de	1.32471122
35	MP0001919_abnormal_reproductive_system	1.26937992
36	MP0005253_abnormal_eye_physiology	1.26213648
37	MP0004808_abnormal_hematopoietic_stem	1.24818011
38	MP0005645_abnormal_hypothalamus_physiol	1.21111012
39	MP0002735_abnormal_chemical_nociception	1.20290070
40	MP0004043_abnormal_pH_regulation	1.20232398
41	MP0005084_abnormal_gallbladder_morpholo	1.18899737
42	MP0002254_reproductive_system_inflammat	1.17993510
43	MP0004142_abnormal_muscle_tone	1.15802552
44	MP0001529_abnormal_vocalization	1.15050728
45	MP0000427_abnormal_hair_cycle	1.14672525
46	MP0005360_urolithiasis	1.12973291
47	MP0004215_abnormal_myocardial_fiber	1.11952329
48	MP0009053_abnormal_anal_canal	1.11395031
49	MP0002932_abnormal_joint_morphology	1.09251231
50	MP0008877_abnormal_DNA_methylation	1.01870548
51	MP0000467_abnormal_esophagus_morphology	1.01595927
52	MP0000685_abnormal_immune_system	1.01260637
53	MP0002837_dystrophic_cardiac_calcinosis	1.00215701
54	MP0005167_abnormal_blood-brain_barrier	0.98449242
55	MP0008058_abnormal_DNA_repair	0.97649711
56	MP0005646_abnormal_pituitary_gland	0.96819591
57	MP0003252_abnormal_bile_duct	0.96031401
58	MP0000955_abnormal_spinal_cord	0.95717773
59	MP0009745_abnormal_behavioral_response	0.90577221
60	MP0005671_abnormal_response_to	0.90139984
61	MP0002282_abnormal_trachea_morphology	0.89354451
62	MP0002736_abnormal_nociception_after	0.88496764
63	MP0002184_abnormal_innervation	0.85503713
64	MP0005174_abnormal_tail_pigmentation	0.84608305
65	MP0001905_abnormal_dopamine_level	0.84008391
66	MP0002234_abnormal_pharynx_morphology	0.79611178
67	MP0002733_abnormal_thermal_nociception	0.76206482
68	MP0001293_anophthalmia	0.75771837
69	MP0005551_abnormal_eye_electrophysiolog	0.74329043
70	MP0002822_catalepsy	0.74261866
71	MP0005389_reproductive_system_phenotype	0.73481861
72	MP0001243_abnormal_dermal_layer	0.72902283
73	MP0002638_abnormal_pupillary_reflex	0.71470715
74	MP0001340_abnormal_eyelid_morphology	0.71461682
75	MP0001663_abnormal_digestive_system	0.70702386
76	MP0000372_irregular_coat_pigmentation	0.68555753
77	MP0001727_abnormal_embryo_implantation	0.68017937
78	MP0010678_abnormal_skin_adnexa	0.67795033
79	MP0003638_abnormal_response/metabolism_	0.66593438
80	MP0000383_abnormal_hair_follicle	0.66028453
81	MP0004019_abnormal_vitamin_homeostasis	0.64968308
82	MP0010094_abnormal_chromosome_stability	0.64872441
83	MP0002085_abnormal_embryonic_tissue	0.63696257
84	MP0003943_abnormal_hepatobiliary_system	0.62651286
85	MP0002088_abnormal_embryonic_growth/wei	0.59949957
86	MP0005220_abnormal_exocrine_pancreas	0.59915540
87	MP0002751_abnormal_autonomic_nervous	0.58913568
88	MP0001800_abnormal_humoral_immune	0.58836968
89	MP0000631_abnormal_neuroendocrine_gland	0.57852131
90	MP0008995_early_reproductive_senescence	0.57179933
91	MP0005000_abnormal_immune_tolerance	0.55634925
92	MP0001672_abnormal_embryogenesis/_devel	0.54780256
93	MP0005380_embryogenesis_phenotype	0.54780256
94	MP0003646_muscle_fatigue	0.52856435
95	MP0003984_embryonic_growth_retardation	0.51475162
96	MP0000647_abnormal_sebaceous_gland	0.51377730
97	MP0001697_abnormal_embryo_size	0.50879604
98	MP0002396_abnormal_hematopoietic_system	0.50822155
99	MP0003938_abnormal_ear_development	0.49640879
100	MP0002067_abnormal_sensory_capabilities	0.49639023

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	7.20658587
2	Panhypogammaglobulinemia (HP:0003139)	4.83400104
3	Delayed CNS myelination (HP:0002188)	4.60651207
4	Congenital, generalized hypertrichosis (HP:0004540)	4.20460107
5	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.97462050
6	Agammaglobulinemia (HP:0004432)	3.74245795
7	Abnormality of lateral ventricle (HP:0030047)	3.69908763
8	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.57524110
9	Recurrent cutaneous fungal infections (HP:0011370)	3.56875153
10	Chronic mucocutaneous candidiasis (HP:0002728)	3.56875153
11	Premature ovarian failure (HP:0008209)	3.36916169
12	Dry hair (HP:0011359)	3.28411743
13	Increased hepatocellular lipid droplets (HP:0006565)	3.23914425
14	Lipid accumulation in hepatocytes (HP:0006561)	3.22383077
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.08875906
16	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	3.08826508
17	Spondylolisthesis (HP:0003302)	3.07895173
18	Fibular aplasia (HP:0002990)	3.05435177
19	Abnormality of secondary sexual hair (HP:0009888)	3.05396980
20	Abnormality of the axillary hair (HP:0100134)	3.05396980
21	Fair hair (HP:0002286)	3.00397792
22	Fatigue (HP:0012378)	2.99440146
23	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.96418725
24	Sensory axonal neuropathy (HP:0003390)	2.96368384
25	Abnormality of T cell physiology (HP:0011840)	2.92759798
26	Intrahepatic cholestasis (HP:0001406)	2.86540948
27	Agnosia (HP:0010524)	2.82939459
28	Pendular nystagmus (HP:0012043)	2.82821676
29	Hypoplasia of the ulna (HP:0003022)	2.79577510
30	Steatorrhea (HP:0002570)	2.75629342
31	Aplasia involving bones of the upper limbs (HP:0009823)	2.74856885
32	Aplasia of the phalanges of the hand (HP:0009802)	2.74856885
33	Aplasia involving bones of the extremities (HP:0009825)	2.74856885
34	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.74790158
35	Hypoplasia of the uterus (HP:0000013)	2.74134321
36	Progressive inability to walk (HP:0002505)	2.73193735
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.71908368
38	Anophthalmia (HP:0000528)	2.71134154
39	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.68130981
40	Mitochondrial inheritance (HP:0001427)	2.65366564
41	Renal Fanconi syndrome (HP:0001994)	2.59902833
42	Pancreatic cysts (HP:0001737)	2.59371862
43	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.55969573
44	Broad-based gait (HP:0002136)	2.55777692
45	Exertional dyspnea (HP:0002875)	2.55019018
46	Oligodactyly (hands) (HP:0001180)	2.54899728
47	Acute necrotizing encephalopathy (HP:0006965)	2.46506571
48	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.45711092
49	Abnormality of the 2nd finger (HP:0004100)	2.45629501
50	Clumsiness (HP:0002312)	2.40759133
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39570981
52	Abnormality of alanine metabolism (HP:0010916)	2.39570981
53	Hyperalaninemia (HP:0003348)	2.39570981
54	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.38627888
55	Increased CSF lactate (HP:0002490)	2.37478973
56	Abnormal mitochondria in muscle tissue (HP:0008316)	2.34551473
57	Neonatal onset (HP:0003623)	2.32397615
58	Abnormality of the renal cortex (HP:0011035)	2.32145011
59	Increased intramyocellular lipid droplets (HP:0012240)	2.30610659
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29485571
61	Inability to walk (HP:0002540)	2.27998895
62	Spastic diplegia (HP:0001264)	2.26218638
63	Forearm undergrowth (HP:0009821)	2.26180769
64	Progressive macrocephaly (HP:0004481)	2.24305442
65	Abnormality of the anterior horn cell (HP:0006802)	2.22346470
66	Degeneration of anterior horn cells (HP:0002398)	2.22346470
67	Abnormality of small intestinal villus morphology (HP:0011472)	2.22254806
68	Villous atrophy (HP:0011473)	2.22254806
69	Increased serum lactate (HP:0002151)	2.19275058
70	Metaphyseal dysplasia (HP:0100255)	2.16742177
71	Generalized hypopigmentation of hair (HP:0011358)	2.15764128
72	Ridged nail (HP:0001807)	2.15418386
73	Epileptic encephalopathy (HP:0200134)	2.15191596
74	3-Methylglutaconic aciduria (HP:0003535)	2.14521073
75	Viral hepatitis (HP:0006562)	2.12879361
76	Adactyly (HP:0009776)	2.11439405
77	Abnormality of the pupil (HP:0000615)	2.05361338
78	Recurrent viral infections (HP:0004429)	2.05297606
79	Increased muscle lipid content (HP:0009058)	2.03118774
80	Encephalitis (HP:0002383)	1.98128044
81	Abnormal pancreas size (HP:0012094)	1.97596005
82	Woolly hair (HP:0002224)	1.96204233
83	Thyroiditis (HP:0100646)	1.95449276
84	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.93978043
85	Pancreatic fibrosis (HP:0100732)	1.92264021
86	Severe combined immunodeficiency (HP:0004430)	1.88080449
87	Acute encephalopathy (HP:0006846)	1.82217128
88	Optic disc pallor (HP:0000543)	1.80895442
89	Fat malabsorption (HP:0002630)	1.79748154
90	Hypoplasia of the radius (HP:0002984)	1.79667694
91	True hermaphroditism (HP:0010459)	1.79514156
92	Opisthotonus (HP:0002179)	1.77655086
93	Wide intermamillary distance (HP:0006610)	1.75662678
94	Neonatal respiratory distress (HP:0002643)	1.75257080
95	Delayed myelination (HP:0012448)	1.71029071
96	Constricted visual fields (HP:0001133)	1.70964301
97	Nephronophthisis (HP:0000090)	1.70798981
98	Impaired proprioception (HP:0010831)	1.70641766
99	Large eyes (HP:0001090)	1.69737774
100	Short femoral neck (HP:0100864)	1.68185701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	6.20872349
2	DYRK3	5.18337511
3	MST4	3.88354141
4	CDK8	3.81892855
5	TGFBR1	3.62364721
6	FLT3	2.54716977
7	TNIK	2.47091605
8	PLK2	2.42854346
9	ZAK	2.42037727
10	KIT	2.40177936
11	TSSK6	2.38131717
12	MAP3K12	2.17556270
13	BCKDK	2.08633577
14	CDK19	1.95397080
15	PBK	1.85718977
16	MAPKAPK3	1.83776047
17	GRK1	1.83344058
18	SCYL2	1.83194078
19	EEF2K	1.79180562
20	WNK4	1.77792798
21	CDC7	1.70508490
22	ACVR1B	1.62386172
23	BRD4	1.53890798
24	TLK1	1.44720072
25	MET	1.39101736
26	SRPK1	1.36960796
27	LRRK2	1.25576421
28	WNK1	1.23841443
29	CDK9	1.18640129
30	MAPKAPK5	1.16838104
31	VRK2	1.15904113
32	MAPK13	1.13572403
33	RPS6KB2	1.12162183
34	FRK	1.10673614
35	NME1	1.08483817
36	PRKCI	1.08259289
37	MAP4K2	0.99868337
38	STK10	0.95525023
39	PLK3	0.94079274
40	EIF2AK3	0.92034061
41	BMPR2	0.91763457
42	STK16	0.83215119
43	ERBB3	0.81284760
44	TRPM7	0.80858226
45	NUAK1	0.69527050
46	VRK1	0.65096785
47	MARK1	0.62532678
48	CDK7	0.61403655
49	PIK3CG	0.59076618
50	LIMK1	0.55315961
51	MAP2K7	0.53065799
52	ABL2	0.51456459
53	ERBB4	0.51454628
54	PRKACB	0.50827049
55	STK4	0.48702125
56	PLK4	0.48625198
57	MKNK1	0.48121157
58	DYRK2	0.46375740
59	SYK	0.46370732
60	CSF1R	0.46296411
61	PRKCE	0.45246853
62	TEC	0.43087563
63	RPS6KA4	0.42695393
64	PLK1	0.40161181
65	PASK	0.39895545
66	CSNK1A1	0.39751540
67	CHEK2	0.39684174
68	AURKB	0.39105749
69	OXSR1	0.37381052
70	WNK3	0.36286184
71	PNCK	0.35114177
72	CSNK1E	0.34985157
73	CSNK2A2	0.34444212
74	STK38L	0.33118836
75	ILK	0.32957050
76	AKT2	0.30257098
77	MAP3K4	0.30042482
78	MYLK	0.29717530
79	CAMK2B	0.29694590
80	ADRBK1	0.28066497
81	MAP3K11	0.27370122
82	PRKG1	0.27002855
83	ADRBK2	0.26302972
84	MINK1	0.23628475
85	PRKCG	0.22915313
86	ITK	0.21086329
87	ATR	0.20903727
88	RPS6KB1	0.20691534
89	DAPK1	0.20679036
90	RPS6KA5	0.19336820
91	STK39	0.16984704
92	STK11	0.16378396
93	DDR2	0.16233281
94	DAPK2	0.15564180
95	ABL1	0.14936340
96	CDK3	0.14539528
97	CSNK1G3	0.13271741
98	CAMK2A	0.13097385
99	PAK4	0.12593821
100	ROCK1	0.12159585

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.36678722
2	Allograft rejection_Homo sapiens_hsa05330	3.93961281
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.89400744
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.82938342
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.99374512
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93279807
7	Ribosome_Homo sapiens_hsa03010	2.66547152
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.54435651
9	Basal transcription factors_Homo sapiens_hsa03022	2.54419466
10	Parkinsons disease_Homo sapiens_hsa05012	2.44243731
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.32933755
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.23730879
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.18934947
14	RNA polymerase_Homo sapiens_hsa03020	2.00223168
15	Proteasome_Homo sapiens_hsa03050	1.94061841
16	Protein export_Homo sapiens_hsa03060	1.93617415
17	Huntingtons disease_Homo sapiens_hsa05016	1.90867678
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.90518526
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90406235
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.85712829
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.79306298
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75309141
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.73975029
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71893686
25	Alzheimers disease_Homo sapiens_hsa05010	1.58405301
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.42494058
27	Viral myocarditis_Homo sapiens_hsa05416	1.38660494
28	RNA degradation_Homo sapiens_hsa03018	1.38275762
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20108285
30	Olfactory transduction_Homo sapiens_hsa04740	1.08785417
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04897355
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04306602
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.02028604
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.94996831
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90873960
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88945363
37	One carbon pool by folate_Homo sapiens_hsa00670	0.87205809
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.86623732
39	Spliceosome_Homo sapiens_hsa03040	0.83416809
40	Regulation of autophagy_Homo sapiens_hsa04140	0.83089180
41	Phototransduction_Homo sapiens_hsa04744	0.82827995
42	Leishmaniasis_Homo sapiens_hsa05140	0.81461365
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79857395
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.74368343
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74202359
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70361056
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68374333
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67867436
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.67196721
50	Alcoholism_Homo sapiens_hsa05034	0.67018326
51	Tight junction_Homo sapiens_hsa04530	0.63204749
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62038265
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.61929445
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.60740777
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60675222
56	RNA transport_Homo sapiens_hsa03013	0.53754471
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.53571247
58	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53376042
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52126152
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50603877
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50502701
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48663444
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45705936
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.44905198
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.44682980
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.44151720
67	Phagosome_Homo sapiens_hsa04145	0.43836564
68	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.43374820
69	Nicotine addiction_Homo sapiens_hsa05033	0.42855804
70	Peroxisome_Homo sapiens_hsa04146	0.41709992
71	Tuberculosis_Homo sapiens_hsa05152	0.39801955
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37920392
73	Morphine addiction_Homo sapiens_hsa05032	0.37604525
74	Herpes simplex infection_Homo sapiens_hsa05168	0.35441683
75	Circadian entrainment_Homo sapiens_hsa04713	0.33597600
76	Serotonergic synapse_Homo sapiens_hsa04726	0.33497961
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33036811
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.33020402
79	Sulfur metabolism_Homo sapiens_hsa00920	0.31789511
80	DNA replication_Homo sapiens_hsa03030	0.28924611
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.28872907
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27083314
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.26618309
84	Purine metabolism_Homo sapiens_hsa00230	0.24948746
85	Metabolic pathways_Homo sapiens_hsa01100	0.24343720
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23313184
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22998796
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20912618
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.19648598
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.19520686
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.18826047
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.18654947
93	Legionellosis_Homo sapiens_hsa05134	0.17208340
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.17017595
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.14557899
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.14217789
97	Toxoplasmosis_Homo sapiens_hsa05145	0.13645133
98	Fatty acid degradation_Homo sapiens_hsa00071	0.13107997
99	Amphetamine addiction_Homo sapiens_hsa05031	0.11921509
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.11043335

MRPL50P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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