MRPL52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.80470822
2ribosomal small subunit assembly (GO:0000028)8.64176619
3ribosomal small subunit biogenesis (GO:0042274)8.46113333
4translational termination (GO:0006415)8.45719542
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.44067477
6protein targeting to ER (GO:0045047)7.41091999
7cotranslational protein targeting to membrane (GO:0006613)7.29335749
8translational elongation (GO:0006414)7.14196020
9establishment of protein localization to endoplasmic reticulum (GO:0072599)7.02175252
10protein localization to endoplasmic reticulum (GO:0070972)6.97574145
11viral life cycle (GO:0019058)6.72467280
12maturation of SSU-rRNA (GO:0030490)6.62501919
13cellular protein complex disassembly (GO:0043624)6.49699807
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.27616385
15translational initiation (GO:0006413)6.08174632
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.96795045
17ATP synthesis coupled proton transport (GO:0015986)5.80824027
18energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80824027
19ribosomal large subunit biogenesis (GO:0042273)5.70376987
20protein complex disassembly (GO:0043241)5.54824439
21macromolecular complex disassembly (GO:0032984)5.23215116
22DNA deamination (GO:0045006)5.08160570
23* translation (GO:0006412)5.00800819
24protein targeting to membrane (GO:0006612)4.84193586
25proteasome assembly (GO:0043248)4.72960367
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.70275321
27respiratory electron transport chain (GO:0022904)4.56520278
28electron transport chain (GO:0022900)4.45739101
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.43926754
30ribonucleoprotein complex biogenesis (GO:0022613)4.37980236
31protein neddylation (GO:0045116)4.34267995
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.23364356
33mRNA catabolic process (GO:0006402)4.22298774
34protein localization to mitochondrion (GO:0070585)3.99811499
35termination of RNA polymerase III transcription (GO:0006386)3.94558143
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.94558143
37oxidative phosphorylation (GO:0006119)3.93348586
38RNA catabolic process (GO:0006401)3.88742354
39cellular component biogenesis (GO:0044085)3.87863675
40protein complex biogenesis (GO:0070271)3.80130849
41rRNA modification (GO:0000154)3.69445238
42mitochondrial respiratory chain complex assembly (GO:0033108)3.61352492
43peptidyl-histidine modification (GO:0018202)3.56848938
44respiratory chain complex IV assembly (GO:0008535)3.54121337
45formation of translation preinitiation complex (GO:0001731)3.50937809
46rRNA processing (GO:0006364)3.48965740
47water-soluble vitamin biosynthetic process (GO:0042364)3.45528789
48pyrimidine nucleotide catabolic process (GO:0006244)3.44491647
49inner mitochondrial membrane organization (GO:0007007)3.44142600
50GTP biosynthetic process (GO:0006183)3.42867084
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.42100435
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38397946
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38397946
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.37726001
55NADH dehydrogenase complex assembly (GO:0010257)3.37726001
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37726001
57maturation of 5.8S rRNA (GO:0000460)3.37005740
58rRNA metabolic process (GO:0016072)3.36660056
59base-excision repair, AP site formation (GO:0006285)3.34881210
60mitochondrial transport (GO:0006839)3.34273513
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.34059333
62regulation of mitochondrial translation (GO:0070129)3.33852618
63establishment of protein localization to membrane (GO:0090150)3.32709864
64intracellular protein transmembrane import (GO:0044743)3.29948819
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27850437
66hydrogen ion transmembrane transport (GO:1902600)3.25569873
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24071387
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23703608
69cytochrome complex assembly (GO:0017004)3.21180169
70transcription-coupled nucleotide-excision repair (GO:0006283)3.18592956
71protein targeting (GO:0006605)3.18478417
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14202331
73protein-cofactor linkage (GO:0018065)3.12283032
74UTP biosynthetic process (GO:0006228)3.12232986
75DNA damage response, detection of DNA damage (GO:0042769)3.12049607
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10545043
77iron-sulfur cluster assembly (GO:0016226)3.10263854
78metallo-sulfur cluster assembly (GO:0031163)3.10263854
79regulation of cellular amino acid metabolic process (GO:0006521)3.09620517
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08472189
81deoxyribonucleotide catabolic process (GO:0009264)3.07622148
82chromatin remodeling at centromere (GO:0031055)3.06360849
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05268154
84pseudouridine synthesis (GO:0001522)3.04805705
85spliceosomal snRNP assembly (GO:0000387)3.04653043
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02821481
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02821481
88establishment of protein localization to organelle (GO:0072594)3.01469704
89purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00784128
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00668658
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00668658
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00668658
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98747985
94ATP biosynthetic process (GO:0006754)2.94525602
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94331399
96negative regulation of ligase activity (GO:0051352)2.94331399
97establishment of integrated proviral latency (GO:0075713)2.94290271
98protein targeting to mitochondrion (GO:0006626)2.91043313
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.90985867
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90985867
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89954422
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88305599
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.87664860
104guanosine-containing compound biosynthetic process (GO:1901070)2.83094794
105establishment of protein localization to mitochondrion (GO:0072655)2.82714424
106spliceosomal complex assembly (GO:0000245)2.82678848
107ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81274219
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79693849
109response to interferon-beta (GO:0035456)2.78211464
110UTP metabolic process (GO:0046051)2.76143541
1117-methylguanosine mRNA capping (GO:0006370)2.74230009
112chaperone-mediated protein transport (GO:0072321)2.74212924
113telomere maintenance via semi-conservative replication (GO:0032201)2.70891516
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69425035
115establishment of viral latency (GO:0019043)2.69134896
116CTP biosynthetic process (GO:0006241)2.67815918
117CTP metabolic process (GO:0046036)2.67815918
118RNA capping (GO:0036260)2.67258990
1197-methylguanosine RNA capping (GO:0009452)2.67258990
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65558088
121nucleobase-containing small molecule interconversion (GO:0015949)2.62753733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.95886698
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51556392
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.16426678
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.83866850
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70936646
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.65687922
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38110436
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.33613863
9E2F7_22180533_ChIP-Seq_HELA_Human3.20341283
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06131160
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06077369
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04107774
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91381615
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90791016
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75682963
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61887372
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60649149
18XRN2_22483619_ChIP-Seq_HELA_Human2.60592991
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54455829
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42968046
21* VDR_23849224_ChIP-Seq_CD4+_Human2.35159700
22DCP1A_22483619_ChIP-Seq_HELA_Human2.32123457
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.26346649
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.24458644
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23262212
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15433239
27TTF2_22483619_ChIP-Seq_HELA_Human2.11199511
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.07693558
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03874503
30FOXP3_21729870_ChIP-Seq_TREG_Human2.01062279
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95326715
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92371589
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91566661
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.88961099
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86422407
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80783729
37* ELK1_19687146_ChIP-ChIP_HELA_Human1.79663522
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76739116
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73840832
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.72598565
41* GABP_19822575_ChIP-Seq_HepG2_Human1.70238281
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.65094940
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63589224
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60477685
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56540193
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53833487
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50429278
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49739028
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48760186
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46480049
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43373619
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43240626
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39393078
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37129143
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36511051
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28769391
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27410580
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26169235
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25676370
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24804515
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.23562107
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22340793
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21821011
64MYC_18940864_ChIP-ChIP_HL60_Human1.19645991
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.18339555
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16789763
67* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16673897
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14647822
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12970326
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12585795
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11798291
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11615138
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09632205
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09405554
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08407389
76SPI1_23547873_ChIP-Seq_NB4_Human1.08140290
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07875794
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06666947
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05579465
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02672127
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00934988
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00894271
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00055065
84* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99119050
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.98675786
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98302738
87FOXM1_23109430_ChIP-Seq_U2OS_Human0.97786554
88* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96437705
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95361884
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94389864
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93743630
92* CIITA_25753668_ChIP-Seq_RAJI_Human0.91452747
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90923466
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90769564
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90197070
96IRF1_19129219_ChIP-ChIP_H3396_Human0.90006315
97* CTCF_26484167_Chip-Seq_Bcells_Mouse0.89982968
98ZNF274_21170338_ChIP-Seq_K562_Hela0.89833962
99KDM5A_27292631_Chip-Seq_BREAST_Human0.88759368
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88142478
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87751183
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87643029
103* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85854748
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.85207575
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.85182316
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84418646
107* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83503356
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.83231295
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82653704
110VDR_21846776_ChIP-Seq_THP-1_Human0.81713731
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81367286
112STAT1_20625510_ChIP-Seq_HELA_Human0.80304675
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77397663
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76714742
115MAF_26560356_Chip-Seq_TH2_Human0.76041959
116* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75814725
117* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74726015
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.74034841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.09079284
2MP0003693_abnormal_embryo_hatching3.42157289
3MP0002132_abnormal_respiratory_system2.94311164
4MP0003186_abnormal_redox_activity2.81883806
5MP0004957_abnormal_blastocyst_morpholog2.43012399
6MP0001835_abnormal_antigen_presentation2.23394357
7MP0003315_abnormal_perineum_morphology2.15802640
8MP0002837_dystrophic_cardiac_calcinosis1.98344564
9MP0002148_abnormal_hypersensitivity_rea1.94253875
10MP0003806_abnormal_nucleotide_metabolis1.93006689
11MP0001529_abnormal_vocalization1.92774065
12MP0000490_abnormal_crypts_of1.91010009
13MP0009785_altered_susceptibility_to1.90014420
14MP0009333_abnormal_splenocyte_physiolog1.86513050
15MP0001853_heart_inflammation1.81972222
16MP0003724_increased_susceptibility_to1.79918286
17MP0006036_abnormal_mitochondrial_physio1.78132895
18MP0006035_abnormal_mitochondrial_morpho1.65950690
19MP0003436_decreased_susceptibility_to1.65603236
20MP0005084_abnormal_gallbladder_morpholo1.65441054
21MP0003656_abnormal_erythrocyte_physiolo1.64368644
22MP0002160_abnormal_reproductive_system1.63545620
23MP0005671_abnormal_response_to1.63189193
24MP0003077_abnormal_cell_cycle1.63070360
25MP0003763_abnormal_thymus_physiology1.59960721
26MP0001293_anophthalmia1.55730626
27MP0002163_abnormal_gland_morphology1.55297457
28MP0003283_abnormal_digestive_organ1.54852933
29MP0005025_abnormal_response_to1.54508409
30MP0005394_taste/olfaction_phenotype1.54499286
31MP0005499_abnormal_olfactory_system1.54499286
32MP0008932_abnormal_embryonic_tissue1.54427488
33MP0000685_abnormal_immune_system1.53109080
34MP0005075_abnormal_melanosome_morpholog1.52692690
35MP0009053_abnormal_anal_canal1.51827838
36MP0008058_abnormal_DNA_repair1.51660870
37MP0005174_abnormal_tail_pigmentation1.50639332
38MP0003941_abnormal_skin_development1.47774154
39MP0006072_abnormal_retinal_apoptosis1.45405698
40MP0005636_abnormal_mineral_homeostasis1.45339447
41MP0001905_abnormal_dopamine_level1.43981898
42MP0002736_abnormal_nociception_after1.43739367
43MP0002653_abnormal_ependyma_morphology1.42635535
44MP0010094_abnormal_chromosome_stability1.40822104
45MP0003786_premature_aging1.40503588
46MP0003011_delayed_dark_adaptation1.40430317
47MP0003123_paternal_imprinting1.39817016
48MP0005000_abnormal_immune_tolerance1.37915862
49MP0005389_reproductive_system_phenotype1.37262917
50MP0004381_abnormal_hair_follicle1.35152791
51MP0002277_abnormal_respiratory_mucosa1.33130019
52MP0006292_abnormal_olfactory_placode1.28781292
53MP0003136_yellow_coat_color1.28603062
54MP0006054_spinal_hemorrhage1.26806225
55MP0008007_abnormal_cellular_replicative1.25211771
56MP0000372_irregular_coat_pigmentation1.22616342
57MP0002938_white_spotting1.22494694
58MP0004142_abnormal_muscle_tone1.22214167
59MP0001800_abnormal_humoral_immune1.21714989
60MP0004133_heterotaxia1.21254273
61MP0003646_muscle_fatigue1.17268179
62MP0010030_abnormal_orbit_morphology1.15936482
63MP0001545_abnormal_hematopoietic_system1.15173440
64MP0005397_hematopoietic_system_phenotyp1.15173440
65MP0002723_abnormal_immune_serum1.14935963
66MP0008872_abnormal_physiological_respon1.14927596
67MP0002254_reproductive_system_inflammat1.13684694
68MP0005646_abnormal_pituitary_gland1.13526026
69MP0001919_abnormal_reproductive_system1.13430466
70MP0008875_abnormal_xenobiotic_pharmacok1.12935493
71MP0002405_respiratory_system_inflammati1.12716399
72MP0008469_abnormal_protein_level1.10843891
73MP0001188_hyperpigmentation1.10569746
74MP0005408_hypopigmentation1.09784904
75MP0003111_abnormal_nucleus_morphology1.08862257
76MP0002452_abnormal_antigen_presenting1.08810953
77MP0003195_calcinosis1.08551641
78MP0003718_maternal_effect1.08441920
79MP0005379_endocrine/exocrine_gland_phen1.07257816
80MP0010155_abnormal_intestine_physiology1.06474399
81MP0002398_abnormal_bone_marrow1.06228858
82MP0002282_abnormal_trachea_morphology1.05730244
83MP0002638_abnormal_pupillary_reflex1.05546251
84MP0002722_abnormal_immune_system1.05026494
85MP0000631_abnormal_neuroendocrine_gland1.05001277
86MP0001819_abnormal_immune_cell1.01456292
87MP0000858_altered_metastatic_potential1.01300200
88MP0000613_abnormal_salivary_gland1.00887112
89MP0000689_abnormal_spleen_morphology1.00710195
90MP0002210_abnormal_sex_determination1.00644038
91MP0001764_abnormal_homeostasis1.00295222
92MP0002420_abnormal_adaptive_immunity1.00228742
93MP0002102_abnormal_ear_morphology0.99490307
94MP0005387_immune_system_phenotype0.98547000
95MP0001790_abnormal_immune_system0.98547000
96MP0001968_abnormal_touch/_nociception0.97960924
97MP0002429_abnormal_blood_cell0.97585924
98MP0005083_abnormal_biliary_tract0.97333031
99MP0008789_abnormal_olfactory_epithelium0.96602796
100MP0000049_abnormal_middle_ear0.95803372
101MP0002234_abnormal_pharynx_morphology0.94795414
102MP0002139_abnormal_hepatobiliary_system0.94715949
103MP0001845_abnormal_inflammatory_respons0.94269840
104MP0005085_abnormal_gallbladder_physiolo0.92939152
105MP0001663_abnormal_digestive_system0.92664218
106MP0003866_abnormal_defecation0.92385735
107MP0000313_abnormal_cell_death0.92067496
108MP0000716_abnormal_immune_system0.90233345
109MP0005410_abnormal_fertilization0.89075639
110MP0003119_abnormal_digestive_system0.88135132
111MP0005332_abnormal_amino_acid0.88082757
112MP0002098_abnormal_vibrissa_morphology0.87768054
113MP0004145_abnormal_muscle_electrophysio0.86096276
114MP0002138_abnormal_hepatobiliary_system0.85691081
115MP0003567_abnormal_fetal_cardiomyocyte0.85000190
116MP0004147_increased_porphyrin_level0.84978362
117MP0002396_abnormal_hematopoietic_system0.84452631
118MP0009697_abnormal_copulation0.83559328
119MP0001485_abnormal_pinna_reflex0.83371955
120MP0002019_abnormal_tumor_incidence0.82722880
121MP0008057_abnormal_DNA_replication0.82430581
122MP0000350_abnormal_cell_proliferation0.82108373
123MP0005464_abnormal_platelet_physiology0.81610664
124MP0008877_abnormal_DNA_methylation0.81498931
125MP0001666_abnormal_nutrient_absorption0.81448975
126MP0002419_abnormal_innate_immunity0.81144196
127MP0001145_abnormal_male_reproductive0.81057228
128MP0005381_digestive/alimentary_phenotyp0.79881887
129MP0000358_abnormal_cell_content/0.79045148
130MP0003938_abnormal_ear_development0.78437548
131MP0005670_abnormal_white_adipose0.78278075
132MP0002095_abnormal_skin_pigmentation0.77284523
133MP0005551_abnormal_eye_electrophysiolog0.77265649
134MP0005451_abnormal_body_composition0.76931239
135MP0009764_decreased_sensitivity_to0.76842082
136MP0008995_early_reproductive_senescence0.76708539
137MP0009046_muscle_twitch0.76556525
138MP0000653_abnormal_sex_gland0.74146378
139MP0001727_abnormal_embryo_implantation0.73203798
140MP0002233_abnormal_nose_morphology0.70554632
141MP0003937_abnormal_limbs/digits/tail_de0.69951106
142MP0001730_embryonic_growth_arrest0.69828563
143MP0003137_abnormal_impulse_conducting0.69606579
144MP0001929_abnormal_gametogenesis0.69460528
145MP0001881_abnormal_mammary_gland0.68781629
146MP0000678_abnormal_parathyroid_gland0.68624320
147MP0008873_increased_physiological_sensi0.68344546
148MP0003121_genomic_imprinting0.67195302
149MP0002177_abnormal_outer_ear0.66045344
150MP0005645_abnormal_hypothalamus_physiol0.65880232
151MP0002111_abnormal_tail_morphology0.63894984
152MP0001697_abnormal_embryo_size0.63306760
153MP0001119_abnormal_female_reproductive0.62973955
154MP0002751_abnormal_autonomic_nervous0.61853001
155MP0005195_abnormal_posterior_eye0.61676170

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.56207574
2Abnormal number of erythroid precursors (HP:0012131)6.97676072
3Reticulocytopenia (HP:0001896)6.05788281
4Acute necrotizing encephalopathy (HP:0006965)5.20934815
5Mitochondrial inheritance (HP:0001427)5.17040674
6Increased hepatocellular lipid droplets (HP:0006565)5.11280299
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.93368522
8Macrocytic anemia (HP:0001972)4.91373698
9Pallor (HP:0000980)4.83558897
10Abnormal mitochondria in muscle tissue (HP:0008316)4.76242108
11Lipid accumulation in hepatocytes (HP:0006561)4.69024734
12Acute encephalopathy (HP:0006846)4.47044721
13Hepatocellular necrosis (HP:0001404)4.46328972
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.35805129
15Decreased activity of mitochondrial respiratory chain (HP:0008972)4.35805129
16Increased CSF lactate (HP:0002490)4.34846599
17Renal Fanconi syndrome (HP:0001994)4.21922877
18Exertional dyspnea (HP:0002875)4.20224721
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.19780960
20Progressive macrocephaly (HP:0004481)4.11300953
21Increased intramyocellular lipid droplets (HP:0012240)4.10498562
22Hepatic necrosis (HP:0002605)4.05951148
233-Methylglutaconic aciduria (HP:0003535)3.77028161
24Increased muscle lipid content (HP:0009058)3.60918693
25Respiratory difficulties (HP:0002880)3.27465708
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.24218216
27Increased serum lactate (HP:0002151)3.21560774
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.15385988
29Cerebral edema (HP:0002181)3.13522886
30Exercise intolerance (HP:0003546)3.13036300
31Lactic acidosis (HP:0003128)3.02834821
32Methylmalonic aciduria (HP:0012120)2.96414677
33Respiratory failure (HP:0002878)2.90931738
34Abnormal hemoglobin (HP:0011902)2.89691369
35Methylmalonic acidemia (HP:0002912)2.82874918
36Petechiae (HP:0000967)2.69591940
37Hyperphosphaturia (HP:0003109)2.67590105
38Aplastic anemia (HP:0001915)2.66962587
39Abnormality of renal resorption (HP:0011038)2.59343943
40Abnormality of reticulocytes (HP:0004312)2.56012126
41Breast hypoplasia (HP:0003187)2.43923404
42Oral leukoplakia (HP:0002745)2.41265776
43Abnormality of urine glucose concentration (HP:0011016)2.38887396
44Glycosuria (HP:0003076)2.38887396
45Type I transferrin isoform profile (HP:0003642)2.33641605
46Optic disc pallor (HP:0000543)2.32334098
47Hyperglycinemia (HP:0002154)2.28021512
48Increased serum pyruvate (HP:0003542)2.22312437
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20070356
50Dicarboxylic aciduria (HP:0003215)2.20070356
51Thrombocytosis (HP:0001894)2.17620320
52Woolly hair (HP:0002224)2.14773943
53Congenital, generalized hypertrichosis (HP:0004540)2.11258066
54Leukodystrophy (HP:0002415)2.10830885
55Abnormal urine phosphate concentration (HP:0012599)2.10625841
56Molar tooth sign on MRI (HP:0002419)2.09133366
57Abnormality of midbrain morphology (HP:0002418)2.09133366
58Pancreatic cysts (HP:0001737)2.08220282
5911 pairs of ribs (HP:0000878)2.07604469
60Testicular atrophy (HP:0000029)2.07579008
61Sparse eyelashes (HP:0000653)2.07574806
62Generalized aminoaciduria (HP:0002909)2.07287040
63Pancreatic fibrosis (HP:0100732)2.04176780
64Irregular epiphyses (HP:0010582)2.01211555
65Pendular nystagmus (HP:0012043)2.00765577
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97894623
67Abnormality of alanine metabolism (HP:0010916)1.97894623
68Hyperalaninemia (HP:0003348)1.97894623
69Renal tubular dysfunction (HP:0000124)1.91881563
70Abnormality of secondary sexual hair (HP:0009888)1.91859009
71Abnormality of the axillary hair (HP:0100134)1.91859009
72Depressed nasal ridge (HP:0000457)1.91319685
73Lethargy (HP:0001254)1.91291044
74Sclerocornea (HP:0000647)1.90892365
75Meckel diverticulum (HP:0002245)1.90455607
76True hermaphroditism (HP:0010459)1.90018085
77Absent thumb (HP:0009777)1.90013954
78Microvesicular hepatic steatosis (HP:0001414)1.89938032
79X-linked dominant inheritance (HP:0001423)1.88989566
80Abnormality of the anterior horn cell (HP:0006802)1.88945641
81Degeneration of anterior horn cells (HP:0002398)1.88945641
82Birth length less than 3rd percentile (HP:0003561)1.88599247
83Hypoplasia of the radius (HP:0002984)1.88180127
84Abnormality of glycolysis (HP:0004366)1.87382673
85Elevated erythrocyte sedimentation rate (HP:0003565)1.87274999
86Reduced antithrombin III activity (HP:0001976)1.87028710
87Trismus (HP:0000211)1.85430358
88Abnormality of the ileum (HP:0001549)1.82131179
89CNS demyelination (HP:0007305)1.79279581
90Abnormality of serum amino acid levels (HP:0003112)1.79234187
91Progressive microcephaly (HP:0000253)1.79153068
92Cerebral hypomyelination (HP:0006808)1.77430302
93Rough bone trabeculation (HP:0100670)1.77136586
94Opisthotonus (HP:0002179)1.76781010
95Concave nail (HP:0001598)1.76060588
96Nausea (HP:0002018)1.74998171
97Aplasia/hypoplasia of the uterus (HP:0008684)1.72937976
98Microretrognathia (HP:0000308)1.71220794
99Multiple enchondromatosis (HP:0005701)1.70178819
100Fragile nails (HP:0001808)1.69195946
101Abnormality of methionine metabolism (HP:0010901)1.69064456
102Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68853632
103Pancytopenia (HP:0001876)1.66704312
104Triphalangeal thumb (HP:0001199)1.66180092
105Horseshoe kidney (HP:0000085)1.65022896
106Abnormality of the preputium (HP:0100587)1.64869153
107Abnormal number of incisors (HP:0011064)1.63225309
108Migraine (HP:0002076)1.62633905
109Increased serum ferritin (HP:0003281)1.62561755
110IgM deficiency (HP:0002850)1.62199998
111Congenital ichthyosiform erythroderma (HP:0007431)1.61101883
112Flat capital femoral epiphysis (HP:0003370)1.60984454
113Colon cancer (HP:0003003)1.60700399
114Poor head control (HP:0002421)1.60186951
115Spinal cord compression (HP:0002176)1.59878659
116Increased IgM level (HP:0003496)1.59130340
117Progressive muscle weakness (HP:0003323)1.58889118
118Amniotic constriction ring (HP:0009775)1.58479820
119Abnormality of placental membranes (HP:0011409)1.58479820
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.57675166
121Ridged nail (HP:0001807)1.57548623
122Abnormality of the labia minora (HP:0012880)1.57433015
123Posterior subcapsular cataract (HP:0007787)1.56001442
124Gliosis (HP:0002171)1.55187489
125Abnormality of iron homeostasis (HP:0011031)1.54319455
126Emotional lability (HP:0000712)1.54303624
127Cleft eyelid (HP:0000625)1.53823730
128Muscle fiber atrophy (HP:0100295)1.53003049
129Stenosis of the external auditory canal (HP:0000402)1.50430219
130Secondary amenorrhea (HP:0000869)1.50411172
131Abnormal cartilage morphology (HP:0002763)1.47282194
132Blindness (HP:0000618)1.46639488
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.46208371
134Abnormal protein N-linked glycosylation (HP:0012347)1.46208371
135Abnormal protein glycosylation (HP:0012346)1.46208371
136Abnormal glycosylation (HP:0012345)1.46208371
137Patellar aplasia (HP:0006443)1.45760850
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.44384039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.28450120
2VRK25.38347238
3TAOK34.78024936
4TLK12.92460245
5PIM22.91952045
6STK162.88460660
7BUB12.67579927
8NME12.47815656
9EIF2AK12.35695833
10VRK12.20120353
11EPHB22.12049788
12NEK11.97480431
13WEE11.95714902
14DYRK31.85136944
15PBK1.83451792
16KDR1.70345756
17SRPK11.68945684
18MST41.60856729
19ILK1.47036033
20MAP3K111.45729302
21CSNK1G31.41937413
22MAP4K11.38323896
23IRAK31.35426387
24ARAF1.32724185
25RPS6KB21.31756683
26PLK31.27043689
27BCKDK1.25203407
28MAP4K21.22702628
29PLK41.22668423
30WNK31.20145178
31LRRK21.19562751
32ZAK1.19269143
33MUSK1.18100879
34TAF11.17400346
35MAP3K141.16854863
36TGFBR11.14880665
37MYLK1.14347968
38DYRK21.12998081
39ACVR1B1.12367765
40CSNK1G11.12360702
41MAP3K121.11592970
42CSNK1A1L1.10556906
43RPS6KA41.10380612
44MST1R1.07236377
45TESK21.07134166
46IKBKB1.06430886
47WNK41.05484804
48EIF2AK31.05394909
49MAP2K21.04973396
50CSNK1G21.04542608
51AURKB1.04071074
52TBK11.04052162
53PDK21.03884344
54PIK3CG1.00308726
55CHEK20.97283921
56TTK0.96892036
57EIF2AK20.96793888
58BRSK10.96274144
59CDK70.94838896
60TSSK60.94342678
61ABL20.93728454
62TEC0.93539688
63TXK0.91109659
64BTK0.89762001
65IKBKE0.89013254
66MAP2K70.87579484
67BRAF0.87417064
68TESK10.86025799
69BMPR1B0.85313212
70AURKA0.84813588
71TYK20.84139590
72PIM10.82611030
73ADRBK20.80652908
74BLK0.80572631
75GRK60.79348423
76KIT0.77858960
77IRAK40.77261369
78PLK10.77080876
79MKNK10.76871491
80TRIM280.76683732
81CSNK2A10.72366001
82RPS6KA50.70785775
83MAP2K60.69571017
84CDK190.68973315
85MAPKAPK30.68954379
86DAPK10.66996320
87CSNK2A20.66553796
88CDK80.64722108
89DAPK30.60475820
90SYK0.59801153
91PAK10.58534181
92LYN0.58395345
93ZAP700.56231694
94BRSK20.55288800
95GRK70.53689661
96CDC70.53184560
97PASK0.53104712
98TIE10.51684221
99STK40.51182064
100PAK40.50162604
101PRKG20.49899700
102ERN10.47261118
103INSRR0.46742155
104MAP3K30.45945636
105PIK3CA0.45555594
106CCNB10.44711395
107STK390.43928287
108OXSR10.43257008
109MAPK40.42662090
110LIMK10.41785332
111CSNK1A10.41364172
112CHEK10.41056311
113MKNK20.39724043
114ATR0.39646935
115NUAK10.39500643
116MATK0.39341804
117FLT30.39268005
118YES10.38779695
119PRKCI0.37981555
120DYRK1B0.37564775
121ADRBK10.36924036
122TNIK0.36650927
123MAP2K30.36498887
124ATM0.36256597
125MAP3K80.36032744
126CHUK0.35636385
127NEK90.34818737
128NEK20.33283026
129TAOK20.32488314
130CSNK1E0.31134289
131GRK10.30691448
132PRKCG0.29147601
133ERBB40.28559430
134PINK10.28039988
135MAPKAPK50.26830090
136AKT20.24872516
137PKN10.24306783

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.00226082
2Oxidative phosphorylation_Homo sapiens_hsa001904.14250443
3Parkinsons disease_Homo sapiens_hsa050123.75137566
4Proteasome_Homo sapiens_hsa030503.72853297
5RNA polymerase_Homo sapiens_hsa030203.31865174
6Huntingtons disease_Homo sapiens_hsa050162.78731827
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.63042563
8Alzheimers disease_Homo sapiens_hsa050102.58452966
9DNA replication_Homo sapiens_hsa030302.54810182
10Protein export_Homo sapiens_hsa030602.41869253
11Pyrimidine metabolism_Homo sapiens_hsa002402.41715029
12Spliceosome_Homo sapiens_hsa030402.11323254
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10484598
14Mismatch repair_Homo sapiens_hsa034302.09590438
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79206471
16Sulfur relay system_Homo sapiens_hsa041221.75589080
17Homologous recombination_Homo sapiens_hsa034401.71018020
18Base excision repair_Homo sapiens_hsa034101.62764833
19Nucleotide excision repair_Homo sapiens_hsa034201.53940546
20Folate biosynthesis_Homo sapiens_hsa007901.41566933
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35563801
22Cardiac muscle contraction_Homo sapiens_hsa042601.23508328
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23159989
24One carbon pool by folate_Homo sapiens_hsa006701.18392494
25RNA transport_Homo sapiens_hsa030131.13662625
26Glutathione metabolism_Homo sapiens_hsa004801.12276784
27Purine metabolism_Homo sapiens_hsa002301.07740903
28RNA degradation_Homo sapiens_hsa030181.07571905
29Fatty acid elongation_Homo sapiens_hsa000621.05915702
30Basal transcription factors_Homo sapiens_hsa030221.02588444
31Fanconi anemia pathway_Homo sapiens_hsa034601.00230188
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99386254
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97460405
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93837024
35Drug metabolism - other enzymes_Homo sapiens_hsa009830.93716444
36Sulfur metabolism_Homo sapiens_hsa009200.90948239
37p53 signaling pathway_Homo sapiens_hsa041150.88759406
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87754828
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85883858
40Propanoate metabolism_Homo sapiens_hsa006400.83180480
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81600931
42Chemical carcinogenesis_Homo sapiens_hsa052040.81288950
43Steroid biosynthesis_Homo sapiens_hsa001000.78040178
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77658351
45Arachidonic acid metabolism_Homo sapiens_hsa005900.76605473
46Cell cycle_Homo sapiens_hsa041100.71914209
47Pentose phosphate pathway_Homo sapiens_hsa000300.71904177
48Collecting duct acid secretion_Homo sapiens_hsa049660.71407651
49Systemic lupus erythematosus_Homo sapiens_hsa053220.71313599
50Metabolic pathways_Homo sapiens_hsa011000.68663410
51Epstein-Barr virus infection_Homo sapiens_hsa051690.68543439
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66592072
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65581944
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.59927990
55Biosynthesis of amino acids_Homo sapiens_hsa012300.58502291
56Legionellosis_Homo sapiens_hsa051340.58176031
57Non-homologous end-joining_Homo sapiens_hsa034500.57834571
58Herpes simplex infection_Homo sapiens_hsa051680.57370922
59Allograft rejection_Homo sapiens_hsa053300.57335471
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56848996
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.56790382
62Linoleic acid metabolism_Homo sapiens_hsa005910.55621718
63Graft-versus-host disease_Homo sapiens_hsa053320.53431489
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53111690
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52998063
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.52289848
67Asthma_Homo sapiens_hsa053100.51063042
68Phototransduction_Homo sapiens_hsa047440.48014130
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47677822
70Hematopoietic cell lineage_Homo sapiens_hsa046400.47606674
71Vitamin B6 metabolism_Homo sapiens_hsa007500.47164862
72Primary immunodeficiency_Homo sapiens_hsa053400.46843587
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46515487
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.44426213
75Antigen processing and presentation_Homo sapiens_hsa046120.43281643
76Tryptophan metabolism_Homo sapiens_hsa003800.43209209
77Tyrosine metabolism_Homo sapiens_hsa003500.42475894
78Phenylalanine metabolism_Homo sapiens_hsa003600.40407608
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39173023
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.38906543
81Butanoate metabolism_Homo sapiens_hsa006500.37937714
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37700914
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37665012
84Measles_Homo sapiens_hsa051620.37460258
85Retinol metabolism_Homo sapiens_hsa008300.37260220
86Apoptosis_Homo sapiens_hsa042100.37235390
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37100820
88Galactose metabolism_Homo sapiens_hsa000520.36749808
89Peroxisome_Homo sapiens_hsa041460.36368936
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35865734
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.34609527
92Leishmaniasis_Homo sapiens_hsa051400.34491470
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34323273
94Other glycan degradation_Homo sapiens_hsa005110.33197567
95mRNA surveillance pathway_Homo sapiens_hsa030150.33152159
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32842815
97Selenocompound metabolism_Homo sapiens_hsa004500.31673321
98Autoimmune thyroid disease_Homo sapiens_hsa053200.31476462
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30728472
100Pertussis_Homo sapiens_hsa051330.29897873
101Malaria_Homo sapiens_hsa051440.29039284
102Vitamin digestion and absorption_Homo sapiens_hsa049770.28546201
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28423774
104Rheumatoid arthritis_Homo sapiens_hsa053230.28410372
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28384474
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28245476
107Carbon metabolism_Homo sapiens_hsa012000.27989287
108Arginine and proline metabolism_Homo sapiens_hsa003300.27854651
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27571800
110Fat digestion and absorption_Homo sapiens_hsa049750.27218597
111Alcoholism_Homo sapiens_hsa050340.26552069
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26204872
113Fatty acid metabolism_Homo sapiens_hsa012120.24616440
114beta-Alanine metabolism_Homo sapiens_hsa004100.24202837
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23961865
116Regulation of autophagy_Homo sapiens_hsa041400.23761619
117Nitrogen metabolism_Homo sapiens_hsa009100.22874852
118Fatty acid degradation_Homo sapiens_hsa000710.22741909
119Vibrio cholerae infection_Homo sapiens_hsa051100.22627111
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21793339
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19111565
122Influenza A_Homo sapiens_hsa051640.18321668
123Fructose and mannose metabolism_Homo sapiens_hsa000510.17262271
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17079740
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.16524572
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15381824
127Pyruvate metabolism_Homo sapiens_hsa006200.15212324
128N-Glycan biosynthesis_Homo sapiens_hsa005100.15061535
129Caffeine metabolism_Homo sapiens_hsa002320.14949356
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14832342

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