MRPL53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.29949707
2ATP synthesis coupled proton transport (GO:0015986)8.06704629
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.06704629
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.00820327
5respiratory electron transport chain (GO:0022904)7.02533088
6electron transport chain (GO:0022900)6.85897686
7chaperone-mediated protein transport (GO:0072321)5.71421938
8protein complex biogenesis (GO:0070271)5.24694840
9protein neddylation (GO:0045116)5.18628137
10maturation of SSU-rRNA (GO:0030490)5.18584634
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.11459768
12NADH dehydrogenase complex assembly (GO:0010257)5.11459768
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.11459768
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.86940715
15mitochondrial respiratory chain complex assembly (GO:0033108)4.82814127
16proteasome assembly (GO:0043248)4.74247263
17rRNA modification (GO:0000154)4.54652097
18ribosomal small subunit biogenesis (GO:0042274)4.49823252
19axon ensheathment in central nervous system (GO:0032291)4.48652355
20central nervous system myelination (GO:0022010)4.48652355
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.37587430
22hydrogen ion transmembrane transport (GO:1902600)4.35174721
23ATP biosynthetic process (GO:0006754)4.34985898
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.34677879
25GTP biosynthetic process (GO:0006183)4.33599812
26regulation of mitochondrial translation (GO:0070129)4.33052811
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.31186218
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.30299926
29respiratory chain complex IV assembly (GO:0008535)4.27440705
30base-excision repair, AP site formation (GO:0006285)4.24493334
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.21806143
32protein targeting to mitochondrion (GO:0006626)4.13165324
33viral transcription (GO:0019083)4.00721976
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.97222958
35termination of RNA polymerase III transcription (GO:0006386)3.97222958
36establishment of protein localization to mitochondrion (GO:0072655)3.96914416
37DNA deamination (GO:0045006)3.95544469
38cotranslational protein targeting to membrane (GO:0006613)3.92686102
39translational termination (GO:0006415)3.90598882
40fatty acid elongation (GO:0030497)3.89796584
41proton transport (GO:0015992)3.88087752
42protein targeting to ER (GO:0045047)3.83914006
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83081545
44hydrogen transport (GO:0006818)3.79546121
45oxidative phosphorylation (GO:0006119)3.77630839
46cullin deneddylation (GO:0010388)3.76012451
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.75746851
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.75540676
49protein localization to mitochondrion (GO:0070585)3.73632409
50ubiquinone biosynthetic process (GO:0006744)3.73564107
51quinone biosynthetic process (GO:1901663)3.73564107
527-methylguanosine mRNA capping (GO:0006370)3.72128020
53protein localization to endoplasmic reticulum (GO:0070972)3.71515652
54protein targeting to membrane (GO:0006612)3.69874350
55protein complex disassembly (GO:0043241)3.69210808
56cytochrome complex assembly (GO:0017004)3.67555019
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65749772
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64096711
59peptidyl-histidine modification (GO:0018202)3.63731887
60pseudouridine synthesis (GO:0001522)3.62991833
61regulation of cellular amino acid metabolic process (GO:0006521)3.62463078
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62393732
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62393732
64UTP biosynthetic process (GO:0006228)3.61581509
657-methylguanosine RNA capping (GO:0009452)3.61509606
66RNA capping (GO:0036260)3.61509606
67inner mitochondrial membrane organization (GO:0007007)3.59610774
68deoxyribonucleotide catabolic process (GO:0009264)3.56048550
69pyrimidine nucleotide catabolic process (GO:0006244)3.55856606
70guanosine-containing compound biosynthetic process (GO:1901070)3.53993519
71protein deneddylation (GO:0000338)3.52929667
72ribosomal large subunit biogenesis (GO:0042273)3.51980056
73ubiquinone metabolic process (GO:0006743)3.51808446
74translation (GO:0006412)3.51619565
75macromolecular complex disassembly (GO:0032984)3.50553401
76ribosomal small subunit assembly (GO:0000028)3.49673592
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.49359162
78mitochondrial transport (GO:0006839)3.45861128
79nucleoside triphosphate biosynthetic process (GO:0009142)3.41975740
80rRNA methylation (GO:0031167)3.41950527
81deoxyribose phosphate catabolic process (GO:0046386)3.41559752
82translational elongation (GO:0006414)3.40273702
83intracellular protein transmembrane import (GO:0044743)3.38677302
84negative regulation of ligase activity (GO:0051352)3.37839136
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37839136
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28762832
87ribonucleoprotein complex biogenesis (GO:0022613)3.24307852
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22968793
89UTP metabolic process (GO:0046051)3.19664514
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19285958
91mannosylation (GO:0097502)3.18343200
92GDP-mannose metabolic process (GO:0019673)3.17332788
93amino acid salvage (GO:0043102)3.16930346
94L-methionine salvage (GO:0071267)3.16930346
95L-methionine biosynthetic process (GO:0071265)3.16930346
96nucleoside diphosphate phosphorylation (GO:0006165)3.16100800
97protein-cofactor linkage (GO:0018065)3.15933352
98viral life cycle (GO:0019058)3.15733114
99cellular protein complex disassembly (GO:0043624)3.13728504
100nuclear-transcribed mRNA catabolic process (GO:0000956)3.13012685
101deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11835048
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10913324
103aerobic respiration (GO:0009060)3.10575587
104signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09613506
105intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09613506
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07516584
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05876693
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05876693
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05876693
110deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.05336333
1112-deoxyribonucleotide metabolic process (GO:0009394)3.03676488
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02396917
113rRNA processing (GO:0006364)3.01668396
114ATP hydrolysis coupled proton transport (GO:0015991)3.01064385
115energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.01064385
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00989297
117cholesterol biosynthetic process (GO:0006695)2.99915832
118signal transduction involved in DNA damage checkpoint (GO:0072422)2.99358335
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99358335
120iron-sulfur cluster assembly (GO:0016226)2.97627931
121metallo-sulfur cluster assembly (GO:0031163)2.97627931
122GPI anchor biosynthetic process (GO:0006506)2.97120298
123cellular component biogenesis (GO:0044085)2.97076376
124translational initiation (GO:0006413)2.95967221
125signal transduction involved in cell cycle checkpoint (GO:0072395)2.94963976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.53410351
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.17080321
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.48405052
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.29218645
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.03584118
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80916472
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.69560470
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.68355313
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.59577984
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.31943040
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.27375598
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13944052
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99416211
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.81278717
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.78705095
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.60143223
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50441642
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42772554
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36927293
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.24870283
21* DCP1A_22483619_ChIP-Seq_HELA_Human2.24553115
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.08240226
23* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.07269068
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07124441
25* VDR_23849224_ChIP-Seq_CD4+_Human2.02265860
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93859608
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86325380
28ELK1_19687146_ChIP-ChIP_HELA_Human1.78879500
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75806279
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75286268
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73677880
32VDR_22108803_ChIP-Seq_LS180_Human1.72317727
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.71566825
34* XRN2_22483619_ChIP-Seq_HELA_Human1.71332166
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.68764849
36FOXP3_21729870_ChIP-Seq_TREG_Human1.64430993
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59057793
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56971864
39GABP_19822575_ChIP-Seq_HepG2_Human1.54846382
40* TTF2_22483619_ChIP-Seq_HELA_Human1.48308596
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44604938
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43176358
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40401599
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36598720
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35984684
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33823368
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28945852
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28652369
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28370297
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27910032
51BCL6_27268052_Chip-Seq_Bcells_Human1.27140235
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26019450
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24975235
54* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24514211
55FOXP1_21924763_ChIP-Seq_HESCs_Human1.23881113
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23860788
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22975459
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22923960
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.22261802
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21924669
61CIITA_25753668_ChIP-Seq_RAJI_Human1.19859898
62KDM5A_27292631_Chip-Seq_BREAST_Human1.18034266
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15919030
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.15464624
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13350665
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12980013
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12693057
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11036075
69* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10502081
70IRF1_19129219_ChIP-ChIP_H3396_Human1.10110970
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08633590
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08027039
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07581414
74VDR_21846776_ChIP-Seq_THP-1_Human1.07219207
75* CTCF_26484167_Chip-Seq_Bcells_Mouse1.07152906
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04694267
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03129920
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02360318
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01191554
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99556561
81E2F1_20622854_ChIP-Seq_HELA_Human0.99546187
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98905982
83STAT1_20625510_ChIP-Seq_HELA_Human0.98357820
84MYC_18940864_ChIP-ChIP_HL60_Human0.98230313
85P68_20966046_ChIP-Seq_HELA_Human0.97579029
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97564154
87E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97504803
88BCOR_27268052_Chip-Seq_Bcells_Human0.96789817
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96292079
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93767534
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92536961
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91768921
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91029416
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.90088562
95HTT_18923047_ChIP-ChIP_STHdh_Human0.89508269
96NANOG_20526341_ChIP-Seq_ESCs_Human0.88208295
97MAF_26560356_Chip-Seq_TH2_Human0.86219544
98SA1_27219007_Chip-Seq_Bcells_Human0.86189195
99PHF8_20622854_ChIP-Seq_HELA_Human0.85733663
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85241455
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84907818
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84901533
103* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82327927
104* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82110176
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80537265
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80056653
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.79822062
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79606154
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78677701
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78614601
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78341392
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78232164
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78001329
114NCOR_22424771_ChIP-Seq_293T_Human0.75744256
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75173292
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74890488
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74714102
118TAF15_26573619_Chip-Seq_HEK293_Human0.74310853
119FUS_26573619_Chip-Seq_HEK293_Human0.73686179
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73561699
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72405384
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71911299
123CTCF_20526341_ChIP-Seq_ESCs_Human0.71864931
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.71672090
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70598476
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.70059754
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.66111469
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.65877528
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65833289
130CBX2_27304074_Chip-Seq_ESCs_Mouse0.65456731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.88050716
2MP0001529_abnormal_vocalization3.66935009
3MP0003880_abnormal_central_pattern3.20842070
4MP0009379_abnormal_foot_pigmentation3.15856642
5MP0006036_abnormal_mitochondrial_physio3.01828797
6MP0001905_abnormal_dopamine_level2.95286541
7MP0002837_dystrophic_cardiac_calcinosis2.65630221
8MP0003646_muscle_fatigue2.58024702
9MP0003136_yellow_coat_color2.45238018
10MP0006035_abnormal_mitochondrial_morpho2.43528140
11MP0000749_muscle_degeneration2.38281779
12MP0003011_delayed_dark_adaptation2.20764139
13MP0006276_abnormal_autonomic_nervous2.19489612
14MP0004142_abnormal_muscle_tone2.17769513
15MP0002736_abnormal_nociception_after2.07092450
16MP0003718_maternal_effect1.96474875
17MP0003186_abnormal_redox_activity1.93274055
18MP0003950_abnormal_plasma_membrane1.92251568
19MP0004036_abnormal_muscle_relaxation1.91314042
20MP0008260_abnormal_autophagy1.88770398
21MP0005451_abnormal_body_composition1.87047222
22MP0002653_abnormal_ependyma_morphology1.74923438
23MP0008058_abnormal_DNA_repair1.74349868
24MP0002148_abnormal_hypersensitivity_rea1.73807043
25MP0005174_abnormal_tail_pigmentation1.72356820
26MP0004043_abnormal_pH_regulation1.70851768
27MP0000920_abnormal_myelination1.70612399
28MP0005671_abnormal_response_to1.68610691
29MP0001727_abnormal_embryo_implantation1.66476132
30MP0004145_abnormal_muscle_electrophysio1.66395942
31MP0003786_premature_aging1.66041319
32MP0001986_abnormal_taste_sensitivity1.63195495
33MP0008932_abnormal_embryonic_tissue1.62932965
34MP0005075_abnormal_melanosome_morpholog1.62027272
35MP0000372_irregular_coat_pigmentation1.58243812
36MP0000750_abnormal_muscle_regeneration1.57803428
37MP0001968_abnormal_touch/_nociception1.51839390
38MP0002876_abnormal_thyroid_physiology1.51534482
39MP0002277_abnormal_respiratory_mucosa1.48984971
40MP0006292_abnormal_olfactory_placode1.47707238
41MP0005084_abnormal_gallbladder_morpholo1.46157871
42MP0005171_absent_coat_pigmentation1.44659637
43MP0002638_abnormal_pupillary_reflex1.44650608
44MP0005408_hypopigmentation1.43330781
45MP0004147_increased_porphyrin_level1.43158374
46MP0003195_calcinosis1.42981313
47MP0002272_abnormal_nervous_system1.42892014
48MP0009785_altered_susceptibility_to1.42237523
49MP0000343_altered_response_to1.32245994
50MP0002095_abnormal_skin_pigmentation1.31326173
51MP0003315_abnormal_perineum_morphology1.30734966
52MP0004215_abnormal_myocardial_fiber1.28727576
53MP0000566_synostosis1.25592625
54MP0009333_abnormal_splenocyte_physiolog1.24096772
55MP0002734_abnormal_mechanical_nocicepti1.20465352
56MP0005409_darkened_coat_color1.20380646
57MP0000751_myopathy1.18840207
58MP0009697_abnormal_copulation1.18717112
59MP0008789_abnormal_olfactory_epithelium1.18478617
60MP0005330_cardiomyopathy1.17890778
61MP0001919_abnormal_reproductive_system1.17809923
62MP0005410_abnormal_fertilization1.15395255
63MP0006072_abnormal_retinal_apoptosis1.14492441
64MP0002160_abnormal_reproductive_system1.14415067
65MP0005389_reproductive_system_phenotype1.13573923
66MP0004381_abnormal_hair_follicle1.12719180
67MP0008875_abnormal_xenobiotic_pharmacok1.12552068
68MP0001485_abnormal_pinna_reflex1.11930317
69MP0000747_muscle_weakness1.10866430
70MP0005379_endocrine/exocrine_gland_phen1.10862317
71MP0001756_abnormal_urination1.09540036
72MP0010386_abnormal_urinary_bladder1.08647402
73MP0004957_abnormal_blastocyst_morpholog1.08034701
74MP0003693_abnormal_embryo_hatching1.07742003
75MP0005083_abnormal_biliary_tract1.07215150
76MP0004133_heterotaxia1.06062717
77MP0003137_abnormal_impulse_conducting1.06034876
78MP0005645_abnormal_hypothalamus_physiol1.02725559
79MP0004742_abnormal_vestibular_system1.02666151
80MP0002064_seizures1.02127939
81MP0002822_catalepsy1.01508768
82MP0009840_abnormal_foam_cell1.00871641
83MP0009764_decreased_sensitivity_to0.99992401
84MP0005332_abnormal_amino_acid0.99159513
85MP0000685_abnormal_immune_system0.99020962
86MP0004084_abnormal_cardiac_muscle0.98437373
87MP0005646_abnormal_pituitary_gland0.98425424
88MP0008995_early_reproductive_senescence0.98203007
89MP0005058_abnormal_lysosome_morphology0.97886289
90MP0000762_abnormal_tongue_morphology0.97366406
91MP0000026_abnormal_inner_ear0.97063861
92MP0005551_abnormal_eye_electrophysiolog0.96946104
93MP0001970_abnormal_pain_threshold0.96380975
94MP0001188_hyperpigmentation0.95658861
95MP0005423_abnormal_somatic_nervous0.95551690
96MP0009046_muscle_twitch0.95491947
97MP0003938_abnormal_ear_development0.94708843
98MP0002132_abnormal_respiratory_system0.93888912
99MP0005584_abnormal_enzyme/coenzyme_acti0.93878981
100MP0001963_abnormal_hearing_physiology0.93554864
101MP0001440_abnormal_grooming_behavior0.93019454
102MP0005319_abnormal_enzyme/_coenzyme0.92919256
103MP0002139_abnormal_hepatobiliary_system0.91604779
104MP0005253_abnormal_eye_physiology0.91404000
105MP0002229_neurodegeneration0.91227309
106MP0001664_abnormal_digestion0.91164876
107MP0003122_maternal_imprinting0.90956377
108MP0008872_abnormal_physiological_respon0.90919417
109MP0002295_abnormal_pulmonary_circulatio0.89780354
110MP0004019_abnormal_vitamin_homeostasis0.89234194
111MP0008007_abnormal_cellular_replicative0.88670918
112MP0002751_abnormal_autonomic_nervous0.88588200
113MP0005636_abnormal_mineral_homeostasis0.87259544
114MP0002163_abnormal_gland_morphology0.86320853
115MP0005386_behavior/neurological_phenoty0.85812787
116MP0004924_abnormal_behavior0.85812787
117MP0001542_abnormal_bone_strength0.85565520
118MP0008469_abnormal_protein_level0.85302646
119MP0004270_analgesia0.83956448
120MP0004484_altered_response_of0.82896970
121MP0004782_abnormal_surfactant_physiolog0.82368482
122MP0010030_abnormal_orbit_morphology0.82295488
123MP0005670_abnormal_white_adipose0.81522221
124MP0001764_abnormal_homeostasis0.81375704
125MP0002938_white_spotting0.80609063
126MP0009643_abnormal_urine_homeostasis0.80584133
127MP0009745_abnormal_behavioral_response0.79953630
128MP0005025_abnormal_response_to0.79167510
129MP0002106_abnormal_muscle_physiology0.78390582
130MP0005266_abnormal_metabolism0.78302123
131MP0005387_immune_system_phenotype0.77665551
132MP0001790_abnormal_immune_system0.77665551
133MP0000230_abnormal_systemic_arterial0.77437275
134MP0002102_abnormal_ear_morphology0.76204258
135MP0002067_abnormal_sensory_capabilities0.75958839
136MP0000538_abnormal_urinary_bladder0.75663703
137MP0003123_paternal_imprinting0.74746284
138MP0002752_abnormal_somatic_nervous0.74240590
139MP0002693_abnormal_pancreas_physiology0.73887567
140MP0002733_abnormal_thermal_nociception0.73730832
141MP0000358_abnormal_cell_content/0.73217709
142MP0001984_abnormal_olfaction0.72802287
143MP0005620_abnormal_muscle_contractility0.72448821
144MP0000778_abnormal_nervous_system0.72265349
145MP0002210_abnormal_sex_determination0.72120904
146MP0001835_abnormal_antigen_presentation0.71756596
147MP0002723_abnormal_immune_serum0.71642654
148MP0005000_abnormal_immune_tolerance0.70497336
149MP0001800_abnormal_humoral_immune0.70043343
150MP0001845_abnormal_inflammatory_respons0.69371204
151MP0001944_abnormal_pancreas_morphology0.69046175
152MP0003111_abnormal_nucleus_morphology0.64566671
153MP0002452_abnormal_antigen_presenting0.63738868
154MP0002234_abnormal_pharynx_morphology0.62111735

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.82697280
2Abnormal mitochondria in muscle tissue (HP:0008316)6.12100768
3Mitochondrial inheritance (HP:0001427)5.93105389
4Acute encephalopathy (HP:0006846)5.76682773
5Progressive macrocephaly (HP:0004481)5.53301684
6Hepatocellular necrosis (HP:0001404)5.22378258
7Increased CSF lactate (HP:0002490)5.14525771
8Hepatic necrosis (HP:0002605)4.80230655
9Increased hepatocellular lipid droplets (HP:0006565)4.52029614
10Abnormality of glycolysis (HP:0004366)4.50260737
11Increased serum pyruvate (HP:0003542)4.50260737
12Cerebral edema (HP:0002181)4.32890867
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.24822364
14Lipid accumulation in hepatocytes (HP:0006561)4.21697377
15Renal Fanconi syndrome (HP:0001994)4.20700891
163-Methylglutaconic aciduria (HP:0003535)4.05127476
17Respiratory failure (HP:0002878)3.78076137
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.72449945
19Leukodystrophy (HP:0002415)3.71628631
20Exercise intolerance (HP:0003546)3.68374753
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66465270
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66465270
23Increased serum lactate (HP:0002151)3.63967370
24Lactic acidosis (HP:0003128)3.63507146
25Optic disc pallor (HP:0000543)3.49552406
26Abnormality of cells of the erythroid lineage (HP:0012130)3.46678742
27Increased intramyocellular lipid droplets (HP:0012240)3.44306178
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.16123115
29Increased muscle lipid content (HP:0009058)3.05950000
30Microvesicular hepatic steatosis (HP:0001414)3.01961021
31Exertional dyspnea (HP:0002875)2.83327826
32Cerebral hypomyelination (HP:0006808)2.79109388
33Abnormal number of erythroid precursors (HP:0012131)2.71465577
34Abnormality of renal resorption (HP:0011038)2.67919841
35Reduced antithrombin III activity (HP:0001976)2.65878033
36Lethargy (HP:0001254)2.57499765
37Abnormal protein glycosylation (HP:0012346)2.57432267
38Abnormal glycosylation (HP:0012345)2.57432267
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57432267
40Abnormal protein N-linked glycosylation (HP:0012347)2.57432267
41Neuroendocrine neoplasm (HP:0100634)2.55960448
42CNS demyelination (HP:0007305)2.53677366
43Sensory axonal neuropathy (HP:0003390)2.53155042
44Pheochromocytoma (HP:0002666)2.52440378
45Respiratory difficulties (HP:0002880)2.52429163
46Macrocytic anemia (HP:0001972)2.48673185
47Glycosuria (HP:0003076)2.47519225
48Abnormality of urine glucose concentration (HP:0011016)2.47519225
49Parakeratosis (HP:0001036)2.37982571
50Congenital ichthyosiform erythroderma (HP:0007431)2.37552131
51Stenosis of the external auditory canal (HP:0000402)2.29526786
52Muscle hypertrophy of the lower extremities (HP:0008968)2.28718570
53Congenital, generalized hypertrichosis (HP:0004540)2.27890782
54X-linked dominant inheritance (HP:0001423)2.27047481
55Spastic paraparesis (HP:0002313)2.21870487
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21798647
57Dicarboxylic aciduria (HP:0003215)2.21798647
58Emotional lability (HP:0000712)2.17197008
59Pancytopenia (HP:0001876)2.12225400
60Amniotic constriction ring (HP:0009775)2.11424611
61Abnormality of placental membranes (HP:0011409)2.11424611
62Hyperphosphaturia (HP:0003109)2.10524657
63Calf muscle hypertrophy (HP:0008981)2.08161835
64Rib fusion (HP:0000902)2.05530625
65Absent thumb (HP:0009777)2.04433583
66Type 2 muscle fiber atrophy (HP:0003554)2.03300188
67Muscle fiber atrophy (HP:0100295)2.01876810
68Molar tooth sign on MRI (HP:0002419)2.00755038
69Abnormality of midbrain morphology (HP:0002418)2.00755038
70Myokymia (HP:0002411)1.99397608
71Palpitations (HP:0001962)1.98792043
72Oral leukoplakia (HP:0002745)1.97722466
73Type I transferrin isoform profile (HP:0003642)1.95201066
74Methylmalonic aciduria (HP:0012120)1.93907669
75Rough bone trabeculation (HP:0100670)1.86375327
76CNS hypomyelination (HP:0003429)1.86318356
77Rimmed vacuoles (HP:0003805)1.84778970
78Ragged-red muscle fibers (HP:0003200)1.82809817
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82671238
80Brushfield spots (HP:0001088)1.82658444
81Degeneration of the lateral corticospinal tracts (HP:0002314)1.82622436
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82622436
83Congenital malformation of the right heart (HP:0011723)1.81038153
84Double outlet right ventricle (HP:0001719)1.81038153
85Opisthotonus (HP:0002179)1.80926157
86Delusions (HP:0000746)1.79232471
87Reticulocytopenia (HP:0001896)1.78867271
88Abnormal urine phosphate concentration (HP:0012599)1.76429345
89Vomiting (HP:0002013)1.76360583
90Methylmalonic acidemia (HP:0002912)1.74524551
91Progressive external ophthalmoplegia (HP:0000590)1.74392048
92Progressive microcephaly (HP:0000253)1.73826737
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72478321
94Congenital stationary night blindness (HP:0007642)1.72457147
95Pallor (HP:0000980)1.71806669
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71692882
97Partial duplication of thumb phalanx (HP:0009944)1.70790515
98Ketosis (HP:0001946)1.70614778
99Microretrognathia (HP:0000308)1.68998201
100Split foot (HP:0001839)1.66954616
101Muscle fiber splitting (HP:0003555)1.66126515
102Nausea (HP:0002018)1.65976919
103Hypoplastic left heart (HP:0004383)1.65585385
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65581100
105Cerebral hemorrhage (HP:0001342)1.65069649
106Pancreatic cysts (HP:0001737)1.64398086
107Abnormal hemoglobin (HP:0011902)1.63906529
108Medial flaring of the eyebrow (HP:0010747)1.63193156
109Progressive muscle weakness (HP:0003323)1.62407917
110Pancreatic fibrosis (HP:0100732)1.62254712
111Rhabdomyolysis (HP:0003201)1.61815928
112Testicular atrophy (HP:0000029)1.61041713
113Abnormal trabecular bone morphology (HP:0100671)1.59927537
114Abnormal pupillary function (HP:0007686)1.59299123
115Abnormality of fatty-acid metabolism (HP:0004359)1.58724420
116Poor suck (HP:0002033)1.57208270
117Blindness (HP:0000618)1.55985441
118Hypoplastic heart (HP:0001961)1.55976810
119Prolonged neonatal jaundice (HP:0006579)1.54509567
120Aplasia/hypoplasia of the uterus (HP:0008684)1.54057975
121Gliosis (HP:0002171)1.53876711
122Cleft eyelid (HP:0000625)1.53356230
123Generalized aminoaciduria (HP:0002909)1.52787397
124Ileus (HP:0002595)1.52708217
125Nephronophthisis (HP:0000090)1.52643130
126Hyperglycinemia (HP:0002154)1.52538875
127Metabolic acidosis (HP:0001942)1.52145319
128Renal tubular dysfunction (HP:0000124)1.51922370
129Hypothermia (HP:0002045)1.51003450
130Nasolacrimal duct obstruction (HP:0000579)1.50821868
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.50233472
132Abnormality of alanine metabolism (HP:0010916)1.50233472
133Hyperalaninemia (HP:0003348)1.50233472
134Aplastic anemia (HP:0001915)1.49407400
135Partial duplication of the phalanx of hand (HP:0009999)1.48683580
136Congenital primary aphakia (HP:0007707)1.47839868
137Paralysis (HP:0003470)1.46061881
138Premature graying of hair (HP:0002216)1.45872614
139True hermaphroditism (HP:0010459)1.45557361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.19912448
2BUB14.10022689
3NME23.81328482
4ARAF3.32058964
5STK393.16508605
6PBK2.95091209
7STK162.89733494
8NME12.88753924
9BRAF2.35961031
10EIF2AK12.13831731
11OXSR12.08171221
12WNK42.03215370
13LIMK11.99714746
14MAP4K21.97333797
15BCKDK1.96370668
16OBSCN1.95661781
17MYLK1.86233633
18MST41.84002579
19VRK11.83871749
20PIM21.82728698
21CASK1.77200334
22TESK21.77198775
23MAPK151.70169970
24BCR1.67877094
25TLK11.53554980
26MAP3K121.48349289
27EIF2AK31.48210229
28TXK1.46505823
29TNIK1.38047257
30ABL21.36576205
31DYRK21.29887155
32CDK191.29789379
33MAPKAPK51.29436043
34GRK11.24206677
35CSNK1G31.23364510
36MAP2K21.20033604
37SRPK11.17527252
38IKBKB1.17073041
39PLK41.16883626
40NUAK11.11635592
41GRK51.10706389
42CAMK2D1.10620447
43LRRK21.09270533
44TRIM281.08400036
45WEE11.06694675
46CAMK2B1.06687693
47MUSK1.05038679
48PKN10.99089489
49GRK70.97629794
50IRAK10.96962687
51PINK10.96540996
52TESK10.95710971
53AURKA0.93548910
54PIK3CA0.90170337
55CAMK2G0.89580850
56DAPK10.85684418
57MAP3K110.85667171
58EPHB20.85319588
59ADRBK20.84122325
60CSNK1G10.82730595
61MAP2K70.82645611
62DAPK30.82565472
63RPS6KA50.81996877
64CDK80.80400498
65MAPKAPK30.79902625
66CDC70.79856191
67IRAK20.72218540
68TAOK20.72137578
69BMPR1B0.71933005
70BMPR20.71619970
71PAK10.70350950
72ZAK0.68125309
73ILK0.67688843
74CDK140.66634029
75NEK10.66599451
76CSNK1A1L0.65623693
77AURKB0.65599483
78NEK60.65039338
79DYRK30.64995734
80UHMK10.64472762
81CAMK2A0.64087114
82ROCK20.63759383
83MET0.61351906
84MST1R0.61321809
85TAF10.60940541
86BRSK20.59661566
87TBK10.59259411
88PRKCI0.58513652
89PDK20.58062368
90MAP4K10.57982479
91IRAK30.56646706
92PNCK0.56035350
93CSNK1G20.54500747
94PRKCE0.53842964
95PLK20.53604454
96CCNB10.53557189
97INSRR0.52868847
98PDK30.51822863
99PDK40.51822863
100MAP2K60.51581693
101TIE10.49792030
102MOS0.49061082
103PASK0.48394929
104CSNK2A10.48253417
105PRKCG0.48048485
106PRKCD0.47864117
107STK38L0.45390628
108PLK30.45238527
109CDK180.44901200
110ADRBK10.44405135
111PRKACA0.44383522
112WNK30.44012251
113CAMKK20.42881495
114MKNK10.42150814
115MAPK130.41934950
116CDK150.41566999
117STK40.40647043
118CSNK2A20.40369613
119RPS6KB20.40270871
120CDK11A0.39586151
121CHEK20.39156702
122IRAK40.39074234
123LYN0.38611236
124PAK40.37990925
125GRK60.37952425
126TSSK60.37549151
127ERBB40.35726711
128IKBKE0.34823240
129ITK0.34326293
130STK240.34119186
131PHKG20.33842100
132PHKG10.33842100
133PLK10.33802617
134CSNK1A10.32459091
135ATR0.32421104
136PRKCQ0.32375586
137AKT30.32286005
138KDR0.32049804
139BRSK10.31733542
140AKT20.31438634

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.76716026
2Parkinsons disease_Homo sapiens_hsa050124.87926240
3Ribosome_Homo sapiens_hsa030103.89915349
4Proteasome_Homo sapiens_hsa030503.73690840
5Alzheimers disease_Homo sapiens_hsa050103.58112377
6Huntingtons disease_Homo sapiens_hsa050163.48203436
7Protein export_Homo sapiens_hsa030603.06231960
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99172383
9RNA polymerase_Homo sapiens_hsa030202.83799848
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.68856030
11Cardiac muscle contraction_Homo sapiens_hsa042602.29714240
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07097775
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03086296
14Fatty acid elongation_Homo sapiens_hsa000621.99195301
15Sulfur metabolism_Homo sapiens_hsa009201.96416779
16Collecting duct acid secretion_Homo sapiens_hsa049661.70555461
17Pyrimidine metabolism_Homo sapiens_hsa002401.57168859
18Steroid biosynthesis_Homo sapiens_hsa001001.42382519
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39309638
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32128365
21Vibrio cholerae infection_Homo sapiens_hsa051101.18693030
22Pyruvate metabolism_Homo sapiens_hsa006201.16532868
23Glutathione metabolism_Homo sapiens_hsa004801.14441541
24Propanoate metabolism_Homo sapiens_hsa006401.11434312
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09165658
26Ether lipid metabolism_Homo sapiens_hsa005651.06991077
27Asthma_Homo sapiens_hsa053101.06327245
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04584475
29Metabolic pathways_Homo sapiens_hsa011001.03693412
30Linoleic acid metabolism_Homo sapiens_hsa005911.03242003
31Folate biosynthesis_Homo sapiens_hsa007901.02321254
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01876530
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00046815
34Purine metabolism_Homo sapiens_hsa002301.00038196
35Homologous recombination_Homo sapiens_hsa034400.99900420
36Sulfur relay system_Homo sapiens_hsa041220.95764776
37Vitamin B6 metabolism_Homo sapiens_hsa007500.94690131
38Nucleotide excision repair_Homo sapiens_hsa034200.94562567
39Basal transcription factors_Homo sapiens_hsa030220.94180573
40Butanoate metabolism_Homo sapiens_hsa006500.91406476
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90963998
42Peroxisome_Homo sapiens_hsa041460.90882809
43Regulation of autophagy_Homo sapiens_hsa041400.90660210
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89859526
45Arachidonic acid metabolism_Homo sapiens_hsa005900.89602165
46Allograft rejection_Homo sapiens_hsa053300.84314566
47Primary immunodeficiency_Homo sapiens_hsa053400.83630978
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83617443
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82589318
50Autoimmune thyroid disease_Homo sapiens_hsa053200.79926190
51Spliceosome_Homo sapiens_hsa030400.78026644
52Carbon metabolism_Homo sapiens_hsa012000.77757899
53Arginine and proline metabolism_Homo sapiens_hsa003300.76715429
54Chemical carcinogenesis_Homo sapiens_hsa052040.76659932
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75857541
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.75854575
57Tyrosine metabolism_Homo sapiens_hsa003500.75377162
58Type I diabetes mellitus_Homo sapiens_hsa049400.74491057
59One carbon pool by folate_Homo sapiens_hsa006700.72789433
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71400741
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.68248271
62Graft-versus-host disease_Homo sapiens_hsa053320.67875901
63Phenylalanine metabolism_Homo sapiens_hsa003600.67646121
64DNA replication_Homo sapiens_hsa030300.67199740
65Histidine metabolism_Homo sapiens_hsa003400.66589367
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65338971
67Sphingolipid metabolism_Homo sapiens_hsa006000.65275777
68Rheumatoid arthritis_Homo sapiens_hsa053230.64753111
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63686290
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62475668
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61618046
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.61057069
73Mismatch repair_Homo sapiens_hsa034300.59391406
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58116206
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56521965
76Fructose and mannose metabolism_Homo sapiens_hsa000510.55697889
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53344822
78N-Glycan biosynthesis_Homo sapiens_hsa005100.51821244
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.44998305
80Tryptophan metabolism_Homo sapiens_hsa003800.44724851
81RNA degradation_Homo sapiens_hsa030180.44668916
82RNA transport_Homo sapiens_hsa030130.44149621
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43906605
84Antigen processing and presentation_Homo sapiens_hsa046120.43760500
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42151269
86beta-Alanine metabolism_Homo sapiens_hsa004100.39820547
87Galactose metabolism_Homo sapiens_hsa000520.38754478
88Biosynthesis of amino acids_Homo sapiens_hsa012300.38392508
89Pentose phosphate pathway_Homo sapiens_hsa000300.38267927
90Synaptic vesicle cycle_Homo sapiens_hsa047210.35311375
91Nitrogen metabolism_Homo sapiens_hsa009100.33121162
92Base excision repair_Homo sapiens_hsa034100.32227492
93Serotonergic synapse_Homo sapiens_hsa047260.31998967
94Fat digestion and absorption_Homo sapiens_hsa049750.31703731
95Retinol metabolism_Homo sapiens_hsa008300.30315096
96Fatty acid metabolism_Homo sapiens_hsa012120.29702408
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28264851
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28190191
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26792629
100Fatty acid degradation_Homo sapiens_hsa000710.26211354
101Phagosome_Homo sapiens_hsa041450.25524240
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.24475286
103Alcoholism_Homo sapiens_hsa050340.21810671
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21643005
105Lysosome_Homo sapiens_hsa041420.21393436
106Selenocompound metabolism_Homo sapiens_hsa004500.21050491
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.21021276
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20382682
109Hematopoietic cell lineage_Homo sapiens_hsa046400.20109970
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.18717117
111Nicotine addiction_Homo sapiens_hsa050330.16427856
112Phototransduction_Homo sapiens_hsa047440.13842458
113Fanconi anemia pathway_Homo sapiens_hsa034600.11662814
114Taste transduction_Homo sapiens_hsa047420.11027091
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.10640921
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10544360
117GABAergic synapse_Homo sapiens_hsa047270.09633102
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.08962027
119Epstein-Barr virus infection_Homo sapiens_hsa051690.08490156
120Systemic lupus erythematosus_Homo sapiens_hsa053220.07872027
121Non-homologous end-joining_Homo sapiens_hsa034500.07604185
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05717218

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