Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 8.29949707 |
2 | ATP synthesis coupled proton transport (GO:0015986) | 8.06704629 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 8.06704629 |
4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 8.00820327 |
5 | respiratory electron transport chain (GO:0022904) | 7.02533088 |
6 | electron transport chain (GO:0022900) | 6.85897686 |
7 | chaperone-mediated protein transport (GO:0072321) | 5.71421938 |
8 | protein complex biogenesis (GO:0070271) | 5.24694840 |
9 | protein neddylation (GO:0045116) | 5.18628137 |
10 | maturation of SSU-rRNA (GO:0030490) | 5.18584634 |
11 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.11459768 |
12 | NADH dehydrogenase complex assembly (GO:0010257) | 5.11459768 |
13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.11459768 |
14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.86940715 |
15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.82814127 |
16 | proteasome assembly (GO:0043248) | 4.74247263 |
17 | rRNA modification (GO:0000154) | 4.54652097 |
18 | ribosomal small subunit biogenesis (GO:0042274) | 4.49823252 |
19 | central nervous system myelination (GO:0022010) | 4.48652355 |
20 | axon ensheathment in central nervous system (GO:0032291) | 4.48652355 |
21 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.37587430 |
22 | hydrogen ion transmembrane transport (GO:1902600) | 4.35174721 |
23 | ATP biosynthetic process (GO:0006754) | 4.34985898 |
24 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.34677879 |
25 | GTP biosynthetic process (GO:0006183) | 4.33599812 |
26 | regulation of mitochondrial translation (GO:0070129) | 4.33052811 |
27 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.31186218 |
28 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.30299926 |
29 | respiratory chain complex IV assembly (GO:0008535) | 4.27440705 |
30 | base-excision repair, AP site formation (GO:0006285) | 4.24493334 |
31 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.21806143 |
32 | protein targeting to mitochondrion (GO:0006626) | 4.13165324 |
33 | viral transcription (GO:0019083) | 4.00721976 |
34 | termination of RNA polymerase III transcription (GO:0006386) | 3.97222958 |
35 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.97222958 |
36 | establishment of protein localization to mitochondrion (GO:0072655) | 3.96914416 |
37 | DNA deamination (GO:0045006) | 3.95544469 |
38 | cotranslational protein targeting to membrane (GO:0006613) | 3.92686102 |
39 | translational termination (GO:0006415) | 3.90598882 |
40 | fatty acid elongation (GO:0030497) | 3.89796584 |
41 | proton transport (GO:0015992) | 3.88087752 |
42 | protein targeting to ER (GO:0045047) | 3.83914006 |
43 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.83081545 |
44 | hydrogen transport (GO:0006818) | 3.79546121 |
45 | oxidative phosphorylation (GO:0006119) | 3.77630839 |
46 | cullin deneddylation (GO:0010388) | 3.76012451 |
47 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.75746851 |
48 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.75540676 |
49 | protein localization to mitochondrion (GO:0070585) | 3.73632409 |
50 | ubiquinone biosynthetic process (GO:0006744) | 3.73564107 |
51 | quinone biosynthetic process (GO:1901663) | 3.73564107 |
52 | 7-methylguanosine mRNA capping (GO:0006370) | 3.72128020 |
53 | protein localization to endoplasmic reticulum (GO:0070972) | 3.71515652 |
54 | protein targeting to membrane (GO:0006612) | 3.69874350 |
55 | protein complex disassembly (GO:0043241) | 3.69210808 |
56 | cytochrome complex assembly (GO:0017004) | 3.67555019 |
57 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.65749772 |
58 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.64096711 |
59 | peptidyl-histidine modification (GO:0018202) | 3.63731887 |
60 | pseudouridine synthesis (GO:0001522) | 3.62991833 |
61 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.62463078 |
62 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.62393732 |
63 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.62393732 |
64 | UTP biosynthetic process (GO:0006228) | 3.61581509 |
65 | 7-methylguanosine RNA capping (GO:0009452) | 3.61509606 |
66 | RNA capping (GO:0036260) | 3.61509606 |
67 | inner mitochondrial membrane organization (GO:0007007) | 3.59610774 |
68 | deoxyribonucleotide catabolic process (GO:0009264) | 3.56048550 |
69 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.55856606 |
70 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.53993519 |
71 | protein deneddylation (GO:0000338) | 3.52929667 |
72 | ribosomal large subunit biogenesis (GO:0042273) | 3.51980056 |
73 | ubiquinone metabolic process (GO:0006743) | 3.51808446 |
74 | translation (GO:0006412) | 3.51619565 |
75 | macromolecular complex disassembly (GO:0032984) | 3.50553401 |
76 | ribosomal small subunit assembly (GO:0000028) | 3.49673592 |
77 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.49359162 |
78 | mitochondrial transport (GO:0006839) | 3.45861128 |
79 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.41975740 |
80 | rRNA methylation (GO:0031167) | 3.41950527 |
81 | deoxyribose phosphate catabolic process (GO:0046386) | 3.41559752 |
82 | translational elongation (GO:0006414) | 3.40273702 |
83 | intracellular protein transmembrane import (GO:0044743) | 3.38677302 |
84 | negative regulation of ligase activity (GO:0051352) | 3.37839136 |
85 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.37839136 |
86 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.28762832 |
87 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.24307852 |
88 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.22968793 |
89 | UTP metabolic process (GO:0046051) | 3.19664514 |
90 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.19285958 |
91 | mannosylation (GO:0097502) | 3.18343200 |
92 | GDP-mannose metabolic process (GO:0019673) | 3.17332788 |
93 | amino acid salvage (GO:0043102) | 3.16930346 |
94 | L-methionine salvage (GO:0071267) | 3.16930346 |
95 | L-methionine biosynthetic process (GO:0071265) | 3.16930346 |
96 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.16100800 |
97 | protein-cofactor linkage (GO:0018065) | 3.15933352 |
98 | viral life cycle (GO:0019058) | 3.15733114 |
99 | cellular protein complex disassembly (GO:0043624) | 3.13728504 |
100 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.13012685 |
101 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.11835048 |
102 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.10913324 |
103 | aerobic respiration (GO:0009060) | 3.10575587 |
104 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.09613506 |
105 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.09613506 |
106 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.07516584 |
107 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.05876693 |
108 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.05876693 |
109 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.05876693 |
110 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.05336333 |
111 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.03676488 |
112 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.02396917 |
113 | rRNA processing (GO:0006364) | 3.01668396 |
114 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.01064385 |
115 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.01064385 |
116 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.00989297 |
117 | cholesterol biosynthetic process (GO:0006695) | 2.99915832 |
118 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.99358335 |
119 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.99358335 |
120 | metallo-sulfur cluster assembly (GO:0031163) | 2.97627931 |
121 | iron-sulfur cluster assembly (GO:0016226) | 2.97627931 |
122 | GPI anchor biosynthetic process (GO:0006506) | 2.97120298 |
123 | cellular component biogenesis (GO:0044085) | 2.97076376 |
124 | translational initiation (GO:0006413) | 2.95967221 |
125 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.94963976 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.53410351 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.17080321 |
3 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.48405052 |
4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.29218645 |
5 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.03584118 |
6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.80916472 |
7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.69560470 |
8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.68355313 |
9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.59577984 |
10 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.31943040 |
11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.27375598 |
12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.13944052 |
13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.99416211 |
14 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.81278717 |
15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.78705095 |
16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.60143223 |
17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.50441642 |
18 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.42772554 |
19 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.36927293 |
20 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.24870283 |
21 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.24553115 |
22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.08240226 |
23 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.07269068 |
24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.07124441 |
25 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.02265860 |
26 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.93859608 |
27 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86325380 |
28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.78879500 |
29 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.75806279 |
30 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.75286268 |
31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.73677880 |
32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.72317727 |
33 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.71566825 |
34 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.71332166 |
35 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.68764849 |
36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.64430993 |
37 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59057793 |
38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.56971864 |
39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54846382 |
40 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.48308596 |
41 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.44604938 |
42 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.43176358 |
43 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.40401599 |
44 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.36598720 |
45 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.35984684 |
46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.33823368 |
47 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.28945852 |
48 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.28652369 |
49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28370297 |
50 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.27910032 |
51 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.27140235 |
52 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.26019450 |
53 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24975235 |
54 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24514211 |
55 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.23881113 |
56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.23860788 |
57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.22975459 |
58 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.22923960 |
59 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.22261802 |
60 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.21924669 |
61 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.19859898 |
62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18034266 |
63 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.15919030 |
64 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.15464624 |
65 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.13350665 |
66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12980013 |
67 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.12693057 |
68 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.11036075 |
69 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.10502081 |
70 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.10110970 |
71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08633590 |
72 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.08027039 |
73 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.07581414 |
74 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.07219207 |
75 | * CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.07152906 |
76 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.04694267 |
77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03129920 |
78 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.02360318 |
79 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.01191554 |
80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99556561 |
81 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.99546187 |
82 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.98905982 |
83 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.98357820 |
84 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.98230313 |
85 | P68_20966046_ChIP-Seq_HELA_Human | 0.97579029 |
86 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.97564154 |
87 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.97504803 |
88 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.96789817 |
89 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.96292079 |
90 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93767534 |
91 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92536961 |
92 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91768921 |
93 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91029416 |
94 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.90088562 |
95 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.89508269 |
96 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.88208295 |
97 | MAF_26560356_Chip-Seq_TH2_Human | 0.86219544 |
98 | SA1_27219007_Chip-Seq_Bcells_Human | 0.86189195 |
99 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.85733663 |
100 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.85241455 |
101 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.84907818 |
102 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.84901533 |
103 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.82327927 |
104 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.82110176 |
105 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.80537265 |
106 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.80056653 |
107 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.79822062 |
108 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.79606154 |
109 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.78677701 |
110 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78614601 |
111 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78341392 |
112 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.78232164 |
113 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.78001329 |
114 | NCOR_22424771_ChIP-Seq_293T_Human | 0.75744256 |
115 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.75173292 |
116 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.74890488 |
117 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.74714102 |
118 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.74310853 |
119 | FUS_26573619_Chip-Seq_HEK293_Human | 0.73686179 |
120 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.73561699 |
121 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.72405384 |
122 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.71911299 |
123 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.71864931 |
124 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.71672090 |
125 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.70598476 |
126 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.70059754 |
127 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.66111469 |
128 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.65877528 |
129 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.65833289 |
130 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.65456731 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003806_abnormal_nucleotide_metabolis | 3.88050716 |
2 | MP0001529_abnormal_vocalization | 3.66935009 |
3 | MP0003880_abnormal_central_pattern | 3.20842070 |
4 | MP0009379_abnormal_foot_pigmentation | 3.15856642 |
5 | MP0006036_abnormal_mitochondrial_physio | 3.01828797 |
6 | MP0001905_abnormal_dopamine_level | 2.95286541 |
7 | MP0002837_dystrophic_cardiac_calcinosis | 2.65630221 |
8 | MP0003646_muscle_fatigue | 2.58024702 |
9 | MP0003136_yellow_coat_color | 2.45238018 |
10 | MP0006035_abnormal_mitochondrial_morpho | 2.43528140 |
11 | MP0000749_muscle_degeneration | 2.38281779 |
12 | MP0003011_delayed_dark_adaptation | 2.20764139 |
13 | MP0006276_abnormal_autonomic_nervous | 2.19489612 |
14 | MP0004142_abnormal_muscle_tone | 2.17769513 |
15 | MP0002736_abnormal_nociception_after | 2.07092450 |
16 | MP0003718_maternal_effect | 1.96474875 |
17 | MP0003186_abnormal_redox_activity | 1.93274055 |
18 | MP0003950_abnormal_plasma_membrane | 1.92251568 |
19 | MP0004036_abnormal_muscle_relaxation | 1.91314042 |
20 | MP0008260_abnormal_autophagy | 1.88770398 |
21 | MP0005451_abnormal_body_composition | 1.87047222 |
22 | MP0002653_abnormal_ependyma_morphology | 1.74923438 |
23 | MP0008058_abnormal_DNA_repair | 1.74349868 |
24 | MP0002148_abnormal_hypersensitivity_rea | 1.73807043 |
25 | MP0005174_abnormal_tail_pigmentation | 1.72356820 |
26 | MP0004043_abnormal_pH_regulation | 1.70851768 |
27 | MP0000920_abnormal_myelination | 1.70612399 |
28 | MP0005671_abnormal_response_to | 1.68610691 |
29 | MP0001727_abnormal_embryo_implantation | 1.66476132 |
30 | MP0004145_abnormal_muscle_electrophysio | 1.66395942 |
31 | MP0003786_premature_aging | 1.66041319 |
32 | MP0001986_abnormal_taste_sensitivity | 1.63195495 |
33 | MP0008932_abnormal_embryonic_tissue | 1.62932965 |
34 | MP0005075_abnormal_melanosome_morpholog | 1.62027272 |
35 | MP0000372_irregular_coat_pigmentation | 1.58243812 |
36 | MP0000750_abnormal_muscle_regeneration | 1.57803428 |
37 | MP0001968_abnormal_touch/_nociception | 1.51839390 |
38 | MP0002876_abnormal_thyroid_physiology | 1.51534482 |
39 | MP0002277_abnormal_respiratory_mucosa | 1.48984971 |
40 | MP0006292_abnormal_olfactory_placode | 1.47707238 |
41 | MP0005084_abnormal_gallbladder_morpholo | 1.46157871 |
42 | MP0005171_absent_coat_pigmentation | 1.44659637 |
43 | MP0002638_abnormal_pupillary_reflex | 1.44650608 |
44 | MP0005408_hypopigmentation | 1.43330781 |
45 | MP0004147_increased_porphyrin_level | 1.43158374 |
46 | MP0003195_calcinosis | 1.42981313 |
47 | MP0002272_abnormal_nervous_system | 1.42892014 |
48 | MP0009785_altered_susceptibility_to | 1.42237523 |
49 | MP0000343_altered_response_to | 1.32245994 |
50 | MP0002095_abnormal_skin_pigmentation | 1.31326173 |
51 | MP0003315_abnormal_perineum_morphology | 1.30734966 |
52 | MP0004215_abnormal_myocardial_fiber | 1.28727576 |
53 | MP0000566_synostosis | 1.25592625 |
54 | MP0009333_abnormal_splenocyte_physiolog | 1.24096772 |
55 | MP0002734_abnormal_mechanical_nocicepti | 1.20465352 |
56 | MP0005409_darkened_coat_color | 1.20380646 |
57 | MP0000751_myopathy | 1.18840207 |
58 | MP0009697_abnormal_copulation | 1.18717112 |
59 | MP0008789_abnormal_olfactory_epithelium | 1.18478617 |
60 | MP0005330_cardiomyopathy | 1.17890778 |
61 | MP0001919_abnormal_reproductive_system | 1.17809923 |
62 | MP0005410_abnormal_fertilization | 1.15395255 |
63 | MP0006072_abnormal_retinal_apoptosis | 1.14492441 |
64 | MP0002160_abnormal_reproductive_system | 1.14415067 |
65 | MP0005389_reproductive_system_phenotype | 1.13573923 |
66 | MP0004381_abnormal_hair_follicle | 1.12719180 |
67 | MP0008875_abnormal_xenobiotic_pharmacok | 1.12552068 |
68 | MP0001485_abnormal_pinna_reflex | 1.11930317 |
69 | MP0000747_muscle_weakness | 1.10866430 |
70 | MP0005379_endocrine/exocrine_gland_phen | 1.10862317 |
71 | MP0001756_abnormal_urination | 1.09540036 |
72 | MP0010386_abnormal_urinary_bladder | 1.08647402 |
73 | MP0004957_abnormal_blastocyst_morpholog | 1.08034701 |
74 | MP0003693_abnormal_embryo_hatching | 1.07742003 |
75 | MP0005083_abnormal_biliary_tract | 1.07215150 |
76 | MP0004133_heterotaxia | 1.06062717 |
77 | MP0003137_abnormal_impulse_conducting | 1.06034876 |
78 | MP0005645_abnormal_hypothalamus_physiol | 1.02725559 |
79 | MP0004742_abnormal_vestibular_system | 1.02666151 |
80 | MP0002064_seizures | 1.02127939 |
81 | MP0002822_catalepsy | 1.01508768 |
82 | MP0009840_abnormal_foam_cell | 1.00871641 |
83 | MP0009764_decreased_sensitivity_to | 0.99992401 |
84 | MP0005332_abnormal_amino_acid | 0.99159513 |
85 | MP0000685_abnormal_immune_system | 0.99020962 |
86 | MP0004084_abnormal_cardiac_muscle | 0.98437373 |
87 | MP0005646_abnormal_pituitary_gland | 0.98425424 |
88 | MP0008995_early_reproductive_senescence | 0.98203007 |
89 | MP0005058_abnormal_lysosome_morphology | 0.97886289 |
90 | MP0000762_abnormal_tongue_morphology | 0.97366406 |
91 | MP0000026_abnormal_inner_ear | 0.97063861 |
92 | MP0005551_abnormal_eye_electrophysiolog | 0.96946104 |
93 | MP0001970_abnormal_pain_threshold | 0.96380975 |
94 | MP0001188_hyperpigmentation | 0.95658861 |
95 | MP0005423_abnormal_somatic_nervous | 0.95551690 |
96 | MP0009046_muscle_twitch | 0.95491947 |
97 | MP0003938_abnormal_ear_development | 0.94708843 |
98 | MP0002132_abnormal_respiratory_system | 0.93888912 |
99 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.93878981 |
100 | MP0001963_abnormal_hearing_physiology | 0.93554864 |
101 | MP0001440_abnormal_grooming_behavior | 0.93019454 |
102 | MP0005319_abnormal_enzyme/_coenzyme | 0.92919256 |
103 | MP0002139_abnormal_hepatobiliary_system | 0.91604779 |
104 | MP0005253_abnormal_eye_physiology | 0.91404000 |
105 | MP0002229_neurodegeneration | 0.91227309 |
106 | MP0001664_abnormal_digestion | 0.91164876 |
107 | MP0003122_maternal_imprinting | 0.90956377 |
108 | MP0008872_abnormal_physiological_respon | 0.90919417 |
109 | MP0002295_abnormal_pulmonary_circulatio | 0.89780354 |
110 | MP0004019_abnormal_vitamin_homeostasis | 0.89234194 |
111 | MP0008007_abnormal_cellular_replicative | 0.88670918 |
112 | MP0002751_abnormal_autonomic_nervous | 0.88588200 |
113 | MP0005636_abnormal_mineral_homeostasis | 0.87259544 |
114 | MP0002163_abnormal_gland_morphology | 0.86320853 |
115 | MP0004924_abnormal_behavior | 0.85812787 |
116 | MP0005386_behavior/neurological_phenoty | 0.85812787 |
117 | MP0001542_abnormal_bone_strength | 0.85565520 |
118 | MP0008469_abnormal_protein_level | 0.85302646 |
119 | MP0004270_analgesia | 0.83956448 |
120 | MP0004484_altered_response_of | 0.82896970 |
121 | MP0004782_abnormal_surfactant_physiolog | 0.82368482 |
122 | MP0010030_abnormal_orbit_morphology | 0.82295488 |
123 | MP0005670_abnormal_white_adipose | 0.81522221 |
124 | MP0001764_abnormal_homeostasis | 0.81375704 |
125 | MP0002938_white_spotting | 0.80609063 |
126 | MP0009643_abnormal_urine_homeostasis | 0.80584133 |
127 | MP0009745_abnormal_behavioral_response | 0.79953630 |
128 | MP0005025_abnormal_response_to | 0.79167510 |
129 | MP0002106_abnormal_muscle_physiology | 0.78390582 |
130 | MP0005266_abnormal_metabolism | 0.78302123 |
131 | MP0001790_abnormal_immune_system | 0.77665551 |
132 | MP0005387_immune_system_phenotype | 0.77665551 |
133 | MP0000230_abnormal_systemic_arterial | 0.77437275 |
134 | MP0002102_abnormal_ear_morphology | 0.76204258 |
135 | MP0002067_abnormal_sensory_capabilities | 0.75958839 |
136 | MP0000538_abnormal_urinary_bladder | 0.75663703 |
137 | MP0003123_paternal_imprinting | 0.74746284 |
138 | MP0002752_abnormal_somatic_nervous | 0.74240590 |
139 | MP0002693_abnormal_pancreas_physiology | 0.73887567 |
140 | MP0002733_abnormal_thermal_nociception | 0.73730832 |
141 | MP0000358_abnormal_cell_content/ | 0.73217709 |
142 | MP0001984_abnormal_olfaction | 0.72802287 |
143 | MP0005620_abnormal_muscle_contractility | 0.72448821 |
144 | MP0000778_abnormal_nervous_system | 0.72265349 |
145 | MP0002210_abnormal_sex_determination | 0.72120904 |
146 | MP0001835_abnormal_antigen_presentation | 0.71756596 |
147 | MP0002723_abnormal_immune_serum | 0.71642654 |
148 | MP0005000_abnormal_immune_tolerance | 0.70497336 |
149 | MP0001800_abnormal_humoral_immune | 0.70043343 |
150 | MP0001845_abnormal_inflammatory_respons | 0.69371204 |
151 | MP0001944_abnormal_pancreas_morphology | 0.69046175 |
152 | MP0003111_abnormal_nucleus_morphology | 0.64566671 |
153 | MP0002452_abnormal_antigen_presenting | 0.63738868 |
154 | MP0002234_abnormal_pharynx_morphology | 0.62111735 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.82697280 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.12100768 |
3 | Mitochondrial inheritance (HP:0001427) | 5.93105389 |
4 | Acute encephalopathy (HP:0006846) | 5.76682773 |
5 | Progressive macrocephaly (HP:0004481) | 5.53301684 |
6 | Hepatocellular necrosis (HP:0001404) | 5.22378258 |
7 | Increased CSF lactate (HP:0002490) | 5.14525771 |
8 | Hepatic necrosis (HP:0002605) | 4.80230655 |
9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.52029614 |
10 | Abnormality of glycolysis (HP:0004366) | 4.50260737 |
11 | Increased serum pyruvate (HP:0003542) | 4.50260737 |
12 | Cerebral edema (HP:0002181) | 4.32890867 |
13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.24822364 |
14 | Lipid accumulation in hepatocytes (HP:0006561) | 4.21697377 |
15 | Renal Fanconi syndrome (HP:0001994) | 4.20700891 |
16 | 3-Methylglutaconic aciduria (HP:0003535) | 4.05127476 |
17 | Respiratory failure (HP:0002878) | 3.78076137 |
18 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.72449945 |
19 | Leukodystrophy (HP:0002415) | 3.71628631 |
20 | Exercise intolerance (HP:0003546) | 3.68374753 |
21 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.66465270 |
22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.66465270 |
23 | Increased serum lactate (HP:0002151) | 3.63967370 |
24 | Lactic acidosis (HP:0003128) | 3.63507146 |
25 | Optic disc pallor (HP:0000543) | 3.49552406 |
26 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.46678742 |
27 | Increased intramyocellular lipid droplets (HP:0012240) | 3.44306178 |
28 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.16123115 |
29 | Increased muscle lipid content (HP:0009058) | 3.05950000 |
30 | Microvesicular hepatic steatosis (HP:0001414) | 3.01961021 |
31 | Exertional dyspnea (HP:0002875) | 2.83327826 |
32 | Cerebral hypomyelination (HP:0006808) | 2.79109388 |
33 | Abnormal number of erythroid precursors (HP:0012131) | 2.71465577 |
34 | Abnormality of renal resorption (HP:0011038) | 2.67919841 |
35 | Reduced antithrombin III activity (HP:0001976) | 2.65878033 |
36 | Lethargy (HP:0001254) | 2.57499765 |
37 | Abnormal protein glycosylation (HP:0012346) | 2.57432267 |
38 | Abnormal glycosylation (HP:0012345) | 2.57432267 |
39 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.57432267 |
40 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.57432267 |
41 | Neuroendocrine neoplasm (HP:0100634) | 2.55960448 |
42 | CNS demyelination (HP:0007305) | 2.53677366 |
43 | Sensory axonal neuropathy (HP:0003390) | 2.53155042 |
44 | Pheochromocytoma (HP:0002666) | 2.52440378 |
45 | Respiratory difficulties (HP:0002880) | 2.52429163 |
46 | Macrocytic anemia (HP:0001972) | 2.48673185 |
47 | Glycosuria (HP:0003076) | 2.47519225 |
48 | Abnormality of urine glucose concentration (HP:0011016) | 2.47519225 |
49 | Parakeratosis (HP:0001036) | 2.37982571 |
50 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.37552131 |
51 | Stenosis of the external auditory canal (HP:0000402) | 2.29526786 |
52 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.28718570 |
53 | Congenital, generalized hypertrichosis (HP:0004540) | 2.27890782 |
54 | X-linked dominant inheritance (HP:0001423) | 2.27047481 |
55 | Spastic paraparesis (HP:0002313) | 2.21870487 |
56 | Dicarboxylic aciduria (HP:0003215) | 2.21798647 |
57 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.21798647 |
58 | Emotional lability (HP:0000712) | 2.17197008 |
59 | Pancytopenia (HP:0001876) | 2.12225400 |
60 | Amniotic constriction ring (HP:0009775) | 2.11424611 |
61 | Abnormality of placental membranes (HP:0011409) | 2.11424611 |
62 | Hyperphosphaturia (HP:0003109) | 2.10524657 |
63 | Calf muscle hypertrophy (HP:0008981) | 2.08161835 |
64 | Rib fusion (HP:0000902) | 2.05530625 |
65 | Absent thumb (HP:0009777) | 2.04433583 |
66 | Type 2 muscle fiber atrophy (HP:0003554) | 2.03300188 |
67 | Muscle fiber atrophy (HP:0100295) | 2.01876810 |
68 | Abnormality of midbrain morphology (HP:0002418) | 2.00755038 |
69 | Molar tooth sign on MRI (HP:0002419) | 2.00755038 |
70 | Myokymia (HP:0002411) | 1.99397608 |
71 | Palpitations (HP:0001962) | 1.98792043 |
72 | Oral leukoplakia (HP:0002745) | 1.97722466 |
73 | Type I transferrin isoform profile (HP:0003642) | 1.95201066 |
74 | Methylmalonic aciduria (HP:0012120) | 1.93907669 |
75 | Rough bone trabeculation (HP:0100670) | 1.86375327 |
76 | CNS hypomyelination (HP:0003429) | 1.86318356 |
77 | Rimmed vacuoles (HP:0003805) | 1.84778970 |
78 | Ragged-red muscle fibers (HP:0003200) | 1.82809817 |
79 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.82671238 |
80 | Brushfield spots (HP:0001088) | 1.82658444 |
81 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.82622436 |
82 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.82622436 |
83 | Congenital malformation of the right heart (HP:0011723) | 1.81038153 |
84 | Double outlet right ventricle (HP:0001719) | 1.81038153 |
85 | Opisthotonus (HP:0002179) | 1.80926157 |
86 | Delusions (HP:0000746) | 1.79232471 |
87 | Reticulocytopenia (HP:0001896) | 1.78867271 |
88 | Abnormal urine phosphate concentration (HP:0012599) | 1.76429345 |
89 | Vomiting (HP:0002013) | 1.76360583 |
90 | Methylmalonic acidemia (HP:0002912) | 1.74524551 |
91 | Progressive external ophthalmoplegia (HP:0000590) | 1.74392048 |
92 | Progressive microcephaly (HP:0000253) | 1.73826737 |
93 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.72478321 |
94 | Congenital stationary night blindness (HP:0007642) | 1.72457147 |
95 | Pallor (HP:0000980) | 1.71806669 |
96 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.71692882 |
97 | Partial duplication of thumb phalanx (HP:0009944) | 1.70790515 |
98 | Ketosis (HP:0001946) | 1.70614778 |
99 | Microretrognathia (HP:0000308) | 1.68998201 |
100 | Split foot (HP:0001839) | 1.66954616 |
101 | Muscle fiber splitting (HP:0003555) | 1.66126515 |
102 | Nausea (HP:0002018) | 1.65976919 |
103 | Hypoplastic left heart (HP:0004383) | 1.65585385 |
104 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.65581100 |
105 | Cerebral hemorrhage (HP:0001342) | 1.65069649 |
106 | Pancreatic cysts (HP:0001737) | 1.64398086 |
107 | Abnormal hemoglobin (HP:0011902) | 1.63906529 |
108 | Medial flaring of the eyebrow (HP:0010747) | 1.63193156 |
109 | Progressive muscle weakness (HP:0003323) | 1.62407917 |
110 | Pancreatic fibrosis (HP:0100732) | 1.62254712 |
111 | Rhabdomyolysis (HP:0003201) | 1.61815928 |
112 | Testicular atrophy (HP:0000029) | 1.61041713 |
113 | Abnormal trabecular bone morphology (HP:0100671) | 1.59927537 |
114 | Abnormal pupillary function (HP:0007686) | 1.59299123 |
115 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.58724420 |
116 | Poor suck (HP:0002033) | 1.57208270 |
117 | Blindness (HP:0000618) | 1.55985441 |
118 | Hypoplastic heart (HP:0001961) | 1.55976810 |
119 | Prolonged neonatal jaundice (HP:0006579) | 1.54509567 |
120 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.54057975 |
121 | Gliosis (HP:0002171) | 1.53876711 |
122 | Cleft eyelid (HP:0000625) | 1.53356230 |
123 | Generalized aminoaciduria (HP:0002909) | 1.52787397 |
124 | Ileus (HP:0002595) | 1.52708217 |
125 | Nephronophthisis (HP:0000090) | 1.52643130 |
126 | Hyperglycinemia (HP:0002154) | 1.52538875 |
127 | Metabolic acidosis (HP:0001942) | 1.52145319 |
128 | Renal tubular dysfunction (HP:0000124) | 1.51922370 |
129 | Hypothermia (HP:0002045) | 1.51003450 |
130 | Nasolacrimal duct obstruction (HP:0000579) | 1.50821868 |
131 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.50233472 |
132 | Abnormality of alanine metabolism (HP:0010916) | 1.50233472 |
133 | Hyperalaninemia (HP:0003348) | 1.50233472 |
134 | Aplastic anemia (HP:0001915) | 1.49407400 |
135 | Partial duplication of the phalanx of hand (HP:0009999) | 1.48683580 |
136 | Congenital primary aphakia (HP:0007707) | 1.47839868 |
137 | Paralysis (HP:0003470) | 1.46061881 |
138 | Premature graying of hair (HP:0002216) | 1.45872614 |
139 | True hermaphroditism (HP:0010459) | 1.45557361 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.19912448 |
2 | BUB1 | 4.10022689 |
3 | NME2 | 3.81328482 |
4 | ARAF | 3.32058964 |
5 | STK39 | 3.16508605 |
6 | PBK | 2.95091209 |
7 | STK16 | 2.89733494 |
8 | NME1 | 2.88753924 |
9 | BRAF | 2.35961031 |
10 | EIF2AK1 | 2.13831731 |
11 | OXSR1 | 2.08171221 |
12 | WNK4 | 2.03215370 |
13 | LIMK1 | 1.99714746 |
14 | MAP4K2 | 1.97333797 |
15 | BCKDK | 1.96370668 |
16 | OBSCN | 1.95661781 |
17 | MYLK | 1.86233633 |
18 | MST4 | 1.84002579 |
19 | VRK1 | 1.83871749 |
20 | PIM2 | 1.82728698 |
21 | CASK | 1.77200334 |
22 | TESK2 | 1.77198775 |
23 | MAPK15 | 1.70169970 |
24 | BCR | 1.67877094 |
25 | TLK1 | 1.53554980 |
26 | MAP3K12 | 1.48349289 |
27 | EIF2AK3 | 1.48210229 |
28 | TXK | 1.46505823 |
29 | TNIK | 1.38047257 |
30 | ABL2 | 1.36576205 |
31 | DYRK2 | 1.29887155 |
32 | CDK19 | 1.29789379 |
33 | MAPKAPK5 | 1.29436043 |
34 | GRK1 | 1.24206677 |
35 | CSNK1G3 | 1.23364510 |
36 | MAP2K2 | 1.20033604 |
37 | SRPK1 | 1.17527252 |
38 | IKBKB | 1.17073041 |
39 | PLK4 | 1.16883626 |
40 | NUAK1 | 1.11635592 |
41 | GRK5 | 1.10706389 |
42 | CAMK2D | 1.10620447 |
43 | LRRK2 | 1.09270533 |
44 | TRIM28 | 1.08400036 |
45 | WEE1 | 1.06694675 |
46 | CAMK2B | 1.06687693 |
47 | MUSK | 1.05038679 |
48 | PKN1 | 0.99089489 |
49 | GRK7 | 0.97629794 |
50 | IRAK1 | 0.96962687 |
51 | PINK1 | 0.96540996 |
52 | TESK1 | 0.95710971 |
53 | AURKA | 0.93548910 |
54 | PIK3CA | 0.90170337 |
55 | CAMK2G | 0.89580850 |
56 | DAPK1 | 0.85684418 |
57 | MAP3K11 | 0.85667171 |
58 | EPHB2 | 0.85319588 |
59 | ADRBK2 | 0.84122325 |
60 | CSNK1G1 | 0.82730595 |
61 | MAP2K7 | 0.82645611 |
62 | DAPK3 | 0.82565472 |
63 | RPS6KA5 | 0.81996877 |
64 | CDK8 | 0.80400498 |
65 | MAPKAPK3 | 0.79902625 |
66 | CDC7 | 0.79856191 |
67 | IRAK2 | 0.72218540 |
68 | TAOK2 | 0.72137578 |
69 | BMPR1B | 0.71933005 |
70 | BMPR2 | 0.71619970 |
71 | PAK1 | 0.70350950 |
72 | ZAK | 0.68125309 |
73 | ILK | 0.67688843 |
74 | CDK14 | 0.66634029 |
75 | NEK1 | 0.66599451 |
76 | CSNK1A1L | 0.65623693 |
77 | AURKB | 0.65599483 |
78 | NEK6 | 0.65039338 |
79 | DYRK3 | 0.64995734 |
80 | UHMK1 | 0.64472762 |
81 | CAMK2A | 0.64087114 |
82 | ROCK2 | 0.63759383 |
83 | MET | 0.61351906 |
84 | MST1R | 0.61321809 |
85 | TAF1 | 0.60940541 |
86 | BRSK2 | 0.59661566 |
87 | TBK1 | 0.59259411 |
88 | PRKCI | 0.58513652 |
89 | PDK2 | 0.58062368 |
90 | MAP4K1 | 0.57982479 |
91 | IRAK3 | 0.56646706 |
92 | PNCK | 0.56035350 |
93 | CSNK1G2 | 0.54500747 |
94 | PRKCE | 0.53842964 |
95 | PLK2 | 0.53604454 |
96 | CCNB1 | 0.53557189 |
97 | INSRR | 0.52868847 |
98 | PDK3 | 0.51822863 |
99 | PDK4 | 0.51822863 |
100 | MAP2K6 | 0.51581693 |
101 | TIE1 | 0.49792030 |
102 | MOS | 0.49061082 |
103 | PASK | 0.48394929 |
104 | CSNK2A1 | 0.48253417 |
105 | PRKCG | 0.48048485 |
106 | PRKCD | 0.47864117 |
107 | STK38L | 0.45390628 |
108 | PLK3 | 0.45238527 |
109 | CDK18 | 0.44901200 |
110 | ADRBK1 | 0.44405135 |
111 | PRKACA | 0.44383522 |
112 | WNK3 | 0.44012251 |
113 | CAMKK2 | 0.42881495 |
114 | MKNK1 | 0.42150814 |
115 | MAPK13 | 0.41934950 |
116 | CDK15 | 0.41566999 |
117 | STK4 | 0.40647043 |
118 | CSNK2A2 | 0.40369613 |
119 | RPS6KB2 | 0.40270871 |
120 | CDK11A | 0.39586151 |
121 | CHEK2 | 0.39156702 |
122 | IRAK4 | 0.39074234 |
123 | LYN | 0.38611236 |
124 | PAK4 | 0.37990925 |
125 | GRK6 | 0.37952425 |
126 | TSSK6 | 0.37549151 |
127 | ERBB4 | 0.35726711 |
128 | IKBKE | 0.34823240 |
129 | ITK | 0.34326293 |
130 | STK24 | 0.34119186 |
131 | PHKG2 | 0.33842100 |
132 | PHKG1 | 0.33842100 |
133 | PLK1 | 0.33802617 |
134 | CSNK1A1 | 0.32459091 |
135 | ATR | 0.32421104 |
136 | PRKCQ | 0.32375586 |
137 | AKT3 | 0.32286005 |
138 | KDR | 0.32049804 |
139 | BRSK1 | 0.31733542 |
140 | AKT2 | 0.31438634 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.76716026 |
2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.87926240 |
3 | Ribosome_Homo sapiens_hsa03010 | 3.89915349 |
4 | Proteasome_Homo sapiens_hsa03050 | 3.73690840 |
5 | Alzheimers disease_Homo sapiens_hsa05010 | 3.58112377 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.48203436 |
7 | Protein export_Homo sapiens_hsa03060 | 3.06231960 |
8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.99172383 |
9 | RNA polymerase_Homo sapiens_hsa03020 | 2.83799848 |
10 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.68856030 |
11 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.29714240 |
12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.07097775 |
13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.03086296 |
14 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.99195301 |
15 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.96416779 |
16 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.70555461 |
17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.57168859 |
18 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.42382519 |
19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.39309638 |
20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.32128365 |
21 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.18693030 |
22 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16532868 |
23 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.14441541 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.11434312 |
25 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.09165658 |
26 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.06991077 |
27 | Asthma_Homo sapiens_hsa05310 | 1.06327245 |
28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.04584475 |
29 | Metabolic pathways_Homo sapiens_hsa01100 | 1.03693412 |
30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.03242003 |
31 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.02321254 |
32 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.01876530 |
33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.00046815 |
34 | Purine metabolism_Homo sapiens_hsa00230 | 1.00038196 |
35 | Homologous recombination_Homo sapiens_hsa03440 | 0.99900420 |
36 | Sulfur relay system_Homo sapiens_hsa04122 | 0.95764776 |
37 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.94690131 |
38 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.94562567 |
39 | Basal transcription factors_Homo sapiens_hsa03022 | 0.94180573 |
40 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91406476 |
41 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.90963998 |
42 | Peroxisome_Homo sapiens_hsa04146 | 0.90882809 |
43 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.90660210 |
44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.89859526 |
45 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.89602165 |
46 | Allograft rejection_Homo sapiens_hsa05330 | 0.84314566 |
47 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.83630978 |
48 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.83617443 |
49 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.82589318 |
50 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.79926190 |
51 | Spliceosome_Homo sapiens_hsa03040 | 0.78026644 |
52 | Carbon metabolism_Homo sapiens_hsa01200 | 0.77757899 |
53 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.76715429 |
54 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.76659932 |
55 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75857541 |
56 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.75854575 |
57 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.75377162 |
58 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.74491057 |
59 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.72789433 |
60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.71400741 |
61 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.68248271 |
62 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.67875901 |
63 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.67646121 |
64 | DNA replication_Homo sapiens_hsa03030 | 0.67199740 |
65 | Histidine metabolism_Homo sapiens_hsa00340 | 0.66589367 |
66 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.65338971 |
67 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.65275777 |
68 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.64753111 |
69 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.63686290 |
70 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.62475668 |
71 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.61618046 |
72 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.61057069 |
73 | Mismatch repair_Homo sapiens_hsa03430 | 0.59391406 |
74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58116206 |
75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.56521965 |
76 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.55697889 |
77 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53344822 |
78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51821244 |
79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.44998305 |
80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.44724851 |
81 | RNA degradation_Homo sapiens_hsa03018 | 0.44668916 |
82 | RNA transport_Homo sapiens_hsa03013 | 0.44149621 |
83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43906605 |
84 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.43760500 |
85 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42151269 |
86 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39820547 |
87 | Galactose metabolism_Homo sapiens_hsa00052 | 0.38754478 |
88 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.38392508 |
89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.38267927 |
90 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.35311375 |
91 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.33121162 |
92 | Base excision repair_Homo sapiens_hsa03410 | 0.32227492 |
93 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.31998967 |
94 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.31703731 |
95 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30315096 |
96 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29702408 |
97 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.28264851 |
98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.28190191 |
99 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.26792629 |
100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26211354 |
101 | Phagosome_Homo sapiens_hsa04145 | 0.25524240 |
102 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.24475286 |
103 | Alcoholism_Homo sapiens_hsa05034 | 0.21810671 |
104 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.21643005 |
105 | Lysosome_Homo sapiens_hsa04142 | 0.21393436 |
106 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.21050491 |
107 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.21021276 |
108 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.20382682 |
109 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.20109970 |
110 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.18717117 |
111 | Nicotine addiction_Homo sapiens_hsa05033 | 0.16427856 |
112 | Phototransduction_Homo sapiens_hsa04744 | 0.13842458 |
113 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.11662814 |
114 | Taste transduction_Homo sapiens_hsa04742 | 0.11027091 |
115 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.10640921 |
116 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.10544360 |
117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.09633102 |
118 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.08962027 |
119 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.08490156 |
120 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.07872027 |
121 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.07604185 |
122 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.05717218 |