MRPL51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04092088
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.91856843
3ATP synthesis coupled proton transport (GO:0015986)5.75791300
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.75791300
5chaperone-mediated protein transport (GO:0072321)5.73396320
6ribosomal small subunit biogenesis (GO:0042274)5.50722290
7respiratory electron transport chain (GO:0022904)5.34529794
8electron transport chain (GO:0022900)5.23690190
9viral transcription (GO:0019083)5.06676815
10DNA deamination (GO:0045006)5.03434904
11translational termination (GO:0006415)4.92364187
12ribosomal small subunit assembly (GO:0000028)4.87322648
13proteasome assembly (GO:0043248)4.75855232
14ribosomal large subunit biogenesis (GO:0042273)4.48679601
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39580248
16cotranslational protein targeting to membrane (GO:0006613)4.35085803
17protein targeting to ER (GO:0045047)4.30995962
18translational elongation (GO:0006414)4.29409763
19regulation of mitochondrial translation (GO:0070129)4.25976167
20oxidative phosphorylation (GO:0006119)4.21477403
21establishment of integrated proviral latency (GO:0075713)4.16372353
22protein localization to endoplasmic reticulum (GO:0070972)4.09760322
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09441265
24maturation of SSU-rRNA (GO:0030490)4.08596014
25rRNA modification (GO:0000154)4.07955953
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.04443207
27NADH dehydrogenase complex assembly (GO:0010257)4.04443207
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.04443207
29* translation (GO:0006412)3.97763570
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.91870055
31termination of RNA polymerase III transcription (GO:0006386)3.91870055
32ribonucleoprotein complex biogenesis (GO:0022613)3.91067712
33protein complex biogenesis (GO:0070271)3.88545158
34viral life cycle (GO:0019058)3.88152459
35cellular protein complex disassembly (GO:0043624)3.83964015
36translational initiation (GO:0006413)3.83573679
37mitochondrial respiratory chain complex assembly (GO:0033108)3.72807645
38protein targeting to membrane (GO:0006612)3.70687896
39cellular component biogenesis (GO:0044085)3.68483404
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66290701
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60570594
42DNA damage response, detection of DNA damage (GO:0042769)3.55362297
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.52932291
44GTP biosynthetic process (GO:0006183)3.52818023
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.52581754
46protein neddylation (GO:0045116)3.51457786
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50565127
48establishment of viral latency (GO:0019043)3.45093710
49cullin deneddylation (GO:0010388)3.44963288
50DNA strand elongation involved in DNA replication (GO:0006271)3.44653859
51inner mitochondrial membrane organization (GO:0007007)3.43605590
52regulation of cellular amino acid metabolic process (GO:0006521)3.34931694
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34290318
54positive regulation of ligase activity (GO:0051351)3.33665394
55mRNA catabolic process (GO:0006402)3.33531522
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33324188
57ubiquinone biosynthetic process (GO:0006744)3.33030200
58quinone biosynthetic process (GO:1901663)3.33030200
59rRNA methylation (GO:0031167)3.32302362
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32219250
61DNA strand elongation (GO:0022616)3.31593931
62daunorubicin metabolic process (GO:0044597)3.31345713
63polyketide metabolic process (GO:0030638)3.31345713
64doxorubicin metabolic process (GO:0044598)3.31345713
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30602458
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29613785
67negative regulation of ligase activity (GO:0051352)3.29613785
68pseudouridine synthesis (GO:0001522)3.29121638
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28459682
70histone exchange (GO:0043486)3.28284085
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27519317
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27519317
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27519317
74cytochrome complex assembly (GO:0017004)3.26472456
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25973643
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25973643
77aerobic respiration (GO:0009060)3.25864871
78protein targeting to mitochondrion (GO:0006626)3.24758859
79rRNA processing (GO:0006364)3.22844609
80DNA replication checkpoint (GO:0000076)3.22544132
81regulation of ubiquitin-protein transferase activity (GO:0051438)3.22185196
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.22087322
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22087322
84protein complex disassembly (GO:0043241)3.21980115
85establishment of protein localization to mitochondrion (GO:0072655)3.21680889
86mitotic metaphase plate congression (GO:0007080)3.20324383
87transcription from RNA polymerase I promoter (GO:0006360)3.20316450
88ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19554145
897-methylguanosine mRNA capping (GO:0006370)3.19298064
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.18978600
91purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16855425
92kinetochore assembly (GO:0051382)3.16810123
93kinetochore organization (GO:0051383)3.16534554
94formation of translation preinitiation complex (GO:0001731)3.15902281
95protein deneddylation (GO:0000338)3.15882366
96respiratory chain complex IV assembly (GO:0008535)3.15029831
97hydrogen ion transmembrane transport (GO:1902600)3.14595918
98ribosome biogenesis (GO:0042254)3.14378247
99UTP biosynthetic process (GO:0006228)3.14332656
100purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12962973
101RNA capping (GO:0036260)3.12138643
1027-methylguanosine RNA capping (GO:0009452)3.12138643
103RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11391835
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11391835
105spliceosomal snRNP assembly (GO:0000387)3.10878041
106transcription-coupled nucleotide-excision repair (GO:0006283)3.10603915
107rRNA metabolic process (GO:0016072)3.10310809
108RNA catabolic process (GO:0006401)3.09901792
109regulation of ligase activity (GO:0051340)3.09138691
110macromolecular complex disassembly (GO:0032984)3.08750021
111ATP biosynthetic process (GO:0006754)3.06580397
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01910847
113guanosine-containing compound biosynthetic process (GO:1901070)3.00481080
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98701595
115telomere maintenance via semi-conservative replication (GO:0032201)2.98525723
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97958472
117protein localization to mitochondrion (GO:0070585)2.96667062
118CENP-A containing nucleosome assembly (GO:0034080)2.95381057
119ubiquinone metabolic process (GO:0006743)2.94249615
120nucleobase-containing small molecule interconversion (GO:0015949)2.93023729
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91699030
122chromatin remodeling at centromere (GO:0031055)2.90822160
123spliceosomal complex assembly (GO:0000245)2.90727761
124termination of RNA polymerase I transcription (GO:0006363)2.90483249
125transcription elongation from RNA polymerase I promoter (GO:0006362)2.89830316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.76837884
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11565015
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.00673249
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.82740546
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79486191
6E2F7_22180533_ChIP-Seq_HELA_Human3.69794728
7* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50673799
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.43423044
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.42274118
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34422452
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30265690
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21128044
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.08123157
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04597338
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92634079
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77989104
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74969643
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71396013
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57511077
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49078376
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39354666
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30782764
23* VDR_23849224_ChIP-Seq_CD4+_Human2.29454522
24DCP1A_22483619_ChIP-Seq_HELA_Human2.29398802
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.29027872
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28901202
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.24722835
28XRN2_22483619_ChIP-Seq_HELA_Human2.11719923
29FOXP3_21729870_ChIP-Seq_TREG_Human2.02375146
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00193042
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97260635
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96496924
33TTF2_22483619_ChIP-Seq_HELA_Human1.90950948
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89546316
35* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89040748
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88835327
37ELK1_19687146_ChIP-ChIP_HELA_Human1.88432081
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75208779
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.70622340
40* GABP_19822575_ChIP-Seq_HepG2_Human1.70576299
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67147194
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66660415
43* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57864788
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55806949
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.55620724
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52598922
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47162918
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45810834
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45810834
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45810834
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41310585
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39663428
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39600529
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37940543
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36071192
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.35124450
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34796923
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34750367
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31807901
60* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30964377
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30177092
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27636278
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27091345
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24531767
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24402137
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20820315
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15659684
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13873795
69MYC_18940864_ChIP-ChIP_HL60_Human1.13440369
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11135563
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10738693
72IRF1_19129219_ChIP-ChIP_H3396_Human1.08904136
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06825971
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06564107
75* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06513260
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05690488
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03710985
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.03052714
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02920935
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01179287
81AR_21909140_ChIP-Seq_LNCAP_Human1.01135161
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99834169
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.99079890
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97029409
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96758811
86* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95448760
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.95070923
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92829278
89* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92003154
90VDR_22108803_ChIP-Seq_LS180_Human0.90365775
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89614768
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88340908
93KDM5A_27292631_Chip-Seq_BREAST_Human0.87928886
94* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86837696
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86457935
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85611098
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85517930
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.84361583
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.84202251
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83976643
101CIITA_25753668_ChIP-Seq_RAJI_Human0.82651595
102* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82019175
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81972018
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81658222
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81093191
106* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80787297
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78675561
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78095919
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75489969
110EWS_26573619_Chip-Seq_HEK293_Human0.75148003
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.72331231
112ELF5_23300383_ChIP-Seq_T47D_Human0.69694009
113ZNF263_19887448_ChIP-Seq_K562_Human0.68438127
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.66152401
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.65483784
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64928064
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64326623
118* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62441767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.78854868
2MP0003646_muscle_fatigue3.47088540
3MP0003806_abnormal_nucleotide_metabolis3.35571383
4MP0006036_abnormal_mitochondrial_physio3.26905917
5MP0004957_abnormal_blastocyst_morpholog3.13725887
6MP0009379_abnormal_foot_pigmentation3.01198568
7MP0003186_abnormal_redox_activity2.77667790
8MP0006035_abnormal_mitochondrial_morpho2.77184406
9MP0003136_yellow_coat_color2.73861933
10MP0000749_muscle_degeneration2.66643839
11MP0003011_delayed_dark_adaptation2.46029939
12MP0008058_abnormal_DNA_repair2.33915597
13MP0003718_maternal_effect2.32929849
14MP0008932_abnormal_embryonic_tissue2.27630813
15MP0003111_abnormal_nucleus_morphology2.24990407
16MP0003077_abnormal_cell_cycle2.15772200
17MP0010094_abnormal_chromosome_stability2.13915179
18MP0000750_abnormal_muscle_regeneration2.08639339
19MP0002837_dystrophic_cardiac_calcinosis2.07257476
20MP0005330_cardiomyopathy2.05411369
21MP0000372_irregular_coat_pigmentation2.04118786
22MP0002132_abnormal_respiratory_system2.03109805
23MP0004215_abnormal_myocardial_fiber1.94901512
24MP0001293_anophthalmia1.93350253
25MP0004381_abnormal_hair_follicle1.80733007
26MP0004084_abnormal_cardiac_muscle1.80179029
27MP0008057_abnormal_DNA_replication1.77964943
28MP0002332_abnormal_exercise_endurance1.76845532
29MP0003786_premature_aging1.66620162
30MP0006292_abnormal_olfactory_placode1.65408746
31MP0006072_abnormal_retinal_apoptosis1.55626554
32MP0004147_increased_porphyrin_level1.47472673
33MP0003221_abnormal_cardiomyocyte_apopto1.45018226
34MP0003315_abnormal_perineum_morphology1.43401749
35MP0003195_calcinosis1.42755329
36MP0003123_paternal_imprinting1.39720860
37MP0004036_abnormal_muscle_relaxation1.39223418
38MP0002234_abnormal_pharynx_morphology1.38899751
39MP0001529_abnormal_vocalization1.38547995
40MP0005075_abnormal_melanosome_morpholog1.37788063
41MP0005451_abnormal_body_composition1.35094731
42MP0005670_abnormal_white_adipose1.34534956
43MP0005266_abnormal_metabolism1.32625643
44MP0003137_abnormal_impulse_conducting1.31424340
45MP0001727_abnormal_embryo_implantation1.29179744
46MP0004145_abnormal_muscle_electrophysio1.29178884
47MP0002163_abnormal_gland_morphology1.28410048
48MP0004133_heterotaxia1.27028745
49MP0003937_abnormal_limbs/digits/tail_de1.26874579
50MP0004043_abnormal_pH_regulation1.26457780
51MP0003950_abnormal_plasma_membrane1.23422963
52MP0000751_myopathy1.22978637
53MP0005084_abnormal_gallbladder_morpholo1.21502400
54MP0005410_abnormal_fertilization1.19896569
55MP0003828_pulmonary_edema1.18161292
56MP0002106_abnormal_muscle_physiology1.15257784
57MP0001764_abnormal_homeostasis1.14710601
58MP0002638_abnormal_pupillary_reflex1.14066768
59MP0003941_abnormal_skin_development1.12683584
60MP0001986_abnormal_taste_sensitivity1.12233117
61MP0001697_abnormal_embryo_size1.10592504
62MP0002127_abnormal_cardiovascular_syste1.09289327
63MP0002269_muscular_atrophy1.07673508
64MP0001346_abnormal_lacrimal_gland1.07280294
65MP0008260_abnormal_autophagy1.06193973
66MP0001286_abnormal_eye_development1.06088532
67MP0002697_abnormal_eye_size1.06077977
68MP0005394_taste/olfaction_phenotype1.05640180
69MP0005499_abnormal_olfactory_system1.05640180
70MP0003938_abnormal_ear_development1.05321737
71MP0002736_abnormal_nociception_after1.05281017
72MP0008007_abnormal_cellular_replicative1.04438395
73MP0002972_abnormal_cardiac_muscle1.02190899
74MP0004142_abnormal_muscle_tone1.02094570
75MP0003567_abnormal_fetal_cardiomyocyte1.01900402
76MP0002277_abnormal_respiratory_mucosa1.01810752
77MP0002233_abnormal_nose_morphology1.01041255
78MP0005385_cardiovascular_system_phenoty1.00286266
79MP0001544_abnormal_cardiovascular_syste1.00286266
80MP0005083_abnormal_biliary_tract0.99370511
81MP0005332_abnormal_amino_acid0.99033063
82MP0002160_abnormal_reproductive_system0.98907136
83MP0001485_abnormal_pinna_reflex0.98396310
84MP0005408_hypopigmentation0.98151397
85MP0002085_abnormal_embryonic_tissue0.96972273
86MP0000759_abnormal_skeletal_muscle0.96573063
87MP0000358_abnormal_cell_content/0.96275134
88MP0008877_abnormal_DNA_methylation0.95077039
89MP0005620_abnormal_muscle_contractility0.94966530
90MP0003656_abnormal_erythrocyte_physiolo0.94883328
91MP0008775_abnormal_heart_ventricle0.94436532
92MP0004087_abnormal_muscle_fiber0.93817663
93MP0000631_abnormal_neuroendocrine_gland0.92583160
94MP0005369_muscle_phenotype0.89971329
95MP0000762_abnormal_tongue_morphology0.89020187
96MP0001188_hyperpigmentation0.88645908
97MP0001145_abnormal_male_reproductive0.87367139
98MP0000313_abnormal_cell_death0.86250018
99MP0002095_abnormal_skin_pigmentation0.84650974
100MP0009250_abnormal_appendicular_skeleto0.84013515
101MP0002080_prenatal_lethality0.83237993
102MP0002938_white_spotting0.82990650
103MP0002111_abnormal_tail_morphology0.82202646
104MP0000653_abnormal_sex_gland0.82159676
105MP0005636_abnormal_mineral_homeostasis0.81966367
106MP0009697_abnormal_copulation0.81950212
107MP0005377_hearing/vestibular/ear_phenot0.81233409
108MP0003878_abnormal_ear_physiology0.81233409
109MP0002102_abnormal_ear_morphology0.79809973
110MP0005319_abnormal_enzyme/_coenzyme0.79618584
111MP0000343_altered_response_to0.79593086
112MP0008789_abnormal_olfactory_epithelium0.78944558
113MP0010030_abnormal_orbit_morphology0.78049056
114MP0001672_abnormal_embryogenesis/_devel0.77859500
115MP0005380_embryogenesis_phenotype0.77859500
116MP0002210_abnormal_sex_determination0.77617230
117MP0009333_abnormal_splenocyte_physiolog0.77511075
118MP0006138_congestive_heart_failure0.76084966
119MP0009053_abnormal_anal_canal0.75848744
120MP0005376_homeostasis/metabolism_phenot0.75563300
121MP0002084_abnormal_developmental_patter0.74569278
122MP0008995_early_reproductive_senescence0.74514190
123MP0001730_embryonic_growth_arrest0.74337036
124MP0000566_synostosis0.73751494
125MP0001881_abnormal_mammary_gland0.73469496
126MP0001905_abnormal_dopamine_level0.73456989
127MP0005389_reproductive_system_phenotype0.72856582
128MP0000049_abnormal_middle_ear0.72732871
129MP0003121_genomic_imprinting0.72103089
130MP0003119_abnormal_digestive_system0.71927452
131MP0000579_abnormal_nail_morphology0.71913499
132MP0000350_abnormal_cell_proliferation0.69602662
133MP0000490_abnormal_crypts_of0.69181194
134MP0003755_abnormal_palate_morphology0.67750081
135MP0010630_abnormal_cardiac_muscle0.67611985
136MP0000647_abnormal_sebaceous_gland0.67510745
137MP0003890_abnormal_embryonic-extraembry0.67289683
138MP0001929_abnormal_gametogenesis0.66689573
139MP0005253_abnormal_eye_physiology0.63994272
140MP0005379_endocrine/exocrine_gland_phen0.63397701
141MP0000537_abnormal_urethra_morphology0.63262727
142MP0002090_abnormal_vision0.63059053
143MP0005391_vision/eye_phenotype0.62607696
144MP0003984_embryonic_growth_retardation0.61345893
145MP0009672_abnormal_birth_weight0.60424894

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.79571335
2Abnormal mitochondria in muscle tissue (HP:0008316)5.27212226
3Mitochondrial inheritance (HP:0001427)5.17617624
4Hepatic necrosis (HP:0002605)4.93775199
5Hepatocellular necrosis (HP:0001404)4.92626570
6Acute encephalopathy (HP:0006846)4.88056670
7Increased CSF lactate (HP:0002490)4.69290159
8Progressive macrocephaly (HP:0004481)4.67094039
9Increased serum pyruvate (HP:0003542)4.24926752
10Abnormality of glycolysis (HP:0004366)4.24926752
11Abnormality of cells of the erythroid lineage (HP:0012130)4.23982501
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.09878058
133-Methylglutaconic aciduria (HP:0003535)4.03418156
14Increased hepatocellular lipid droplets (HP:0006565)3.99291953
15Cerebral edema (HP:0002181)3.95037092
16Abnormal number of erythroid precursors (HP:0012131)3.92685239
17Lipid accumulation in hepatocytes (HP:0006561)3.90141157
18Reticulocytopenia (HP:0001896)3.82394236
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81908431
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81908431
21Increased serum lactate (HP:0002151)3.75278224
22Exercise intolerance (HP:0003546)3.66617877
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.59037699
24Lactic acidosis (HP:0003128)3.49358343
25Respiratory failure (HP:0002878)3.43755300
26Renal Fanconi syndrome (HP:0001994)3.34423275
27Increased intramyocellular lipid droplets (HP:0012240)3.20996952
28Microvesicular hepatic steatosis (HP:0001414)3.11622326
29Increased muscle lipid content (HP:0009058)3.10549800
30Macrocytic anemia (HP:0001972)3.07384247
31Multiple enchondromatosis (HP:0005701)3.02631299
32Aplastic anemia (HP:0001915)2.89061830
33Optic disc pallor (HP:0000543)2.85278913
34Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82678636
35Dicarboxylic aciduria (HP:0003215)2.82678636
36Exertional dyspnea (HP:0002875)2.73456661
37Lethargy (HP:0001254)2.72626450
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66871242
39Colon cancer (HP:0003003)2.65921459
40Nausea (HP:0002018)2.63770519
41Pallor (HP:0000980)2.63475228
42Leukodystrophy (HP:0002415)2.63436611
43Rhabdomyolysis (HP:0003201)2.56338539
44Respiratory difficulties (HP:0002880)2.52796213
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51318600
46Progressive external ophthalmoplegia (HP:0000590)2.51013268
47Abnormality of alanine metabolism (HP:0010916)2.47134471
48Hyperalaninemia (HP:0003348)2.47134471
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47134471
50CNS demyelination (HP:0007305)2.45036344
51Degeneration of anterior horn cells (HP:0002398)2.43290599
52Abnormality of the anterior horn cell (HP:0006802)2.43290599
53Breast hypoplasia (HP:0003187)2.42908577
54Ventricular tachycardia (HP:0004756)2.41816542
55Abnormality of placental membranes (HP:0011409)2.39795142
56Amniotic constriction ring (HP:0009775)2.39795142
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37857120
58Progressive muscle weakness (HP:0003323)2.37264326
59Chromsome breakage (HP:0040012)2.29926216
60Abnormality of methionine metabolism (HP:0010901)2.29176826
61Testicular atrophy (HP:0000029)2.25470791
62Abnormality of renal resorption (HP:0011038)2.25436009
63Generalized aminoaciduria (HP:0002909)2.23605010
64Glycosuria (HP:0003076)2.23531716
65Abnormality of urine glucose concentration (HP:0011016)2.23531716
66Palpitations (HP:0001962)2.20731311
67Hyperglycinuria (HP:0003108)2.17779366
68Absent thumb (HP:0009777)2.16304217
69Septo-optic dysplasia (HP:0100842)2.15880514
70Pancytopenia (HP:0001876)2.15117292
71Hyperglycinemia (HP:0002154)2.11792508
72Proximal tubulopathy (HP:0000114)2.11783934
73X-linked dominant inheritance (HP:0001423)2.11493725
74Birth length less than 3rd percentile (HP:0003561)2.10426209
75Abnormal hemoglobin (HP:0011902)2.04849878
76Muscle hypertrophy of the lower extremities (HP:0008968)2.04616489
77Megaloblastic anemia (HP:0001889)2.04598464
78Type I transferrin isoform profile (HP:0003642)2.02932611
79Methylmalonic aciduria (HP:0012120)2.01914010
80Abnormality of the labia minora (HP:0012880)2.01893582
81Stenosis of the external auditory canal (HP:0000402)2.01440755
82Renal cortical cysts (HP:0000803)2.01176741
83Hyperphosphaturia (HP:0003109)2.00670247
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.97853520
85Sudden death (HP:0001699)1.96680725
86Myoglobinuria (HP:0002913)1.96108402
87Ragged-red muscle fibers (HP:0003200)1.95998028
88Cerebral hypomyelination (HP:0006808)1.95909337
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95835394
90Abnormal protein N-linked glycosylation (HP:0012347)1.95835394
91Abnormal protein glycosylation (HP:0012346)1.95835394
92Abnormal glycosylation (HP:0012345)1.95835394
93Oral leukoplakia (HP:0002745)1.93712188
94Abnormality of fatty-acid metabolism (HP:0004359)1.91436980
95Triphalangeal thumb (HP:0001199)1.90998473
96Congenital, generalized hypertrichosis (HP:0004540)1.90989536
97Calf muscle hypertrophy (HP:0008981)1.90109001
98Emotional lability (HP:0000712)1.88429531
99Abnormal lung lobation (HP:0002101)1.88020931
100Duplicated collecting system (HP:0000081)1.87812812
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87166699
102Vomiting (HP:0002013)1.86657464
103Muscle fiber splitting (HP:0003555)1.85111228
104Sparse eyelashes (HP:0000653)1.84722766
105Congenital ichthyosiform erythroderma (HP:0007431)1.82639413
106Horseshoe kidney (HP:0000085)1.82138178
107Cleft eyelid (HP:0000625)1.81709391
108Reduced antithrombin III activity (HP:0001976)1.79818522
109Abnormality of serum amino acid levels (HP:0003112)1.79199163
110Hypoplastic pelvis (HP:0008839)1.79094069
111Meckel diverticulum (HP:0002245)1.79084747
112Carpal bone hypoplasia (HP:0001498)1.77804505
113Abnormal number of incisors (HP:0011064)1.77776585
114Abnormality of chromosome stability (HP:0003220)1.75926226
115Absent septum pellucidum (HP:0001331)1.75755421
116Abnormality of serine family amino acid metabolism (HP:0010894)1.75527810
117Abnormality of glycine metabolism (HP:0010895)1.75527810
118Rough bone trabeculation (HP:0100670)1.74910972
119Facial cleft (HP:0002006)1.72364557
120Exercise-induced muscle cramps (HP:0003710)1.71211322
121Pancreatic fibrosis (HP:0100732)1.70813638
122Gliosis (HP:0002171)1.69610808
123Parakeratosis (HP:0001036)1.69428868
124Abnormality of the preputium (HP:0100587)1.68746913
125Pancreatic cysts (HP:0001737)1.68649327
126Sclerocornea (HP:0000647)1.68370226
127Molar tooth sign on MRI (HP:0002419)1.68291188
128Abnormality of midbrain morphology (HP:0002418)1.68291188
129Dilated cardiomyopathy (HP:0001644)1.68182397
130Secondary amenorrhea (HP:0000869)1.67337522
131Abnormality of the renal collecting system (HP:0004742)1.64826221
132Abnormality of the ileum (HP:0001549)1.64629719
133Areflexia of lower limbs (HP:0002522)1.64628602
134Lipoatrophy (HP:0100578)1.63699104
135Methylmalonic acidemia (HP:0002912)1.63598562
136Hypoglycemic coma (HP:0001325)1.63167139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.44141673
2NME24.52430333
3BUB14.12013041
4STK164.01472709
5EIF2AK12.89617218
6WEE12.85923036
7TLK12.83399179
8BCKDK2.60475346
9SRPK12.39328798
10PLK42.35021913
11NME12.33541916
12ZAK2.21395492
13PBK1.93817364
14VRK11.93251427
15OBSCN1.88194379
16IRAK31.87852787
17TAF11.83757712
18MUSK1.83561704
19PDK31.80504864
20PDK41.80504864
21TTK1.67040488
22EIF2AK31.58850239
23MAP3K121.55396015
24MYLK1.47506618
25STK38L1.44919658
26PINK11.43459995
27PDK21.42152319
28GRK71.41891648
29TESK21.39786192
30MST41.35789990
31GRK51.35304968
32PLK11.34620417
33GRK11.33511628
34BRSK21.32028606
35PIM21.30107300
36EIF2AK21.25717003
37AURKA1.16299428
38EPHA21.15538187
39STK391.10523169
40AURKB1.09765817
41TRIM281.06302653
42WNK31.03205493
43CDK71.01693849
44DYRK30.98258825
45ADRBK20.97088267
46BRAF0.95731068
47IRAK40.93804170
48TIE10.93609651
49ABL20.93321675
50NEK10.90081348
51STK40.89000060
52BLK0.88586940
53CHEK20.87617847
54WNK40.85328972
55KDR0.83963724
56PAK40.83897729
57TNIK0.82514373
58CDK190.81432067
59RPS6KB20.80208520
60LRRK20.79758356
61AKT30.77509593
62MKNK10.77413349
63MAPKAPK30.76991592
64PASK0.75935915
65CDC70.74856366
66DYRK20.74413832
67CSNK2A10.71037967
68CSNK1G30.70940510
69RPS6KA50.70192797
70MAP4K20.68674140
71DAPK10.68499374
72CSNK1G10.66195524
73TTN0.65692836
74LIMK10.63683238
75PHKG10.62924969
76PHKG20.62924969
77MKNK20.62517620
78ILK0.57736326
79PLK30.56467363
80BRSK10.56244475
81STK240.55648018
82PAK10.55523917
83IRAK20.55202755
84CSNK2A20.54795836
85NEK90.54584069
86MAP2K60.53866678
87NEK20.53041571
88CSNK1G20.51857531
89BMPR1B0.51030591
90IRAK10.49768617
91PIK3CG0.49217175
92CDK80.48310907
93TESK10.48164297
94ARAF0.46947322
95CSNK1E0.46641006
96ERBB40.44890617
97MAP2K30.44814079
98ATM0.44807448
99DAPK30.44285042
100MAP3K110.42679916
101EPHB20.42666845
102CSNK1A1L0.42432992
103PLK20.41227666
104GRK60.39831229
105MAP3K80.39270566
106CHEK10.38958200
107NUAK10.38647265
108ADRBK10.38503443
109CASK0.38314607
110MAP2K70.37969560
111PRKCI0.37859183
112CAMK2D0.37688014
113AKT20.36882921
114MAPKAPK50.36851410
115CAMK2G0.36520170
116PIK3CA0.35369442
117ALK0.35212224
118TEC0.34926862
119TSSK60.33765315
120PNCK0.31908428
121CCNB10.31681063
122ATR0.31494322
123MAP2K20.31464370
124PRKCG0.31250701
125STK100.30576199
126CDK10.29495839
127YES10.28645769
128CSNK1A10.27860500
129OXSR10.27785196
130RPS6KA40.27311203
131MINK10.26613343
132CDK20.25343996
133TGFBR10.24681836

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60375295
2Oxidative phosphorylation_Homo sapiens_hsa001904.16061942
3Parkinsons disease_Homo sapiens_hsa050123.78133524
4Proteasome_Homo sapiens_hsa030503.71748839
5RNA polymerase_Homo sapiens_hsa030203.10023638
6Huntingtons disease_Homo sapiens_hsa050162.86179001
7DNA replication_Homo sapiens_hsa030302.55402089
8Alzheimers disease_Homo sapiens_hsa050102.52129512
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47290374
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27657423
11Pyrimidine metabolism_Homo sapiens_hsa002402.18989239
12Mismatch repair_Homo sapiens_hsa034302.09414573
13Homologous recombination_Homo sapiens_hsa034402.04840384
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97426408
15Cardiac muscle contraction_Homo sapiens_hsa042601.81885440
16Nucleotide excision repair_Homo sapiens_hsa034201.80407980
17Protein export_Homo sapiens_hsa030601.78354352
18Spliceosome_Homo sapiens_hsa030401.77717772
19Propanoate metabolism_Homo sapiens_hsa006401.68540416
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57005731
21Base excision repair_Homo sapiens_hsa034101.55618253
22Vitamin B6 metabolism_Homo sapiens_hsa007501.51766740
23Basal transcription factors_Homo sapiens_hsa030221.46812055
24Fanconi anemia pathway_Homo sapiens_hsa034601.44407189
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41239492
26RNA transport_Homo sapiens_hsa030131.40178675
27Fatty acid elongation_Homo sapiens_hsa000621.36788574
28Carbon metabolism_Homo sapiens_hsa012001.31724221
29One carbon pool by folate_Homo sapiens_hsa006701.30621549
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29481797
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29300831
32Folate biosynthesis_Homo sapiens_hsa007901.29051692
33Purine metabolism_Homo sapiens_hsa002301.24289741
34Pyruvate metabolism_Homo sapiens_hsa006201.18956687
35Glutathione metabolism_Homo sapiens_hsa004801.17700696
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13830138
37Arachidonic acid metabolism_Homo sapiens_hsa005901.12213738
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11697741
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11167409
40Sulfur relay system_Homo sapiens_hsa041221.07196868
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05970777
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05181538
43RNA degradation_Homo sapiens_hsa030181.03904997
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03569123
45Fatty acid degradation_Homo sapiens_hsa000711.03511802
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99728257
47Metabolic pathways_Homo sapiens_hsa011000.98528219
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.94369842
49Non-homologous end-joining_Homo sapiens_hsa034500.90493561
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88805167
51Peroxisome_Homo sapiens_hsa041460.85838875
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85556460
53Linoleic acid metabolism_Homo sapiens_hsa005910.85168144
54Pentose phosphate pathway_Homo sapiens_hsa000300.84711801
55Fructose and mannose metabolism_Homo sapiens_hsa000510.84050611
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83140553
57Cell cycle_Homo sapiens_hsa041100.78856659
58beta-Alanine metabolism_Homo sapiens_hsa004100.74853049
59Tyrosine metabolism_Homo sapiens_hsa003500.74707929
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73482734
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72880214
62Arginine and proline metabolism_Homo sapiens_hsa003300.72549430
63Biosynthesis of amino acids_Homo sapiens_hsa012300.71380951
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.69290224
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68004246
66Sulfur metabolism_Homo sapiens_hsa009200.66841088
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66766720
68Steroid biosynthesis_Homo sapiens_hsa001000.64266325
69Regulation of autophagy_Homo sapiens_hsa041400.63826953
70Fatty acid metabolism_Homo sapiens_hsa012120.63623618
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62967760
72Phenylalanine metabolism_Homo sapiens_hsa003600.62895802
73Galactose metabolism_Homo sapiens_hsa000520.58690553
74Chemical carcinogenesis_Homo sapiens_hsa052040.57779958
75Butanoate metabolism_Homo sapiens_hsa006500.57498645
76p53 signaling pathway_Homo sapiens_hsa041150.56123505
77Systemic lupus erythematosus_Homo sapiens_hsa053220.52492156
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.49969548
79Retinol metabolism_Homo sapiens_hsa008300.49503558
80Oocyte meiosis_Homo sapiens_hsa041140.45465711
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42233522
82mRNA surveillance pathway_Homo sapiens_hsa030150.41985691
83Epstein-Barr virus infection_Homo sapiens_hsa051690.41345674
84Tryptophan metabolism_Homo sapiens_hsa003800.39966731
85N-Glycan biosynthesis_Homo sapiens_hsa005100.38830549
86Ether lipid metabolism_Homo sapiens_hsa005650.35371619
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34643830
88Basal cell carcinoma_Homo sapiens_hsa052170.34184687
89Histidine metabolism_Homo sapiens_hsa003400.33987211
90Fat digestion and absorption_Homo sapiens_hsa049750.29488437
91Selenocompound metabolism_Homo sapiens_hsa004500.28629942
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26966193
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26819345
94PPAR signaling pathway_Homo sapiens_hsa033200.26300082
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26100344
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.25124029
97Vitamin digestion and absorption_Homo sapiens_hsa049770.25089736
98Starch and sucrose metabolism_Homo sapiens_hsa005000.20712138
99Hedgehog signaling pathway_Homo sapiens_hsa043400.20068936
100Vibrio cholerae infection_Homo sapiens_hsa051100.20041287
101Phototransduction_Homo sapiens_hsa047440.19993566
102Other glycan degradation_Homo sapiens_hsa005110.17396988
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.14399085
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14032638
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13865259
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13762851
107Caffeine metabolism_Homo sapiens_hsa002320.12383299
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12335354
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.12294513
110Sphingolipid metabolism_Homo sapiens_hsa006000.12214714
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.12116640
112Alcoholism_Homo sapiens_hsa050340.10072955
113Collecting duct acid secretion_Homo sapiens_hsa049660.08844306
114Herpes simplex infection_Homo sapiens_hsa051680.08559282

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